ssp5005
- Apparent physicochemical properties on 2-D gel
- Molecular mass = 23.8 kDa
- Isoelectric point = 5.8
- Identification
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)
- Method: peptide mass fingerprint (PMF)
- Theoretical Mw and pI
- Tissue/cell specificity
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients..
- Subcellular location
Cytoplasm.
- Activities/functions
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
- Related databases
UniProtKB/Swiss-Prot: P09936 (UCHL1_HUMAN)