ssp3006
- Apparent physicochemical properties on 2-D gel
- Molecular mass = 16.3 kDa
- Isoelectric point = 5.5
- Identification
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1)(Eukaryotic initiation factor 5A isoform 1)
- Method: peptide mass fingerprint (PMF)
- Theoretical Mw and pI
- Tissue/cell specificity
Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
- Subcellular location
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
- Activities/functions
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.
- Related databases
UniProtKB/Swiss-Prot: P63241 (IF5A1_HUMAN)