Chr	Start	End	Ref	Alt	Func.refGene	Gene.refGene	GeneDetail.refGene	ExonicFunc.refGene	AAChange.refGene	phastConsElements46way	genomicSuperDups	esp6500si_all	1000g2012apr_all	cosmic65	nci60	snp137	avsift	LJB_PhyloP	LJB_PhyloP_Pred	LJB_SIFT	LJB_SIFT_Pred	LJB_PolyPhen2	LJB_PolyPhen2_Pred	LJB_LRT	LJB_LRT_Pred	LJB_MutationTaster	LJB_MutationTaster_Pred	LJB_GERP++	tumor_ref	tumor_var	misRate_tumor	normal_ref	normal_var	misRate_normal	p-value(Fisher)	strandRatio_tumor	strandRatio_normal	tumor_realign(total,ref,alt,freq)	normal_realign(total,ref,alt,freq)	p-value(Realaign)	p-value(EBcall)
chr1	35223213	35223213	C	T	exonic	GJB5		synonymous SNV	GJB5:NM_005268:exon2:c.C282T:p.H94H	Score=534;Name=lod=198																			77	59	0.434	246	0	0.000	1.29605328162802018e-31	0.492	---	111,65,46,0.414	204,204,0,0.000	24.091	60
chr1	75038108	75038108	G	T	exonic	C1orf173		nonsynonymous SNV	C1orf173:NM_001002912:exon14:c.C3286A:p.Q1096K								0	0.982462	C	1.0	D	0.02	B	0.825916	NA	4.3E-5	N	2.31	184	82	0.308	248	0	0.000	3.0342353049261239e-27	0.488	---	231,160,71,0.307	202,201,1,0.005	20.095	60
chr2	26951175	26951175	C	T	exonic	KCNK3		synonymous SNV	KCNK3:NM_002246:exon2:c.C924T:p.S308S	Score=742;Name=lod=1378																			185	79	0.299	229	0	0.000	9.41704798033742697e-25	0.380	---	232,162,70,0.302	199,199,0,0.000	21.072	60
chr2	44429044	44429044	G	A	exonic	PPM1B		nonsynonymous SNV	PPM1B:NM_001033556:exon2:c.G706A:p.E236K,PPM1B:NM_001033557:exon2:c.G706A:p.E236K,PPM1B:NM_002706:exon2:c.G706A:p.E236K,PPM1B:NM_177968:exon2:c.G706A:p.E236K	Score=720;Name=lod=1121							0	0.999667	C	1.0	D	0.849	P	0.999998	D	0.999666	D	5.33	168	71	0.297	208	0	0.000	1.69810088345808897e-22	0.521	---	205,142,63,0.307	172,172,0,0.000	18.783	60
chr2	99977644	99977644	A	G	exonic	EIF5B		nonsynonymous SNV	EIF5B:NM_015904:exon4:c.A280G:p.K94E	Score=575;Name=lod=289							0.02	0.998709	C	1.0	D	0.537433	NA	0.858099	NA	0.009251	N	5.26	114	55	0.325	177	0	0.000	3.51597245627482238e-20	0.764	---	144,96,48,0.333	148,148,0,0.000	16.814	13.476
chr2	175614763	175614763	C	T	exonic	CHRNA1		nonsynonymous SNV	CHRNA1:NM_000079:exon7:c.G913A:p.V305I,CHRNA1:NM_001039523:exon8:c.G988A:p.V330I	Score=559;Name=lod=249				ID=COSM1201111;OCCURENCE=1(large_intestine)		rs137852804	0	0.998415	C	0.99	D	0.974	D	0.999995	D	0.997265	D	4.93	162	20	0.110	182	0	0.000	5.49223107268673002e-07	0.450	---	146,131,15,0.103	144,144,0,0.000	4.378	9.807
chr2	197298070	197298070	C	A	exonic	HECW2		nonsynonymous SNV	HECW2:NM_020760:exon2:c.G78T:p.E26D	Score=470;Name=lod=108							0.49	0.999088	C	0.67	T	0.075	B	0.999348	N	0.152361	N	4.92	149	50	0.251	218	0	0.000	2.17654711656614335e-18	0.380	---	153,113,40,0.261	175,175,0,0.000	14.604	60
chr2	202151236	202151236	G	A	exonic	CASP8		synonymous SNV	CASP8:NM_033356:exon8:c.G1314A:p.K438K,CASP8:NM_001080124:exon9:c.G1314A:p.K438K,CASP8:NM_001080125:exon9:c.G1536A:p.K512K,CASP8:NM_001228:exon10:c.G1410A:p.K470K,CASP8:NM_033355:exon10:c.G1359A:p.K453K																				68	49	0.419	104	0	0.000	7.12434608925776277e-17	0.469	---	90,53,37,0.411	83,83,0,0.000	12.454	60
chr3	2967417	2967417	G	T	exonic	CNTN4		nonsynonymous SNV	CNTN4:NM_001206956:exon4:c.G328T:p.V110F,CNTN4:NM_175613:exon4:c.G328T:p.V110F,CNTN4:NM_001206955:exon12:c.G1312T:p.V438F,CNTN4:NM_175607:exon13:c.G1312T:p.V438F	Score=441;Name=lod=83							0.33	0.991371	C	0.9	T	0.067	B	0.913657	N	0.619201	D	3.81	103	38	0.270	141	0	0.000	4.05738679048900318e-13	0.447	---	107,78,28,0.264	111,110,1,0.009	8.338	15.256
chr3	9102014	9102014	C	T	exonic	SRGAP3		synonymous SNV	SRGAP3:NM_001033117:exon6:c.G702A:p.L234L,SRGAP3:NM_014850:exon6:c.G702A:p.L234L	Score=494;Name=lod=136																			135	70	0.341	214	0	0.000	1.27005546648454724e-25	0.386	---	181,122,58,0.322	190,189,0,0.000	20.524	60
chr3	38040932	38040932	T	C	splicing	VILL	NM_015873:exon10:c.1182+2T>C			Score=454;Name=lod=93																			89	39	0.305	111	0	0.000	1.17986740963974146e-12	0.385	---	97,69,28,0.289	83,83,0,0.000	8.330	60
chr3	38307611	38307611	G	A	exonic	SLC22A13		nonsynonymous SNV	SLC22A13:NM_004256:exon1:c.G260A:p.R87Q	Score=426;Name=lod=72							0.15	0.845129	N	0.46	T	0.065	B	0.984518	N	0.092594	N	-0.456	189	39	0.171	201	0	0.000	4.62385757779009014e-12	0.538	---	197,162,35,0.178	169,169,0,0.000	10.026	15.654
chr3	121202299	121202299	G	A	exonic	POLQ		synonymous SNV	POLQ:NM_199420:exon18:c.C5904T:p.I1968I	Score=596;Name=lod=352				ID=COSM1262701;OCCURENCE=1(oesophagus)															79	29	0.269	84	0	0.000	1.06105682574637512e-08	0.655	---	88,64,24,0.273	70,70,0,0.000	6.775	60
chr3	154146834	154146834	C	T	exonic	GPR149		nonsynonymous SNV	GPR149:NM_001038705:exon1:c.G571A:p.V191I	Score=441;Name=lod=83							0.97	0.998639	C	0.0	T	0.194	P	0.99893	N	0.021339	N	4.73	144	54	0.273	246	0	0.000	1.13136236976346663e-21	0.574	---	171,124,47,0.275	206,206,0,0.000	17.872	60
chr3	184870463	184870463	C	A	exonic	C3orf70		nonsynonymous SNV	C3orf70:NM_001025266:exon1:c.G149T:p.G50V	Score=705;Name=lod=974							0.01	0.994416	C	0.99	D	0.936	D	1.0	D	0.999684	D	3.24	124	41	0.248	187	1	0.005	3.60998971310502411e-14	0.585	1.000	143,107,36,0.252	166,164,1,0.006	11.807	13.258
chr4	2460909	2460909	G	A	exonic	LOC402160		nonsynonymous SNV	LOC402160:NM_001193282:exon13:c.G1379A:p.R460H																				138	70	0.337	199	2	0.010	2.6936233865171257e-21	0.457	0.500	168,108,60,0.357	162,161,1,0.006	18.750	60
chr4	3319170	3319170	G	A	exonic	RGS12		nonsynonymous SNV	RGS12:NM_002926:exon2:c.G1273A:p.G425S,RGS12:NM_198229:exon2:c.G1273A:p.G425S	Score=543;Name=lod=215							0.01	0.998667	C	1.0	D	0.991	D	1.0	D	0.987687	D	4.29	226	85	0.273	268	1	0.004	9.91671988241779723e-25	0.494	0.000	268,190,77,0.288	233,232,1,0.004	21.816	60
chr4	126237923	126237923	C	T	exonic	FAT4		synonymous SNV	FAT4:NM_024582:exon1:c.C357T:p.T119T																				282	92	0.246	346	0	0.000	1.47796052456019063e-29	0.587	---	320,240,80,0.250	306,305,0,0.000	25.654	60
chr4	153249384	153249384	C	T	exonic	FBXW7		nonsynonymous SNV	FBXW7:NM_001013415:exon8:c.G1040A:p.R347H,FBXW7:NM_018315:exon8:c.G1154A:p.R385H,FBXW7:NM_033632:exon9:c.G1394A:p.R465H	Score=531;Name=lod=192				ID=COSM117308,COSM117310,COSM22965,COSM1149856,COSM117309;OCCURENCE=1(ovary),33(haematopoietic_and_lymphoid_tissue),1(lung),1(cervix),17(large_intestine),1(biliary_tract),5(endometrium)			0	0.999208	C	1.0	D	1.0	D	1.0	D	0.999991	D	5.58	103	37	0.264	117	0	0.000	2.56688674676555346e-11	0.676	---	115,84,31,0.270	99,98,0,0.000	9.174	60
chr5	112164586	112164586	C	T	exonic	APC		stopgain	APC:NM_001127511:exon12:c.C1606T:p.R536X,APC:NM_000038:exon14:c.C1660T:p.R554X,APC:NM_001127510:exon15:c.C1660T:p.R554X	Score=618;Name=lod=432				ID=COSM19040;OCCURENCE=1(ovary),10(large_intestine)		rs137854573	1	0.202288	N	0.840145	NA	0.604364	NA	1.0	D	1.0	A	1.89	24	34	0.586	92	0	0.000	2.24993658195601521e-18	0.647	---	45,20,25,0.556	75,75,0,0.000	13.120	60
chr5	139216753	139216753	C	T	exonic	PSD2		nonsynonymous SNV	PSD2:NM_032289:exon11:c.C1595T:p.T532M	Score=329;Name=lod=29							0	0.969099	C	1.0	D	0.959	D	1.0	D	0.999716	D	3.2	105	47	0.309	113	0	0.000	1.36781033590934628e-13	0.553	---	132,89,43,0.326	96,96,0,0.000	11.667	60
chr5	140202545	140202545	G	T	exonic	PCDHA5		nonsynonymous SNV	PCDHA5:NM_018908:exon1:c.G1185T:p.K395N,PCDHA5:NM_031501:exon1:c.G1185T:p.K395N	Score=355;Name=lod=37							0	0.8896	N	0.99	D	0.511691	NA	0.826525	NA	0.003827	N	1.16	415	139	0.251	506	0	0.000	8.54973530076556149e-44	0.626	---	460,342,117,0.255	436,436,0,0.000	37.467	12.986
chr5	140554213	140554213	C	T	exonic	PCDHB7		synonymous SNV	PCDHB7:NM_018940:exon1:c.C1797T:p.N599N	Score=633;Name=lod=496	Score=0.959662;Name=chr5:140475628																		962	437	0.312	1236	1	0.001	5.66224008612463756e-135	0.531	1.000	1186,819,367,0.309	1070,1068,1,0.001	60.000	5.808
chr5	140563963	140563963	C	T	exonic	PCDHB16		nonsynonymous SNV	PCDHB16:NM_020957:exon1:c.C1829T:p.T610M	Score=593;Name=lod=343	Score=0.947966;Name=chr5:140604338						0	0.82901	N	1.0	D	1.0	D	0.998375	N	0.124345	N	1.24	563	121	0.177	630	0	0.000	2.23022555592040822e-37	0.636	---	688,561,127,0.185	634,633,0,0.000	38.606	3.145
chr5	140720645	140720645	G	A	exonic	PCDHGA2		nonsynonymous SNV	PCDHGA2:NM_018915:exon1:c.G2107A:p.V703I,PCDHGA2:NM_032009:exon1:c.G2107A:p.V703I	Score=403;Name=lod=58							0.22	0.958603	C	0.5	T	0.271196	NA	0.961983	U	4.75E-4	N	0.297	479	234	0.328	767	0	0.000	2.81352498576086091e-85	0.487	---	625,415,209,0.335	638,638,0,0.000	60.000	60
chr5	179225365	179225365	C	T	exonic	MGAT4B		nonsynonymous SNV	MGAT4B:NM_054013:exon12:c.G1537A:p.D513N,MGAT4B:NM_014275:exon13:c.G1492A:p.D498N	Score=259;Name=lod=15							0.06	0.997534	C	0.99	D	0.132	B	1.0	D	0.999868	D	4.52	78	100	0.562	202	0	0.000	9.78333056274217572e-43	0.460	---	163,66,97,0.595	166,166,0,0.000	38.747	60
chr6	43155738	43155738	C	T	exonic	CUL9		synonymous SNV	CUL9:NM_015089:exon7:c.C1869T:p.A623A				0.0005			rs138491396													143	60	0.296	210	0	0.000	1.68917414398612468e-21	0.500	---	170,118,52,0.306	178,178,0,0.000	18.229	60
chr6	76022425	76022425	T	A	exonic	FILIP1		synonymous SNV	FILIP1:NM_015687:exon5:c.A3123T:p.P1041P	Score=540;Name=lod=208																			173	56	0.245	233	0	0.000	1.77878273761865954e-19	0.554	---	191,140,50,0.263	192,192,0,0.000	16.789	60
chr6	100838498	100838498	C	T	exonic	SIM1		synonymous SNV	SIM1:NM_005068:exon11:c.G2040A:p.S680S																				120	61	0.337	234	0	0.000	1.12177764257908777e-25	0.475	---	157,104,53,0.338	196,196,0,0.000	21.189	60
chr6	123377105	123377105	A	G	exonic	CLVS2		nonsynonymous SNV	CLVS2:NM_001010852:exon5:c.A830G:p.N277S	Score=336;Name=lod=31							0.18	0.86449	N	0.36	T	0.0020	B	0.999968	N	0.705017	D	2.45	61	44	0.419	166	0	0.000	7.62401088016046858e-22	0.477	---	86,50,36,0.419	136,135,0,0.000	17.187	60
chr7	103202300	103202300	T	A	exonic	RELN		nonsynonymous SNV	RELN:NM_005045:exon35:c.A5311T:p.M1771L,RELN:NM_173054:exon35:c.A5311T:p.M1771L	Score=582;Name=lod=309							0.18	0.897913	N	0.0	T	0.999	D	1.0	N	0.760377	D	3.67	111	42	0.275	148	0	0.000	2.17649823141507851e-14	0.595	---	140,99,41,0.293	131,131,0,0.000	13.191	60
chr7	138487694	138487694	C	A	exonic	TMEM213		nonsynonymous SNV	TMEM213:NM_001085429:exon3:c.C204A:p.D68E								0.03												163	36	0.181	224	0	0.000	2.57831857637617573e-13	0.556	---	171,139,32,0.187	182,182,0,0.000	10.789	60
chr8	39678550	39678550	C	A	exonic	ADAM2		nonsynonymous SNV	ADAM2:NM_001464:exon6:c.G484T:p.D162Y								0.01	0.771456	N	0.98	D	0.665	P	0.856345	NA	0.379077	N	1.75	72	18	0.200	99	0	0.000	5.90992244063739096e-07	0.778	---	74,59,15,0.203	79,79,0,0.000	5.085	7.116
chr8	52370109	52370109	C	T	exonic	PXDNL		nonsynonymous SNV	PXDNL:NM_144651:exon9:c.G931A:p.A311T	Score=355;Name=lod=37		0.000164				rs201353036	0.12												91	116	0.560	133	0	0.000	9.97600600274080024e-34	0.586	---	171,76,94,0.553	108,108,0,0.000	26.339	60
chr8	53574144	53574144	A	G	exonic	RB1CC1		nonsynonymous SNV	RB1CC1:NM_001083617:exon9:c.T1309C:p.C437R,RB1CC1:NM_014781:exon9:c.T1309C:p.C437R	Score=741;Name=lod=1370							0	0.998654	C	0.99	D	0.999	D	1.0	D	0.999211	D	5.21	129	144	0.527	164	0	0.000	7.38973478044170732e-39	0.521	---	215,104,110,0.514	131,131,0,0.000	29.299	60
chr8	53852934	53852934	G	A	exonic	NPBWR1		nonsynonymous SNV	NPBWR1:NM_005285:exon1:c.G467A:p.R156H	Score=374;Name=lod=44							0.01	0.999551	C	0.99	D	0.941	D	0.989083	N	0.270135	N	3.2	473	132	0.218	346	0	0.000	3.90621218683718993e-29	0.538	---	515,402,112,0.218	305,305,0,0.000	24.648	60
chr8	72966067	72966067	G	T	exonic	TRPA1		nonsynonymous SNV	TRPA1:NM_007332:exon13:c.C1565A:p.S522Y	Score=602;Name=lod=372							0	0.999422	C	0.887232	NA	0.707	P	0.999999	D	0.828243	D	4.92	72	98	0.576	133	0	0.000	4.57665940458645333e-33	0.316	---	146,61,85,0.582	107,107,0,0.000	26.920	60
chr8	105026793	105026793	G	A	exonic	RIMS2		nonsynonymous SNV	RIMS2:NM_014677:exon17:c.G2726A:p.R909Q,RIMS2:NM_001100117:exon19:c.G3284A:p.R1095Q	Score=642;Name=lod=542							0	0.999643	C	1.0	D	0.982	D	0.992352	NA	0.78344	NA	5.28	77	85	0.525	142	0	0.000	3.97936728219947771e-30	0.518	---	128,59,69,0.539	112,112,0,0.000	24.062	60
chr9	32633225	32633225	G	A	exonic	TAF1L		nonsynonymous SNV	TAF1L:NM_153809:exon1:c.C2353T:p.R785W	Score=930;Name=lod=8007								0.941794	N	1.0	D	1.0	D	0.999999	D	0.999981	D	0.583	494	58	0.105	361	0	0.000	1.061542967006437e-13	0.483	---	455,404,50,0.110	300,300,0,0.000	11.462	15.0
chr9	33797895	33797895	C	T	exonic	PRSS3		nonsynonymous SNV	PRSS3:NM_001197098:exon3:c.C248T:p.A83V,PRSS3:NM_002771:exon3:c.C269T:p.A90V,PRSS3:NM_007343:exon3:c.C440T:p.A147V,PRSS3:NM_001197097:exon4:c.C311T:p.A104V		Score=0.954248;Name=chr9:33612452		0.0005			rs185336947	0.21	0.983708	C	0.29	T	0.0	B	0.990116	N	0.022288	N	2.51	463	126	0.214	380	0	0.000	2.36697321357385926e-30	0.516	---	481,371,110,0.229	309,309,0,0.000	25.944	60
chr9	111617860	111617860	G	A	exonic	ACTL7B		synonymous SNV	ACTL7B:NM_006686:exon1:c.C351T:p.H117H	Score=613;Name=lod=413						rs201253792													172	104	0.377	376	0	0.000	1.61144490325911529e-45	0.519	---	239,146,92,0.387	319,319,0,0.000	39.379	60
chr9	125288840	125288840	C	T	exonic	OR1N1		nonsynonymous SNV	OR1N1:NM_012363:exon1:c.G733A:p.V245I			0.000308		ID=COSM455297;OCCURENCE=1(breast)		rs151154516	0.03	0.954399	C	0.91	T	0.0010	B	0.996893	U	0.066349	N	2.32	73	40	0.354	191	0	0.000	3.54199636416470342e-20	0.450	---	98,59,39,0.398	159,159,0,0.000	18.835	60
chr9	125552152	125552152	G	A	exonic	OR5C1		nonsynonymous SNV	OR5C1:NM_001001923:exon1:c.G941A:p.C314Y								0.33	0.993484	C	1.0	D	0.885	D	0.338391	U	0.408012	NA	2.14	99	24	0.195	194	0	0.000	2.99811468779940839e-11	0.333	---	109,81,27,0.250	157,157,0,0.000	11.473	8.676
chr9	130658547	130658547	G	A	exonic	ST6GALNAC6		nonsynonymous SNV	ST6GALNAC6:NM_013443:exon3:c.C91T:p.R31C	Score=481;Name=lod=120		0.000538				rs146516243	0	0.873535	N	1.0	D	0.887	D	0.038755	N	0.040884	N	-1.1	74	9	0.108	122	0	0.000	0.000222901116424821497	0.556	---	64,58,6,0.094	97,97,0,0.000	2.468	4.591
chr10	71264208	71264208	C	T	exonic	TSPAN15		synonymous SNV	TSPAN15:NM_012339:exon6:c.C585T:p.N195N	Score=491;Name=lod=132																			72	30	0.294	114	0	0.000	1.20148339602607044e-11	0.567	---	83,60,23,0.277	88,88,0,0.000	8.010	60
chr10	75413076	75413076	C	T	exonic	SYNPO2L		nonsynonymous SNV	SYNPO2L:NM_001114133:exon3:c.G593A:p.R198H	Score=452;Name=lod=92							0.02												245	103	0.296	323	0	0.000	8.13429126534799205e-34	0.524	---	276,187,86,0.315	264,264,0,0.000	28.667	60
chr10	82369210	82369210	C	A	exonic	SH2D4B		synonymous SNV	SH2D4B:NM_001145719:exon6:c.C744A:p.V248V,SH2D4B:NM_207372:exon6:c.C888A:p.V296V	Score=325;Name=lod=28																			145	58	0.286	206	0	0.000	1.86680737609207093e-20	0.655	---	162,114,48,0.296	160,160,0,0.000	15.916	60
chr10	83635209	83635209	C	T	exonic	NRG3		nonsynonymous SNV	NRG3:NM_001010848:exon1:c.C113T:p.P38L,NRG3:NM_001165972:exon1:c.C113T:p.P38L	Score=746;Name=lod=1437							0.16	0.815086	N	0.84	T	0.416222	NA	0.807469	NA	0.006458	N	0.374	37	10	0.213	54	0	0.000	0.000269514931919815574	0.800	---	42,33,9,0.214	47,47,0,0.000	3.154	7.4
chr10	135102487	135102487	G	A	exonic	TUBGCP2		synonymous SNV	TUBGCP2:NM_001256618:exon9:c.C1008T:p.D336D,TUBGCP2:NM_006659:exon10:c.C1398T:p.D466D,TUBGCP2:NM_001256617:exon11:c.C1482T:p.D494D			0.000077																	136	17	0.111	200	0	0.000	3.95237136782077806e-07	0.529	---	126,112,14,0.111	169,169,0,0.000	5.362	12.503
chr11	27390500	27390500	A	G	exonic	LGR4		synonymous SNV	LGR4:NM_018490:exon18:c.T1770C:p.Y590Y	Score=553;Name=lod=235																			138	45	0.246	151	0	0.000	1.18782215097555491e-13	0.533	---	147,110,37,0.252	131,131,0,0.000	11.153	60
chr11	49053848	49053848	G	T	exonic	TRIM49B		nonsynonymous SNV	TRIM49B:NM_001206626:exon2:c.G432T:p.M144I		Score=0.965647;Name=chr11:89433919						0.01												142	42	0.228	182	1	0.005	7.98367826096101817e-13	0.690	1.000	160,124,36,0.225	158,157,1,0.006	10.166	9.862
chr11	125490704	125490704	A	G	exonic	STT3A		synonymous SNV	STT3A:NM_152713:exon18:c.A2117G:p.X706X	Score=565;Name=lod=263																			69	47	0.405	109	0	0.000	1.00443297098547631e-16	0.532	---	97,58,38,0.396	82,82,0,0.000	12.026	60
chr11	128839459	128839459	G	A	exonic	ARHGAP32		synonymous SNV	ARHGAP32:NM_014715:exon13:c.C4560T:p.D1520D,ARHGAP32:NM_001142685:exon22:c.C5607T:p.D1869D																				174	79	0.312	253	0	0.000	2.35432474902358112e-27	0.430	---	225,153,71,0.317	223,223,0,0.000	23.948	60
chr12	10569320	10569320	C	T	exonic	KLRC3		nonsynonymous SNV	KLRC3:NM_002261:exon5:c.G533A:p.R178H,KLRC3:NM_007333:exon5:c.G533A:p.R178H		Score=0.974021;Name=chr12:10584672						0.04	0.927894	N	0.98	D	0.568	P	0.979679	N	1.58E-4	N	1.74	168	38	0.184	155	0	0.000	1.35774761982665485e-10	0.526	---	162,133,29,0.179	121,121,0,0.000	7.498	60
chr12	25047362	25047362	T	A	exonic	BCAT1		synonymous SNV	BCAT1:NM_001178092:exon2:c.A54T:p.P18P,BCAT1:NM_001178091:exon3:c.A126T:p.P42P,BCAT1:NM_001178093:exon3:c.A162T:p.P54P,BCAT1:NM_001178094:exon3:c.A123T:p.P41P,BCAT1:NM_005504:exon3:c.A126T:p.P42P	Score=426;Name=lod=72																			102	46	0.311	137	0	0.000	1.50094734656344458e-15	0.326	---	118,82,36,0.305	105,105,0,0.000	11.103	60
chr12	25398284	25398284	C	T	exonic	KRAS		nonsynonymous SNV	KRAS:NM_004985:exon2:c.G35A:p.G12D,KRAS:NM_033360:exon2:c.G35A:p.G12D	Score=706;Name=lod=982				ID=COSM1135366,COSM521;OCCURENCE=1(salivary_gland),248(ovary),8(breast),77(stomach),107(haematopoietic_and_lymphoid_tissue),1(kidney),15(urinary_tract),20(soft_tissue),1970(pancreas),1(peritoneum),10(liver),10(oesophagus),10(gastrointestinal_tract_(site_indeterminate)),12(skin),19(prostate),615(lung),36(thyroid),15(cervix),24(upper_aerodigestive_tract),2(testis),3(eye),5503(large_intestine),1(central_nervous_system),41(small_intestine),266(biliary_tract),148(endometrium)	0.0082	rs121913529	0	0.998873	C	1.0	D	0.657	P	1.0	D	0.999991	D	5.24	123	32	0.206	133	0	0.000	5.63306084550396581e-10	0.375	---	120,96,24,0.200	110,110,0,0.000	7.272	60
chr12	40713842	40713842	C	T	exonic	LRRK2		nonsynonymous SNV	LRRK2:NM_198578:exon34:c.C4880T:p.S1627L	Score=685;Name=lod=811						rs201637880	0.09	0.998812	C	0.93	T	0.125	B	0.995338	N	0.317391	N	4.24	99	20	0.168	140	0	0.000	6.87256372934620612e-08	0.650	---	90,74,16,0.178	107,107,0,0.000	5.787	6.454
chr12	48723385	48723385	C	T	exonic	H1FNT		nonsynonymous SNV	H1FNT:NM_181788:exon1:c.C311T:p.A104V								0.27	0.012676	N	0.96	D	0.036	B	0.563133	NA	0.002388	N	-5.28	227	57	0.201	282	0	0.000	6.16250776248651877e-19	0.456	---	241,188,53,0.220	234,234,0,0.000	16.926	60
chr12	52642474	52642474	C	T	exonic	KRT7		nonsynonymous SNV	KRT7:NM_005556:exon9:c.C1340T:p.A447V								0.22	0.893593	N	0.0	T	0.0020	B	0.846721	NA	0.049613	N	1.47	128	35	0.215	190	0	0.000	1.99904307968098797e-13	0.629	---	133,102,31,0.233	151,151,0,0.000	11.125	9.124
chr12	109865333	109865333	C	G	exonic	MYO1H		nonsynonymous SNV	MYO1H:NM_001101421:exon18:c.C1843G:p.L615V	Score=598;Name=lod=360							0.06												47	24	0.338	106	0	0.000	1.88354206731688151e-11	0.583	---	60,40,20,0.333	87,87,0,0.000	8.750	60
chr12	121014462	121014462	C	G	exonic	RNF10		nonsynonymous SNV	RNF10:NM_014868:exon17:c.C2429G:p.T810S	Score=648;Name=lod=573							0.19	0.999241	C	0.17	T	0.98	D	0.999958	D	0.969029	D	5.62	123	30	0.196	145	0	0.000	5.1803066832960301e-10	0.533	---	125,99,26,0.208	114,114,0,0.000	7.892	60
chr13	49794541	49794541	C	T	exonic	MLNR		nonsynonymous SNV	MLNR:NM_001507:exon1:c.C68T:p.P23L	Score=284;Name=lod=19							0.2	0.13212	N	0.36	T	0.0050	B	0.468276	N	0.004496	N	-0.547	132	16	0.108	154	0	0.000	7.1542508219224699e-06	0.875	---	118,104,14,0.119	132,132,0,0.000	4.752	7.132
chr14	75329400	75329400	G	A	exonic	PROX2		stopgain	PROX2:NM_001243007:exon1:c.C1138T:p.R380X								1												152	38	0.200	194	0	0.000	3.06118103024746914e-13	0.474	---	156,127,29,0.186	160,159,0,0.000	9.479	60
chr15	26026197	26026197	C	T	exonic	ATP10A		nonsynonymous SNV	ATP10A:NM_024490:exon2:c.G623A:p.R208Q	Score=569;Name=lod=275				ID=COSM258926;OCCURENCE=1(large_intestine)			1	0.997954	C	0.16	T	0.056	B	0.999983	D	0.867244	D	3.08	139	33	0.192	186	0	0.000	5.35823446512556834e-12	0.485	---	141,113,28,0.199	151,151,0,0.000	9.520	4.718
chr15	45713240	45713240	G	A	splicing	SPATA5L1	NM_024063:exon8:c.2095-1G>A			Score=500;Name=lod=144																			97	22	0.185	114	0	0.000	1.80696908973734763e-07	0.727	---	94,75,18,0.194	91,91,0,0.000	5.508	5.54
chr15	74468195	74468195	G	T	exonic	ISLR		nonsynonymous SNV	ISLR:NM_005545:exon2:c.G996T:p.E332D,ISLR:NM_201526:exon2:c.G996T:p.E332D	Score=520;Name=lod=173							0.22	0.885983	N	0.59	T	0.235	P	0.994225	U	0.403205	N	1.44	191	62	0.245	269	0	0.000	3.8928607688466247e-22	0.548	---	223,166,57,0.256	234,234,0,0.000	19.589	60
chr15	79586056	79586056	G	C	exonic	ANKRD34C		nonsynonymous SNV	ANKRD34C:NM_001146341:exon2:c.G430C:p.A144P	Score=535;Name=lod=199							0												227	58	0.204	275	0	0.000	4.43981433059508041e-19	0.534	---	250,197,53,0.212	237,237,0,0.000	16.637	60
chr16	2230505	2230505	G	A	exonic	CASKIN1		nonsynonymous SNV	CASKIN1:NM_020764:exon18:c.C2864T:p.S955L	Score=481;Name=lod=120							0.3	0.996801	C	0.952866	NA	0.981	D	1.0	NA	0.984714	D	3.15	237	96	0.288	259	1	0.004	3.99962233524963755e-26	0.479	1.000	285,202,82,0.289	221,220,1,0.005	21.456	60
chr16	70513148	70513148	G	T	exonic	FUK		nonsynonymous SNV	FUK:NM_145059:exon23:c.G2995T:p.G999C	Score=596;Name=lod=353							0	0.999262	C	1.0	D	0.999	D	1.0	D	0.660479	D	4.19	73	36	0.330	119	0	0.000	7.78415213974346972e-14	0.667	---	93,61,32,0.344	96,95,1,0.010	9.938	60
chr17	7577498	7577498	C	T	splicing	TP53	NM_001276761:exon8:c.665+1G>A,NM_001276760:exon8:c.665+1G>A,NM_001276699:exon4:c.305+1G>A,NM_001276698:exon4:c.305+1G>A,NM_001276697:exon4:c.305+1G>A,NM_001126117:exon4:c.386+1G>A,NM_000546:exon8:c.782+1G>A,NM_001126118:exon7:c.665+1G>A,NM_001126115:exon4:c.386+1G>A,NM_001126116:exon4:c.386+1G>A,NM_001126113:exon8:c.782+1G>A,NM_001126112:exon8:c.782+1G>A,NM_001126114:exon8:c.782+1G>A,NM_001276696:exon8:c.665+1G>A,NM_001276695:exon8:c.665+1G>A			Score=440;Name=lod=82				ID=COSM395658,COSM395657,COSM98254,COSM98255,COSM43571;OCCURENCE=1(ovary),3(breast),1(stomach),1(urinary_tract),1(liver),1(oesophagus),1(lung),1(upper_aerodigestive_tract),2(large_intestine),1(biliary_tract)															20	21	0.512	44	0	0.000	6.19324566619094038e-09	0.667	---	33,17,16,0.485	38,38,0,0.000	6.438	15.955
chr17	10360740	10360740	C	T	exonic	MYH4		nonsynonymous SNV	MYH4:NM_017533:exon16:c.G1894A:p.A632T	Score=391;Name=lod=52								0.903402	N	0.68	T	0.0010	B	0.632013	U	0.084864	N	2.42	115	69	0.375	210	0	0.000	3.49111182711678401e-27	0.841	---	162,102,60,0.370	184,182,0,0.000	22.711	60
chr17	34951525	34951525	T	G	exonic	DHRS11		nonsynonymous SNV	DHRS11:NM_024308:exon2:c.T272G:p.V91G	Score=510;Name=lod=158							0	0.998507	C	1.0	D	0.992	D	1.0	D	0.999839	D	5.62	144	18	0.111	190	0	0.000	5.00831508570856084e-07	0.000	---	162,137,25,0.154	148,148,0,0.000	7.427	8.973
chr17	58024066	58024066	C	T	exonic	RPS6KB1		stopgain	RPS6KB1:NM_001272042:exon14:c.C1426T:p.R476X,RPS6KB1:NM_001272060:exon15:c.C1426T:p.R476X,RPS6KB1:NM_003161:exon15:c.C1495T:p.R499X,RPS6KB1:NM_001272044:exon16:c.C1336T:p.R446X	Score=539;Name=lod=207	Score=0.937189;Name=chr17:20616228	0.000077				rs149039467	1	0.915283	N	0.897101	NA	0.721626	NA	0.999997	D	1.0	D	2.74	116	33	0.221	136	0	0.000	7.78812171373454802e-11	0.576	---	133,102,31,0.233	117,117,0,0.000	9.124	12.045
chr18	21776103	21776103	T	C	exonic	OSBPL1A		nonsynonymous SNV	OSBPL1A:NM_018030:exon4:c.A124G:p.K42E,OSBPL1A:NM_001242508:exon6:c.A517G:p.K173E,OSBPL1A:NM_080597:exon18:c.A1663G:p.K555E	Score=631;Name=lod=487							0.01	0.997406	C	0.96	D	0.026	B	1.0	D	0.637162	D	5.03	31	24	0.436	72	0	0.000	5.07541131364567701e-11	0.583	---	42,24,18,0.429	56,56,0,0.000	7.765	15.109
chr19	989795	989795	C	T	exonic	WDR18		stopgain	WDR18:NM_024100:exon3:c.C355T:p.R119X	Score=518;Name=lod=170							1	0.996517	C	0.90359	NA	0.734985	NA	0.99999	D	1.0	A	3.68	117	59	0.335	192	0	0.000	2.80731016761227903e-22	0.610	---	146,99,46,0.317	160,160,0,0.000	16.789	60
chr19	8136998	8136998	G	A	exonic	FBN3		synonymous SNV	FBN3:NM_032447:exon62:c.C8022T:p.Y2674Y	Score=525;Name=lod=181																			95	34	0.264	149	0	0.000	3.1551338532600013e-13	0.471	---	106,76,29,0.276	116,115,0,0.000	10.333	60
chr19	11106955	11106955	T	C	exonic	SMARCA4		synonymous SNV	SMARCA4:NM_001128845:exon9:c.T1660C:p.L554L,SMARCA4:NM_001128846:exon9:c.T1660C:p.L554L,SMARCA4:NM_001128847:exon9:c.T1660C:p.L554L,SMARCA4:NM_001128848:exon9:c.T1660C:p.L554L,SMARCA4:NM_001128849:exon10:c.T1660C:p.L554L,SMARCA4:NM_003072:exon10:c.T1660C:p.L554L,SMARCA4:NM_001128844:exon11:c.T1660C:p.L554L	Score=616;Name=lod=424																			78	33	0.297	100	0	0.000	8.26780529574817867e-11	0.576	---	92,62,30,0.326	82,79,0,0.000	9.136	60
chr19	16860925	16860925	A	G	exonic	NWD1		nonsynonymous SNV	NWD1:NM_001007525:exon6:c.A1472G:p.E491G	Score=423;Name=lod=70							0.01	0.997143	C	0.99	D	0.973	D	0.999999	D	0.610822	D	4.5	106	23	0.178	132	0	0.000	3.078626109639601e-08	0.609	---	115,95,20,0.174	112,111,0,0.000	6.090	8.833
chr19	54410051	54410051	G	A	exonic	PRKCG		nonsynonymous SNV	PRKCG:NM_002739:exon18:c.G1996A:p.D666N	Score=436;Name=lod=79		0.000077					0.06	0.999197	C	0.97	D	0.013	B	0.863739	NA	0.225617	N	4.33	128	77	0.376	232	0	0.000	4.21960416245787259e-30	0.610	---	164,105,59,0.360	182,182,0,0.000	22.043	60
chr19	55870794	55870794	T	C	exonic	FAM71E2		nonsynonymous SNV	FAM71E2:NM_001145402:exon9:c.A1442G:p.K481R								0.07												231	119	0.340	300	0	0.000	1.98715523710138245e-37	0.496	---	284,191,92,0.325	242,240,0,0.000	27.990	12.68
chr20	21689899	21689899	G	A	exonic	PAX1		nonsynonymous SNV	PAX1:NM_001257096:exon4:c.G1099A:p.A367T,PAX1:NM_006192:exon4:c.G1099A:p.A367T	Score=539;Name=lod=206							0	0.99956	C	1.0	D	0.201	P	0.999999	D	0.604487	NA	5.12	182	36	0.165	122	0	0.000	4.4433813260506544e-08	0.722	---	189,157,32,0.169	108,108,0,0.000	6.634	10.214
chr20	44035122	44035122	G	A	exonic	DBNDD2		nonsynonymous SNV	DBNDD2:NM_018478:exon1:c.G31A:p.E11K								0												191	39	0.170	167	0	0.000	2.26702752424350837e-10	0.667	---	186,154,32,0.172	145,145,0,0.000	8.489	60
chr20	46288185	46288185	C	T	exonic	SULF2		nonsynonymous SNV	SULF2:NM_001161841:exon20:c.G2540A:p.R847H,SULF2:NM_018837:exon20:c.G2540A:p.R847H,SULF2:NM_198596:exon20:c.G2531A:p.R844H	Score=627;Name=lod=471		0.000077				rs139043540	0.05	0.999392	C	0.93	T	0.118	B	1.0	D	0.99604	D	5.82	92	18	0.164	85	0	0.000	2.04008085272943448e-05	0.500	---	95,81,14,0.147	68,68,0,0.000	3.409	12.642
chr21	28337777	28337777	G	A	exonic	ADAMTS5		nonsynonymous SNV	ADAMTS5:NM_007038:exon1:c.C934T:p.R312C	Score=698;Name=lod=916								0.999464	C	0.97	D	1.0	D	1.0	D	0.999685	D	4.44	234	92	0.282	329	0	0.000	7.07459520518666566e-32	0.478	---	283,200,83,0.293	286,284,0,0.000	28.126	60
chr21	28338441	28338441	G	A	exonic	ADAMTS5		synonymous SNV	ADAMTS5:NM_007038:exon1:c.C270T:p.L90L	Score=591;Name=lod=337																			292	138	0.321	418	0	0.000	4.59929136473911978e-47	0.558	---	376,258,117,0.312	360,360,0,0.000	38.584	60
chr21	43243714	43243714	C	T	exonic	PRDM15		nonsynonymous SNV	PRDM15:NM_001040424:exon14:c.G1832A:p.R611H,PRDM15:NM_022115:exon21:c.G2819A:p.R940H	Score=523;Name=lod=178							0.05	0.998645	C	0.9	T	0.994	D	1.0	NA	0.999819	D	5.08	116	32	0.216	180	0	0.000	1.11657559658329381e-12	0.469	---	121,93,27,0.225	142,142,0,0.000	9.929	11.483
chr22	17488914	17488914	C	T	exonic	GAB4		nonsynonymous SNV	GAB4:NM_001037814:exon1:c.G91A:p.A31T								0.01	0.109388	N	0.740231	NA	0.345	P	0.613614	NA	1.49E-4	N	-0.832	121	57	0.320	173	0	0.000	8.94751916404973432e-20	0.509	---	145,99,45,0.312	139,139,0,0.000	14.890	60
chr22	29682958	29682958	C	T	exonic	EWSR1		stopgain	EWSR1:NM_001163286:exon6:c.C460T:p.Q154X,EWSR1:NM_001163285:exon7:c.C628T:p.Q210X,EWSR1:NM_001163287:exon7:c.C628T:p.Q210X,EWSR1:NM_005243:exon7:c.C628T:p.Q210X,EWSR1:NM_013986:exon8:c.C646T:p.Q216X	Score=693;Name=lod=872							0	0.998896	C	0.90379	NA	0.735269	NA	0.999381	U	1.0	A	5.27	98	28	0.222	119	0	0.000	1.84781913877022663e-09	0.714	---	112,86,25,0.225	100,100,0,0.000	7.580	12.517
chr22	40082269	40082269	C	T	exonic	CACNA1I		synonymous SNV	CACNA1I:NM_001003406:exon36:c.C6426T:p.S2142S,CACNA1I:NM_021096:exon37:c.C6531T:p.S2177S	Score=278;Name=lod=18																			74	22	0.229	137	0	0.000	6.90950161127152577e-10	0.545	---	84,64,20,0.238	119,119,0,0.000	8.313	6.09
chrX	100747759	100747759	C	T	exonic	ARMCX4		stopgain	ARMCX4:NM_001256155:exon2:c.C4183T:p.Q1395X																				100	37	0.270	129	0	0.000	1.51872080550174039e-12	0.486	---	121,88,33,0.273	114,113,0,0.000	10.486	15.256
chrX	102339273	102339273	G	T	exonic	NXF3		synonymous SNV	NXF3:NM_022052:exon3:c.C348A:p.I116I	Score=304;Name=lod=23																			95	25	0.208	82	0	0.000	9.67352446889126107e-07	0.680	---	96,74,22,0.229	63,63,0,0.000	5.161	9.032