Chr	Start	End	Ref	Alt	Func.refGene	Gene.refGene	GeneDetail.refGene	ExonicFunc.refGene	AAChange.refGene	phastConsElements46way	genomicSuperDups	esp6500si_all	1000g2012apr_all	cosmic65	nci60	snp137	avsift	LJB_PhyloP	LJB_PhyloP_Pred	LJB_SIFT	LJB_SIFT_Pred	LJB_PolyPhen2	LJB_PolyPhen2_Pred	LJB_LRT	LJB_LRT_Pred	LJB_MutationTaster	LJB_MutationTaster_Pred	LJB_GERP++	tumor_ref	tumor_var	misRate_tumor	normal_ref	normal_var	misRate_normal	p-value(Fisher)	strandRatio_tumor	strandRatio_normal	tumor_realign(total,ref,alt,freq)	normal_realign(total,ref,alt,freq)	p-value(Realaign)	p-value(EBcall)
chr1	6662482	6662482	C	T	exonic	KLHL21		synonymous SNV	KLHL21:NM_014851:exon1:c.G396A:p.Q132Q	Score=867;Name=lod=4433																			182	70	0.278	205	0	0.000	6.99079257174747477e-21	0.471	---	212,148,63,0.299	179,179,0,0.000	18.723	60
chr1	16918424	16918424	G	C	exonic	NBPF1		unknown	UNKNOWN		Score=0.969089;Name=chr1:16905978	0.040141				rs9730077	1												25	9	0.265	31	0	0.000	0.00227146429563767713	0.889	---	32,24,8,0.250	32,31,1,0.031	1.577	3.69
chr1	27105921	27105921	G	A	exonic	ARID1A		stopgain	ARID1A:NM_006015:exon20:c.G5532A:p.W1844X,ARID1A:NM_139135:exon20:c.G4881A:p.W1627X	Score=652;Name=lod=593				ID=COSM674181;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)			0	0.999561	C	0.903833	NA	0.735488	NA	1.0	D	1.0	D	4.61	104	118	0.532	276	0	0.000	2.10001116856631078e-52	0.508	---	187,89,98,0.524	244,244,0,0.000	44.042	60
chr1	32740922	32740922	G	A	exonic	LCK		synonymous SNV	LCK:NM_001042771:exon5:c.G279A:p.Q93Q,LCK:NM_005356:exon5:c.G279A:p.Q93Q	Score=321;Name=lod=27																			18	20	0.526	80	0	0.000	1.64392602138756014e-12	0.750	---	35,17,18,0.514	64,64,0,0.000	9.744	60
chr1	109811586	109811586	C	T	exonic	CELSR2		nonsynonymous SNV	CELSR2:NM_001408:exon19:c.C6587T:p.P2196L								0.42	0.997935	C	0.58	T	0.0030	B	0.910255	NA	0.449521	N	4.16	214	93	0.303	230	0	0.000	2.55405016300098716e-26	0.484	---	257,178,79,0.307	199,199,0,0.000	22.254	60
chr1	114196600	114196600	C	G	exonic	MAGI3		synonymous SNV	MAGI3:NM_001142782:exon15:c.C2589G:p.G863G,MAGI3:NM_152900:exon15:c.C2589G:p.G863G	Score=573;Name=lod=283																			109	33	0.232	155	0	0.000	2.96497206542133158e-12	0.364	---	119,89,29,0.246	131,131,0,0.000	10.300	14.239
chr1	177226479	177226479	C	T	exonic	FAM5B		stopgain	FAM5B:NM_021165:exon4:c.C628T:p.R210X	Score=333;Name=lod=30							1	0.903845	N	0.896187	NA	0.719746	NA	1.0	D	1.0	A	2.15	134	69	0.340	161	0	0.000	1.18979889280680428e-20	0.449	---	166,107,58,0.352	131,131,0,0.000	16.939	60
chr1	196342357	196342357	T	A	exonic	KCNT2		nonsynonymous SNV	KCNT2:NM_198503:exon14:c.A1316T:p.E439V	Score=688;Name=lod=831							0	0.998164	C	1.0	D	0.842	P	0.999998	D	0.999995	D	5.39	36	17	0.321	46	0	0.000	6.17044789173969779e-06	0.294	---	43,29,14,0.326	37,37,0,0.000	4.252	9.682
chr2	20647739	20647739	C	A	exonic	RHOB		nonsynonymous SNV	RHOB:NM_004040:exon1:c.C513A:p.F171L	Score=708;Name=lod=1009							0	0.234947	N	1.0	D	1.0	D	1.0	U	0.999922	D	-1.77	212	30	0.124	177	0	0.000	5.4565294955595681e-08	0.500	---	194,171,23,0.119	145,145,0,0.000	5.657	13.626
chr2	131520725	131520725	C	T	exonic	AMER3		synonymous SNV	AMER3:NM_001105193:exon2:c.C1080T:p.S360S,AMER3:NM_001105194:exon2:c.C1080T:p.S360S,AMER3:NM_001105195:exon2:c.C1080T:p.S360S,AMER3:NM_152698:exon2:c.C1080T:p.S360S																				235	114	0.327	313	0	0.000	7.14437480570523728e-37	0.535	---	298,203,95,0.319	251,251,0,0.000	28.751	60
chr2	168115543	168115543	G	T	exonic	XIRP2		nonsynonymous SNV	XIRP2:NM_001199145:exon8:c.G1821T:p.K607N,XIRP2:NM_001079810:exon10:c.G2487T:p.K829N,XIRP2:NM_001199143:exon11:c.G2586T:p.K862N								0.64	0.077085	N	0.712775	NA	0.216892	NA	0.599349	NA	4.89E-4	N	-0.276	132	62	0.320	192	0	0.000	1.32459042324256842e-21	0.387	---	162,110,52,0.321	169,169,0,0.000	18.304	60
chr2	179605032	179605032	G	T	exonic	TTN		nonsynonymous SNV	TTN:NM_003319:exon45:c.C11839A:p.P3947T,TTN:NM_001256850:exon46:c.C11977A:p.P3993T,TTN:NM_133432:exon46:c.C12214A:p.P4072T,TTN:NM_133437:exon46:c.C12415A:p.P4139T,TTN:NM_001267550:exon48:c.C12928A:p.P4310T																				173	84	0.327	219	0	0.000	1.81652979964297193e-26	0.476	---	229,155,74,0.323	195,195,0,0.000	22.559	60
chr2	179635189	179635189	T	A	exonic	TTN		nonsynonymous SNV	TTN:NM_003319:exon34:c.A8192T:p.Y2731F,TTN:NM_133432:exon34:c.A8192T:p.Y2731F,TTN:NM_133437:exon34:c.A8192T:p.Y2731F,TTN:NM_001256850:exon35:c.A8330T:p.Y2777F,TTN:NM_001267550:exon35:c.A8330T:p.Y2777F,TTN:NM_133378:exon35:c.A8330T:p.Y2777F,TTN:NM_133379:exon35:c.A8330T:p.Y2777F	Score=527;Name=lod=185							0	0.998333	C	0.900874	NA	0.730813	NA	1.0	NA	0.978342	D	5.51	175	60	0.255	242	0	0.000	4.44159643358094733e-21	0.500	---	205,152,52,0.255	219,218,0,0.000	18.088	60
chr2	201721423	201721423	C	T	exonic	CLK1		nonsynonymous SNV	CLK1:NM_001162407:exon9:c.G1165A:p.A389T,CLK1:NM_004071:exon9:c.G1039A:p.A347T	Score=536;Name=lod=202							0	0.998321	C	1.0	D	0.033	B	1.0	D	0.995646	D	4.88	57	40	0.412	75	0	0.000	1.46764551875949369e-12	0.675	---	82,50,32,0.390	65,65,0,0.000	9.508	9.26
chr2	242573220	242573220	C	T	exonic	THAP4		nonsynonymous SNV	THAP4:NM_015963:exon2:c.G352A:p.A118T									0.123302	N	0.92	T	0.0	B	0.075686	N	0.009352	N	-1.24	121	69	0.363	152	0	0.000	2.85268053834091271e-21	0.464	---	157,100,57,0.363	140,140,0,0.000	18.338	60
chr3	38592077	38592077	C	T	exonic	SCN5A		nonsynonymous SNV	SCN5A:NM_001099405:exon27:c.G5732A:p.R1911H,SCN5A:NM_001160161:exon27:c.G5624A:p.R1875H,SCN5A:NM_000335:exon28:c.G5783A:p.R1928H,SCN5A:NM_001099404:exon28:c.G5786A:p.R1929H,SCN5A:NM_001160160:exon28:c.G5687A:p.R1896H,SCN5A:NM_198056:exon28:c.G5786A:p.R1929H	Score=505;Name=lod=150				ID=COSM241530;OCCURENCE=1(prostate),1(large_intestine)			0.06												172	75	0.304	233	0	0.000	5.77495726446153247e-25	0.520	---	209,144,65,0.311	199,199,0,0.000	21.385	60
chr3	51312619	51312619	C	A	exonic	DOCK3		synonymous SNV	DOCK3:NM_004947:exon25:c.C2658A:p.I886I	Score=571;Name=lod=280																			139	43	0.236	171	0	0.000	2.89541792763682187e-14	0.512	---	142,106,36,0.254	136,135,0,0.000	11.475	12.827
chr3	58296274	58296274	T	G	exonic	RPP14		nonsynonymous SNV	RPP14:NM_001098783:exon3:c.T118G:p.F40V,RPP14:NM_007042:exon3:c.T118G:p.F40V	Score=445;Name=lod=86							0.01	0.997683	C	0.96	D	0.967	D	1.0	D	0.961297	D	5.15	73	35	0.324	77	0	0.000	6.70957721585243816e-10	0.343	---	91,58,33,0.363	69,68,1,0.014	8.082	60
chr3	89457243	89457243	G	T	exonic	EPHA3		nonsynonymous SNV	EPHA3:NM_005233:exon9:c.G1724T:p.G575V	Score=512;Name=lod=160							0.38	0.999743	C	0.73	T	0.0080	B	0.995733	N	0.235983	N	4.48	86	30	0.259	103	0	0.000	1.20954066117758779e-09	0.567	---	90,65,25,0.278	85,85,0,0.000	7.964	11.868
chr3	113658770	113658770	C	A	exonic	GRAMD1C		nonsynonymous SNV	GRAMD1C:NM_001172105:exon11:c.C1114A:p.L372M,GRAMD1C:NM_017577:exon16:c.C1729A:p.L577M	Score=531;Name=lod=192							0.01	0.129709	N	0.85	T	0.014	B	0.991728	N	0.52266	D	0.59	35	18	0.340	66	0	0.000	6.99526289583814837e-08	0.444	---	37,25,12,0.324	52,52,0,0.000	5.108	60
chr3	170185068	170185068	G	A	exonic	SLC7A14		synonymous SNV	SLC7A14:NM_020949:exon8:c.C2091T:p.D697D	Score=545;Name=lod=219																			141	80	0.362	180	0	0.000	1.31793005426174629e-24	0.400	---	182,116,66,0.363	156,156,0,0.000	20.381	60
chr3	186953629	186953629	C	T	exonic	MASP1		nonsynonymous SNV	MASP1:NM_139125:exon11:c.G2030A:p.R677H	Score=546;Name=lod=221							0.2	0.009908	N	0.807609	NA	0.504159	NA	0.872039	N	0.844764	D	-6.91	109	82	0.429	192	0	0.000	2.24202321225415086e-30	0.451	---	167,97,68,0.412	167,166,0,0.000	24.381	60
chr4	898515	898515	G	A	exonic	GAK		synonymous SNV	GAK:NM_005255:exon5:c.C435T:p.C145C																				69	40	0.367	97	0	0.000	1.64730312558345042e-13	0.375	---	95,59,35,0.372	83,83,0,0.000	11.114	12.598
chr4	55970872	55970872	C	G	exonic	KDR		nonsynonymous SNV	KDR:NM_002253:exon13:c.G1925C:p.C642S	Score=552;Name=lod=233							0	0.999252	C	1.0	D	0.999	D	1.0	D	0.99998	D	5.64	87	54	0.383	115	0	0.000	3.96311323845620275e-17	0.537	---	124,76,48,0.387	99,99,0,0.000	14.377	60
chr4	57181594	57181594	C	T	exonic	KIAA1211		synonymous SNV	KIAA1211:NM_020722:exon8:c.C1926T:p.P642P																				149	69	0.317	222	0	0.000	1.38943608399438861e-24	0.507	---	192,128,63,0.330	181,181,0,0.000	20.837	60
chr4	189013022	189013022	C	A	exonic	TRIML2		nonsynonymous SNV	TRIML2:NM_173553:exon7:c.G669T:p.L223F								0.58	0.040176	N	0.25	T	0.0	B	0.593362	N	0.009903	N	-5.67	142	40	0.220	175	0	0.000	2.17566266721372234e-13	0.425	---	145,114,31,0.214	138,137,1,0.007	8.435	60
chr4	189061004	189061004	A	G	exonic	TRIML1		nonsynonymous SNV	TRIML1:NM_178556:exon1:c.A292G:p.M98V								0.47	0.215263	N	0.18	T	0.364	P	0.969697	N	0.113768	N	-0.00348	125	64	0.339	156	0	0.000	5.66640565831325943e-20	0.516	---	146,95,51,0.349	129,129,0,0.000	16.185	60
chr5	82833683	82833683	G	T	exonic	VCAN		stopgain	VCAN:NM_001164097:exon7:c.G1900T:p.E634X,VCAN:NM_004385:exon8:c.G4861T:p.E1621X								0	0.992856	C	0.905019	NA	0.715572	NA	0.89324	N	1.0	A	3.46	164	80	0.328	255	0	0.000	4.92607620410961319e-29	0.562	---	198,134,64,0.323	221,221,0,0.000	23.620	60
chr5	112128143	112128143	C	T	exonic	APC		stopgain	APC:NM_000038:exon7:c.C646T:p.R216X,APC:NM_001127510:exon8:c.C646T:p.R216X	Score=606;Name=lod=387				ID=COSM98420;OCCURENCE=12(large_intestine)		rs62619935	0.32	0.977717	C	0.903962	NA	0.711419	NA	0.883806	N	1.0	A	3.07	49	29	0.372	72	0	0.000	2.78108819940822198e-10	0.552	---	58,37,21,0.362	60,60,0,0.000	7.455	12.367
chr5	112162804	112162804	G	A	splicing	APC	NM_001127511:exon10:c.1355-1G>A,NM_000038:exon12:c.1409-1G>A,NM_001127510:exon13:c.1409-1G>A			Score=489;Name=lod=130				ID=COSM1432173;OCCURENCE=1(large_intestine)															63	36	0.364	95	0	0.000	7.60186186303666715e-13	0.722	---	87,58,28,0.326	79,79,0,0.000	8.997	60
chr5	134332105	134332105	G	A	exonic	CATSPER3		nonsynonymous SNV	CATSPER3:NM_178019:exon3:c.G395A:p.R132H								0.08	0.877828	N	0.87	T	0.999	D	0.955769	N	0.639199	D	0.333	81	40	0.331	129	0	0.000	4.57048929034144845e-15	0.425	---	109,72,37,0.339	112,112,0,0.000	12.983	60
chr5	140256977	140256977	G	A	exonic	PCDHA12		synonymous SNV	PCDHA12:NM_018903:exon1:c.G1920A:p.A640A,PCDHA12:NM_031864:exon1:c.G1920A:p.A640A																				365	148	0.288	458	0	0.000	9.66384160693525685e-47	0.459	---	441,316,125,0.283	393,392,0,0.000	38.725	60
chr5	140731370	140731370	G	A	exonic	PCDHGB1		nonsynonymous SNV	PCDHGB1:NM_018922:exon1:c.G1543A:p.A515T,PCDHGB1:NM_032095:exon1:c.G1543A:p.A515T	Score=517;Name=lod=168																			352	178	0.336	466	4	0.009	3.25408548028760563e-50	0.590	0.500	450,304,144,0.321	387,385,2,0.005	40.936	60
chr5	141334539	141334539	G	T	exonic	PCDH12		nonsynonymous SNV	PCDH12:NM_016580:exon1:c.C2878A:p.Q960K	Score=407;Name=lod=60							0.02	0.999125	C	0.92	T	0.997	D	1.0	D	0.796437	D	4.08	122	46	0.274	148	0	0.000	8.94213001640010367e-15	0.652	---	138,97,41,0.297	125,125,0,0.000	12.746	14.654
chr5	159520124	159520124	G	A	exonic	PWWP2A		synonymous SNV	PWWP2A:NM_001130864:exon2:c.C1533T:p.T511T,PWWP2A:NM_001267035:exon2:c.C1533T:p.T511T,PWWP2A:NM_052927:exon2:c.C1533T:p.T511T	Score=651;Name=lod=589																			128	54	0.297	148	0	0.000	2.09240713634573304e-16	0.500	---	159,111,48,0.302	128,128,0,0.000	13.795	60
chr5	176707570	176707570	A	G	exonic	NSD1		nonsynonymous SNV	NSD1:NM_022455:exon18:c.A5627G:p.N1876S,NSD1:NM_172349:exon19:c.A4820G:p.N1607S	Score=455;Name=lod=94							0.01	0.998812	C	1.0	D	0.995	D	0.999998	D	0.269218	N	5.33	59	30	0.337	89	0	0.000	9.76044620067858575e-11	0.733	---	81,52,29,0.358	80,80,0,0.000	9.760	60
chr6	15497044	15497044	C	A	exonic	JARID2		nonsynonymous SNV	JARID2:NM_001267040:exon7:c.C1072A:p.P358T,JARID2:NM_004973:exon7:c.C1588A:p.P530T	Score=541;Name=lod=211							1	0.220277	N	0.81	T	0.0	B	0.935084	N	0.657737	D	-1.04	111	46	0.293	138	0	0.000	7.04039051905575266e-15	0.565	---	134,93,39,0.295	120,120,0,0.000	12.076	15.477
chr6	30552108	30552108	G	T	exonic	ABCF1		nonsynonymous SNV	ABCF1:NM_001090:exon12:c.G1128T:p.K376N,ABCF1:NM_001025091:exon13:c.G1242T:p.K414N	Score=429;Name=lod=74							0.02	0.999123	C	0.89	T	0.475	P	1.0	D	0.649887	NA	4.08	186	106	0.363	235	0	0.000	3.34458209658443476e-32	0.453	---	259,163,96,0.371	201,201,0,0.000	28.080	60
chr6	41162479	41162479	G	A	exonic	TREML2		nonsynonymous SNV	TREML2:NM_024807:exon3:c.C469T:p.P157S								0.02	0.215263	N	1.0	D	0.426795	NA	0.532847	N	0.200878	N	-3.41	150	70	0.318	157	0	0.000	1.82303209046436083e-19	0.414	---	174,121,53,0.305	130,130,0,0.000	14.350	60
chr6	128134283	128134283	G	A	exonic	THEMIS		synonymous SNV	THEMIS:NM_001010923:exon4:c.C1503T:p.C501C,THEMIS:NM_001164685:exon4:c.C1503T:p.C501C,THEMIS:NM_001164687:exon4:c.C1398T:p.C466C	Score=439;Name=lod=81																			159	71	0.309	214	0	0.000	1.32264343934982232e-23	0.662	---	197,131,66,0.335	187,186,0,0.000	21.830	60
chr6	151748624	151748624	T	C	exonic	RMND1		nonsynonymous SNV	RMND1:NM_001271937:exon5:c.A313G:p.K105E,RMND1:NM_017909:exon6:c.A823G:p.K275E	Score=395;Name=lod=54							0.27	0.970217	C	0.0	T	0.871	D	0.991997	N	0.006236	N	4.01	51	13	0.203	41	0	0.000	0.00143459621206532919	0.462	---	50,37,12,0.245	32,32,0,0.000	2.607	9.988
chr7	2582845	2582845	C	T	exonic	BRAT1		nonsynonymous SNV	BRAT1:NM_152743:exon6:c.G916A:p.E306K			0.000077					0.41	0.990385	C	0.97	D	0.59898	NA	0.921493	N	0.306228	N	2.59	192	46	0.193	163	0	0.000	5.84223292695779268e-12	0.674	---	207,164,43,0.208	140,140,0,0.000	10.448	12.069
chr7	17937007	17937007	T	C	exonic	SNX13		synonymous SNV	SNX13:NM_015132:exon2:c.A75G:p.G25G	Score=686;Name=lod=818																			65	50	0.435	91	0	0.000	4.93349678155626874e-16	0.420	---	87,51,36,0.414	71,71,0,0.000	11.054	60
chr8	110397822	110397822	G	T	exonic	PKHD1L1		nonsynonymous SNV	PKHD1L1:NM_177531:exon6:c.G532T:p.A178S	Score=596;Name=lod=353							0.1												71	24	0.253	86	0	0.000	4.16636739146114821e-08	0.458	---	75,57,18,0.240	68,66,2,0.029	3.674	11.238
chr9	21187146	21187146	C	T	exonic	IFNA4		nonsynonymous SNV	IFNA4:NM_021068:exon1:c.G385A:p.V129M		Score=0.942811;Name=chr9:21186709,chr9:21165785			ID=COSM1107790;OCCURENCE=1(endometrium)		rs1062573	0.08	8.1E-5	N	0.89	T	0.0	B	0.11263	N	0.0	NA	-5.34	218	70	0.243	312	0	0.000	3.39218437713141721e-25	0.329	---	254,183,71,0.280	268,268,0,0.000	24.752	60
chr9	21187179	21187179	C	T	exonic	IFNA4		nonsynonymous SNV	IFNA4:NM_021068:exon1:c.G352A:p.D118N		Score=0.942811;Name=chr9:21165785,chr9:21186709			ID=COSM1107791;OCCURENCE=1(endometrium)		rs1062572	0.03	0.989286	C	0.99	D	0.0050	B	0.532622	N	0.303798	NA	1.46	194	66	0.254	278	0	0.000	1.08248436937642692e-23	0.470	---	245,178,67,0.273	255,255,0,0.000	23.077	60
chr9	32542476	32542476	G	A	exonic	TOPORS		nonsynonymous SNV	TOPORS:NM_001195622:exon2:c.C1852T:p.R618W,TOPORS:NM_005802:exon3:c.C2047T:p.R683W	Score=573;Name=lod=284		0.000154				rs143249653	0	0.999823	C	1.0	D	0.573802	NA	0.92416	N	0.114805	N	4.67	101	40	0.284	139	0	0.000	7.38299207001788032e-14	0.525	---	123,88,35,0.285	129,129,0,0.000	12.157	60
chr10	38345115	38345115	C	T	exonic	ZNF33A		nonsynonymous SNV	ZNF33A:NM_006954:exon5:c.C2063T:p.T688M,ZNF33A:NM_006974:exon5:c.C2060T:p.T687M	Score=473;Name=lod=112	Score=0.928956;Name=chr10:43037558	0.000154				rs146461823	0.04	0.958507	C	0.9	T	0.983	D	0.997274	N	0.395742	N	1.57	149	61	0.290	242	0	0.000	2.10288304335430806e-23	0.459	---	183,129,53,0.291	206,206,0,0.000	19.467	60
chr10	55996637	55996637	G	A	exonic	PCDH15		nonsynonymous SNV	PCDH15:NM_001142767:exon8:c.C820T:p.R274W,PCDH15:NM_001142768:exon8:c.C865T:p.R289W,PCDH15:NM_001142773:exon8:c.C865T:p.R289W,PCDH15:NM_001142764:exon9:c.C931T:p.R311W,PCDH15:NM_001142765:exon9:c.C931T:p.R311W,PCDH15:NM_001142766:exon9:c.C931T:p.R311W,PCDH15:NM_033056:exon9:c.C931T:p.R311W,PCDH15:NM_001142763:exon10:c.C946T:p.R316W	Score=596;Name=lod=352				ID=COSM313924,COSM313922,COSM313923;OCCURENCE=1(lung)			0	0.985513	C	1.0	D	0.999	D	1.0	NA	0.999991	D	3.5	80	53	0.398	123	0	0.000	2.34525026580525732e-18	0.491	---	106,66,40,0.377	96,96,0,0.000	12.916	60
chr11	5221636	5221636	G	A	exonic	OR51V1		stopgain	OR51V1:NM_001004760:exon1:c.C295T:p.R99X								1	0.160313	N	0.846101	NA	0.495738	NA	0.422754	N	1.0	D	-3.32	99	39	0.283	126	0	0.000	9.97783893871642034e-13	0.513	---	116,85,31,0.267	103,103,0,0.000	9.281	60
chr11	6245177	6245177	C	T	exonic	FAM160A2		nonsynonymous SNV	FAM160A2:NM_001098794:exon3:c.G440A:p.R147Q,FAM160A2:NM_032127:exon3:c.G440A:p.R147Q	Score=653;Name=lod=600							0.3	0.979584	C	0.68	T	0.027	B	0.998798	N	0.416314	N	2.11	235	106	0.311	258	0	0.000	3.63594553844654105e-30	0.538	---	289,198,91,0.315	221,221,0,0.000	25.602	60
chr11	48164526	48164526	A	G	exonic	PTPRJ		synonymous SNV	PTPRJ:NM_002843:exon12:c.A2499G:p.V833V																				111	52	0.319	97	0	0.000	7.83066336580126875e-13	0.558	---	134,89,44,0.331	84,84,0,0.000	10.680	60
chr11	62549651	62549651	C	T	exonic	TAF6L		nonsynonymous SNV	TAF6L:NM_006473:exon8:c.C673T:p.R225C	Score=671;Name=lod=714				ID=COSM293163;OCCURENCE=1(large_intestine)			0.03	0.934087	N	0.88	T	0.976	D	0.999602	D	0.868783	D	2.66	137	64	0.318	153	0	0.000	1.14406185539444248e-18	0.547	---	167,112,55,0.329	130,130,0,0.000	15.704	60
chr11	67222946	67222946	C	T	exonic	CABP4		nonsynonymous SNV	CABP4:NM_145200:exon1:c.C52T:p.R18C								0.02	0.229599	N	1.0	D	0.0010	B	1.0E-4	N	7.6E-5	N	-0.54	147	32	0.179	157	0	0.000	6.17130194399518669e-10	0.531	---	146,121,24,0.166	129,129,0,0.000	7.038	11.059
chr13	53420687	53420687	T	C	exonic	PCDH8		nonsynonymous SNV	PCDH8:NM_002590:exon1:c.A1885G:p.K629E,PCDH8:NM_032949:exon1:c.A1885G:p.K629E								0.13	0.074297	N	0.2	T	0.0040	B	0.654543	N	0.082441	N	3.0	416	74	0.151	199	0	0.000	3.46604523120657181e-12	0.392	---	432,364,65,0.152	172,172,0,0.000	10.038	14.122
chr13	103401347	103401347	G	A	exonic	CCDC168		nonsynonymous SNV	CCDC168:NM_001146197:exon4:c.C1700T:p.P567L				0.01			rs116890855													257	50	0.163	139	0	0.000	4.06227412866836565e-09	0.320	---	254,210,44,0.173	109,108,0,0.000	7.157	15.0
chr14	20781954	20781954	G	A	exonic	CCNB1IP1		stopgain	CCNB1IP1:NM_182849:exon5:c.C304T:p.Q102X,CCNB1IP1:NM_021178:exon6:c.C304T:p.Q102X,CCNB1IP1:NM_182852:exon7:c.C304T:p.Q102X	Score=655;Name=lod=611							0	0.992415	C	0.903262	NA	0.734312	NA	1.0	D	1.0	A	4.35	44	30	0.405	111	0	0.000	1.44559580923375825e-14	0.333	---	61,36,25,0.410	90,89,0,0.000	11.347	13.195
chr14	44975756	44975756	G	A	exonic	FSCB		synonymous SNV	FSCB:NM_032135:exon1:c.C435T:p.I145I																				39	62	0.614	147	0	0.000	6.82288238730183373e-32	0.484	---	83,32,51,0.614	123,123,0,0.000	25.892	60
chr15	23892013	23892013	C	A	exonic	MAGEL2		nonsynonymous SNV	MAGEL2:NM_019066:exon1:c.G877T:p.G293C	Score=243;Name=lod=13																			112	217	0.660	322	0	0.000	8.68881796655252684e-89	0.622	---	299,97,201,0.674	288,288,0,0.000	60.000	60
chr15	41829301	41829301	C	G	exonic	RPAP1		nonsynonymous SNV	RPAP1:NM_015540:exon2:c.G23C:p.G8A	Score=431;Name=lod=75							0.06	0.999007	C	0.77	T	0.325	P	0.999262	N	0.979471	D	4.28	36	84	0.700	102	0	0.000	1.13050161466388493e-32	0.310	---	103,28,75,0.728	88,87,0,0.000	28.991	60
chr15	49089578	49089578	T	C	exonic	CEP152		nonsynonymous SNV	CEP152:NM_001194998:exon5:c.A460G:p.T154A,CEP152:NM_014985:exon5:c.A460G:p.T154A								0.11	0.859728	N	0.9	T	0.049	B	0.976258	N	0.050199	N	1.47	42	97	0.698	123	0	0.000	2.60264604168093185e-38	0.515	---	110,31,79,0.718	105,104,0,0.000	32.571	60
chr16	23224037	23224037	G	T	exonic	SCNN1G		stopgain	SCNN1G:NM_001039:exon9:c.G1333T:p.E445X	Score=452;Name=lod=92							0.04	0.999517	C	0.90383	NA	0.73548	NA	1.0	D	1.0	A	5.06	56	30	0.349	70	0	0.000	1.9725135326349035e-09	0.633	---	70,45,25,0.357	60,60,0,0.000	7.630	15.955
chr16	58608624	58608624	C	T	exonic	CNOT1		nonsynonymous SNV	CNOT1:NM_001265612:exon16:c.G1868A:p.R623Q,CNOT1:NM_016284:exon16:c.G1868A:p.R623Q,CNOT1:NM_206999:exon16:c.G1868A:p.R623Q	Score=700;Name=lod=930							0	0.997802	C	0.99	D	1.0	D	1.0	D	0.999944	D	4.63	179	105	0.370	272	0	0.000	3.27388066739532877e-36	0.457	---	226,142,84,0.372	227,224,0,0.000	29.108	60
chr16	70691024	70691024	G	A	exonic	IL34		synonymous SNV	IL34:NM_001172771:exon5:c.G399A:p.T133T,IL34:NM_001172772:exon5:c.G402A:p.T134T,IL34:NM_152456:exon5:c.G402A:p.T134T	Score=304;Name=lod=23		0.000077																	74	35	0.321	90	0	0.000	5.84668550879941547e-11	0.400	---	92,64,28,0.304	80,80,0,0.000	8.433	12.923
chr16	88501365	88501365	G	A	exonic	ZNF469		nonsynonymous SNV	ZNF469:NM_001127464:exon2:c.G7403A:p.R2468Q								0												175	94	0.349	226	0	0.000	1.49455380628095941e-29	0.521	---	236,154,82,0.347	194,194,0,0.000	24.724	60
chr16	89357087	89357087	G	A	exonic	ANKRD11		nonsynonymous SNV	ANKRD11:NM_001256183:exon6:c.C547T:p.R183C,ANKRD11:NM_013275:exon6:c.C547T:p.R183C,ANKRD11:NM_001256182:exon7:c.C547T:p.R183C	Score=516;Name=lod=167							0.09	0.99964	C	0.99	D	1.0	D	1.0	D	0.993971	D	5.28	157	79	0.335	205	0	0.000	3.44864779988283714e-25	0.532	---	187,125,62,0.332	158,157,0,0.000	18.692	60
chr17	3030772	3030772	T	A	exonic	OR1G1		nonsynonymous SNV	OR1G1:NM_003555:exon1:c.A74T:p.K25M								0.13	0.083555	N	0.9	T	0.0	B	0.5828	NA	7.51E-4	N	-0.709	116	43	0.270	162	0	0.000	2.74489915267254119e-15	0.256	---	129,94,35,0.271	136,135,0,0.000	12.071	60
chr17	7579350	7579350	A	C	exonic	TP53		nonsynonymous SNV	TP53:NM_001126118:exon3:c.T220G:p.F74V,TP53:NM_000546:exon4:c.T337G:p.F113V,TP53:NM_001126112:exon4:c.T337G:p.F113V,TP53:NM_001126113:exon4:c.T337G:p.F113V,TP53:NM_001126114:exon4:c.T337G:p.F113V,TP53:NM_001276695:exon4:c.T220G:p.F74V,TP53:NM_001276696:exon4:c.T220G:p.F74V,TP53:NM_001276760:exon4:c.T220G:p.F74V,TP53:NM_001276761:exon4:c.T220G:p.F74V	Score=519;Name=lod=171				ID=COSM11498,COSM165071,COSM165070;OCCURENCE=1(breast),1(lung),1(upper_aerodigestive_tract),1(oesophagus),1(central_nervous_system)			0	0.998703	C	1.0	D	1.0	D	1.0	D	0.999985	D	4.17	123	58	0.320	141	0	0.000	2.83082205403973303e-17	0.638	---	156,104,52,0.333	117,117,0,0.000	14.542	11.629
chr17	7979528	7979528	G	A	exonic	ALOX12B		synonymous SNV	ALOX12B:NM_001139:exon11:c.C1497T:p.R499R			0.000154																	128	65	0.337	166	0	0.000	7.37392073771044793e-21	0.523	---	152,101,51,0.336	140,140,0,0.000	16.396	60
chr17	18024037	18024037	G	A	exonic	MYO15A		synonymous SNV	MYO15A:NM_016239:exon2:c.G1923A:p.A641A																				84	55	0.396	141	0	0.000	2.17849277316166216e-20	0.200	---	119,74,45,0.378	117,117,0,0.000	15.464	15.256
chr17	30325780	30325780	C	T	exonic	SUZ12		synonymous SNV	SUZ12:NM_015355:exon16:c.C1978T:p.L660L	Score=744;Name=lod=1413																			112	48	0.300	117	0	0.000	1.97627464569123278e-13	0.479	---	134,95,39,0.291	97,97,0,0.000	10.264	15.477
chr17	43481008	43481008	T	G	exonic	ARHGAP27		nonsynonymous SNV	ARHGAP27:NM_199282:exon8:c.A592C:p.K198Q	Score=284;Name=lod=19							0.19	0.998266	C	0.83	T	0.984	D	1.0	D	0.758817	NA	4.55	97	40	0.292	105	0	0.000	8.55585052942999105e-12	0.500	---	111,77,33,0.300	88,88,0,0.000	9.419	12.971
chr17	48227693	48227693	A	C	exonic	PPP1R9B		unknown	UNKNOWN	Score=688;Name=lod=830							0												67	58	0.464	122	0	0.000	1.44528567065952541e-21	0.362	---	122,68,54,0.443	112,110,0,0.000	18.196	60
chr17	74288293	74288293	G	A	exonic	QRICH2		nonsynonymous SNV	QRICH2:NM_032134:exon4:c.C2017T:p.R673C								0.07	0.990206	C	0.95	T	0.854	D	0.872553	NA	4.6E-5	N	2.62	288	93	0.244	393	0	0.000	3.5318636831961381e-32	0.613	---	351,251,91,0.266	331,329,0,0.000	29.581	60
chr18	22804315	22804315	C	T	exonic	ZNF521		synonymous SNV	ZNF521:NM_015461:exon4:c.G3567A:p.S1189S	Score=572;Name=lod=282		0.000077	0.0005	ID=COSM1179654;OCCURENCE=1(prostate)		rs151163286													52	58	0.527	180	1	0.006	5.00571023097020175e-29	0.724	1.000	96,46,50,0.521	151,150,1,0.007	23.470	60
chr18	55024403	55024403	C	T	exonic	ST8SIA3		nonsynonymous SNV	ST8SIA3:NM_015879:exon3:c.C562T:p.R188C	Score=769;Name=lod=1776				ID=COSM989116;OCCURENCE=1(endometrium)			0	0.999241	C	1.0	D	1.0	D	1.0	D	0.999981	D	5.61	63	77	0.550	160	0	0.000	5.54357177485912338e-33	0.506	---	115,51,64,0.557	142,141,0,0.000	28.108	60
chr18	70209205	70209205	C	A	exonic	CBLN2		nonsynonymous SNV	CBLN2:NM_182511:exon3:c.G191T:p.C64F	Score=674;Name=lod=729							0	0.997802	C	1.0	D	0.999	D	1.0	D	0.999199	D	2.86	78	64	0.451	165	0	0.000	1.86879581804768677e-26	0.469	---	127,70,57,0.449	149,149,0,0.000	23.029	60
chr19	2115357	2115357	A	T	exonic	AP3D1		nonsynonymous SNV	AP3D1:NM_001261826:exon20:c.T2210A:p.L737Q,AP3D1:NM_003938:exon20:c.T2210A:p.L737Q	Score=590;Name=lod=333							0.5	0.996533	C	0.854968	NA	0.608982	NA	0.954977	N	0.60167	D	4.32	148	75	0.336	207	0	0.000	3.27334060051280299e-25	0.453	---	192,130,62,0.323	183,183,0,0.000	20.518	60
chr19	8486730	8486730	G	A	exonic	MARCH2		synonymous SNV	MARCH2:NM_001005415:exon2:c.G6A:p.T2T,MARCH2:NM_001005416:exon2:c.G6A:p.T2T,MARCH2:NM_016496:exon3:c.G6A:p.T2T	Score=541;Name=lod=210			0.0009			rs201174087													80	19	0.192	107	0	0.000	3.33894417576641207e-07	0.737	---	84,67,17,0.202	95,95,0,0.000	5.999	6.729
chr19	11141453	11141453	G	T	exonic	SMARCA4		stopgain	SMARCA4:NM_001128845:exon24:c.G3430T:p.E1144X,SMARCA4:NM_001128846:exon24:c.G3430T:p.E1144X,SMARCA4:NM_001128847:exon24:c.G3430T:p.E1144X,SMARCA4:NM_001128848:exon24:c.G3430T:p.E1144X,SMARCA4:NM_001128849:exon25:c.G3430T:p.E1144X,SMARCA4:NM_003072:exon25:c.G3430T:p.E1144X,SMARCA4:NM_001128844:exon26:c.G3430T:p.E1144X	Score=529;Name=lod=188							0.07	0.999292	C	0.903812	NA	0.735443	NA	0.999998	D	1.0	A	4.24	64	38	0.373	91	0	0.000	6.90533894296562503e-13	0.605	---	81,49,32,0.395	75,75,0,0.000	10.698	60
chr19	21131995	21131995	G	T	exonic	ZNF85		synonymous SNV	ZNF85:NM_001256173:exon3:c.G483T:p.T161T,ZNF85:NM_003429:exon4:c.G675T:p.T225T,ZNF85:NM_001256171:exon5:c.G765T:p.T255T	Score=432;Name=lod=76																			117	23	0.164	160	0	0.000	8.55673986120634057e-09	0.391	---	123,99,15,0.132	142,142,0,0.000	5.507	7.222
chr19	21132007	21132007	T	C	exonic	ZNF85		synonymous SNV	ZNF85:NM_001256173:exon3:c.T495C:p.P165P,ZNF85:NM_003429:exon4:c.T687C:p.P229P,ZNF85:NM_001256171:exon5:c.T777C:p.P259P																				123	17	0.121	161	0	0.000	1.28513437548051807e-06	0.353	---	119,102,8,0.073	138,137,1,0.007	1.929	8.299
chr19	21132041	21132041	C	T	exonic	ZNF85		stopgain	ZNF85:NM_001256173:exon3:c.C529T:p.Q177X,ZNF85:NM_003429:exon4:c.C721T:p.Q241X,ZNF85:NM_001256171:exon5:c.C811T:p.Q271X								0.16	0.833287	N	0.891068	NA	0.702488	NA	0.967917	NA	1.0	D	0.0876	121	16	0.117	182	0	0.000	7.89479875252347052e-07	0.500	---	117,102,9,0.081	151,151,0,0.000	3.441	9.653
chr19	21132042	21132042	A	G	exonic	ZNF85		nonsynonymous SNV	ZNF85:NM_001256173:exon3:c.A530G:p.Q177R,ZNF85:NM_003429:exon4:c.A722G:p.Q241R,ZNF85:NM_001256171:exon5:c.A812G:p.Q271R								0.4	0.832517	N	0.51	T	0.0010	B	0.803084	NA	8.31E-4	N	0.0876	123	16	0.115	185	0	0.000	7.82159878688459716e-07	0.500	---	118,103,9,0.080	152,152,0,0.000	3.435	10.213
chr19	21132051	21132051	A	C	exonic	ZNF85		nonsynonymous SNV	ZNF85:NM_001256173:exon3:c.A539C:p.N180T,ZNF85:NM_003429:exon4:c.A731C:p.N244T,ZNF85:NM_001256171:exon5:c.A821C:p.N274T								0.63	0.077085	N	0.27	T	0.0	B	0.60689	NA	0.010061	N	-0.627	127	22	0.148	177	0	0.000	1.33597536692313886e-08	0.591	---	128,107,15,0.123	149,149,0,0.000	5.417	6.619
chr19	21132057	21132057	T	C	exonic	ZNF85		nonsynonymous SNV	ZNF85:NM_001256173:exon3:c.T545C:p.I182T,ZNF85:NM_003429:exon4:c.T737C:p.I246T,ZNF85:NM_001256171:exon5:c.T827C:p.I276T								1	0.062513	N	0.0	T	0.0	B	0.612735	NA	0.005363	N	-1.28	119	29	0.196	171	0	0.000	4.18263296085345953e-11	0.621	---	136,106,22,0.172	145,145,0,0.000	7.691	11.565
chr19	21132069	21132069	A	G	exonic	ZNF85		nonsynonymous SNV	ZNF85:NM_001256173:exon3:c.A557G:p.K186R,ZNF85:NM_003429:exon4:c.A749G:p.K250R,ZNF85:NM_001256171:exon5:c.A839G:p.K280R	Score=417;Name=lod=66							0.98	0.077085	N	0.24	T	0.0	B	0.606818	NA	0.001435	N	-1.6	121	33	0.214	165	0	0.000	5.02600745452577127e-12	0.636	---	142,109,27,0.199	143,143,0,0.000	9.063	60
chr19	30935326	30935326	G	A	exonic	ZNF536		nonsynonymous SNV	ZNF536:NM_014717:exon2:c.G857A:p.R286H	Score=566;Name=lod=265							0.13	0.999611	C	0.76	T	0.999	D	1.0	D	0.92431	D	5.23	259	121	0.318	312	0	0.000	1.03843082651487419e-36	0.463	---	347,237,109,0.315	282,282,0,0.000	32.142	60
chr19	36431007	36431007	G	A	exonic	LRFN3		nonsynonymous SNV	LRFN3:NM_024509:exon2:c.G680A:p.R227H	Score=371;Name=lod=43				ID=COSM1393016;OCCURENCE=1(large_intestine)			0.11	0.998981	C	0.91	T	0.927	D	0.994274	N	0.327691	N	4.5	167	48	0.223	226	0	0.000	5.1200259029711186e-17	0.479	---	194,147,47,0.242	185,184,0,0.000	14.935	14.699
chr19	48035489	48035489	G	A	exonic	ZNF541		nonsynonymous SNV	ZNF541:NM_001277075:exon9:c.C3197T:p.P1066L	Score=489;Name=lod=130							0												82	59	0.418	100	0	0.000	4.42495173839191374e-17	0.458	---	109,64,45,0.413	80,80,0,0.000	12.880	60
chr20	21687676	21687676	T	C	exonic	PAX1		nonsynonymous SNV	PAX1:NM_001257096:exon2:c.T887C:p.L296P,PAX1:NM_006192:exon2:c.T887C:p.L296P	Score=594;Name=lod=346							0	0.996353	C	1.0	D	0.989	D	1.0	D	0.788643	NA	4.66	250	80	0.242	222	0	0.000	1.95467755188659891e-20	0.363	---	277,208,69,0.249	191,190,0,0.000	17.312	60
chr20	30388802	30388802	C	G	exonic	TPX2		stopgain	TPX2:NM_012112:exon18:c.C2163G:p.Y721X	Score=559;Name=lod=249							0.01	0.951026	C	0.859457	NA	0.630603	NA	0.999981	D	0.673106	NA	3.02	183	33	0.153	103	0	0.000	1.65016374608584872e-06	0.545	---	176,150,25,0.143	81,81,0,0.000	4.250	13.683
chr20	37353400	37353400	C	T	exonic	SLC32A1		synonymous SNV	SLC32A1:NM_080552:exon1:c.C33T:p.N11N	Score=554;Name=lod=237																			316	76	0.194	189	0	0.000	9.94068357257096742e-15	0.645	---	332,269,62,0.187	153,152,0,0.000	10.795	12.074
chr20	39316944	39316944	G	A	exonic	MAFB		synonymous SNV	MAFB:NM_005461:exon1:c.C547T:p.L183L	Score=626;Name=lod=466																			338	90	0.210	306	2	0.006	8.95828282116938569e-21	0.589	0.500	360,278,82,0.228	261,260,1,0.004	19.476	15.955
chr20	44672526	44672526	G	A	exonic	SLC12A5		nonsynonymous SNV	SLC12A5:NM_001134771:exon11:c.G1417A:p.V473I,SLC12A5:NM_020708:exon11:c.G1348A:p.V450I	Score=578;Name=lod=299							0.12	0.998548	C	0.99	D	0.026	B	0.999996	D	0.98588	D	3.71	75	87	0.537	90	0	0.000	1.4880923858440148e-22	0.552	---	154,67,84,0.556	83,83,0,0.000	21.161	60
chr20	44672565	44672565	C	T	exonic	SLC12A5		nonsynonymous SNV	SLC12A5:NM_001134771:exon11:c.C1456T:p.R486W,SLC12A5:NM_020708:exon11:c.C1387T:p.R463W	Score=578;Name=lod=299				ID=COSM1265675;OCCURENCE=1(oesophagus)			0	0.949653	N	1.0	D	0.999	D	1.0	D	0.999828	D	2.58	67	67	0.500	76	0	0.000	3.44000277450667102e-17	0.582	---	129,59,66,0.528	70,70,0,0.000	16.490	60
chr20	61443643	61443643	G	A	exonic	OGFR		nonsynonymous SNV	OGFR:NM_007346:exon7:c.G676A:p.E226K	Score=503;Name=lod=147							0.01	0.97949	C	0.95	T	0.97	D	0.999794	D	0.046369	N	3.22	243	45	0.156	137	0	0.000	9.82919437893350937e-09	0.511	---	238,196,41,0.173	110,110,0,0.000	7.012	4.932
chr21	46117746	46117746	C	T	exonic	KRTAP10-12		synonymous SNV	KRTAP10-12:NM_198699:exon1:c.C630T:p.P210P			0.008934	0.01		0.0082	rs112431728													326	55	0.144	329	0	0.000	2.80503037613684007e-16	0.382	---	327,278,49,0.150	280,280,0,0.000	13.738	10.203
chr22	41752751	41752751	G	A	exonic	ZC3H7B		nonsynonymous SNV	ZC3H7B:NM_017590:exon22:c.G2620A:p.D874N	Score=586;Name=lod=321							0.01	0.999569	C	0.99	D	0.293	P	0.998554	N	0.103733	N	5.14	192	85	0.307	216	0	0.000	7.2226126926556376e-25	0.529	---	234,163,71,0.303	178,178,0,0.000	19.625	60
chrX	11139907	11139907	G	A	exonic	HCCS		nonsynonymous SNV	HCCS:NM_001122608:exon7:c.G784A:p.A262T,HCCS:NM_001171991:exon7:c.G784A:p.A262T,HCCS:NM_005333:exon7:c.G784A:p.A262T	Score=559;Name=lod=250							0.14	0.994179	C	0.9	T	0.0080	B	0.999999	D	0.999958	D	4.26	39	53	0.576	58	0	0.000	1.09225800488398614e-15	0.509	---	75,35,40,0.533	48,48,0,0.000	10.860	12.381
chrX	34149231	34149231	G	T	exonic	FAM47A		nonsynonymous SNV	FAM47A:NM_203408:exon1:c.C1165A:p.P389T								0.02	0.87527	N	0.82	T	0.956	D	0.851634	NA	0.001993	N	0.176	58	201	0.776	137	0	0.000	6.39714825363571442e-60	0.493	---	228,50,178,0.781	116,116,0,0.000	51.207	60