ssp7001
- Apparent physicochemical properties on 2-D gel
- Molecular mass = 17.31 kDa
- Isoelectric point = 6.02
- Identification
Protein name = Stathmin (Oncoprotein 18)
- Method: peptide mass fingerprint (PMF) and peptide sequencing
- Theoretical properties
- Molecular mass (Isoform 1) = 17,303 Da
- Isoelectric point (Isoform 1) = 5.75
- Tissue/cell specificity
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver.
- Intracellular localization
Cytoskeleton
- Activities/functions
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.
- Related databases
UniProtKB/Swiss-Prot: P16949 (STMN1_HUMAN)