Chr	Start	End	Ref	Alt	Func.refGene	Gene.refGene	GeneDetail.refGene	ExonicFunc.refGene	AAChange.refGene	phastConsElements46way	genomicSuperDups	esp6500si_all	1000g2012apr_all	cosmic65	nci60	snp137	avsift	LJB_PhyloP	LJB_PhyloP_Pred	LJB_SIFT	LJB_SIFT_Pred	LJB_PolyPhen2	LJB_PolyPhen2_Pred	LJB_LRT	LJB_LRT_Pred	LJB_MutationTaster	LJB_MutationTaster_Pred	LJB_GERP++	tumor_ref	tumor_var	misRate_tumor	normal_ref	normal_var	misRate_normal	p-value(Fisher)	strandRatio_tumor	strandRatio_normal	tumor_realign(total,ref,alt,freq)	normal_realign(total,ref,alt,freq)	p-value(Realaign)	p-value(EBcall)
chr1	17945924	17945924	G	T	exonic	ARHGEF10L		nonsynonymous SNV	ARHGEF10L:NM_001011722:exon8:c.G809T:p.G270V,ARHGEF10L:NM_018125:exon10:c.G926T:p.G309V	Score=480;Name=lod=119							0	0.998657	C	1.0	D	0.996	D	1.0	D	0.999114	D	4.29	50	20	0.286	115	0	0.000	5.18180018694935545e-10	0.600	---	60,44,16,0.267	97,97,0,0.000	7.295	6.587
chr1	19175932	19175932	C	T	exonic	TAS1R2		nonsynonymous SNV	TAS1R2:NM_152232:exon4:c.G1370A:p.R457Q			0.001076		ID=COSM1228511;OCCURENCE=1(large_intestine)		rs147544201	0.38	3.84E-4	N	0.52	T	0.0010	B	1.98E-4	N	6.5E-5	N	-9.34	124	71	0.364	239	3	0.012	4.53052770666254542e-25	0.394	0.333	165,106,59,0.358	189,187,2,0.011	19.608	60
chr1	29639085	29639085	G	A	exonic	PTPRU		nonsynonymous SNV	PTPRU:NM_001195001:exon22:c.G3085A:p.E1029K,PTPRU:NM_133178:exon22:c.G3094A:p.E1032K,PTPRU:NM_005704:exon23:c.G3124A:p.E1042K,PTPRU:NM_133177:exon23:c.G3112A:p.E1038K	Score=566;Name=lod=266		0.000077					0	0.999456	C	1.0	D	0.972	D	1.0	D	0.997469	D	3.88	103	20	0.163	152	0	0.000	4.06855925303147649e-08	0.700	---	106,91,15,0.142	125,125,0,0.000	5.324	7.475
chr1	89521759	89521759	A	G	exonic	GBP1		synonymous SNV	GBP1:NM_002053:exon8:c.T1308C:p.F436F		Score=0.925615;Name=chr1:89864783																		89	24	0.212	151	0	0.000	3.02336135980681117e-10	0.583	---	94,77,17,0.181	122,122,0,0.000	6.531	15.477
chr1	114483215	114483215	C	T	exonic	HIPK1		synonymous SNV	HIPK1:NM_152696:exon2:c.C210T:p.Y70Y,HIPK1:NM_198268:exon2:c.C210T:p.Y70Y	Score=515;Name=lod=165		0.000154																	162	23	0.124	252	0	0.000	1.12241975628205513e-09	0.478	---	161,141,20,0.124	208,208,0,0.000	7.511	11.894
chr1	156235884	156235884	C	T	exonic	SMG5		nonsynonymous SNV	SMG5:NM_015327:exon12:c.G1543A:p.E515K	Score=571;Name=lod=279							0.07	0.998767	C	0.77	T	0.06	B	0.999944	D	0.59991	D	5.16	135	67	0.332	298	0	0.000	1.80453314171854692e-30	0.522	---	179,118,61,0.341	248,248,0,0.000	26.123	60
chr1	160011508	160011508	C	T	exonic	KCNJ10		nonsynonymous SNV	KCNJ10:NM_002241:exon2:c.G815A:p.S272N	Score=651;Name=lod=591							1	0.984441	C	0.25	T	0.122	B	0.999927	D	0.539761	D	3.66	92	44	0.324	139	0	0.000	5.21916414148040513e-16	0.500	---	123,83,40,0.325	120,119,1,0.008	11.950	60
chr1	160269000	160269000	C	T	exonic	COPA		synonymous SNV	COPA:NM_001098398:exon18:c.G1749A:p.K583K,COPA:NM_004371:exon18:c.G1722A:p.K574K	Score=658;Name=lod=627																			79	31	0.282	159	0	0.000	5.10259582958883025e-14	0.355	---	99,71,28,0.283	127,127,0,0.000	11.117	60
chr1	161163522	161163522	G	A	exonic	ADAMTS4		nonsynonymous SNV	ADAMTS4:NM_005099:exon6:c.C1643T:p.T548M	Score=573;Name=lod=285							0.01	0.990922	C	1.0	D	0.95	D	0.996041	N	0.549391	D	3.6	97	84	0.464	155	0	0.000	2.03251530195597344e-28	0.524	---	154,82,72,0.468	125,124,0,0.000	22.549	60
chr1	182026052	182026052	G	A	exonic	ZNF648		nonsynonymous SNV	ZNF648:NM_001009992:exon2:c.C1094T:p.P365L	Score=578;Name=lod=297				ID=COSM208797;OCCURENCE=1(large_intestine)			0.03	0.94166	N	0.95	T	0.995	D	0.928209	NA	0.429546	N	0.894	201	107	0.347	359	0	0.000	7.5723954102234409e-42	0.486	---	277,181,93,0.339	300,300,0,0.000	34.148	60
chr1	197390856	197390856	T	C	exonic	CRB1		nonsynonymous SNV	CRB1:NM_001193640:exon4:c.T1562C:p.M521T,CRB1:NM_001257966:exon6:c.T1898C:p.M633T,CRB1:NM_201253:exon6:c.T1898C:p.M633T,CRB1:NM_001257965:exon8:c.T1691C:p.M564T								0.18	0.093104	N	0.95	T	0.01	B	0.58387	NA	2.0E-6	N	-2.35	87	47	0.351	171	0	0.000	6.88065143091927321e-20	0.447	---	120,76,44,0.367	143,143,0,0.000	17.272	60
chr1	200860730	200860730	G	A	exonic	C1orf106		nonsynonymous SNV	C1orf106:NM_018265:exon1:c.G104A:p.R35Q				0.0005			rs200890960	0.36	0.876982	N	1.0	D	0.34	P	0.013447	N	0.038423	N	-1.32	103	59	0.364	152	0	0.000	3.90206812658799973e-20	0.593	---	132,79,52,0.397	118,118,0,0.000	17.096	60
chr1	213403839	213403839	G	A	splicing	RPS6KC1	NM_001136138:exon8:c.1009-1G>A,NM_012424:exon9:c.1045-1G>A			Score=590;Name=lod=332																			40	22	0.355	60	0	0.000	5.14870810851743664e-08	0.636	---	47,28,18,0.391	46,46,0,0.000	6.018	13.366
chr1	228462398	228462398	C	A	exonic	OBSCN		nonsynonymous SNV	OBSCN:NM_001098623:exon20:c.C5809A:p.L1937M,OBSCN:NM_052843:exon20:c.C5809A:p.L1937M,OBSCN:NM_001271223:exon24:c.C6934A:p.L2312M								0.07												110	29	0.209	187	1	0.005	5.02611550632000156e-11	0.483	0.000	128,102,26,0.203	162,161,1,0.006	8.688	12.401
chr2	5833500	5833500	C	T	exonic	SOX11		nonsynonymous SNV	SOX11:NM_003108:exon1:c.C647T:p.T216M	Score=519;Name=lod=171							0.01	0.99297	C	1.0	D	0.526816	NA	0.810257	U	0.004553	N	3.04	113	48	0.298	243	0	0.000	4.8815116131805434e-22	0.833	---	135,94,41,0.304	209,208,0,0.000	18.472	60
chr2	28081427	28081427	C	T	exonic	RBKS		nonsynonymous SNV	RBKS:NM_022128:exon2:c.G101A:p.R34H	Score=534;Name=lod=197		0.000077					0	0.999129	C	1.0	D	0.997	D	0.99994	D	0.998859	D	5.49	59	27	0.314	104	0	0.000	3.61720108032794309e-11	0.333	---	76,52,24,0.316	88,88,0,0.000	9.019	9.446
chr2	68882135	68882135	G	A	exonic	PROKR1		synonymous SNV	PROKR1:NM_138964:exon2:c.G609A:p.E203E	Score=289;Name=lod=20																			122	54	0.307	263	0	0.000	1.21837712557164555e-24	0.556	---	146,97,48,0.331	220,220,0,0.000	21.663	60
chr2	84832698	84832698	C	T	exonic	DNAH6		synonymous SNV	DNAH6:NM_001370:exon20:c.C3156T:p.G1052G					ID=COSM1409723;OCCURENCE=1(large_intestine)															45	23	0.338	106	0	0.000	2.7836491654126192e-11	0.435	---	56,38,18,0.321	80,80,0,0.000	7.759	15.955
chr2	141072660	141072660	A	G	exonic	LRP1B		nonsynonymous SNV	LRP1B:NM_018557:exon83:c.T12649C:p.C4217R	Score=631;Name=lod=489							0.01	0.999193	C	1.0	D	0.999	D	0.999956	D	0.937288	D	5.71	48	15	0.238	78	0	0.000	1.99593060166100514e-06	0.267	---	53,41,12,0.226	65,65,0,0.000	4.505	13.051
chr2	179639069	179639069	A	T	exonic	TTN		nonsynonymous SNV	TTN:NM_003319:exon29:c.T6784A:p.S2262T,TTN:NM_133432:exon29:c.T6784A:p.S2262T,TTN:NM_133437:exon29:c.T6784A:p.S2262T,TTN:NM_001256850:exon30:c.T6922A:p.S2308T,TTN:NM_001267550:exon30:c.T6922A:p.S2308T,TTN:NM_133378:exon30:c.T6922A:p.S2308T,TTN:NM_133379:exon30:c.T6922A:p.S2308T	Score=666;Name=lod=676							0.27	0.998574	C	0.46	T	0.384487	NA	0.953686	NA	0.58246	D	5.17	125	20	0.138	197	0	0.000	1.571743338127109e-08	0.300	---	117,99,18,0.154	160,160,0,0.000	7.091	15.176
chr2	197008343	197008343	G	A	exonic	STK17B		nonsynonymous SNV	STK17B:NM_004226:exon5:c.C548T:p.S183F	Score=552;Name=lod=234							0	0.999718	C	1.0	D	1.0	D	0.999934	D	0.924469	D	4.94	85	14	0.141	147	0	0.000	1.62474409575902335e-06	0.571	---	85,73,12,0.141	121,121,0,0.000	4.825	7.558
chr2	217234732	217234732	G	A	exonic	MARCH4		synonymous SNV	MARCH4:NM_020814:exon1:c.C252T:p.A84A	Score=692;Name=lod=864																			139	22	0.137	198	0	0.000	9.34162924646986581e-09	0.591	---	147,128,19,0.129	165,165,0,0.000	6.495	5.603
chr2	220500191	220500191	C	T	exonic	SLC4A3		nonsynonymous SNV	SLC4A3:NM_005070:exon13:c.C1945T:p.R649W,SLC4A3:NM_201574:exon13:c.C2026T:p.R676W	Score=300;Name=lod=22							0.03	0.009549	N	0.81	T	0.25	P	0.266695	N	0.009041	N	4.57	66	34	0.340	127	0	0.000	1.81813747294528549e-14	0.235	---	93,62,31,0.333	111,111,0,0.000	11.990	60
chr2	240098157	240098157	G	A	exonic	HDAC4		nonsynonymous SNV	HDAC4:NM_006037:exon5:c.C442T:p.R148W	Score=577;Name=lod=294		0.000077				rs140596122	0	0.997327	C	0.98	D	0.999	D	0.999999	D	0.999124	D	2.69	106	20	0.159	126	0	0.000	8.41603297679824744e-07	0.300	---	107,89,18,0.168	105,105,0,0.000	5.453	8.638
chr3	33114105	33114105	C	T	exonic	GLB1		nonsynonymous SNV	GLB1:NM_000404:exon2:c.G176A:p.R59H,GLB1:NM_001079811:exon2:c.G86A:p.R29H,GLB1:NM_001135602:exon2:c.G176A:p.R59H	Score=393;Name=lod=53		0.000161				rs72555392	0	0.998938	C	1.0	D	1.0	D	1.0	D	0.999849	D	5.3	180	146	0.448	302	0	0.000	3.52696864238684089e-51	0.432	---	272,150,121,0.446	239,238,0,0.000	40.211	60
chr3	38519422	38519422	G	T	exonic	ACVR2B		stopgain	ACVR2B:NM_001106:exon3:c.G331T:p.E111X	Score=609;Name=lod=399							0.3	0.998873	C	0.903778	NA	0.735374	NA	0.999998	D	1.0	A	3.08	116	16	0.121	135	0	0.000	7.81338996943358219e-06	0.438	---	108,94,14,0.130	111,110,1,0.009	3.528	9.052
chr3	39178998	39178998	C	A	exonic	TTC21A		nonsynonymous SNV	TTC21A:NM_001105513:exon25:c.C3349A:p.L1117M,TTC21A:NM_145755:exon26:c.C3493A:p.L1165M	Score=602;Name=lod=372							0.01	0.801861	N	0.98	D	0.85	P	0.991992	N	0.724228	D	-0.667	214	24	0.101	202	0	0.000	3.400155792419708e-07	0.417	---	219,196,23,0.105	184,184,0,0.000	6.169	10.025
chr3	46875381	46875381	C	A	exonic	PRSS42		nonsynonymous SNV	PRSS42:NM_182702:exon1:c.G205T:p.D69Y	Score=265;Name=lod=16							0.08												99	79	0.444	192	0	0.000	6.92150251810208322e-31	0.671	---	160,89,71,0.444	157,157,0,0.000	25.362	60
chr3	50312799	50312799	G	A	exonic	SEMA3B		unknown	UNKNOWN	Score=609;Name=lod=397							0												230	100	0.303	284	0	0.000	4.26902654084765162e-31	0.660	---	277,197,80,0.289	240,239,0,0.000	24.198	60
chr3	52853477	52853477	A	T	exonic	ITIH4		nonsynonymous SNV	ITIH4:NM_001166449:exon15:c.T1919A:p.L640H,ITIH4:NM_002218:exon17:c.T2009A:p.L670H								0.48	0.02754	N	0.93	T	0.0050	B	8.0E-6	N	0.025381	N	-2.99	152	26	0.146	155	0	0.000	5.88181825379550438e-08	0.308	---	144,123,21,0.146	124,123,0,0.000	5.682	12.122
chr3	62355790	62355790	C	T	exonic	FEZF2		nonsynonymous SNV	FEZF2:NM_018008:exon5:c.G1348A:p.A450T	Score=510;Name=lod=157							0.83	0.928391	N	1.0	D	0.539587	NA	0.925195	N	0.001167	N	1.11	164	46	0.219	238	0	0.000	3.87352649625757716e-17	0.522	---	168,129,39,0.232	193,193,0,0.000	14.112	60
chr3	113085055	113085055	C	T	exonic	WDR52		stopgain	WDR52:NM_001164496:exon19:c.G2546A:p.W849X,WDR52:NM_018338:exon19:c.G2546A:p.W849X	Score=369;Name=lod=42								0.998974	C	0.903551	NA	0.737964	NA	1.0	NA	1.0	A	5.34	120	80	0.400	220	0	0.000	5.09704257040002144e-31	0.463	---	170,99,70,0.414	178,176,0,0.000	25.719	60
chr3	123010123	123010123	C	T	exonic	ADCY5		nonsynonymous SNV	ADCY5:NM_001199642:exon18:c.G2114A:p.R705H,ADCY5:NM_183357:exon18:c.G3164A:p.R1055H	Score=605;Name=lod=383				ID=COSM73589;OCCURENCE=1(ovary)				0.998014	C	0.95	T	0.713	P	0.999972	D	0.991614	D	4.18	214	65	0.233	248	0	0.000	3.60422087154604276e-20	0.369	---	249,190,59,0.237	204,204,0,0.000	16.789	60
chr3	129292561	129292561	C	T	exonic	PLXND1		nonsynonymous SNV	PLXND1:NM_015103:exon13:c.G2713A:p.G905S	Score=284;Name=lod=19							0	0.997736	C	1.0	D	0.997	D	0.999919	D	0.999996	D	4.59	77	68	0.469	153	1	0.006	4.51205436590746245e-25	0.441	0.000	116,65,51,0.440	125,124,1,0.008	17.853	60
chr3	193156375	193156375	T	C	splicing	ATP13A4	NM_032279:exon24:c.2563-2A>G			Score=552;Name=lod=234																			87	21	0.194	91	0	0.000	1.58166009566637774e-06	0.429	---	86,70,16,0.186	69,69,0,0.000	4.208	12.843
chr4	2453061	2453061	T	C	exonic	LOC402160		nonsynonymous SNV	LOC402160:NM_001193282:exon10:c.T938C:p.V313A	Score=495;Name=lod=137																			59	30	0.337	135	0	0.000	2.82673748938524184e-14	0.567	---	79,53,26,0.329	106,106,0,0.000	10.825	11.707
chr4	2951929	2951929	C	A	exonic	NOP14		nonsynonymous SNV	NOP14:NM_003703:exon8:c.G1014T:p.M338I	Score=309;Name=lod=24							0.38	0.998541	C	0.63	T	0.435	P	0.999889	D	0.081459	N	3.86	91	13	0.125	103	0	0.000	0.00016377576009195507	0.308	---	91,78,13,0.143	92,91,1,0.011	3.212	8.62
chr4	41621300	41621300	C	A	exonic	LIMCH1		nonsynonymous SNV	LIMCH1:NM_001112719:exon3:c.C316A:p.P106T,LIMCH1:NM_001112720:exon3:c.C316A:p.P106T,LIMCH1:NM_001112717:exon8:c.C778A:p.P260T,LIMCH1:NM_001112718:exon8:c.C778A:p.P260T,LIMCH1:NM_014988:exon8:c.C778A:p.P260T	Score=464;Name=lod=103							0.01	0.99918	C	0.99	D	0.869	D	0.998181	N	0.124593	N	5.54	136	74	0.352	214	0	0.000	9.50754182352562365e-27	0.527	---	176,114,62,0.352	181,181,0,0.000	21.929	60
chr4	48564908	48564908	G	C	exonic	FRYL		nonsynonymous SNV	FRYL:NM_015030:exon32:c.C3694G:p.Q1232E	Score=437;Name=lod=80							0.02	0.999796	C	0.897466	NA	0.720248	NA	1.0	D	0.948456	D	5.71	32	7	0.179	69	0	0.000	0.000551619863508145399	0.714	---	34,28,6,0.176	54,54,0,0.000	2.605	4.924
chr4	114279596	114279596	C	T	exonic	ANK2		synonymous SNV	ANK2:NM_001148:exon38:c.C9822T:p.P3274P			0.000077				rs144939151													118	64	0.352	199	0	0.000	2.5607035369857471e-24	0.453	---	166,107,58,0.352	173,173,0,0.000	20.776	60
chr4	120986857	120986857	A	G	exonic	MAD2L1		nonsynonymous SNV	MAD2L1:NM_002358:exon2:c.T190C:p.Y64H	Score=654;Name=lod=609							0	0.997777	C	1.0	D	0.999	D	1.0	D	0.999986	D	4.73	61	29	0.322	93	0	0.000	7.46766326017806904e-11	0.759	---	82,57,25,0.305	78,78,0,0.000	8.086	12.971
chr4	153245453	153245453	G	T	exonic	FBXW7		nonsynonymous SNV	FBXW7:NM_001013415:exon10:c.C1384A:p.H462N,FBXW7:NM_018315:exon10:c.C1498A:p.H500N,FBXW7:NM_033632:exon11:c.C1738A:p.H580N	Score=760;Name=lod=1635							0.07	0.999673	C	0.92	T	1.0	D	1.0	D	0.999958	D	5.35	46	20	0.303	126	0	0.000	5.94821446762546938e-11	0.300	---	55,37,18,0.327	97,97,0,0.000	8.853	60
chr4	153332769	153332769	C	A	exonic	FBXW7		stopgain	FBXW7:NM_033632:exon2:c.G187T:p.E63X,FBXW7:NM_001257069:exon4:c.G187T:p.E63X	Score=485;Name=lod=125							0.22	0.983405	C	0.917396	NA	0.570526	NA	0.078964	N	1.0	A	4.26	121	58	0.324	231	0	0.000	2.73608691925634167e-24	0.517	---	154,100,54,0.351	188,188,0,0.000	21.397	60
chr5	31526809	31526809	G	A	exonic	DROSHA		synonymous SNV	DROSHA:NM_013235:exon4:c.C231T:p.D77D,DROSHA:NM_001100412:exon5:c.C231T:p.D77D	Score=489;Name=lod=130																			161	20	0.110	153	0	0.000	5.12906573710779176e-06	0.950	---	166,141,24,0.145	127,127,0,0.000	6.043	5.397
chr5	80390773	80390773	C	T	exonic	RASGRF2		nonsynonymous SNV	RASGRF2:NM_006909:exon12:c.C1717T:p.R573C	Score=519;Name=lod=172							0.02	0.999103	C	0.99	D	0.998	D	1.0	D	0.801385	D	5.47	163	52	0.242	153	0	0.000	4.18394763489466692e-14	0.500	---	177,133,44,0.249	116,116,0,0.000	10.588	60
chr5	112173917	112173917	C	T	exonic	APC		stopgain	APC:NM_001127511:exon14:c.C2572T:p.R858X,APC:NM_000038:exon16:c.C2626T:p.R876X,APC:NM_001127510:exon17:c.C2626T:p.R876X	Score=673;Name=lod=725				ID=COSM18852;OCCURENCE=1(breast),1(lung),39(large_intestine)		rs121913333	1	0.935883	N	0.898746	NA	0.725015	NA	1.0	D	1.0	D	3.08	123	110	0.472	174	0	0.000	8.49140605972725734e-34	0.464	---	197,99,97,0.495	150,150,0,0.000	30.051	60
chr5	112175153	112175153	G	T	exonic	APC		stopgain	APC:NM_001127511:exon14:c.G3808T:p.G1270X,APC:NM_000038:exon16:c.G3862T:p.G1288X,APC:NM_001127510:exon17:c.G3862T:p.G1288X	Score=518;Name=lod=170				ID=COSM19577;OCCURENCE=3(large_intestine)			0.02	0.999788	C	0.903851	NA	0.735525	NA	0.999999	D	1.0	D	5.68	112	37	0.248	153	0	0.000	3.34145297657348869e-13	0.595	---	134,100,34,0.254	128,128,0,0.000	10.854	60
chr5	129240663	129240663	C	T	exonic	CHSY3		synonymous SNV	CHSY3:NM_175856:exon1:c.C141T:p.Y47Y	Score=619;Name=lod=436																			76	13	0.146	117	0	0.000	1.07118960470575173e-05	0.692	---	76,63,13,0.171	95,95,0,0.000	4.848	6.022
chr5	136975646	136975646	G	A	exonic	KLHL3		synonymous SNV	KLHL3:NM_001257195:exon7:c.C678T:p.G226G,KLHL3:NM_001257194:exon9:c.C828T:p.G276G,KLHL3:NM_017415:exon9:c.C924T:p.G308G	Score=412;Name=lod=63																			76	15	0.165	125	0	0.000	1.13435775497040528e-06	0.267	---	73,61,12,0.164	102,102,0,0.000	4.804	12.163
chr5	140755345	140755345	C	T	exonic	PCDHGA6		synonymous SNV	PCDHGA6:NM_018919:exon1:c.C1695T:p.P565P,PCDHGA6:NM_032086:exon1:c.C1695T:p.P565P																				501	159	0.241	626	0	0.000	2.24950816131433642e-51	0.591	---	579,441,138,0.238	544,544,0,0.000	43.317	60
chr5	146889237	146889237	G	A	exonic	DPYSL3		nonsynonymous SNV	DPYSL3:NM_001197294:exon1:c.C185T:p.A62V	Score=670;Name=lod=705							0.05												310	90	0.225	391	0	0.000	9.17045085834696346e-30	0.456	---	345,266,78,0.227	323,322,0,0.000	24.335	60
chr5	179193205	179193205	G	A	exonic	MAML1		synonymous SNV	MAML1:NM_014757:exon2:c.G1194A:p.Q398Q	Score=592;Name=lod=338																			168	53	0.240	175	0	0.000	1.72937622577080396e-15	0.547	---	191,146,45,0.236	150,150,0,0.000	12.351	7.181
chr6	32819938	32819938	C	T	exonic	TAP1		synonymous SNV	TAP1:NM_000593:exon3:c.G972A:p.V324V	Score=483;Name=lod=123																			152	22	0.126	231	0	0.000	3.78782229245872312e-09	0.591	---	141,119,21,0.150	185,185,0,0.000	8.080	9.438
chr6	43320118	43320118	G	A	exonic	ZNF318		stopgain	ZNF318:NM_014345:exon5:c.C2767T:p.Q923X	Score=518;Name=lod=170							0	0.999646	C	0.90384	NA	0.7355	NA	0.999989	D	1.0	A	5.28	44	40	0.476	75	0	0.000	2.78710642262148424e-14	0.550	---	70,38,32,0.457	61,60,0,0.000	10.438	60
chr6	44253898	44253898	C	T	exonic	TCTE1		nonsynonymous SNV	TCTE1:NM_182539:exon3:c.G649A:p.E217K	Score=333;Name=lod=30							0.02	0.997877	C	0.98	D	0.47	P	0.999915	D	0.04645	N	4.66	188	38	0.168	230	0	0.000	4.69466896302910418e-13	0.395	---	196,161,35,0.179	184,184,0,0.000	10.729	60
chr6	88049924	88049924	G	A	exonic	SMIM8		nonsynonymous SNV	SMIM8:NM_020425:exon3:c.G226A:p.D76N,SMIM8:NM_001042493:exon4:c.G226A:p.D76N	Score=648;Name=lod=576							0.17	0.992327	C	0.71	T	0.0	B	0.999894	N	0.339196	N	4.55	88	44	0.333	175	0	0.000	5.65589454139846868e-19	0.477	---	106,71,35,0.330	137,137,0,0.000	14.249	60
chr6	108070954	108070954	C	T	exonic	SCML4		nonsynonymous SNV	SCML4:NM_198081:exon3:c.G220A:p.D74N	Score=524;Name=lod=179							0.05	0.972712	C	0.96	D	0.97	D	0.954829	N	0.963944	D	3.8	72	37	0.339	135	0	0.000	1.94305710272393092e-15	0.486	---	82,56,26,0.317	101,101,0,0.000	10.189	13.106
chr6	112671628	112671628	C	A	exonic	RFPL4B		nonsynonymous SNV	RFPL4B:NM_001013734:exon3:c.C718A:p.L240I									0.099763	N	0.51	T	0.085	B	0.967423	N	0.325932	NA	-1.55	62	28	0.311	134	0	0.000	4.28495135553823146e-13	0.500	---	79,53,26,0.329	112,112,0,0.000	11.212	60
chr6	116600647	116600647	G	A	exonic	TSPYL1		nonsynonymous SNV	TSPYL1:NM_003309:exon1:c.C347T:p.A116V								0.16	0.950458	C	0.98	D	0.076	B	0.820791	NA	3.8E-5	N	1.44	205	79	0.278	420	0	0.000	4.0890193802358201e-35	0.519	---	251,176,73,0.293	363,363,0,0.000	31.674	60
chr7	16744174	16744174	G	A	exonic	BZW2		nonsynonymous SNV	BZW2:NM_001159767:exon11:c.G1111A:p.D371N,BZW2:NM_014038:exon11:c.G1111A:p.D371N	Score=519;Name=lod=171							0.06	0.99969	C	0.93	T	0.27	P	1.0	D	0.968751	D	5.39	84	40	0.323	145	0	0.000	6.21281448089949365e-16	0.675	---	106,73,33,0.311	116,116,0,0.000	11.933	13.599
chr7	150648808	150648808	G	A	exonic	KCNH2		nonsynonymous SNV	KCNH2:NM_001204798:exon3:c.C653T:p.A218V,KCNH2:NM_172057:exon3:c.C653T:p.A218V,KCNH2:NM_000238:exon7:c.C1673T:p.A558V,KCNH2:NM_172056:exon7:c.C1673T:p.A558V	Score=631;Name=lod=488							0.11	0.998386	C	0.81	T	0.0060	B	1.0	D	0.991692	D	3.62	229	71	0.237	218	0	0.000	3.95512057843448905e-19	0.465	---	257,195,61,0.238	185,184,0,0.000	15.752	14.116
chr8	77617703	77617703	C	T	exonic	ZFHX4		synonymous SNV	ZFHX4:NM_024721:exon2:c.C1380T:p.C460C	Score=497;Name=lod=139																			213	27	0.112	256	0	0.000	1.38274042684107115e-09	0.407	---	207,184,22,0.107	211,211,0,0.000	6.998	12.431
chr8	107782312	107782312	C	A	exonic	ABRA		nonsynonymous SNV	ABRA:NM_139166:exon1:c.G107T:p.W36L	Score=495;Name=lod=137							0	0.998951	C	1.0	D	0.999	D	1.0	D	0.999956	D	5.31	240	28	0.104	261	0	0.000	3.76581684124963685e-09	0.500	---	237,212,25,0.105	219,219,0,0.000	7.333	8.379
chr8	133090152	133090152	G	A	exonic	HHLA1		nonsynonymous SNV	HHLA1:NM_001145095:exon11:c.C992T:p.S331F								0.01												105	22	0.173	141	0	0.000	2.57494195539342959e-08	0.364	---	107,91,16,0.150	111,111,0,0.000	5.213	60
chr8	146157540	146157540	A	C	exonic	ZNF16		nonsynonymous SNV	ZNF16:NM_006958:exon3:c.T633G:p.C211W,ZNF16:NM_001029976:exon4:c.T633G:p.C211W								0	0.857449	N	0.99	D	0.998	D	0.960273	NA	0.822692	D	0.92	255	33	0.115	230	0	0.000	2.30600302881581714e-09	0.455	---	252,223,29,0.115	195,194,0,0.000	7.403	10.612
chr9	5054648	5054648	C	T	exonic	JAK2		nonsynonymous SNV	JAK2:NM_004972:exon7:c.C700T:p.R234C	Score=766;Name=lod=1737							0	0.998981	C	0.99	D	0.011	B	0.999902	D	0.914383	D	5.34	100	27	0.213	126	0	0.000	3.17428601274502897e-09	0.444	---	104,78,25,0.243	101,101,0,0.000	7.937	60
chr9	7013880	7013880	A	G	exonic	KDM4C		synonymous SNV	KDM4C:NM_001146694:exon14:c.A2061G:p.P687P,KDM4C:NM_001146695:exon14:c.A2061G:p.P687P,KDM4C:NM_001146696:exon14:c.A2127G:p.P709P,KDM4C:NM_015061:exon14:c.A2061G:p.P687P	Score=647;Name=lod=569																			144	30	0.172	154	0	0.000	2.66919169575562895e-09	0.500	---	140,118,22,0.157	108,108,0,0.000	5.774	9.592
chr9	73477973	73477973	C	T	exonic	TRPM3		nonsynonymous SNV	TRPM3:NM_001007471:exon3:c.G313A:p.V105M	Score=610;Name=lod=403		0.000154				rs202229205	0.33	0.984935	C	0.81	T	0.0010	B	0.998313	N	0.039266	N	4.29	71	37	0.343	154	0	0.000	7.48897681155340634e-17	0.378	---	87,56,31,0.356	124,124,0,0.000	13.574	60
chr9	139915478	139915478	C	T	exonic	ABCA2		synonymous SNV	ABCA2:NM_001606:exon9:c.G933A:p.S311S,ABCA2:NM_212533:exon9:c.G1023A:p.S341S																				180	74	0.291	246	0	0.000	3.87040365527697737e-25	0.365	---	207,144,63,0.304	211,211,0,0.000	21.676	60
chr10	7621921	7621921	C	T	exonic	ITIH5		synonymous SNV	ITIH5:NM_032817:exon5:c.G573A:p.T191T,ITIH5:NM_001001851:exon9:c.G1215A:p.T405T,ITIH5:NM_030569:exon9:c.G1215A:p.T405T	Score=507;Name=lod=154		0.000077				rs112675855													122	42	0.256	173	0	0.000	3.31121394680670118e-15	0.429	---	146,108,37,0.255	145,145,0,0.000	11.982	60
chr10	26446416	26446416	C	T	exonic	MYO3A		nonsynonymous SNV	MYO3A:NM_017433:exon26:c.C2971T:p.R991W	Score=523;Name=lod=178							0	0.974416	C	1.0	D	1.0	D	1.0	D	0.999998	D	4.0	85	75	0.469	160	0	0.000	5.45142150151365527e-28	0.320	---	132,69,62,0.473	136,135,0,0.000	23.291	60
chr10	75184882	75184882	C	A	exonic	MSS51		nonsynonymous SNV	MSS51:NM_001024593:exon6:c.G1137T:p.K379N	Score=546;Name=lod=220							0.64	0.985176	C	0.22	T	0.0	B	0.661982	N	0.003243	N	3.84	58	7	0.108	79	0	0.000	0.00316906215913085648	0.429	---	56,50,6,0.107	64,64,0,0.000	2.051	5.957
chr10	106401349	106401349	G	A	exonic	SORCS3		synonymous SNV	SORCS3:NM_014978:exon1:c.G264A:p.E88E	Score=235;Name=lod=12																			117	59	0.335	191	0	0.000	3.34333379184892774e-22	0.661	---	152,103,49,0.322	167,167,0,0.000	17.875	15.955
chr10	117040903	117040903	G	A	exonic	ATRNL1		synonymous SNV	ATRNL1:NM_207303:exon14:c.G2139A:p.E713E	Score=675;Name=lod=736																			68	28	0.292	133	0	0.000	1.87906856484857239e-12	0.536	---	79,56,23,0.291	102,102,0,0.000	9.193	60
chr11	2426171	2426171	G	A	exonic	TRPM5		nonsynonymous SNV	TRPM5:NM_014555:exon24:c.C3494T:p.T1165I								0	0.93317	N	1.0	D	0.686	P	0.885358	NA	0.270907	N	0.894	55	20	0.267	90	0	0.000	2.89936213323251686e-08	0.700	---	66,48,18,0.273	71,71,0,0.000	6.312	9.894
chr11	4510896	4510896	C	T	exonic	OR52K1		nonsynonymous SNV	OR52K1:NM_001005171:exon1:c.C766T:p.P256S	Score=259;Name=lod=15							0	0.998294	C	0.99	D	0.513	P	0.999872	D	0.200788	N	4.34	117	25	0.176	178	0	0.000	4.17871849586231256e-10	0.480	---	127,105,22,0.173	151,151,0,0.000	7.953	14.778
chr11	5809208	5809208	G	T	exonic	OR52N1		nonsynonymous SNV	OR52N1:NM_001001913:exon1:c.C839A:p.A280D	Score=410;Name=lod=62							0	0.999444	C	1.0	D	0.991	D	0.999621	D	0.597123	D	3.87	107	20	0.157	150	0	0.000	7.01162314146643458e-08	0.500	---	111,94,17,0.153	134,134,0,0.000	6.159	11.287
chr11	6292496	6292496	G	A	exonic	CCKBR		nonsynonymous SNV	CCKBR:NM_176875:exon5:c.G1067A:p.R356H	Score=522;Name=lod=177							0.01	0.999402	C	0.95	T	0.94	D	0.999974	D	0.994977	D	4.89	133	49	0.269	245	0	0.000	1.00346361333144233e-20	0.531	---	161,113,48,0.298	217,217,0,0.000	19.834	60
chr11	6415760	6415760	G	T	exonic	SMPD1		nonsynonymous SNV	SMPD1:NM_000543:exon6:c.G1819T:p.A607S,SMPD1:NM_001007593:exon6:c.G1816T:p.A606S	Score=448;Name=lod=88							0.47	0.999463	C	0.58	T	0.0	B	0.986734	N	0.022949	N	4.98	81	56	0.409	179	1	0.006	5.25399618295223304e-23	0.429	1.000	119,71,48,0.403	152,150,1,0.007	18.431	60
chr11	55681965	55681965	A	G	exonic	OR5W2		synonymous SNV	OR5W2:NM_001001960:exon1:c.T94C:p.L32L					ID=COSM1354522;OCCURENCE=1(large_intestine)															59	15	0.203	95	0	0.000	1.7263143715335013e-06	0.400	---	66,53,13,0.197	75,75,0,0.000	4.587	11.579
chr11	60215221	60215221	C	G	exonic	MS4A5		nonsynonymous SNV	MS4A5:NM_023945:exon5:c.C592G:p.Q198E								0.86	0.247725	N	0.0	T	0.0010	B	2.0E-6	N	8.97E-4	N	-0.272	32	14	0.304	68	0	0.000	7.67290214053237025e-07	0.429	---	39,27,11,0.289	53,53,0,0.000	4.595	15.256
chr11	60704759	60704759	C	T	exonic	SLC15A3		nonsynonymous SNV	SLC15A3:NM_016582:exon8:c.G1678A:p.A560T	Score=313;Name=lod=25							0.29	0.91311	N	0.55	T	0.172	P	0.998549	N	0.603181	D	2.29	163	35	0.177	245	0	0.000	9.33165661722946564e-14	0.400	---	159,131,28,0.176	189,189,0,0.000	10.138	14.593
chr11	72407634	72407634	T	G	exonic	ARAP1		nonsynonymous SNV	ARAP1:NM_001135190:exon20:c.A2314C:p.N772H,ARAP1:NM_015242:exon21:c.A2497C:p.N833H,ARAP1:NM_001040118:exon23:c.A3232C:p.N1078H	Score=412;Name=lod=63							0	0.994112	C	0.92	T	0.812	P	1.0	D	0.729692	D	4.16	88	13	0.129	123	0	0.000	2.02730528784861188e-05	0.000	---	103,84,19,0.184	102,101,0,0.000	5.811	7.152
chr11	75905763	75905763	C	T	exonic	WNT11		nonsynonymous SNV	WNT11:NM_004626:exon3:c.G445A:p.G149R	Score=743;Name=lod=1390							0.18	0.99773	C	0.68	T	0.0010	B	0.999993	D	0.996372	D	4.6	158	104	0.397	340	0	0.000	1.50939776713419697e-44	0.500	---	216,134,81,0.377	275,275,0,0.000	33.496	14.398
chr11	108535904	108535904	G	C	exonic	DDX10		synonymous SNV	DDX10:NM_004398:exon1:c.G24C:p.P8P																				123	70	0.363	253	0	0.000	6.05585711660932668e-30	0.557	---	162,108,54,0.333	201,201,0,0.000	21.464	60
chr12	351879	351879	C	T	exonic	SLC6A13		nonsynonymous SNV	SLC6A13:NM_016615:exon4:c.G379A:p.V127I	Score=607;Name=lod=389				ID=COSM1360727;OCCURENCE=1(large_intestine)			0.64	0.006397	N	0.0	T	0.0	B	0.821986	N	6.89E-4	N	-5.48	78	24	0.235	141	0	0.000	1.52881181206801876e-10	0.333	---	89,64,25,0.281	110,110,0,0.000	9.674	12.541
chr12	7077088	7077088	C	T	exonic	PHB2		unknown	UNKNOWN	Score=614;Name=lod=416							0												95	22	0.188	118	0	0.000	7.27348408674846775e-08	0.591	---	100,80,20,0.200	103,102,0,0.000	6.569	13.159
chr12	25398284	25398284	C	A	exonic	KRAS		nonsynonymous SNV	KRAS:NM_004985:exon2:c.G35T:p.G12V,KRAS:NM_033360:exon2:c.G35T:p.G12V	Score=706;Name=lod=982				ID=COSM1140133,COSM520;OCCURENCE=2(pleura),235(ovary),7(breast),3(NS),26(stomach),31(haematopoietic_and_lymphoid_tissue),2(kidney),4(soft_tissue),10(urinary_tract),1162(pancreas),4(peritoneum),5(liver),2(oesophagus),1(autonomic_ganglia),5(gastrointestinal_tract_(site_indeterminate)),19(skin),38(prostate),726(lung),4(cervix),12(thyroid),3(upper_aerodigestive_tract),6(testis),1(eye),2(thymus),3613(large_intestine),1(central_nervous_system),19(small_intestine),101(biliary_tract),90(endometrium)	0.033	rs121913529	0.01	0.998873	C	1.0	D	0.91	D	1.0	D	0.999996	D	5.24	62	31	0.333	107	0	0.000	1.98973856612314005e-12	0.355	---	77,49,28,0.364	83,83,0,0.000	10.247	13.171
chr12	91445213	91445213	G	A	exonic	KERA		synonymous SNV	KERA:NM_007035:exon3:c.C969T:p.R323R	Score=578;Name=lod=299																			55	26	0.321	125	0	0.000	1.63802339921126179e-12	0.462	---	66,44,21,0.323	92,92,0,0.000	9.014	60
chr12	119563241	119563241	C	T	exonic	SRRM4		nonsynonymous SNV	SRRM4:NM_194286:exon7:c.C571T:p.R191W			0.000081		ID=COSM1359215,COSM1359214,COSM1359216;OCCURENCE=1(large_intestine)			0												59	28	0.322	168	0	0.000	2.9303966752532678e-15	0.464	---	73,50,23,0.315	125,125,0,0.000	11.079	60
chr12	122990108	122990108	A	C	exonic	RSRC2		nonsynonymous SNV	RSRC2:NM_023012:exon10:c.T1271G:p.F424C	Score=701;Name=lod=941							0	0.99906	C	1.0	D	0.999	D	1.0	D	0.99878	D	5.57	70	10	0.125	98	0	0.000	0.000242060076912454827	1.000	---	86,63,23,0.267	84,84,0,0.000	7.350	8.374
chr12	122990109	122990109	A	C	exonic	RSRC2		nonsynonymous SNV	RSRC2:NM_023012:exon10:c.T1270G:p.F424V	Score=701;Name=lod=941							0	0.99906	C	1.0	D	0.999	D	1.0	D	0.998095	D	5.57	71	16	0.184	97	0	0.000	2.80939810940569179e-06	1.000	---	86,62,24,0.279	85,85,0,0.000	7.734	7.844
chr12	130884319	130884319	A	C	exonic	RIMBP2		nonsynonymous SNV	RIMBP2:NM_015347:exon18:c.T3037G:p.F1013V	Score=568;Name=lod=272				ID=COSM430733;OCCURENCE=1(breast),1(oesophagus)			0	0.997607	C	1.0	D	0.999	D	1.0	D	0.999999	D	4.67	100	20	0.167	139	0	0.000	8.24707647521544735e-08	0.450	---	93,76,17,0.183	101,101,0,0.000	5.791	7.024
chr13	43900569	43900569	G	A	exonic	ENOX1		stopgain	ENOX1:NM_001127615:exon10:c.C1129T:p.R377X,ENOX1:NM_001242863:exon10:c.C1129T:p.R377X,ENOX1:NM_017993:exon10:c.C1129T:p.R377X	Score=769;Name=lod=1779							0.9	0.99976	C	0.903849	NA	0.73552	NA	1.0	D	1.0	A	4.49	97	12	0.110	95	0	0.000	0.00047192233171635013	0.583	---	87,77,10,0.115	69,69,0,0.000	2.606	6.898
chr13	114322031	114322031	C	A	exonic	GRK1		synonymous SNV	GRK1:NM_002929:exon1:c.C330A:p.I110I	Score=432;Name=lod=76																			256	75	0.227	305	0	0.000	6.21010172981762813e-24	0.427	---	303,231,72,0.238	255,255,0,0.000	20.942	60
chr14	102506742	102506742	G	A	exonic	DYNC1H1		nonsynonymous SNV	DYNC1H1:NM_001376:exon63:c.G11860A:p.D3954N	Score=407;Name=lod=60							0.73	0.999719	C	0.48	T	0.0	B	1.0	D	0.998732	D	5.47	112	49	0.304	156	1	0.006	1.67403974484233383e-15	0.327	1.000	143,95,48,0.336	143,142,1,0.007	14.741	60
chr15	25959239	25959239	C	T	exonic	ATP10A		synonymous SNV	ATP10A:NM_024490:exon10:c.G1926A:p.P642P	Score=309;Name=lod=24																			122	82	0.402	319	0	0.000	1.33102660109680534e-39	0.244	---	171,98,73,0.427	259,259,0,0.000	34.306	60
chr15	28273022	28273022	C	G	exonic	OCA2		nonsynonymous SNV	OCA2:NM_000275:exon4:c.G510C:p.K170N								0.02	0.158478	N	0.47	T	0.0010	B	0.920183	N	0.225703	N	-2.48	81	47	0.367	170	0	0.000	1.5819649912819729e-20	0.532	---	103,65,38,0.369	137,137,0,0.000	16.025	8.066
chr15	42977254	42977254	A	C	exonic	STARD9		nonsynonymous SNV	STARD9:NM_020759:exon23:c.A3478C:p.K1160Q								0.36												120	32	0.211	176	0	0.000	2.90529420653194876e-12	0.344	---	137,106,31,0.226	152,152,0,0.000	10.922	15.955
chr15	54590024	54590024	A	G	exonic	UNC13C		nonsynonymous SNV	UNC13C:NM_001080534:exon10:c.A4004G:p.K1335R	Score=539;Name=lod=206				ID=COSM1231759,COSM1231758;OCCURENCE=1(large_intestine)			0.05												33	14	0.298	53	0	0.000	7.73178124790989358e-06	0.643	---	40,30,10,0.250	47,47,0,0.000	3.674	7.591
chr16	57805245	57805245	G	C	exonic	KIFC3		nonsynonymous SNV	KIFC3:NM_001130099:exon5:c.C213G:p.D71E,KIFC3:NM_001130100:exon6:c.C630G:p.D210E,KIFC3:NM_005550:exon6:c.C630G:p.D210E	Score=592;Name=lod=338							1	0.999422	C	0.0	T	0.0010	B	0.999749	D	0.005782	N	4.92	191	29	0.132	233	0	0.000	2.90110395600701745e-10	0.483	---	191,166,25,0.131	199,199,0,0.000	8.123	11.225
chr16	69988383	69988383	C	T	exonic	CLEC18A		synonymous SNV	CLEC18A:NM_001136214:exon4:c.C363T:p.V121V,CLEC18A:NM_001271197:exon4:c.C363T:p.V121V,CLEC18A:NM_182619:exon4:c.C363T:p.V121V		Score=0.990978;Name=chr16:70200495																		222	61	0.216	392	0	0.000	1.42119398985277069e-25	0.557	---	259,198,61,0.236	338,338,0,0.000	24.085	13.861
chr17	7577094	7577094	G	A	exonic	TP53		nonsynonymous SNV	TP53:NM_001126115:exon4:c.C448T:p.R150W,TP53:NM_001126116:exon4:c.C448T:p.R150W,TP53:NM_001126117:exon4:c.C448T:p.R150W,TP53:NM_001276697:exon4:c.C367T:p.R123W,TP53:NM_001276698:exon4:c.C367T:p.R123W,TP53:NM_001276699:exon4:c.C367T:p.R123W,TP53:NM_001126118:exon7:c.C727T:p.R243W,TP53:NM_000546:exon8:c.C844T:p.R282W,TP53:NM_001126112:exon8:c.C844T:p.R282W,TP53:NM_001126113:exon8:c.C844T:p.R282W,TP53:NM_001126114:exon8:c.C844T:p.R282W,TP53:NM_001276695:exon8:c.C727T:p.R243W,TP53:NM_001276696:exon8:c.C727T:p.R243W,TP53:NM_001276760:exon8:c.C727T:p.R243W,TP53:NM_001276761:exon8:c.C727T:p.R243W	Score=481;Name=lod=120		0.000154		ID=COSM99925,COSM10704;OCCURENCE=1(salivary_gland),4(vulva),16(ovary),1(bone),21(breast),1(NS),7(haematopoietic_and_lymphoid_tissue),32(stomach),12(urinary_tract),10(pancreas),2(peritoneum),4(liver),52(oesophagus),1(autonomic_ganglia),9(skin),2(prostate),19(lung),2(thyroid),29(upper_aerodigestive_tract),131(large_intestine),28(central_nervous_system),4(biliary_tract),3(endometrium)		rs28934574	0	0.873535	N	1.0	D	1.0	D	1.0	D	1.0	D	0.419	56	47	0.456	157	1	0.006	1.07326283305603766e-21	0.447	1.000	79,45,34,0.430	124,123,1,0.008	14.895	15.955
chr17	11461088	11461088	G	A	exonic	SHISA6		nonsynonymous SNV	SHISA6:NM_001173461:exon4:c.G970A:p.E324K,SHISA6:NM_001173462:exon5:c.G1066A:p.E356K,SHISA6:NM_207386:exon6:c.G1123A:p.E375K	Score=519;Name=lod=171							0.02												56	55	0.495	223	0	0.000	4.30300070627916711e-32	0.727	---	98,45,53,0.541	199,199,0,0.000	31.014	60
chr17	72246141	72246141	G	T	exonic	TTYH2		nonsynonymous SNV	TTYH2:NM_052869:exon3:c.G34T:p.A12S,TTYH2:NM_032646:exon9:c.G997T:p.A333S	Score=422;Name=lod=69							0.11	0.979537	C	0.87	T	0.0080	B	1.0	D	0.298126	N	3.11	86	18	0.173	151	0	0.000	3.78026238645117633e-08	0.556	---	83,70,13,0.157	122,122,0,0.000	5.366	13.043
chr18	7888130	7888130	G	T	exonic	PTPRM		nonsynonymous SNV	PTPRM:NM_001105244:exon3:c.G223T:p.G75W,PTPRM:NM_002845:exon3:c.G223T:p.G75W	Score=371;Name=lod=43								0.999648	C	0.99	D	0.356	P	1.0	D	0.999095	D	5.3	82	37	0.311	158	0	0.000	6.17688757105295125e-16	0.622	---	103,69,34,0.330	129,129,0,0.000	13.559	12.011
chr18	72109231	72109231	G	A	exonic	FAM69C		stopgain	FAM69C:NM_001044369:exon3:c.C997T:p.R333X			0.000082					0.77	0.953014	C	0.90131	NA	0.714776	NA	0.925909	N	1.0	D	0.691	97	44	0.312	156	0	0.000	8.91607184172573751e-17	0.523	---	120,84,36,0.300	125,125,0,0.000	12.530	60
chr18	76753566	76753566	C	T	exonic	SALL3		synonymous SNV	SALL3:NM_171999:exon2:c.C1575T:p.S525S																				192	40	0.172	278	0	0.000	2.80485724629370779e-15	0.475	---	207,169,38,0.184	248,248,0,0.000	13.880	14.778
chr19	4182513	4182513	C	T	exonic	SIRT6		synonymous SNV	SIRT6:NM_001193285:exon1:c.G24A:p.G8G,SIRT6:NM_016539:exon1:c.G24A:p.G8G	Score=583;Name=lod=311																			111	48	0.302	159	0	0.000	5.3716967625467763e-17	0.500	---	134,94,40,0.299	134,134,0,0.000	13.230	60
chr19	9763674	9763674	G	C	exonic	ZNF562		nonsynonymous SNV	ZNF562:NM_017656:exon4:c.C1016G:p.T339S,ZNF562:NM_001130031:exon6:c.C1232G:p.T411S,ZNF562:NM_001130032:exon6:c.C1232G:p.T411S		Score=0.901768;Name=chr19:9799519						0.78	0.754546	N	0.58	T	0.968	D	0.828396	NA	0.001002	N	0.0244	97	30	0.236	153	0	0.000	6.03673466998979357e-12	0.667	---	114,86,26,0.232	133,133,0,0.000	9.610	60
chr19	11311677	11311677	G	A	exonic	DOCK6		nonsynonymous SNV	DOCK6:NM_020812:exon45:c.C5740T:p.R1914W	Score=486;Name=lod=126							0.19												140	68	0.327	195	0	0.000	7.64492306850156061e-23	0.382	---	178,118,60,0.337	154,154,0,0.000	18.622	60
chr19	34003637	34003637	C	T	exonic	PEPD		synonymous SNV	PEPD:NM_000285:exon2:c.G63A:p.A21A,PEPD:NM_001166056:exon2:c.G63A:p.A21A,PEPD:NM_001166057:exon2:c.G63A:p.A21A																				81	28	0.257	163	0	0.000	7.13442818658110131e-13	0.250	---	88,63,25,0.284	124,124,0,0.000	10.548	60
chr19	46307926	46307926	C	T	exonic	RSPH6A		nonsynonymous SNV	RSPH6A:NM_030785:exon3:c.G1237A:p.V413M			0.000461	0.0005			rs138579958	0.17	0.812513	N	0.83	T	0.0030	B	0.964651	N	0.012914	N	0.807	135	71	0.345	210	0	0.000	1.31040645485131837e-25	0.437	---	178,114,64,0.360	165,165,0,0.000	21.041	60
chr19	49657264	49657264	T	A	exonic	HRC		stopgain	HRC:NM_002152:exon1:c.A1231T:p.K411X								0.14	0.00944	N	0.829001	NA	0.526087	NA	0.735788	NA	1.0	A	-6.51	102	52	0.338	157	0	0.000	7.02691851883251922e-19	0.404	---	131,87,44,0.336	132,132,0,0.000	15.218	60
chr19	56001755	56001755	C	T	exonic	SSC5D		nonsynonymous SNV	SSC5D:NM_001144950:exon5:c.C566T:p.T189M,SSC5D:NM_001195267:exon5:c.C566T:p.T189M					ID=COSM1396594;OCCURENCE=1(large_intestine)			0.01												39	9	0.188	53	0	0.000	0.00080308902790681888	0.444	---	37,29,8,0.216	39,39,0,0.000	2.689	6.171
chr19	56274429	56274429	G	A	exonic	RFPL4A		nonsynonymous SNV	RFPL4A:NM_001145014:exon3:c.G752A:p.R251H		Score=0.976927;Name=chr19:56277496						0.09												188	77	0.291	366	0	0.000	5.63120268561465736e-33	0.429	---	211,151,60,0.284	287,287,0,0.000	24.812	60
chr20	44279177	44279177	C	A	exonic	WFDC11		synonymous SNV	WFDC11:NM_147197:exon3:c.G63T:p.L21L																				47	55	0.539	87	0	0.000	1.49743242715891623e-19	0.509	---	85,40,44,0.524	67,67,0,0.000	14.169	60
chr20	44512472	44512472	C	T	exonic	ZSWIM1		nonsynonymous SNV	ZSWIM1:NM_080603:exon2:c.C1241T:p.P414L								0.14	0.934992	N	0.77	T	0.206	P	0.751582	U	0.006197	N	2.19	233	37	0.137	229	0	0.000	4.29070656664235874e-11	0.432	---	241,205,36,0.149	195,195,0,0.000	9.686	14.097
chr20	50769714	50769714	C	T	exonic	ZFP64		synonymous SNV	ZFP64:NM_022088:exon5:c.G855A:p.S285S,ZFP64:NM_018197:exon6:c.G1017A:p.S339S,ZFP64:NM_199426:exon6:c.G1011A:p.S337S																				266	92	0.257	333	0	0.000	8.50635810978520906e-30	0.467	---	320,241,78,0.245	290,290,0,0.000	24.123	60
chr21	30329085	30329085	T	G	exonic	LTN1		synonymous SNV	LTN1:NM_015565:exon16:c.A3216C:p.I1072I	Score=460;Name=lod=99																			62	12	0.162	66	0	0.000	0.000368642481510720475	0.500	---	60,50,10,0.167	54,53,0,0.000	2.816	4.853
chr22	28702591	28702591	C	T	exonic	TTC28		nonsynonymous SNV	TTC28:NM_001145418:exon3:c.G422A:p.R141H	Score=722;Name=lod=1141							0.26												77	42	0.353	153	0	0.000	6.06637075674490653e-18	0.452	---	94,63,31,0.330	121,121,0,0.000	12.579	12.843
chr22	36661827	36661827	T	G	exonic	APOL1		synonymous SNV	APOL1:NM_001136541:exon5:c.T891G:p.G297G,APOL1:NM_001136540:exon6:c.T945G:p.G315G,APOL1:NM_003661:exon6:c.T945G:p.G315G,APOL1:NM_145343:exon7:c.T993G:p.G331G		Score=0.909256;Name=chr22:36620662																		149	20	0.118	246	0	0.000	7.7730616392919447e-09	0.000	---	194,154,40,0.206	211,211,0,0.000	13.800	10.773
chr22	37325516	37325516	C	T	exonic	CSF2RB		nonsynonymous SNV	CSF2RB:NM_000395:exon5:c.C464T:p.A155V								0.12	0.97412	C	0.97	D	0.1	B	0.42032	N	0.015353	N	1.02	143	67	0.319	253	0	0.000	1.06102233739644526e-26	0.582	---	179,118,61,0.341	210,208,0,0.000	23.303	60
chrX	7811708	7811708	C	T	exonic	VCX		nonsynonymous SNV	VCX:NM_013452:exon3:c.C272T:p.P91L		Score=0.940817;Name=chrX:6445602						0	0.036389	N	0.75	T	0.230818	NA	0.587617	NA	0.001512	N	-0.313	18	18	0.500	53	0	0.000	2.99339640457810161e-09	0.389	---	26,14,12,0.462	36,36,0,0.000	5.350	3.254
chrX	8138221	8138221	G	A	exonic	VCX2		nonsynonymous SNV	VCX2:NM_016378:exon3:c.C272T:p.P91L		Score=0.944861;Name=chrX:6446755	0.000192				rs141793192	0	0.025761	N	1.0	D	0.368702	NA	0.582501	NA	0.004902	N	-0.297	55	42	0.433	94	0	0.000	1.83849566138177774e-15	0.381	---	82,50,32,0.390	84,84,0,0.000	11.461	3.437
chrX	37026676	37026676	C	T	exonic	FAM47C		nonsynonymous SNV	FAM47C:NM_001013736:exon1:c.C193T:p.P65S		Score=0.896562;Name=chrX:34955671						0.5	0.100918	N	0.35	T	0.999	D	0.660506	NA	0.004591	N	-0.691	55	137	0.714	205	0	0.000	1.06234721263158638e-61	0.547	---	164,49,115,0.701	173,172,0,0.000	50.154	60
chrX	77266953	77266953	C	T	exonic	ATP7A		nonsynonymous SNV	ATP7A:NM_000052:exon9:c.C1954T:p.R652W			0.000189					0.03	0.845841	N	0.97	D	0.914	D	0.946821	N	0.643426	D	1.18	19	31	0.620	62	0	0.000	7.34064710588864356e-15	0.774	---	43,17,26,0.605	54,54,0,0.000	11.823	60
chrX	77268393	77268393	C	T	exonic	ATP7A		synonymous SNV	ATP7A:NM_000052:exon10:c.C2190T:p.Y730Y	Score=544;Name=lod=216																			25	13	0.342	39	0	0.000	2.9469695385684149e-05	0.692	---	35,24,11,0.314	36,36,0,0.000	3.788	13.593
chrX	120009392	120009392	T	G	exonic	CT47B1		nonsynonymous SNV	CT47B1:NM_001145718:exon1:c.A133C:p.M45L		Score=0.977351;Name=chrX:120086644						0.3												128	172	0.573	516	0	0.000	3.39025663053844674e-94	0.029	---	285,116,169,0.593	469,462,2,0.004	60.000	5.481