"Checked" "Master" "Accession" "Description" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score MS Amanda 2.0: MS Amanda 2.0" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): MS Amanda 2.0" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "Reactome Pathways" "WikiPathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundances (Grouped): 126" "Abundances (Grouped): 127N" "Abundances (Grouped): 127C" "Abundances (Grouped): 128N" "Abundances (Grouped): 128C" "Abundances (Grouped): 129N" "Abundances (Grouped): 129C" "Abundances (Grouped): 130N" "Abundances (Grouped): 130C" "Abundances (Grouped): 131N" "Abundances (Grouped): 131C" "Abundances (Grouped) CV [%]: 126" "Abundances (Grouped) CV [%]: 127N" "Abundances (Grouped) CV [%]: 127C" "Abundances (Grouped) CV [%]: 128N" "Abundances (Grouped) CV [%]: 128C" "Abundances (Grouped) CV [%]: 129N" "Abundances (Grouped) CV [%]: 129C" "Abundances (Grouped) CV [%]: 130N" "Abundances (Grouped) CV [%]: 130C" "Abundances (Grouped) CV [%]: 131N" "Abundances (Grouped) CV [%]: 131C" "Found in Sample: F28: 126, Sample" "Found in Sample: F28: 127N, Sample" "Found in Sample: F28: 127C, Sample" "Found in Sample: F28: 128N, Sample" "Found in Sample: F28: 128C, Sample" "Found in Sample: F28: 129N, Sample" "Found in Sample: F28: 129C, Sample" "Found in Sample: F28: 130N, Sample" "Found in Sample: F28: 130C, Sample" "Found in Sample: F28: 131N, Sample" "Found in Sample: F28: 131C, Sample" "# Protein Groups" "Modifications" "False" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "61" "68" "227" "68" "1014" "113.0" "8.88" "44276.38" "403.66" "62" "53" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "SUMOylation of DNA damage response and repair proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome; A network map of Macrophage-stimulating protein (MSP) signaling" "26" "0" "8864.5" "6918.4" "8715.5" "18529.0" "11025.2" "8090.6" "15854.8" "7036.7" "11528.5" "62695.9" "92761.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "77" "56" "186" "55" "528" "59.1" "7.05" "33184.39" "338.71" "49" "45" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Cytosolic tRNA aminoacylation" "Nephrotic syndrome" "2" "1" "2261.8" "1974.6" "2984.3" "7031.7" "3815.8" "2443.4" "4753.8" "3522.3" "11761.3" "82184.6" "72360.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "70" "28" "154" "28" "216" "23.7" "9.41" "26315.70" "325.89" "22" "28" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "4" "0" "2051.3" "1822.5" "2528.6" "4986.5" "3113.7" "2526.2" "5533.4" "9269.0" "25222.6" "48626.5" "34682.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "36" "54" "116" "50" "1657" "189.1" "6.48" "23103.72" "246.83" "45" "45" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "RHOC GTPase cycle; RHOA GTPase cycle; Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "25" "4" "1157.6" "1088.2" "1624.7" "4623.1" "2344.5" "1325.3" "2317.8" "1652.1" "4873.4" "33565.1" "33280.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "46" "39" "89" "39" "1010" "107.7" "6.70" "14113.54" "236.49" "29" "37" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Purine ribonucleoside monophosphate biosynthesis" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "4" "0" "796.4" "745.7" "1079.2" "3419.1" "1573.3" "1084.7" "2463.4" "3939.2" "7256.4" "24123.9" "25909.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "66" "25" "95" "25" "335" "36.0" "8.46" "15452.96" "233.38" "18" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Glycolysis; Gluconeogenesis" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways" "15" "0" "5478.7" "4843.7" "6638.9" "12539.0" "6977.6" "5462.0" "11604.3" "4819.5" "5642.2" "16090.5" "10617.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "47" "35" "111" "29" "644" "66.0" "8.12" "19821.22" "220.56" "28" "33" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Formation of the cornified envelope; Neutrophil degranulation" "Corticotropin-releasing hormone signaling pathway" "4" "6" "20105.5" "22464.4" "8717.8" "5405.2" "3457.6" "2855.0" "7748.3" "2197.9" "3632.1" "7222.9" "3972.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "72" "21" "111" "21" "228" "26.2" "8.25" "21006.65" "217.37" "17" "20" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "" "Gastric cancer network 2" "1" "0" "2191.4" "1773.7" "2490.7" "5342.7" "2959.7" "2275.0" "3956.9" "3227.5" "9609.6" "36621.6" "36971.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "47" "39" "103" "38" "858" "95.3" "6.83" "20601.14" "216.45" "33" "33" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "9" "1" "3005.5" "2731.6" "3868.5" "11609.1" "5420.8" "3243.7" "6032.7" "3389.4" "3791.6" "11541.8" "15736.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "40" "33" "93" "33" "910" "101.9" "7.17" "16738.37" "209.32" "27" "33" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "Signaling by BRAF and RAF1 fusions" "VEGFA-VEGFR2 signaling" "2" "0" "2658.4" "2448.1" "2947.2" "6330.2" "3446.3" "2902.7" "5221.6" "2497.5" "3404.6" "14780.1" "17647.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "49" "35" "106" "28" "646" "70.9" "5.52" "19851.30" "187.89" "32" "34" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "Clathrin-mediated endocytosis; Neutrophil degranulation; Late endosomal microautophagy; AUF1 (hnRNP D0) binds and destabilizes mRNA; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome" "24" "7" "4257.1" "4146.9" "6553.9" "24961.6" "8960.6" "3829.7" "9591.7" "4948.1" "5653.8" "15119.4" "11898.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07437" "Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2" "63" "22" "90" "6" "444" "49.6" "4.89" "17750.51" "176.62" "19" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "203068" "ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067" "TUBB" "hsa:203068; P05218; P07437; Q8WUC1; Q9CY33" "Potential therapeutics for SARS; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease" "14" "22" "1593.8" "1656.7" "2161.2" "7982.1" "3049.6" "1448.6" "3007.9" "2145.0" "2060.5" "7098.8" "6607.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "12" "45" "93" "45" "4128" "468.8" "7.12" "19468.07" "173.04" "44" "40" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "14" "0" "2220.1" "2085.0" "2660.3" "7902.4" "3631.1" "2242.9" "4130.0" "2648.9" "3003.9" "11834.5" "12359.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "39" "32" "67" "32" "1037" "117.3" "6.92" "10669.38" "166.72" "17" "31" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "Mitochondrial protein import" "" "1" "0" "840.9" "738.9" "1067.5" "3138.6" "1522.5" "925.7" "1400.1" "974.5" "2215.3" "17095.4" "26989.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "60" "26" "68" "26" "531" "57.9" "7.84" "14017.17" "164.65" "20" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Neutrophil degranulation" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis" "9" "0" "1601.3" "1514.9" "2280.5" "8631.0" "3207.5" "1508.6" "3916.6" "2034.1" "2451.6" "8381.8" "9013.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "44" "31" "75" "31" "723" "83.4" "6.67" "11866.67" "164.01" "21" "29" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "Cytosolic tRNA aminoacylation" "" "1" "0" "961.6" "868.1" "1371.2" "3857.3" "1796.2" "1086.1" "1680.7" "1027.0" "1585.2" "15105.4" "31741.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "60" "28" "87" "28" "435" "49.6" "9.54" "17184.75" "162.06" "24" "23" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Cargo recognition for clathrin-mediated endocytosis; EPH-ephrin mediated repulsion of cells; VLDLR internalisation and degradation; Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "21" "0" "954.1" "835.2" "1113.9" "2589.2" "1499.1" "1317.2" "3515.0" "4765.7" "8423.1" "18818.6" "16567.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "31" "34" "80" "34" "1270" "140.9" "6.84" "15414.85" "160.29" "30" "30" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "mRNA Splicing - Major Pathway; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "MECP2 and associated Rett syndrome; mRNA processing" "5" "0" "1837.9" "1596.3" "2126.6" "4625.2" "2688.8" "1957.5" "3857.5" "1833.4" "2972.5" "14302.7" "15686.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "33" "33" "89" "19" "937" "104.5" "5.38" "16543.04" "158.97" "32" "27" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "Recycling pathway of L1; MHC class II antigen presentation; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "20" "16" "1160.3" "979.3" "1305.1" "3347.2" "1731.9" "1506.1" "4960.3" "6196.4" "12225.4" "29639.9" "22465.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36578" "60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "58" "33" "84" "33" "427" "47.7" "11.06" "15993.24" "151.82" "29" "24" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "7142.0" "6253.3" "7424.0" "15033.0" "8401.8" "6160.2" "13166.6" "5759.5" "6627.5" "15486.1" "8659.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "33" "39" "85" "39" "1233" "143.1" "7.64" "14289.94" "148.61" "34" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Estrogen-dependent gene expression; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome causing genes; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "21" "0" "2536.0" "2217.0" "2783.6" "6173.7" "3496.8" "2560.0" "5055.0" "2374.7" "3380.4" "14756.9" "13742.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "43" "26" "76" "26" "548" "62.9" "6.25" "16545.64" "148.47" "22" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response" "2" "0" "1012.3" "946.5" "1340.5" "3239.0" "1610.5" "1126.1" "2344.5" "1208.0" "2874.7" "22902.3" "25795.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P68363" "Tubulin alpha-1B chain OS=Homo sapiens OX=9606 GN=TUBA1B PE=1 SV=1" "46" "20" "67" "1" "451" "50.1" "5.06" "11733.71" "148.18" "16" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10376" "ENSG00000123416" "TUBA1B" "hsa:10376; P04687; P05209; P68363; Q27I68; Q8WU19" "Recruitment of NuMA to mitotic centrosomes; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; HCMV Early Events; Intraflagellar transport; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Hedgehog 'off' state; RHOH GTPase cycle" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "22" "1794.4" "1810.0" "2429.6" "9025.5" "3505.3" "1662.0" "3598.7" "2471.7" "2140.3" "9069.2" "9099.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "47" "20" "77" "20" "472" "51.1" "8.40" "13350.18" "145.71" "14" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "GTP hydrolysis and joining of the 60S ribosomal subunit; PERK regulates gene expression; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; ABC-family proteins mediated transport; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "12" "0" "785.0" "643.4" "948.2" "2334.4" "1209.5" "829.2" "1364.6" "815.9" "1468.0" "19606.2" "24504.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "49" "18" "78" "2" "445" "49.8" "4.89" "14442.54" "144.06" "16" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; HCMV Early Events; COPI-dependent Golgi-to-ER retrograde traffic; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "41" "0" "66.8" "76.8" "102.7" "512.9" "154.6" "52.3" "155.7" "112.6" "116.8" "319.7" "241.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "35" "31" "74" "20" "939" "103.9" "6.96" "13003.73" "143.87" "26" "27" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "Neutrophil degranulation; Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission" "17" "11" "840.9" "741.4" "1011.2" "2433.5" "1412.6" "1213.8" "3796.9" "5083.3" "9659.7" "17994.8" "14409.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "46" "20" "65" "1" "449" "49.9" "5.10" "11324.49" "143.58" "16" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; HCMV Early Events; COPI-dependent Golgi-to-ER retrograde traffic; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "35" "0" "52.6" "52.3" "81.7" "403.7" "129.3" "58.3" "126.1" "80.3" "64.7" "414.0" "373.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "49" "32" "71" "20" "724" "83.2" "5.03" "13141.74" "142.18" "26" "29" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf02518" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "23" "13" "2166.5" "2216.8" "3396.6" "20062.3" "5858.1" "1663.6" "3333.0" "2862.0" "2682.2" "7226.9" "7033.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EK5" "KIF-binding protein OS=Homo sapiens OX=9606 GN=KIFBP PE=1 SV=1" "58" "27" "60" "26" "621" "71.8" "5.49" "11768.11" "134.91" "20" "23" "cell organization and biogenesis;transport;developmental processes" "cytoskeleton;mitochondrion" "cytoskeletal activity" "Pf12309" "26128" "ENSG00000198954" "KIFBP" "A8K5M8; hsa:26128; Q96EK5; Q9BR89; Q9ULE1; Q9Y428" "" "" "0" "1" "547.4" "481.3" "660.8" "1629.2" "874.6" "672.3" "1322.7" "1706.1" "5406.9" "26209.9" "17113.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "55" "25" "65" "25" "394" "43.8" "6.55" "10690.08" "134.83" "19" "22" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "Neutrophil degranulation" "" "1" "0" "2962.6" "2570.3" "3380.7" "6452.5" "3922.9" "2901.2" "6103.6" "2794.9" "3567.2" "9253.3" "9204.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "64" "21" "64" "6" "318" "34.8" "6.98" "10735.15" "127.91" "17" "18" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "19" "1200.9" "1086.9" "1451.4" "3222.0" "1772.3" "1295.7" "2110.9" "1513.4" "2799.9" "11771.9" "19155.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "10" "37" "68" "37" "4646" "532.1" "6.40" "12282.33" "126.41" "33" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "Separation of Sister Chromatids; Neutrophil degranulation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; HCMV Early Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein" "22" "0" "1774.1" "1694.6" "2202.6" "6463.9" "3058.2" "1640.5" "3318.9" "1986.6" "2191.8" "6229.5" "4909.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "43" "22" "56" "22" "684" "75.4" "6.61" "10983.09" "125.22" "18" "22" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "mRNA decay by 3' to 5' exoribonuclease" "10q11.21q11.23 copy number variation syndrome" "2" "0" "673.8" "551.7" "790.7" "1874.4" "1034.7" "709.6" "1339.9" "1857.6" "6159.0" "18027.0" "13205.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "44" "28" "63" "22" "641" "70.0" "5.66" "10638.32" "121.27" "22" "27" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; Attenuation phase" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection; CKAP4 signaling pathway map" "12" "0" "2269.0" "2160.0" "3433.3" "11773.1" "4514.5" "2116.7" "5060.7" "2522.8" "2826.5" "7281.9" "5654.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5JSL3" "Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2" "16" "33" "74" "32" "2073" "237.5" "7.74" "15076.56" "119.24" "28" "29" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "139818" "ENSG00000147251" "DOCK11" "A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "" "3" "1" "1448.8" "1232.8" "1629.5" "3631.7" "2260.3" "2194.7" "6700.2" "6182.6" "10320.9" "15331.3" "8500.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12532" "Creatine kinase U-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT1A PE=1 SV=1" "57" "22" "58" "22" "417" "47.0" "8.34" "10786.54" "118.00" "18" "20" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00217, Pf02807" "1159; 548596" "ENSG00000223572; ENSG00000237289" "CKMT1A; CKMT1B" "B4DIT8; B7ZA09; hsa:1159; hsa:548596; P12532; Q0VAM3; Q32NF6; Q53FC4" "Creatine metabolism" "" "1" "0" "3786.7" "3181.9" "3677.4" "4882.9" "3828.6" "3582.8" "5009.8" "3020.8" "3431.2" "6820.6" "5793.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "41" "26" "66" "16" "639" "65.4" "8.00" "12373.40" "117.36" "24" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "Formation of the cornified envelope" "" "2" "8" "15956.3" "10229.3" "7506.3" "2440.3" "1160.8" "1172.8" "4178.1" "1312.0" "1862.2" "3847.2" "3393.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "61" "21" "56" "20" "315" "36.1" "5.08" "9132.80" "115.82" "18" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "19" "1" "1062.0" "892.1" "1193.8" "2620.0" "1495.3" "1089.3" "1873.1" "851.1" "1586.9" "16602.7" "19045.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "29" "24" "58" "13" "977" "107.5" "7.03" "9287.44" "113.96" "20" "22" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission" "20" "0" "310.4" "272.7" "397.7" "949.0" "536.9" "439.2" "1223.3" "1810.7" "3273.6" "7422.5" "6192.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "53" "17" "46" "16" "353" "37.4" "8.95" "7899.77" "113.25" "14" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "mRNA processing" "4" "1" "2629.8" "2248.4" "2435.0" "6675.4" "3111.3" "1986.6" "3978.6" "2154.2" "2167.7" "7134.4" "4897.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "46" "24" "46" "24" "677" "76.2" "7.03" "6518.11" "113.11" "16" "22" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex" "DNA repair pathways, full network" "5" "0" "705.9" "576.3" "821.6" "2089.9" "1124.4" "733.5" "1310.9" "927.3" "2275.3" "11564.7" "9983.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "74" "14" "68" "14" "105" "11.7" "9.57" "13695.71" "112.14" "14" "12" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "36" "0" "4546.2" "4235.0" "5019.3" "9161.0" "5465.0" "4139.1" "6205.7" "4172.9" "5646.0" "11480.1" "9195.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "56" "21" "59" "21" "224" "25.2" "9.28" "10931.94" "111.49" "20" "17" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "2008.1" "1527.8" "1828.0" "4556.0" "2255.2" "1778.3" "4383.3" "1825.2" "3785.6" "18950.1" "19525.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P68104" "Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1" "50" "21" "54" "10" "462" "50.1" "9.01" "7433.37" "111.05" "16" "19" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "1915" "ENSG00000156508" "EEF1A1" "hsa:1915; P04719; P04720; P68104; Q6IQ15" "Neutrophil degranulation; Peptide chain elongation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; SARS-CoV-1 modulates host translation machinery" "Translation factors; Fragile X syndrome; 2q37 copy number variation syndrome" "10" "13" "3784.3" "3334.4" "3838.7" "9498.1" "4404.7" "3030.7" "4823.3" "3291.0" "3568.8" "10286.0" "11307.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "40" "25" "51" "25" "736" "79.6" "8.84" "9625.24" "110.63" "21" "24" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "10" "0" "2214.9" "1846.7" "2186.0" "4514.9" "2532.2" "2149.0" "3403.5" "1837.3" "2258.9" "8400.7" "7451.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "43" "24" "56" "24" "609" "69.8" "6.64" "12696.06" "110.29" "21" "20" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "9" "0" "2243.9" "1999.1" "2704.8" "8639.6" "3821.7" "2038.8" "4645.3" "2302.5" "2509.8" "8041.4" "6611.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "55" "26" "61" "19" "364" "39.4" "8.09" "13472.06" "108.13" "24" "21" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; Platelet degranulation" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways" "10" "6" "4183.7" "3283.0" "5179.2" "13674.9" "6287.6" "3831.7" "9956.6" "3559.3" "4453.1" "18456.1" "12231.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "38" "39" "70" "39" "710" "76.6" "4.70" "13279.32" "105.25" "35" "30" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Major pathway of rRNA processing in the nucleolus and cytosol" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "3" "0" "9697.0" "7299.4" "8613.0" "19692.1" "11086.1" "7499.5" "10518.4" "5621.7" "7559.5" "12689.1" "9539.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "42" "23" "61" "22" "623" "62.0" "5.24" "11277.85" "104.81" "18" "20" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00038" "3857" "ENSG00000171403" "KRT9" "hsa:3857; O00109; P35527; Q0IJ47; Q14665" "Formation of the cornified envelope" "" "2" "2" "12247.9" "18890.2" "5498.3" "3301.6" "2732.2" "2565.9" "4241.6" "1291.9" "3106.1" "5642.9" "2455.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08865" "40S ribosomal protein SA OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "63" "15" "37" "15" "295" "32.8" "4.87" "5454.15" "103.63" "10" "14" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1181.8" "1082.2" "1344.3" "2615.1" "1558.9" "1226.0" "2345.8" "1107.9" "1255.1" "2601.5" "2067.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62701" "40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "66" "25" "59" "25" "263" "29.6" "10.15" "10306.16" "103.30" "23" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf01479, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "4334.3" "3787.8" "4479.8" "9891.1" "5466.7" "3957.5" "8174.5" "3867.4" "3983.0" "11272.1" "7489.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "44" "29" "59" "29" "573" "61.0" "5.87" "11380.38" "101.79" "26" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Sudden infant death syndrome (SIDS) susceptibility pathways" "4" "0" "1761.6" "1568.4" "2726.3" "17311.7" "4924.3" "1025.8" "2551.4" "2295.3" "2163.2" "4875.3" "4893.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "30" "21" "52" "15" "584" "58.8" "5.21" "9035.69" "100.82" "16" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "Formation of the cornified envelope" "" "2" "8" "10177.7" "6952.6" "4541.2" "2580.4" "1240.0" "1024.5" "4967.1" "1015.4" "1281.8" "2498.7" "1940.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61247" "40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "74" "27" "67" "27" "264" "29.9" "9.73" "12968.07" "100.41" "24" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "5049.4" "4372.1" "4974.0" "10699.1" "5871.3" "4357.0" "8680.2" "4465.3" "4717.1" "12792.4" "8628.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "32" "31" "68" "31" "1152" "120.9" "5.43" "14114.43" "99.07" "30" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "hsa:4134; P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "2" "0" "4804.9" "3611.1" "4724.0" "9014.4" "5515.1" "4114.6" "7362.9" "3023.1" "4200.9" "8594.8" "5039.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "44" "19" "55" "19" "333" "38.4" "5.80" "11016.34" "96.01" "17" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "ABC-family proteins mediated transport; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "14" "0" "889.2" "779.5" "1055.6" "2637.1" "1398.7" "930.9" "1643.8" "948.9" "1727.9" "18553.9" "22749.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "28" "18" "50" "18" "732" "82.7" "5.81" "9775.51" "95.93" "16" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; 10q11.21q11.23 copy number variation syndrome" "10" "0" "1661.4" "1494.3" "2049.5" "6634.0" "3002.9" "1590.3" "3582.7" "1579.0" "1849.3" "6675.9" "5428.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "20" "29" "48" "29" "1512" "170.5" "7.33" "7776.67" "94.69" "21" "24" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "6" "0" "1755.7" "1665.7" "2364.6" "8327.0" "3495.9" "1516.4" "3013.3" "1903.0" "1997.7" "8390.3" "11172.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46777" "60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "43" "15" "59" "15" "297" "34.3" "9.72" "14597.54" "94.66" "15" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "4945.2" "4064.6" "5210.2" "11097.1" "6108.8" "4088.4" "8661.8" "3662.3" "4589.7" "11034.8" "5633.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NC51" "Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "41" "20" "48" "20" "408" "44.9" "8.65" "10350.23" "93.54" "17" "17" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "1" "0" "4577.4" "3741.6" "4305.1" "7475.8" "4806.9" "3920.9" "7189.0" "3098.9" "3855.9" "8157.5" "4815.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "33" "23" "51" "11" "732" "84.6" "5.02" "9379.52" "92.81" "21" "21" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf02518" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway" "67" "0" "543.1" "558.4" "887.1" "5215.4" "1515.8" "361.2" "871.4" "699.7" "680.3" "1965.9" "1913.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "29" "21" "48" "21" "783" "85.9" "7.77" "9446.73" "91.30" "17" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "" "Pyrimidine metabolism; miRNA degrading enzymes" "2" "0" "2054.7" "1692.3" "2158.7" "4163.0" "2428.1" "1983.7" "3656.5" "1666.1" "2175.2" "5997.5" "4207.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "57" "22" "50" "22" "417" "44.6" "8.10" "9222.24" "90.01" "18" "18" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis" "11" "0" "1282.9" "1202.8" "1815.2" "7510.0" "2743.1" "918.4" "1583.3" "1443.5" "1794.0" "7759.9" "18693.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "38" "20" "50" "20" "553" "59.7" "9.13" "10883.77" "89.32" "17" "18" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "6" "0" "1963.2" "1888.4" "2550.6" "8889.9" "3727.0" "1898.3" "3394.9" "2286.8" "2896.9" "6928.6" "7578.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "32" "20" "50" "19" "707" "76.1" "9.44" "10240.86" "89.11" "17" "19" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "mRNA processing; Type 2 papillary renal cell carcinoma" "4" "0" "3366.6" "2780.2" "3481.9" "5758.4" "4021.5" "3203.4" "5510.8" "2505.3" "3301.1" "6654.0" "4234.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "21" "29" "54" "29" "1382" "166.5" "6.79" "10578.71" "88.85" "25" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "2512.2" "2309.0" "3066.4" "7407.8" "3848.4" "2560.7" "5188.4" "2504.9" "3005.1" "8749.6" "5994.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "39" "21" "49" "19" "471" "54.2" "8.95" "9090.11" "88.69" "17" "20" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "" "mRNA processing" "1" "2" "3092.3" "2379.1" "3105.9" "5131.5" "3583.6" "2721.8" "4674.8" "2137.6" "3146.0" "6209.4" "4267.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "33" "18" "44" "18" "740" "82.4" "7.23" "8986.98" "88.01" "16" "17" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "tRNA processing in the nucleus" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "3" "0" "1880.7" "1561.1" "2091.7" "4330.4" "2419.2" "1814.4" "3174.5" "1481.2" "1993.4" "5313.7" "3526.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P32121" "Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2" "48" "19" "41" "15" "409" "46.1" "7.69" "7640.58" "87.76" "16" "17" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00339, Pf02752" "409" "ENSG00000141480" "ARRB2" "B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6" "Ub-specific processing proteases; Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; Activation of SMO; G alpha (s) signalling events; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "27" "4" "300.3" "245.0" "401.9" "1190.4" "755.3" "736.3" "3187.3" "2625.6" "5047.8" "16835.5" "10667.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "51" "14" "51" "14" "338" "35.5" "8.68" "8873.03" "87.46" "13" "13" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; hsa:4191; O43682; P40926" "Gluconeogenesis; Citric acid cycle (TCA cycle)" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "2783.6" "2327.3" "3252.2" "5586.4" "3289.6" "2169.4" "5150.4" "2279.7" "2605.6" "7549.8" "6886.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "24" "27" "51" "27" "1288" "147.1" "6.79" "10525.74" "86.87" "24" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Ciliary landscape" "3" "0" "1825.2" "1667.3" "2124.7" "5453.4" "2739.4" "1840.6" "3729.8" "1776.1" "2540.6" "8328.4" "6741.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "19" "21" "49" "21" "1217" "141.5" "7.18" "10162.64" "86.05" "20" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "14" "0" "1741.4" "1568.4" "2000.3" "4728.2" "2439.2" "1869.0" "3843.9" "1724.7" "2500.8" "11065.2" "10023.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23396" "40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "65" "15" "47" "15" "243" "26.7" "9.66" "8596.10" "85.52" "14" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1705.7" "1535.4" "1704.6" "3988.7" "2288.9" "1610.2" "3206.6" "1608.9" "1486.9" "5817.5" "4650.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "13" "21" "45" "21" "2032" "225.4" "7.80" "9456.98" "84.89" "18" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "13" "0" "2297.9" "1990.9" "2372.0" "4656.9" "2865.5" "2239.5" "4156.1" "1915.1" "2407.7" "6378.6" "4561.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22234" "Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "32" "15" "45" "15" "425" "47.0" "7.23" "8744.58" "84.08" "12" "13" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Purine ribonucleoside monophosphate biosynthesis" "Metabolic reprogramming in colon cancer" "2" "0" "1156.1" "997.9" "1598.3" "4431.5" "2091.7" "1257.3" "2373.6" "1375.8" "1772.0" "5675.0" "8377.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "36" "22" "50" "16" "636" "70.6" "9.50" "9318.42" "83.46" "21" "20" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Deadenylation of mRNA" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "11" "5" "2402.2" "2163.5" "2763.1" "7374.7" "3707.0" "2242.8" "4698.6" "2239.3" "2471.8" "7198.5" "4676.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49407" "Beta-arrestin-1 OS=Homo sapiens OX=9606 GN=ARRB1 PE=1 SV=2" "43" "16" "35" "12" "418" "47.0" "6.20" "6025.59" "82.07" "13" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00339, Pf02752" "408" "ENSG00000137486" "ARRB1" "B6V9G8; hsa:408; O75625; O75630; P49407; Q2PP20; Q9BTK8" "Ub-specific processing proteases; Activation of SMO; Activated NOTCH1 Transmits Signal to the Nucleus; G alpha (s) signalling events; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Cargo recognition for clathrin-mediated endocytosis; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; MAPK signaling pathway; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "25" "0" "150.3" "144.6" "180.8" "545.5" "356.3" "387.3" "1527.0" "1324.1" "3233.6" "7961.5" "4686.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "29" "21" "45" "20" "679" "73.6" "6.16" "7691.05" "81.66" "19" "19" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "6" "0" "1805.8" "1852.4" "2659.4" "10894.7" "3870.3" "1560.0" "2979.3" "2096.7" "2299.9" "5937.9" "5066.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "36" "26" "52" "25" "662" "73.2" "7.18" "9499.14" "81.32" "23" "20" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Neutrophil degranulation" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "3" "1" "3019.3" "2476.2" "3145.5" "6171.8" "3769.6" "3144.6" "5418.1" "2388.7" "3212.6" "7724.6" "5171.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "36" "13" "35" "13" "504" "55.1" "6.61" "5365.77" "80.94" "10" "13" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "hsa:27339; Q9UMS4" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex" "" "5" "0" "554.6" "495.0" "668.3" "1899.6" "899.4" "560.2" "1083.9" "544.5" "1021.4" "9244.0" "12616.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "20" "18" "36" "17" "1104" "122.8" "5.83" "6330.96" "80.41" "14" "16" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Glycosphingolipid metabolism; RHOF GTPase cycle" "" "7" "1" "424.1" "423.6" "603.9" "1983.8" "1066.8" "940.1" "2483.4" "1820.4" "2840.2" "8086.3" "5764.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "26" "20" "44" "20" "870" "98.0" "7.44" "7731.85" "80.15" "16" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "Clathrin-mediated endocytosis; Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; NGF-stimulated transcription; Golgi Associated Vesicle Biogenesis; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "14" "0" "1100.9" "961.1" "1081.0" "2530.1" "1401.4" "1032.9" "1957.3" "1227.4" "2094.8" "7097.0" "6830.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "39" "22" "46" "22" "558" "61.4" "7.80" "8504.83" "79.89" "19" "17" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension" "7" "0" "3073.4" "2584.8" "3358.8" "5633.9" "3748.7" "2834.4" "6232.0" "2589.3" "2727.6" "7390.6" "4688.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "23" "18" "47" "18" "765" "90.7" "9.31" "8320.19" "79.80" "18" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "SUMOylation of DNA replication proteins" "Ebola virus infection in host" "2" "0" "1358.4" "1159.1" "1450.1" "3416.2" "1870.3" "1298.0" "2446.0" "1135.4" "2053.0" "10727.0" "8686.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27695" "DNA-(apurinic or apyrimidinic site) lyase OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "51" "13" "36" "13" "318" "35.5" "8.12" "8524.36" "79.78" "13" "12" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "10" "0" "957.6" "771.0" "1031.1" "2281.5" "1254.1" "772.1" "1948.0" "861.5" "1330.0" "6171.5" "11048.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "50" "19" "50" "19" "294" "32.6" "4.78" "9311.55" "78.98" "17" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Nuclear events stimulated by ALK signaling in cancer; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; SARS-CoV-1-host interactions" "" "9" "0" "6131.7" "4702.4" "6383.4" "14158.9" "7377.4" "5197.5" "11314.2" "4458.5" "6807.4" "17482.2" "14873.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "44" "16" "45" "3" "318" "34.7" "6.61" "7688.96" "78.77" "13" "13" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "0" "140.8" "133.0" "157.9" "460.4" "241.8" "160.8" "297.3" "200.2" "481.7" "2017.3" "2565.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "24" "23" "43" "23" "1197" "135.6" "8.43" "8087.04" "78.71" "20" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Retinoblastoma gene in cancer" "3" "0" "1649.1" "1456.4" "1926.4" "5313.2" "2515.3" "1731.1" "3344.4" "1524.2" "2256.8" "7758.9" "6017.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "43" "11" "32" "11" "380" "42.6" "8.62" "6028.73" "78.25" "8" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "Base excision repair; DNA repair pathways, full network" "8" "0" "1159.8" "964.7" "1091.5" "2252.9" "1291.8" "899.9" "1816.1" "815.1" "1335.2" "5783.6" "11158.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "25" "15" "37" "15" "845" "95.9" "6.80" "7661.12" "78.06" "13" "14" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005, Pf12848" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "ABC-family proteins mediated transport" "IL-18 signaling pathway" "2" "0" "742.8" "675.2" "787.1" "1591.1" "994.1" "713.4" "1199.0" "632.2" "906.0" "4602.2" "6622.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "43" "13" "39" "13" "359" "39.2" "6.65" "8003.50" "77.08" "12" "13" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "Metabolic reprogramming in colon cancer; Orexin receptor pathway" "6" "0" "1611.7" "1555.1" "2232.0" "4336.0" "2560.3" "1712.0" "4414.0" "1701.1" "1926.2" "5178.4" "2446.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "27" "18" "42" "13" "729" "80.2" "8.27" "7829.15" "76.26" "16" "18" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "SUMOylation of transcription cofactors" "Novel intracellular components of RIG-I-like receptor pathway" "2" "4" "1201.8" "1054.0" "1313.3" "2948.0" "1588.0" "1108.7" "2121.8" "1147.0" "1261.9" "3898.3" "2497.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18124" "60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "51" "18" "46" "18" "248" "29.2" "10.65" "8441.81" "76.10" "17" "16" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "1970.0" "1649.5" "1984.2" "5326.8" "2562.4" "1516.1" "3988.6" "1643.5" "2052.7" "5974.3" "3278.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "38" "20" "41" "20" "505" "55.2" "7.23" "6892.89" "75.79" "17" "19" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "tRNA processing in the nucleus" "Unfolded protein response" "2" "0" "2176.7" "1896.6" "2396.0" "4724.5" "2700.3" "2089.3" "3621.4" "1835.4" "2255.7" "6284.3" "4940.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "16" "19" "37" "19" "1720" "194.7" "7.03" "6676.59" "75.73" "15" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "512.7" "429.7" "547.3" "1313.9" "678.0" "503.0" "949.0" "747.8" "2025.6" "8383.3" "6020.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=2" "21" "22" "48" "8" "949" "104.6" "5.06" "9023.49" "75.68" "21" "17" "" "" "" "" "" "" "" "" "" "" "0" "0" "208.4" "204.1" "272.0" "870.4" "394.7" "271.9" "882.0" "1178.2" "2313.0" "4432.4" "3335.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62081" "40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "63" "13" "30" "13" "194" "22.1" "10.10" "4537.45" "74.91" "8" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; rRNA modification in the nucleus and cytosol" "Cytoplasmic ribosomal proteins" "20" "0" "2361.5" "2119.0" "2518.9" "4858.6" "2622.9" "1783.6" "3851.6" "1916.5" "2213.3" "5131.5" "3679.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "42" "23" "43" "21" "654" "72.3" "5.16" "8790.95" "73.51" "18" "19" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "14" "0" "1587.4" "1592.1" "2399.2" "8945.2" "3330.9" "1534.8" "3065.6" "2086.7" "2263.1" "5547.2" "4834.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q07020" "60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "50" "13" "36" "13" "188" "21.6" "11.72" "6707.79" "71.98" "12" "13" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1612.1" "1270.3" "1658.0" "3511.3" "2173.3" "1642.1" "3467.3" "1331.4" "1570.0" "3708.8" "2249.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26373" "60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "58" "16" "43" "16" "211" "24.2" "11.65" "7697.14" "71.31" "13" "15" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "3463.4" "2842.2" "3542.3" "6611.8" "4079.0" "3068.8" "5858.5" "2396.1" "2855.7" "6237.9" "3465.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "31" "14" "38" "14" "529" "56.5" "5.40" "8624.45" "71.30" "14" "12" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "7" "0" "1375.4" "1235.9" "1774.0" "6764.3" "2666.9" "1380.9" "2289.6" "1587.3" "2030.3" "5385.1" "5607.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "31" "17" "31" "14" "711" "73.1" "7.30" "5274.23" "71.16" "14" "16" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "Pre-implantation embryo" "3" "3" "1202.3" "1027.0" "1671.5" "6750.0" "2500.9" "759.6" "2102.2" "1421.3" "1692.2" "4194.9" "3263.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18621" "60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "51" "13" "42" "12" "184" "21.4" "10.17" "8053.59" "70.82" "13" "13" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "1" "2593.1" "2281.0" "2759.3" "6257.6" "3371.6" "2198.5" "5002.5" "2359.1" "2545.1" "6674.7" "3968.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "23" "15" "43" "4" "564" "60.0" "8.00" "7878.83" "70.57" "15" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "Formation of the cornified envelope" "" "2" "0" "915.0" "267.3" "424.1" "113.3" "120.3" "72.4" "187.8" "57.3" "76.7" "278.4" "163.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "20" "17" "39" "17" "894" "95.3" "8.76" "7240.43" "70.37" "16" "15" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "Regulation of CDH11 gene transcription" "" "1" "0" "1280.7" "1157.6" "1598.6" "5662.9" "2129.1" "1148.4" "2794.9" "1375.3" "1502.5" "6471.3" "4244.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "30" "22" "44" "22" "806" "89.3" "5.26" "8517.02" "69.91" "22" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf09336, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; hsa:7415; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5" "Neutrophil degranulation; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Aggrephagy; HSF1 activation; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Neddylation; KEAP1-NFE2L2 pathway; RHOH GTPase cycle; E3 ubiquitin ligases ubiquitinate target proteins; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism" "20" "0" "1629.1" "1542.6" "2272.9" "9272.8" "3462.9" "1464.4" "2879.3" "1793.4" "2213.4" "4975.1" "3867.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "45" "16" "35" "14" "281" "31.1" "5.01" "6969.00" "69.70" "12" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Eukaryotic Translation Elongation" "Translation factors" "2" "2" "1585.7" "1355.4" "1970.1" "5569.0" "2515.6" "1400.7" "2903.7" "1401.7" "1816.4" "4526.7" "3213.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P39023" "60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "42" "22" "46" "22" "403" "46.1" "10.18" "8080.31" "69.18" "19" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "6212.4" "4997.9" "6245.6" "14053.3" "7325.0" "4779.1" "11134.0" "4272.5" "5241.8" "14694.8" "8207.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "19" "22" "41" "22" "1224" "138.3" "7.66" "7095.51" "68.92" "19" "20" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957, Pf12894" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "" "2" "0" "1399.0" "1363.0" "1786.0" "3846.1" "2090.8" "1519.6" "2926.7" "1447.2" "1670.2" "5536.0" "4191.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "38" "22" "43" "22" "589" "66.1" "6.84" "7847.71" "68.73" "19" "18" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "Cytosolic tRNA aminoacylation" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "3" "0" "2290.2" "2022.9" "2678.4" "5040.1" "3005.6" "2274.5" "5209.1" "2262.1" "2743.4" "7308.0" "4645.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60709" "Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1" "38" "13" "36" "3" "375" "41.7" "5.48" "7448.87" "68.56" "11" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "60" "ENSG00000075624" "ACTB" "hsa:60; P02570; P60709; P70514; P99021; Q11211; Q64316; Q75MN2; Q96B34; Q96HG5" "RHO GTPases Activate Formins; UCH proteinases; Translocation of SLC2A4 (GLUT4) to the plasma membrane; B-WICH complex positively regulates rRNA expression; HATs acetylate histones; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RHOF GTPase cycle; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by RAF1 mutants; Adherens junctions interactions; DNA Damage Recognition in GG-NER; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions" "Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway" "47" "13" "1199.8" "1334.6" "2126.4" "13415.4" "3729.0" "552.3" "1199.6" "1744.3" "1089.6" "1949.9" "2354.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "24" "15" "36" "15" "623" "67.8" "7.66" "6479.95" "68.36" "11" "13" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "7" "0" "1106.8" "1078.3" "1817.5" "7895.4" "2981.1" "853.1" "1933.4" "1456.8" "1762.4" "3328.9" "3477.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "35" "17" "38" "17" "509" "57.4" "5.88" "6697.29" "68.34" "14" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Cytosolic tRNA aminoacylation" "Allograft rejection" "2" "0" "559.8" "495.8" "673.7" "1713.0" "859.6" "564.2" "1021.5" "634.5" "1633.6" "9001.0" "12067.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "49" "14" "41" "12" "255" "29.2" "4.74" "8995.88" "68.14" "13" "13" "stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of HSF1-mediated heat shock response; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; HSF1 activation; NADE modulates death signalling; Activation of BAD and translocation to mitochondria" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "25" "4" "1168.4" "1090.7" "1732.7" "9895.9" "2606.9" "737.2" "2608.8" "1593.4" "2044.1" "10984.3" "8368.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00159" "Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4" "17" "16" "36" "15" "1063" "121.6" "9.41" "6629.47" "67.60" "15" "16" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4641" "ENSG00000197879" "MYO1C" "hsa:4641; O00159; Q4LE56; Q6NVJ7; Q86Y95" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane" "VEGFA-VEGFR2 signaling; Insulin signaling" "7" "1" "337.3" "287.5" "413.1" "1089.9" "576.8" "426.6" "784.2" "765.0" "1959.3" "7651.3" "5819.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "21" "16" "41" "7" "590" "62.3" "7.74" "7266.68" "66.98" "15" "16" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "Formation of the cornified envelope; Type I hemidesmosome assembly" "" "3" "1" "2377.6" "2470.8" "994.8" "363.2" "365.1" "293.4" "1075.1" "160.7" "227.2" "520.2" "501.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "20" "14" "34" "14" "599" "67.3" "8.34" "6443.36" "66.70" "12" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "Interferon alpha/beta signaling; OAS antiviral response" "" "2" "0" "1057.3" "934.6" "1280.1" "3168.8" "1725.2" "1167.0" "2237.9" "1032.6" "1667.0" "5650.0" "5660.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "52" "10" "38" "10" "149" "16.8" "4.22" "7223.45" "66.64" "9" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "17" "0" "777.1" "659.1" "888.2" "3404.1" "1168.2" "532.8" "1104.5" "807.6" "1644.2" "9261.1" "9074.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q05397" "Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2" "19" "16" "31" "16" "1052" "119.2" "6.62" "5653.05" "66.44" "12" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038" "5747" "ENSG00000169398" "PTK2" "B4E2N6; F5H4S4; hsa:5747; J3QT16; Q05397; Q14291; Q8IYN9; Q9UD85" "RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Signal regulatory protein family interactions; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; MET activates PTK2 signaling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Apoptotic cleavage of cellular proteins" "Androgen receptor signaling pathway; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Hippo-Merlin signaling dysregulation; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Small cell lung cancer; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q13 copy number variation syndrome; TROP2 regulatory signaling; A network map of Macrophage-stimulating protein (MSP) signaling; ErbB signaling pathway" "48" "0" "435.1" "400.1" "513.3" "1238.1" "742.3" "562.2" "1229.4" "1748.7" "3945.9" "10860.6" "7735.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "41" "18" "38" "18" "434" "47.1" "7.39" "7637.40" "66.43" "16" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis" "8" "0" "1737.0" "1696.3" "2790.8" "16015.9" "4895.6" "783.3" "1583.2" "1820.9" "1434.2" "2908.5" "2995.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "30" "17" "32" "17" "548" "59.6" "5.60" "6375.10" "65.60" "14" "14" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "903.9" "878.2" "1188.2" "4527.3" "1756.5" "844.9" "1742.9" "972.3" "1101.0" "3871.5" "3620.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "64" "12" "39" "12" "165" "18.0" "7.81" "8292.14" "65.47" "10" "10" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "Prolactin signaling pathway" "16" "0" "1726.9" "1778.8" "2830.7" "14055.7" "4325.1" "1136.9" "2502.6" "2352.3" "1753.4" "3964.6" "3558.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "36" "12" "30" "12" "307" "34.9" "9.57" "4713.26" "65.36" "9" "10" "" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "" "VEGFA-VEGFR2 signaling" "1" "0" "1398.9" "1216.3" "1438.5" "3158.4" "1755.2" "1385.2" "2389.0" "1177.5" "1788.8" "5753.9" "5565.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02878" "60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "45" "16" "43" "16" "288" "32.7" "10.58" "7983.77" "65.16" "15" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "6130.9" "4978.8" "5928.1" "11466.1" "6388.3" "4670.4" "10019.2" "4067.3" "4839.5" "11427.5" "5731.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "19" "20" "37" "19" "1047" "119.8" "5.66" "6498.89" "65.05" "17" "18" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "" "12" "1" "1330.9" "1082.1" "1533.8" "4682.3" "2034.4" "1189.0" "2081.5" "1424.6" "2049.4" "8139.1" "9298.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62913" "60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "45" "11" "34" "11" "178" "20.2" "9.60" "6274.87" "64.58" "8" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "GTP hydrolysis and joining of the 60S ribosomal subunit; L13a-mediated translational silencing of Ceruloplasmin expression; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "2216.2" "2006.4" "2709.2" "5381.6" "3162.5" "2461.9" "5073.1" "2023.2" "2357.2" "5847.2" "3417.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=3" "28" "23" "42" "23" "935" "101.5" "7.30" "8028.91" "64.34" "19" "18" "" "" "" "" "" "" "" "" "" "" "0" "0" "2031.3" "1737.3" "2298.7" "6044.1" "2946.9" "1705.8" "3451.8" "1812.1" "2159.9" "5945.9" "4560.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "16" "16" "33" "16" "913" "105.3" "5.68" "7347.76" "64.32" "15" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "1304.3" "1254.9" "1583.3" "3837.5" "1961.2" "1440.9" "2740.3" "1343.8" "1531.4" "3996.4" "2797.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "22" "20" "36" "20" "1101" "120.8" "7.33" "7142.21" "64.31" "17" "17" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "10" "0" "1410.6" "1352.9" "1846.8" "5020.7" "2418.0" "1443.7" "2969.8" "1420.1" "1642.5" "5237.5" "4045.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08708" "40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "64" "10" "21" "10" "135" "15.5" "9.85" "2870.65" "63.43" "7" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1050.0" "945.9" "1061.9" "2227.4" "1272.0" "947.7" "1837.6" "1092.1" "1269.0" "3047.8" "2123.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62753" "40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "42" "15" "37" "15" "249" "28.7" "10.84" "8223.24" "63.34" "15" "11" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Nuclear events stimulated by ALK signaling in cancer; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; A network map of Macrophage-stimulating protein (MSP) signaling; Interferon type I signaling pathways" "47" "0" "3531.6" "2896.2" "3317.1" "6296.3" "3765.9" "2958.8" "5757.8" "2711.4" "2971.2" "6641.4" "4197.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62424" "60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "52" "18" "37" "18" "266" "30.0" "10.61" "7950.84" "62.71" "14" "13" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "3677.5" "3185.2" "4050.5" "8790.5" "4578.4" "3199.1" "6971.3" "2779.0" "3558.7" "8279.4" "4228.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "30" "15" "32" "15" "535" "57.5" "6.46" "6397.33" "62.62" "13" "12" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC; BBSome-mediated cargo-targeting to cilium; RHOBTB1 GTPase cycle" "16p11.2 proximal deletion syndrome" "10" "0" "640.9" "627.2" "782.0" "3125.0" "1191.8" "527.3" "1202.9" "695.8" "714.6" "2413.6" "2235.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "23" "15" "28" "15" "802" "92.2" "8.18" "4743.64" "62.58" "11" "13" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "mRNA Splicing - Major Pathway" "" "1" "0" "598.8" "559.3" "702.7" "1691.0" "895.9" "640.1" "1122.2" "600.5" "1052.8" "7845.5" "8472.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L576" "Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1" "12" "14" "39" "8" "1253" "145.1" "6.90" "7859.77" "62.45" "14" "12" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf05994, Pf07159" "23191" "ENSG00000273749; ENSG00000288461" "CYFIP1" "A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway" "15" "10" "674.7" "548.7" "745.7" "1328.0" "851.1" "706.1" "1336.1" "619.7" "1093.4" "3877.1" "3674.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P32969" "60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1" "52" "8" "31" "8" "192" "21.9" "9.95" "6269.40" "61.83" "6" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1053.0" "1097.4" "1246.8" "2452.3" "1419.0" "1070.0" "2213.0" "1196.8" "1137.8" "3035.4" "2042.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63104" "14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 GN=YWHAZ PE=1 SV=1" "47" "11" "32" "8" "245" "27.7" "4.79" "7173.85" "61.33" "11" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "7534" "ENSG00000164924" "YWHAZ" "A8K1N0; B7Z465; hsa:7534; P29213; P29312; P63104; Q32P43; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33" "RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Negative regulation of NOTCH4 signaling; Deactivation of the beta-catenin transactivating complex; Interleukin-3, Interleukin-5 and GM-CSF signaling; TP53 Regulates Metabolic Genes; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; Activation of BAD and translocation to mitochondria" "Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "23" "0" "494.1" "539.2" "989.3" "5430.4" "1586.0" "350.0" "1435.3" "837.9" "1115.8" "3412.3" "2391.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15344" "E3 ubiquitin-protein ligase Midline-1 OS=Homo sapiens OX=9606 GN=MID1 PE=1 SV=1" "22" "12" "25" "11" "667" "75.2" "6.80" "4603.44" "61.08" "10" "12" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00041, Pf00622, Pf00643, Pf13445, Pf13765, Pf18568" "4281" "ENSG00000101871" "MID1" "B2RCG2; hsa:4281; O15344; O75361; Q9BZX5" "Interferon gamma signaling" "" "1" "2" "423.2" "369.4" "478.1" "1028.8" "593.2" "473.5" "856.2" "516.5" "1194.0" "6078.8" "5641.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "23" "22" "39" "22" "825" "90.5" "6.00" "7511.66" "61.00" "17" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "4" "0" "2400.7" "2148.4" "2929.1" "8450.1" "3817.6" "2244.8" "4410.6" "1986.5" "2246.7" "5857.9" "3377.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "29" "12" "35" "12" "390" "43.3" "8.06" "7184.78" "60.90" "11" "12" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis" "14" "0" "1664.1" "1637.5" "2275.4" "4610.3" "2708.5" "1887.4" "4893.7" "1918.6" "2026.4" "5910.4" "2977.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P39019" "40S ribosomal protein S19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "69" "15" "37" "15" "145" "16.1" "10.32" "8049.34" "60.88" "14" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Complement system; Cytoplasmic ribosomal proteins" "20" "0" "2669.9" "2467.1" "2990.4" "5726.4" "3629.9" "2983.5" "6011.8" "2690.1" "3040.9" "6035.2" "4060.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05388" "60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "44" "13" "32" "13" "317" "34.3" "5.97" "6406.40" "60.46" "12" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "1278.6" "1318.5" "1708.9" "4496.2" "2179.7" "1288.4" "2912.8" "1317.6" "1482.7" "5493.2" "3301.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6WKZ4" "Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3" "17" "15" "31" "13" "1283" "137.1" "5.43" "6053.94" "60.14" "11" "14" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf09457" "80223" "ENSG00000156675" "RAB11FIP1" "hsa:80223; J3KNP0; Q307T1; Q6AZK4; Q6WKZ2; Q6WKZ4; Q6WKZ6; Q86YV4; Q8TDL1; Q9H642" "" "" "0" "2" "387.7" "298.0" "484.5" "991.0" "664.3" "508.6" "915.5" "850.1" "2207.4" "6093.2" "4330.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "27" "16" "30" "16" "804" "91.8" "7.42" "4943.37" "59.44" "13" "16" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "551.9" "529.3" "712.5" "1467.2" "842.6" "668.9" "1245.6" "745.1" "1004.3" "3640.2" "3708.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "40" "14" "31" "14" "406" "46.2" "5.83" "6189.90" "59.40" "13" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "Ciliary landscape" "6" "0" "393.3" "359.9" "505.9" "1523.8" "722.5" "512.4" "1502.6" "802.4" "997.5" "6793.8" "9821.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96N67" "Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4" "9" "14" "30" "13" "2140" "242.4" "6.80" "4667.08" "59.06" "10" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "85440" "ENSG00000116641" "DOCK7" "hsa:85440; Q00M63; Q2PPY7; Q45RE8; Q45RE9; Q5T1B9; Q5T1C0; Q6ZV32; Q8TB82; Q96N67; Q96NG6; Q96NI0; Q9C092" "RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; MET activates RAP1 and RAC1" "" "4" "1" "518.7" "483.6" "625.8" "1692.8" "798.0" "601.1" "1177.9" "779.3" "1155.7" "5145.3" "5966.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62280" "40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "57" "14" "35" "14" "158" "18.4" "10.30" "6107.33" "58.95" "12" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "21" "0" "2771.7" "2302.5" "2719.4" "5524.8" "3227.2" "2338.2" "4541.9" "2172.0" "2383.6" "6267.4" "4377.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "63" "9" "35" "9" "131" "13.8" "9.77" "6705.80" "58.74" "6" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "2771.3" "2041.4" "2567.8" "3921.6" "3071.3" "2120.6" "3967.9" "2164.4" "3003.8" "6082.3" "4085.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "20" "14" "29" "14" "944" "106.8" "6.14" "4531.58" "58.38" "11" "14" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "N-glycan biosynthesis" "5" "0" "609.9" "513.0" "887.8" "2911.6" "1223.6" "649.0" "1206.3" "739.7" "796.6" "2457.1" "2106.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "11" "15" "35" "15" "1675" "191.5" "5.69" "6789.34" "58.27" "15" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "ALK mutants bind TKIs; Nuclear events stimulated by ALK signaling in cancer; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; RHOU GTPase cycle; LDL clearance; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "25" "0" "925.6" "990.1" "1345.0" "5560.9" "1955.1" "894.1" "1947.1" "1172.5" "1288.0" "4416.8" "3162.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P57772" "Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4" "22" "13" "32" "13" "596" "65.3" "8.35" "6969.19" "57.93" "13" "11" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009" "60678" "ENSG00000132394; ENSG00000284869" "EEFSEC" "hsa:60678; P57772; Q96HZ6" "Selenocysteine synthesis" "" "1" "0" "438.0" "379.6" "498.0" "1288.2" "695.3" "493.1" "1101.7" "1339.7" "3725.1" "9418.6" "6393.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "12" "15" "30" "15" "1616" "183.1" "7.75" "5831.64" "57.85" "13" "14" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency" "10" "0" "1327.7" "943.5" "1247.7" "2406.8" "1580.1" "1256.6" "2081.5" "741.6" "1223.4" "3256.3" "2286.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62263" "40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "46" "8" "22" "8" "151" "16.3" "10.05" "3587.18" "57.81" "6" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "913.6" "783.1" "1014.6" "1871.8" "1255.4" "1010.7" "1822.9" "829.7" "941.7" "1763.9" "1146.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63244" "Receptor of activated protein C kinase 1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "59" "15" "32" "15" "317" "35.1" "7.69" "5262.66" "57.60" "12" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "10" "0" "798.6" "794.4" "1060.8" "3243.9" "1439.3" "890.9" "2070.2" "881.0" "1003.4" "4781.4" "3555.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "32" "13" "31" "13" "443" "51.6" "5.53" "5874.47" "57.41" "12" "12" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Neddylation; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle" "Ciliary landscape" "6" "0" "197.2" "174.2" "259.0" "762.1" "405.0" "311.6" "1035.7" "578.0" "736.1" "4757.8" "7785.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y606" "tRNA pseudouridine synthase A OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "35" "14" "31" "14" "427" "47.4" "8.41" "4848.48" "57.18" "11" "13" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "500.2" "438.1" "668.2" "1332.9" "809.5" "571.1" "914.1" "595.2" "1132.0" "5775.1" "8593.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62249" "40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "62" "14" "36" "14" "146" "16.4" "10.21" "6990.99" "57.06" "12" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "2214.8" "1881.2" "2246.8" "3825.6" "2568.0" "1964.2" "3259.8" "1917.4" "2284.7" "4253.8" "3253.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "58" "14" "32" "10" "199" "22.1" "8.13" "5494.30" "56.74" "12" "12" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway" "8" "5" "1049.3" "951.5" "1399.1" "8622.0" "2158.9" "747.7" "1683.8" "1052.0" "1076.1" "3517.8" "2942.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "51" "12" "26" "12" "253" "29.8" "9.06" "3931.84" "56.68" "9" "12" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698; ENSG00000285317" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "918.5" "715.5" "1125.6" "2813.5" "1538.7" "888.2" "1812.3" "806.3" "1950.1" "11711.9" "13250.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62269" "40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "47" "13" "40" "13" "152" "17.7" "10.99" "7837.04" "56.59" "13" "11" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "2515.5" "2225.7" "2341.1" "6053.6" "3289.2" "2229.2" "4590.5" "2282.8" "2384.7" "7164.7" "4868.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "8" "10" "28" "10" "1824" "206.7" "6.47" "5121.77" "56.33" "9" "10" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "hsa:4301; O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "3" "0" "375.6" "342.5" "438.7" "1190.2" "555.7" "379.9" "579.3" "388.1" "1121.7" "6517.0" "7229.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62241" "40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "57" "12" "32" "11" "208" "24.2" "10.32" "4719.17" "55.76" "10" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "1" "1375.3" "1222.0" "1329.7" "3034.0" "1750.7" "1238.4" "2525.4" "1348.9" "1336.7" "3454.7" "2683.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "8" "15" "32" "15" "2335" "273.4" "8.84" "5305.25" "55.73" "13" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "698.8" "630.3" "799.7" "2159.5" "1095.1" "705.5" "1354.2" "705.6" "853.6" "4322.7" "4227.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "49" "11" "31" "5" "246" "28.1" "4.83" "6305.86" "55.40" "10" "9" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "TP53 Regulates Metabolic Genes; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by BRAF and RAF1 fusions; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "33" "4" "721.2" "675.8" "938.4" "3171.8" "1230.4" "509.6" "1445.4" "848.0" "1117.7" "2802.1" "1886.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "18" "11" "27" "11" "764" "89.4" "5.81" "5946.25" "55.25" "11" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "Ectoderm differentiation" "6" "0" "346.2" "332.9" "424.4" "1178.4" "580.5" "371.7" "854.8" "448.9" "995.0" "7406.1" "6239.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "31" "12" "27" "12" "505" "56.7" "6.35" "5359.48" "55.25" "11" "12" "cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "Prion disease pathway" "4" "0" "984.5" "938.4" "1408.1" "4407.1" "2020.5" "1005.0" "1855.2" "1181.5" "1489.3" "2933.8" "2191.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "34" "14" "34" "12" "355" "38.4" "7.81" "6646.26" "55.15" "12" "12" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "2" "2209.8" "1891.7" "2568.7" "6760.0" "3270.1" "2090.9" "4253.8" "1627.5" "1969.2" "5424.8" "2766.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "29" "10" "22" "9" "546" "61.9" "6.52" "3814.39" "54.86" "7" "9" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "Other interleukin signaling" "" "1" "0" "114.2" "78.6" "115.4" "350.9" "156.7" "99.2" "182.8" "115.4" "180.6" "1548.8" "1758.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "28" "12" "27" "12" "463" "50.9" "5.54" "5840.10" "54.52" "11" "10" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "mRNA Splicing - Major Pathway; HCMV Late Events; SUMOylation of RNA binding proteins; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "6" "0" "1161.2" "999.7" "1393.0" "5238.0" "2091.0" "983.5" "1810.0" "1090.0" "1173.7" "3010.9" "2349.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "12" "18" "32" "14" "1960" "226.4" "5.60" "7613.36" "54.43" "17" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome" "16" "4" "1005.4" "954.1" "1359.6" "5791.0" "2257.3" "939.9" "1390.0" "1025.9" "1135.2" "2599.6" "2271.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "24" "11" "28" "11" "585" "64.9" "8.87" "6598.66" "54.41" "11" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "0" "858.9" "640.4" "875.3" "1764.2" "1134.6" "812.5" "1330.2" "661.9" "1236.6" "5615.3" "6813.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96G61" "Diphosphoinositol polyphosphate phosphohydrolase 3-beta OS=Homo sapiens OX=9606 GN=NUDT11 PE=1 SV=1" "64" "12" "24" "1" "164" "18.5" "5.99" "4190.17" "54.31" "9" "10" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "55190" "ENSG00000196368" "NUDT11" "hsa:55190; Q96G61; Q9NVN0" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "16.7" "17.4" "28.4" "73.9" "42.2" "41.7" "108.5" "147.3" "296.5" "708.9" "614.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "44" "15" "42" "15" "301" "33.9" "8.38" "8132.55" "54.23" "14" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "15" "0" "640.6" "541.8" "867.5" "1723.5" "1030.5" "683.8" "1316.8" "743.6" "1701.1" "7579.5" "9244.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=3" "44" "14" "30" "14" "286" "30.8" "5.92" "6555.72" "54.18" "13" "11" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "" "ENSPPYG00000004207; ENSPTRG00000004595" "TPI1" "A0A2J8JEI5; A0A2J8JEJ3; A0A2J8TBG7; A0A6D2X563; H2NGA4" "" "" "0" "0" "1221.0" "1295.5" "2116.0" "12971.8" "3644.6" "574.3" "1204.6" "1388.2" "1011.3" "2237.3" "2594.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "36" "14" "34" "14" "408" "46.8" "7.12" "6639.17" "53.97" "14" "12" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "" "2" "0" "1068.4" "974.0" "1361.2" "7019.8" "2109.6" "838.6" "1606.4" "1070.9" "1224.7" "4849.8" "4639.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "22" "11" "26" "11" "576" "60.3" "4.83" "4418.25" "53.83" "9" "10" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417, Pf02809" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "5" "0" "412.3" "314.7" "425.5" "1027.8" "711.6" "607.1" "1727.6" "1893.2" "2803.2" "7182.9" "5282.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50914" "60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "42" "13" "32" "13" "215" "23.4" "10.93" "5685.33" "53.73" "11" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "3065.2" "2671.8" "3151.0" "7010.4" "3763.6" "2471.0" "5614.1" "2565.6" "2758.2" "6803.0" "3756.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43175" "D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4" "26" "11" "24" "11" "533" "56.6" "6.71" "4932.03" "53.61" "9" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00389, Pf02826, Pf19304" "26227" "ENSG00000092621" "PHGDH" "B2RD08; hsa:26227; O43175; Q5SZU3; Q9BQ01" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "5" "0" "725.1" "685.6" "971.9" "4256.2" "1584.8" "665.8" "1530.9" "1101.9" "976.0" "2956.4" "2696.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61313" "60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "36" "8" "27" "8" "204" "24.1" "11.62" "5271.64" "53.33" "8" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1309.8" "1295.4" "1554.7" "3633.1" "1872.7" "1273.2" "2839.6" "1362.7" "1559.0" "3985.4" "2091.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "54" "8" "27" "8" "151" "16.9" "4.65" "5634.99" "53.32" "8" "7" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "Smooth Muscle Contraction; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Ciliary landscape" "8" "0" "549.1" "546.2" "666.2" "2489.8" "974.9" "438.2" "717.3" "495.0" "804.9" "6739.7" "7567.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08133" "Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3" "22" "13" "26" "13" "673" "75.8" "5.60" "4447.45" "52.98" "9" "13" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00191" "309" "ENSG00000197043" "ANXA6" "B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79" "Smooth Muscle Contraction" "Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation" "3" "0" "264.6" "257.8" "358.8" "1081.0" "492.7" "307.8" "509.4" "325.2" "486.2" "4400.2" "8122.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "23" "12" "23" "12" "750" "83.1" "6.93" "3844.13" "52.96" "8" "12" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "Vitamin B12 metabolism; Amino acid metabolism" "6" "0" "274.8" "249.2" "349.7" "1039.5" "478.6" "313.3" "522.5" "328.3" "732.8" "4248.5" "4750.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NFP7" "Diphosphoinositol polyphosphate phosphohydrolase 3-alpha OS=Homo sapiens OX=9606 GN=NUDT10 PE=1 SV=1" "64" "12" "24" "1" "164" "18.5" "5.68" "4009.96" "52.92" "9" "10" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "170685" "ENSG00000122824" "NUDT10" "A8K7D7; D3DX69; hsa:170685; Q86VK1; Q86VR0; Q8NFP7" "Synthesis of pyrophosphates in the cytosol" "" "1" "12" "233.0" "236.2" "324.0" "833.3" "594.2" "642.5" "2010.3" "2205.3" "3877.4" "8190.9" "7193.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2A7" "Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1" "12" "13" "27" "13" "1128" "128.7" "6.62" "4192.08" "52.92" "10" "12" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf09735" "10787" "ENSG00000061676" "NCKAP1" "hsa:10787; O60329; Q53QN5; Q53S94; Q53Y35; Q9Y2A7" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Exercise-induced circadian regulation; Regulation of actin cytoskeleton" "9" "0" "1092.6" "1041.2" "1278.5" "2380.4" "1430.3" "1166.9" "2285.0" "1052.2" "1816.7" "5800.6" "5481.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62736" "Actin, aortic smooth muscle OS=Homo sapiens OX=9606 GN=ACTA2 PE=1 SV=1" "25" "11" "35" "1" "377" "42.0" "5.39" "7268.54" "52.79" "11" "9" "developmental processes;other biological processes" "extracellular matrix;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "59" "ENSG00000107796" "ACTA2" "B2R8A4; hsa:59; P03996; P04108; P62736; Q6FI19" "Smooth Muscle Contraction; NOTCH4 Intracellular Domain Regulates Transcription" "Myometrial relaxation and contraction pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; Urotensin-II-mediated signaling pathway; Markers of kidney cell lineage; Comprehensive IL-17A signaling; IL-26 signaling pathways; A network map of Macrophage-stimulating protein (MSP) signaling" "16" "0" "202.4" "212.2" "348.0" "2770.4" "757.5" "125.4" "288.5" "279.3" "240.5" "573.5" "671.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P83731" "60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "43" "9" "39" "9" "157" "17.8" "11.25" "8923.00" "51.97" "9" "7" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "3500.5" "3128.7" "3584.5" "6961.2" "4145.0" "3053.8" "6334.0" "2728.8" "3060.8" "7590.3" "4339.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "57" "10" "24" "10" "148" "17.2" "9.60" "4586.11" "51.93" "8" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "Transcriptional activation of mitochondrial biogenesis" "" "1" "0" "1083.5" "1031.2" "1571.0" "3347.4" "1742.1" "959.7" "2033.1" "1127.5" "1283.1" "3206.6" "2330.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "35" "12" "26" "11" "386" "43.8" "7.20" "5611.90" "51.76" "11" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "Network map of SARS-CoV-2 signaling pathway" "3" "0" "343.5" "293.2" "426.2" "957.7" "550.2" "435.0" "993.0" "804.1" "1516.9" "5809.4" "5708.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "74" "12" "25" "12" "189" "19.9" "6.79" "4655.88" "51.61" "9" "11" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway" "7" "0" "1619.0" "1403.0" "1905.2" "3582.5" "2149.2" "1465.3" "4205.2" "1356.2" "1552.9" "5430.5" "2202.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=2" "12" "14" "27" "14" "1268" "141.4" "6.87" "5085.90" "51.50" "13" "13" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "HDL clearance" "2q37 copy number variation syndrome" "2" "0" "704.1" "621.0" "758.4" "1883.5" "1007.8" "710.8" "1399.9" "626.5" "786.2" "2625.1" "1964.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96KP1" "Exocyst complex component 2 OS=Homo sapiens OX=9606 GN=EXOC2 PE=1 SV=1" "15" "13" "27" "13" "924" "104.0" "6.90" "5198.23" "51.34" "12" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01833, Pf15469" "55770" "ENSG00000112685" "EXOC2" "B2RBE6; hsa:55770; Q5JPC8; Q96AN6; Q96KP1; Q9NUZ8; Q9UJM7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Ciliary landscape" "7" "0" "319.4" "277.0" "407.1" "1043.3" "535.1" "375.6" "627.5" "480.9" "1370.8" "6647.5" "5384.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "40" "10" "25" "10" "312" "34.3" "8.43" "4690.71" "51.28" "10" "10" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Ciliary landscape" "3" "0" "385.9" "381.6" "517.6" "2132.4" "767.4" "368.0" "737.6" "506.0" "799.1" "4252.7" "5891.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "44" "14" "25" "13" "320" "33.6" "7.77" "5217.10" "51.23" "12" "12" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Glutamate and glutamine metabolism" "Metabolic reprogramming in colon cancer" "2" "1" "1134.6" "936.9" "1336.3" "2811.8" "1637.5" "1215.2" "2215.3" "1062.4" "1376.7" "3390.4" "2296.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "52" "10" "22" "7" "324" "35.9" "9.88" "3922.52" "51.18" "7" "8" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Processing of Capped Intron-Containing Pre-mRNA; Interferon gamma signaling; Noncanonical activation of NOTCH3" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "10" "4" "640.5" "560.6" "622.1" "1416.4" "794.2" "543.2" "965.1" "494.7" "571.7" "1254.9" "958.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "34" "14" "26" "14" "556" "60.3" "6.11" "4669.30" "50.94" "12" "12" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "599.5" "637.5" "849.6" "3475.3" "1304.1" "516.7" "1338.1" "695.8" "875.8" "2874.5" "2579.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "23" "13" "28" "7" "644" "70.7" "9.26" "5070.62" "50.50" "13" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "807.0" "704.2" "924.4" "2788.7" "1276.0" "732.7" "1708.1" "772.4" "911.4" "2621.8" "1717.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "53" "7" "25" "7" "154" "16.8" "5.24" "3296.89" "50.48" "5" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Hypusine synthesis from eIF5A-lysine" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "3" "0" "828.8" "614.6" "1018.9" "2561.3" "1350.8" "668.9" "1336.1" "728.0" "992.0" "5823.1" "15809.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "39" "9" "25" "9" "303" "33.8" "6.74" "4487.12" "50.19" "8" "9" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; A network map of Macrophage-stimulating protein (MSP) signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "21" "0" "918.4" "754.7" "955.2" "1669.6" "1053.3" "734.0" "2437.4" "693.5" "898.1" "2863.1" "1251.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P21108" "Ribose-phosphate pyrophosphokinase 3 OS=Homo sapiens OX=9606 GN=PRPS1L1 PE=1 SV=2" "26" "7" "25" "1" "318" "34.8" "6.35" "3467.69" "50.06" "6" "6" "other metabolic processes;developmental processes" "other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "221823" "ENSG00000229937" "PRPS1L1" "hsa:221823; P21108; Q6P5P6" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "18" "7" "25" "7" "443" "48.2" "8.66" "5103.58" "49.98" "7" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "PTK6 Regulates Proteins Involved in RNA Processing" "Leptin signaling pathway; Primary ovarian insufficiency" "3" "0" "1013.2" "998.9" "1151.5" "2269.0" "1418.1" "1111.9" "2285.1" "1301.5" "1488.9" "3000.4" "2124.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "15" "12" "26" "12" "974" "110.4" "6.49" "4883.75" "49.97" "10" "12" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "272.6" "239.2" "326.1" "760.4" "402.0" "282.3" "521.0" "404.5" "1019.3" "4695.3" "3691.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "44" "12" "25" "11" "369" "40.9" "7.44" "4274.69" "49.65" "10" "11" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "1" "347.4" "328.7" "417.0" "1210.2" "561.8" "413.7" "686.3" "461.5" "976.9" "4683.2" "5767.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12277" "Creatine kinase B-type OS=Homo sapiens OX=9606 GN=CKB PE=1 SV=1" "27" "8" "18" "8" "381" "42.6" "5.59" "2128.72" "49.58" "4" "8" "other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00217, Pf02807" "1152" "ENSG00000166165" "CKB" "A8K236; B2R5R4; hsa:1152; P12277; Q2LE07; Q6FG40; Q9UC66" "RND3 GTPase cycle; Creatine metabolism" "" "2" "0" "318.4" "408.7" "635.4" "3972.6" "1166.8" "199.4" "388.5" "499.6" "338.2" "766.1" "980.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "26" "18" "35" "18" "730" "77.5" "8.70" "7669.92" "49.51" "17" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "4" "0" "1504.1" "1455.2" "1913.8" "5800.4" "2608.4" "1353.9" "3049.8" "1675.8" "1824.8" "6872.4" "6854.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "22" "8" "22" "8" "548" "63.9" "6.05" "3892.49" "49.28" "5" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "476.0" "468.5" "630.1" "1886.6" "844.0" "559.3" "1098.0" "506.1" "675.3" "1966.4" "1138.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "9" "14" "26" "14" "2005" "226.2" "7.30" "4958.35" "49.00" "12" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; hsa:23347; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "830.4" "756.2" "1025.5" "2525.7" "1316.5" "870.9" "1553.9" "813.2" "1043.1" "2754.9" "1945.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q05639" "Elongation factor 1-alpha 2 OS=Homo sapiens OX=9606 GN=EEF1A2 PE=1 SV=1" "29" "12" "30" "1" "463" "50.4" "9.03" "5258.53" "48.89" "10" "11" "protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "1917" "ENSG00000101210" "EEF1A2" "B5BUF3; E1P5J1; hsa:1917; P54266; Q05639; Q0VGC7" "Eukaryotic Translation Elongation" "Translation factors" "2" "0" "19.4" "19.5" "23.4" "85.2" "39.7" "23.3" "43.3" "24.4" "27.9" "249.4" "386.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "17" "11" "22" "11" "900" "101.1" "6.16" "3785.30" "48.89" "9" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "" "2" "0" "513.0" "523.0" "715.5" "3048.4" "1184.6" "538.9" "1222.2" "699.3" "737.5" "2768.6" "3325.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30050" "60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "70" "11" "29" "11" "165" "17.8" "9.42" "5270.27" "48.61" "10" "10" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1590.7" "1408.7" "2108.4" "5795.9" "2820.0" "1356.9" "3607.9" "1601.9" "1686.4" "4995.2" "2812.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "5" "13" "28" "11" "2896" "316.7" "9.13" "4573.17" "48.59" "12" "13" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "" "VEGFA-VEGFR2 signaling" "1" "1" "1358.1" "987.4" "1306.5" "2158.0" "1549.0" "1059.1" "1759.4" "891.7" "1264.5" "1944.9" "1176.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "36" "8" "22" "8" "308" "33.8" "8.12" "3902.64" "48.50" "5" "8" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "844.8" "656.4" "818.3" "1456.4" "1016.9" "803.6" "832.1" "662.8" "849.9" "1370.5" "1334.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "21" "13" "29" "9" "644" "67.5" "7.61" "5733.27" "48.26" "13" "12" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "1" "757.1" "663.7" "1131.1" "3718.3" "1458.8" "634.5" "1788.2" "860.4" "1166.0" "3246.2" "2451.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "20" "13" "27" "13" "895" "100.2" "5.67" "4815.87" "48.07" "11" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1026.4" "840.2" "1220.6" "2812.9" "1541.8" "945.4" "1787.1" "844.0" "1068.7" "2514.3" "1793.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "39" "7" "21" "7" "241" "26.5" "8.13" "4220.58" "48.01" "6" "7" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "592.8" "549.0" "620.5" "1359.1" "751.7" "561.0" "786.1" "530.4" "689.8" "1720.5" "1432.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "17" "7" "22" "4" "526" "53.4" "9.36" "3670.42" "47.89" "5" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing" "4" "4" "1794.0" "1658.7" "1921.0" "4237.7" "2131.6" "1564.9" "3000.4" "1429.8" "1765.1" "5153.0" "3227.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "24" "13" "25" "13" "660" "75.3" "6.68" "5042.17" "47.85" "11" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "Amino acid metabolism" "3" "0" "378.5" "373.1" "532.5" "1971.6" "789.9" "364.8" "659.9" "473.1" "513.6" "2873.3" "6177.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62857" "40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "72" "7" "25" "7" "69" "7.8" "10.70" "5720.69" "47.51" "6" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1230.1" "1024.0" "1352.9" "2423.4" "1613.2" "1449.5" "2771.3" "1058.5" "1314.5" "3056.4" "2328.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "28" "9" "19" "9" "390" "43.0" "5.26" "3982.80" "47.25" "7" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07528" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "Neutrophil degranulation" "B cell receptor signaling pathway" "2" "0" "687.1" "603.7" "731.3" "2031.0" "1011.9" "588.0" "1259.6" "575.8" "720.4" "2346.9" "1521.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96AC1" "Fermitin family homolog 2 OS=Homo sapiens OX=9606 GN=FERMT2 PE=1 SV=1" "19" "10" "22" "10" "680" "77.8" "6.70" "4309.90" "47.04" "7" "9" "cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00169, Pf00373, Pf18124" "10979" "ENSG00000073712" "FERMT2" "B5TJY2; hsa:10979; Q14840; Q86TY7; Q96AC1" "RAC1 GTPase cycle; RAC3 GTPase cycle; Cell-extracellular matrix interactions" "" "3" "0" "126.2" "108.1" "172.6" "432.6" "272.8" "137.5" "236.7" "146.2" "257.1" "2134.3" "4487.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "21" "12" "22" "12" "585" "69.0" "5.87" "3211.59" "46.51" "8" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle" "" "3" "0" "295.2" "270.8" "341.6" "939.6" "451.4" "277.6" "477.3" "353.6" "769.5" "7181.8" "8862.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "16" "10" "25" "10" "775" "87.7" "7.15" "4860.13" "46.46" "9" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "3" "0" "359.3" "328.1" "427.5" "1245.5" "565.5" "341.3" "649.2" "353.6" "380.8" "1450.0" "1830.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "32" "12" "21" "12" "477" "53.2" "8.98" "3492.64" "46.35" "9" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Mitochondrial tRNA aminoacylation" "Orexin receptor pathway" "2" "0" "963.7" "809.0" "1084.3" "2171.1" "1209.6" "1171.4" "1982.7" "1152.1" "2302.5" "4813.1" "3580.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "24" "14" "33" "3" "472" "51.5" "5.16" "5950.78" "46.22" "12" "12" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Formation of the cornified envelope; Type I hemidesmosome assembly" "Corticotropin-releasing hormone signaling pathway" "4" "5" "4284.9" "3226.8" "1646.6" "1009.6" "706.1" "567.9" "1014.4" "379.5" "593.6" "1501.2" "1131.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "34" "9" "18" "9" "386" "43.2" "7.17" "3642.89" "46.18" "5" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "280.2" "266.4" "348.3" "843.3" "457.7" "324.0" "625.3" "375.7" "1061.2" "4630.3" "4639.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15880" "40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "42" "13" "33" "13" "293" "31.3" "10.24" "8077.97" "45.84" "13" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; RMTs methylate histone arginines; rRNA modification in the nucleus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Protein methylation; Peptide chain elongation; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "22" "0" "1683.1" "1561.6" "2052.0" "6337.7" "2612.2" "1415.6" "3675.5" "1962.4" "2386.0" "9490.0" "7194.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04843" "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1" "20" "9" "22" "9" "607" "68.5" "6.38" "3832.77" "45.78" "8" "9" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf04597" "6184" "ENSG00000163902" "RPN1" "B2R5Z0; D3DNB6; hsa:6184; P04843; Q68DT1" "SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein" "Proteasome degradation; N-glycan biosynthesis" "5" "0" "351.3" "341.1" "456.3" "1580.4" "615.2" "333.3" "602.3" "380.2" "434.4" "1573.3" "1639.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "34" "11" "29" "11" "328" "35.8" "8.00" "6067.97" "45.52" "9" "10" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Peroxisomal protein import" "Fatty acid biosynthesis; IL-18 signaling pathway" "3" "0" "928.6" "765.3" "1037.1" "1926.7" "1169.2" "899.2" "1871.2" "711.2" "1243.6" "4644.4" "3790.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "27" "13" "22" "13" "645" "72.9" "5.07" "4477.09" "45.28" "11" "11" "stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "0" "646.9" "657.5" "935.2" "3964.2" "1430.0" "557.0" "1001.8" "714.1" "850.5" "1846.3" "1544.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "6" "12" "25" "10" "2647" "280.6" "6.06" "4570.33" "45.22" "11" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome" "13" "2" "651.0" "639.1" "955.1" "3548.7" "1394.2" "620.4" "992.9" "687.0" "765.0" "1618.2" "1300.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "27" "12" "23" "12" "440" "48.1" "5.08" "4232.91" "44.99" "9" "11" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "5" "0" "1102.8" "912.3" "1283.4" "3046.3" "1636.1" "1078.2" "2838.5" "908.1" "1201.4" "2894.5" "1387.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62906" "60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "45" "11" "26" "11" "217" "24.8" "9.94" "7341.36" "44.96" "9" "9" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "1288.7" "1169.7" "1542.2" "3588.6" "1946.0" "1239.1" "2608.2" "1250.9" "1463.8" "3942.4" "2273.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q07065" "Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2" "23" "9" "18" "9" "602" "66.0" "5.92" "3567.78" "44.89" "7" "9" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "10970" "ENSG00000136026" "CKAP4" "hsa:10970; Q07065; Q504S5; Q53ES6" "Neutrophil degranulation; RND2 GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND3 GTPase cycle; Surfactant metabolism" "" "6" "0" "423.5" "397.0" "606.3" "1969.5" "849.9" "427.6" "1023.1" "567.4" "641.9" "1851.6" "1214.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "27" "11" "24" "11" "539" "57.9" "7.83" "4689.32" "44.83" "10" "10" "transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "968.4" "911.2" "1196.6" "4055.7" "1696.0" "837.4" "1761.7" "930.5" "910.4" "2826.1" "2532.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "27" "10" "17" "10" "527" "58.0" "6.43" "2829.47" "44.62" "5" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "0" "133.5" "147.4" "177.5" "538.7" "273.3" "188.5" "279.9" "176.7" "329.8" "3172.3" "5988.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99623" "Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2" "25" "7" "24" "7" "299" "33.3" "9.83" "5138.15" "44.19" "7" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01145" "11331" "ENSG00000215021" "PHB2" "B4DP75; hsa:11331; Q2YDA4; Q7KYU3; Q92978; Q99623" "Processing of SMDT1" "" "1" "0" "625.8" "696.3" "896.7" "3492.0" "1297.6" "615.2" "1063.2" "817.6" "807.3" "2049.7" "1950.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13797" "Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4" "21" "11" "24" "11" "630" "70.8" "5.60" "5003.81" "44.17" "10" "10" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf13499" "5358" "ENSG00000102024" "PLS3" "A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6" "" "" "0" "0" "449.8" "433.7" "769.0" "4492.7" "1389.3" "411.8" "1019.3" "655.0" "794.8" "2198.3" "1897.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "18" "8" "19" "8" "508" "57.5" "7.80" "3749.77" "44.01" "7" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "Cytosolic tRNA aminoacylation" "" "1" "0" "822.8" "747.7" "874.7" "1648.8" "1067.7" "781.9" "1484.0" "791.5" "906.0" "2113.6" "1446.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "10" "8" "20" "8" "835" "88.5" "5.77" "4209.38" "43.95" "6" "8" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "SUMOylation of transcription cofactors; Generic Transcription Pathway; HCMV Early Events" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "6" "0" "473.3" "510.6" "667.3" "2878.5" "1089.9" "457.4" "867.2" "548.8" "551.8" "1697.4" "1433.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P16152" "Carbonyl reductase [NADPH] 1 OS=Homo sapiens OX=9606 GN=CBR1 PE=1 SV=3" "37" "9" "22" "9" "277" "30.4" "8.32" "3937.89" "43.92" "7" "9" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00106" "873" "ENSG00000159228" "CBR1" "B2RBZ7; B4DFK7; hsa:873; P16152; Q3LHW8" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Nuclear receptors meta-pathway; NRF2 pathway; Prostaglandin synthesis and regulation" "4" "0" "542.9" "534.9" "748.4" "2040.8" "1009.2" "571.5" "1396.2" "692.1" "752.7" "2803.3" "3483.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27635" "60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4" "55" "12" "29" "12" "214" "24.6" "10.08" "5781.43" "43.74" "11" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "100137264; 100146244; 100172946; 100415355; 100468790; 100724614; 100982236; 101083663; 101136536; 101344695; 101444008; 101539056; 101690567; 101867181; 101975002; 102028809; 102257301; 102442647; 102878669; 102890423; 102923570; 102957760; 103127392; 103211225; 103250904; 103731218; 104667036; 104872587; 105294701; 105302495; 105467951; 105521640; 105579731; 105727260; 105824536; 105867804; 106000161; 107160308; 108513162; 108518769; 109696857; 110954; 465944; 700795; 81764" "ENSAMEG00000000227; ENSANAG00000036053; ENSCAFG00020009114; ENSCAFG00030015144; ENSCAFG00040021422; ENSCAFG00845028627; ENSCANG00000032226; ENSCATG00000030970; ENSCCAG00000024992; ENSCGRG00001008387; ENSCJAG00000011822; ENSCLAG00000003108; ENSCPOG00000002355; ENSECAG00000017154; ENSFCAG00000011395; ENSGGOG00000000131; ENSLCNG00005021252; ENSMFAG00000040824; ENSMLUG00000014337; ENSMMMG00000014279; ENSMMUG00000005494; ENSMNEG00000038094; ENSMPUG00000009320; ENSMUSG00000008682; ENSMUSG00000058443; ENSNGAG00000023746; ENSNLEG00000028143; ENSNVIG00000023818; ENSPANG00000008309; ENSPCOG00000027122; ENSPPAG00000034160; ENSPPYG00000020874; ENSPSMG00000015404; ENSPTIG00000005599; ENSPTRG00000043378; ENSRBIG00000042996; ENSRNOG00000056765; ENSRROG00000019247; ENSSSUG00005010590; ENSSTOG00000011857; ENSTGEG00000012563; ENSUAMG00000020454; ENSUMAG00000019583; ENSUPAG00010000252" "LOC100768740; LOC101344695; LOC105294701; LOC112632580; Rpl10; RPL10" "A0A091D943; A0A1S3APJ4; A0A1S3GPT7; A0A1U7SU42; A0A250YCK6; A0A286XQR8; A0A2I3FV08; A0A2J8IN69; A0A2J8RLU6; A0A2K5EV78; A0A2K5ILK8; A0A2K5LLF2; A0A2K5QER4; A0A2K5U275; A0A2K6D043; A0A2K6GRP4; A0A2K6MTH0; A0A2K6NK39; A0A2R9B361; A0A2Y9G5G6; A0A384DKX1; A0A3Q0CF07; A0A3Q7NJC4; A0A452S2Z9; A0A485PEW4; A0A667IJV2; A0A673U4F8; A0A6D2WIN2; A0A6D2XTB8; A0A6I9ME29; A0A6J0A9X4; A0A6J2E7G1; A0A6J3GU06; A0A6P3QFP2; A0A6P5P1X6; A0A6P6DLY1; A0A7J7YFN8; A0A7J8J7V5; A0A822A0T4; A0A8B7B976; A0A8B7FW91; A0A8C0K7J7; A0A8C0TBM4; A0A8C2LMI8; A0A8C2UVN1; A0A8C5ZPE8; A0A8C6S1T7; A0A8C7BXJ2; A0A8C8ZPD3; A0A8C9J452; A0A8D2F5T2; A0A8D2GF85; A0A8I3PXJ3; A0A8J8XDM4; A0A8M1M1S6; A0A9B0U593; A2AM97; A6KRS1; A9CB60; aju:106987320; aml:100468790; B0KWW6; B1MTV1; B3RFD9; C3PT02; cang:105521640; caty:105579731; ccan:109696857; cpoc:100724614; csyr:103250904; D3YC00; dnm:101444008; dord:106000161; ecb:100146244; F7AYR2; F7GKJ8; fca:101083663; G1PPT9; G2HFW2; G3S9Q9; G7Q3B3; ggo:101136536; H2PX84; I2CYS4; I3MI39; L5KDV0; L8Y8T7; M3WF14; M3YD39; mcal:110286529; mcc:700795; mcf:101867181; mlf:102442647; mmu:110954; mmur:105867804; mni:105467951; mpuf:101690567; myb:102257301; nsu:110578606; P45634; pale:102878669; pale:102890423; panu:100137264; pcoq:105824536; pps:100982236; ptg:102957760; ptr:465944; pvp:105294701; pvp:105302495; Q569M8; Q5M9K8; Q6PDV7; Q6ZWV3; rbb:108513162; rbb:108518769; rno:81764; rro:104667036; S7NR49; sara:101539056; tmu:101344695; umr:103679662; zca:113931110" "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "1752.7" "1559.0" "1814.7" "4248.0" "2235.9" "1502.7" "3232.9" "1611.4" "1681.2" "4677.0" "2784.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "20" "11" "22" "11" "597" "68.0" "6.35" "3859.94" "43.40" "9" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism; Mitochondrial tRNA aminoacylation" "" "3" "0" "466.1" "444.8" "613.0" "1598.3" "756.4" "467.9" "901.7" "488.3" "615.2" "2852.4" "3860.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "44" "14" "28" "12" "225" "24.7" "4.67" "4382.64" "43.37" "12" "12" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Eukaryotic Translation Elongation" "Translation factors" "2" "0" "1595.8" "1400.1" "1850.8" "4463.2" "2309.1" "1427.5" "2948.0" "1586.8" "1937.6" "4881.7" "3467.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "14" "13" "25" "11" "1008" "114.7" "7.68" "4163.45" "43.33" "12" "12" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "VEGFA-VEGFR2 signaling" "2" "2" "521.4" "455.0" "599.5" "1306.0" "772.2" "527.1" "1052.4" "489.4" "706.6" "2584.2" "2606.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "30" "13" "29" "13" "504" "56.0" "8.53" "5003.16" "43.20" "13" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "RHOG GTPase cycle; Metabolism of folate and pterines" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling" "10" "0" "892.2" "865.9" "1157.9" "3607.1" "1641.0" "859.1" "1483.5" "1000.7" "981.3" "2442.4" "2196.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "18" "8" "16" "8" "792" "90.0" "7.15" "2428.65" "43.14" "5" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Interconversion of nucleotide di- and triphosphates" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "199.7" "176.0" "256.6" "612.2" "339.6" "205.8" "430.8" "258.0" "361.3" "1307.8" "1636.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "25" "10" "23" "5" "429" "49.4" "6.81" "4121.45" "43.13" "9" "10" "cell cycle OR cell proliferation" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "" "22q11.2 copy number variation syndrome" "1" "5" "491.9" "449.0" "594.3" "2594.8" "813.9" "401.2" "915.7" "529.8" "735.4" "4378.5" "4761.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "17" "19" "31" "18" "1410" "152.4" "8.60" "7921.42" "42.99" "18" "11" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Signaling by ALK fusions and activated point mutants" "Ectoderm differentiation" "2" "1" "1703.4" "1364.2" "1728.8" "3622.0" "2113.8" "1509.9" "2627.4" "1312.4" "1820.7" "4351.6" "3210.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "26" "10" "22" "10" "418" "47.3" "5.88" "3922.40" "42.94" "8" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "EPHB-mediated forward signaling; FCGR3A-mediated phagocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis" "Physico-chemical features and toxicity-associated pathways" "6" "0" "396.3" "370.5" "528.5" "1528.6" "718.9" "455.3" "839.9" "418.9" "801.3" "5281.7" "7763.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "23" "13" "28" "13" "522" "56.0" "8.78" "5926.29" "42.67" "13" "10" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1703.0" "1445.5" "1839.8" "4368.5" "2448.9" "1598.0" "2908.1" "1641.6" "1939.5" "5337.9" "5297.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "41" "8" "18" "8" "263" "29.5" "6.61" "3156.11" "42.57" "6" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "UCH proteinases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1081.4" "1045.6" "1230.8" "3055.7" "1655.8" "1101.4" "1650.3" "1017.9" "1156.5" "2672.8" "2215.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "55" "10" "33" "10" "136" "14.6" "10.04" "6249.20" "42.08" "8" "8" "transport" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "" "2" "0" "776.1" "611.7" "776.8" "2079.3" "1061.2" "667.7" "1211.3" "735.9" "3231.2" "26751.4" "14531.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "24" "14" "26" "7" "623" "69.6" "8.59" "4292.86" "42.03" "12" "12" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "7" "1012.7" "895.6" "1312.2" "4087.9" "1930.3" "995.2" "2256.6" "1042.5" "1168.9" "3375.2" "2240.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46778" "60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2" "58" "12" "26" "12" "160" "18.6" "10.49" "5458.41" "41.73" "10" "8" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf01157" "6144" "ENSG00000122026" "RPL21" "hsa:6144; P46778; Q16699" "SRP-dependent cotranslational protein targeting to membrane; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "2212.5" "1835.2" "2276.0" "4483.6" "2569.5" "1813.0" "3721.0" "1611.8" "2067.0" "5282.6" "2965.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46779" "60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "44" "12" "26" "12" "137" "15.7" "12.02" "5167.00" "41.61" "11" "10" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "2089.4" "1597.6" "2284.3" "4916.7" "2783.4" "1882.0" "4078.0" "1377.1" "1909.4" "4416.6" "2185.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "22" "9" "19" "9" "652" "70.7" "7.90" "3355.06" "41.45" "7" "8" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle" "" "4" "0" "145.2" "117.0" "189.0" "439.6" "252.1" "169.2" "291.2" "231.0" "713.5" "4249.5" "4038.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35268" "60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "67" "8" "18" "8" "128" "14.8" "9.19" "2926.91" "41.43" "6" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "SRP-dependent cotranslational protein targeting to membrane; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "658.9" "455.4" "684.8" "1743.5" "875.5" "573.3" "1193.8" "611.4" "811.9" "2845.1" "1743.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08779" "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" "16" "11" "30" "2" "473" "51.2" "5.05" "6008.25" "41.38" "11" "10" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00038" "3868" "ENSG00000186832" "KRT16" "A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8" "Formation of the cornified envelope" "Vitamin D receptor pathway" "3" "0" "1285.9" "354.4" "359.6" "138.2" "84.5" "100.3" "153.6" "45.7" "66.2" "190.3" "121.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "23" "9" "20" "9" "427" "45.2" "8.85" "3246.90" "41.26" "7" "9" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "6" "0" "450.3" "424.9" "573.3" "1576.9" "743.7" "454.2" "712.9" "425.6" "568.1" "2064.8" "3386.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "37" "8" "22" "5" "246" "28.2" "4.84" "3432.47" "41.21" "7" "7" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "249.4" "259.8" "347.0" "1129.4" "436.0" "230.0" "527.2" "368.3" "451.3" "1645.7" "1408.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1" "22" "9" "24" "9" "531" "57.2" "9.17" "4795.24" "41.08" "7" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "749887" "ENSPPYG00000009289; ENSPTRG00000010165" "PTBP1" "A0A2J8IKP3; A0A2J8RA51; A0A6D2WFY9; A0A8I5YPF9; K7AXA8" "" "" "0" "0" "841.1" "777.8" "903.4" "2272.0" "1170.7" "770.1" "1732.7" "870.0" "895.5" "3462.3" "4057.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02543" "60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2" "52" "10" "25" "10" "176" "20.7" "10.71" "4231.73" "40.98" "10" "9" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01775" "6142" "ENSG00000105640" "RPL18A" "hsa:6142; Q02543" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "2639.6" "2086.0" "2555.4" "5030.7" "3001.3" "2222.5" "4481.2" "1875.6" "2086.6" "4775.1" "2398.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "7" "12" "22" "12" "2035" "208.6" "7.46" "3740.58" "40.85" "10" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "Mitochondrial gene expression; Pleural mesothelioma" "6" "0" "1191.1" "1076.8" "1234.3" "2323.6" "1387.8" "1065.2" "1758.3" "917.0" "1174.2" "2885.1" "2452.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "31" "8" "24" "7" "198" "21.9" "5.97" "5196.68" "40.68" "8" "8" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; VEGFA-VEGFR2 signaling" "5" "0" "693.8" "611.0" "914.8" "5746.7" "1386.1" "356.1" "856.0" "628.1" "674.2" "1958.5" "2162.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "11" "10" "19" "10" "1107" "123.6" "7.03" "3660.61" "40.48" "8" "9" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "165.3" "153.0" "236.7" "579.6" "296.5" "188.8" "347.6" "212.4" "350.3" "1436.4" "1657.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "15" "12" "22" "12" "972" "112.2" "6.64" "4357.06" "40.39" "11" "11" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "194.8" "178.9" "290.6" "829.1" "429.0" "243.2" "426.5" "232.3" "335.6" "2949.8" "5269.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "5" "12" "22" "8" "2541" "269.6" "6.07" "3866.43" "40.34" "11" "9" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511" "7094" "ENSG00000137076" "TLN1" "A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "18" "4" "520.5" "467.8" "597.7" "1819.8" "863.9" "441.7" "887.3" "559.3" "1140.7" "5395.0" "6069.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46782" "40S ribosomal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "44" "11" "25" "11" "204" "22.9" "9.72" "4723.91" "40.31" "11" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1021.3" "949.9" "1220.5" "2453.2" "1548.0" "1145.8" "2145.1" "1123.8" "1041.2" "2637.2" "1870.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49207" "60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "41" "9" "26" "9" "117" "13.3" "11.47" "4628.84" "40.29" "9" "9" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "2530.9" "2371.4" "2749.9" "5226.6" "3100.7" "2314.1" "4794.3" "2134.8" "2490.7" "5410.6" "2897.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P40429" "60S ribosomal protein L13a OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2" "37" "11" "29" "11" "203" "23.6" "10.93" "5766.22" "40.17" "11" "8" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00572" "23521" "ENSG00000142541" "RPL13A" "A8K505; hsa:23521; P40429" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "1884.7" "1584.0" "2023.5" "4839.3" "2414.6" "1629.1" "3905.1" "1654.8" "1920.2" "5471.7" "3120.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "25" "7" "14" "6" "397" "44.8" "7.08" "1318.90" "40.11" "4" "7" "stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "3" "1" "273.1" "224.0" "373.8" "1762.3" "535.4" "276.3" "549.0" "272.7" "336.0" "2352.4" "2306.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46781" "40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "57" "14" "27" "14" "194" "22.6" "10.65" "4393.91" "40.03" "12" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "1670.2" "1451.9" "1935.9" "5254.2" "2647.2" "1481.0" "3591.4" "1640.2" "2069.8" "6243.9" "4433.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "11" "12" "23" "12" "1140" "126.9" "5.26" "4213.16" "39.97" "12" "11" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "14" "0" "498.0" "471.3" "646.5" "2086.6" "868.8" "444.7" "1177.1" "569.6" "681.3" "3195.5" "2919.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "12" "9" "22" "8" "972" "109.4" "5.00" "4317.22" "39.77" "9" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; Ciliary landscape" "4" "0" "457.1" "403.1" "512.8" "1344.0" "680.6" "415.3" "757.0" "408.9" "475.3" "1918.8" "1787.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "10" "14" "27" "10" "1575" "180.5" "5.64" "5374.58" "39.65" "14" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "CDC42 GTPase cycle; RAC1 GTPase cycle; Neutrophil degranulation; RHO GTPases activate IQGAPs; RHOG GTPase cycle" "Ciliary landscape; G13 signaling pathway" "7" "0" "226.5" "208.4" "283.4" "744.5" "399.3" "256.0" "451.4" "299.0" "628.9" "4058.2" "3778.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "37" "9" "26" "4" "247" "28.3" "4.89" "4969.19" "39.49" "9" "9" "transport;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "21" "0" "134.7" "141.1" "189.9" "496.5" "246.2" "128.6" "328.2" "173.5" "237.8" "476.6" "332.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "22" "12" "24" "7" "614" "69.1" "8.92" "4557.26" "39.46" "11" "11" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "mRNA Splicing - Major Pathway; SUMOylation of transcription cofactors; Estrogen-dependent gene expression; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "Ciliary landscape" "6" "0" "1167.0" "1054.0" "1217.4" "2823.0" "1525.5" "996.9" "1935.9" "1001.0" "1161.8" "2746.0" "1813.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "29" "15" "28" "15" "437" "50.1" "6.67" "6209.16" "39.18" "15" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "Translation factors" "3" "0" "1559.4" "1375.6" "2011.7" "5934.3" "2795.3" "1532.4" "3186.4" "1603.0" "2038.5" "5610.6" "4105.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "32" "7" "22" "4" "245" "27.7" "4.78" "4155.07" "38.88" "7" "7" "transport;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "20" "0" "149.9" "145.5" "291.7" "2045.3" "504.6" "141.1" "430.2" "284.9" "289.5" "1945.3" "1627.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "18" "13" "23" "12" "840" "94.3" "5.19" "4447.02" "38.81" "11" "11" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway" "2" "1" "723.3" "718.5" "1025.1" "3994.3" "1570.6" "604.3" "1072.4" "752.4" "768.7" "1835.2" "1528.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "11" "11" "21" "11" "1135" "128.1" "7.83" "3710.71" "38.76" "10" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "175.9" "133.7" "223.5" "496.6" "250.2" "220.0" "326.2" "277.7" "694.7" "3608.6" "2512.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62851" "40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "46" "7" "26" "7" "125" "13.7" "10.11" "4539.35" "38.74" "7" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1388.1" "1252.1" "1405.2" "3012.7" "1653.6" "1215.7" "2422.3" "1323.0" "1396.2" "3543.9" "2800.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P0DME0" "Protein SETSIP OS=Homo sapiens OX=9606 GN=SETSIP PE=1 SV=1" "15" "5" "19" "5" "302" "34.9" "4.31" "4240.61" "38.71" "5" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "646817" "ENSG00000230667" "SETSIP" "hsa:646817; P0DME0" "" "" "0" "0" "681.0" "607.3" "827.7" "2563.0" "1012.0" "492.6" "1341.3" "688.6" "628.2" "2136.7" "1244.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NV70" "Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4" "16" "11" "18" "11" "894" "101.9" "6.61" "2691.53" "38.70" "7" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf09763, Pf15277" "55763" "ENSG00000090989" "EXOC1" "hsa:55763; Q504V4; Q8WUE7; Q96T15; Q9NV70; Q9NZE4" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "223.2" "205.6" "274.1" "759.7" "382.1" "266.4" "556.0" "597.6" "1252.7" "5143.8" "4121.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "23" "8" "15" "8" "476" "52.2" "6.15" "2802.37" "38.66" "5" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "mRNA Splicing - Major Pathway" "" "1" "0" "364.9" "321.8" "445.1" "996.3" "571.3" "358.6" "643.1" "365.9" "704.6" "2217.4" "2283.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNX3" "60S ribosomal protein L26-like 1 OS=Homo sapiens OX=9606 GN=RPL26L1 PE=1 SV=1" "44" "9" "31" "1" "145" "17.2" "10.55" "6020.49" "38.64" "9" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "51121" "ENSG00000037241" "RPL26L1" "B3KY82; D3DQM0; hsa:51121; Q9UNX3" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "545.3" "406.6" "462.8" "765.7" "498.2" "409.6" "787.2" "275.3" "370.8" "746.0" "340.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "26" "10" "19" "9" "528" "60.5" "7.52" "3184.20" "38.60" "9" "9" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "1" "279.6" "257.1" "315.6" "719.2" "393.8" "280.5" "579.7" "270.5" "505.6" "3029.0" "2983.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5X1" "Sorting nexin-9 OS=Homo sapiens OX=9606 GN=SNX9 PE=1 SV=1" "20" "10" "21" "10" "595" "66.6" "5.58" "3966.56" "38.60" "10" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00018, Pf00787, Pf10456" "51429" "ENSG00000130340" "SNX9" "hsa:51429; Q9BSI7; Q9BVM1; Q9UJH6; Q9UP20; Q9Y5X1" "Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "" "2" "0" "195.8" "165.3" "243.0" "593.6" "420.8" "488.9" "1215.2" "1062.0" "1924.3" "5436.3" "3268.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "29" "8" "22" "8" "275" "30.3" "7.50" "3884.50" "38.58" "8" "7" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "hsa:11212; O94903; Q6FI94" "" "" "0" "0" "244.0" "215.3" "299.1" "774.3" "394.5" "242.0" "431.0" "336.5" "890.4" "4558.6" "6215.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "25" "7" "19" "7" "423" "47.8" "6.65" "3911.50" "38.46" "7" "7" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis" "Ciliary landscape" "5" "0" "142.1" "128.3" "140.1" "383.4" "225.6" "166.8" "430.5" "264.5" "350.5" "1653.5" "2091.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42766" "60S ribosomal protein L35 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "53" "10" "26" "9" "123" "14.5" "11.05" "4794.98" "38.43" "9" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "1" "1528.7" "1258.1" "1575.7" "3273.1" "1894.3" "1396.1" "2872.3" "1071.0" "1470.1" "3281.8" "2172.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H078" "Caseinolytic peptidase B protein homolog OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "17" "9" "17" "9" "707" "78.7" "9.01" "3116.34" "38.30" "8" "9" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796, Pf13857" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "374.2" "308.2" "404.2" "908.2" "531.2" "353.6" "702.1" "386.4" "638.7" "3344.8" "4135.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "28" "7" "16" "7" "327" "36.1" "5.73" "2774.08" "38.16" "5" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "6" "0" "203.0" "193.6" "232.6" "734.1" "340.9" "266.2" "768.3" "384.2" "448.5" "3975.4" "6283.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "21" "11" "24" "11" "541" "59.6" "5.66" "5664.30" "38.11" "11" "10" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "769.4" "824.4" "1132.0" "5145.2" "1921.5" "781.1" "1927.3" "954.7" "1002.4" "3475.1" "2813.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62750" "60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "51" "10" "29" "10" "156" "17.7" "10.45" "6427.86" "37.84" "10" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1683.5" "1619.7" "1863.3" "3994.1" "2251.8" "1543.3" "3141.2" "1587.3" "1828.5" "4420.6" "2730.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "41" "10" "18" "9" "271" "31.5" "6.87" "2807.41" "37.80" "8" "10" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "PI and PC transport between ER and Golgi membranes" "" "1" "1" "789.8" "605.8" "1127.6" "2200.7" "1416.8" "740.1" "1857.6" "760.2" "1286.2" "2410.5" "1495.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "27" "10" "20" "9" "437" "50.6" "8.63" "4149.26" "37.66" "9" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "MAPK6/MAPK4 signaling" "" "1" "0" "583.9" "540.3" "713.5" "2461.6" "1125.6" "650.7" "1157.6" "678.8" "1039.6" "2962.6" "2790.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A0FGR8" "Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1" "9" "8" "21" "7" "921" "102.3" "9.26" "3644.15" "37.55" "6" "7" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00168, Pf17047" "57488" "ENSG00000117868" "ESYT2" "A0FGR8; A4D229; hsa:57488; Q69YJ2; Q6UKI4; Q6ZTU0; Q6ZVU1; Q9BQS0; Q9NW47; Q9ULJ2" "Glycosphingolipid metabolism" "" "1" "0" "239.8" "205.3" "301.3" "864.4" "464.7" "408.5" "875.8" "825.6" "1425.1" "3142.3" "2483.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "41" "11" "22" "11" "255" "28.4" "5.33" "3926.75" "37.51" "11" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1182.7" "1078.9" "1408.3" "3425.0" "1829.4" "1203.0" "1890.2" "936.0" "1192.0" "2464.8" "2044.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "11" "12" "25" "12" "1262" "144.4" "6.15" "5695.48" "37.50" "12" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Amino acid metabolism" "3" "0" "644.4" "622.8" "840.2" "3085.1" "1261.1" "562.3" "1061.4" "709.4" "801.9" "3263.6" "4640.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "60" "7" "18" "7" "111" "13.5" "8.78" "3756.89" "37.47" "7" "7" "other metabolic processes;transport" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; 11p11.2 copy number variation syndrome" "5" "0" "695.4" "608.0" "999.9" "2518.1" "1223.4" "724.0" "1456.6" "729.0" "1137.7" "2411.4" "1771.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "18" "11" "22" "11" "645" "73.5" "8.02" "4595.65" "37.39" "11" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "Mitochondrial tRNA aminoacylation" "" "1" "0" "826.7" "748.7" "969.1" "2073.3" "1174.1" "971.0" "2301.3" "845.9" "1098.2" "3869.2" "3102.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "13" "9" "16" "9" "958" "108.9" "7.14" "1857.41" "37.18" "4" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "506.4" "445.6" "651.4" "1651.6" "862.7" "577.9" "1145.4" "577.3" "710.7" "2425.5" "3148.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "7" "8" "24" "2" "1278" "148.3" "7.31" "4397.17" "37.15" "8" "6" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "Fragile X syndrome; Regulation of actin cytoskeleton" "7" "0" "26.1" "31.4" "41.7" "106.7" "55.5" "38.9" "55.0" "31.8" "42.2" "110.6" "90.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "27" "7" "18" "4" "365" "38.6" "6.79" "3714.97" "37.10" "6" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "7" "4" "419.4" "391.7" "631.7" "3330.3" "964.9" "278.2" "841.0" "604.9" "682.1" "2232.5" "2218.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "36" "7" "15" "7" "301" "33.2" "8.82" "2671.06" "37.08" "4" "7" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "hsa:51070; Q96FD2; Q9Y314" "NOSIP mediated eNOS trafficking" "" "1" "0" "270.5" "230.9" "322.9" "980.2" "451.4" "277.1" "504.1" "299.7" "776.0" "3492.9" "3596.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "18" "11" "20" "11" "814" "92.4" "5.00" "3544.22" "36.95" "10" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "614.2" "533.3" "751.0" "2449.1" "1034.7" "611.0" "1199.9" "574.7" "730.6" "2486.1" "1694.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "8" "14" "25" "13" "1868" "208.3" "6.90" "4518.95" "36.82" "13" "11" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "" "2" "1" "279.8" "278.1" "379.6" "897.9" "483.9" "319.7" "645.8" "685.3" "2051.7" "8156.5" "5480.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "17" "8" "24" "8" "466" "51.7" "8.32" "4464.82" "36.76" "7" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "6" "0" "1792.5" "1610.5" "1968.9" "3162.6" "2064.2" "1771.7" "3685.0" "1479.7" "1685.7" "4345.6" "2598.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "24" "8" "25" "7" "372" "38.7" "9.13" "5222.82" "36.66" "7" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "mRNA processing" "6" "0" "1186.5" "1058.9" "1240.9" "2623.5" "1460.2" "1093.1" "1743.7" "946.9" "1035.0" "2608.0" "1899.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q05682" "Caldesmon OS=Homo sapiens OX=9606 GN=CALD1 PE=1 SV=3" "12" "8" "19" "8" "793" "93.2" "5.66" "3591.45" "36.46" "7" "7" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf02029" "800" "ENSG00000122786" "CALD1" "A8K0X1; hsa:800; Q05682; Q13978; Q13979; Q14741; Q14742; Q9UD91" "Smooth Muscle Contraction" "Myometrial relaxation and contraction pathways" "2" "0" "1119.9" "846.8" "1071.4" "1881.6" "1266.7" "966.6" "1307.4" "765.4" "1199.4" "1657.9" "1192.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "56" "9" "15" "9" "241" "26.4" "4.79" "3628.70" "36.32" "8" "7" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "UCH proteinases; Separation of Sister Chromatids; Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "677.7" "627.7" "821.1" "2541.1" "1113.3" "600.9" "1035.3" "589.7" "723.9" "2002.0" "1658.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46783" "40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "47" "10" "31" "10" "165" "18.9" "10.15" "5925.58" "36.32" "9" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "3134.8" "2430.2" "2878.8" "5599.4" "3380.0" "2777.4" "4983.4" "2239.5" "2745.6" "6772.9" "4507.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "41" "10" "19" "10" "223" "25.8" "9.54" "3009.75" "35.76" "9" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "" "VEGFA-VEGFR2 signaling" "1" "0" "1281.5" "1049.8" "1356.8" "2712.3" "1646.8" "1107.2" "2136.4" "966.2" "1296.7" "3354.2" "2815.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "31" "15" "21" "15" "545" "60.5" "6.49" "4082.35" "35.68" "12" "9" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "915.0" "915.9" "1220.5" "5237.5" "1788.8" "818.6" "1934.9" "1065.7" "1015.2" "4161.7" "3482.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZI8" "Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2" "19" "8" "16" "6" "577" "63.4" "9.20" "3108.85" "35.62" "7" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10642" "ENSG00000159217" "IGF2BP1" "C9JT33; hsa:10642; Q9NZI8" "MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "Brain-derived neurotrophic factor (BDNF) signaling pathway; eIF5A regulation in response to inhibition of the nuclear export system" "4" "2" "486.7" "449.1" "658.8" "2141.2" "911.6" "498.4" "1130.1" "484.0" "562.5" "2051.8" "1533.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42167" "Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "26" "10" "17" "5" "454" "50.6" "9.38" "3023.04" "35.53" "7" "9" "" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198" "7112" "ENSG00000120802" "TMPO" "A2T926; hsa:7112; P42167; Q14861" "RHOG GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "12" "5" "1173.5" "1023.6" "1448.3" "3765.2" "1930.9" "1154.4" "1858.9" "1069.7" "1199.2" "2631.0" "2303.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "43" "10" "21" "10" "176" "20.7" "6.34" "5480.05" "35.48" "10" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "" "2" "0" "170.4" "164.2" "238.7" "658.9" "352.3" "310.7" "712.7" "768.0" "1430.9" "4240.7" "4580.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "22" "6" "16" "5" "348" "37.9" "7.23" "2226.66" "35.40" "4" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "Purine salvage" "" "1" "1" "231.8" "204.8" "278.4" "685.4" "373.9" "260.3" "462.6" "386.9" "1028.1" "6854.7" "6436.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96JJ3" "Engulfment and cell motility protein 2 OS=Homo sapiens OX=9606 GN=ELMO2 PE=1 SV=2" "14" "9" "19" "9" "720" "82.6" "5.90" "4152.92" "35.30" "9" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf04727, Pf11841, Pf16457" "63916" "ENSG00000062598" "ELMO2" "E1P5T3; hsa:63916; Q5JVZ6; Q7Z5G9; Q96CJ2; Q96JJ3; Q96ME5; Q96PA9; Q9H938; Q9H9L5; Q9HAH0; Q9NQQ6" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; RHOG GTPase cycle; VEGFA-VEGFR2 Pathway" "" "5" "0" "219.0" "197.7" "294.8" "744.4" "456.8" "419.8" "908.4" "654.4" "1341.2" "4435.7" "3330.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "19" "8" "20" "8" "496" "56.8" "7.80" "3804.21" "35.29" "8" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "" "3" "0" "439.8" "332.0" "489.8" "975.2" "591.9" "397.5" "696.5" "343.5" "549.3" "2842.7" "4293.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVI7" "ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A PE=1 SV=2" "14" "8" "15" "8" "634" "71.3" "8.98" "2292.67" "35.27" "5" "8" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00004, Pf12037" "55210" "ENSG00000197785" "ATAD3A" "B3KPB3; D2K8Q1; G3V1I6; hsa:55210; Q5SV23; Q8N275; Q96A50; Q9NVI7" "" "1p36 copy number variation syndrome" "1" "0" "603.6" "594.9" "712.9" "1719.7" "907.3" "562.6" "1187.0" "645.0" "733.2" "1838.7" "1286.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "42" "11" "21" "11" "250" "28.7" "8.75" "5036.86" "35.22" "11" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; hsa:51119; Q96FX0; Q9NV53; Q9Y3A5" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "770.4" "664.0" "853.3" "1737.3" "1015.8" "682.5" "1303.7" "872.8" "2200.5" "8382.6" "8330.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "19" "8" "20" "6" "433" "45.5" "8.69" "3950.88" "35.21" "8" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "tRNA processing in the nucleus" "" "1" "2" "1198.9" "961.4" "1204.3" "2194.1" "1590.4" "1121.0" "1804.4" "788.8" "1106.2" "2721.9" "1748.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "32" "10" "22" "10" "328" "37.1" "6.84" "4970.33" "35.15" "10" "9" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "12" "0" "624.4" "546.3" "715.4" "1751.3" "885.3" "609.3" "1184.3" "657.5" "836.6" "4615.2" "6271.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "47" "6" "18" "2" "152" "17.3" "8.41" "3997.62" "35.10" "6" "6" "cell adhesion;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Neutrophil degranulation; Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "Pyrimidine metabolism" "5" "0" "199.2" "195.6" "404.8" "4161.3" "960.6" "96.7" "288.6" "330.8" "314.4" "1015.1" "1028.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61254" "60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "44" "9" "29" "1" "145" "17.2" "10.55" "5660.73" "35.01" "9" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "11" "2815.0" "2500.3" "2759.0" "4988.9" "3016.7" "2441.2" "4792.0" "2120.7" "2370.2" "5063.6" "2603.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UHR4" "Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Homo sapiens OX=9606 GN=BAIAP2L1 PE=1 SV=2" "22" "8" "14" "8" "511" "56.8" "8.68" "2340.10" "34.95" "6" "8" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf08397, Pf14604" "55971" "ENSG00000006453" "BAIAP2L1" "A4D268; hsa:55971; Q75L21; Q75L22; Q96CV4; Q9H5F5; Q9UHR4; Q9Y2M8" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle" "" "4" "0" "292.7" "186.7" "266.3" "617.7" "334.1" "260.7" "473.4" "271.7" "666.8" "2215.6" "1667.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "29" "9" "21" "8" "378" "39.6" "9.01" "3879.89" "34.91" "6" "8" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "transporter activity;nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "0" "739.7" "689.0" "816.0" "2036.3" "1026.3" "733.1" "1312.0" "615.8" "710.5" "1965.6" "1091.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46776" "60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "34" "7" "21" "7" "148" "16.6" "11.00" "4190.71" "34.76" "7" "6" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1094.8" "967.0" "1157.5" "2733.9" "1501.0" "1028.7" "2278.6" "962.8" "1038.9" "2843.2" "1619.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05141" "ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7" "42" "13" "26" "5" "298" "32.8" "9.69" "4793.44" "34.70" "12" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "transporter activity;other molecular function" "Pf00153" "292" "ENSG00000005022" "SLC25A5" "B2RCV1; hsa:292; O43350; P05141" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease" "5" "8" "846.8" "876.0" "1096.3" "4123.2" "1629.8" "916.5" "1749.1" "1066.3" "1074.9" "5302.2" "5319.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "10" "10" "21" "10" "1230" "136.3" "5.78" "4187.94" "34.62" "10" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "Endoderm differentiation" "4" "0" "148.8" "144.2" "237.6" "1072.2" "387.4" "156.9" "343.4" "276.0" "395.2" "1731.6" "2362.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "27" "8" "21" "8" "306" "33.7" "5.08" "5164.87" "34.60" "8" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "6" "0" "831.3" "769.0" "1055.1" "3032.5" "1497.0" "775.7" "1488.5" "638.5" "821.5" "1972.8" "1147.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "29" "9" "21" "9" "254" "29.5" "5.95" "3657.88" "34.55" "9" "8" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "183.9" "148.7" "245.2" "806.6" "331.4" "206.4" "346.0" "206.1" "281.5" "5299.4" "3805.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "16" "11" "20" "11" "788" "85.2" "4.30" "3315.58" "34.52" "9" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "1041.4" "846.6" "1297.2" "4711.0" "1766.8" "772.0" "1540.9" "820.4" "1032.9" "2539.0" "1695.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "55" "7" "19" "7" "140" "15.0" "8.27" "4027.74" "34.48" "7" "7" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "9" "0" "380.9" "408.7" "835.2" "7628.8" "1778.9" "247.4" "721.3" "692.6" "612.6" "1708.9" "1828.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "14" "8" "16" "8" "651" "70.8" "8.51" "2147.78" "34.42" "5" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "10" "0" "232.2" "194.7" "246.1" "576.3" "326.4" "256.5" "461.0" "411.5" "910.8" "3968.9" "3245.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "32" "8" "17" "2" "180" "20.3" "6.35" "2887.95" "34.33" "7" "7" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "57.8" "47.5" "70.5" "187.9" "177.2" "266.6" "701.1" "544.7" "882.1" "1316.8" "998.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "5" "10" "17" "8" "2602" "278.0" "5.73" "3490.22" "34.25" "8" "9" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "ISG15 antiviral mechanism" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host" "5" "1" "398.6" "409.3" "550.3" "2331.5" "863.6" "322.5" "560.1" "437.4" "461.8" "1092.6" "941.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "12" "9" "17" "9" "1087" "114.5" "7.11" "3156.14" "34.24" "8" "9" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "" "VEGFA-VEGFR2 signaling" "1" "0" "638.6" "557.4" "853.4" "1940.1" "1066.5" "598.7" "1154.7" "635.7" "816.0" "1563.0" "1100.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "23" "12" "25" "12" "563" "61.3" "7.68" "5863.41" "34.04" "12" "9" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency" "" "3" "0" "1302.5" "1210.1" "1786.0" "2472.9" "1803.9" "1386.8" "2201.8" "1263.6" "1587.9" "2642.5" "1821.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "9" "8" "15" "8" "1042" "117.7" "6.52" "2028.55" "33.83" "6" "8" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway" "" "2" "0" "196.8" "180.1" "246.7" "736.5" "336.2" "227.6" "417.7" "202.4" "302.0" "1575.5" "1845.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "19" "8" "18" "8" "509" "54.1" "7.85" "3199.48" "33.79" "6" "8" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Glycine degradation" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "17" "0" "1406.9" "1209.6" "1565.8" "3145.9" "1878.3" "1142.9" "2319.2" "1113.2" "1417.8" "2897.4" "1824.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "28" "9" "13" "9" "432" "47.6" "5.97" "1205.72" "33.74" "4" "9" "other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis" "VEGFA-VEGFR2 signaling" "4" "0" "507.1" "495.1" "644.9" "1824.4" "814.5" "477.3" "1246.8" "559.2" "546.0" "2187.6" "1412.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "32" "6" "21" "6" "227" "24.6" "7.21" "5056.21" "33.60" "6" "5" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Protein repair" "Primary ovarian insufficiency" "2" "0" "780.7" "667.2" "905.1" "2715.4" "1148.4" "704.2" "1276.0" "617.0" "902.0" "2013.2" "1236.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35232" "Prohibitin OS=Homo sapiens OX=9606 GN=PHB PE=1 SV=1" "45" "11" "22" "11" "272" "29.8" "5.76" "5058.26" "33.46" "9" "9" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "5245" "ENSG00000167085" "PHB1" "B4DY47; hsa:5245; P35232; Q4VBQ0" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Processing of SMDT1" "" "5" "0" "666.3" "691.8" "1025.2" "4267.0" "1498.0" "628.0" "1303.3" "908.5" "953.9" "2696.1" "2765.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "17" "11" "23" "4" "633" "70.9" "8.13" "3878.79" "33.44" "10" "9" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "385.9" "340.5" "481.0" "1221.0" "668.9" "378.1" "731.7" "293.7" "395.4" "892.8" "571.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "38" "6" "15" "6" "234" "25.9" "7.43" "2656.17" "33.22" "5" "6" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "389.1" "381.5" "469.7" "1314.1" "655.1" "379.1" "633.7" "391.6" "460.1" "1100.5" "905.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P83881" "60S ribosomal protein L36a OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2" "58" "12" "19" "3" "106" "12.4" "10.58" "2815.34" "33.17" "8" "10" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus" "other molecular function" "Pf00935" "6173" "ENSG00000241343" "RPL36A" "hsa:6173; P09896; P10661; P83881; Q08ES5; Q5J9I6" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "9" "2654.2" "2008.6" "2387.4" "4371.6" "2714.0" "2097.2" "4028.4" "1647.8" "2063.4" "4507.7" "2382.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "4" "9" "18" "9" "2511" "273.3" "6.44" "2511.29" "33.14" "7" "9" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf14765, Pf16197" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "18" "0" "482.5" "499.6" "645.8" "2482.1" "1023.8" "432.9" "733.6" "629.3" "592.1" "1354.2" "1203.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14554" "Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1" "13" "6" "18" "6" "519" "59.6" "7.91" "3203.97" "33.11" "6" "6" "other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00085" "10954" "ENSG00000065485" "PDIA5" "D3DN95; hsa:10954; Q14554; Q9BV43" "XBP1(S) activates chaperone genes" "" "1" "0" "95.0" "95.0" "130.5" "296.6" "168.5" "103.4" "222.8" "170.1" "901.2" "4343.3" "3625.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "24" "14" "26" "14" "543" "62.6" "6.80" "4860.08" "33.06" "13" "10" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "VEGFA-VEGFR2 signaling" "3" "0" "1396.9" "1263.8" "2016.9" "9452.8" "3160.4" "1203.4" "2221.0" "1463.7" "1790.6" "4041.5" "3344.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "17" "8" "14" "7" "523" "58.7" "6.67" "2525.60" "33.04" "7" "6" "stress response;other biological processes" "nucleus;other cell component" "" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "862.1" "776.0" "910.5" "1773.9" "1073.6" "820.9" "1512.5" "627.9" "930.5" "2182.4" "1546.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q4VCS5" "Angiomotin OS=Homo sapiens OX=9606 GN=AMOT PE=1 SV=1" "11" "9" "17" "9" "1084" "118.0" "7.64" "2989.49" "33.02" "7" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12240" "154796" "ENSG00000126016" "AMOT" "hsa:154796; Q4VCS5; Q504X5; Q9HD27; Q9UPT1" "" "VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "3" "0" "554.6" "509.1" "591.3" "1484.8" "769.0" "464.7" "922.6" "521.4" "628.8" "1735.8" "1358.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "28" "8" "16" "5" "251" "28.8" "4.06" "2842.41" "32.95" "7" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "3" "773.2" "704.3" "1227.0" "3604.4" "1561.3" "699.0" "2047.5" "870.8" "967.0" "3081.6" "1788.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "16" "8" "21" "8" "582" "63.8" "9.32" "4589.37" "32.92" "8" "7" "RNA metabolism OR transcription;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "3" "0" "500.8" "448.0" "507.7" "1034.7" "593.4" "451.9" "793.3" "385.6" "662.9" "3142.8" "4017.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "23" "7" "18" "7" "391" "42.3" "10.05" "3681.98" "32.90" "7" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA Splicing - Major Pathway; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "8" "0" "911.7" "828.6" "1130.7" "3280.7" "1518.2" "774.2" "1692.7" "878.0" "991.4" "2349.3" "1488.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "15" "7" "21" "7" "531" "58.0" "6.68" "3932.61" "32.87" "7" "6" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "578.4" "551.7" "724.1" "2524.7" "1058.6" "551.0" "1045.8" "674.1" "622.0" "2206.9" "2149.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "31" "11" "23" "10" "340" "38.0" "8.63" "4712.30" "32.64" "11" "8" "RNA metabolism OR transcription;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "Nuclear receptors meta-pathway; NRF2 pathway" "7" "1" "1200.7" "1010.3" "1227.2" "2899.0" "1603.9" "1151.4" "2379.0" "987.6" "1314.7" "3623.9" "2491.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "23" "5" "18" "5" "111" "12.2" "3.78" "4159.84" "32.61" "5" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "" "VEGFA-VEGFR2 signaling" "1" "0" "299.4" "311.6" "385.4" "1340.9" "557.6" "244.1" "279.8" "283.6" "240.0" "303.1" "279.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99584" "Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1" "49" "6" "19" "6" "98" "11.5" "6.16" "3286.16" "32.51" "6" "5" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6284" "ENSG00000189171" "S100A13" "hsa:6284; Q52PI9; Q6FGF8; Q99584" "" "" "0" "0" "298.1" "270.2" "362.4" "857.1" "449.3" "306.0" "479.6" "405.5" "1605.6" "10275.2" "9878.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "19" "9" "19" "9" "491" "55.5" "6.74" "3053.42" "32.48" "8" "9" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "" "5" "0" "193.4" "170.2" "233.5" "533.4" "312.9" "223.6" "363.4" "224.0" "235.0" "1856.8" "3019.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62841" "40S ribosomal protein S15 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2" "39" "4" "15" "4" "145" "17.0" "10.39" "2735.12" "32.43" "2" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00203" "6209" "ENSG00000115268" "RPS15" "A5D8V9; hsa:6209; P11174; P62841; Q3KRA1; Q9UDC2" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "556.9" "479.0" "495.1" "1013.5" "529.8" "411.5" "813.1" "495.3" "451.9" "1270.8" "1095.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "16" "9" "16" "9" "647" "69.0" "7.84" "2295.83" "32.36" "7" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis" "7" "0" "577.4" "548.9" "730.1" "2080.9" "968.0" "583.3" "1601.5" "651.9" "743.5" "2692.1" "1438.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "53" "7" "17" "3" "152" "17.1" "6.19" "3417.37" "32.26" "6" "7" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "Pyrimidine metabolism" "4" "6" "338.5" "319.7" "622.2" "7375.7" "1646.9" "79.3" "437.5" "559.7" "427.5" "1681.6" "2192.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61353" "60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "65" "12" "25" "12" "136" "15.8" "10.56" "4467.89" "32.22" "9" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "GTP hydrolysis and joining of the 60S ribosomal subunit; L13a-mediated translational silencing of Ceruloplasmin expression; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "3322.9" "2894.6" "3332.9" "7496.1" "3812.9" "2569.9" "5947.5" "2568.4" "2830.6" "7657.2" "4037.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "9" "6" "14" "6" "1102" "128.2" "5.55" "3429.76" "32.19" "6" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Regulation of TP53 Degradation; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of PTEN localization" "Nucleotide excision repair in xeroderma pigmentosum" "9" "0" "159.1" "146.4" "177.5" "546.8" "268.7" "161.7" "298.9" "167.6" "206.1" "559.3" "430.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62979" "Ubiquitin-40S ribosomal protein S27a OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2" "60" "10" "18" "10" "156" "18.0" "9.64" "2552.17" "32.17" "7" "7" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01599" "6233" "ENSG00000143947" "RPS27A" "hsa:6233; P02248; P02249; P02250; P14798; P62979; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BQ77; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Oxidative Stress Induced Senescence; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Ub-specific processing proteases; Peroxisomal protein import; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "Cytoplasmic ribosomal proteins" "201" "0" "1972.4" "1824.0" "2336.3" "5852.2" "3159.0" "1739.1" "3463.0" "2101.2" "2199.4" "4278.1" "3058.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "18" "9" "15" "9" "689" "79.5" "7.28" "2206.73" "32.04" "7" "8" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis; Calmodulin induced events" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway" "8" "0" "209.9" "183.7" "260.4" "757.8" "366.7" "237.0" "415.4" "255.1" "527.4" "3103.6" "3721.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "40" "6" "14" "6" "158" "18.0" "8.66" "2612.64" "31.91" "5" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; hsa:7329; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "Androgen receptor signaling pathway" "24" "0" "194.5" "164.6" "254.9" "1403.5" "430.2" "179.7" "348.3" "250.6" "665.0" "7021.3" "9392.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00471" "Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1" "15" "8" "15" "8" "708" "81.8" "6.71" "2609.95" "31.85" "7" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf07393" "10640" "ENSG00000070367" "EXOC5" "B2R6C5; hsa:10640; O00471; Q8IW24" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "100.5" "90.1" "106.7" "296.3" "145.5" "93.6" "176.7" "159.4" "313.5" "1816.8" "1463.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "8" "10" "18" "10" "1217" "135.5" "5.26" "2652.39" "31.79" "8" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "858.7" "699.7" "966.1" "2975.2" "1347.0" "870.3" "1483.0" "755.2" "911.6" "3246.5" "2347.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "48" "4" "13" "4" "126" "13.9" "10.32" "2343.80" "31.73" "3" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "376.3" "363.2" "529.9" "1870.0" "765.1" "383.6" "922.6" "490.9" "517.7" "2007.3" "1440.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "20" "8" "16" "8" "445" "50.4" "8.27" "3343.84" "31.49" "7" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Lipid metabolism pathway" "3" "0" "352.8" "374.3" "479.8" "883.2" "546.9" "464.8" "780.8" "438.7" "505.1" "1323.9" "822.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "6" "8" "17" "8" "1599" "175.4" "5.33" "3431.02" "31.43" "7" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Deadenylation of mRNA; ISG15 antiviral mechanism; mTORC1-mediated signalling" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "18" "0" "913.1" "747.9" "987.5" "2635.4" "1415.6" "866.5" "1456.2" "708.0" "794.0" "1924.9" "1286.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "27" "8" "17" "8" "300" "34.3" "7.36" "2235.51" "31.43" "5" "8" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "207.3" "205.1" "277.1" "761.4" "374.8" "222.3" "382.6" "231.3" "376.0" "3017.7" "4498.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3U8" "60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3" "44" "10" "21" "10" "105" "12.2" "11.59" "4898.98" "31.40" "10" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf01158" "25873" "ENSG00000130255" "RPL36" "B2R4Y1; D6W634; hsa:25873; Q6FIG1; Q9UQF6; Q9Y3U8" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1530.3" "1420.2" "1618.2" "4566.1" "2104.3" "1388.4" "3216.7" "1492.0" "1630.9" "5613.4" "3655.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94826" "Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1" "18" "8" "15" "8" "608" "67.4" "7.12" "2954.22" "31.37" "7" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00515, Pf13181" "9868" "ENSG00000154174" "TOMM70" "D3DN48; hsa:9868; O94826" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "9" "0" "251.1" "247.5" "344.8" "1083.9" "471.0" "248.1" "492.8" "283.4" "345.7" "1932.3" "2608.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "70" "9" "22" "9" "102" "10.9" "8.92" "4138.51" "31.15" "7" "6" "stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "RHOG GTPase cycle" "" "1" "0" "773.5" "864.2" "1275.8" "5500.6" "2061.0" "714.9" "1309.4" "1445.3" "1932.2" "5179.3" "10355.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86X10" "Ral GTPase-activating protein subunit beta OS=Homo sapiens OX=9606 GN=RALGAPB PE=1 SV=1" "9" "8" "14" "8" "1494" "166.7" "6.79" "2758.43" "31.14" "7" "7" "other biological processes" "" "enzyme regulator activity;other molecular function" "Pf20412" "57148" "ENSG00000170471" "RALGAPB" "A2A2E8; A2A2E9; hsa:57148; Q5TG31; Q86X10; Q8N3D1; Q8WWC0; Q9H3X8; Q9UJR1; Q9ULK1; Q9Y3G9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "129.7" "99.6" "147.1" "301.8" "174.9" "149.8" "306.4" "326.8" "684.0" "2505.8" "2093.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12236" "ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4" "31" "10" "21" "1" "298" "32.8" "9.74" "3793.12" "31.07" "9" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf00153" "293" "ENSG00000169100" "SLC25A6" "hsa:293; P12236; Q96C49" "Mitochondrial protein import; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Influenza Virus Induced Apoptosis; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease" "7" "1" "190.4" "169.5" "238.4" "967.0" "330.5" "155.1" "338.3" "213.9" "249.5" "935.2" "909.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "9" "6" "14" "6" "808" "90.9" "5.77" "3560.29" "30.95" "6" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication; 10q11.21q11.23 copy number variation syndrome" "12" "0" "269.0" "268.3" "391.9" "1533.2" "607.2" "254.0" "702.9" "405.4" "479.4" "1460.4" "1314.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "11" "9" "16" "9" "998" "112.3" "6.39" "3106.12" "30.89" "6" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "3" "0" "391.6" "389.6" "574.1" "1848.7" "737.9" "398.0" "869.8" "516.2" "568.0" "1888.4" "1592.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62847" "40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "34" "6" "19" "6" "133" "15.4" "10.78" "4480.11" "30.88" "6" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "621.0" "478.3" "690.5" "1734.4" "911.2" "641.0" "1262.6" "530.4" "659.9" "1726.3" "1257.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "17" "8" "16" "8" "613" "66.9" "8.95" "2572.52" "30.72" "6" "8" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; hsa:9131; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "3" "0" "471.8" "457.2" "674.7" "1916.2" "819.1" "514.8" "929.3" "525.2" "595.8" "1732.2" "1283.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "16" "8" "17" "8" "649" "73.4" "7.88" "3115.66" "30.57" "7" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; hsa:5965; P46063" "" "Progeria-associated lipodystrophy" "1" "0" "431.7" "365.7" "475.2" "1012.1" "611.2" "448.9" "902.3" "449.2" "484.3" "1529.5" "1076.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "29" "8" "22" "8" "318" "35.9" "7.11" "3992.84" "30.44" "8" "8" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Neutrophil degranulation" "Fluoropyrimidine activity" "2" "0" "243.0" "222.3" "290.4" "680.6" "367.4" "238.3" "644.3" "1058.5" "2349.3" "6084.9" "5668.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "13" "9" "17" "9" "793" "88.8" "5.22" "3429.81" "30.37" "8" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "729.4" "587.6" "816.1" "1688.2" "1016.3" "725.0" "1202.0" "639.9" "748.4" "1559.8" "1005.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WXH0" "Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3" "2" "10" "16" "9" "6885" "795.9" "5.36" "2126.75" "30.35" "6" "10" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23224" "ENSG00000054654" "SYNE2" "B4DND7; B4DPR6; hsa:23224; I6XXQ5; Q540G1; Q86YP9; Q8N1S3; Q8NF49; Q8TER7; Q8WWW3; Q8WWW4; Q8WWW5; Q8WXH0; Q8WXH1; Q9NU50; Q9UFQ4; Q9Y2L4; Q9Y4R1" "Meiotic synapsis" "Ovarian infertility; Rett syndrome causing genes; Envelope proteins and their potential roles in EDMD physiopathology" "4" "0" "56.5" "60.8" "74.6" "206.8" "106.1" "57.6" "113.5" "83.1" "198.4" "1611.7" "1776.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "5" "9" "17" "9" "2364" "274.4" "5.57" "2755.23" "30.30" "8" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Signaling by FLT3 fusion proteins; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Interaction between L1 and Ankyrins" "Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "142.7" "139.9" "207.1" "810.9" "305.5" "166.9" "282.4" "180.6" "219.3" "1327.7" "2111.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "34" "8" "15" "8" "246" "27.4" "6.76" "3009.41" "30.27" "7" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "656.8" "679.3" "764.4" "2028.7" "1014.0" "589.7" "1071.8" "739.4" "737.6" "2045.3" "2032.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UQB8" "Brain-specific angiogenesis inhibitor 1-associated protein 2 OS=Homo sapiens OX=9606 GN=BAIAP2 PE=1 SV=1" "17" "5" "9" "5" "552" "60.8" "8.90" "1519.22" "30.13" "2" "5" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf07653, Pf08397" "10458" "ENSG00000175866" "BAIAP2" "hsa:10458; O43858; Q53HB1; Q86WC1; Q8N5C0; Q96CR7; Q9UBR3; Q9UQ43; Q9UQB8" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Regulation of actin cytoskeleton" "8" "0" "175.7" "135.2" "153.0" "291.7" "215.3" "168.1" "248.2" "148.2" "451.3" "1388.7" "987.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "8" "9" "18" "8" "1098" "123.8" "8.65" "2888.70" "30.06" "7" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "mRNA Splicing - Major Pathway" "" "1" "0" "669.1" "566.8" "661.2" "1403.8" "870.3" "701.1" "1245.5" "606.8" "762.3" "2484.9" "2246.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "10" "8" "12" "5" "1239" "142.0" "7.46" "1286.49" "30.02" "4" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "Oxidative Stress Induced Senescence" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "7" "3" "140.5" "122.3" "159.4" "393.1" "211.6" "138.3" "259.0" "160.2" "372.5" "2630.0" "1676.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "30" "8" "13" "7" "391" "45.3" "4.46" "2308.40" "29.84" "6" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "1" "555.3" "466.6" "733.0" "2320.6" "917.8" "591.5" "1060.6" "538.1" "592.2" "2237.3" "1658.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "32" "6" "15" "6" "205" "22.9" "6.55" "3044.22" "29.72" "5" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Separation of Sister Chromatids; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; The role of GTSE1 in G2/M progression after G2 checkpoint; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "415.3" "425.7" "520.5" "1249.7" "679.1" "418.4" "719.3" "430.2" "472.7" "1066.0" "897.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "24" "9" "16" "9" "422" "47.4" "6.48" "2423.37" "29.71" "7" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "63" "0" "380.5" "366.5" "477.1" "1674.4" "693.4" "377.7" "691.3" "437.9" "446.7" "2063.8" "2153.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "22" "5" "12" "5" "320" "35.6" "6.13" "2210.82" "29.58" "4" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "438.5" "416.3" "522.0" "1501.1" "692.2" "472.9" "877.0" "402.4" "530.0" "1458.3" "909.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "15" "8" "17" "8" "546" "59.2" "4.36" "3009.00" "29.49" "7" "8" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "" "VEGFA-VEGFR2 signaling; mRNA processing" "2" "0" "463.6" "390.8" "681.9" "1903.8" "846.6" "503.4" "1367.4" "459.6" "625.9" "2253.7" "1107.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "13" "7" "12" "7" "767" "86.4" "6.77" "1457.79" "29.47" "4" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "144.5" "122.9" "173.0" "496.5" "220.4" "129.2" "245.5" "117.8" "168.9" "527.9" "399.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "9" "9" "20" "9" "1176" "134.4" "7.30" "3556.34" "29.37" "9" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "440.2" "381.3" "515.5" "1459.7" "688.0" "360.3" "705.8" "408.4" "439.0" "1619.2" "1906.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "17" "7" "16" "7" "501" "57.1" "6.55" "3212.40" "29.35" "7" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Alanine and aspartate metabolism" "3" "0" "233.2" "214.0" "312.6" "1168.2" "454.5" "220.8" "408.3" "245.3" "287.1" "1596.4" "2549.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "31" "7" "15" "7" "248" "27.9" "8.46" "2949.23" "29.30" "6" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "600.0" "584.3" "727.0" "2313.1" "1034.9" "502.5" "972.5" "570.9" "639.6" "1767.7" "1482.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "29" "8" "15" "5" "249" "28.6" "4.09" "2555.81" "29.29" "7" "7" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "HuR (ELAVL1) binds and stabilizes mRNA" "IL-18 signaling pathway" "2" "0" "232.6" "239.4" "330.9" "1044.0" "422.1" "202.0" "490.4" "277.0" "263.1" "885.9" "678.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "9" "7" "11" "7" "1220" "138.7" "5.49" "1350.36" "29.25" "4" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf11987" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; Ciliary landscape" "3" "0" "431.7" "339.0" "492.3" "1384.4" "708.8" "393.2" "662.2" "349.0" "462.9" "1439.1" "1294.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18077" "60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "59" "10" "20" "10" "110" "12.5" "11.06" "3491.09" "29.09" "10" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1698.4" "1298.7" "1698.1" "3516.5" "2024.2" "1440.5" "3067.7" "1292.0" "1467.2" "4244.1" "2415.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05387" "60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "75" "5" "11" "4" "115" "11.7" "4.54" "2301.14" "28.98" "3" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "16" "1" "205.0" "240.6" "364.4" "1833.5" "494.8" "254.7" "620.5" "344.4" "381.8" "2780.4" "1927.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "14" "9" "17" "9" "669" "69.4" "9.67" "2704.66" "28.94" "8" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "RUNX2 regulates bone development" "Ciliary landscape" "2" "0" "1291.1" "1125.7" "1301.2" "1927.7" "1398.4" "1147.1" "2162.7" "1019.7" "1267.5" "2386.2" "1320.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "32" "10" "18" "10" "361" "41.5" "6.60" "3702.49" "28.80" "9" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "Anchoring of the basal body to the plasma membrane" "2q37 copy number variation syndrome" "2" "0" "647.9" "563.5" "782.5" "2912.8" "1144.9" "645.9" "1161.2" "600.7" "972.1" "3015.0" "2998.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "55" "6" "15" "6" "105" "11.7" "4.92" "2648.18" "28.57" "5" "6" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "18" "0" "453.3" "383.4" "686.9" "4621.5" "1079.7" "322.6" "927.4" "445.8" "462.8" "1439.0" "865.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "23" "8" "16" "2" "449" "49.2" "6.30" "3006.14" "28.44" "7" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; hsa:3187; P31943; Q6IBM4" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "6" "3" "474.8" "469.2" "727.9" "2837.3" "1049.9" "439.0" "1114.1" "619.1" "661.3" "2428.2" "2022.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "11" "6" "13" "6" "543" "59.3" "7.65" "1511.94" "28.36" "4" "6" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "9" "0" "249.3" "270.4" "393.6" "1772.7" "613.6" "241.9" "629.9" "352.1" "343.5" "1180.6" "1035.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "15" "9" "18" "7" "586" "69.4" "6.27" "3345.03" "28.30" "9" "7" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Netrin-1 signaling" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "11" "2" "509.2" "434.5" "629.5" "2942.9" "948.5" "381.5" "693.4" "467.1" "561.0" "2130.2" "3251.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "14" "6" "16" "1" "434" "49.7" "6.67" "3088.67" "28.29" "6" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "" "2q37 copy number variation syndrome" "1" "0" "26.8" "23.4" "33.9" "97.9" "35.7" "24.7" "38.8" "30.1" "48.2" "150.8" "144.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "28" "9" "18" "9" "338" "38.3" "5.53" "2630.17" "28.15" "7" "9" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "1" "0" "1127.7" "898.5" "1012.1" "1961.3" "1225.7" "1065.9" "1517.6" "822.3" "1001.8" "1676.5" "826.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q53GS9" "U4/U6.U5 tri-snRNP-associated protein 2 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "17" "7" "14" "7" "565" "65.3" "8.91" "2299.38" "28.09" "5" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "mRNA Splicing - Major Pathway" "" "1" "0" "125.9" "119.0" "130.5" "289.6" "158.4" "109.6" "241.4" "124.2" "159.3" "775.2" "904.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "42" "7" "17" "7" "190" "20.7" "9.54" "3401.16" "27.87" "7" "7" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "427.3" "350.2" "404.7" "828.9" "498.2" "410.5" "933.0" "416.5" "938.4" "3625.1" "3858.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969Q0" "60S ribosomal protein L36a-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "58" "10" "16" "1" "106" "12.5" "10.65" "2335.49" "27.82" "7" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "155.3" "180.4" "203.0" "360.3" "213.9" "192.9" "361.2" "185.3" "197.7" "355.2" "175.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "15" "6" "12" "6" "656" "68.4" "9.33" "1473.30" "27.82" "3" "6" "RNA metabolism OR transcription;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "" "VEGFA-VEGFR2 signaling" "1" "0" "431.9" "474.2" "482.8" "1373.1" "610.3" "400.5" "843.3" "526.4" "577.6" "1838.7" "1454.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "23" "9" "18" "9" "403" "47.3" "9.36" "2705.88" "27.81" "9" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "" "3" "0" "329.2" "271.4" "326.7" "931.6" "509.9" "296.7" "556.2" "317.9" "410.7" "2514.2" "3053.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "27" "8" "16" "8" "320" "35.9" "5.05" "2656.99" "27.78" "8" "8" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Platelet degranulation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "4" "0" "299.2" "365.8" "634.4" "3993.1" "1165.2" "211.7" "480.7" "502.5" "408.4" "1036.1" "1213.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96CX2" "BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1" "22" "6" "12" "6" "325" "35.7" "5.64" "2687.19" "27.73" "6" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02214" "115207" "ENSG00000178695" "KCTD12" "hsa:115207; Q96CX2" "" "" "0" "0" "174.7" "147.1" "195.1" "468.1" "264.5" "195.1" "258.5" "117.6" "212.2" "466.1" "813.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86YS7" "C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1" "9" "10" "16" "10" "1000" "110.4" "5.69" "3180.06" "27.69" "9" "7" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00168" "9847" "ENSG00000111731" "C2CD5" "B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "567.2" "415.3" "469.8" "823.6" "601.6" "648.1" "1886.9" "1272.9" "2210.0" "5647.6" "4002.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=2" "7" "6" "13" "6" "846" "95.0" "7.83" "2932.02" "27.60" "5" "6" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A0A0MQR1; hsa:11183; Q8IYF6; Q9Y4K4" "" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "3" "0" "333.4" "234.3" "390.1" "732.1" "516.5" "368.2" "564.0" "251.9" "686.9" "1765.7" "1576.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "20" "3" "8" "3" "264" "29.2" "5.97" "771.93" "27.46" "2" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Ub-specific processing proteases; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "177.9" "175.6" "223.3" "527.1" "285.1" "215.2" "298.1" "178.2" "200.3" "419.4" "335.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "18" "5" "14" "5" "350" "38.4" "5.12" "2793.23" "27.45" "5" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "Downregulation of TGF-beta receptor signaling" "Epithelial to mesenchymal transition in colorectal cancer" "2" "0" "557.5" "450.8" "847.8" "2722.0" "1149.7" "483.0" "1267.8" "547.5" "732.2" "1572.0" "827.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "25" "10" "21" "10" "314" "34.3" "8.85" "4089.35" "27.43" "10" "7" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "11" "0" "861.0" "884.6" "1471.3" "3044.1" "1629.2" "625.0" "1273.8" "736.7" "1176.3" "2512.9" "3637.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62888" "60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "60" "9" "23" "8" "115" "12.8" "9.63" "5055.85" "27.27" "9" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "2" "1290.7" "1181.9" "1460.2" "4013.8" "1919.7" "1003.7" "2576.7" "1207.2" "1389.2" "4891.5" "3107.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P0L0" "Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3" "24" "4" "12" "4" "249" "27.9" "8.62" "2267.09" "27.25" "4" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9218" "ENSG00000101558" "VAPA" "A6NDZ0; D3DUI3; hsa:9218; O75453; Q5U0E7; Q9P0L0; Q9UBZ2" "Neutrophil degranulation; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Sphingolipid de novo biosynthesis" "Exercise-induced circadian regulation; Cholesterol metabolism" "5" "0" "163.5" "123.0" "169.1" "623.8" "270.7" "107.2" "252.0" "162.9" "193.2" "711.0" "800.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62277" "40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "51" "10" "20" "10" "151" "17.2" "10.54" "3329.48" "27.21" "8" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1851.0" "1719.2" "1796.6" "4014.2" "2133.1" "1552.1" "3150.2" "1693.9" "1671.1" "4655.9" "3569.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "22" "8" "15" "6" "415" "45.6" "5.58" "2253.58" "27.17" "7" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; FGFR2 alternative splicing; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "MECP2 and associated Rett syndrome" "5" "2" "548.4" "506.6" "721.0" "2050.1" "897.0" "435.9" "1151.7" "590.4" "717.6" "1927.2" "1311.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "24" "6" "13" "3" "356" "37.5" "7.09" "2539.35" "26.94" "5" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "Ferroptosis" "3" "0" "118.1" "91.4" "149.2" "575.7" "200.0" "67.8" "190.0" "118.0" "136.4" "406.3" "372.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13642" "Four and a half LIM domains protein 1 OS=Homo sapiens OX=9606 GN=FHL1 PE=1 SV=4" "17" "5" "11" "5" "323" "36.2" "8.97" "1481.07" "26.86" "3" "4" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00412" "2273" "ENSG00000022267" "FHL1" "B7Z5T4; B7Z793; hsa:2273; O95212; Q13230; Q13642; Q13645; Q5JXI7; Q5M7Y6; Q6IB30; Q9NZ40; Q9UKZ8; Q9Y630" "" "Notch signaling pathway" "1" "0" "845.5" "634.9" "1341.8" "2527.6" "1078.0" "622.9" "1241.4" "793.8" "905.2" "2324.9" "1525.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "21" "4" "12" "4" "244" "28.1" "6.65" "3041.27" "26.65" "4" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "tRNA processing in the nucleus" "" "1" "0" "240.0" "238.2" "363.8" "1156.2" "507.5" "319.3" "596.7" "250.4" "350.1" "1437.2" "1077.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "54" "7" "13" "7" "199" "22.4" "8.25" "2364.05" "26.63" "6" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "Platelet degranulation" "" "1" "0" "179.1" "185.5" "346.4" "1658.6" "611.1" "175.6" "314.0" "229.8" "254.9" "457.5" "384.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "8" "6" "14" "6" "953" "105.8" "5.39" "3107.22" "26.63" "6" "6" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "538.2" "578.6" "725.4" "2042.5" "999.8" "713.5" "1018.0" "571.0" "659.3" "1489.2" "1324.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "37" "8" "13" "8" "304" "34.7" "8.53" "1884.27" "26.62" "5" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "129.3" "122.0" "188.0" "675.9" "267.7" "140.7" "275.2" "176.2" "432.6" "2854.8" "2823.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L2E3" "ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1" "9" "8" "14" "8" "1194" "133.9" "8.78" "2138.46" "26.57" "6" "8" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717" "22907" "ENSG00000132153" "DHX30" "A8K5F1; hsa:22907; O94965; Q7L2E3; Q7Z753; Q96CH4; Q9NUQ0" "" "" "0" "0" "134.1" "121.8" "159.7" "516.1" "233.3" "111.9" "279.0" "163.0" "158.5" "551.0" "436.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P1N9" "Putative deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "26" "6" "14" "6" "297" "33.6" "6.96" "1805.12" "26.42" "4" "6" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "140.1" "105.8" "185.4" "450.8" "236.9" "228.4" "236.5" "152.7" "202.5" "1067.5" "1534.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=CD3EAP PE=1 SV=1" "18" "5" "10" "5" "510" "55.0" "8.51" "1682.56" "26.33" "3" "5" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "2q13 copy number variation syndrome" "6" "0" "331.1" "266.0" "176.1" "197.2" "149.9" "98.9" "205.1" "134.8" "499.0" "2055.1" "1295.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "49" "7" "17" "7" "125" "14.3" "6.04" "3239.00" "26.28" "7" "6" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "1417.9" "909.4" "1796.6" "3456.0" "2393.0" "851.6" "1579.0" "1295.7" "1821.5" "1608.2" "1086.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "22" "8" "13" "3" "425" "47.6" "4.89" "1984.71" "26.27" "6" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "28" "5" "830.5" "724.3" "1091.9" "2920.6" "1345.9" "736.2" "1388.9" "821.9" "893.2" "2422.8" "1905.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "23" "9" "15" "9" "394" "44.7" "6.74" "2929.33" "26.25" "8" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "8" "0" "394.3" "354.4" "541.8" "1229.3" "611.5" "419.5" "771.7" "374.4" "673.2" "3464.1" "4444.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12797" "Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH PE=1 SV=3" "14" "9" "15" "9" "758" "85.8" "5.01" "3732.02" "26.16" "9" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf05118, Pf05279, Pf13432" "444" "ENSG00000198363" "ASPH" "A0A0A0MSK8; A6NDF4; A6NHI2; B4DIC9; B4E2K4; B7ZM95; E5RGP5; F5H667; hsa:444; Q12797; Q6NXR7; Q8TB28; Q9H291; Q9H2C4; Q9NRI0; Q9NRI1; Q9Y4J0" "Stimuli-sensing channels; Ion homeostasis" "" "2" "0" "311.4" "294.2" "396.8" "1192.2" "539.5" "327.8" "665.6" "346.7" "759.3" "5036.5" "5579.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "67" "11" "19" "7" "166" "18.5" "8.09" "4344.57" "26.14" "11" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "15" "4" "753.6" "812.8" "1321.4" "10605.8" "2578.4" "441.7" "1354.2" "1151.0" "867.9" "2566.6" "1987.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "40" "7" "12" "7" "239" "26.5" "7.81" "2710.20" "26.11" "6" "6" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "247.2" "272.7" "385.0" "2315.9" "697.0" "206.0" "314.6" "339.1" "303.5" "591.8" "557.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "31" "7" "11" "7" "350" "37.9" "8.73" "1285.10" "26.03" "4" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "4" "0" "302.8" "295.5" "468.6" "1501.9" "606.9" "338.5" "881.9" "426.2" "486.0" "2162.1" "1610.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "29" "5" "14" "5" "204" "22.6" "9.45" "2374.36" "26.01" "5" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "" "" "0" "0" "225.0" "227.8" "251.3" "598.9" "317.6" "209.6" "416.4" "236.9" "381.9" "1388.7" "1665.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "14" "6" "13" "6" "583" "63.4" "8.28" "2174.70" "25.99" "5" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf03483, Pf12799" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "212.1" "187.4" "235.1" "589.9" "295.5" "209.6" "361.6" "213.3" "248.0" "914.5" "1036.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "30" "9" "16" "7" "332" "36.2" "8.21" "2498.46" "25.97" "8" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "" "Pre-implantation embryo; mRNA processing" "2" "1" "981.7" "914.7" "1202.4" "3243.0" "1621.7" "908.1" "1881.7" "900.4" "908.6" "2034.7" "1092.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "47" "5" "14" "5" "127" "14.4" "9.60" "2368.55" "25.94" "4" "5" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "685.1" "561.6" "814.3" "1657.7" "978.8" "649.8" "1287.5" "1097.5" "785.8" "1520.5" "1307.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "13" "6" "14" "6" "421" "47.3" "6.84" "2433.84" "25.90" "5" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton" "5" "0" "102.4" "94.9" "134.0" "392.5" "205.6" "128.9" "247.1" "183.4" "448.5" "3458.0" "2470.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "17" "8" "16" "8" "500" "55.6" "7.18" "2914.57" "25.90" "7" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Somitogenesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Formation of paraxial mesoderm; Pre-NOTCH Transcription and Translation; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; 11p11.2 copy number variation syndrome ; Notch signaling pathway" "21" "0" "252.7" "183.6" "313.5" "637.9" "383.2" "271.3" "441.1" "259.9" "861.2" "4283.8" "4697.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "22" "8" "19" "7" "406" "46.1" "5.48" "5671.13" "25.90" "8" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "11" "1" "835.7" "876.0" "1151.4" "3720.1" "1685.5" "923.3" "1621.0" "1082.7" "1094.4" "2798.7" "2461.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "23" "9" "21" "9" "433" "48.6" "5.95" "3470.02" "25.65" "8" "7" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Separation of Sister Chromatids; Neutrophil degranulation; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; The role of GTSE1 in G2/M progression after G2 checkpoint; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "335.6" "355.9" "533.9" "2245.6" "783.6" "332.4" "824.0" "466.1" "529.4" "1754.5" "1591.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "42" "8" "20" "8" "148" "16.4" "9.95" "4798.45" "25.54" "8" "4" "RNA metabolism OR transcription;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "3241.7" "2266.8" "2547.6" "3461.5" "2907.1" "2864.3" "4262.1" "1862.3" "2990.9" "5047.9" "3507.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "21" "10" "18" "10" "531" "60.5" "9.61" "2928.57" "25.46" "9" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Hedgehog 'on' state; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "7" "0" "974.4" "727.1" "938.2" "1396.4" "1046.7" "704.9" "1423.1" "672.3" "977.8" "1968.6" "1397.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P19447" "General transcription and DNA repair factor IIH helicase subunit XPB OS=Homo sapiens OX=9606 GN=ERCC3 PE=1 SV=1" "13" "7" "12" "7" "782" "89.2" "7.23" "1500.71" "25.33" "5" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04851, Pf13625, Pf16203" "2071" "ENSG00000163161" "ERCC3" "hsa:2071; P19447; Q53QM0" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 11p11.2 copy number variation syndrome" "34" "0" "92.3" "88.3" "109.6" "288.3" "143.4" "103.2" "208.8" "236.8" "543.9" "1286.1" "857.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6GYQ0" "Ral GTPase-activating protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=RALGAPA1 PE=1 SV=1" "4" "7" "13" "7" "2036" "229.7" "6.19" "2145.19" "25.31" "6" "7" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf20412" "253959" "ENSG00000174373" "RALGAPA1" "A6NMA4; B9EK38; C5NU19; hsa:253959; O94960; Q6GYP9; Q6GYQ0; Q6ZT23; Q86YF3; Q86YF5; Q8ND69" "RHOH GTPase cycle" "" "1" "0" "36.0" "27.6" "44.7" "100.9" "56.4" "46.2" "82.9" "74.2" "148.3" "876.5" "685.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=2 SV=2" "16" "5" "11" "5" "370" "41.5" "8.18" "1492.38" "25.25" "3" "5" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs" "Pathogenic Escherichia coli infection" "6" "0" "197.4" "179.0" "255.0" "766.8" "353.5" "198.0" "364.0" "231.4" "400.9" "3480.3" "5462.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25398" "40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "48" "7" "12" "7" "132" "14.5" "7.21" "1985.45" "25.25" "4" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "760.7" "713.8" "922.4" "2501.6" "1114.1" "775.7" "1671.4" "807.1" "906.7" "3300.5" "1996.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "13" "8" "15" "8" "699" "73.6" "9.47" "2623.48" "25.22" "6" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "1373.7" "1050.9" "1414.8" "3326.1" "1873.4" "1239.7" "2090.2" "1656.4" "1409.7" "2485.1" "2292.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62266" "40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "41" "5" "14" "5" "143" "15.8" "10.49" "2585.31" "25.22" "4" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "SARS-CoV-2 modulates host translation machinery; GTP hydrolysis and joining of the 60S ribosomal subunit; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1366.8" "1029.5" "1302.6" "2373.0" "1568.2" "1116.1" "2070.4" "1091.9" "1161.6" "2350.5" "1634.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "13" "5" "13" "4" "508" "55.0" "7.06" "3322.33" "25.19" "5" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "EGF/EGFR signaling pathway" "8" "1" "302.8" "290.8" "346.9" "1038.3" "465.1" "301.8" "716.7" "356.6" "506.1" "2343.3" "1254.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "12" "8" "14" "8" "745" "85.5" "6.29" "2416.52" "25.18" "5" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "193.2" "167.0" "221.2" "567.3" "316.2" "202.1" "356.7" "294.1" "939.3" "3671.5" "2654.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P16989" "Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4" "28" "7" "14" "4" "372" "40.1" "9.77" "2373.19" "25.13" "6" "6" "stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00313" "8531" "ENSG00000060138" "YBX3" "B2RBW6; hsa:8531; P16989; Q14121; Q969N6; Q96B76" "" "RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer" "2" "0" "78.0" "68.6" "79.1" "151.8" "86.2" "67.1" "111.9" "65.6" "69.7" "164.1" "118.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "25" "6" "11" "5" "298" "33.9" "8.68" "2380.56" "25.05" "5" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "47" "0" "102.2" "83.6" "123.8" "408.0" "182.6" "103.8" "179.3" "124.1" "189.0" "1258.7" "1770.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "5" "5" "11" "5" "1576" "171.4" "8.09" "1656.16" "25.02" "4" "5" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "38.2" "33.3" "46.2" "101.0" "56.7" "49.7" "88.5" "94.6" "165.1" "434.9" "417.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "37" "6" "10" "6" "257" "26.9" "11.15" "1414.15" "24.96" "4" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript" "" "7" "0" "605.3" "461.7" "627.0" "1261.4" "720.9" "553.2" "928.4" "391.2" "510.1" "1046.4" "521.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "25" "8" "12" "8" "346" "39.2" "5.50" "2015.79" "24.96" "5" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "15" "0" "169.0" "153.1" "203.4" "549.8" "270.0" "196.1" "324.6" "260.9" "567.2" "2896.1" "2206.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "28" "4" "12" "4" "140" "15.0" "9.14" "2535.56" "24.94" "4" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "259.2" "209.9" "296.1" "1419.0" "348.4" "195.8" "343.0" "197.0" "347.1" "2264.3" "1987.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "25" "5" "9" "5" "357" "39.3" "8.10" "1935.61" "24.91" "4" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "87.4" "85.3" "128.3" "378.9" "152.7" "95.7" "248.8" "191.6" "367.0" "1797.1" "1906.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "20" "6" "15" "6" "334" "37.6" "6.54" "2242.20" "24.89" "6" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "" "4" "0" "111.0" "94.4" "153.7" "455.6" "220.6" "138.4" "359.3" "257.4" "294.8" "2437.4" "3532.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "9" "5" "14" "5" "623" "71.2" "7.37" "2672.14" "24.80" "5" "5" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "" "VEGFA-VEGFR2 signaling" "1" "0" "123.3" "116.0" "153.3" "462.2" "218.6" "139.2" "279.7" "141.2" "151.0" "497.3" "453.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "16" "7" "13" "7" "389" "44.1" "7.49" "2696.34" "24.73" "7" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "ABC-family proteins mediated transport; Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "425.9" "364.9" "542.3" "1586.1" "719.8" "420.8" "781.3" "437.6" "485.5" "1459.9" "1264.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "13" "7" "12" "7" "621" "72.0" "8.70" "1897.82" "24.73" "5" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "215.4" "216.9" "282.6" "687.0" "339.5" "190.3" "432.9" "217.6" "382.1" "2925.3" "4117.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "10" "6" "14" "6" "559" "62.9" "7.36" "2624.40" "24.61" "6" "6" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "TBC/RABGAPs" "" "1" "0" "111.9" "89.8" "148.6" "372.0" "194.4" "135.5" "307.9" "297.7" "928.3" "4156.9" "3231.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "15" "6" "8" "1" "694" "75.4" "7.66" "1463.49" "24.48" "3" "5" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "0" "5.5" "5.7" "10.3" "32.0" "18.7" "10.1" "16.6" "12.1" "11.7" "27.4" "35.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92665" "28S ribosomal protein S31, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "19" "6" "16" "6" "395" "45.3" "9.29" "2730.65" "24.35" "5" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "549.4" "457.7" "624.0" "1101.6" "742.4" "539.8" "781.5" "506.2" "727.7" "1539.1" "1437.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15293" "Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1" "21" "6" "12" "6" "331" "38.9" "5.00" "2224.24" "24.24" "4" "6" "developmental processes" "ER/Golgi" "other molecular function" "Pf13202" "5954" "ENSG00000049449" "RCN1" "B7Z1M1; D3DR00; hsa:5954; Q15293" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "VEGFA-VEGFR2 signaling" "3" "0" "983.7" "735.8" "1185.0" "3163.6" "1419.3" "731.5" "1386.7" "785.5" "1260.6" "2276.3" "1486.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60814" "Histone H2B type 1-K OS=Homo sapiens OX=9606 GN=H2BC12 PE=1 SV=3" "37" "5" "14" "5" "126" "13.9" "10.32" "2555.30" "24.23" "5" "5" "stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "85236" "ENSG00000197903" "H2BC12" "A8K7P7; hsa:85236; O60814; Q2VPI7" "Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; E3 ubiquitin ligases ubiquitinate target proteins; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HATs acetylate histones; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "" "43" "0" "455.8" "425.0" "412.7" "1111.5" "526.8" "325.7" "717.4" "483.1" "389.7" "1066.9" "839.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "15" "4" "13" "4" "282" "31.3" "4.84" "2878.79" "24.22" "4" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "8" "0" "505.8" "457.1" "607.8" "2124.6" "861.3" "419.6" "693.3" "419.1" "478.5" "1318.7" "1035.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "41" "7" "15" "7" "184" "20.8" "5.31" "2758.57" "24.16" "7" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "Pyruvate metabolism" "" "1" "0" "448.0" "548.7" "790.4" "4491.9" "1334.6" "236.0" "500.4" "602.3" "468.3" "1393.2" "1455.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "9" "6" "11" "6" "709" "78.3" "5.25" "1770.22" "24.12" "5" "6" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "205.2" "193.5" "310.2" "1300.2" "468.3" "205.0" "561.7" "255.7" "318.5" "1243.9" "1081.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "12" "6" "16" "6" "494" "56.4" "6.96" "3140.76" "24.10" "6" "6" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226, Pf13181, Pf13414, Pf13432" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Regulation of HSF1-mediated heat shock response" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "4" "0" "379.1" "343.4" "555.3" "1473.7" "746.3" "424.9" "858.8" "535.7" "559.0" "2700.8" "3170.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43719" "HIV Tat-specific factor 1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "14" "7" "12" "7" "755" "85.8" "4.40" "1735.17" "24.07" "5" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "mRNA Splicing - Major Pathway" "" "1" "0" "482.3" "427.8" "584.3" "1542.5" "741.5" "504.5" "817.3" "410.5" "510.9" "1372.5" "1077.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62899" "60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "43" "6" "16" "6" "125" "14.5" "10.54" "2418.06" "23.95" "5" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "1147.6" "950.5" "1155.2" "2326.6" "1420.7" "1144.4" "2033.2" "961.6" "1126.8" "2487.9" "1441.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "15" "6" "11" "6" "483" "53.1" "7.23" "1873.14" "23.91" "5" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "7" "0" "296.6" "236.4" "472.6" "1334.3" "576.7" "300.1" "675.3" "284.5" "498.2" "1616.4" "2311.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "28" "5" "18" "5" "193" "21.8" "6.10" "3510.97" "23.86" "5" "5" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; Hypothetical craniofacial development pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 8p23.1 copy number variation syndrome; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "70" "0" "947.1" "712.4" "1165.4" "2217.4" "1349.8" "1113.9" "1568.5" "638.5" "1014.2" "1670.1" "1190.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6W5" "Wiskott-Aldrich syndrome protein family member 2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "13" "5" "12" "4" "498" "54.3" "5.53" "2455.38" "23.80" "5" "5" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "RAC1 GTPase cycle; RAC2 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; RAC3 GTPase cycle" "Regulation of actin cytoskeleton" "8" "1" "163.3" "138.0" "175.7" "488.7" "227.4" "163.0" "341.8" "157.4" "308.6" "1101.6" "841.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase, mitochondrial OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "21" "6" "12" "6" "457" "50.2" "8.31" "2406.63" "23.71" "5" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "" "Iron-sulfur cluster biogenesis" "1" "0" "130.1" "109.7" "143.5" "306.4" "169.8" "129.6" "212.5" "172.9" "357.0" "1199.3" "1206.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15530" "3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1" "6" "2" "10" "2" "556" "63.1" "7.36" "2362.85" "23.69" "2" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf14593" "5170" "ENSG00000140992" "PDPK1" "H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5" "Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; A network map of Macrophage-stimulating protein (MSP) signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway" "46" "0" "37.3" "35.3" "53.1" "140.8" "73.7" "59.5" "113.8" "129.9" "247.8" "639.2" "633.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P29966" "Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4" "16" "4" "12" "4" "332" "31.5" "4.45" "2839.53" "23.64" "4" "4" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "4082" "ENSG00000277443" "MARCKS" "E1P560; hsa:4082; P29966; Q2LA83; Q5TDB7" "Acetylcholine regulates insulin secretion" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "2" "0" "707.3" "601.5" "797.5" "3242.0" "1274.7" "555.8" "609.8" "557.9" "540.5" "824.8" "837.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYR9" "NF-kappa-B inhibitor-interacting Ras-like protein 2 OS=Homo sapiens OX=9606 GN=NKIRAS2 PE=1 SV=1" "32" "6" "14" "6" "191" "21.5" "8.05" "2294.95" "23.64" "6" "6" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00071" "28511" "ENSG00000168256" "NKIRAS2" "A6NCZ5; B3KNN0; B4DNM3; hsa:28511; Q6PK52; Q96KC7; Q9NSX1; Q9NYR9" "RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "" "3" "0" "159.8" "156.5" "228.0" "526.5" "293.6" "222.1" "389.8" "339.2" "780.2" "3186.6" "2200.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00535" "Cyclin-dependent-like kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "24" "8" "15" "7" "292" "33.3" "7.66" "2446.82" "23.53" "7" "8" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "DARPP-32 events; NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Activated NTRK2 signals through CDK5" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "16" "1" "267.7" "236.8" "332.2" "935.9" "456.5" "393.5" "1169.2" "722.3" "1227.3" "3456.5" "3581.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75962" "Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2" "3" "5" "8" "5" "3097" "346.7" "6.37" "1133.72" "23.45" "3" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00018, Pf00069, Pf00169, Pf00435, Pf00621, Pf00650, Pf07679, Pf16609" "7204" "ENSG00000038382" "TRIO" "D3DTD1; hsa:7204; O75962; Q13458; Q59EQ7; Q6PJC9; Q6ZN05; Q8IWK8" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling" "Microtubule cytoskeleton regulation; Neural crest cell migration during development; Neural crest cell migration in cancer" "14" "0" "73.0" "83.0" "102.5" "251.9" "133.4" "104.4" "262.9" "270.0" "455.3" "1414.1" "1291.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N1I0" "Dedicator of cytokinesis protein 4 OS=Homo sapiens OX=9606 GN=DOCK4 PE=1 SV=3" "5" "8" "14" "8" "1966" "225.1" "7.65" "3216.60" "23.45" "8" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "9732" "ENSG00000128512" "DOCK4" "hsa:9732; O14584; O94824; Q8N1I0; Q8NB45" "RAC1 GTPase cycle; RAC2 GTPase cycle; Factors involved in megakaryocyte development and platelet production; RHOG GTPase cycle" "" "4" "0" "149.8" "130.6" "188.0" "441.9" "270.3" "209.7" "430.3" "342.0" "541.6" "1434.3" "1164.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "18" "5" "16" "5" "298" "33.0" "9.22" "2279.94" "23.45" "5" "5" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria" "3" "0" "326.7" "283.3" "404.6" "1479.6" "593.8" "263.9" "536.8" "302.2" "440.0" "1245.0" "1224.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "8" "11" "18" "11" "1488" "152.0" "9.04" "4527.72" "23.41" "11" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "1177.9" "1002.6" "1218.2" "2710.9" "1548.7" "953.7" "1701.5" "1505.0" "1199.7" "2677.3" "2140.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "8" "6" "13" "6" "820" "95.5" "9.55" "2316.82" "23.33" "5" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "501.5" "470.6" "604.2" "1272.1" "754.9" "561.8" "1144.5" "517.5" "750.5" "2349.6" "1890.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "28" "4" "11" "4" "201" "23.3" "5.29" "1735.54" "23.32" "3" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "Rev-mediated nuclear export of HIV RNA" "22q11.2 copy number variation syndrome" "2" "0" "509.6" "443.6" "731.4" "2865.7" "1041.7" "456.7" "851.3" "384.8" "430.7" "965.0" "691.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "17" "10" "16" "10" "528" "59.4" "4.41" "3234.23" "23.22" "9" "7" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "" "7" "0" "691.0" "610.4" "1086.4" "6215.5" "1777.8" "605.4" "1870.8" "710.7" "1148.2" "3037.9" "1535.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14185" "Dedicator of cytokinesis protein 1 OS=Homo sapiens OX=9606 GN=DOCK1 PE=1 SV=2" "4" "7" "17" "7" "1865" "215.2" "7.56" "3024.65" "23.20" "7" "6" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf06920, Pf14429, Pf16172, Pf20421, Pf20422" "1793" "ENSG00000150760" "DOCK1" "A9Z1Z5; hsa:1793; Q14185" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Regulation of actin cytoskeleton" "14" "0" "224.3" "174.2" "313.1" "821.4" "405.8" "295.9" "549.2" "350.9" "721.4" "3770.3" "3561.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "24" "6" "10" "3" "330" "37.5" "6.33" "1642.24" "23.19" "4" "6" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; DARPP-32 events" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling" "13" "3" "526.1" "457.8" "584.4" "1305.8" "732.1" "528.8" "868.9" "524.6" "577.5" "1621.4" "1422.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "10" "6" "12" "6" "586" "65.4" "8.97" "2433.79" "23.18" "6" "6" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "529.7" "418.7" "563.1" "1156.5" "631.6" "470.7" "842.0" "448.3" "583.0" "1644.1" "1466.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "35" "6" "12" "6" "184" "20.8" "5.78" "2927.92" "23.03" "6" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Ras signaling" "25" "0" "621.6" "498.2" "672.2" "1591.6" "841.3" "651.0" "1001.8" "554.4" "729.4" "1512.0" "1055.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "23" "8" "15" "8" "439" "49.2" "5.24" "4575.37" "23.01" "8" "6" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "526.5" "492.7" "703.3" "1960.5" "890.8" "545.0" "960.1" "530.7" "635.8" "1876.1" "1548.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "6" "6" "13" "6" "1091" "126.2" "6.99" "2631.22" "22.98" "5" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "239.8" "209.9" "262.8" "390.3" "277.0" "256.3" "435.4" "196.1" "298.9" "891.2" "808.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "24" "4" "10" "4" "163" "18.6" "4.54" "2324.31" "22.77" "4" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "38" "0" "150.3" "149.2" "202.9" "916.6" "302.6" "143.1" "304.7" "180.2" "240.8" "1280.7" "1189.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06746" "DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3" "34" "10" "17" "10" "335" "38.2" "8.95" "3658.29" "22.66" "9" "6" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf10391, Pf14716, Pf14791, Pf14792" "5423" "ENSG00000070501" "POLB" "B2RC78; hsa:5423; P06746; Q3KP48; Q6FI34" "Ub-specific processing proteases; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "Male infertility; Base excision repair; DNA repair pathways, full network" "10" "0" "257.4" "240.0" "328.4" "925.8" "453.4" "288.0" "564.7" "433.5" "1350.0" "5295.5" "4127.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "8" "7" "14" "7" "1031" "117.3" "9.29" "2482.86" "22.63" "7" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "mRNA Splicing - Major Pathway" "" "1" "0" "227.8" "193.7" "302.1" "899.3" "418.4" "177.2" "423.8" "255.8" "314.9" "1093.1" "1180.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase, mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "18" "4" "8" "4" "335" "36.0" "9.28" "1277.46" "22.58" "3" "4" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling" "4" "0" "213.9" "174.5" "264.0" "606.4" "333.0" "205.7" "456.4" "218.4" "265.9" "1174.6" "873.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "21" "7" "12" "6" "466" "52.1" "5.52" "1972.38" "22.43" "6" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "1" "348.2" "285.0" "388.1" "1176.0" "556.7" "310.5" "608.2" "321.2" "346.2" "994.3" "731.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "22" "5" "12" "5" "254" "28.8" "7.18" "2243.20" "22.43" "4" "5" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Cori cycle; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis" "6" "0" "429.6" "500.0" "676.1" "3520.9" "1130.5" "277.7" "447.0" "518.2" "399.8" "791.6" "818.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75521" "Enoyl-CoA delta isomerase 2, mitochondrial OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" "16" "5" "9" "5" "394" "43.6" "9.00" "1468.44" "22.30" "4" "5" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00378, Pf00887" "10455" "ENSG00000198721" "ECI2" "hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55" "" "" "0" "0" "173.6" "187.9" "264.3" "723.1" "308.8" "229.2" "550.3" "255.6" "374.6" "2986.8" "3214.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "19" "6" "11" "6" "417" "48.1" "4.44" "1524.47" "22.21" "4" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "13" "0" "304.1" "336.0" "542.7" "2706.1" "854.4" "266.6" "408.9" "371.8" "353.7" "955.1" "932.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "19" "7" "14" "4" "416" "47.3" "7.33" "2433.06" "22.19" "7" "5" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "6" "4" "281.0" "220.2" "286.9" "680.8" "384.4" "266.8" "523.6" "348.1" "805.1" "5134.2" "3207.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "13" "6" "11" "6" "609" "67.3" "6.57" "1903.64" "22.11" "5" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "OAS antiviral response" "Phosphodiesterases in neuronal function" "2" "0" "179.0" "152.9" "223.3" "663.2" "281.3" "156.1" "295.4" "193.5" "275.9" "1467.1" "2693.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62829" "60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "68" "7" "13" "7" "140" "14.9" "10.51" "2634.14" "22.08" "6" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "15" "0" "1164.9" "1012.9" "1184.3" "2885.1" "1444.3" "909.8" "2162.2" "983.9" "956.8" "2829.8" "1776.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "25" "5" "13" "5" "277" "29.9" "7.68" "2062.47" "22.04" "4" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "UCH proteinases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "750.8" "726.8" "858.6" "2018.3" "1096.9" "724.9" "1145.1" "685.7" "846.6" "1773.7" "1430.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60866" "40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "37" "4" "12" "4" "119" "13.4" "9.94" "2358.25" "22.04" "3" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "616.1" "558.4" "736.3" "1680.9" "906.9" "620.6" "1258.9" "631.3" "729.6" "1696.6" "1189.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "19" "5" "13" "2" "271" "30.5" "6.29" "1850.02" "22.04" "3" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Neutrophil degranulation" "Selenium micronutrient network" "2" "0" "10.5" "8.6" "20.7" "165.5" "39.2" "7.6" "17.2" "22.4" "14.9" "52.8" "46.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "30" "7" "11" "7" "289" "32.6" "5.86" "1626.57" "22.03" "5" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "" "2" "0" "224.3" "244.1" "385.1" "2972.9" "758.5" "201.6" "446.0" "388.3" "368.6" "1152.2" "1257.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "16" "5" "13" "5" "240" "24.6" "11.19" "1923.99" "22.02" "5" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "520.5" "504.3" "771.9" "2811.8" "1110.8" "448.1" "1334.3" "654.6" "712.0" "3190.3" "2252.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "5" "7" "13" "7" "1215" "131.3" "5.30" "2451.35" "21.97" "7" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Late endosomal microautophagy; Cilium Assembly; Aggrephagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome" "16" "0" "333.5" "291.1" "371.7" "716.7" "401.6" "313.5" "737.1" "302.3" "387.5" "1091.5" "709.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "13" "6" "13" "3" "579" "63.7" "8.87" "2597.68" "21.93" "6" "5" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "" "1" "1" "170.6" "176.6" "211.7" "680.6" "307.3" "165.7" "365.3" "198.3" "233.0" "666.8" "420.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62244" "40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "42" "7" "17" "7" "130" "14.8" "10.13" "2252.73" "21.84" "6" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1048.5" "944.2" "1114.5" "2290.8" "1353.3" "952.2" "1760.9" "895.8" "1091.5" "2804.2" "2153.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "18" "6" "12" "6" "325" "36.5" "5.64" "2159.62" "21.64" "6" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "412.7" "411.8" "448.7" "1212.0" "584.1" "373.0" "763.9" "427.6" "430.5" "1264.6" "966.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "6" "5" "10" "5" "908" "100.1" "5.20" "2067.48" "21.61" "5" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "UCH proteinases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "65" "0" "384.5" "331.0" "550.7" "2005.1" "736.1" "405.4" "780.5" "291.9" "413.9" "1432.3" "999.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "17" "7" "10" "7" "456" "52.9" "7.65" "890.04" "21.61" "3" "7" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "235.0" "207.2" "279.3" "1125.4" "412.3" "214.4" "448.5" "268.6" "275.5" "1344.0" "1497.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "39" "9" "17" "9" "215" "24.9" "5.74" "3015.51" "21.57" "8" "8" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Supression of HMGB1 mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "20" "0" "1851.1" "1407.9" "2324.7" "7115.8" "3059.4" "1262.9" "2020.5" "1343.3" "1787.8" "2759.4" "2335.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "29" "8" "15" "8" "246" "28.0" "8.44" "3277.28" "21.52" "8" "7" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "" "4" "0" "922.7" "867.0" "1348.4" "4702.8" "2031.0" "873.4" "1621.1" "1044.5" "1267.2" "2354.1" "1648.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "59" "7" "16" "7" "86" "10.1" "7.97" "3047.17" "21.50" "6" "5" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "302.4" "316.9" "337.3" "984.5" "450.5" "285.6" "500.1" "575.0" "839.9" "7121.7" "5161.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "21" "6" "11" "6" "405" "44.5" "6.70" "1828.18" "21.45" "5" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "11" "0" "190.2" "153.5" "227.2" "767.1" "305.9" "177.2" "403.2" "172.1" "192.6" "773.0" "478.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62861" "40S ribosomal protein S30 OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1" "20" "4" "14" "4" "59" "6.6" "12.15" "2457.13" "21.37" "4" "4" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;other cell component" "other molecular function" "Pf04758" "" "ENSCHIG00000017446; ENSJHYG00000000624; ENSLLEG00000000574" "Fau; FAU" "A0A452F0A8; A0A7L0YXB0; A0A8C5IE60; A0A8C5LQJ8; P0C2F0; P62860; P62863; P62864; P62866; P62867; Q05472; Q5RC12; Q8HYI8; Q920W7; Q95261" "" "" "0" "0" "718.0" "679.5" "683.5" "1225.8" "735.7" "612.7" "1118.3" "673.6" "629.3" "1541.1" "1310.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "16" "4" "9" "3" "297" "34.1" "8.40" "1998.30" "21.35" "3" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; ATM signaling in development and disease ; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "49" "0" "180.5" "166.2" "201.5" "522.1" "252.3" "182.5" "341.0" "220.6" "260.4" "859.5" "992.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "3" "5" "10" "5" "2472" "284.4" "5.35" "2253.91" "21.30" "5" "5" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Neutrophil degranulation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins" "Fas ligand pathway and stress induction of heat shock proteins" "12" "0" "163.6" "136.8" "210.9" "706.9" "309.1" "151.3" "281.0" "173.9" "194.1" "1017.8" "1613.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15283" "Ras GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RASA2 PE=1 SV=3" "10" "8" "16" "8" "850" "96.6" "7.20" "3261.80" "21.29" "7" "5" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "5922" "ENSG00000155903" "RASA2" "A8K7K1; G3V0F9; hsa:5922; O00695; Q15283; Q15284; Q92594; Q99577; Q9UEQ2" "Regulation of RAS by GAPs" "MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation" "5" "0" "87.2" "75.7" "116.1" "289.7" "143.4" "122.8" "279.4" "463.4" "1165.5" "2617.7" "1327.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "15" "5" "11" "5" "517" "58.2" "7.49" "1941.64" "21.23" "4" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "TP53 Regulates Transcription of DNA Repair Genes; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM" "" "32" "0" "67.9" "76.1" "84.5" "241.9" "115.7" "72.3" "133.1" "131.1" "149.4" "686.9" "766.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "22" "6" "11" "6" "363" "39.7" "8.02" "1711.13" "21.17" "5" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Polymerase switching on the C-strand of the telomere; Polymerase switching; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "303.6" "287.2" "370.3" "1113.6" "526.4" "315.3" "605.3" "384.6" "537.1" "1710.1" "1494.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "17" "7" "14" "7" "463" "51.1" "5.64" "2246.18" "21.15" "7" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "HATs acetylate histones; Telomere Extension By Telomerase" "" "2" "0" "283.3" "301.5" "340.9" "1282.4" "526.2" "249.7" "433.0" "318.8" "324.4" "1027.0" "983.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "24" "5" "8" "5" "216" "24.4" "7.49" "1194.14" "21.13" "3" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Transcriptional regulation by small RNAs; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "11" "0" "330.9" "338.3" "564.4" "2380.4" "854.9" "328.7" "525.0" "386.4" "346.2" "759.0" "673.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "13" "6" "12" "1" "425" "47.8" "5.05" "2505.84" "21.01" "5" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "Transcriptional Regulation by E2F6; HCMV Early Events; Neddylation; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Regulation of PTEN gene transcription; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome" "20" "0" "262.8" "250.1" "280.3" "517.4" "291.1" "213.8" "383.5" "249.2" "234.8" "359.9" "234.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "12" "6" "12" "6" "486" "55.7" "5.20" "2233.34" "20.97" "6" "6" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00611" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "Clathrin-mediated endocytosis" "" "1" "0" "306.7" "276.0" "372.1" "1068.8" "470.3" "266.6" "484.9" "280.0" "557.5" "3218.5" "3303.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "9" "4" "8" "3" "765" "86.1" "7.08" "1298.06" "20.77" "2" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "1" "214.5" "184.9" "243.1" "672.2" "307.8" "216.1" "299.5" "183.6" "224.2" "534.4" "421.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "4" "6" "11" "5" "1912" "217.9" "5.86" "1934.26" "20.74" "5" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "hsa:1108; Q14839; Q8IXZ5" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "Rett syndrome causing genes; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome" "9" "1" "439.7" "383.9" "580.4" "1659.2" "799.6" "409.1" "736.5" "453.5" "551.5" "1164.6" "973.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPT5" "Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3" "5" "3" "11" "3" "735" "83.3" "6.79" "2137.84" "20.72" "3" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03081" "23265" "ENSG00000182473" "EXOC7" "B5MC69; B8XXP2; hsa:23265; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32; Q9UPT5" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Angiopoietin-like protein 8 regulatory pathway; Ciliary landscape" "5" "0" "58.1" "45.0" "77.2" "178.9" "102.0" "62.7" "114.7" "96.4" "180.7" "1212.1" "1146.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P158" "Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2" "4" "5" "9" "3" "1386" "155.5" "7.71" "1611.86" "20.69" "4" "5" "" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf05773, Pf07717, Pf18044" "90957" "ENSG00000163214" "DHX57" "A2RRC7; hsa:90957; Q53SI4; Q6P158; Q6P9G1; Q7Z6H3; Q8NG17; Q96M33" "" "" "0" "0" "51.2" "48.4" "77.4" "255.9" "120.2" "78.0" "144.2" "69.7" "99.8" "326.3" "233.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "11" "4" "10" "4" "499" "56.8" "6.28" "1869.99" "20.62" "4" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "MAPK signaling pathway; ATM signaling in development and disease" "5" "0" "120.6" "113.7" "181.8" "684.3" "277.1" "138.4" "192.6" "162.1" "225.9" "894.0" "1908.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01081" "Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3" "13" "2" "9" "2" "240" "27.9" "8.81" "1659.83" "20.51" "2" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "102724594; 7307" "ENSG00000160201" "U2AF1" "hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "mRNA processing" "5" "0" "68.7" "71.6" "100.4" "363.4" "151.5" "85.1" "180.6" "134.2" "125.8" "497.9" "584.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "11" "8" "14" "6" "839" "94.5" "5.88" "1910.67" "20.50" "5" "7" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "163.2" "166.0" "251.5" "884.4" "351.4" "157.1" "336.6" "213.7" "237.6" "797.6" "661.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "34" "6" "11" "6" "192" "22.0" "5.73" "1817.38" "20.43" "5" "6" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "hsa:10654; Q15126; Q5TZW9" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "198.8" "229.0" "234.6" "757.9" "312.3" "174.5" "301.2" "224.6" "317.7" "1919.4" "3896.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "31" "7" "10" "7" "261" "28.8" "4.69" "1359.89" "20.39" "4" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "HDR through Homologous Recombination (HRR); E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; A network map of Macrophage-stimulating protein (MSP) signaling" "45" "0" "410.2" "463.4" "686.9" "4157.8" "1172.8" "267.8" "774.1" "580.8" "547.2" "1604.3" "1417.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "23" "5" "14" "5" "115" "12.5" "7.88" "3255.81" "20.38" "5" "4" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Adipogenesis; Spinal cord injury" "5" "0" "441.6" "508.4" "955.3" "4368.7" "1623.9" "448.6" "584.4" "734.3" "522.7" "799.8" "778.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "19" "7" "14" "7" "369" "41.3" "5.27" "2231.57" "20.34" "6" "7" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "757.1" "641.8" "986.5" "4067.3" "1242.5" "528.0" "1432.6" "668.1" "946.3" "2865.1" "2329.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95239" "Chromosome-associated kinesin KIF4A OS=Homo sapiens OX=9606 GN=KIF4A PE=1 SV=3" "8" "8" "13" "8" "1232" "139.8" "6.27" "2359.44" "20.30" "7" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "24137" "ENSG00000090889" "KIF4A" "B2R7V5; D3DVU4; hsa:24137; O95239; Q86TN3; Q86XX7; Q9NNY6; Q9NY24; Q9UMW3" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "Retinoblastoma gene in cancer" "5" "0" "237.0" "210.6" "258.0" "547.8" "342.3" "256.8" "470.4" "224.6" "300.3" "784.6" "552.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43427" "Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3" "20" "7" "13" "7" "364" "41.9" "6.48" "2525.69" "20.29" "7" "6" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05427" "9158" "ENSG00000172500" "FIBP" "A8K0J7; hsa:9158; O43427; Q27Q85; Q6IBQ3; Q9HD65" "" "Modulators of TCR signaling and T cell activation" "1" "0" "199.6" "172.4" "234.8" "600.3" "300.8" "332.7" "1146.6" "786.3" "1480.6" "3432.2" "2362.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "9" "3" "8" "3" "514" "57.6" "9.42" "2087.48" "20.29" "3" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "108.8" "108.8" "145.8" "437.5" "202.3" "119.8" "262.7" "133.3" "182.9" "1562.1" "1504.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H3P2" "Negative elongation factor A OS=Homo sapiens OX=9606 GN=NELFA PE=1 SV=3" "10" "4" "12" "4" "528" "57.2" "9.03" "2263.22" "20.28" "3" "3" "other biological processes" "cytosol;nucleus" "other molecular function" "" "7469" "ENSG00000185049" "NELFA" "A2A2T1; hsa:7469; O95392; Q9H3P2" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR" "15" "0" "205.6" "156.1" "235.7" "490.6" "326.4" "203.0" "315.5" "221.0" "269.1" "467.9" "385.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "16" "6" "11" "5" "375" "42.8" "4.69" "1552.74" "20.27" "5" "6" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "0" "147.3" "144.8" "234.4" "794.0" "299.4" "152.0" "326.2" "204.0" "230.8" "708.0" "587.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "7" "6" "9" "6" "1153" "130.1" "8.48" "1062.66" "20.18" "3" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "hsa:8943; O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "147.6" "112.4" "175.9" "402.8" "229.6" "148.4" "259.3" "129.0" "213.7" "1673.2" "1704.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "24" "4" "13" "4" "178" "20.5" "8.59" "2565.35" "20.12" "4" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "303.0" "252.9" "343.1" "870.8" "446.3" "279.1" "503.2" "327.9" "588.2" "3745.2" "5080.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96RF0" "Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2" "12" "5" "9" "5" "628" "68.9" "5.68" "1516.07" "19.98" "3" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf10456, Pf14604" "112574" "ENSG00000178996" "SNX18" "B4E2B3; H7BXX3; hsa:112574; Q05BB3; Q0VG02; Q96RF0" "Clathrin-mediated endocytosis" "" "1" "0" "284.3" "222.6" "318.6" "657.1" "407.7" "296.9" "472.5" "428.5" "2005.2" "4437.4" "1750.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "13" "7" "12" "7" "639" "68.3" "8.98" "2049.84" "19.95" "6" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "mRNA Splicing - Major Pathway" "" "1" "0" "682.1" "582.2" "689.0" "1483.3" "878.7" "502.2" "923.8" "471.7" "696.6" "1418.5" "1232.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "37" "6" "10" "6" "198" "22.1" "5.30" "1570.65" "19.88" "5" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "434.0" "352.4" "520.0" "1185.1" "639.5" "386.7" "654.7" "321.6" "576.7" "1933.8" "2858.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "42" "7" "13" "7" "181" "20.6" "8.87" "3526.52" "19.87" "7" "5" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "Neutrophil degranulation" "" "1" "0" "1264.8" "932.0" "1192.3" "2492.2" "1435.7" "964.0" "1915.2" "776.7" "1136.5" "2336.4" "1312.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "57" "6" "13" "6" "118" "13.5" "9.91" "3182.10" "19.78" "5" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "500.8" "445.9" "697.7" "1858.1" "889.1" "472.7" "1015.3" "447.5" "580.5" "1607.4" "1102.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q709F0" "Acyl-CoA dehydrogenase family member 11 OS=Homo sapiens OX=9606 GN=ACAD11 PE=1 SV=3" "8" "5" "10" "5" "780" "87.2" "8.02" "1986.42" "19.74" "5" "5" "other metabolic processes" "other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00441, Pf01636, Pf02770, Pf02771" "84129" "ENSG00000240303" "ACAD11" "hsa:84129; Q08AF0; Q658N9; Q658Y2; Q6ZND2; Q709F0; Q8WUT6; Q9H9R3" "Mitochondrial Fatty Acid Beta-Oxidation" "p53 transcriptional gene network" "2" "0" "127.0" "116.6" "148.6" "406.5" "207.0" "130.3" "235.1" "126.2" "204.4" "1783.5" "1839.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "4" "9" "16" "9" "2136" "244.4" "6.06" "2889.88" "19.67" "9" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2q11.2 copy number variation syndrome" "3" "0" "592.4" "530.0" "685.1" "1520.3" "837.9" "575.0" "1079.8" "561.9" "687.4" "2602.5" "2495.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63173" "60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "47" "5" "16" "4" "70" "8.2" "10.10" "2291.17" "19.66" "5" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "GTP hydrolysis and joining of the 60S ribosomal subunit; L13a-mediated translational silencing of Ceruloplasmin expression; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "16" "2" "1371.6" "1114.9" "1052.0" "1531.4" "1212.8" "899.8" "1534.6" "1239.9" "1382.1" "2834.3" "3075.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "31" "4" "8" "4" "248" "27.4" "7.23" "1082.05" "19.66" "2" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "Translation factors; 7q11.23 copy number variation syndrome" "7" "0" "203.5" "199.2" "288.6" "1070.7" "442.0" "147.7" "201.7" "262.9" "202.2" "287.4" "300.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NFJ9" "Bardet-Biedl syndrome 1 protein OS=Homo sapiens OX=9606 GN=BBS1 PE=1 SV=1" "15" "6" "11" "6" "593" "65.0" "7.93" "2148.84" "19.64" "6" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf14779" "582" "ENSG00000174483" "BBS1" "hsa:582; Q32MM9; Q32MN0; Q8NFJ9; Q96SN4" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "103.3" "113.7" "122.9" "290.1" "142.9" "105.3" "180.9" "134.9" "270.4" "1257.0" "1064.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "19" "5" "10" "5" "275" "30.3" "8.22" "1986.01" "19.61" "5" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Neddylation" "Ciliary landscape" "5" "0" "70.3" "75.2" "103.3" "313.8" "143.5" "89.3" "412.4" "208.9" "258.7" "1250.7" "1879.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "6" "9" "15" "5" "1976" "228.9" "5.54" "3300.96" "19.55" "8" "6" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "EPHA-mediated growth cone collapse; RHO GTPases activate PAKs; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs" "Regulation of actin cytoskeleton" "7" "0" "136.7" "147.3" "172.6" "630.0" "262.2" "120.3" "219.8" "149.6" "153.9" "402.2" "457.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L7X3" "Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1" "4" "4" "10" "2" "1001" "116.0" "7.65" "2049.83" "19.55" "4" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "57551" "ENSG00000160551" "TAOK1" "A2RUT8; B7ZLV6; hsa:57551; Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; MAPK signaling pathway" "8" "0" "72.4" "57.4" "71.4" "180.5" "93.4" "68.5" "125.8" "107.3" "138.1" "490.2" "495.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62910" "60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "40" "5" "13" "5" "135" "15.9" "11.33" "2366.17" "19.54" "5" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "SRP-dependent cotranslational protein targeting to membrane; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "722.4" "654.6" "694.8" "1803.6" "874.1" "583.2" "1428.4" "699.3" "764.0" "2374.0" "1391.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14527" "Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2" "7" "4" "9" "4" "1009" "113.9" "8.60" "1475.92" "19.52" "3" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf08797, Pf13923" "6596" "ENSG00000071794" "HLTF" "D3DNH3; hsa:6596; Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9" "E3 ubiquitin ligases ubiquitinate target proteins" "Retinoblastoma gene in cancer" "2" "0" "52.6" "56.8" "74.4" "159.7" "96.9" "68.5" "136.8" "67.7" "78.1" "261.4" "227.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92804" "TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1" "14" "6" "11" "3" "592" "61.8" "8.02" "1659.41" "19.45" "4" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "8148" "ENSG00000270647; ENSG00000276833" "TAF15" "B2R837; hsa:8148; Q86X94; Q92751; Q92804" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "17q12 copy number variation syndrome" "10" "0" "127.6" "89.3" "140.4" "419.5" "188.7" "88.1" "196.6" "107.3" "145.4" "470.4" "371.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "14" "5" "9" "5" "529" "57.8" "5.40" "1463.10" "19.36" "4" "5" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "" "8" "0" "110.4" "124.1" "191.0" "651.5" "249.9" "158.5" "278.3" "171.8" "238.8" "968.8" "776.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "24" "5" "12" "5" "210" "23.7" "6.42" "2402.52" "19.27" "5" "5" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1198.0" "813.0" "1353.0" "1846.9" "1479.5" "886.4" "1682.9" "897.6" "1382.5" "1940.9" "1622.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "6" "7" "12" "7" "1357" "156.2" "5.64" "2726.67" "19.18" "7" "5" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND3 GTPase cycle; RHOG GTPase cycle; RHO GTPases activate KTN1" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "11" "0" "243.7" "244.0" "326.4" "1138.6" "468.9" "269.6" "486.6" "236.8" "420.5" "1184.3" "1005.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "33" "7" "15" "7" "218" "24.6" "6.68" "2581.01" "19.02" "7" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "Mesodermal commitment pathway" "4" "0" "289.9" "285.8" "469.5" "2084.4" "736.7" "216.0" "557.0" "331.8" "289.3" "1205.8" "1247.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "14" "4" "10" "3" "356" "39.4" "7.20" "2304.90" "19.00" "4" "4" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "161.8" "142.8" "173.1" "485.6" "239.4" "181.5" "307.1" "166.7" "333.5" "1577.7" "1736.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63220" "40S ribosomal protein S21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "57" "6" "14" "6" "83" "9.1" "8.50" "2503.96" "18.98" "6" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1167.4" "963.3" "1070.8" "2284.3" "1268.1" "977.4" "1849.8" "787.0" "1024.2" "2556.1" "1489.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "12" "6" "13" "6" "558" "63.1" "8.32" "2789.80" "18.92" "6" "5" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "TP53 Regulates Metabolic Genes; Glycolysis; Gluconeogenesis; Neutrophil degranulation" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; UDP-derived sugars synthesis in fibroblasts" "12" "0" "629.4" "695.0" "1088.5" "5132.1" "1877.3" "439.2" "759.4" "865.7" "778.3" "1735.9" "2177.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "21" "6" "11" "6" "334" "36.6" "8.27" "2105.94" "18.90" "6" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RMTs methylate histone arginines; Neddylation; Formation of WDR5-containing histone-modifying complexes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "Pleural mesothelioma; Kleefstra syndrome" "10" "0" "347.3" "331.7" "435.6" "899.3" "504.9" "344.9" "798.3" "349.3" "433.8" "1487.2" "1410.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "21" "5" "10" "5" "225" "26.1" "5.66" "1873.19" "18.87" "5" "5" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "mRNA Splicing - Major Pathway" "" "1" "0" "61.8" "60.1" "90.2" "214.8" "119.7" "75.8" "124.7" "70.8" "127.5" "1384.1" "1641.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "53" "5" "9" "5" "108" "12.8" "5.29" "1946.07" "18.74" "4" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "Post-chaperonin tubulin folding pathway" "VEGFA-VEGFR2 signaling" "2" "0" "286.2" "336.9" "572.3" "3470.0" "1049.1" "208.6" "344.8" "351.0" "295.3" "484.6" "432.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "4" "6" "11" "5" "2002" "224.2" "5.55" "2209.66" "18.71" "6" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; hsa:57553; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "1" "66.2" "63.2" "104.5" "206.4" "133.2" "93.2" "176.9" "195.4" "253.3" "1492.4" "1185.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P84098" "60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1" "27" "9" "16" "8" "196" "23.5" "11.47" "4514.47" "18.68" "8" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01280" "6143" "ENSG00000108298" "RPL19" "B2R4K2; hsa:6143; P14118; P22908; P84098; Q502Y6; Q7Z6E4" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1086.3" "1013.3" "1020.2" "2166.4" "1222.5" "974.3" "1768.3" "1017.8" "994.7" "2330.2" "1401.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "31" "5" "10" "5" "219" "24.3" "4.94" "2094.28" "18.68" "4" "4" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "Phosphate bond hydrolysis by NUDT proteins" "10q11.21q11.23 copy number variation syndrome" "2" "0" "263.0" "255.5" "365.2" "1301.9" "568.8" "289.1" "573.3" "274.6" "394.3" "879.7" "607.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "8" "7" "12" "7" "913" "101.3" "5.45" "2201.68" "18.65" "6" "6" "" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "" "Ectoderm differentiation" "1" "0" "227.1" "213.6" "309.8" "788.3" "455.2" "356.8" "742.5" "715.7" "1289.9" "2529.2" "1643.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "6" "4" "11" "4" "665" "75.7" "6.84" "2088.50" "18.59" "4" "4" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13176, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "96.7" "103.4" "174.4" "430.3" "218.3" "133.3" "255.0" "144.1" "196.2" "799.5" "961.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "13" "5" "10" "2" "406" "46.2" "6.99" "1609.54" "18.59" "4" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Synthesis of PIPs at the plasma membrane; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton; G13 signaling pathway" "6" "0" "31.5" "25.2" "36.9" "68.6" "49.6" "35.7" "49.6" "46.8" "115.1" "587.8" "335.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "9" "8" "14" "8" "1096" "123.4" "8.82" "2873.57" "18.57" "8" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "4" "0" "681.0" "547.3" "759.2" "1888.3" "952.3" "703.7" "1274.4" "530.1" "672.2" "1992.4" "1255.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "21" "5" "8" "2" "323" "37.0" "6.54" "1207.94" "18.55" "3" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Downregulation of TGF-beta receptor signaling; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "16" "0" "241.2" "198.0" "253.3" "502.4" "303.4" "209.6" "368.1" "184.9" "225.8" "609.8" "524.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NCA5" "Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2" "11" "5" "11" "3" "518" "55.2" "8.95" "2342.46" "18.44" "5" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "25940" "ENSG00000119812" "FAM98A" "B2RNA2; hsa:25940; Q8NCA5; Q9Y3Y6" "" "" "0" "0" "97.8" "86.1" "116.2" "334.1" "161.0" "88.7" "164.0" "117.2" "145.7" "445.5" "345.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "25" "5" "13" "5" "268" "30.0" "5.14" "2230.26" "18.42" "4" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; The role of GTSE1 in G2/M progression after G2 checkpoint" "Microtubule cytoskeleton regulation" "15" "0" "196.1" "188.3" "288.8" "981.8" "395.4" "190.1" "283.7" "214.0" "275.0" "609.6" "522.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "6" "5" "10" "5" "1304" "145.7" "7.09" "1914.23" "18.40" "5" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "4" "0" "175.0" "165.2" "210.3" "501.9" "301.2" "179.9" "341.8" "171.6" "204.9" "437.9" "309.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "8" "6" "9" "6" "856" "95.7" "6.92" "1039.37" "18.39" "3" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "523.5" "437.2" "590.8" "1478.2" "804.5" "501.9" "783.1" "381.8" "526.8" "1174.3" "730.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12235" "ADP/ATP translocase 1 OS=Homo sapiens OX=9606 GN=SLC25A4 PE=1 SV=4" "24" "7" "12" "1" "298" "33.0" "9.76" "2196.96" "18.31" "6" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "transporter activity" "Pf00153" "291" "ENSG00000151729" "SLC25A4" "D3DP59; hsa:291; P12235" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Mitochondrial protein import; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Synaptic vesicle pathway; Alzheimer's disease; Sudden infant death syndrome (SIDS) susceptibility pathways" "8" "0" "37.3" "35.7" "51.1" "144.4" "60.0" "35.6" "62.6" "40.1" "53.6" "139.1" "96.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75689" "Arf-GAP with dual PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ADAP1 PE=1 SV=2" "17" "5" "10" "5" "374" "43.4" "8.97" "1903.60" "18.30" "5" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412" "11033" "ENSG00000105963" "ADAP1" "A4D2Q2; B3KRZ4; B4DVA6; F6XZ68; H7C2Q4; hsa:11033; O75689" "Nuclear signaling by ERBB4" "" "1" "0" "147.2" "125.7" "185.5" "418.2" "222.3" "181.6" "339.4" "360.5" "1016.1" "2241.0" "1655.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "16" "6" "10" "6" "375" "42.6" "8.56" "1362.44" "18.29" "4" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "IL-18 signaling pathway" "4" "0" "534.1" "463.9" "611.4" "1450.3" "784.6" "434.2" "868.9" "530.5" "583.2" "1568.2" "1984.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "17" "6" "11" "6" "393" "44.9" "8.63" "2066.79" "18.28" "5" "4" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "Platelet degranulation" "" "1" "0" "493.3" "364.5" "433.6" "869.5" "518.4" "462.3" "811.5" "350.7" "669.4" "3546.6" "3594.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02809" "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2" "9" "5" "10" "5" "727" "83.5" "6.95" "1847.86" "18.25" "5" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03171" "5351" "ENSG00000083444" "PLOD1" "B4DR87; hsa:5351; Q02809; Q96AV9; Q9H132" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "56.9" "70.5" "96.6" "243.9" "122.9" "78.7" "144.6" "86.5" "101.5" "393.2" "364.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42677" "40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "39" "4" "12" "4" "84" "9.5" "9.45" "1863.49" "18.25" "4" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins; 11p11.2 copy number variation syndrome" "26" "0" "611.7" "600.2" "705.4" "1430.1" "808.8" "603.6" "1184.3" "652.7" "644.6" "1583.1" "1207.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "12" "5" "8" "5" "536" "61.5" "9.52" "1608.98" "18.21" "4" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "mRNA Splicing - Major Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of paraxial mesoderm; Pre-NOTCH Transcription and Translation; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "15" "0" "314.8" "274.3" "337.0" "735.2" "431.7" "304.1" "492.3" "313.9" "359.9" "846.2" "636.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "13" "5" "7" "5" "644" "74.4" "5.53" "1323.78" "18.21" "3" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "164.1" "157.0" "245.5" "666.8" "324.2" "173.2" "456.9" "201.1" "216.2" "574.4" "335.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "30" "6" "11" "6" "129" "13.7" "8.81" "2448.67" "17.99" "6" "5" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly" "6" "0" "469.9" "420.6" "594.9" "2642.9" "924.1" "401.8" "631.0" "528.3" "526.4" "1081.2" "1128.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "10" "3" "8" "3" "445" "50.6" "6.47" "1941.33" "17.96" "3" "3" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "" "2" "0" "134.7" "118.1" "188.7" "1195.5" "316.5" "90.9" "164.2" "148.2" "158.1" "341.6" "422.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "5" "2" "6" "2" "509" "54.8" "5.59" "902.39" "17.95" "1" "2" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway" "2" "0" "73.3" "72.8" "110.3" "304.6" "160.1" "88.2" "183.7" "87.5" "146.2" "1051.0" "1402.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "40" "12" "19" "4" "219" "21.9" "11.03" "4402.45" "17.94" "11" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Pathways affected in adenoid cystic carcinoma" "3" "9" "1938.0" "1640.3" "2058.1" "4316.6" "2439.2" "1763.1" "3294.8" "1235.2" "1749.6" "4159.9" "2261.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "33" "5" "9" "5" "167" "18.8" "8.95" "1220.85" "17.93" "4" "5" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "287.6" "222.1" "291.4" "620.3" "345.9" "270.9" "419.2" "213.4" "331.9" "918.1" "825.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "10" "5" "10" "4" "589" "64.1" "8.22" "2067.88" "17.86" "5" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; Hippocampal synaptogenesis and neurogenesis; 11p11.2 copy number variation syndrome" "5" "1" "513.3" "454.7" "539.5" "1438.5" "658.4" "453.4" "858.7" "390.8" "458.0" "1259.4" "810.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNX4" "WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1" "6" "4" "7" "4" "943" "106.0" "6.64" "1182.77" "17.86" "3" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf04003, Pf12894" "10885" "ENSG00000065183" "WDR3" "hsa:10885; Q9UNX4" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "42.9" "48.4" "54.1" "146.0" "75.9" "51.8" "84.2" "50.4" "99.8" "640.7" "578.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "17" "5" "9" "5" "352" "39.9" "6.54" "1845.51" "17.76" "4" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "10" "0" "436.9" "377.8" "507.1" "1203.9" "612.5" "378.1" "758.4" "341.3" "431.3" "1423.5" "941.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "22" "4" "8" "4" "302" "33.8" "6.67" "1195.08" "17.72" "3" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "107.9" "98.8" "147.6" "354.6" "184.5" "135.3" "432.4" "135.8" "323.5" "2013.9" "2148.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "25" "3" "9" "3" "150" "17.1" "4.68" "2003.98" "17.67" "3" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "83.3" "99.2" "109.1" "367.9" "165.0" "79.5" "211.4" "189.0" "611.4" "3403.4" "2490.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPQ3" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=AGAP1 PE=1 SV=4" "7" "4" "9" "4" "857" "94.4" "7.94" "1325.00" "17.63" "3" "4" "transport;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf00071, Pf01412, Pf12796" "116987" "ENSG00000157985" "AGAP1" "B2RTX7; hsa:116987; Q541S5; Q6P9D7; Q9NV93; Q9UPQ3" "" "2q37 copy number variation syndrome" "1" "0" "67.4" "51.6" "77.3" "180.9" "105.1" "71.9" "119.2" "100.4" "220.6" "796.7" "660.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43491" "Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1" "7" "7" "12" "6" "1005" "112.5" "5.44" "1845.02" "17.55" "6" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2037" "ENSG00000079819" "EPB41L2" "B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2" "Neurexins and neuroligins" "Splicing factor NOVA regulated synaptic proteins" "2" "1" "153.4" "144.2" "192.5" "546.2" "275.6" "157.7" "260.8" "199.2" "333.7" "2260.8" "1448.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62917" "60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "16" "8" "15" "8" "257" "28.0" "11.03" "2748.22" "17.49" "8" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "2535.1" "2285.3" "2450.9" "4863.2" "2814.4" "2094.4" "4479.0" "1899.0" "2077.8" "4633.2" "2345.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "37" "4" "8" "4" "181" "20.5" "8.82" "1886.06" "17.49" "4" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119; ENSG00000288295" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "0" "36.5" "35.1" "55.3" "165.3" "66.4" "33.6" "66.8" "58.7" "65.3" "259.8" "634.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "5" "4" "10" "4" "906" "102.4" "5.27" "2134.67" "17.47" "4" "4" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "284.4" "256.8" "338.4" "808.2" "423.5" "307.7" "604.3" "281.3" "315.8" "1051.4" "787.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "8" "5" "10" "5" "719" "81.3" "6.46" "1967.59" "17.46" "5" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication; 10q11.21q11.23 copy number variation syndrome" "13" "0" "193.1" "190.8" "224.6" "729.8" "296.7" "166.3" "276.9" "187.4" "198.2" "612.1" "595.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "8" "5" "11" "5" "783" "87.3" "9.28" "2086.45" "17.46" "5" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "423.8" "333.2" "493.6" "1116.0" "607.2" "388.0" "815.0" "315.4" "471.7" "1580.6" "1033.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14602" "Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AY PE=1 SV=4" "47" "4" "7" "4" "144" "16.4" "5.24" "1531.29" "17.27" "3" "4" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01176" "9086" "ENSG00000198692" "EIF1AY" "hsa:9086; O14602; Q9BS77" "" "Translation factors" "1" "0" "490.7" "426.0" "502.3" "1790.3" "677.9" "384.0" "752.0" "442.2" "615.3" "1858.4" "1301.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "10" "4" "6" "4" "739" "83.1" "7.03" "892.38" "17.23" "2" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "2" "0" "114.2" "102.7" "219.9" "1026.9" "343.3" "107.9" "200.5" "181.7" "167.0" "363.2" "425.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92599" "Septin-8 OS=Homo sapiens OX=9606 GN=SEPTIN8 PE=1 SV=4" "7" "4" "10" "1" "483" "55.7" "6.28" "1351.72" "17.22" "3" "4" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23176" "ENSG00000164402" "SEPTIN8" "A6NC65; A6NKP6; F6W7K9; hsa:23176; Q8IX36; Q8IX37; Q92599; Q9BVB3" "" "22q11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "20" "3" "8" "3" "218" "25.0" "4.93" "1789.84" "17.11" "3" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "" "6" "0" "127.2" "164.4" "198.7" "588.8" "261.8" "149.1" "316.3" "193.0" "204.0" "1046.1" "921.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "18" "5" "7" "5" "357" "41.4" "8.78" "1283.73" "17.10" "3" "4" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "" "Cholesterol metabolism" "1" "0" "172.9" "128.5" "192.1" "483.9" "241.9" "167.2" "311.0" "152.5" "421.0" "2151.8" "1536.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "18" "6" "14" "6" "451" "51.1" "6.14" "3031.46" "17.08" "5" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Alstrom syndrome" "8" "0" "253.9" "229.1" "347.4" "755.1" "430.3" "287.2" "532.4" "347.4" "728.4" "3451.4" "3411.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6M1" "Insulin-like growth factor 2 mRNA-binding protein 2 OS=Homo sapiens OX=9606 GN=IGF2BP2 PE=1 SV=2" "9" "3" "7" "1" "599" "66.1" "8.46" "1294.52" "17.07" "2" "3" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10644" "ENSG00000073792" "IGF2BP2" "A0A4Z0; B3FTN2; B3FTN3; B3FTN4; hsa:10644; Q9Y6M1" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "" "1" "0" "16.1" "20.6" "14.5" "46.9" "21.1" "17.2" "30.9" "29.8" "19.0" "108.9" "77.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94832" "Unconventional myosin-Id OS=Homo sapiens OX=9606 GN=MYO1D PE=1 SV=2" "5" "5" "9" "5" "1006" "116.1" "9.39" "1644.56" "17.05" "4" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4642" "ENSG00000176658" "MYO1D" "A6H8V3; hsa:4642; O94832; Q8NHP9" "" "" "0" "0" "76.8" "68.6" "117.3" "373.6" "160.1" "106.9" "173.6" "124.6" "261.4" "1158.2" "842.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13825" "Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1" "18" "5" "10" "5" "339" "35.6" "9.48" "1956.72" "16.99" "5" "5" "other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00378" "549" "ENSG00000148090" "AUH" "B1ALV7; B1ALV8; hsa:549; Q13825; Q8WUE4" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "241.9" "224.0" "256.1" "612.9" "333.5" "218.2" "443.3" "268.8" "526.9" "2577.4" "2402.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "32" "5" "7" "5" "209" "23.4" "8.24" "1060.59" "16.96" "3" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "157.4" "145.4" "199.9" "484.9" "260.5" "161.9" "316.7" "180.4" "703.9" "2802.1" "3153.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z794" "Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3" "7" "4" "10" "1" "578" "61.9" "5.99" "1656.55" "16.86" "4" "4" "other biological processes" "plasma membrane;cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "374454" "ENSG00000189182" "KRT77" "hsa:374454; Q7RTS8; Q7Z794" "Formation of the cornified envelope" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "n/a" "n/a" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "3" "5" "10" "5" "3256" "358.5" "9.45" "1756.62" "16.85" "5" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "" "Primary focal segmental glomerulosclerosis (FSGS)" "1" "0" "250.4" "188.0" "234.6" "467.0" "287.6" "208.5" "389.9" "214.5" "271.5" "691.9" "494.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "35" "6" "10" "6" "172" "19.2" "5.40" "2037.23" "16.84" "5" "4" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "840.5" "615.7" "851.4" "1888.2" "1051.2" "652.9" "1802.6" "681.2" "852.3" "2967.8" "1582.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "20" "3" "7" "3" "310" "34.6" "6.52" "1274.49" "16.78" "2" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf13012" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "100.5" "94.3" "135.5" "475.3" "207.2" "134.8" "215.2" "113.4" "153.1" "415.1" "307.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "9" "5" "10" "5" "739" "83.3" "6.70" "1625.02" "16.75" "5" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "" "2" "0" "119.3" "115.0" "165.9" "624.1" "252.6" "121.8" "220.7" "119.5" "161.5" "438.8" "334.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92616" "eIF-2-alpha kinase activator GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=6" "4" "9" "13" "9" "2671" "292.6" "7.47" "2807.32" "16.65" "8" "5" "" "" "" "" "" "" "" "" "" "" "0" "0" "186.0" "189.4" "250.9" "735.8" "364.4" "223.4" "336.1" "230.7" "292.7" "792.4" "819.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92796" "Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2" "6" "3" "6" "3" "817" "90.3" "7.03" "1402.51" "16.64" "3" "3" "cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600" "1741" "ENSG00000082458" "DLG3" "B4E0H1; D3DVU5; hsa:1741; Q5JUW6; Q5JUW7; Q92796; Q9ULI8" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "" "10" "0" "66.2" "57.9" "76.8" "171.4" "106.1" "85.9" "115.1" "113.6" "212.2" "633.9" "776.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "15" "5" "8" "5" "396" "45.4" "8.91" "1180.36" "16.62" "4" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "" "2" "0" "152.1" "127.2" "185.8" "421.1" "241.2" "174.1" "312.5" "150.4" "271.7" "1158.7" "1103.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "17" "4" "9" "4" "317" "36.9" "4.40" "1377.45" "16.61" "3" "4" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "146.4" "119.6" "186.6" "646.6" "235.8" "98.2" "338.9" "144.9" "187.2" "596.2" "352.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "5" "4" "6" "4" "1075" "113.3" "8.59" "863.63" "16.60" "2" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "" "16p11.2 distal deletion syndrome" "1" "0" "624.2" "501.9" "723.3" "1197.7" "836.4" "570.7" "913.1" "434.6" "684.7" "939.2" "594.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BYD6" "39S ribosomal protein L1, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" "18" "4" "7" "4" "325" "36.9" "8.78" "1235.90" "16.55" "3" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00687" "65008" "ENSG00000169288" "MRPL1" "A6NG03; hsa:65008; Q4W5B8; Q6IAG4; Q96BW3; Q9BYD6; Q9H793; Q9NRL5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "155.8" "116.6" "210.2" "508.1" "262.0" "166.0" "326.4" "108.7" "268.8" "1704.1" "1635.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "15" "6" "11" "6" "523" "56.5" "6.42" "2015.55" "16.55" "6" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "Separation of Sister Chromatids; RHO GTPases Activate Formins; HCMV Early Events; Neutrophil degranulation; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein" "15" "0" "330.2" "277.8" "355.8" "947.4" "464.5" "289.6" "551.5" "263.0" "332.5" "957.4" "732.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "9" "4" "7" "4" "631" "71.6" "4.65" "1222.54" "16.50" "3" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "12" "0" "183.7" "174.5" "215.2" "515.1" "279.6" "200.0" "390.8" "189.8" "255.8" "1001.4" "885.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "43" "3" "5" "3" "108" "12.6" "9.52" "716.81" "16.46" "2" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "263.8" "228.7" "371.8" "1051.7" "508.8" "243.1" "602.5" "353.3" "442.8" "934.8" "740.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "28" "6" "10" "6" "200" "23.0" "8.37" "1889.52" "16.31" "5" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "776.3" "605.4" "870.2" "2321.8" "1203.5" "580.1" "842.0" "537.5" "749.6" "1271.3" "1475.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IWZ6" "Bardet-Biedl syndrome 7 protein OS=Homo sapiens OX=9606 GN=BBS7 PE=1 SV=2" "7" "4" "10" "4" "715" "80.3" "6.05" "1907.25" "16.28" "4" "4" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "55212" "ENSG00000138686" "BBS7" "hsa:55212; Q4W5P8; Q8IWZ6; Q8N581; Q9NVI4" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "79.7" "73.7" "98.5" "226.5" "124.2" "89.6" "177.9" "179.8" "408.4" "1539.2" "1198.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "42" "3" "8" "3" "81" "9.1" "8.43" "1684.11" "16.23" "3" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; UCH proteinases; Iron uptake and transport; TGF-beta receptor signaling activates SMADs" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "7" "0" "316.9" "325.3" "487.7" "2188.1" "731.9" "199.4" "383.4" "384.8" "292.2" "610.7" "541.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "5" "4" "7" "3" "1278" "141.6" "5.81" "1360.94" "16.22" "3" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Signaling by ALK fusions and activated point mutants; XBP1(S) activates chaperone genes" "" "6" "0" "25.9" "40.4" "52.1" "361.5" "75.3" "18.7" "65.6" "42.4" "39.9" "186.1" "109.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N8S7" "Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2" "11" "4" "8" "4" "591" "66.5" "6.93" "1650.23" "16.15" "3" "3" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "55740" "ENSG00000154380" "ENAH" "D0PQI2; hsa:55740; Q502W5; Q5T5M7; Q5VTQ9; Q5VTR0; Q8N8S7; Q9NVF3; Q9UFB8" "Generation of second messenger molecules; Signaling by ROBO receptors" "Regulation of actin cytoskeleton" "3" "0" "314.9" "223.9" "421.8" "1672.0" "563.1" "297.9" "614.4" "237.6" "359.4" "916.9" "472.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "7" "6" "11" "4" "898" "105.3" "7.30" "2105.99" "16.12" "6" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "MAPK signaling pathway" "4" "2" "145.4" "130.9" "158.3" "402.7" "213.6" "163.0" "294.8" "207.3" "452.6" "2195.8" "2027.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50454" "Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2" "14" "4" "7" "4" "418" "46.4" "8.69" "1009.33" "16.11" "3" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "871" "ENSG00000149257" "SERPINH1" "B3KVJ3; hsa:871; P29043; P50454; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88" "Collagen biosynthesis and modifying enzymes" "Endochondral ossification; Type I collagen synthesis in the context of osteogenesis imperfecta; Endochondral ossification with skeletal dysplasias; 15q13.3 copy number variation syndrome" "5" "0" "171.0" "170.4" "221.4" "717.6" "326.2" "166.4" "276.0" "203.7" "220.2" "524.8" "526.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01968" "Inositol polyphosphate 5-phosphatase OCRL OS=Homo sapiens OX=9606 GN=OCRL PE=1 SV=3" "6" "4" "11" "4" "901" "104.1" "6.55" "2483.38" "16.11" "4" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03372, Pf16726" "4952" "ENSG00000122126" "OCRL" "A6NKI1; A8KAP2; B7ZLX2; hsa:4952; O60800; Q01968; Q15684; Q15774; Q4VY09; Q4VY10; Q5JQF1; Q5JQF2; Q9UJG5; Q9UMA5" "Clathrin-mediated endocytosis; Synthesis of IP3 and IP4 in the cytosol; RAC3 GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of IP2, IP, and Ins in the cytosol" "VEGFA-VEGFR2 signaling; Ciliopathies; Bardet-Biedl syndrome" "11" "0" "96.3" "83.8" "120.5" "301.1" "182.9" "111.3" "180.3" "98.9" "175.1" "747.5" "766.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "42" "5" "11" "5" "106" "12.2" "9.35" "1623.05" "16.10" "4" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "" "Electron transport chain: OXPHOS system in mitochondria" "1" "0" "762.6" "686.8" "972.3" "2481.7" "1322.6" "707.3" "1062.7" "849.5" "1296.0" "1938.5" "2642.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2 PE=1 SV=1" "70" "5" "9" "5" "86" "10.1" "6.52" "1955.20" "16.09" "5" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "0" "257.2" "239.9" "421.3" "2163.5" "646.7" "163.9" "591.5" "299.2" "331.2" "939.7" "607.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "20" "4" "8" "4" "293" "32.8" "7.50" "1670.98" "16.03" "4" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "179.4" "169.5" "270.3" "1022.8" "437.1" "180.4" "369.4" "239.4" "265.6" "837.0" "642.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "16" "4" "8" "4" "315" "37.1" "4.64" "1479.86" "16.01" "4" "4" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13833" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "5" "0" "387.2" "235.7" "415.5" "728.8" "457.0" "289.2" "627.8" "243.7" "366.9" "736.4" "462.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "13" "5" "9" "4" "411" "46.8" "6.73" "2343.93" "16.01" "5" "4" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "8" "0" "431.3" "423.6" "519.7" "1493.0" "744.7" "319.3" "688.2" "433.6" "378.5" "1136.8" "964.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "11" "3" "10" "3" "372" "40.9" "8.35" "1848.61" "15.93" "3" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "6" "0" "125.8" "140.9" "202.3" "460.4" "226.5" "162.4" "282.2" "201.1" "268.9" "1257.2" "1823.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "5" "4" "8" "4" "1272" "141.3" "5.41" "1632.04" "15.91" "4" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "RHOA GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "14" "0" "146.2" "114.7" "152.7" "294.9" "184.0" "130.4" "237.2" "114.5" "147.0" "401.3" "317.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "12" "1" "7" "1" "153" "17.2" "8.22" "1956.47" "15.85" "1" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "140.3" "107.8" "151.2" "280.5" "165.1" "112.0" "258.5" "119.4" "284.9" "1351.2" "1058.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36959" "GMP reductase 1 OS=Homo sapiens OX=9606 GN=GMPR PE=1 SV=1" "9" "2" "4" "1" "345" "37.4" "7.06" "" "15.81" "" "2" "other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00478" "2766" "ENSG00000137198" "GMPR" "hsa:2766; P36959; Q96HQ6" "Purine salvage" "" "1" "0" "5.6" "4.0" "7.0" "22.1" "11.5" "10.1" "14.8" "22.0" "61.4" "431.9" "517.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "5" "3" "5" "3" "1299" "150.0" "5.54" "655.51" "15.70" "1" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "" "VEGFA-VEGFR2 signaling" "1" "0" "79.1" "72.5" "93.0" "219.4" "124.0" "70.8" "132.3" "92.0" "85.2" "212.4" "173.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "12" "5" "9" "5" "433" "48.3" "7.47" "1921.20" "15.68" "5" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Phosphorylation of Emi1" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; DNA damage response" "31" "0" "474.5" "346.8" "496.0" "812.0" "546.0" "417.3" "767.9" "319.6" "555.0" "1367.9" "1149.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "10" "6" "10" "6" "592" "67.5" "4.60" "2392.56" "15.63" "6" "4" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "Maturation of spike protein; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Calnexin/calreticulin cycle; Maturation of spike protein" "" "8" "0" "471.9" "444.7" "783.6" "4190.5" "1438.5" "417.0" "748.9" "629.3" "644.6" "1196.3" "1202.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "1" "2" "10" "2" "2078" "205.3" "9.58" "1761.49" "15.63" "2" "2" "transport" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "29.2" "17.5" "34.5" "56.1" "40.2" "22.9" "29.3" "21.1" "21.7" "44.3" "35.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "13" "4" "8" "2" "420" "46.4" "9.57" "1696.39" "15.50" "4" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "0" "136.2" "137.0" "168.5" "474.3" "243.0" "152.9" "258.7" "134.1" "140.7" "301.4" "186.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "12" "3" "6" "3" "256" "27.7" "7.78" "631.12" "15.44" "2" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Detoxification of Reactive Oxygen Species" "Selenium micronutrient network" "2" "0" "96.7" "104.1" "119.3" "1986.2" "224.5" "19.9" "136.6" "346.7" "123.4" "622.2" "621.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "32" "8" "14" "1" "213" "21.4" "10.93" "3593.86" "15.43" "8" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "169.2" "144.1" "198.3" "377.9" "248.7" "211.2" "338.4" "108.8" "181.9" "305.6" "135.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "12" "5" "9" "4" "501" "58.8" "5.38" "1895.34" "15.43" "5" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "mRNA Splicing - Major Pathway" "Exercise-induced circadian regulation; mRNA processing" "3" "1" "309.8" "252.0" "375.9" "1005.4" "516.7" "335.8" "607.8" "280.1" "354.0" "971.2" "663.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "5" "6" "10" "6" "1394" "157.8" "6.13" "2328.56" "15.37" "6" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Ciliary landscape" "4" "0" "299.4" "304.1" "570.7" "2704.7" "881.9" "388.2" "656.2" "378.6" "447.4" "1482.1" "1246.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "18" "6" "9" "5" "418" "47.3" "5.21" "1515.06" "15.37" "5" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Neddylation; KEAP1-NFE2L2 pathway; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "64" "1" "249.5" "229.1" "324.4" "1205.1" "477.4" "287.0" "454.3" "319.7" "290.5" "865.2" "752.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "8" "5" "9" "5" "709" "81.0" "6.87" "1863.14" "15.33" "5" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "" "12" "0" "570.4" "457.4" "643.9" "1982.9" "907.5" "466.3" "826.7" "669.4" "585.6" "1255.2" "1135.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "45" "5" "10" "5" "121" "13.4" "7.24" "1720.01" "15.31" "5" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "MASTL Facilitates Mitotic Progression" "" "1" "0" "378.1" "357.9" "429.1" "1384.6" "603.9" "291.7" "421.5" "308.6" "432.5" "1325.4" "1415.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "16" "5" "8" "4" "406" "45.6" "7.55" "1335.73" "15.30" "4" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Regulation of expression of SLITs and ROBOs; AUF1 (hnRNP D0) binds and destabilizes mRNA; Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-1 signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "65" "0" "61.7" "54.3" "83.6" "255.2" "133.7" "55.1" "118.6" "72.9" "72.5" "275.7" "243.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "17" "5" "8" "3" "284" "33.3" "9.31" "1596.32" "15.29" "4" "4" "other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "2" "256.7" "254.0" "340.4" "750.2" "379.4" "243.9" "472.7" "224.8" "289.5" "952.2" "798.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "14" "2" "6" "2" "258" "27.3" "6.40" "1984.51" "15.08" "2" "2" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "93.4" "104.3" "153.8" "788.0" "272.5" "89.6" "90.1" "92.2" "131.7" "330.5" "463.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "15" "5" "9" "4" "334" "36.6" "6.05" "1659.16" "15.05" "5" "4" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Pyruvate metabolism" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis" "4" "0" "285.8" "285.8" "462.3" "2867.8" "953.9" "148.8" "246.3" "290.5" "227.4" "476.3" "518.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "11" "4" "8" "3" "482" "54.1" "5.55" "1301.14" "15.01" "3" "3" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "150.0" "135.6" "194.5" "584.0" "257.5" "133.5" "307.6" "191.5" "249.3" "1034.5" "1160.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H9B4" "Sideroflexin-1 OS=Homo sapiens OX=9606 GN=SFXN1 PE=1 SV=4" "17" "4" "7" "4" "322" "35.6" "9.07" "891.84" "15.01" "3" "4" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf03820" "94081" "ENSG00000164466" "SFXN1" "B3KPW3; D3DQN2; hsa:94081; Q9H9B4; Q9HA53" "" "" "0" "0" "91.7" "72.7" "118.8" "409.8" "170.9" "90.9" "142.8" "104.5" "115.0" "387.1" "502.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "5" "4" "8" "4" "1023" "112.8" "5.49" "1407.58" "15.01" "4" "4" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "6" "0" "198.8" "210.2" "272.5" "1133.1" "428.6" "198.0" "386.0" "229.1" "278.4" "1101.0" "997.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43795" "Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3" "5" "4" "8" "3" "1136" "131.9" "9.38" "1168.70" "14.94" "3" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4430" "ENSG00000128641" "MYO1B" "hsa:4430; O43794; O43795; Q7Z6L5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95785" "Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2" "2" "3" "6" "3" "1651" "178.6" "6.86" "1535.44" "14.93" "3" "3" "RNA metabolism OR transcription;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "58525" "ENSG00000011451" "WIZ" "B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1" "" "" "0" "0" "45.1" "37.2" "57.2" "107.7" "68.0" "48.6" "84.6" "32.2" "57.9" "122.6" "82.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46821" "Microtubule-associated protein 1B OS=Homo sapiens OX=9606 GN=MAP1B PE=1 SV=2" "2" "4" "8" "4" "2468" "270.5" "4.81" "1718.86" "14.85" "4" "4" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00414" "4131" "ENSG00000131711" "MAP1B" "A2BDK5; hsa:4131; P46821" "" "Microtubule cytoskeleton regulation; Fragile X syndrome; Neurogenesis regulation in the olfactory epithelium" "3" "0" "295.3" "242.2" "310.7" "644.7" "376.5" "248.5" "400.3" "203.7" "275.9" "623.2" "480.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "9" "5" "9" "5" "589" "65.3" "5.11" "2134.25" "14.84" "5" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Negative regulation of MAPK pathway; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "49" "0" "206.1" "176.5" "339.7" "990.5" "453.0" "193.8" "555.4" "280.6" "321.4" "808.8" "617.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "9" "3" "8" "2" "392" "46.5" "10.01" "1412.23" "14.84" "3" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "1" "161.8" "145.7" "224.8" "679.2" "315.5" "187.3" "321.0" "204.9" "190.8" "541.2" "506.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "6" "5" "12" "5" "803" "92.4" "4.84" "2051.16" "14.82" "5" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf02518" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Trafficking and processing of endosomal TLR; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "446.6" "485.5" "726.3" "3451.1" "1207.7" "358.2" "635.0" "536.9" "466.8" "1140.3" "1007.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "4" "4" "7" "4" "1150" "132.7" "5.76" "1039.70" "14.74" "3" "4" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "mRNA Splicing - Major Pathway" "" "1" "0" "362.3" "324.1" "427.9" "702.3" "444.5" "418.3" "495.7" "281.9" "385.9" "733.8" "557.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRT2" "Ubiquinol-cytochrome-c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1" "18" "3" "7" "3" "126" "14.9" "7.37" "1674.49" "14.72" "3" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf20180" "84300" "ENSG00000137288" "UQCC2" "B2R4I0; hsa:84300; Q9BRT2" "" "Mitochondrial complex III assembly" "1" "0" "120.9" "135.7" "258.5" "544.6" "289.2" "146.7" "361.6" "164.6" "363.4" "1547.0" "1683.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "9" "4" "7" "4" "808" "87.1" "9.19" "1022.16" "14.68" "3" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "TBC/RABGAPs" "" "1" "0" "36.3" "31.9" "49.5" "99.5" "67.9" "43.9" "71.9" "34.4" "60.7" "313.2" "317.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "20" "7" "13" "6" "332" "36.7" "8.27" "2289.19" "14.67" "7" "5" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Pyruvate metabolism" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; A network map of Macrophage-stimulating protein (MSP) signaling" "17" "1" "530.1" "533.8" "872.0" "4154.6" "1445.6" "329.9" "664.6" "619.0" "533.2" "1346.6" "1405.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "8" "2" "4" "2" "471" "53.1" "6.23" "582.03" "14.67" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "3" "0" "39.3" "41.3" "51.6" "185.1" "72.3" "42.1" "59.7" "49.6" "57.6" "207.7" "573.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "20" "4" "7" "4" "324" "37.0" "6.77" "1131.63" "14.62" "3" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Ub-specific processing proteases; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "114.6" "96.1" "156.6" "474.3" "218.1" "153.7" "241.9" "185.3" "200.7" "513.5" "465.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "14" "6" "10" "6" "514" "55.8" "6.90" "3036.03" "14.62" "6" "4" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Potential therapeutics for SARS; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "Rett syndrome causing genes" "5" "0" "260.4" "223.3" "355.9" "1586.0" "569.6" "191.7" "381.0" "352.7" "307.7" "917.8" "824.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4G6" "Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4" "2" "6" "12" "1" "2542" "271.4" "5.57" "1906.31" "14.56" "6" "4" "cell adhesion;cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511" "83660" "ENSG00000171914" "TLN2" "A6NLB8; hsa:83660; Q9Y4G6" "" "Focal adhesion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96T37" "RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2" "6" "4" "9" "4" "977" "107.1" "10.08" "1835.16" "14.49" "4" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf07744" "64783" "ENSG00000162775" "RBM15" "A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0" "" "" "0" "0" "62.0" "56.6" "84.1" "205.8" "125.8" "80.2" "167.0" "154.7" "337.2" "911.9" "806.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "5" "5" "10" "5" "1101" "128.7" "8.38" "1446.33" "14.48" "5" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "276.9" "212.2" "296.3" "589.3" "350.3" "289.0" "522.8" "230.2" "371.7" "1235.4" "950.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "22" "4" "7" "4" "184" "20.7" "7.99" "1171.51" "14.48" "3" "4" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "106.3" "92.6" "145.5" "420.8" "209.2" "100.8" "214.3" "122.2" "168.3" "374.2" "372.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "5" "4" "9" "4" "1071" "123.3" "6.06" "1376.45" "14.39" "3" "4" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "18" "0" "26.3" "27.8" "40.7" "154.7" "49.2" "23.7" "52.4" "28.2" "49.4" "137.3" "118.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3E5" "Peptidyl-tRNA hydrolase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PTRH2 PE=1 SV=1" "21" "2" "5" "2" "179" "19.2" "8.73" "832.49" "14.39" "1" "2" "other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01981" "51651" "ENSG00000141378" "PTRH2" "B3KUY4; hsa:51651; Q9NTE5; Q9Y3E5" "Ub-specific processing proteases" "Apoptosis modulation and signaling" "2" "0" "91.5" "83.8" "121.4" "327.3" "165.3" "101.0" "184.9" "91.0" "153.2" "892.9" "779.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VUJ6" "Leucine-rich repeat and calponin homology domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LRCH2 PE=1 SV=2" "8" "4" "6" "4" "765" "84.5" "6.55" "1251.89" "14.38" "3" "3" "" "" "" "Pf00307, Pf13855" "57631" "ENSG00000130224" "LRCH2" "F5H2T1; hsa:57631; Q08AD5; Q5VUJ6; Q9HA88; Q9P233" "" "" "0" "0" "60.0" "65.3" "86.1" "230.9" "120.2" "71.3" "145.8" "84.5" "156.7" "616.5" "656.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "46" "4" "7" "1" "113" "12.7" "7.44" "1234.78" "14.38" "3" "4" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "2" "0" "0.0" "2.5" "3.9" "16.5" "4.0" "1.2" "3.4" "12.9" "3.8" "209.8" "570.2" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96GQ7" "Probable ATP-dependent RNA helicase DDX27 OS=Homo sapiens OX=9606 GN=DDX27 PE=1 SV=2" "8" "5" "10" "5" "796" "89.8" "9.28" "1752.32" "14.36" "5" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "55661" "" "DDX27" "A0AVB6; B7ZLY1; hsa:55661; Q5VXM7; Q8WYG4; Q969N7; Q96F57; Q96GQ7; Q96L97; Q9BWY9; Q9BXF0; Q9H990; Q9NWU3; Q9P0C2; Q9UGD6" "" "" "0" "0" "63.7" "56.9" "74.0" "182.4" "100.0" "53.8" "121.7" "60.9" "76.0" "211.4" "160.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "6" "6" "10" "6" "1058" "117.8" "5.76" "2368.32" "14.33" "6" "4" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "5" "0" "433.7" "514.3" "842.5" "5589.3" "1583.8" "404.7" "600.9" "672.9" "513.4" "1229.9" "1252.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "16" "3" "5" "3" "309" "35.6" "5.54" "748.21" "14.31" "2" "3" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; CTLA4 inhibitory signaling; Separation of Sister Chromatids; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "52" "0" "149.7" "144.0" "216.6" "499.0" "225.6" "144.7" "318.6" "188.6" "208.4" "609.4" "435.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96P47" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=AGAP3 PE=1 SV=2" "6" "4" "6" "4" "875" "95.0" "7.97" "671.70" "14.27" "2" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071, Pf01412, Pf12796" "116988" "ENSG00000133612" "AGAP3" "B3KNZ8; E9PAL8; hsa:116988; Q59EN0; Q96P47; Q96RK3" "" "" "0" "0" "79.4" "71.9" "97.4" "234.4" "147.7" "99.5" "154.9" "119.8" "298.9" "1050.3" "1086.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "9" "3" "7" "1" "375" "41.6" "7.74" "1335.12" "14.26" "3" "3" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "FGFR2 alternative splicing" "" "1" "0" "134.6" "111.6" "178.3" "336.8" "204.5" "144.5" "296.3" "125.2" "177.9" "297.8" "164.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "14" "3" "5" "3" "413" "46.2" "7.01" "972.41" "14.25" "2" "3" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis" "10" "0" "7.3" "11.3" "14.8" "81.5" "21.8" "3.1" "9.9" "7.6" "7.3" "23.4" "23.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "7" "3" "5" "3" "594" "66.0" "9.19" "1107.38" "14.24" "2" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "128.7" "85.3" "130.7" "327.0" "191.2" "135.2" "213.4" "111.5" "206.4" "918.0" "778.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "26" "4" "7" "4" "244" "27.3" "5.15" "1291.71" "14.23" "3" "4" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "Post-chaperonin tubulin folding pathway" "" "1" "0" "151.4" "140.0" "190.1" "896.4" "335.7" "100.9" "172.7" "149.1" "139.3" "244.1" "319.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "19" "8" "12" "1" "364" "39.4" "6.87" "2237.75" "14.20" "7" "5" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "18" "5" "9" "5" "290" "31.4" "8.07" "1880.62" "14.12" "5" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "10" "0" "369.6" "388.6" "588.7" "2878.0" "948.6" "267.2" "565.6" "422.5" "463.9" "1064.8" "943.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "8" "5" "9" "5" "826" "92.2" "7.90" "1227.77" "14.09" "4" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "" "4" "0" "42.2" "34.9" "55.1" "282.6" "91.6" "36.1" "68.5" "54.4" "65.1" "778.5" "1559.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "22" "5" "8" "5" "241" "26.9" "5.17" "1478.72" "14.05" "4" "4" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "" "VEGFA-VEGFR2 signaling" "1" "0" "116.1" "115.4" "178.3" "1355.6" "374.9" "47.3" "149.4" "158.4" "127.9" "334.3" "304.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZ29" "Dedicator of cytokinesis protein 9 OS=Homo sapiens OX=9606 GN=DOCK9 PE=1 SV=2" "3" "4" "8" "3" "2069" "236.3" "7.49" "1496.30" "14.03" "4" "4" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "23348" "ENSG00000088387" "DOCK9" "B3KX25; E9PFM9; hsa:23348; Q5JUD4; Q5JUD6; Q5T2Q1; Q5TAN8; Q9BZ25; Q9BZ26; Q9BZ27; Q9BZ28; Q9BZ29; Q9UPU4" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle" "" "3" "0" "49.1" "40.4" "62.1" "113.6" "87.0" "104.2" "321.3" "253.0" "349.7" "438.8" "222.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L804" "Rab11 family-interacting protein 2 OS=Homo sapiens OX=9606 GN=RAB11FIP2 PE=1 SV=1" "15" "6" "9" "4" "512" "58.2" "9.32" "1997.11" "14.00" "5" "4" "cell-cell signaling;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf09457" "22841" "ENSG00000107560" "RAB11FIP2" "A6NEI4; hsa:22841; Q3I768; Q7L804; Q9Y2F0" "Vasopressin regulates renal water homeostasis via Aquaporins" "" "1" "0" "68.2" "57.0" "78.6" "200.6" "94.3" "70.1" "150.2" "213.7" "479.1" "1058.2" "758.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "17" "4" "8" "4" "308" "34.5" "5.12" "1638.87" "13.92" "4" "4" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "179.3" "156.6" "230.7" "635.1" "333.6" "190.9" "413.1" "207.7" "255.3" "794.4" "632.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "25" "6" "11" "6" "255" "28.4" "8.62" "1947.12" "13.90" "6" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "mRNA processing" "3" "0" "319.9" "294.3" "371.6" "943.4" "520.7" "289.9" "564.7" "319.8" "385.7" "1020.7" "919.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "28" "3" "10" "3" "92" "10.8" "9.44" "1841.28" "13.86" "3" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "167.6" "167.4" "217.0" "673.6" "301.4" "168.7" "384.2" "214.5" "239.2" "774.6" "600.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "28" "4" "6" "3" "172" "19.5" "6.34" "774.41" "13.85" "2" "4" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "47.9" "43.8" "66.7" "158.0" "154.1" "259.2" "682.5" "409.1" "1023.4" "1293.4" "810.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96HC4" "PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5" "5" "2" "6" "2" "596" "63.9" "8.21" "1654.33" "13.82" "2" "2" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "10611" "ENSG00000163110" "PDLIM5" "A8K6F9; D6RB78; E9PBF5; hsa:10611; O60705; Q56VN4; Q5UW38; Q8WVK0; Q96HC4" "Neurexins and neuroligins" "Extracellular vesicles in the crosstalk of cardiac cells" "2" "0" "306.9" "236.3" "288.2" "562.6" "326.0" "265.0" "374.9" "205.0" "299.5" "627.5" "580.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P0K7" "Ankycorbin OS=Homo sapiens OX=9606 GN=RAI14 PE=1 SV=2" "3" "3" "7" "2" "980" "110.0" "6.21" "1783.43" "13.81" "3" "2" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00023, Pf12796" "26064" "ENSG00000039560" "RAI14" "E9PED3; hsa:26064; Q6V1W9; Q7Z5I4; Q7Z733; Q9P0K7; Q9P2L2; Q9Y3T5" "" "" "0" "0" "59.5" "66.1" "90.8" "206.6" "105.4" "59.9" "139.4" "84.3" "130.4" "858.6" "945.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2D4" "Exocyst complex component 6B OS=Homo sapiens OX=9606 GN=EXOC6B PE=1 SV=3" "5" "3" "7" "3" "811" "94.1" "6.46" "1172.57" "13.81" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "other cell component" "" "Pf04091" "23233" "ENSG00000144036" "EXOC6B" "B8ZZY3; hsa:23233; Q9Y2D4" "" "Ciliary landscape" "1" "0" "49.9" "41.7" "75.0" "158.5" "85.1" "58.3" "109.7" "82.5" "151.8" "765.1" "569.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "5" "5" "8" "5" "1094" "121.2" "6.04" "1489.70" "13.79" "4" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "" "2" "0" "184.3" "165.2" "204.1" "575.9" "269.2" "187.2" "368.8" "176.4" "231.2" "1124.3" "1018.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "18" "4" "9" "4" "263" "28.5" "6.92" "1811.73" "13.76" "4" "3" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "374.0" "361.1" "472.7" "1144.1" "631.3" "367.8" "643.3" "341.7" "432.3" "1192.4" "1004.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "17" "4" "7" "4" "333" "35.1" "8.38" "1210.88" "13.75" "3" "4" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "Respiratory electron transport" "" "1" "0" "47.4" "26.8" "71.7" "222.2" "82.4" "46.4" "70.6" "57.8" "52.3" "191.8" "172.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "11" "5" "9" "5" "611" "69.1" "5.73" "1927.58" "13.74" "5" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; mTORC1-mediated signalling" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "14" "0" "246.0" "200.4" "289.9" "1023.1" "431.9" "187.6" "304.5" "150.0" "174.4" "303.3" "174.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "5" "3" "8" "3" "847" "94.6" "6.25" "1511.33" "13.74" "3" "3" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "39.3" "38.0" "66.5" "249.4" "96.9" "36.9" "98.2" "47.7" "52.8" "202.1" "137.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07711" "Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2" "13" "3" "5" "3" "333" "37.5" "5.45" "643.08" "13.74" "2" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1514" "ENSG00000135047" "CTSL" "hsa:1514; P07711; Q6IAV1; Q96QJ0" "MHC class II antigen presentation; Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Attachment and Entry; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Attachment and Entry; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "Primary focal segmental glomerulosclerosis (FSGS); Ebola virus infection in host; Mitochondrial immune response to SARS-CoV-2" "12" "0" "48.8" "45.5" "62.3" "200.0" "92.0" "60.5" "81.2" "95.9" "417.5" "1717.4" "2244.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "11" "4" "6" "4" "577" "60.9" "6.83" "654.87" "13.67" "2" "4" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "199.1" "162.4" "298.7" "785.7" "382.7" "176.3" "447.1" "227.8" "361.1" "1258.6" "960.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "13" "2" "4" "2" "277" "31.3" "5.15" "426.13" "13.65" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.0" "3.1" "7.3" "17.1" "7.2" "5.4" "15.3" "14.3" "22.9" "189.7" "124.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13523" "Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRPF4B PE=1 SV=3" "3" "3" "8" "3" "1007" "116.9" "10.26" "1695.16" "13.61" "3" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8899" "ENSG00000112739" "PRPF4B" "A8K5C9; hsa:8899; Q13523; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "35.0" "35.3" "43.7" "150.6" "76.2" "40.5" "78.1" "40.3" "51.3" "313.1" "279.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P1N0" "Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1" "4" "3" "7" "3" "951" "104.0" "8.09" "1378.30" "13.48" "3" "3" "RNA metabolism OR transcription;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00168" "54862" "ENSG00000132024; ENSG00000288293" "CC2D1A" "hsa:54862; Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "0" "149.5" "154.3" "189.1" "452.8" "248.1" "174.3" "292.0" "174.1" "199.4" "543.5" "401.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UGP8" "Translocation protein SEC63 homolog OS=Homo sapiens OX=9606 GN=SEC63 PE=1 SV=2" "8" "6" "9" "6" "760" "87.9" "5.31" "1852.83" "13.48" "5" "4" "other metabolic processes;transport;developmental processes" "other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00226, Pf02889" "11231" "ENSG00000025796" "SEC63" "hsa:11231; O95380; Q5THN4; Q86VS9; Q8IWL0; Q9NTE0; Q9UGP8" "" "" "0" "0" "412.2" "423.0" "575.4" "1969.1" "790.4" "453.7" "752.1" "461.8" "568.7" "1506.8" "1372.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF-2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "5" "2" "6" "2" "523" "57.5" "9.38" "1486.56" "13.46" "2" "2" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Recycling of eIF2:GDP" "Translation factors; Primary ovarian insufficiency" "3" "0" "67.0" "74.9" "91.0" "225.0" "122.1" "74.6" "148.7" "91.3" "105.2" "290.7" "300.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "12" "4" "7" "4" "508" "57.1" "4.87" "999.44" "13.45" "3" "4" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "Hedgehog ligand biogenesis; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling; Chylomicron assembly; VLDL assembly; LDL remodeling" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "13" "0" "219.3" "234.9" "294.9" "1462.8" "458.8" "165.2" "356.9" "268.2" "242.2" "756.6" "581.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "12" "5" "6" "5" "313" "35.1" "7.69" "515.59" "13.36" "2" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "555.2" "425.8" "564.3" "1043.0" "629.6" "457.2" "767.8" "411.5" "525.6" "1167.0" "991.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "6" "3" "7" "3" "708" "80.5" "5.90" "1947.62" "13.35" "3" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "32" "0" "56.1" "47.9" "66.3" "205.6" "92.8" "53.9" "118.6" "71.8" "94.8" "223.1" "188.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "18" "4" "8" "3" "200" "22.5" "8.38" "1615.10" "13.35" "4" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Neutrophil degranulation; RAB geranylgeranylation" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "5" "1" "166.9" "150.4" "195.5" "801.5" "324.8" "133.1" "196.6" "188.2" "159.9" "317.8" "316.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NW13" "RNA-binding protein 28 OS=Homo sapiens OX=9606 GN=RBM28 PE=1 SV=3" "6" "4" "7" "4" "759" "85.7" "9.22" "1093.63" "13.34" "3" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "55131" "ENSG00000106344" "RBM28" "A4D100; B4DU52; E9PDD9; hsa:55131; Q53H65; Q96CV3; Q9NW13" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "207.4" "180.6" "282.4" "865.0" "394.5" "197.5" "367.4" "184.7" "299.0" "538.3" "382.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "25" "4" "5" "4" "248" "27.7" "10.36" "645.80" "13.33" "2" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "247.9" "280.3" "344.8" "1042.3" "474.8" "249.1" "545.8" "323.3" "280.4" "617.5" "465.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2R9" "28S ribosomal protein S7, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "19" "4" "7" "4" "242" "28.1" "9.99" "1036.47" "13.32" "3" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "131.6" "129.1" "165.9" "500.1" "245.5" "173.8" "284.2" "198.7" "249.8" "692.3" "543.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "20" "4" "9" "4" "142" "17.0" "6.18" "1120.29" "13.31" "4" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Potential therapeutics for SARS; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "18" "0" "112.5" "114.9" "163.7" "364.6" "207.8" "169.6" "496.2" "663.4" "1166.3" "2006.2" "1542.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q04695" "Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2" "12" "7" "13" "1" "432" "48.1" "5.02" "2287.25" "13.18" "7" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton" "other molecular function" "Pf00038" "3872" "ENSG00000128422" "KRT17" "A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2; hsa:3872; Q04695; Q6IP98; Q8N1P6" "Formation of the cornified envelope" "1p36 copy number variation syndrome; Pancreatic cancer subtypes" "4" "0" "447.0" "206.5" "141.7" "124.3" "88.4" "64.8" "97.0" "53.6" "51.1" "168.0" "191.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "10" "4" "8" "4" "514" "57.2" "9.17" "1496.34" "13.16" "4" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "mRNA Splicing - Major Pathway" "" "1" "0" "195.3" "193.3" "253.4" "762.1" "342.3" "202.0" "458.9" "181.1" "276.3" "1579.5" "1391.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P16402" "Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2" "30" "8" "13" "1" "221" "22.3" "11.02" "3382.04" "13.15" "8" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3007" "ENSG00000124575" "H1-3" "B2R751; hsa:3007; P16402; Q2M2I2" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation" "" "2" "0" "15.9" "9.0" "18.0" "27.8" "13.7" "11.7" "20.2" "7.1" "12.5" "19.9" "12.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60739" "Eukaryotic translation initiation factor 1b OS=Homo sapiens OX=9606 GN=EIF1B PE=1 SV=2" "46" "4" "7" "1" "113" "12.8" "7.37" "1179.59" "13.12" "3" "4" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus" "translation activity;nucleic acid binding activity" "Pf01253" "10289" "ENSG00000114784" "EIF1B" "hsa:10289; O60739; Q9UQF8" "" "" "0" "2" "64.8" "55.9" "80.3" "253.6" "116.1" "70.0" "130.5" "92.0" "150.3" "745.5" "1212.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "26" "4" "9" "4" "178" "20.4" "5.03" "1630.68" "13.12" "4" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "" "Metapathway biotransformation Phase I and II" "1" "0" "95.2" "98.3" "123.7" "358.3" "191.5" "115.7" "190.5" "106.8" "172.3" "993.1" "1561.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22570" "NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3" "14" "5" "7" "5" "491" "53.8" "8.44" "973.43" "13.04" "3" "4" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "2232" "ENSG00000161513" "FDXR" "B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "Iron-sulfur cluster biogenesis" "5" "0" "98.2" "83.6" "139.9" "430.6" "203.9" "119.2" "221.1" "104.0" "223.4" "1043.3" "1372.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "36" "4" "7" "4" "163" "18.2" "8.82" "1215.19" "13.02" "3" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation; RHO GTPases Activate NADPH Oxidases" "Novel intracellular components of RIG-I-like receptor pathway" "6" "0" "191.6" "199.2" "265.9" "611.6" "319.1" "212.9" "518.5" "224.6" "255.4" "606.3" "384.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "13" "3" "7" "3" "239" "25.3" "4.92" "1035.72" "12.98" "2" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "298.5" "287.5" "331.0" "930.2" "455.0" "252.0" "476.9" "291.7" "326.8" "849.8" "741.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQG0" "Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2" "5" "4" "7" "4" "1328" "148.8" "9.28" "994.82" "12.96" "3" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04931" "10514" "ENSG00000132382" "MYBBP1A" "hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99" "B-WICH complex positively regulates rRNA expression" "Energy metabolism" "2" "0" "75.6" "84.1" "119.2" "291.1" "108.5" "75.4" "142.7" "104.4" "92.9" "284.3" "205.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95208" "Epsin-2 OS=Homo sapiens OX=9606 GN=EPN2 PE=1 SV=3" "6" "5" "9" "5" "641" "68.4" "7.52" "1515.74" "12.96" "5" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "22905" "ENSG00000072134" "EPN2" "A8MTV8; B3KRX8; E9PBC2; hsa:22905; O95207; O95208; Q52LD0; Q9H7Z2; Q9UPT7" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "103.3" "104.2" "144.5" "377.3" "310.7" "248.8" "571.6" "356.4" "418.0" "1058.5" "696.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12800" "Alpha-globin transcription factor CP2 OS=Homo sapiens OX=9606 GN=TFCP2 PE=1 SV=2" "10" "3" "6" "2" "502" "57.2" "5.80" "1195.33" "12.92" "3" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7024" "ENSG00000135457" "TFCP2" "A8K5E9; hsa:7024; Q12800; Q12801; Q9UD75; Q9UD77" "" "VEGFA-VEGFR2 signaling" "1" "1" "21.6" "22.9" "34.1" "77.4" "41.0" "23.0" "43.1" "23.1" "43.3" "238.3" "254.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NP97" "Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3" "42" "3" "8" "3" "96" "10.9" "7.25" "1462.84" "12.86" "3" "3" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83658" "ENSG00000125971" "DYNLRB1" "B1AKR5; hsa:83658; Q5TC72; Q96IV3; Q9NP97; Q9NQM2" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "4" "0" "141.3" "128.0" "162.8" "379.9" "217.9" "132.3" "232.5" "122.7" "165.9" "479.0" "363.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BVP2" "Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2" "12" "5" "7" "5" "549" "62.0" "9.16" "1411.14" "12.85" "4" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf08701" "26354" "ENSG00000163938" "GNL3" "B2RDC1; hsa:26354; Q5PU80; Q96SV6; Q96SV7; Q9BVP2; Q9UJY0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "385.1" "336.5" "402.3" "1032.2" "487.7" "300.6" "644.2" "319.6" "399.4" "1251.3" "917.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P5R6" "60S ribosomal protein L22-like 1 OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "39" "3" "5" "3" "122" "14.6" "9.38" "806.24" "12.81" "2" "3" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "134.0" "121.6" "164.4" "364.8" "200.4" "138.8" "242.6" "135.7" "170.6" "665.9" "660.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "17" "2" "9" "2" "59" "6.9" "10.45" "1814.43" "12.80" "2" "2" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "659.8" "473.7" "707.6" "850.6" "843.4" "637.3" "907.4" "443.5" "785.1" "1074.0" "760.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "11" "5" "11" "5" "431" "49.2" "5.58" "1932.13" "12.77" "5" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "4" "0" "339.5" "284.1" "410.2" "1010.3" "505.8" "292.7" "530.6" "325.4" "509.5" "1617.8" "1649.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A3KMH1" "von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2" "2" "4" "8" "4" "1905" "214.7" "7.40" "1419.84" "12.76" "4" "4" "" "mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07728" "23078" "ENSG00000102763" "VWA8" "A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4" "" "" "0" "0" "138.1" "157.5" "185.9" "382.1" "224.7" "167.2" "310.7" "186.8" "237.3" "595.6" "516.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55795" "Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1" "16" "6" "10" "1" "449" "49.2" "6.30" "1649.00" "12.74" "5" "4" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00076, Pf08080" "3188" "ENSG00000126945" "HNRNPH2" "A1L400; hsa:3188; P55795; Q9HHA7" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "19.0" "24.9" "23.9" "102.2" "42.5" "19.8" "36.4" "22.4" "28.5" "82.7" "78.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "6" "5" "9" "5" "763" "82.9" "9.04" "1582.69" "12.70" "5" "4" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "210.2" "206.4" "287.9" "1052.1" "436.3" "180.0" "403.0" "254.5" "293.7" "1028.8" "942.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q05823" "2-5A-dependent ribonuclease OS=Homo sapiens OX=9606 GN=RNASEL PE=1 SV=2" "6" "4" "8" "4" "741" "83.5" "6.65" "1270.21" "12.70" "4" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00023, Pf00069, Pf06479" "6041" "ENSG00000135828" "RNASEL" "hsa:6041; Q05823; Q5W0L2; Q6AI46" "OAS antiviral response; Interferon alpha/beta signaling" "" "2" "0" "29.6" "29.8" "33.8" "100.5" "55.0" "39.2" "75.1" "107.0" "288.1" "807.4" "783.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "9" "4" "7" "4" "637" "72.6" "6.29" "906.31" "12.68" "3" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "5" "0" "243.1" "243.5" "333.4" "1111.4" "468.0" "217.2" "440.3" "245.4" "253.5" "753.6" "587.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96BJ3" "Axin interactor, dorsalization-associated protein OS=Homo sapiens OX=9606 GN=AIDA PE=1 SV=1" "17" "3" "5" "3" "306" "35.0" "6.55" "790.55" "12.63" "2" "3" "developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf08910, Pf14186" "64853" "ENSG00000186063" "AIDA" "A8K1F0; hsa:64853; Q49A81; Q5JRA4; Q658P1; Q96BJ3; Q9H9E8" "" "" "0" "0" "50.8" "48.3" "59.2" "151.4" "78.3" "51.9" "93.4" "53.9" "87.0" "342.5" "600.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N3I7" "Bardet-Biedl syndrome 5 protein OS=Homo sapiens OX=9606 GN=BBS5 PE=1 SV=1" "9" "2" "5" "2" "341" "38.7" "5.60" "1110.68" "12.62" "1" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf07289" "129880" "ENSG00000163093" "BBS5" "D3DPC3; hsa:129880; Q6PKN0; Q8N3I7" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "30.1" "23.8" "36.8" "84.5" "48.9" "34.6" "62.1" "38.1" "101.4" "308.7" "202.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46087" "Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "5" "4" "7" "4" "812" "89.2" "9.23" "1023.33" "12.57" "3" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Imatinib and chronic myeloid leukemia" "3" "0" "555.9" "387.4" "510.1" "995.1" "640.9" "481.6" "690.0" "311.6" "526.0" "1090.1" "828.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "6" "4" "7" "4" "938" "102.9" "7.02" "2002.22" "12.56" "4" "3" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "309.0" "261.2" "339.7" "603.2" "395.7" "268.7" "416.6" "347.0" "373.3" "545.5" "369.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16795" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA9 PE=1 SV=2" "12" "3" "6" "3" "377" "42.5" "9.80" "1371.16" "12.55" "3" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01370" "4704" "ENSG00000139180" "NDUFA9" "hsa:4704; Q14076; Q16795; Q2NKX0" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "46.5" "42.0" "72.2" "280.1" "102.5" "60.2" "79.9" "50.3" "64.9" "184.7" "178.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "7" "5" "8" "4" "858" "96.8" "5.39" "1196.46" "12.53" "4" "4" "stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "" "2" "0" "235.8" "185.5" "269.4" "771.2" "378.0" "184.7" "322.1" "197.1" "302.8" "661.7" "526.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14654" "Insulin receptor substrate 4 OS=Homo sapiens OX=9606 GN=IRS4 PE=1 SV=1" "4" "5" "7" "5" "1257" "133.7" "8.44" "799.12" "12.50" "3" "4" "signal transduction" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf02174" "8471" "ENSG00000133124" "IRS4" "hsa:8471; O14654" "IRS-related events triggered by IGF1R" "Alzheimer's disease and miRNA effects; Adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; Insulin signaling; Alzheimer's disease" "8" "0" "656.6" "504.0" "721.8" "1413.0" "876.1" "638.7" "1003.7" "525.9" "740.0" "2008.3" "1594.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "19" "4" "8" "4" "240" "26.8" "4.73" "1512.34" "12.49" "4" "4" "cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; hsa:3068; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "XBP1(S) activates chaperone genes" "IL-18 signaling pathway" "2" "0" "267.6" "239.4" "366.6" "1707.3" "603.0" "187.5" "326.9" "255.3" "293.3" "483.0" "366.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "9" "3" "5" "3" "534" "60.9" "8.44" "682.27" "12.49" "2" "3" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "71.9" "76.7" "100.8" "338.1" "144.5" "88.0" "163.5" "109.6" "120.3" "448.2" "497.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "5" "4" "7" "4" "1007" "113.5" "9.16" "1973.23" "12.32" "4" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "0" "295.6" "241.2" "347.3" "745.0" "443.2" "294.9" "566.2" "221.4" "341.0" "719.6" "472.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "13" "3" "5" "3" "392" "43.1" "6.29" "802.25" "12.31" "2" "3" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Primary ovarian insufficiency" "3" "0" "71.9" "83.4" "132.8" "329.5" "191.6" "136.8" "277.5" "132.2" "146.3" "610.4" "404.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "29" "2" "6" "2" "91" "10.8" "10.73" "1318.36" "12.31" "2" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "2" "0" "71.2" "76.1" "92.3" "379.7" "148.0" "98.2" "188.5" "167.4" "382.5" "1121.6" "955.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "15" "2" "6" "2" "222" "23.8" "8.38" "1265.73" "12.29" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Senescence-Associated Secretory Phenotype (SASP); Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "19" "0" "54.9" "61.3" "84.5" "214.1" "92.2" "76.4" "123.2" "85.3" "145.8" "705.7" "1007.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "11" "3" "5" "3" "459" "48.8" "7.66" "819.41" "12.22" "2" "3" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "hsa:54995; Q9NWU1" "" "Mitochondrial fatty acid synthesis pathway" "1" "0" "46.3" "38.3" "49.7" "131.0" "65.3" "47.3" "72.6" "44.8" "108.3" "621.7" "675.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "19" "4" "8" "4" "227" "26.2" "8.82" "1448.64" "12.20" "4" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "415.7" "354.2" "449.2" "1318.7" "627.3" "403.4" "613.8" "423.8" "463.9" "1049.4" "868.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08670" "Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4" "16" "6" "10" "6" "466" "53.6" "5.12" "2396.19" "12.20" "6" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf04732" "7431" "ENSG00000026025" "VIM" "B0YJC2; D3DRU4; hsa:7431; P08670; Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3" "Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins" "Allograft rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; TROP2 regulatory signaling; CKAP4 signaling pathway map; A network map of Macrophage-stimulating protein (MSP) signaling; T-cell receptor signaling pathway" "21" "0" "187.3" "173.7" "238.8" "661.7" "319.1" "194.5" "349.7" "212.8" "236.2" "742.2" "527.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "12" "3" "4" "3" "376" "42.6" "6.64" "355.64" "12.15" "1" "3" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "11" "0" "62.3" "59.2" "86.3" "284.3" "117.7" "60.7" "107.7" "70.7" "88.5" "263.1" "206.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "8" "4" "7" "4" "563" "65.1" "5.05" "1098.56" "12.13" "3" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "mRNA Splicing - Major Pathway" "" "1" "0" "80.0" "77.2" "111.2" "295.5" "168.0" "99.0" "191.7" "131.8" "114.4" "808.6" "1419.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P01111" "GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1" "12" "2" "8" "2" "189" "21.2" "5.17" "1501.45" "12.12" "2" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00071" "4893" "ENSG00000213281" "NRAS" "hsa:4893; P01111; Q14971; Q15104; Q15282" "FCERI mediated MAPK activation; Regulation of RAS by GAPs; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants" "Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; JAK-STAT signaling in the regulation of Beta-cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "108" "0" "116.7" "90.2" "153.4" "355.3" "190.5" "136.1" "236.6" "148.2" "230.3" "693.6" "747.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "5" "2" "6" "2" "638" "71.4" "5.20" "1346.31" "12.11" "2" "2" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "Separation of Sister Chromatids; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein" "21" "0" "88.2" "81.2" "122.6" "228.8" "132.4" "83.2" "153.4" "81.3" "103.7" "260.1" "192.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "29" "3" "5" "3" "164" "19.3" "11.65" "989.81" "12.10" "2" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "6" "0" "314.5" "310.8" "366.2" "1107.1" "474.3" "252.5" "581.4" "367.0" "301.5" "800.1" "546.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "8" "3" "5" "3" "616" "68.1" "7.21" "973.78" "12.06" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "Regulation of TP53 Activity through Phosphorylation; Fanconi Anemia Pathway; SUMOylation of DNA damage response and repair proteins; Regulation of HSF1-mediated heat shock response; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Retinoblastoma gene in cancer; ATR signaling; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "39" "0" "100.2" "81.8" "145.2" "643.0" "258.5" "91.8" "196.2" "104.3" "156.4" "363.1" "240.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14315" "Filamin-C OS=Homo sapiens OX=9606 GN=FLNC PE=1 SV=3" "1" "4" "6" "1" "2725" "290.8" "5.97" "808.35" "12.03" "2" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2318" "ENSG00000128591" "FLNC" "B2ZZ88; hsa:2318; O95303; Q07985; Q14315; Q9NS12; Q9NYE5; Q9UMR8; Q9Y503" "Cell-extracellular matrix interactions" "Focal adhesion; MAPK signaling pathway; Ebola virus infection in host" "4" "0" "14.0" "16.6" "21.2" "47.3" "32.4" "19.9" "24.2" "12.7" "8.3" "21.8" "16.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13613" "Myotubularin-related protein 1 OS=Homo sapiens OX=9606 GN=MTMR1 PE=1 SV=4" "5" "3" "7" "3" "665" "74.6" "7.14" "877.78" "11.95" "2" "3" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf02893, Pf06602" "8776" "ENSG00000063601" "MTMR1" "A0A024RC07; hsa:8776; Q13613; Q9UBX6; Q9UEM0; Q9UQD5" "RHOF GTPase cycle; Synthesis of PIPs at the plasma membrane" "" "2" "0" "53.1" "48.5" "66.4" "179.1" "99.2" "68.6" "134.2" "134.6" "306.8" "1667.5" "1273.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "18" "4" "8" "4" "224" "25.0" "6.38" "1554.37" "11.94" "4" "4" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "5" "0" "179.2" "172.9" "327.2" "1790.1" "559.6" "125.1" "357.3" "275.2" "207.6" "756.7" "680.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "3" "4" "8" "4" "1729" "181.7" "4.86" "1280.86" "11.93" "4" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "Ciliary landscape" "3" "0" "66.6" "57.5" "68.9" "187.3" "89.0" "58.7" "101.1" "61.3" "74.2" "261.4" "198.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HD33" "39S ribosomal protein L47, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "15" "4" "8" "4" "250" "29.4" "10.37" "1164.81" "11.86" "4" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "119.3" "130.3" "155.1" "654.3" "229.4" "112.9" "214.7" "149.5" "164.4" "517.9" "473.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "6" "3" "5" "3" "655" "74.3" "6.16" "682.01" "11.84" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "Maturation of nucleoprotein" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "166.7" "133.3" "170.7" "397.7" "227.3" "167.0" "268.9" "130.9" "155.3" "486.2" "357.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "19" "3" "8" "3" "196" "22.2" "5.57" "1250.19" "11.83" "3" "3" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "50.0" "47.2" "91.3" "422.9" "154.2" "32.8" "70.1" "65.3" "64.3" "107.3" "97.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "4" "4" "9" "4" "971" "110.3" "5.77" "1641.79" "11.80" "4" "3" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "183.3" "180.5" "246.3" "1309.8" "416.4" "149.0" "296.2" "224.8" "220.2" "765.7" "817.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "3" "3" "5" "3" "2240" "243.7" "7.88" "1003.55" "11.80" "2" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "40.9" "35.0" "54.3" "99.6" "79.7" "42.9" "91.5" "41.6" "50.1" "98.9" "72.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "23" "2" "6" "2" "102" "11.5" "4.16" "1162.12" "11.80" "2" "2" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "" "IL-18 signaling pathway" "1" "0" "204.4" "197.9" "274.9" "1092.3" "428.9" "169.2" "184.1" "177.0" "165.3" "165.0" "157.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "36" "4" "10" "3" "64" "7.1" "9.99" "1740.54" "11.75" "4" "3" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "2141.9" "1198.6" "1422.6" "1591.1" "1703.0" "1337.0" "2020.3" "1009.8" "1609.0" "2421.8" "1866.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "14" "2" "6" "2" "210" "23.3" "5.64" "1090.16" "11.67" "2" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species; Paracetamol ADME; Glutathione conjugation" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "10" "0" "55.2" "68.6" "111.5" "762.6" "213.6" "47.6" "96.2" "92.2" "84.9" "263.6" "284.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P32322" "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" "18" "4" "6" "3" "319" "33.3" "7.61" "1118.79" "11.65" "3" "3" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "5831" "ENSG00000183010" "PYCR1" "A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4" "Glutamate and glutamine metabolism" "Amino acid metabolism; Metabolic reprogramming in colon cancer" "3" "0" "93.6" "86.9" "114.0" "252.3" "145.2" "111.4" "174.8" "92.2" "117.2" "252.3" "200.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "9" "3" "5" "3" "480" "52.6" "6.37" "700.21" "11.64" "2" "3" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "93.8" "105.7" "153.7" "754.0" "211.5" "78.7" "182.0" "128.4" "154.9" "412.6" "391.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5S2" "Serine/threonine-protein kinase MRCK beta OS=Homo sapiens OX=9606 GN=CDC42BPB PE=1 SV=2" "4" "5" "7" "5" "1711" "194.2" "6.37" "1036.69" "11.61" "3" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00780, Pf08826, Pf15796" "9578" "ENSG00000198752" "CDC42BPB" "A9JR72; hsa:9578; Q2L7A5; Q86TJ1; Q9ULU5; Q9Y5S2" "CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "VEGFA-VEGFR2 signaling" "4" "0" "77.8" "77.5" "110.4" "239.7" "117.8" "84.7" "169.9" "126.6" "235.6" "1135.1" "1391.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "7" "3" "6" "3" "578" "63.7" "7.36" "1180.73" "11.61" "3" "3" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "Peroxisomal protein import; Alpha-oxidation of phytanate" "" "2" "0" "137.2" "106.8" "145.0" "451.0" "219.6" "146.5" "280.5" "167.6" "195.3" "964.6" "1047.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNQ2" "Probable dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "17" "4" "7" "4" "313" "35.2" "9.99" "911.07" "11.42" "3" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "hsa:27292; O76025; Q9BU77; Q9UES1; Q9UNQ2" "rRNA modification in the nucleus and cytosol" "" "1" "0" "233.2" "208.6" "259.9" "557.2" "314.8" "216.9" "344.1" "226.5" "257.0" "510.3" "428.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "2" "2" "6" "2" "1129" "125.9" "5.62" "1037.25" "11.41" "2" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "" "Mesodermal commitment pathway" "1" "0" "114.9" "96.9" "109.4" "207.6" "139.5" "99.3" "136.1" "71.1" "106.6" "254.3" "198.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "10" "4" "6" "4" "499" "55.4" "5.78" "919.63" "11.41" "3" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "mRNA Splicing - Major Pathway" "" "1" "0" "286.6" "223.2" "299.4" "456.9" "375.7" "248.6" "366.4" "221.5" "327.4" "527.2" "356.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "6" "3" "7" "3" "587" "63.5" "4.68" "1295.91" "11.41" "3" "3" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "12" "0" "46.4" "45.1" "74.3" "465.2" "134.0" "19.5" "84.4" "82.1" "60.9" "205.5" "222.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "9" "3" "4" "3" "450" "50.8" "7.43" "433.48" "11.39" "1" "3" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "37.3" "34.4" "49.1" "110.8" "49.3" "41.4" "65.2" "35.0" "69.4" "228.3" "342.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y281" "Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1" "35" "5" "9" "1" "166" "18.7" "7.88" "1935.33" "11.39" "5" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1073" "ENSG00000165410" "CFL2" "G3V5P4; hsa:1073; Q9Y281" "" "Leptin signaling pathway; Microtubule cytoskeleton regulation; Regulation of actin cytoskeleton; G13 signaling pathway" "4" "0" "20.2" "26.7" "35.4" "165.9" "55.9" "24.9" "37.8" "22.7" "20.8" "62.9" "52.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "8" "4" "9" "4" "452" "50.9" "8.69" "1519.51" "11.35" "4" "3" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle)" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "6" "0" "173.6" "158.0" "185.6" "355.6" "236.0" "172.5" "236.9" "105.3" "161.5" "293.9" "250.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31483" "Nucleolysin TIA-1 isoform p40 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "11" "4" "8" "2" "386" "42.9" "7.74" "1382.97" "11.30" "4" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "FGFR2 alternative splicing" "" "1" "2" "303.7" "281.5" "455.0" "1032.8" "492.8" "265.7" "767.6" "343.6" "427.9" "1366.3" "864.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02413" "Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2" "3" "2" "4" "2" "1049" "113.7" "5.03" "996.18" "11.27" "2" "2" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00028, Pf01049" "1828" "ENSG00000134760" "DSG1" "B7Z845; hsa:1828; Q02413" "Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; Apoptotic cleavage of cell adhesion proteins; RND2 GTPase cycle" "" "6" "0" "137.9" "118.5" "90.0" "134.4" "75.7" "55.7" "103.1" "37.3" "57.2" "115.6" "65.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "8" "2" "4" "2" "465" "52.8" "6.70" "322.19" "11.24" "1" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; hsa:84864; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "HDMs demethylate histones" "" "1" "0" "12.0" "12.1" "9.8" "25.1" "21.2" "5.7" "16.1" "11.3" "15.1" "79.3" "75.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "1" "2" "6" "2" "1697" "193.3" "8.12" "1067.46" "11.24" "2" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "hsa:50618; O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "" "3" "0" "37.2" "33.4" "53.4" "236.8" "95.6" "44.2" "88.1" "65.3" "124.0" "553.9" "434.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00746" "Nucleoside diphosphate kinase, mitochondrial OS=Homo sapiens OX=9606 GN=NME4 PE=1 SV=1" "16" "2" "6" "2" "187" "20.6" "10.29" "1328.15" "11.23" "2" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00334" "4833" "ENSG00000103202" "NME4" "A2IDD0; hsa:4833; O00746; Q5U0M9" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "64.1" "61.5" "62.9" "133.7" "83.4" "75.7" "102.6" "41.6" "82.4" "278.6" "213.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "13" "4" "8" "4" "261" "29.5" "7.72" "1201.63" "11.20" "4" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "63" "0" "673.3" "569.3" "654.9" "1970.2" "887.8" "443.1" "849.6" "449.8" "532.8" "1574.0" "1375.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "34" "3" "4" "3" "195" "19.5" "4.67" "410.62" "11.17" "1" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "36.3" "20.0" "36.4" "176.7" "65.1" "31.2" "43.8" "20.7" "25.2" "91.8" "100.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4P3" "Transducin beta-like protein 2 OS=Homo sapiens OX=9606 GN=TBL2 PE=1 SV=1" "5" "2" "6" "2" "447" "49.8" "9.44" "1224.49" "11.16" "2" "2" "stress response;signal transduction" "other membranes;ER/Golgi" "other molecular function" "Pf00400" "26608" "ENSG00000106638" "TBL2" "hsa:26608; Q9UQE2; Q9Y4P3" "" "7q11.23 copy number variation syndrome" "1" "0" "278.9" "240.4" "316.5" "708.2" "390.3" "247.9" "515.4" "236.4" "288.2" "1061.3" "858.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96HS1" "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" "11" "3" "8" "3" "289" "32.0" "8.68" "1235.81" "11.14" "3" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;other molecular function" "Pf00300" "192111" "ENSG00000247077" "PGAM5" "A9LN06; C9IZY7; hsa:192111; Q96HS1; Q96JB0" "" "NRF2-ARE regulation" "1" "0" "184.0" "160.2" "219.2" "997.4" "347.8" "177.8" "399.4" "255.1" "242.4" "1184.4" "996.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "23" "4" "8" "4" "168" "19.7" "8.43" "1369.28" "11.12" "4" "4" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "164.9" "124.8" "195.9" "478.3" "250.5" "143.5" "273.5" "157.6" "297.8" "1652.7" "3014.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "6" "4" "8" "4" "664" "72.6" "7.39" "1240.34" "11.11" "4" "4" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "358.4" "289.0" "427.3" "987.9" "537.6" "270.7" "537.0" "356.8" "483.2" "923.2" "764.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "2" "3" "5" "3" "2376" "266.8" "7.11" "728.43" "11.10" "2" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "Ciliary landscape" "3" "0" "65.1" "67.4" "87.7" "248.6" "116.5" "78.7" "121.7" "72.3" "103.0" "470.9" "526.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "13" "3" "6" "3" "299" "33.4" "5.25" "1210.07" "11.06" "3" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "164.4" "162.7" "241.7" "756.5" "336.1" "180.0" "332.7" "195.7" "247.2" "731.6" "860.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "6" "1" "4" "1" "191" "21.2" "6.55" "518.60" "11.05" "1" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHOU GTPase cycle; DCC mediated attractive signaling; GPVI-mediated activation cascade; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "60" "0" "128.1" "119.0" "180.5" "708.9" "272.1" "131.3" "277.2" "194.1" "393.5" "1719.7" "1435.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16658" "Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3" "8" "3" "7" "3" "493" "54.5" "7.24" "1510.65" "11.04" "3" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf06268" "6624" "ENSG00000075618" "FSCN1" "A6NI89; B2RE97; hsa:6624; Q16658; Q96IC5; Q96IH1; Q9BRF1" "Interleukin-4 and Interleukin-13 signaling" "VEGFA-VEGFR2 signaling; Urotensin-II-mediated signaling pathway" "3" "0" "66.3" "86.2" "112.8" "692.9" "214.3" "45.2" "92.4" "116.8" "68.6" "183.4" "224.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "2" "4" "7" "3" "2229" "242.8" "8.34" "1291.88" "11.04" "4" "3" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "137.3" "107.8" "132.9" "254.4" "176.6" "132.3" "207.1" "94.8" "148.7" "263.0" "145.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "9" "6" "13" "3" "577" "67.8" "6.40" "2711.06" "11.02" "6" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "10" "1" "317.4" "305.2" "430.7" "1844.0" "640.6" "235.2" "321.8" "268.5" "314.3" "692.3" "879.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "31" "3" "7" "3" "100" "10.7" "9.60" "1072.85" "11.01" "2" "3" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "235.8" "187.1" "208.1" "429.9" "285.9" "189.1" "288.0" "160.2" "276.9" "1141.3" "1916.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "5" "5" "9" "5" "1369" "155.1" "8.09" "1659.47" "11.01" "4" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "" "VEGFA-VEGFR2 signaling" "1" "0" "138.6" "125.0" "130.5" "258.3" "156.8" "126.4" "232.0" "101.4" "136.1" "461.9" "369.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86WG5" "Myotubularin-related protein 13 OS=Homo sapiens OX=9606 GN=SBF2 PE=1 SV=1" "2" "3" "6" "2" "1849" "208.3" "7.06" "1284.41" "10.98" "3" "3" "other metabolic processes;developmental processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "81846" "ENSG00000133812" "SBF2" "hsa:81846; Q3MJF0; Q68DQ3; Q6P459; Q6PJD1; Q7Z325; Q7Z621; Q86VE2; Q86WG5; Q96FE2; Q9C097" "Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs" "Intracellular trafficking proteins involved in CMT neuropathy" "3" "0" "5.6" "7.9" "9.1" "32.7" "13.7" "9.1" "15.9" "10.9" "19.2" "206.2" "230.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "8" "3" "4" "3" "515" "59.2" "6.84" "340.11" "10.97" "1" "3" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "16" "0" "130.7" "122.8" "196.9" "689.2" "233.5" "103.6" "265.3" "147.1" "186.9" "472.6" "467.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "12" "4" "6" "4" "365" "41.3" "8.68" "1043.62" "10.97" "3" "3" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "" "Mesodermal commitment pathway" "1" "0" "184.0" "177.6" "195.3" "482.0" "245.0" "154.4" "280.9" "195.2" "197.5" "1412.9" "2728.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "6" "4" "8" "1" "583" "68.5" "6.37" "1274.58" "10.88" "4" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "Regulation of actin cytoskeleton" "4" "0" "37.1" "34.9" "59.0" "201.7" "87.3" "30.9" "46.6" "36.3" "43.8" "113.2" "140.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "10" "3" "5" "3" "468" "50.1" "7.06" "761.71" "10.88" "2" "3" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Regulation of HSF1-mediated heat shock response; snRNP Assembly; ISG15 antiviral mechanism; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Early Events; HCMV Late Events; Transcriptional regulation by small RNAs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "34.7" "34.8" "46.4" "226.6" "77.8" "25.8" "54.6" "46.0" "46.8" "153.6" "157.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPY6" "Wiskott-Aldrich syndrome protein family member 3 OS=Homo sapiens OX=9606 GN=WASF3 PE=1 SV=2" "5" "2" "6" "1" "502" "55.3" "6.43" "1258.81" "10.85" "2" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10810" "ENSG00000132970" "WASF3" "hsa:10810; O94974; Q86VQ2; Q9UPY6" "Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "" "5" "0" "11.4" "9.6" "10.2" "20.7" "11.6" "10.4" "15.7" "9.3" "14.7" "29.3" "29.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P015" "39S ribosomal protein L15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "13" "3" "6" "3" "296" "33.4" "10.01" "1135.83" "10.82" "3" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "151.0" "151.3" "182.9" "615.8" "260.1" "167.9" "263.2" "175.1" "188.7" "650.4" "627.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "5" "2" "5" "2" "530" "60.1" "9.13" "894.54" "10.81" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "Vpr-mediated nuclear import of PICs; Formation of WDR5-containing histone-modifying complexes; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "MECP2 and associated Rett syndrome" "8" "0" "212.0" "165.5" "235.0" "652.4" "288.8" "189.6" "314.2" "161.2" "241.4" "693.9" "908.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZF1" "Oxysterol-binding protein-related protein 8 OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=3" "5" "3" "6" "3" "889" "101.1" "6.96" "1004.35" "10.77" "3" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114882" "ENSG00000091039" "OSBPL8" "A8K1T2; E9PE66; E9PE68; hsa:114882; Q52LQ3; Q68D75; Q8WXP8; Q9BZF1; Q9P277" "Acyl chain remodelling of PS" "" "1" "0" "23.7" "32.7" "42.9" "99.5" "42.2" "27.2" "49.5" "33.8" "43.8" "207.7" "234.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61011" "Signal recognition particle 54 kDa protein OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "8" "3" "6" "3" "504" "55.7" "8.75" "1219.81" "10.76" "3" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "SRP-dependent cotranslational protein targeting to membrane" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "66.8" "79.2" "112.5" "378.0" "152.1" "75.3" "125.1" "102.2" "120.8" "313.5" "307.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "10" "5" "10" "5" "437" "49.0" "5.71" "2181.86" "10.75" "5" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Translation factors" "5" "0" "252.7" "207.3" "261.0" "1050.7" "350.8" "200.3" "563.1" "217.5" "277.9" "1767.9" "1514.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "10" "3" "6" "3" "330" "37.4" "10.01" "1415.26" "10.75" "3" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "602.0" "492.3" "668.5" "1871.6" "927.3" "527.1" "833.7" "525.8" "535.0" "915.1" "650.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48047" "ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1" "16" "3" "6" "3" "213" "23.3" "9.96" "1259.79" "10.73" "3" "3" "other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion" "transporter activity" "Pf00213" "539" "ENSG00000241837" "ATP5PO" "B2R4E2; hsa:539; P48047; Q5U042; Q6IBI2" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "170.0" "169.5" "273.2" "1100.7" "397.6" "151.2" "366.6" "228.7" "335.5" "952.0" "1047.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "23" "2" "6" "2" "95" "10.9" "5.50" "1071.89" "10.73" "2" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "Formation of Incision Complex in GG-NER; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "" "14" "0" "121.6" "119.1" "198.4" "1185.0" "326.9" "44.9" "161.3" "138.5" "185.6" "762.8" "977.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "14" "5" "9" "5" "280" "31.6" "8.76" "1385.07" "10.72" "5" "4" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "454.7" "388.4" "606.1" "1560.9" "760.2" "390.2" "757.2" "435.1" "545.8" "1251.5" "1079.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "3" "3" "5" "3" "1555" "177.1" "5.63" "711.41" "10.70" "2" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "ER Quality Control Compartment (ERQC)" "IL-18 signaling pathway" "2" "0" "111.3" "91.4" "117.5" "265.0" "142.8" "105.7" "218.0" "68.5" "99.2" "341.4" "178.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "10" "3" "6" "3" "377" "40.7" "4.79" "1135.33" "10.68" "3" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "64" "0" "203.5" "190.9" "255.5" "888.7" "370.0" "212.3" "450.5" "256.3" "291.5" "908.9" "1068.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "21" "3" "10" "3" "151" "16.3" "5.67" "1781.46" "10.64" "3" "2" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "8" "0" "130.0" "120.0" "128.9" "303.5" "167.9" "123.1" "184.8" "136.4" "187.3" "1094.9" "1825.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "5" "2" "6" "2" "551" "62.1" "8.40" "1045.09" "10.64" "2" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "ISG15 antiviral mechanism; Interferon alpha/beta signaling; Inhibition of PKR" "Translation factors; Alzheimer's disease and miRNA effects; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "12" "0" "119.7" "108.4" "139.6" "314.7" "187.0" "125.1" "235.3" "127.5" "172.1" "651.0" "667.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "6" "3" "5" "3" "500" "53.9" "8.66" "803.75" "10.60" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf07690" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Basigin interactions; Pyruvate metabolism; Aspirin ADME; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "8" "0" "132.7" "102.1" "139.3" "273.0" "188.2" "134.2" "201.0" "92.2" "140.7" "305.7" "226.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "14" "4" "8" "4" "258" "28.8" "6.65" "1110.87" "10.58" "4" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "73.1" "68.6" "108.9" "237.8" "139.8" "141.4" "263.2" "278.6" "536.9" "1386.6" "1227.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P24539" "ATP synthase F(0) complex subunit B1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PB PE=1 SV=2" "13" "3" "6" "3" "256" "28.9" "9.36" "1067.22" "10.58" "3" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05405" "515" "ENSG00000116459" "ATP5PB" "hsa:515; P24539; Q9BQ68; Q9BRU8" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "136.8" "122.3" "193.9" "826.2" "295.6" "135.1" "235.9" "157.5" "215.1" "672.3" "730.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "4" "3" "6" "3" "950" "108.5" "7.47" "1226.41" "10.52" "3" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "mRNA processing" "3" "0" "211.2" "189.9" "300.4" "862.7" "389.8" "241.4" "486.1" "209.5" "294.1" "859.2" "592.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UL54" "Serine/threonine-protein kinase TAO2 OS=Homo sapiens OX=9606 GN=TAOK2 PE=1 SV=2" "3" "3" "6" "2" "1235" "138.2" "7.27" "1087.42" "10.51" "3" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "9344" "ENSG00000149930" "TAOK2" "A5PKY1; A7MCZ2; B2RN35; B7ZM88; hsa:9344; O94957; Q6UW73; Q7LC09; Q9NSW2; Q9UL54" "" "MAPK signaling pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "3" "0" "60.0" "59.2" "74.9" "252.7" "99.2" "68.1" "106.6" "77.4" "94.2" "337.6" "313.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "28" "3" "8" "3" "139" "15.3" "9.99" "1875.34" "10.51" "3" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "Ciliary landscape" "3" "0" "208.0" "199.7" "286.2" "934.6" "423.1" "193.3" "384.0" "254.4" "272.2" "850.9" "721.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRV9" "Heme-binding protein 1 OS=Homo sapiens OX=9606 GN=HEBP1 PE=1 SV=1" "25" "3" "5" "3" "189" "21.1" "5.80" "392.98" "10.48" "1" "3" "other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf04832" "50865" "ENSG00000013583" "HEBP1" "A8K1G2; hsa:50865; Q9NRV9; Q9Y5Z5" "G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands" "" "2" "0" "134.3" "93.7" "165.0" "380.7" "211.1" "97.2" "215.6" "157.5" "189.6" "446.3" "336.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "27" "2" "6" "2" "99" "11.2" "4.88" "1251.51" "10.46" "2" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "Kleefstra syndrome" "5" "0" "91.0" "75.6" "117.9" "380.7" "160.1" "95.3" "185.8" "105.1" "130.0" "328.7" "257.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "15" "4" "4" "4" "475" "51.9" "8.06" "569.15" "10.41" "1" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "7" "0" "115.2" "110.2" "150.3" "644.6" "244.8" "108.3" "138.8" "119.1" "108.0" "248.8" "187.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95400" "CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1" "13" "4" "8" "4" "341" "37.6" "4.61" "2115.00" "10.41" "4" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02213" "10421" "ENSG00000169217" "CD2BP2" "B2RDX2; hsa:10421; O95400; Q9ULP2" "" "mRNA processing; Ciliary landscape" "2" "0" "329.5" "286.0" "361.8" "801.4" "461.2" "356.9" "648.8" "335.8" "386.0" "1327.9" "1138.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "10" "3" "5" "3" "424" "44.4" "8.56" "544.64" "10.40" "2" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "133.3" "168.1" "219.7" "769.8" "390.2" "186.2" "431.7" "261.0" "267.8" "775.4" "654.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKE5" "TRAF2 and NCK-interacting protein kinase OS=Homo sapiens OX=9606 GN=TNIK PE=1 SV=1" "3" "4" "7" "1" "1360" "154.8" "7.17" "874.89" "10.36" "3" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "23043" "ENSG00000154310" "TNIK" "A7E2A3; A8K4U1; D3DNQ6; hsa:23043; O60298; Q8WUY7; Q9UKD8; Q9UKD9; Q9UKE0; Q9UKE1; Q9UKE2; Q9UKE3; Q9UKE4; Q9UKE5" "Oxidative Stress Induced Senescence" "Hippo-YAP signaling; Pleural mesothelioma" "3" "0" "33.2" "28.4" "43.8" "109.4" "54.7" "37.8" "55.8" "64.1" "118.6" "325.2" "263.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TAE8" "Growth arrest and DNA damage-inducible proteins-interacting protein 1 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "14" "2" "6" "2" "222" "25.4" "10.02" "939.95" "10.33" "2" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "82.5" "76.7" "110.2" "242.3" "143.9" "98.1" "154.5" "99.8" "201.5" "506.9" "372.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "33" "3" "6" "3" "109" "12.3" "10.24" "894.70" "10.31" "3" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "" "" "0" "0" "56.1" "61.0" "96.0" "362.9" "156.2" "62.7" "114.8" "74.6" "94.0" "268.1" "185.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H267" "Vacuolar protein sorting-associated protein 33B OS=Homo sapiens OX=9606 GN=VPS33B PE=1 SV=2" "6" "2" "3" "2" "617" "70.5" "6.71" "448.84" "10.29" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "26276" "ENSG00000184056" "VPS33B" "B3KQF6; hsa:26276; Q96K14; Q9H267; Q9NRP6; Q9NSF3" "Prevention of phagosomal-lysosomal fusion; SARS-CoV-2 modulates autophagy" "" "2" "0" "16.0" "13.1" "21.6" "41.8" "24.5" "22.5" "40.1" "24.2" "28.2" "86.1" "66.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "27" "4" "8" "4" "160" "18.7" "4.54" "1712.86" "10.27" "4" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "11" "0" "283.2" "260.5" "405.2" "2293.4" "650.8" "200.8" "432.4" "315.5" "309.0" "676.7" "547.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQ50" "39S ribosomal protein L40, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" "16" "2" "4" "2" "206" "24.5" "9.63" "1187.86" "10.24" "2" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf09812" "64976" "ENSG00000185608" "MRPL40" "B3KVZ7; hsa:64976; O95134; Q9NQ50" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "22q11.2 copy number variation syndrome" "4" "0" "38.0" "36.5" "63.8" "146.5" "58.2" "40.8" "80.9" "45.8" "54.0" "157.3" "185.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "2" "3" "6" "3" "1362" "152.1" "9.19" "1146.97" "10.23" "3" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "Potential therapeutics for SARS" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "0" "113.0" "98.5" "97.4" "238.0" "161.1" "111.7" "169.4" "80.1" "118.6" "284.4" "260.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62891" "60S ribosomal protein L39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2" "35" "2" "5" "2" "51" "6.4" "12.56" "775.21" "10.19" "1" "2" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00832" "6170" "ENSG00000198918" "RPL39" "hsa:6170; P02404; P39025; P62891; Q9BYF2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "466.1" "372.2" "602.6" "1081.0" "943.8" "803.8" "1335.0" "360.9" "697.3" "789.0" "339.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "5" "2" "3" "2" "628" "68.7" "5.69" "460.06" "10.18" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Deactivation of the beta-catenin transactivating complex; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Kleefstra syndrome" "7" "0" "62.8" "52.6" "72.1" "145.8" "80.9" "53.5" "76.3" "32.3" "56.4" "117.1" "86.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P98082" "Disabled homolog 2 OS=Homo sapiens OX=9606 GN=DAB2 PE=1 SV=3" "6" "3" "5" "3" "770" "82.4" "5.53" "557.28" "10.17" "2" "3" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00640" "1601" "ENSG00000153071" "DAB2" "A6NES5; hsa:1601; P98082; Q13598; Q9BTY0; Q9UK04" "Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions" "Endoderm differentiation" "5" "0" "19.2" "21.4" "18.8" "45.8" "29.5" "19.0" "39.2" "44.6" "87.6" "419.2" "447.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "19" "4" "7" "4" "273" "29.3" "8.18" "1444.84" "10.17" "4" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "Ion transport by P-type ATPases" "" "1" "0" "202.3" "163.1" "235.1" "468.2" "267.9" "199.6" "389.4" "170.5" "261.9" "829.2" "807.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "9" "4" "7" "4" "370" "40.4" "7.66" "1261.10" "10.16" "4" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "7" "0" "265.5" "345.2" "565.5" "4088.0" "1127.6" "98.7" "310.5" "468.5" "297.8" "596.9" "787.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "4" "3" "5" "3" "1243" "140.3" "8.22" "885.97" "10.16" "2" "3" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "123.2" "103.1" "116.5" "171.7" "152.3" "112.5" "155.8" "95.3" "133.7" "314.3" "322.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "24" "3" "6" "3" "118" "13.1" "4.88" "1215.89" "10.14" "3" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "21" "0" "344.3" "288.1" "472.3" "1351.0" "641.2" "363.3" "670.2" "358.2" "450.5" "1018.4" "776.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "15" "4" "7" "4" "255" "27.8" "8.10" "1514.44" "10.12" "4" "3" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "Respiratory electron transport; Protein methylation" "" "2" "0" "44.2" "45.8" "69.5" "481.4" "117.1" "14.0" "59.1" "56.1" "42.4" "108.5" "142.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "2" "4" "8" "4" "953" "106.3" "8.32" "1112.10" "10.11" "3" "4" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "1006.5" "715.0" "1031.8" "1029.7" "1043.0" "708.6" "1452.8" "696.4" "1036.8" "1299.3" "765.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "30" "4" "6" "3" "183" "20.8" "5.33" "1660.11" "10.06" "3" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "RNA Polymerase I Promoter Escape; Transcriptional Regulation by E2F6; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Exercise-induced circadian regulation; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "6" "1" "166.9" "152.8" "274.7" "1849.3" "436.5" "103.8" "270.1" "169.0" "215.8" "546.0" "425.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "18" "5" "8" "5" "331" "38.2" "5.38" "1806.12" "10.04" "5" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; RND2 GTPase cycle" "Ciliary landscape" "8" "0" "380.7" "375.7" "538.6" "1904.7" "764.2" "289.1" "517.8" "404.7" "416.9" "797.5" "655.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "6" "3" "6" "3" "622" "71.6" "7.31" "1139.32" "10.02" "3" "3" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "119.4" "101.9" "149.5" "390.1" "230.9" "106.5" "231.2" "119.8" "135.3" "491.6" "505.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "8" "3" "5" "3" "551" "59.2" "7.15" "617.87" "10.02" "2" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "68.0" "70.5" "90.7" "295.1" "113.1" "50.9" "103.5" "102.9" "87.2" "180.5" "255.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27708" "CAD protein OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "2" "3" "6" "3" "2225" "242.8" "6.46" "1033.28" "9.97" "3" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Pyrimidine biosynthesis" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "4" "0" "66.2" "65.0" "97.0" "310.9" "126.3" "65.4" "126.8" "89.1" "85.5" "278.9" "264.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O96000" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 OS=Homo sapiens OX=9606 GN=NDUFB10 PE=1 SV=3" "23" "3" "6" "3" "172" "20.8" "8.48" "1166.07" "9.96" "3" "3" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf10249" "4716" "ENSG00000140990" "NDUFB10" "hsa:4716; O96000; Q96II6" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation" "6" "0" "49.3" "57.5" "83.3" "378.6" "137.6" "45.7" "125.4" "84.0" "94.2" "243.0" "214.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "4" "2" "4" "2" "595" "69.6" "6.47" "309.45" "9.95" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "10" "0" "41.2" "47.7" "46.1" "116.3" "56.9" "44.2" "59.9" "45.9" "101.6" "1038.5" "1153.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2L5" "Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2" "3" "3" "4" "3" "1435" "160.9" "6.87" "614.06" "9.94" "2" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf12739" "22878" "ENSG00000153339" "TRAPPC8" "A0JP15; B3KME5; hsa:22878; Q9H0L2; Q9Y2L5" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "94.2" "76.4" "116.0" "259.4" "128.8" "106.4" "185.6" "103.1" "144.8" "534.1" "515.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "3" "3" "5" "3" "1294" "141.0" "8.40" "651.64" "9.92" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "7q11.23 copy number variation syndrome" "8" "0" "16.4" "25.4" "24.8" "66.9" "36.7" "24.6" "35.3" "28.8" "21.4" "58.0" "63.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "19" "4" "7" "4" "261" "26.9" "7.78" "1481.78" "9.92" "4" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Branched-chain amino acid catabolism; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "7" "0" "162.4" "169.8" "219.6" "877.2" "372.9" "184.0" "335.3" "217.2" "246.0" "750.0" "565.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "15" "4" "7" "4" "321" "33.8" "10.18" "1312.63" "9.89" "4" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "79.1" "68.9" "80.4" "206.9" "116.6" "73.6" "156.4" "107.0" "224.0" "989.8" "564.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TDN4" "CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens OX=9606 GN=CABLES1 PE=1 SV=2" "6" "3" "6" "3" "633" "67.6" "9.17" "1252.36" "9.87" "3" "3" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus" "" "Pf00134" "91768" "ENSG00000134508" "CABLES1" "B4DK60; hsa:91768; Q8N3Y8; Q8NA22; Q8TDN4; Q9BTG1" "Factors involved in megakaryocyte development and platelet production; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "" "3" "0" "0.0" "0.0" "0.0" "18.9" "7.0" "9.1" "49.1" "34.8" "58.7" "126.5" "85.8" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H7Z3" "Nuclear exosome regulator NRDE2 OS=Homo sapiens OX=9606 GN=NRDE2 PE=1 SV=3" "4" "4" "7" "4" "1164" "132.6" "7.68" "1332.81" "9.80" "4" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08424" "55051" "ENSG00000119720" "NRDE2" "B4DH71; hsa:55051; Q4G0A7; Q9H7Z3; Q9NWH6" "" "" "0" "0" "27.4" "27.7" "30.7" "97.2" "48.4" "30.2" "57.8" "32.0" "68.4" "425.7" "513.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "14" "3" "6" "3" "217" "24.3" "8.12" "935.37" "9.79" "3" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "Mitochondrial protein import" "" "1" "0" "147.0" "150.8" "246.2" "1555.4" "427.9" "116.9" "236.0" "186.5" "180.1" "556.1" "558.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "7" "4" "7" "4" "511" "57.2" "6.21" "1561.91" "9.76" "4" "3" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "miR-517 relationship with ARCN1 and USP1" "3" "0" "312.5" "265.1" "408.5" "1127.1" "529.8" "267.1" "599.3" "319.1" "363.0" "777.5" "542.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "13" "2" "3" "2" "262" "29.3" "9.79" "419.39" "9.71" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "Mitochondrial translation termination" "" "1" "0" "71.4" "55.2" "77.8" "197.2" "125.8" "66.2" "134.6" "74.6" "191.1" "973.4" "1107.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N4T8" "Carbonyl reductase family member 4 OS=Homo sapiens OX=9606 GN=CBR4 PE=1 SV=3" "8" "2" "6" "2" "237" "25.3" "9.33" "923.94" "9.71" "2" "2" "cell organization and biogenesis;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf13561" "84869" "ENSG00000145439" "CBR4" "hsa:84869; Q8N4T8; Q8WTW8; Q96K93" "Fatty acyl-CoA biosynthesis" "" "1" "0" "157.9" "128.4" "176.5" "328.4" "213.8" "168.2" "327.7" "160.7" "196.8" "702.7" "648.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "8" "3" "5" "3" "392" "42.9" "7.09" "810.38" "9.71" "2" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "" "2q37 copy number variation syndrome" "1" "0" "132.2" "118.1" "153.7" "432.8" "217.4" "126.0" "231.3" "149.8" "236.3" "900.4" "1291.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "4" "2" "4" "2" "843" "100.1" "6.32" "951.36" "9.70" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "mRNA Splicing - Major Pathway" "" "1" "0" "58.5" "60.5" "80.7" "210.9" "106.5" "66.3" "129.3" "69.1" "79.5" "350.1" "349.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IWF6" "Protein DENND6A OS=Homo sapiens OX=9606 GN=DENND6A PE=1 SV=1" "4" "2" "4" "2" "608" "69.5" "8.27" "1040.01" "9.70" "2" "2" "other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08616, Pf09794" "201627" "ENSG00000174839" "DENND6A" "hsa:201627; Q7Z5T4; Q8IWF6; Q8N235; Q8TEG8" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "27.2" "23.1" "24.3" "58.8" "33.2" "23.8" "47.0" "26.9" "50.0" "220.1" "270.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "10" "4" "8" "4" "182" "20.7" "8.69" "1667.50" "9.60" "4" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Platelet degranulation" "Orexin receptor pathway" "2" "0" "73.6" "73.8" "105.5" "262.6" "137.1" "78.0" "132.5" "97.1" "147.5" "670.4" "1069.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBP9" "PTB domain-containing engulfment adapter protein 1 OS=Homo sapiens OX=9606 GN=GULP1 PE=1 SV=1" "10" "3" "6" "3" "304" "34.5" "7.90" "982.02" "9.56" "3" "3" "cell organization and biogenesis;transport;other biological processes" "other cell component" "" "Pf00640" "51454" "ENSG00000144366" "GULP1" "B2RB51; B4DQ40; B8ZZ72; D3DPH1; E9PB86; hsa:51454; Q53PC1; Q53RF3; Q9BVL3; Q9UBP9" "" "" "0" "0" "63.4" "70.0" "71.5" "215.3" "119.7" "72.9" "135.0" "210.3" "417.4" "971.3" "702.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "5" "4" "5" "4" "873" "97.6" "4.60" "698.52" "9.56" "2" "3" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "121.3" "123.8" "180.9" "757.7" "265.7" "114.3" "330.2" "229.8" "280.3" "1557.9" "1510.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "11" "3" "6" "3" "357" "37.5" "5.45" "972.62" "9.54" "3" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "61.1" "44.9" "80.7" "206.8" "112.2" "68.9" "129.6" "66.7" "85.4" "306.2" "207.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "3" "3" "5" "3" "1129" "124.3" "6.61" "968.67" "9.54" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Pathophysiological roles of DUX4 in FSHD1" "3" "0" "161.8" "176.6" "234.3" "715.5" "302.3" "179.9" "397.1" "200.9" "248.4" "754.6" "591.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "10" "3" "6" "3" "368" "42.0" "8.63" "932.57" "9.52" "3" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "177.5" "146.1" "219.8" "756.4" "348.7" "155.6" "335.2" "212.7" "189.6" "559.0" "392.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "4" "1" "4" "1" "307" "35.1" "5.06" "787.06" "9.50" "1" "1" "DNA metabolism;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "Processing of DNA double-strand break ends" "16p11.2 proximal deletion syndrome" "2" "0" "35.2" "26.4" "46.0" "132.2" "73.4" "42.8" "62.0" "33.5" "52.2" "150.8" "105.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61218" "DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Homo sapiens OX=9606 GN=POLR2F PE=1 SV=1" "20" "1" "2" "1" "127" "14.5" "4.22" "" "9.49" "" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01192" "5435" "ENSG00000100142" "POLR2F" "hsa:5435; P41584; P61218; Q6IAY3" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "56" "0" "7.5" "5.8" "6.6" "17.1" "9.5" "7.8" "10.2" "4.5" "16.4" "80.6" "49.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "7" "3" "6" "3" "340" "37.3" "8.73" "995.58" "9.46" "3" "3" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "33.8" "28.1" "38.7" "139.1" "71.9" "42.4" "80.5" "61.7" "151.7" "676.5" "590.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "5" "3" "6" "2" "780" "85.1" "7.99" "832.51" "9.44" "3" "3" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Glycolysis" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis" "5" "1" "132.3" "117.8" "159.3" "467.1" "250.5" "133.6" "247.5" "148.9" "157.9" "647.5" "619.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "17" "3" "6" "3" "243" "27.3" "5.08" "1175.89" "9.43" "3" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "336.1" "287.2" "428.8" "1073.1" "533.9" "262.0" "354.7" "264.3" "301.9" "383.1" "321.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "10" "2" "6" "2" "252" "26.5" "9.36" "1067.30" "9.41" "2" "2" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "" "Pyrimidine metabolism" "1" "0" "91.6" "94.0" "125.6" "418.3" "181.1" "89.1" "179.6" "110.0" "106.0" "272.7" "168.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "9" "2" "3" "2" "459" "51.8" "5.43" "421.29" "9.40" "1" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "Androgen receptor signaling pathway" "6" "0" "23.5" "21.2" "44.6" "157.3" "75.9" "25.0" "38.8" "24.9" "34.0" "65.1" "58.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "8" "4" "7" "3" "577" "63.1" "9.44" "1227.97" "9.38" "4" "3" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "1" "168.3" "144.2" "195.3" "384.0" "242.2" "159.4" "321.4" "154.4" "194.2" "549.2" "378.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "8" "2" "4" "2" "439" "48.5" "7.03" "1190.75" "9.33" "2" "2" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Glutamate and glutamine metabolism" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "4" "0" "98.2" "105.4" "172.5" "855.1" "307.3" "98.0" "103.0" "98.4" "75.9" "193.9" "153.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "4" "3" "6" "3" "955" "108.6" "10.15" "896.79" "9.33" "3" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression" "Interactome of polycomb repressive complex 2 (PRC2)" "3" "0" "108.0" "114.9" "127.5" "325.5" "177.6" "108.3" "187.1" "127.8" "131.8" "355.3" "266.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "9" "3" "6" "3" "386" "43.5" "8.19" "1103.90" "9.33" "3" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "88.5" "82.0" "133.0" "418.7" "207.4" "91.6" "150.4" "106.1" "121.2" "282.1" "599.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "19" "2" "3" "2" "172" "18.6" "9.51" "381.89" "9.31" "1" "2" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "163.0" "120.0" "154.8" "249.1" "181.9" "154.4" "209.7" "118.3" "144.3" "297.6" "207.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "5" "2" "6" "2" "456" "50.2" "6.42" "1010.52" "9.31" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792; ENSG00000284901" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "Ub-specific processing proteases; DNA Damage Recognition in GG-NER; UCH proteinases; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; HATs acetylate histones" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "9" "0" "138.6" "139.8" "178.0" "626.1" "231.7" "110.3" "208.9" "146.2" "148.3" "447.8" "445.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42695" "Condensin-2 complex subunit D3 OS=Homo sapiens OX=9606 GN=NCAPD3 PE=1 SV=2" "2" "2" "6" "2" "1498" "168.8" "7.50" "967.68" "9.30" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12717" "23310" "ENSG00000151503" "NCAPD3" "A6NFS2; hsa:23310; P42695; Q4KMQ9" "Condensation of Prophase Chromosomes" "" "1" "0" "46.5" "37.0" "51.7" "102.7" "60.9" "54.0" "71.9" "38.9" "41.5" "125.5" "103.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "4" "4" "7" "4" "911" "104.8" "5.44" "1544.01" "9.30" "4" "3" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Platelet degranulation ; Nephrin family interactions" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "9" "0" "98.0" "92.0" "152.6" "882.6" "253.4" "67.0" "160.6" "133.1" "122.0" "457.5" "405.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "9" "3" "6" "3" "399" "45.3" "7.75" "1099.30" "9.29" "3" "3" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "167.5" "133.0" "161.3" "350.7" "197.7" "151.1" "281.9" "156.2" "175.1" "474.8" "335.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "11" "2" "6" "2" "282" "31.5" "4.55" "841.54" "9.28" "2" "2" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "20.5" "27.2" "25.2" "132.4" "55.1" "20.4" "26.7" "19.3" "23.6" "35.5" "35.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "7" "2" "4" "2" "421" "46.1" "9.99" "754.49" "9.25" "2" "2" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "228.1" "159.7" "216.8" "321.6" "231.1" "189.2" "278.2" "133.9" "206.3" "313.2" "194.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P39656" "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4" "6" "3" "6" "3" "456" "50.8" "6.55" "1017.74" "9.24" "3" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf03345" "1650" "ENSG00000244038" "DDOST" "B2RDQ4; B4DJE3; B4DLI2; hsa:1650; O43244; P39656; Q5VWA5; Q8NI93; Q9BUI2" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane; Advanced glycosylation endproduct receptor signaling; Asparagine N-linked glycosylation; Maturation of spike protein" "AGE/RAGE pathway; N-glycan biosynthesis" "7" "0" "290.2" "305.8" "413.8" "1584.0" "616.5" "316.4" "567.3" "353.6" "359.0" "1236.8" "1326.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "10" "3" "5" "3" "367" "40.5" "8.90" "792.80" "9.21" "2" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "" "" "0" "0" "174.8" "155.4" "175.5" "423.5" "245.4" "195.9" "341.5" "143.5" "179.2" "468.3" "395.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15084" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5" "3" "3" "6" "2" "1053" "112.9" "6.25" "1042.80" "9.20" "3" "3" "" "cytosol;nucleus" "" "Pf00023, Pf13637" "23243" "ENSG00000206560" "ANKRD28" "B4DES5; hsa:23243; O15084; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "1" "35.2" "32.3" "35.4" "110.6" "59.3" "45.3" "71.4" "39.7" "58.1" "204.0" "192.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82650" "28S ribosomal protein S22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "13" "4" "7" "4" "360" "41.3" "7.90" "1594.28" "9.19" "4" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Primary ovarian insufficiency" "4" "0" "129.7" "147.4" "172.9" "521.0" "229.7" "127.7" "240.8" "160.4" "150.8" "468.2" "340.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "8" "3" "6" "3" "428" "49.0" "5.67" "1194.13" "9.19" "3" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RHOBTB2 GTPase cycle" "" "5" "0" "123.4" "129.3" "194.5" "699.9" "292.6" "119.0" "230.8" "163.6" "167.1" "388.3" "364.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H6S0" "3'-5' RNA helicase YTHDC2 OS=Homo sapiens OX=9606 GN=YTHDC2 PE=1 SV=2" "2" "3" "6" "3" "1430" "160.1" "8.40" "898.06" "9.18" "3" "3" "cell cycle OR cell proliferation;other biological processes" "ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf01424, Pf04146, Pf04408, Pf07717" "64848" "ENSG00000047188" "YTHDC2" "B2RP66; hsa:64848; Q9H6S0" "" "" "0" "0" "58.3" "46.8" "59.1" "192.8" "103.1" "60.8" "130.6" "58.2" "65.4" "254.0" "197.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "3" "2" "4" "2" "986" "111.5" "7.27" "990.44" "9.17" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "Pathogenic Escherichia coli infection" "5" "0" "135.0" "116.4" "173.5" "446.0" "245.9" "123.3" "302.8" "149.6" "186.9" "446.3" "300.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00264" "Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3" "21" "4" "7" "4" "195" "21.7" "4.70" "1362.32" "9.17" "4" "3" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00173" "10857" "ENSG00000101856" "PGRMC1" "B7Z1L3; hsa:10857; O00264; Q9UGJ9" "Neutrophil degranulation" "Primary ovarian insufficiency" "2" "0" "174.8" "192.7" "294.9" "1175.1" "497.3" "199.3" "347.3" "306.8" "323.9" "700.2" "615.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82664" "28S ribosomal protein S10, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2" "16" "2" "4" "2" "201" "23.0" "8.00" "1060.72" "9.15" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "55173" "ENSG00000048544" "MRPS10" "B2RE89; hsa:55173; P82664; Q9H3E5; Q9NVR3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "10.9" "21.4" "20.3" "133.1" "31.1" "15.6" "25.1" "25.9" "21.5" "130.8" "133.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "7" "2" "4" "2" "475" "53.5" "9.09" "1018.91" "9.14" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "5" "0" "77.2" "74.5" "111.3" "454.2" "179.4" "81.4" "160.2" "111.9" "134.3" "473.9" "482.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "16" "2" "4" "2" "172" "19.6" "4.93" "919.86" "9.14" "2" "2" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "77.1" "92.0" "124.8" "534.0" "188.2" "72.3" "136.5" "102.4" "120.4" "436.7" "589.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQA1" "Methylosome protein 50 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "6" "2" "6" "2" "342" "36.7" "5.17" "911.79" "9.14" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "RMTs methylate histone arginines; snRNP Assembly" "" "2" "0" "46.6" "42.7" "64.9" "398.7" "95.1" "26.5" "93.4" "76.1" "54.5" "281.1" "278.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15005" "Signal peptidase complex subunit 2 OS=Homo sapiens OX=9606 GN=SPCS2 PE=1 SV=3" "8" "1" "4" "1" "226" "25.0" "8.47" "955.42" "9.14" "1" "1" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf06703" "9789" "ENSG00000118363" "SPCS2" "hsa:9789; Q15005; Q15507; Q3KQT0; Q641R4; Q6FG65; Q6IRX0; Q6P1P4; Q96HU9" "SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin" "" "4" "0" "34.7" "30.1" "31.8" "96.6" "53.4" "38.7" "48.3" "48.8" "70.8" "175.4" "171.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "5" "4" "5" "4" "754" "84.9" "6.90" "994.55" "9.13" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "29" "0" "65.2" "67.6" "88.0" "263.4" "122.5" "84.8" "144.4" "163.3" "354.1" "2393.0" "3039.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "13" "2" "3" "2" "272" "28.2" "6.28" "311.43" "9.13" "1" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "103.2" "100.4" "126.5" "314.8" "157.1" "102.1" "209.2" "104.6" "111.5" "323.6" "216.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "3" "1" "4" "1" "594" "66.5" "5.59" "1065.89" "9.11" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "" "6" "0" "21.8" "24.0" "30.5" "68.2" "38.3" "29.3" "32.8" "26.1" "21.4" "61.8" "57.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969S3" "Zinc finger protein 622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "13" "6" "7" "6" "477" "54.2" "6.15" "1633.70" "9.11" "4" "3" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "241.9" "226.6" "293.9" "491.9" "337.3" "278.4" "491.7" "214.7" "284.9" "866.8" "584.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "5" "2" "3" "2" "454" "50.1" "8.25" "722.32" "9.09" "1" "2" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "60.2" "68.8" "141.1" "570.1" "213.7" "34.0" "74.5" "75.5" "80.1" "126.5" "117.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P587" "Acylpyruvase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=2" "13" "3" "6" "3" "224" "24.8" "7.39" "1013.25" "9.08" "3" "3" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf01557" "81889" "ENSG00000180185" "FAHD1" "B1AK40; B1AK41; hsa:81889; Q6FIC7; Q6P587; Q96RY1; Q9H0N6" "Citric acid cycle (TCA cycle)" "" "1" "0" "349.3" "331.3" "444.5" "1035.5" "523.3" "300.4" "515.4" "327.6" "442.2" "1050.0" "1319.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "9" "2" "4" "2" "312" "34.8" "8.37" "982.73" "9.04" "2" "2" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "32.4" "36.8" "51.9" "138.6" "50.8" "34.7" "69.7" "50.8" "141.7" "568.5" "834.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00186" "Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2" "5" "3" "6" "3" "592" "67.7" "7.80" "1047.69" "9.04" "3" "3" "cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00995" "6814" "ENSG00000116266" "STXBP3" "A8K269; A8K5K7; hsa:6814; O00186; Q53FW1; Q86YJ3; Q9UPD7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation" "Insulin signaling" "3" "0" "96.6" "77.5" "108.8" "288.0" "141.1" "103.0" "177.0" "91.7" "118.8" "367.7" "407.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "9" "3" "5" "3" "320" "35.3" "8.22" "684.87" "9.02" "2" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14497, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "5" "0" "187.0" "179.8" "251.0" "1015.8" "428.8" "164.2" "275.2" "185.6" "225.5" "892.8" "1161.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96HP0" "Dedicator of cytokinesis protein 6 OS=Homo sapiens OX=9606 GN=DOCK6 PE=1 SV=3" "2" "4" "7" "3" "2047" "229.4" "6.74" "1298.46" "8.99" "4" "3" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "57572" "ENSG00000130158" "DOCK6" "A6H8X5; hsa:57572; Q7Z7P4; Q96HP0; Q9P2F2" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle" "Genetic causes of porto-sinusoidal vascular disease" "4" "0" "85.4" "76.9" "93.4" "211.9" "106.1" "91.9" "165.8" "97.6" "156.5" "421.3" "448.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "7" "2" "4" "2" "446" "49.4" "4.92" "971.04" "8.98" "2" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "66.4" "57.3" "88.8" "309.4" "139.1" "100.8" "219.8" "100.8" "112.9" "463.9" "405.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43143" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "3" "2" "6" "2" "795" "90.9" "7.46" "944.69" "8.93" "2" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "137.6" "116.9" "175.8" "541.0" "195.6" "121.4" "279.1" "125.5" "164.1" "546.0" "398.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "25" "4" "6" "4" "187" "21.0" "7.53" "1544.23" "8.93" "4" "2" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "9" "0" "394.8" "411.5" "684.3" "2945.9" "1026.9" "213.7" "442.1" "414.6" "323.8" "567.3" "554.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01970" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2" "3" "2" "4" "2" "1234" "138.7" "5.90" "986.12" "8.90" "2" "2" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5331" "ENSG00000149782" "PLCB3" "A5PKZ6; G5E960; hsa:5331; Q01970; Q8N1A4" "Synthesis of IP3 and IP4 in the cytosol; G alpha (q) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion" "Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells" "26" "0" "36.4" "27.9" "39.8" "110.0" "43.8" "34.4" "54.0" "42.6" "46.0" "170.4" "235.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z7A4" "PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1" "5" "2" "4" "2" "578" "64.9" "9.35" "807.02" "8.90" "2" "2" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf02205" "54899" "ENSG00000168297" "PXK" "hsa:54899; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q7Z7A4; Q96CA3; Q96R07; Q9NXB8" "" "" "0" "0" "52.8" "54.7" "65.2" "210.0" "101.8" "67.9" "124.0" "81.0" "153.6" "554.2" "604.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "8" "2" "4" "2" "424" "44.3" "8.44" "961.92" "8.88" "2" "2" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "11" "0" "79.3" "67.2" "100.3" "218.4" "124.7" "82.8" "150.5" "75.7" "100.3" "197.7" "156.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "24" "2" "3" "2" "133" "15.2" "5.80" "349.00" "8.84" "1" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "4" "0" "35.4" "33.7" "43.8" "158.1" "56.9" "38.5" "62.8" "45.1" "76.7" "520.6" "513.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06787" "Synaptic functional regulator FMR1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1" "4" "3" "6" "2" "632" "71.1" "7.42" "885.97" "8.81" "3" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16098, Pf17904, Pf18336" "2332" "ENSG00000102081" "FMR1" "A6NNH4; D3DWT0; D3DWT1; D3DWT2; G8JL90; hsa:2332; Q06787; Q16578; Q5PQZ6; Q99054" "" "Ovarian infertility; Serotonin and anxiety; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; Primary ovarian insufficiency" "6" "1" "352.6" "285.5" "429.0" "1253.0" "553.2" "287.8" "696.7" "316.1" "398.4" "1197.7" "770.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "5" "3" "5" "3" "630" "70.9" "8.09" "752.85" "8.80" "2" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "SARS-CoV-1 activates/modulates innate immune responses; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "16" "0" "182.4" "178.6" "190.5" "400.9" "223.3" "167.7" "323.4" "148.2" "204.9" "640.0" "481.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H223" "EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1" "7" "3" "5" "2" "541" "61.1" "6.76" "797.27" "8.80" "2" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30844" "ENSG00000103966" "EHD4" "hsa:30844; Q9H223; Q9HAR1; Q9NZN2" "" "" "0" "0" "40.5" "29.3" "45.2" "137.5" "62.5" "36.5" "69.4" "41.0" "69.3" "325.7" "589.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "31" "3" "4" "3" "128" "14.2" "8.46" "574.97" "8.79" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway; rRNA modification in the nucleus and cytosol" "mRNA processing" "4" "0" "84.6" "59.9" "121.3" "279.8" "155.3" "118.8" "222.1" "118.2" "247.1" "910.4" "754.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6NSI4" "RPA-related protein RADX OS=Homo sapiens OX=9606 GN=RADX PE=1 SV=2" "3" "1" "2" "1" "855" "97.5" "8.41" "" "8.78" "" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf17659" "55086" "ENSG00000147231" "RADX" "H7BY89; hsa:55086; Q4G0L7; Q5JQS1; Q5JRF9; Q6NSI4; Q6PHY5; Q6PII9; Q6PJU8; Q9H7W5; Q9NWA6" "" "" "0" "0" "96.2" "80.5" "98.6" "202.0" "124.6" "109.5" "169.7" "88.3" "103.1" "288.5" "203.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14689" "Disco-interacting protein 2 homolog A OS=Homo sapiens OX=9606 GN=DIP2A PE=1 SV=2" "2" "2" "6" "2" "1571" "170.3" "8.03" "815.43" "8.78" "2" "2" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00501, Pf06464" "23181" "ENSG00000160305" "DIP2A" "A6P4T3; B4E0F0; E7EMA5; hsa:23181; Q14689; Q8IVA3; Q8N4S2; Q8TD89; Q96ML9" "" "Mesodermal commitment pathway" "1" "0" "14.1" "11.1" "16.9" "54.2" "25.4" "15.3" "20.8" "16.4" "30.1" "82.8" "56.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "4" "3" "4" "3" "1024" "114.6" "9.22" "312.28" "8.76" "1" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; hsa:10940; Q15037; Q99575" "tRNA processing in the nucleus" "" "1" "0" "143.1" "117.8" "247.6" "852.0" "368.2" "120.2" "306.7" "115.1" "152.5" "417.0" "311.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "15" "3" "5" "2" "272" "31.2" "11.59" "611.30" "8.72" "2" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "1" "146.3" "151.3" "195.6" "655.0" "274.6" "128.3" "329.3" "213.4" "182.3" "487.6" "365.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "7" "3" "5" "3" "588" "68.0" "7.33" "723.99" "8.71" "2" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "79.4" "74.3" "74.6" "206.4" "99.9" "55.6" "112.5" "68.5" "51.8" "186.3" "207.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7KZ85" "Transcription elongation factor SPT6 OS=Homo sapiens OX=9606 GN=SUPT6H PE=1 SV=2" "2" "3" "4" "3" "1726" "198.9" "4.91" "407.76" "8.70" "1" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00575, Pf14632, Pf14633, Pf14635, Pf14639, Pf14641, Pf17674" "6830" "ENSG00000109111" "SUPT6H" "A7E2B4; hsa:6830; Q15737; Q6GMQ4; Q7KYW9; Q7KZ85; Q7LDK4; Q8N526; Q92775; Q96AH3; Q9BTH9; Q9BTI2" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "38.8" "29.2" "43.7" "145.9" "67.1" "49.1" "87.5" "38.9" "59.8" "135.6" "78.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "4" "3" "5" "2" "876" "98.4" "9.32" "1241.05" "8.70" "3" "2" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "1" "490.0" "361.8" "514.7" "741.9" "585.1" "390.9" "635.8" "333.9" "477.7" "831.0" "611.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "15" "3" "5" "3" "263" "28.3" "8.38" "998.34" "8.67" "3" "2" "transport" "plasma membrane;other membranes" "" "Pf07933" "55707" "ENSG00000157191" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "157.3" "130.9" "158.0" "337.5" "186.5" "152.3" "305.4" "249.7" "422.5" "895.5" "534.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "5" "3" "5" "3" "582" "66.9" "9.55" "733.32" "8.67" "2" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "" "VEGFA-VEGFR2 signaling" "1" "0" "116.6" "79.4" "113.6" "287.7" "148.6" "99.3" "168.1" "70.9" "84.0" "255.4" "163.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "10" "3" "5" "3" "407" "43.4" "8.56" "523.79" "8.66" "2" "3" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "184.6" "180.9" "221.8" "598.3" "289.6" "187.6" "288.0" "214.9" "244.0" "586.7" "489.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00116" "Alkyldihydroxyacetonephosphate synthase, peroxisomal OS=Homo sapiens OX=9606 GN=AGPS PE=1 SV=1" "4" "2" "4" "2" "658" "72.9" "7.34" "970.98" "8.63" "2" "2" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01565, Pf02913" "8540" "ENSG00000018510" "AGPS" "A5D8U9; hsa:8540; O00116; Q2TU35" "Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins" "Triacylglyceride synthesis" "4" "0" "66.8" "62.4" "93.8" "252.0" "121.3" "75.4" "151.7" "81.7" "107.6" "398.2" "379.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UJS0" "Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens OX=9606 GN=SLC25A13 PE=1 SV=2" "3" "1" "4" "1" "675" "74.1" "8.62" "1068.05" "8.62" "1" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00153" "10165" "ENSG00000004864" "SLC25A13" "hsa:10165; O14566; O14575; Q546F9; Q9NZW1; Q9UJS0; Q9UNI7" "Gluconeogenesis; Mitochondrial protein import; Aspartate and asparagine metabolism" "" "3" "0" "26.9" "35.8" "48.9" "129.4" "58.1" "36.6" "76.9" "43.2" "84.4" "225.5" "186.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "10" "2" "4" "2" "286" "32.9" "5.69" "827.76" "8.62" "2" "2" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "Sensory processing of sound by inner hair cells of the cochlea; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "8" "0" "18.7" "19.2" "38.5" "127.4" "55.1" "23.8" "44.6" "32.7" "44.1" "139.9" "99.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "3" "3" "6" "3" "915" "102.6" "5.47" "1039.80" "8.61" "3" "3" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "SUMOylation of transcription cofactors" "Interleukin-1 (IL-1) structural pathway" "2" "0" "188.3" "197.4" "262.5" "1030.8" "402.3" "131.6" "233.4" "215.1" "153.5" "420.8" "321.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96TA2" "ATP-dependent zinc metalloprotease YME1L1 OS=Homo sapiens OX=9606 GN=YME1L1 PE=1 SV=2" "2" "1" "4" "1" "773" "86.4" "8.76" "1002.98" "8.58" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00004, Pf01434, Pf17862" "10730" "ENSG00000136758" "YME1L1" "B4DNM1; D3DRV8; D3DRV9; hsa:10730; Q5T8D9; Q96TA2; Q9H1Q0; Q9UMR9" "Processing of SMDT1" "" "1" "0" "80.9" "97.7" "85.6" "241.5" "94.5" "33.5" "74.8" "42.9" "62.7" "203.6" "157.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15924" "Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3" "2" "4" "6" "4" "2871" "331.6" "6.81" "870.80" "8.57" "3" "3" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00681, Pf17902, Pf18373" "1832" "ENSG00000096696" "DSP" "B2RTT2; D7RX09; hsa:1832; O75993; P15924; Q14189; Q9UHN4" "Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer" "9" "0" "1054.7" "848.4" "502.9" "748.3" "429.5" "211.5" "407.7" "204.7" "281.6" "467.1" "295.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "4" "3" "5" "3" "1264" "140.4" "7.59" "1434.69" "8.57" "3" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Cytosolic tRNA aminoacylation" "Amino acid metabolism" "2" "0" "228.4" "197.1" "281.1" "782.9" "340.6" "220.9" "309.7" "193.8" "241.3" "476.3" "387.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "7" "2" "4" "2" "344" "39.4" "7.68" "828.76" "8.56" "2" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "" "Primary ovarian insufficiency" "1" "0" "16.0" "21.0" "28.0" "132.4" "45.9" "14.0" "38.7" "24.4" "36.4" "105.8" "245.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5D862" "Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1" "2" "3" "6" "3" "2391" "247.9" "8.31" "556.67" "8.56" "2" "3" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other cell component" "other molecular function" "Pf01023" "388698" "ENSG00000143520" "FLG2" "hsa:388698; Q5D862; Q9H4U1" "Neutrophil degranulation" "" "1" "0" "452.6" "270.2" "149.6" "67.3" "32.9" "36.2" "102.8" "46.8" "66.4" "144.9" "104.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "2" "3" "7" "3" "734" "82.2" "8.37" "1254.56" "8.56" "3" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 10q11.21q11.23 copy number variation syndrome" "11" "0" "78.7" "84.7" "112.3" "577.5" "193.1" "91.0" "163.2" "131.9" "152.4" "587.5" "680.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HB21" "Pleckstrin homology domain-containing family A member 1 OS=Homo sapiens OX=9606 GN=PLEKHA1 PE=1 SV=2" "9" "3" "5" "3" "404" "45.5" "8.56" "750.01" "8.55" "2" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00169" "59338" "ENSG00000107679" "PLEKHA1" "B3KQ55; D3DRE2; hsa:59338; Q9BVK0; Q9HB21" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "10.0" "9.2" "21.4" "55.7" "25.0" "18.4" "60.4" "52.6" "139.7" "572.2" "634.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WUR7" "UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2" "25" "3" "5" "3" "153" "16.3" "9.83" "1324.62" "8.52" "3" "2" "" "other cell component" "" "Pf02594" "123207" "ENSG00000169609" "C15orf40" "A6NIC9; B2R5E7; F5GX92; F8WD31; G5EA00; hsa:123207; Q8WUR7" "" "" "0" "0" "137.8" "110.3" "174.1" "401.5" "215.6" "133.3" "249.3" "125.9" "248.1" "762.2" "665.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "8" "2" "4" "2" "309" "34.5" "8.98" "911.90" "8.50" "2" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "172.4" "103.2" "161.2" "474.4" "266.5" "119.1" "207.1" "99.7" "160.4" "283.3" "179.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "4" "3" "6" "3" "1023" "115.9" "6.86" "995.21" "8.49" "3" "3" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "8" "0" "102.9" "77.9" "132.2" "274.8" "165.3" "96.2" "134.7" "105.4" "140.4" "189.9" "139.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "3" "3" "5" "3" "1134" "123.7" "5.66" "589.35" "8.49" "2" "3" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Neutrophil degranulation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Platelet degranulation ; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "18" "0" "60.8" "67.2" "79.8" "437.7" "156.4" "39.2" "82.7" "62.2" "60.7" "181.4" "133.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N9I9" "Probable E3 ubiquitin-protein ligase DTX3 OS=Homo sapiens OX=9606 GN=DTX3 PE=1 SV=2" "9" "2" "3" "2" "347" "38.0" "8.73" "575.40" "8.44" "1" "2" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "other molecular function" "Pf13923, Pf18102" "196403" "ENSG00000178498" "DTX3" "hsa:196403; Q53ZZ2; Q8N9I9; Q8NAU6; Q8NDS8" "" "Notch signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "9" "3" "5" "3" "426" "48.6" "5.31" "1085.23" "8.41" "3" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "" "VEGFA-VEGFR2 signaling" "1" "0" "160.0" "145.1" "164.8" "447.7" "230.3" "171.8" "295.1" "144.4" "178.6" "408.8" "281.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "6" "2" "3" "2" "591" "64.0" "9.73" "241.23" "8.40" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "CDC42 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "24" "0" "187.4" "218.1" "164.4" "326.1" "177.5" "149.7" "258.7" "124.6" "143.8" "426.8" "312.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60613" "Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4" "10" "1" "4" "1" "165" "18.1" "5.03" "873.51" "8.39" "1" "1" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf08806" "9403" "ENSG00000183291" "SELENOF" "A0A0B4J1S4; hsa:9403; O60613; Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01" "" "Selenium metabolism / selenoproteins; Selenium micronutrient network" "2" "0" "37.9" "28.8" "46.6" "104.6" "60.2" "39.3" "65.5" "35.5" "45.9" "140.6" "100.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "8" "3" "5" "3" "504" "57.5" "6.15" "1207.23" "8.36" "3" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181, Pf13432" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Neutrophil degranulation; Viral mRNA Translation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "6" "0" "88.5" "87.1" "119.6" "309.8" "145.9" "94.3" "175.4" "105.4" "178.0" "596.2" "552.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "1" "3" "7" "2" "2603" "274.1" "6.52" "1377.94" "8.34" "3" "2" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "1" "93.1" "73.1" "81.1" "192.3" "95.2" "86.3" "157.0" "73.1" "140.5" "473.2" "299.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60716" "Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1" "3" "2" "4" "2" "968" "108.1" "6.23" "776.90" "8.33" "2" "2" "cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00514" "1500" "ENSG00000198561" "CTNND1" "A8K939; hsa:1500; O15088; O60713; O60714; O60715; O60716; O60935; Q6DHZ7; Q6RBX8; Q9UP71; Q9UP72; Q9UP73" "VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency" "8" "0" "182.6" "131.9" "222.8" "342.3" "277.9" "239.4" "294.1" "108.5" "174.9" "402.5" "401.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZI7" "Upstream-binding protein 1 OS=Homo sapiens OX=9606 GN=UBP1 PE=1 SV=1" "5" "2" "4" "1" "540" "60.5" "6.35" "810.35" "8.32" "2" "2" "RNA metabolism OR transcription;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7342" "ENSG00000153560" "UBP1" "hsa:7342; Q68CT0; Q86Y57; Q9H8V0; Q9NZI7; Q9UD76; Q9UD78" "" "" "0" "0" "40.2" "30.9" "51.3" "126.9" "61.0" "38.6" "78.2" "45.5" "80.6" "523.4" "426.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "6" "2" "4" "2" "518" "58.2" "8.13" "841.50" "8.32" "2" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Mitochondrial tRNA aminoacylation" "" "1" "0" "34.3" "38.4" "40.4" "110.7" "58.9" "31.6" "67.3" "34.7" "40.9" "150.1" "144.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "3" "2" "4" "2" "1170" "129.9" "6.93" "1013.91" "8.31" "2" "2" "" "" "" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "151.0" "142.5" "183.3" "266.8" "196.8" "158.4" "231.2" "137.5" "175.7" "319.3" "215.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "6" "2" "4" "2" "464" "49.2" "9.64" "887.24" "8.31" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "101.0" "107.4" "152.0" "488.3" "210.3" "125.0" "232.7" "131.2" "143.5" "495.6" "406.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "21" "3" "5" "3" "209" "23.2" "5.38" "622.16" "8.27" "1" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex" "Ciliary landscape; 2q37 copy number variation syndrome" "6" "0" "51.1" "53.0" "66.0" "217.7" "138.2" "82.6" "311.6" "181.6" "201.2" "840.0" "1106.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N5N7" "39S ribosomal protein L50, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "25" "2" "4" "2" "158" "18.3" "7.88" "740.09" "8.26" "2" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "6.5" "10.8" "17.0" "37.0" "15.5" "8.3" "24.6" "11.4" "6.9" "61.6" "49.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23378" "Glycine dehydrogenase (decarboxylating), mitochondrial OS=Homo sapiens OX=9606 GN=GLDC PE=1 SV=2" "3" "2" "4" "2" "1020" "112.7" "7.11" "826.17" "8.26" "2" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01212, Pf02347" "2731" "ENSG00000178445" "GLDC" "hsa:2731; P23378; Q2M2F8" "Glycine degradation" "" "1" "0" "55.8" "51.1" "66.2" "181.3" "83.6" "53.7" "101.9" "65.6" "144.4" "684.9" "821.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q3SYG4" "Protein PTHB1 OS=Homo sapiens OX=9606 GN=BBS9 PE=1 SV=1" "3" "2" "4" "2" "887" "99.2" "5.55" "846.44" "8.26" "2" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf14727, Pf14728" "27241" "ENSG00000122507" "BBS9" "E9PDC9; hsa:27241; P78514; Q3SYG4; Q7KYS6; Q7KYS7; Q8N570; Q99844; Q99854; Q9Y699; Q9Y6A0" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "32.6" "17.7" "26.4" "72.2" "40.4" "27.7" "48.8" "43.0" "89.7" "302.8" "217.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "4" "2" "3" "2" "963" "109.9" "5.57" "336.62" "8.26" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "36.4" "32.6" "55.8" "201.5" "90.4" "40.0" "91.6" "48.3" "58.9" "156.7" "93.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P80723" "Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2" "22" "3" "6" "3" "227" "22.7" "4.63" "1227.61" "8.25" "2" "1" "RNA metabolism OR transcription;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05466" "10409" "ENSG00000176788" "BASP1" "B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5" "RHOF GTPase cycle" "" "1" "0" "73.5" "52.3" "70.6" "92.9" "68.5" "48.5" "71.4" "29.7" "55.6" "70.6" "39.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "7" "2" "4" "2" "391" "45.1" "7.74" "761.64" "8.21" "2" "2" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "21" "0" "70.3" "80.1" "132.8" "442.1" "204.6" "99.9" "193.6" "119.5" "125.9" "560.3" "568.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "5" "2" "4" "2" "617" "68.3" "5.52" "980.00" "8.19" "2" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "46.8" "46.1" "61.1" "213.8" "87.2" "60.3" "71.5" "53.9" "57.6" "123.4" "125.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14795" "Protein unc-13 homolog B OS=Homo sapiens OX=9606 GN=UNC13B PE=1 SV=2" "2" "2" "4" "2" "1591" "180.6" "5.99" "816.21" "8.15" "2" "2" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00130, Pf00168, Pf06292" "10497" "ENSG00000198722" "UNC13B" "hsa:10497; O14795; Q2NKJ5; Q5VYM8" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle" "Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport" "8" "0" "9.6" "11.0" "15.4" "46.3" "22.4" "10.8" "24.9" "28.7" "81.5" "650.3" "519.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96F85" "CB1 cannabinoid receptor-interacting protein 1 OS=Homo sapiens OX=9606 GN=CNRIP1 PE=1 SV=1" "21" "2" "3" "2" "164" "18.6" "7.94" "245.55" "8.14" "1" "2" "other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf15043" "25927" "ENSG00000119865" "CNRIP1" "B2R4D0; hsa:25927; Q49AN4; Q96F85; Q9UFZ0" "" "" "0" "0" "26.8" "23.2" "30.7" "72.2" "43.4" "26.9" "89.9" "97.0" "233.8" "730.5" "572.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "5" "3" "6" "3" "579" "62.3" "8.79" "1282.34" "8.14" "3" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "0" "383.2" "354.5" "390.4" "806.7" "451.2" "350.1" "755.7" "318.1" "452.0" "1246.0" "1015.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14923" "Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3" "5" "3" "6" "3" "745" "81.7" "6.14" "1182.79" "8.12" "3" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00514" "3728" "ENSG00000173801" "JUP" "hsa:3728; P14923; Q15093; Q15151; Q7L3S5; Q86W21; Q9BWC4; Q9HCX9" "Neutrophil degranulation; Formation of the cornified envelope; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions; RHOH GTPase cycle" "Arrhythmogenic right ventricular cardiomyopathy; Corticotropin-releasing hormone signaling pathway; Ectoderm differentiation; Ectoderm differentiation; Epithelial to mesenchymal transition in colorectal cancer; Opioid receptor pathways" "21" "0" "222.3" "190.2" "85.7" "82.7" "41.2" "14.8" "35.7" "30.5" "34.3" "82.9" "61.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "2" "2" "4" "2" "1390" "155.5" "8.48" "1009.19" "8.10" "2" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "9" "0" "71.6" "63.3" "89.5" "231.7" "107.4" "71.5" "121.6" "66.0" "78.2" "252.0" "215.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "11" "3" "6" "3" "219" "24.6" "4.83" "936.69" "8.07" "3" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "Ferroptosis" "3" "0" "113.7" "90.1" "143.3" "518.1" "242.7" "93.7" "219.1" "159.9" "201.9" "572.0" "446.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42356" "Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4" "2" "2" "4" "2" "2102" "236.7" "7.06" "630.77" "8.07" "2" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf19274" "5297" "ENSG00000241973" "PI4KA" "hsa:5297; P42356; Q7Z625; Q9UPG2" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane" "Ectoderm differentiation; 22q11.2 copy number variation syndrome" "4" "0" "5.1" "6.9" "5.2" "48.5" "12.2" "8.6" "9.1" "9.9" "14.3" "25.3" "28.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15831" "Serine/threonine-protein kinase STK11 OS=Homo sapiens OX=9606 GN=STK11 PE=1 SV=1" "7" "2" "4" "2" "433" "48.6" "7.43" "733.42" "8.07" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "6794" "ENSG00000118046" "STK11" "B2RBX7; E7EW76; hsa:6794; Q15831" "Regulation of TP53 Activity through Phosphorylation; Energy dependent regulation of mTOR by LKB1-AMPK; FOXO-mediated transcription of cell death genes; AMPK inhibits chREBP transcriptional activation activity" "AMP-activated protein kinase signaling; mir-124 predicted interactions with cell cycle and differentiation ; ATM signaling in development and disease ; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Female steroid hormones in cardiomyocyte energy metabolism" "12" "0" "49.3" "44.4" "51.4" "128.3" "65.8" "47.7" "83.3" "70.4" "146.6" "732.0" "604.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "9" "3" "10" "2" "305" "30.8" "9.29" "2055.49" "8.06" "3" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "194.5" "153.8" "178.6" "407.0" "211.0" "139.6" "276.2" "130.1" "148.0" "425.0" "239.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94905" "Erlin-2 OS=Homo sapiens OX=9606 GN=ERLIN2 PE=1 SV=1" "7" "3" "5" "3" "339" "37.8" "5.62" "596.44" "8.05" "2" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01145" "11160" "ENSG00000147475" "ERLIN2" "A0JLQ1; A8K5S9; B4DM38; D3DSW0; hsa:11160; O94905; Q6NW21; Q86VS6; Q86W49" "ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions" "" "4" "0" "306.8" "299.1" "399.0" "1458.4" "561.3" "264.5" "573.0" "346.0" "397.9" "1226.4" "968.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "5" "2" "3" "2" "584" "64.7" "7.65" "322.10" "8.01" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "55.1" "56.7" "60.3" "140.5" "89.6" "55.4" "105.8" "65.1" "70.5" "273.9" "322.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82673" "28S ribosomal protein S35, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "5" "2" "6" "2" "323" "36.8" "8.24" "929.32" "8.00" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "120.2" "101.3" "143.9" "365.7" "197.8" "127.7" "182.4" "106.9" "145.6" "314.6" "202.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P43155" "Carnitine O-acetyltransferase OS=Homo sapiens OX=9606 GN=CRAT PE=1 SV=5" "5" "3" "6" "3" "626" "70.8" "8.44" "841.11" "8.00" "3" "3" "other metabolic processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00755" "1384" "ENSG00000095321" "CRAT" "P43155; Q5T952; Q9BW16" "Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA" "Fatty acid beta-oxidation" "3" "0" "104.8" "87.1" "108.4" "258.5" "136.8" "105.7" "180.1" "108.8" "160.5" "721.3" "828.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "5" "2" "3" "2" "619" "70.1" "8.51" "528.93" "8.00" "1" "2" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "mRNA processing" "5" "0" "114.5" "119.4" "126.4" "227.0" "150.0" "132.5" "171.6" "102.0" "120.2" "244.1" "145.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "15" "3" "6" "3" "177" "19.2" "8.07" "1000.12" "7.99" "3" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "" "2" "0" "194.3" "178.4" "250.8" "826.3" "376.9" "179.1" "354.8" "245.1" "368.0" "1401.2" "1313.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "4" "2" "6" "2" "476" "54.4" "8.25" "911.80" "7.96" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "18" "0" "136.4" "120.5" "196.7" "589.4" "286.6" "178.7" "253.8" "207.3" "410.3" "977.3" "898.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "18" "2" "3" "2" "176" "18.4" "9.44" "231.99" "7.95" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "148.2" "105.3" "171.3" "294.1" "198.6" "118.8" "169.9" "90.9" "136.0" "267.9" "212.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52815" "39S ribosomal protein L12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "12" "3" "5" "3" "198" "21.3" "8.87" "1212.19" "7.94" "3" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "102.2" "115.7" "154.1" "963.9" "271.7" "118.3" "287.2" "131.5" "186.7" "782.7" "596.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "3" "3" "4" "3" "1074" "116.9" "9.04" "649.69" "7.94" "2" "2" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "" "Exercise-induced circadian regulation" "1" "0" "413.2" "287.1" "424.6" "636.2" "469.7" "311.7" "608.1" "265.1" "468.9" "811.3" "439.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04908" "Histone H2A type 1-B/E OS=Homo sapiens OX=9606 GN=H2AC4 PE=1 SV=2" "22" "2" "6" "2" "130" "14.1" "11.05" "947.12" "7.93" "2" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3012; 8335" "ENSG00000277075; ENSG00000278463" "H2AC4; H2AC8" "hsa:3012; hsa:8335; P04908; P28001; Q76P63" "HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Transcriptional regulation by small RNAs; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Metalloprotease DUBs; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "Proteasome degradation" "42" "0" "277.9" "254.4" "277.0" "679.1" "341.7" "204.0" "423.2" "268.7" "239.7" "602.2" "411.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96MX6" "WD repeat-containing protein 92 OS=Homo sapiens OX=9606 GN=WDR92 PE=1 SV=1" "9" "3" "5" "3" "357" "39.7" "8.09" "1068.46" "7.93" "3" "2" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "119.0" "99.3" "130.7" "290.5" "158.1" "121.9" "217.4" "114.7" "152.3" "708.8" "794.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "5" "2" "4" "2" "607" "68.6" "5.80" "800.82" "7.93" "2" "2" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "58.6" "47.1" "57.5" "108.9" "74.7" "44.7" "69.3" "45.2" "52.3" "86.3" "71.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "3" "2" "4" "2" "1029" "118.2" "8.47" "841.61" "7.92" "2" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "mRNA Splicing - Major Pathway" "" "1" "0" "52.2" "38.4" "59.8" "103.1" "78.8" "54.3" "78.8" "28.2" "49.5" "76.9" "46.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T5C0" "Syntaxin-binding protein 5 OS=Homo sapiens OX=9606 GN=STXBP5 PE=1 SV=1" "3" "2" "3" "2" "1151" "127.5" "7.28" "321.05" "7.92" "1" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00400, Pf08366, Pf08596" "134957" "ENSG00000164506" "STXBP5" "hsa:134957; Q14DF3; Q5T5C0; Q5T5C1; Q5T5C2; Q8NBG8; Q96NG9" "" "" "0" "0" "10.2" "7.8" "6.3" "16.8" "9.4" "9.9" "17.7" "20.9" "37.7" "205.2" "229.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "22" "3" "5" "3" "178" "18.9" "7.49" "1494.97" "7.91" "3" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "197.6" "158.8" "230.2" "1056.0" "353.0" "102.9" "195.9" "148.0" "176.6" "301.5" "234.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "8" "3" "5" "3" "432" "47.7" "6.34" "1068.77" "7.91" "3" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications" "10" "0" "185.4" "223.1" "358.3" "2325.5" "645.2" "110.2" "195.6" "263.0" "194.6" "397.1" "418.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "10" "3" "6" "3" "326" "36.1" "9.17" "1119.52" "7.90" "3" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "HuR (ELAVL1) binds and stabilizes mRNA" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "10" "0" "299.5" "261.6" "363.3" "1097.9" "481.2" "214.8" "484.1" "261.8" "289.3" "968.7" "736.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "2" "2" "4" "1" "780" "85.0" "7.50" "670.51" "7.90" "2" "2" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Neutrophil degranulation; Glycolysis" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis" "8" "0" "51.9" "51.5" "65.5" "208.3" "87.7" "41.9" "77.4" "70.4" "56.7" "193.5" "185.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T653" "39S ribosomal protein L2, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2" "9" "2" "4" "2" "305" "33.3" "11.30" "964.27" "7.89" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00181, Pf03947" "51069" "ENSG00000112651" "MRPL2" "B2RC56; hsa:51069; Q5T653; Q8WUL1; Q96Q56; Q9Y311" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "14.4" "13.6" "13.7" "58.6" "25.4" "11.0" "22.9" "12.7" "13.8" "30.8" "36.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UJV3" "Probable E3 ubiquitin-protein ligase MID2 OS=Homo sapiens OX=9606 GN=MID2 PE=1 SV=3" "3" "2" "6" "1" "735" "83.2" "7.39" "1047.43" "7.87" "2" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00622, Pf00643, Pf13445, Pf18568" "11043" "ENSG00000080561" "MID2" "A6NEL8; A6PVI5; hsa:11043; Q5JYF5; Q8WWK1; Q9UJR9; Q9UJV3" "" "" "0" "0" "5.7" "6.9" "8.3" "7.5" "7.8" "7.9" "12.3" "10.2" "13.6" "92.5" "82.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96GA3" "Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1" "6" "2" "4" "2" "475" "54.8" "4.91" "840.56" "7.86" "2" "2" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04180" "84946" "ENSG00000135521" "LTV1" "hsa:84946; Q96GA3; Q96JX8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "82.9" "58.0" "96.8" "254.7" "112.2" "78.9" "134.3" "71.1" "75.8" "197.3" "145.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRJ6" "Uncharacterized protein C7orf50 OS=Homo sapiens OX=9606 GN=C7orf50 PE=1 SV=1" "11" "2" "4" "2" "194" "22.1" "9.64" "818.83" "7.84" "2" "2" "" "" "" "Pf10180" "84310" "ENSG00000146540" "C7orf50" "hsa:84310; Q9BRJ6" "" "" "0" "0" "121.8" "84.8" "121.2" "252.5" "161.2" "111.5" "215.6" "68.1" "127.7" "343.7" "170.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYB9" "Abl interactor 2 OS=Homo sapiens OX=9606 GN=ABI2 PE=1 SV=1" "4" "2" "4" "1" "513" "55.6" "6.16" "743.81" "7.84" "2" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07815, Pf14604" "10152" "ENSG00000138443" "ABI2" "B4DSN1; hsa:10152; Q13147; Q13249; Q13801; Q9BV70; Q9NYB9" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "Regulation of actin cytoskeleton" "8" "0" "60.4" "65.9" "54.9" "94.3" "70.7" "68.7" "113.1" "72.0" "102.3" "320.1" "335.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9GZS3" "WD repeat-containing protein 61 OS=Homo sapiens OX=9606 GN=WDR61 PE=1 SV=1" "4" "1" "4" "1" "305" "33.6" "5.47" "917.74" "7.83" "1" "1" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; mRNA decay by 3' to 5' exoribonuclease" "" "5" "0" "71.3" "54.0" "70.3" "175.4" "91.6" "72.1" "133.4" "58.0" "90.2" "313.8" "209.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "2" "2" "4" "2" "1001" "113.6" "6.29" "921.50" "7.82" "2" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "E3 ubiquitin ligases ubiquitinate target proteins" "ATM signaling in development and disease" "2" "0" "60.9" "58.7" "79.7" "230.6" "113.0" "59.1" "112.2" "69.5" "74.8" "345.5" "586.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "2" "2" "4" "2" "821" "92.8" "5.41" "881.07" "7.81" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication; 10q11.21q11.23 copy number variation syndrome" "12" "0" "264.0" "288.5" "360.9" "1546.0" "542.4" "227.7" "348.1" "287.8" "255.6" "658.1" "629.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "6" "1" "4" "1" "293" "34.2" "9.88" "796.14" "7.81" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "23.9" "19.5" "29.7" "70.0" "27.4" "21.0" "51.5" "24.2" "27.5" "122.0" "112.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00165" "HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2" "12" "3" "5" "3" "279" "31.6" "4.92" "646.07" "7.74" "2" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "" "10456" "ENSG00000143575" "HAX1" "A8W4W9; A8W4X0; B4DUJ7; hsa:10456; O00165; Q5VYD5; Q5VYD7; Q96AU4; Q9BS80" "" "Primary ovarian insufficiency" "1" "0" "73.2" "67.1" "99.5" "261.1" "131.4" "92.1" "135.4" "90.0" "112.5" "276.6" "221.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "11" "2" "4" "2" "258" "29.2" "9.01" "870.35" "7.74" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "121.7" "102.2" "147.8" "298.2" "178.8" "114.0" "192.7" "110.3" "197.0" "840.6" "771.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06737" "Glycogen phosphorylase, liver form OS=Homo sapiens OX=9606 GN=PYGL PE=1 SV=4" "3" "2" "4" "2" "847" "97.1" "7.17" "752.66" "7.72" "2" "2" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00343" "5836" "ENSG00000100504" "PYGL" "A6NDQ4; B4DUB7; F5H816; hsa:5836; O60567; O60752; O60913; P06737; Q501V9; Q641R5; Q96G82" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "TNF-alpha signaling pathway; Glycogen synthesis and degradation; Disorders of galactose metabolism" "5" "0" "46.7" "63.2" "90.0" "498.1" "161.6" "36.0" "96.6" "79.1" "76.5" "251.9" "275.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "9" "4" "6" "4" "584" "65.4" "7.61" "801.70" "7.68" "3" "3" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "Citric acid cycle (TCA cycle)" "TCA cycle in senescence" "2" "0" "242.9" "226.7" "294.0" "929.3" "364.9" "227.2" "348.8" "214.1" "232.3" "1180.2" "1395.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "3" "3" "5" "3" "1337" "150.7" "7.91" "511.24" "7.66" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome" "5" "0" "73.5" "74.1" "86.0" "282.9" "116.4" "68.1" "135.7" "84.7" "102.1" "434.1" "447.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "22" "3" "7" "3" "129" "14.6" "8.88" "1218.09" "7.65" "3" "2" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "146.0" "139.9" "217.6" "1187.4" "333.8" "75.5" "274.5" "172.7" "179.8" "778.8" "756.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49773" "Histidine triad nucleotide-binding protein 1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "11" "1" "4" "1" "126" "13.8" "6.95" "807.93" "7.61" "1" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "58.1" "76.3" "107.9" "835.6" "203.4" "15.4" "96.0" "144.2" "88.3" "190.9" "261.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "17" "3" "5" "3" "221" "25.5" "11.85" "508.86" "7.59" "2" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "166.7" "157.7" "209.3" "600.0" "269.4" "153.8" "313.6" "193.8" "157.7" "438.5" "325.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "15" "3" "5" "3" "264" "30.2" "7.50" "1476.62" "7.59" "3" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619; ENSG00000285387" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "RHOG GTPase cycle; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "92.6" "101.7" "132.0" "520.0" "190.1" "97.3" "186.1" "127.9" "151.5" "489.3" "549.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "5" "3" "6" "2" "572" "61.6" "8.38" "834.57" "7.55" "3" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "31.6" "32.1" "53.4" "327.1" "93.4" "14.1" "61.8" "48.0" "41.7" "180.0" "168.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "8" "2" "4" "2" "490" "54.9" "10.13" "1009.53" "7.50" "2" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "43.9" "34.8" "46.0" "95.3" "51.5" "42.2" "76.3" "43.3" "42.9" "98.0" "66.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q1L5Z9" "LON peptidase N-terminal domain and RING finger protein 2 OS=Homo sapiens OX=9606 GN=LONRF2 PE=2 SV=3" "4" "2" "3" "2" "754" "83.6" "5.90" "573.24" "7.49" "1" "2" "" "other cell component" "other molecular function" "Pf02190, Pf13923" "164832" "ENSG00000170500" "LONRF2" "B9A006; hsa:164832; Q1L5Z9; Q6ZSR4" "" "" "0" "0" "15.2" "14.5" "22.9" "64.1" "31.2" "14.1" "34.6" "18.5" "28.6" "186.8" "368.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "6" "2" "4" "1" "371" "43.7" "9.92" "726.97" "7.48" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "" "VEGFA-VEGFR2 signaling" "1" "0" "52.0" "43.8" "66.6" "209.0" "103.0" "58.0" "94.9" "64.6" "66.4" "171.2" "149.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "17" "2" "4" "2" "150" "16.8" "6.79" "768.01" "7.46" "2" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Arachidonate epoxygenase / epoxide hydrolase" "7" "0" "72.7" "63.3" "94.9" "384.4" "123.3" "59.5" "147.6" "84.0" "99.5" "266.4" "225.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96GC5" "39S ribosomal protein L48, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL48 PE=1 SV=2" "5" "1" "4" "1" "212" "23.9" "8.98" "916.08" "7.45" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "51642" "ENSG00000175581" "MRPL48" "B4DN34; hsa:51642; Q49AK7; Q4U2Q4; Q96GC5; Q9P091; Q9Y5J0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "142.5" "127.7" "173.4" "429.7" "211.3" "133.9" "233.9" "147.2" "141.3" "448.8" "435.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "10" "1" "4" "1" "157" "17.2" "8.91" "745.00" "7.44" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "169.8" "170.6" "127.6" "277.2" "140.8" "129.6" "234.6" "208.7" "163.1" "419.7" "254.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "3" "2" "4" "2" "904" "101.8" "5.52" "820.29" "7.44" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome" "12" "0" "21.3" "17.6" "31.8" "102.4" "41.9" "18.3" "32.5" "33.1" "27.6" "61.8" "48.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "23" "2" "4" "2" "97" "10.9" "9.41" "856.48" "7.42" "2" "2" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "146.9" "102.5" "165.1" "484.4" "234.9" "128.9" "278.5" "113.2" "146.2" "340.4" "200.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P21796" "Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2" "10" "3" "5" "3" "283" "30.8" "8.54" "562.49" "7.42" "2" "3" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01459" "7416" "ENSG00000213585" "VDAC1" "B3KVK4; D3DQ93; hsa:7416; P21796; Q5FVE7; Q9UIQ5; Q9UPL0" "PINK1-PRKN Mediated Mitophagy; Ub-specific processing proteases; Pyruvate metabolism; Mitochondrial protein import; Mitochondrial calcium ion transport" "Alzheimer's disease and miRNA effects; Alzheimer's disease; Arsenic metabolism and reactive oxygen species generation; Cholesterol metabolism; Fatty Acids and Lipoproteins Transport in Hepatocytes" "10" "0" "149.4" "138.1" "187.2" "830.4" "296.4" "114.6" "214.9" "157.2" "173.9" "620.6" "781.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "10" "5" "7" "4" "440" "49.2" "6.21" "1789.84" "7.42" "5" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "261.5" "256.5" "336.6" "835.4" "430.6" "291.2" "449.4" "232.1" "308.3" "817.0" "590.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "10" "2" "4" "2" "217" "25.1" "6.15" "837.53" "7.42" "2" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; mTORC1-mediated signalling" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "30" "0" "119.5" "132.6" "157.9" "512.4" "222.9" "115.7" "237.0" "150.5" "205.3" "703.3" "905.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "4" "3" "5" "3" "1030" "115.2" "5.40" "609.95" "7.40" "2" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "8" "0" "76.8" "57.7" "94.8" "228.7" "133.4" "96.3" "124.5" "61.4" "86.2" "193.4" "148.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "13" "2" "4" "1" "201" "22.2" "5.73" "791.79" "7.38" "2" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "COPII-mediated vesicle transport; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "0" "94.3" "75.7" "170.6" "908.9" "325.6" "110.6" "166.5" "143.3" "154.7" "558.9" "260.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "4" "2" "3" "2" "747" "85.1" "4.91" "305.90" "7.37" "1" "2" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "74.6" "85.5" "107.8" "349.4" "140.6" "86.4" "182.9" "96.2" "81.4" "424.4" "194.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "10" "2" "4" "2" "229" "25.2" "4.64" "886.49" "7.36" "2" "2" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "Ebola virus infection in host; Fragile X syndrome" "10" "0" "192.5" "163.5" "209.3" "607.4" "289.6" "151.5" "265.6" "149.0" "161.5" "354.3" "232.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "20" "2" "5" "2" "90" "9.4" "9.99" "1115.36" "7.33" "2" "1" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "53.0" "32.5" "30.9" "81.7" "41.8" "24.6" "52.3" "17.3" "61.4" "254.4" "256.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VT25" "Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1" "3" "3" "5" "3" "1732" "197.2" "6.58" "1084.84" "7.31" "3" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00780, Pf08826, Pf15796" "8476" "ENSG00000143776" "CDC42BPA" "hsa:8476; O75039; Q59GZ1; Q5H9N9; Q5T797; Q5VT25; Q5VT26; Q5VT27; Q86XX2; Q86XX3; Q99646" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "Male infertility" "5" "0" "5.1" "2.9" "2.4" "10.6" "6.4" "6.0" "6.5" "6.5" "11.8" "48.9" "24.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "4" "2" "4" "2" "707" "78.5" "4.87" "803.15" "7.30" "2" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "61.5" "54.0" "87.7" "226.7" "105.2" "56.6" "157.6" "81.6" "65.1" "202.8" "149.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "7" "2" "2" "2" "467" "52.3" "6.58" "" "7.28" "" "2" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "Ub-specific processing proteases; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; A network map of Macrophage-stimulating protein (MSP) signaling; TGF-beta receptor signaling" "47" "0" "63.4" "52.9" "77.7" "139.8" "93.9" "76.1" "162.0" "66.3" "104.6" "461.9" "402.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "12" "3" "5" "3" "201" "22.8" "7.02" "852.37" "7.25" "3" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "464.4" "373.0" "551.6" "1266.2" "760.2" "449.9" "746.6" "338.9" "442.3" "908.6" "722.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "4" "1" "4" "1" "469" "51.7" "5.21" "1051.84" "7.23" "1" "1" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Translation inhibitors in chronically activated PDGFRA cells; A network map of Macrophage-stimulating protein (MSP) signaling; Interferon type I signaling pathways" "4" "0" "44.2" "40.8" "46.0" "88.2" "53.6" "44.1" "72.7" "30.1" "33.5" "74.4" "37.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "8" "2" "4" "1" "270" "31.8" "6.55" "607.52" "7.22" "2" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "" "2" "0" "6.0" "6.3" "9.4" "16.1" "10.3" "5.7" "9.2" "19.9" "15.0" "54.8" "55.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "4" "2" "3" "2" "793" "91.0" "7.18" "275.94" "7.20" "1" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "12.6" "13.9" "17.6" "39.9" "26.2" "21.5" "37.0" "18.1" "25.3" "77.1" "76.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "5" "2" "3" "2" "593" "68.0" "7.30" "451.95" "7.18" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "PIP3 activates AKT signaling; GPVI-mediated activation cascade; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Platelet sensitization by LDL; CTLA4 inhibitory signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interleukin-3, Interleukin-5 and GM-CSF signaling; PD-1 signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; RET signaling; PI3K Cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; PECAM1 interactions; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "90" "0" "58.2" "64.4" "90.6" "263.0" "118.7" "80.5" "135.3" "77.9" "95.8" "338.7" "405.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "13" "4" "6" "2" "285" "32.9" "4.72" "1276.42" "7.17" "4" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "7" "2" "342.4" "347.7" "614.5" "3065.2" "960.1" "235.1" "414.2" "336.1" "309.8" "595.9" "457.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "8" "2" "4" "2" "313" "34.8" "5.60" "748.23" "7.16" "2" "2" "" "mitochondrion" "" "" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "31.4" "35.3" "64.1" "393.1" "122.5" "32.1" "64.0" "56.1" "44.9" "94.6" "76.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "2" "2" "4" "1" "866" "101.2" "7.42" "646.78" "7.16" "2" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; hsa:80155; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "1" "58.8" "54.2" "78.9" "322.3" "128.6" "66.9" "129.5" "95.5" "111.3" "355.8" "369.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UDY4" "DnaJ homolog subfamily B member 4 OS=Homo sapiens OX=9606 GN=DNAJB4 PE=1 SV=1" "9" "2" "4" "1" "337" "37.8" "8.50" "703.00" "7.15" "2" "2" "stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00226, Pf01556" "11080" "ENSG00000162616" "DNAJB4" "B2R824; hsa:11080; Q13431; Q9UDY4" "" "VEGFA-VEGFR2 signaling" "1" "0" "18.7" "16.9" "21.9" "29.0" "21.9" "22.6" "46.6" "17.7" "25.1" "64.7" "47.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "8" "2" "3" "2" "372" "41.9" "7.31" "282.42" "7.14" "1" "2" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "GDP-fucose biosynthesis" "" "1" "0" "109.0" "95.7" "114.0" "217.3" "113.2" "82.7" "203.5" "91.0" "96.1" "230.1" "148.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TAM2" "Tetratricopeptide repeat protein 8 OS=Homo sapiens OX=9606 GN=TTC8 PE=1 SV=2" "6" "2" "4" "2" "541" "61.5" "6.80" "604.91" "7.14" "2" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13176, Pf13432" "123016" "ENSG00000165533" "TTC8" "A6NFG2; B3KWA5; hsa:123016; Q67B97; Q86SY0; Q86TV9; Q86U26; Q8NDH9; Q8TAM2; Q96DG8" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "52.3" "56.7" "70.7" "138.7" "91.0" "68.7" "121.5" "92.2" "185.8" "398.0" "305.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "7" "2" "4" "2" "420" "46.9" "8.54" "875.54" "7.12" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "mRNA Splicing - Major Pathway" "" "1" "0" "117.6" "113.3" "145.0" "364.7" "172.2" "116.7" "305.1" "114.3" "175.2" "527.8" "430.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12899" "Tripartite motif-containing protein 26 OS=Homo sapiens OX=9606 GN=TRIM26 PE=1 SV=1" "5" "2" "4" "2" "539" "62.1" "5.03" "876.48" "7.12" "2" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "7726" "ENSG00000137313; ENSG00000226060; ENSG00000228881; ENSG00000230230; ENSG00000231002; ENSG00000231641; ENSG00000234046; ENSG00000234127" "TRIM26" "A6NG96; hsa:7726; Q12899; Q5SRL2" "Interferon gamma signaling" "" "1" "0" "8.0" "15.2" "13.4" "36.5" "21.0" "15.7" "29.7" "13.4" "15.0" "44.3" "28.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05386" "60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1" "34" "3" "6" "2" "114" "11.5" "4.32" "1493.30" "7.12" "3" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;other molecular function" "Pf00428" "6176" "ENSG00000137818" "RPLP1" "A6NIB2; hsa:6176; P05386" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "223.7" "249.3" "401.2" "1567.4" "476.1" "170.2" "588.4" "274.0" "326.5" "2048.1" "1125.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92558" "Wiskott-Aldrich syndrome protein family member 1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "4" "2" "4" "2" "559" "61.6" "6.46" "903.43" "7.10" "2" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "8" "0" "185.5" "157.7" "201.8" "361.8" "240.4" "207.2" "377.0" "139.8" "285.1" "779.4" "599.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "13" "2" "4" "1" "191" "22.2" "5.86" "878.46" "7.10" "2" "2" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6; Factors involved in megakaryocyte development and platelet production" "Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; 22q11.2 copy number variation syndrome" "5" "0" "44.9" "40.3" "80.4" "323.2" "138.7" "50.0" "112.8" "69.0" "73.7" "120.0" "80.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2J2" "Band 4.1-like protein 3 OS=Homo sapiens OX=9606 GN=EPB41L3 PE=1 SV=2" "2" "2" "4" "1" "1087" "120.6" "5.19" "764.22" "7.09" "2" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "23136" "ENSG00000082397" "EPB41L3" "B7Z4I5; F5GX05; hsa:23136; O95713; Q9BRP5; Q9Y2J2" "Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "Splicing factor NOVA regulated synaptic proteins" "4" "0" "57.9" "51.6" "60.0" "159.3" "78.2" "51.6" "81.3" "53.2" "48.0" "410.6" "352.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "6" "3" "5" "3" "585" "63.8" "9.04" "1170.82" "7.08" "3" "2" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "0" "254.0" "238.4" "308.6" "598.8" "365.9" "237.7" "577.9" "229.7" "339.3" "890.9" "762.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "8" "2" "5" "2" "360" "41.5" "4.91" "1154.67" "7.06" "2" "2" "other biological processes" "other cell component" "enzyme regulator activity" "Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "" "2q37 copy number variation syndrome" "1" "0" "56.6" "54.8" "81.0" "384.2" "149.2" "27.7" "51.7" "72.0" "53.3" "223.3" "374.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "6" "2" "4" "2" "212" "23.8" "8.27" "916.88" "7.06" "2" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "3" "0" "40.2" "38.2" "47.6" "149.7" "64.6" "34.8" "73.1" "46.7" "51.1" "133.8" "133.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "3" "3" "5" "3" "1097" "123.6" "4.94" "670.32" "7.03" "2" "3" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "vRNP Assembly" "" "1" "0" "9.9" "9.1" "12.8" "78.3" "26.8" "9.3" "22.8" "16.8" "13.2" "66.5" "82.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "14" "2" "4" "2" "158" "18.0" "6.74" "991.30" "7.01" "2" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "" "VEGFA-VEGFR2 signaling; 11p11.2 copy number variation syndrome" "2" "0" "130.3" "127.0" "185.6" "748.9" "274.8" "123.2" "275.2" "141.0" "134.1" "391.1" "236.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78406" "mRNA export factor OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "8" "3" "5" "3" "368" "40.9" "7.83" "865.74" "6.97" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "Transcriptional regulation by small RNAs; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "30" "0" "455.8" "337.8" "567.3" "1275.7" "683.5" "469.8" "996.5" "408.2" "714.1" "2511.7" "2369.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H9J2" "39S ribosomal protein L44, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "12" "3" "5" "3" "332" "37.5" "8.40" "1549.42" "6.96" "3" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "167.0" "153.2" "227.4" "681.2" "310.8" "168.9" "306.6" "176.0" "210.8" "567.1" "464.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61513" "60S ribosomal protein L37a OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2" "23" "2" "3" "2" "92" "10.3" "10.43" "295.15" "6.96" "1" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01780" "6168" "ENSG00000197756" "RPL37A" "hsa:6168; P12751; P61513; Q6FGF5" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "271.9" "301.6" "233.7" "606.6" "267.2" "194.0" "462.2" "390.8" "284.3" "1128.5" "780.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "10" "2" "5" "2" "207" "22.0" "9.38" "1025.01" "6.95" "2" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "2" "0" "263.0" "191.7" "380.8" "1085.8" "482.1" "184.3" "291.8" "254.4" "292.3" "592.1" "617.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BYD1" "39S ribosomal protein L13, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "8" "1" "2" "1" "178" "20.7" "9.16" "683.18" "6.95" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "40.8" "51.5" "60.8" "183.9" "70.8" "54.8" "81.9" "55.9" "48.6" "140.3" "137.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61927" "60S ribosomal protein L37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2" "37" "8" "11" "8" "97" "11.1" "11.74" "2224.12" "6.94" "8" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01907" "6167" "ENSG00000145592" "RPL37" "B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "3538.3" "2577.6" "3211.5" "5355.1" "3466.9" "2827.4" "5464.6" "1895.6" "2517.1" "4583.2" "1985.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96A72" "Protein mago nashi homolog 2 OS=Homo sapiens OX=9606 GN=MAGOHB PE=1 SV=1" "15" "2" "4" "2" "148" "17.3" "6.39" "797.79" "6.93" "2" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf02792" "55110" "ENSG00000111196" "MAGOHB" "hsa:55110; Q96A72" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "6" "0" "10.4" "11.4" "18.8" "161.4" "44.9" "6.7" "23.1" "20.9" "19.0" "117.2" "150.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "4" "2" "3" "2" "660" "74.4" "8.16" "233.60" "6.92" "1" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "TYSND1 cleaves peroxisomal proteins" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "8" "0" "33.1" "31.7" "47.1" "107.7" "52.4" "45.4" "93.2" "36.6" "60.6" "304.6" "307.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "4" "1" "4" "1" "314" "35.8" "4.74" "687.40" "6.92" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Macroautophagy" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism" "5" "0" "53.4" "58.3" "93.0" "357.2" "137.0" "53.9" "111.3" "92.5" "84.0" "204.6" "164.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "3" "2" "3" "2" "911" "99.9" "7.55" "440.08" "6.90" "1" "2" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "Envelope proteins and their potential roles in EDMD physiopathology" "12" "0" "53.7" "56.0" "65.2" "211.7" "95.2" "58.8" "94.5" "60.9" "113.1" "594.9" "773.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12873" "Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3" "2" "2" "3" "1" "2000" "226.5" "7.30" "359.53" "6.90" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1107" "ENSG00000170004" "CHD3" "D3DTQ9; E9PG89; hsa:1107; Q12873; Q9Y4I0" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation; SUMOylation of chromatin organization proteins" "Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q3SY69" "Mitochondrial 10-formyltetrahydrofolate dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH1L2 PE=1 SV=2" "5" "3" "4" "3" "923" "101.7" "6.52" "624.62" "6.89" "2" "2" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00171, Pf00550, Pf00551, Pf02911" "160428" "ENSG00000136010" "ALDH1L2" "hsa:160428; Q3SY68; Q3SY69; Q68D62; Q6AI55; Q8N922" "Metabolism of folate and pterines" "" "1" "0" "44.2" "39.8" "55.2" "199.0" "72.2" "39.6" "78.7" "45.6" "72.2" "166.5" "156.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "3" "2" "4" "2" "683" "77.5" "9.50" "634.35" "6.89" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "15.6" "15.2" "18.9" "52.3" "21.2" "13.3" "28.1" "28.5" "81.4" "483.0" "352.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43920" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 OS=Homo sapiens OX=9606 GN=NDUFS5 PE=1 SV=3" "24" "2" "3" "2" "106" "12.5" "9.14" "253.81" "6.89" "1" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf10200" "4725" "ENSG00000168653" "NDUFS5" "hsa:4725; O43920" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "241.3" "149.9" "193.1" "278.7" "224.2" "158.8" "233.9" "178.7" "209.0" "359.0" "306.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "12" "3" "5" "3" "213" "23.9" "8.76" "1065.78" "6.86" "3" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "Pyroptosis; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "431.4" "310.6" "485.4" "1023.4" "579.2" "345.3" "736.2" "354.2" "585.4" "1181.8" "757.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N4B1" "Sesquipedalian-1 OS=Homo sapiens OX=9606 GN=PHETA1 PE=1 SV=1" "10" "2" "4" "2" "249" "27.2" "8.98" "715.99" "6.85" "2" "2" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00169" "144717" "ENSG00000198324" "PHETA1" "hsa:144717; J3KP50; Q6PJL9; Q8N4B1; Q96MH8" "" "" "0" "0" "45.2" "45.7" "54.6" "131.5" "83.6" "60.8" "70.7" "47.0" "74.6" "152.4" "100.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "12" "1" "4" "1" "95" "10.5" "8.18" "606.76" "6.85" "1" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "Mitochondrial protein import" "" "1" "0" "34.2" "40.4" "56.0" "310.0" "60.3" "19.6" "91.1" "57.1" "73.1" "410.6" "311.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N122" "Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1" "2" "2" "4" "2" "1335" "148.9" "6.89" "591.43" "6.82" "2" "2" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf02985, Pf14538" "57521" "ENSG00000141564" "RPTOR" "B2RN36; C6KEF2; F5H7J5; hsa:57521; Q8N122; Q8N4V9; Q8TB32; Q9P2P3" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "AMP-activated protein kinase signaling; Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of Beta-cells; Interferon type I signaling pathways" "33" "0" "32.2" "30.6" "38.4" "109.6" "53.7" "29.4" "70.5" "38.2" "43.0" "152.2" "128.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "24" "3" "5" "3" "127" "14.5" "5.38" "1097.29" "6.81" "3" "2" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "104.5" "93.9" "196.7" "2395.0" "409.2" "3.9" "116.4" "150.4" "120.2" "341.2" "451.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16891" "MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1" "4" "3" "5" "3" "758" "83.6" "6.48" "972.95" "6.81" "3" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09731" "10989" "ENSG00000132305" "IMMT" "B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2" "Cristae formation" "" "1" "0" "114.2" "94.0" "114.8" "421.6" "179.7" "90.9" "155.7" "113.7" "135.1" "508.3" "436.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60313" "Dynamin-like 120 kDa protein, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "4" "3" "4" "3" "960" "111.6" "7.87" "629.51" "6.81" "2" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Regulation of Apoptosis" "Orexin receptor pathway" "2" "0" "17.0" "23.9" "32.7" "101.1" "49.5" "21.5" "52.9" "22.3" "21.5" "133.3" "102.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WVV9" "Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1" "4" "2" "4" "1" "542" "60.0" "7.72" "698.11" "6.80" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "92906" "ENSG00000143889" "HNRNPLL" "hsa:92906; Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q8WVV9; Q96HR5" "" "" "0" "0" "32.3" "36.6" "32.1" "98.1" "49.2" "40.3" "60.1" "34.4" "39.7" "160.8" "116.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EY7" "Pentatricopeptide repeat domain-containing protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "5" "2" "4" "2" "689" "78.5" "6.42" "777.31" "6.78" "2" "2" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "13.6" "11.7" "12.1" "45.6" "17.8" "8.5" "20.8" "11.9" "18.6" "59.2" "103.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00403" "Cytochrome c oxidase subunit 2 OS=Homo sapiens OX=9606 GN=MT-CO2 PE=1 SV=1" "12" "2" "3" "2" "227" "25.5" "4.82" "560.01" "6.78" "1" "2" "other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00116, Pf02790" "4513" "ENSG00000198712" "MT-CO2" "hsa:4513; P00403; Q37526" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway" "10" "0" "15.2" "13.8" "29.2" "130.7" "41.2" "15.7" "28.4" "26.1" "33.6" "69.5" "94.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein PURH OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "5" "3" "5" "3" "592" "64.6" "6.71" "906.22" "6.78" "3" "2" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "One-carbon metabolism" "3" "0" "72.5" "84.1" "144.6" "1060.9" "265.7" "45.3" "115.3" "139.3" "117.8" "290.8" "303.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "4" "2" "4" "2" "721" "82.1" "6.95" "793.86" "6.78" "2" "2" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; hsa:9209; Q68CV3; Q9NXH5; Q9Y608" "" "VEGFA-VEGFR2 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "4" "2" "4" "2" "520" "60.7" "6.77" "686.30" "6.75" "2" "2" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "21.1" "24.4" "35.9" "77.2" "52.4" "26.2" "39.7" "26.6" "32.1" "101.8" "93.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H5H4" "Zinc finger protein 768 OS=Homo sapiens OX=9606 GN=ZNF768 PE=1 SV=2" "5" "2" "3" "2" "540" "60.2" "7.97" "364.51" "6.75" "1" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf05001" "79724" "ENSG00000169957" "ZNF768" "hsa:79724; Q569L7; Q96CX4; Q9H5H4" "" "" "0" "0" "144.8" "167.5" "169.7" "536.7" "256.9" "175.1" "324.4" "188.7" "197.9" "593.7" "412.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62633" "Cellular nucleic acid-binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "16" "2" "2" "2" "177" "19.5" "7.71" "" "6.71" "" "2" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "110.3" "102.7" "188.6" "457.6" "219.6" "168.4" "208.6" "65.3" "112.7" "195.3" "158.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "3" "2" "4" "2" "711" "82.2" "7.61" "639.12" "6.69" "2" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "41.6" "31.3" "39.5" "137.3" "66.6" "31.9" "65.1" "37.9" "40.9" "144.6" "133.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H3G5" "Probable serine carboxypeptidase CPVL OS=Homo sapiens OX=9606 GN=CPVL PE=1 SV=2" "4" "2" "3" "2" "476" "54.1" "5.62" "351.83" "6.67" "1" "2" "protein metabolism" "" "other molecular function" "Pf00450" "54504" "ENSG00000106066" "CPVL" "A4D1A4; hsa:54504; Q6UX20; Q8NBL7; Q96AR7; Q9H3G5; Q9HB41" "" "" "0" "0" "51.1" "41.0" "77.6" "238.1" "90.8" "53.9" "110.9" "54.6" "83.3" "485.3" "710.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A1A4S6" "Rho GTPase-activating protein 10 OS=Homo sapiens OX=9606 GN=ARHGAP10 PE=1 SV=1" "5" "3" "5" "3" "786" "89.3" "7.18" "964.83" "6.67" "3" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00620, Pf14604, Pf16746" "79658" "ENSG00000071205" "ARHGAP10" "A1A4S6; A1L0S5; hsa:79658; Q2VPC4; Q2VPC5; Q96EV3; Q96S75" "Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "Ectoderm differentiation; Ectoderm differentiation" "6" "0" "40.4" "27.5" "42.3" "130.5" "61.8" "45.7" "88.5" "117.3" "296.7" "1097.4" "815.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "6" "3" "5" "3" "561" "64.3" "6.86" "1084.48" "6.67" "3" "2" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "6" "0" "160.8" "167.9" "256.6" "1496.1" "446.1" "60.8" "220.6" "234.3" "178.6" "505.7" "496.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "16" "2" "4" "2" "154" "15.9" "6.13" "679.78" "6.66" "2" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; hsa:6647; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation" "15" "0" "70.4" "58.2" "102.4" "453.9" "154.0" "51.5" "94.3" "93.1" "104.1" "274.9" "276.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BVQ7" "Spermatogenesis-associated protein 5-like protein 1 OS=Homo sapiens OX=9606 GN=SPATA5L1 PE=1 SV=2" "3" "2" "4" "2" "753" "80.7" "8.09" "707.55" "6.66" "2" "2" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "33.2" "32.6" "49.2" "156.3" "67.0" "36.8" "60.0" "43.4" "43.0" "130.6" "132.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "7" "2" "3" "2" "484" "54.9" "7.11" "345.88" "6.64" "1" "2" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "63.0" "78.1" "100.6" "237.3" "108.2" "81.9" "161.1" "79.6" "95.9" "229.4" "158.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "7" "2" "5" "2" "305" "35.1" "5.69" "909.19" "6.64" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "68.9" "60.5" "71.2" "254.7" "115.3" "58.7" "108.3" "65.3" "77.1" "425.0" "725.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "28" "2" "4" "2" "119" "13.3" "11.56" "602.97" "6.63" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "17.0" "12.5" "10.3" "15.6" "7.0" "6.1" "14.9" "13.2" "6.2" "26.5" "20.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3D9" "28S ribosomal protein S23, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "11" "2" "4" "2" "190" "21.8" "8.90" "681.90" "6.61" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "144.3" "123.7" "140.9" "526.4" "211.2" "140.2" "226.2" "172.0" "176.2" "528.3" "469.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "7" "2" "4" "2" "436" "49.2" "8.81" "765.64" "6.61" "2" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "Signaling by Retinoic Acid; Regulation of pyruvate dehydrogenase (PDH) complex" "T cell receptor and co-stimulatory signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; EPO receptor signaling; DNA damage response (only ATM dependent)" "19" "0" "66.2" "60.2" "63.8" "151.8" "83.1" "70.5" "107.6" "63.8" "92.1" "306.0" "325.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "2" "4" "6" "3" "2157" "228.7" "9.45" "1679.12" "6.61" "4" "2" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "411.0" "339.9" "399.9" "566.5" "464.5" "429.0" "510.2" "289.1" "463.4" "540.1" "273.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "22" "2" "3" "2" "125" "14.2" "5.26" "366.14" "6.60" "1" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "Eukaryotic Translation Termination; Methylation; rRNA modification in the nucleus and cytosol; tRNA modification in the nucleus and cytosol" "" "4" "0" "42.7" "41.4" "63.1" "118.0" "77.7" "53.7" "76.1" "51.4" "58.5" "162.3" "182.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "2" "2" "4" "2" "981" "108.8" "6.40" "643.63" "6.60" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451, Pf07714" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs; Nuclear events stimulated by ALK signaling in cancer" "Non-small cell lung cancer" "5" "0" "107.7" "110.9" "151.8" "445.0" "196.3" "102.1" "234.5" "166.1" "160.2" "381.9" "315.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "8" "3" "5" "2" "316" "35.8" "6.98" "927.73" "6.59" "3" "2" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Pregnenolone biosynthesis; Fructose biosynthesis" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Polyol pathway; Metapathway biotransformation Phase I and II" "6" "1" "241.4" "198.8" "375.2" "2101.9" "614.5" "159.4" "361.8" "230.4" "255.3" "856.2" "921.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "4" "3" "5" "3" "706" "79.9" "6.68" "1038.02" "6.59" "3" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "9" "0" "240.6" "198.2" "226.6" "575.5" "270.3" "180.2" "370.4" "161.5" "204.7" "783.4" "647.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZF9" "Uveal autoantigen with coiled-coil domains and ankyrin repeats OS=Homo sapiens OX=9606 GN=UACA PE=1 SV=2" "4" "5" "7" "5" "1416" "162.4" "7.03" "1913.82" "6.56" "5" "2" "other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf12796" "55075" "ENSG00000137831" "UACA" "G3XAG2; hsa:55075; Q14DD3; Q8N3B8; Q96NH6; Q9BZF9; Q9HCL1; Q9NWC6" "Regulation of the apoptosome activity; RHOH GTPase cycle" "" "2" "0" "37.2" "33.3" "51.3" "140.1" "57.6" "35.6" "82.8" "88.0" "247.4" "1194.1" "1013.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "4" "2" "4" "2" "668" "75.0" "9.66" "784.18" "6.53" "2" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome" "7" "0" "128.5" "114.0" "168.0" "639.3" "250.0" "117.6" "209.2" "157.9" "161.8" "360.5" "273.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "13" "3" "4" "3" "312" "35.1" "9.13" "815.70" "6.53" "2" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "173.9" "136.9" "212.0" "527.7" "259.6" "159.1" "279.4" "171.9" "258.4" "606.6" "716.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "3" "2" "4" "2" "768" "88.9" "8.48" "772.59" "6.52" "2" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Potential therapeutics for SARS; RHOBTB3 ATPase cycle" "Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "15" "0" "52.2" "62.8" "74.6" "192.5" "92.5" "49.6" "97.8" "64.9" "91.9" "430.3" "630.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "4" "1" "4" "1" "268" "30.7" "3.85" "710.11" "6.51" "1" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "116.6" "116.6" "153.1" "432.2" "205.8" "103.4" "264.3" "118.6" "124.8" "394.6" "272.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96Q05" "Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2" "2" "2" "4" "2" "1148" "128.4" "6.62" "786.43" "6.50" "2" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf08626" "83696" "ENSG00000167632" "TRAPPC9" "hsa:83696; Q4VTT3; Q658K7; Q6P149; Q6ZQT3; Q7L5C4; Q86Y21; Q96Q05; Q96SL2; Q9BQA2" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "6.5" "6.1" "9.3" "16.9" "10.7" "4.2" "7.2" "4.4" "7.1" "21.3" "23.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P0DN79" "Cystathionine beta-synthase-like protein OS=Homo sapiens OX=9606 GN=CBSL PE=1 SV=1" "4" "2" "5" "2" "551" "60.5" "6.65" "993.94" "6.49" "2" "2" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00291, Pf00571" "102724560; 875" "ENSG00000160200" "CBS" "B2R993; D3DSK4; hsa:102724560; hsa:875; P35520; Q99425; Q9BWC5" "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Vitamin D receptor pathway; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis; Ciliary landscape" "13" "0" "16.0" "26.1" "42.5" "510.8" "107.1" "6.7" "78.6" "51.5" "30.4" "210.7" "148.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q67FW5" "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 OS=Homo sapiens OX=9606 GN=B3GNTL1 PE=2 SV=2" "8" "3" "5" "3" "361" "40.7" "7.40" "976.65" "6.49" "3" "2" "" "" "other molecular function" "Pf00535" "146712" "ENSG00000175711; ENSG00000277033" "B3GNTL1" "hsa:146712; Q67FW5; Q6GV30; Q8WUT3" "O-linked glycosylation of mucins" "" "1" "0" "31.8" "33.6" "47.5" "173.0" "74.3" "43.9" "106.2" "141.3" "437.6" "987.0" "725.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11137" "Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4" "1" "1" "3" "1" "1827" "199.4" "4.91" "" "6.48" "" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418, Pf08377" "4133" "ENSG00000078018" "MAP2" "hsa:4133; P11137; Q17S04; Q8IUX2; Q99975; Q99976" "" "Melatonin metabolism and effects; MAPK cascade; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "4" "0" "82.0" "72.2" "91.1" "611.5" "126.8" "67.5" "133.9" "89.8" "109.1" "920.1" "738.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "5" "2" "4" "2" "439" "48.9" "5.29" "614.76" "6.47" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "35.1" "30.5" "47.6" "256.3" "68.1" "28.7" "74.8" "37.4" "56.4" "362.0" "300.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "3" "2" "3" "2" "725" "81.3" "7.83" "638.41" "6.46" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "RHO GTPases Activate Formins; Separation of Sister Chromatids; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation" "10" "0" "42.3" "30.6" "50.4" "179.4" "70.4" "40.9" "76.6" "44.9" "57.3" "186.8" "194.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60568" "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1" "4" "2" "3" "2" "738" "84.7" "6.05" "463.84" "6.45" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf03171" "8985" "ENSG00000106397" "PLOD3" "B2R6W6; hsa:8985; O60568; Q540C3" "Collagen biosynthesis and modifying enzymes" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "3" "0" "4.7" "0.0" "10.9" "34.0" "14.6" "6.8" "17.9" "5.9" "10.8" "17.7" "8.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82663" "28S ribosomal protein S25, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1" "13" "2" "4" "2" "173" "20.1" "8.82" "736.58" "6.43" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "64432" "ENSG00000131368" "MRPS25" "B4DFJ5; B4DQG6; hsa:64432; P82663; Q9H7P5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "20.7" "14.5" "29.3" "103.1" "41.5" "26.0" "45.4" "20.3" "28.7" "76.0" "57.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "1" "2" "2" "2" "4374" "481.6" "5.22" "" "6.42" "" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "" "2" "0" "69.3" "70.9" "105.9" "314.4" "147.9" "96.7" "172.2" "100.8" "100.7" "295.8" "228.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6N069" "N-alpha-acetyltransferase 16, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA16 PE=1 SV=2" "3" "2" "4" "1" "864" "101.4" "7.87" "689.39" "6.41" "2" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf07719, Pf12569" "79612" "ENSG00000172766" "NAA16" "B0QZ59; hsa:79612; Q5VSP9; Q6N069; Q6P2D5; Q8N5J3; Q8N870" "" "" "0" "0" "8.1" "9.8" "10.6" "16.0" "10.4" "8.0" "13.6" "7.4" "19.1" "153.0" "223.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4C2" "TRPM8 channel-associated factor 1 OS=Homo sapiens OX=9606 GN=TCAF1 PE=1 SV=3" "2" "2" "4" "2" "921" "102.1" "6.54" "616.08" "6.40" "2" "2" "other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13402, Pf17291" "9747" "ENSG00000198420" "TCAF1" "A8K6E0; hsa:9747; Q75KM8; Q75KM9; Q7L665; Q9BW63; Q9Y4C2" "" "" "0" "0" "58.4" "63.7" "80.6" "215.0" "107.1" "75.7" "139.7" "90.3" "135.8" "594.4" "852.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "9" "2" "2" "2" "365" "40.8" "6.04" "381.45" "6.38" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "" "Nanoparticle triggered autophagic cell death" "1" "0" "18.4" "31.0" "44.9" "298.2" "93.3" "21.1" "51.7" "54.4" "50.0" "89.6" "88.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQ39" "ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1" "5" "3" "5" "3" "737" "82.5" "9.17" "1088.28" "6.38" "3" "2" "" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf00270, Pf00271, Pf08152" "79009" "ENSG00000107625" "DDX50" "hsa:79009; Q5VX37; Q8WV76; Q9BQ39; Q9BWI8" "" "" "0" "0" "77.9" "71.7" "86.9" "271.0" "127.8" "73.0" "160.9" "81.0" "85.1" "327.6" "210.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3B7" "39S ribosomal protein L11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "13" "2" "4" "2" "192" "20.7" "9.91" "757.94" "6.38" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "124.6" "122.3" "149.3" "411.3" "197.4" "109.2" "221.6" "141.3" "145.7" "454.8" "388.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02978" "Mitochondrial 2-oxoglutarate/malate carrier protein OS=Homo sapiens OX=9606 GN=SLC25A11 PE=1 SV=3" "4" "1" "4" "1" "314" "34.0" "9.91" "750.86" "6.37" "1" "1" "other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion" "transporter activity" "Pf00153" "8402" "ENSG00000108528" "SLC25A11" "F5GY65; hsa:8402; O75537; Q02978; Q969P7" "Gluconeogenesis" "VEGFA-VEGFR2 signaling" "2" "0" "17.2" "19.1" "31.3" "149.3" "42.1" "15.5" "50.3" "28.9" "29.1" "181.6" "181.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WWK9" "Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1" "4" "3" "4" "3" "683" "76.9" "9.41" "1203.04" "6.37" "3" "1" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "" "Pf15297" "26586" "ENSG00000136108" "CKAP2" "A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4" "" "" "0" "0" "366.8" "280.9" "341.2" "503.8" "460.7" "283.8" "488.3" "283.7" "374.8" "679.6" "408.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TDN6" "Ribosome biogenesis protein BRX1 homolog OS=Homo sapiens OX=9606 GN=BRIX1 PE=1 SV=2" "9" "3" "4" "3" "353" "41.4" "9.92" "731.73" "6.36" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04427" "55299" "ENSG00000113460" "BRIX1" "A8K0P5; hsa:55299; Q3ZTT4; Q8N453; Q8TDN6; Q96DH1" "" "Gastric cancer network 2" "1" "0" "173.6" "183.8" "200.4" "490.3" "252.6" "167.8" "353.2" "167.0" "172.4" "543.9" "306.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15031" "Probable leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "3" "2" "3" "2" "903" "101.9" "8.22" "349.34" "6.36" "1" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Mitochondrial tRNA aminoacylation" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "4" "0" "10.7" "8.8" "10.6" "35.7" "18.3" "7.0" "15.4" "10.0" "10.1" "34.1" "35.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "3" "3" "6" "3" "919" "103.2" "5.72" "1256.31" "6.36" "3" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "181.5" "165.3" "235.1" "722.1" "294.2" "120.6" "205.0" "171.9" "176.1" "278.7" "260.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "26" "5" "9" "5" "209" "24.0" "7.81" "3191.70" "6.35" "5" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Apoptosis induced DNA fragmentation" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "4" "0" "703.7" "498.9" "703.9" "1828.6" "988.7" "534.4" "724.8" "495.8" "674.0" "1127.2" "1248.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "8" "2" "4" "2" "354" "39.1" "6.44" "617.77" "6.34" "2" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Activation of ATR in response to replication stress" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "10.4" "8.0" "12.5" "34.0" "14.7" "5.9" "22.9" "10.7" "6.5" "48.9" "42.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "5" "2" "3" "2" "669" "72.4" "8.34" "279.18" "6.34" "1" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "28.1" "21.8" "30.5" "107.2" "54.7" "28.4" "58.1" "24.0" "39.2" "113.9" "110.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "5" "2" "3" "2" "414" "44.7" "6.19" "400.26" "6.32" "1" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "" "MECP2 and associated Rett syndrome" "1" "0" "110.6" "101.9" "130.3" "440.7" "188.2" "117.7" "220.3" "123.8" "151.8" "460.8" "328.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "8" "3" "5" "3" "414" "44.7" "6.25" "1271.83" "6.32" "2" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "8" "0" "109.1" "91.9" "139.1" "376.8" "169.1" "99.5" "181.5" "123.5" "132.7" "868.0" "1444.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "25" "1" "1" "1" "89" "10.4" "7.40" "" "6.32" "" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "HCMV Early Events; Neutrophil degranulation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Separation of Sister Chromatids; Intraflagellar transport; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "27" "0" "22.7" "17.2" "46.6" "268.6" "91.9" "47.5" "111.0" "37.5" "53.9" "212.0" "102.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "3" "1" "2" "1" "453" "48.7" "8.95" "612.82" "6.31" "1" "1" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "Citric acid cycle (TCA cycle); Glyoxylate metabolism and glycine degradation; Lysine catabolism" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "10" "0" "269.6" "225.8" "241.7" "724.4" "332.2" "229.4" "274.9" "178.6" "257.9" "315.0" "193.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "4" "2" "4" "2" "380" "39.8" "8.94" "1076.16" "6.31" "2" "2" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "Integrin-mediated cell adhesion; Focal adhesion" "5" "0" "16.4" "12.9" "19.6" "166.8" "45.7" "21.5" "55.3" "26.3" "34.1" "200.8" "109.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09936" "Ubiquitin carboxyl-terminal hydrolase isozyme L1 OS=Homo sapiens OX=9606 GN=UCHL1 PE=1 SV=2" "14" "3" "4" "3" "223" "24.8" "5.48" "608.98" "6.30" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01088" "7345" "ENSG00000154277" "UCHL1" "hsa:7345; P09936; Q4W5K6; Q71UM0" "UCH proteinases" "Proteasome degradation; Parkinson's disease pathway; Hepatitis C and hepatocellular carcinoma" "4" "0" "190.0" "179.1" "300.5" "1626.2" "487.1" "93.1" "235.5" "221.4" "186.2" "441.9" "513.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "2" "2" "4" "2" "1626" "183.2" "8.00" "698.97" "6.30" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "SUMOylation of DNA replication proteins" "" "1" "0" "57.1" "51.0" "66.1" "203.4" "98.8" "75.5" "150.1" "64.6" "67.4" "309.5" "205.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "17" "2" "6" "2" "174" "19.9" "5.72" "2138.43" "6.30" "2" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "" "6" "0" "27.1" "34.2" "33.9" "153.1" "54.3" "18.9" "29.4" "26.0" "20.1" "58.3" "60.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "4" "2" "4" "2" "434" "48.3" "7.93" "646.50" "6.30" "2" "2" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialic acid metabolism" "" "1" "0" "6.6" "8.0" "14.4" "29.0" "19.6" "13.4" "27.8" "12.5" "15.8" "46.9" "42.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "8" "2" "5" "2" "358" "40.5" "6.18" "1204.43" "6.29" "2" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "2" "0" "38.5" "35.4" "48.1" "234.7" "80.7" "35.5" "102.1" "57.3" "66.2" "273.4" "194.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit alpha OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "7" "2" "2" "2" "410" "46.6" "7.37" "397.23" "6.28" "1" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Separation of Sister Chromatids; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium" "17" "0" "30.0" "28.7" "57.0" "262.7" "97.0" "32.1" "91.5" "53.8" "45.9" "201.5" "138.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "8" "2" "4" "2" "357" "38.3" "7.97" "725.48" "6.26" "2" "2" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "Disorders of fructose metabolism; Polyol pathway" "4" "0" "4.1" "3.9" "8.6" "20.9" "9.3" "8.9" "8.2" "3.8" "7.7" "22.3" "19.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "4" "2" "5" "2" "482" "55.1" "5.48" "1383.97" "6.25" "2" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; MECP2 regulates transcription of neuronal ligands; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome causing genes; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "53" "0" "310.3" "258.2" "364.2" "923.9" "450.6" "260.7" "443.8" "240.9" "294.2" "786.0" "594.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "6" "2" "4" "2" "429" "47.4" "5.60" "668.58" "6.25" "2" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "UCH proteinases; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; HATs acetylate histones; DNA Damage Recognition in GG-NER" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "10" "0" "68.5" "50.1" "69.6" "243.9" "92.5" "60.4" "96.8" "57.1" "52.2" "161.3" "111.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "5" "2" "4" "2" "476" "54.8" "6.61" "646.68" "6.24" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "mRNA processing" "4" "0" "51.1" "48.7" "68.8" "228.1" "84.6" "56.6" "88.9" "63.4" "74.6" "200.7" "191.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "4" "2" "4" "2" "575" "61.6" "6.95" "638.96" "6.24" "2" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Regulation of HSF1-mediated heat shock response" "Cell interactions of the pancreatic cancer microenvironment" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6PGP7" "Tetratricopeptide repeat protein 37 OS=Homo sapiens OX=9606 GN=TTC37 PE=1 SV=1" "2" "2" "3" "2" "1564" "175.4" "7.53" "412.83" "6.24" "1" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf13181, Pf13432" "9652" "ENSG00000198677" "SKIC3" "hsa:9652; O15077; Q6PGP7; Q6PJI3" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "22.3" "21.9" "30.3" "91.5" "46.9" "29.9" "56.5" "33.5" "39.4" "180.4" "256.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "20" "4" "6" "4" "260" "29.9" "5.73" "1728.48" "6.23" "4" "2" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "149.2" "128.0" "204.0" "719.8" "290.4" "150.5" "298.0" "165.2" "222.9" "641.8" "535.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14859" "POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2" "5" "2" "3" "2" "743" "76.4" "6.81" "468.46" "6.22" "1" "2" "RNA metabolism OR transcription;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157, Pf19536" "5451" "ENSG00000143190" "POU2F1" "B1AL91; B1AL93; B4E029; hsa:5451; J3KP77; P14859; Q5TBT7; Q6PK46; Q8NEU9; Q9BPV1" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling" "Integrated cancer pathway" "6" "0" "26.9" "27.2" "45.1" "111.5" "51.7" "24.5" "56.1" "20.5" "31.7" "86.2" "75.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "11" "1" "2" "1" "180" "19.6" "6.02" "520.51" "6.21" "1" "1" "other metabolic processes;transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95573" "Long-chain-fatty-acid--CoA ligase 3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=3" "3" "2" "4" "2" "720" "80.4" "8.38" "538.10" "6.18" "2" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2181" "ENSG00000123983" "ACSL3" "hsa:2181; O95573; Q60I92; Q8IUM9" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "14" "0" "129.1" "138.9" "175.5" "555.4" "243.4" "128.2" "204.1" "138.5" "164.4" "398.5" "316.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "9" "2" "4" "2" "342" "38.9" "5.52" "761.36" "6.17" "2" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "4" "0" "105.0" "103.3" "116.7" "296.8" "137.9" "95.2" "164.3" "101.5" "107.0" "275.9" "193.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00443" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2" "1" "1" "1" "1" "1686" "190.6" "8.02" "" "6.15" "" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5286" "ENSG00000011405" "PIK3C2A" "B0LPH2; B4E2G4; hsa:5286; O00443; Q14CQ9" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "14" "0" "11.2" "10.1" "6.8" "14.8" "5.1" "9.5" "15.0" "7.2" "4.4" "45.7" "56.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "3" "2" "4" "2" "1303" "140.2" "6.27" "668.09" "6.14" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "10.5" "7.3" "12.9" "28.4" "17.3" "12.8" "21.5" "10.5" "13.4" "25.5" "16.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "3" "2" "4" "2" "717" "81.6" "7.14" "639.38" "6.14" "2" "2" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "mRNA Splicing - Major Pathway" "" "1" "0" "54.0" "67.3" "87.3" "349.1" "157.8" "56.8" "116.3" "71.5" "52.1" "131.9" "77.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "4" "3" "5" "3" "615" "70.7" "9.36" "917.78" "6.13" "3" "2" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOD GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "Gastric cancer network 2; ATM signaling in development and disease ; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "19" "0" "316.2" "257.9" "447.8" "1470.2" "645.3" "264.9" "553.7" "341.9" "423.1" "1341.7" "998.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4W6" "AFG3-like protein 2 OS=Homo sapiens OX=9606 GN=AFG3L2 PE=1 SV=2" "3" "3" "5" "3" "797" "88.5" "8.66" "1000.39" "6.12" "3" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "10939" "ENSG00000141385" "AFG3L2" "hsa:10939; Q6P1L0; Q9Y4W6" "Processing of SMDT1" "Ciliary landscape" "2" "0" "166.7" "153.5" "207.2" "536.6" "244.1" "153.9" "338.8" "149.9" "179.9" "719.4" "574.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P47914" "60S ribosomal protein L29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "13" "2" "3" "2" "159" "17.7" "11.66" "440.48" "6.11" "1" "2" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "496.9" "410.3" "499.1" "1080.6" "544.3" "393.0" "883.9" "330.5" "418.2" "971.3" "444.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "8" "2" "4" "2" "272" "31.4" "5.91" "622.03" "6.10" "2" "2" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "" "Ciliary landscape" "1" "0" "260.9" "217.3" "302.3" "1007.3" "424.3" "229.4" "429.7" "233.4" "320.2" "1084.1" "785.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "4" "2" "4" "2" "683" "78.5" "6.87" "484.64" "6.10" "2" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Signaling by CSF1 (M-CSF) in myeloid cells" "" "4" "0" "62.1" "39.8" "60.5" "123.3" "92.1" "74.4" "101.0" "41.4" "71.3" "153.9" "140.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "13" "3" "5" "3" "249" "28.7" "6.02" "1302.04" "6.09" "3" "2" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "188.4" "169.7" "267.9" "1351.9" "490.2" "196.1" "439.6" "258.5" "287.7" "795.2" "498.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "3" "2" "3" "1" "745" "82.8" "7.37" "270.95" "6.08" "1" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01909, Pf04926, Pf04928" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "41.0" "31.4" "53.8" "124.1" "63.8" "41.1" "61.1" "33.5" "46.1" "130.8" "127.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "20" "2" "4" "2" "165" "19.0" "5.21" "709.46" "6.08" "2" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "45.1" "38.5" "56.0" "122.7" "63.8" "30.6" "72.6" "43.2" "52.7" "192.0" "277.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "9" "2" "4" "2" "199" "23.6" "9.01" "617.45" "6.04" "2" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "mRNA Splicing - Major Pathway" "" "1" "0" "334.1" "210.6" "296.4" "623.0" "344.4" "209.9" "363.1" "202.8" "298.5" "1114.6" "1258.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "19" "3" "5" "3" "149" "17.3" "5.97" "943.56" "6.03" "3" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Nuclear signaling by ERBB4" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "7" "0" "171.5" "168.2" "211.1" "1332.3" "418.4" "137.7" "214.1" "180.1" "192.5" "432.4" "387.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "9" "2" "4" "2" "225" "25.7" "9.25" "707.16" "6.02" "2" "2" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "110.0" "86.0" "103.4" "258.4" "124.2" "73.5" "174.1" "95.6" "109.8" "369.1" "330.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "3" "2" "4" "2" "744" "82.3" "7.78" "632.82" "6.02" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "Ciliary landscape" "3" "0" "13.1" "11.1" "16.8" "46.3" "22.4" "12.4" "18.0" "18.7" "30.0" "245.9" "235.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "3" "2" "4" "2" "622" "69.8" "6.84" "616.50" "6.00" "2" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; hsa:51428; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "" "4" "0" "103.7" "104.9" "132.9" "403.8" "182.4" "116.4" "211.0" "137.2" "152.3" "683.5" "723.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "6" "2" "4" "1" "325" "36.6" "6.79" "519.64" "5.99" "2" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Glutathione conjugation; Formation of xylulose-5-phosphate" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H7D0" "Dedicator of cytokinesis protein 5 OS=Homo sapiens OX=9606 GN=DOCK5 PE=1 SV=3" "1" "2" "4" "2" "1870" "215.2" "7.96" "656.54" "5.98" "2" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf06920, Pf14429, Pf16172, Pf20421, Pf20422" "80005" "ENSG00000147459" "DOCK5" "B2RNY0; hsa:80005; Q5XKD5; Q6AI11; Q6PJS6; Q6ZTS6; Q9H7D0" "RHOG GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "Ciliary landscape" "4" "0" "0.0" "2.3" "0.0" "6.2" "4.8" "0.0" "5.0" "0.5" "5.9" "67.0" "75.3" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92738" "USP6 N-terminal-like protein OS=Homo sapiens OX=9606 GN=USP6NL PE=1 SV=3" "3" "2" "4" "2" "828" "94.0" "9.07" "762.48" "5.97" "2" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9712" "ENSG00000148429" "USP6NL" "A8KA79; hsa:9712; Q15400; Q5VV10; Q7L0K9; Q92738" "Retrograde transport at the Trans-Golgi-Network" "EGF/EGFR signaling pathway" "2" "0" "31.7" "20.3" "25.4" "34.5" "29.4" "23.7" "32.2" "28.8" "39.1" "75.4" "40.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "2" "2" "4" "2" "1272" "147.7" "5.69" "645.71" "5.96" "2" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "2" "0" "62.9" "44.2" "70.5" "197.8" "95.5" "59.7" "102.4" "51.6" "66.2" "146.9" "119.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "3" "2" "4" "2" "876" "97.1" "4.78" "587.56" "5.96" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Neutrophil degranulation; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Assembly of the ORC complex at the origin of replication; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "15" "0" "116.5" "119.4" "163.0" "689.9" "267.4" "79.7" "136.2" "112.6" "118.6" "238.3" "247.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "8" "3" "5" "3" "406" "46.6" "6.16" "1196.89" "5.95" "3" "2" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "120.4" "137.9" "221.3" "683.5" "301.3" "145.7" "320.3" "160.4" "247.7" "662.3" "569.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "2" "1" "4" "1" "510" "54.6" "8.76" "745.70" "5.95" "1" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "8" "0" "10.1" "7.9" "10.9" "95.6" "17.2" "2.9" "10.1" "7.8" "7.6" "20.9" "24.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "8" "2" "4" "2" "308" "33.9" "4.84" "779.37" "5.93" "2" "2" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "NoRC negatively regulates rRNA expression" "" "1" "0" "11.7" "9.2" "17.3" "35.2" "20.8" "19.0" "25.7" "12.1" "18.3" "43.7" "33.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "2" "2" "4" "2" "1475" "153.8" "8.73" "698.94" "5.91" "2" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "59.0" "44.5" "57.6" "78.9" "62.0" "48.0" "82.6" "39.2" "50.7" "78.7" "60.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IXI1" "Mitochondrial Rho GTPase 2 OS=Homo sapiens OX=9606 GN=RHOT2 PE=1 SV=2" "4" "2" "4" "2" "618" "68.1" "5.86" "719.00" "5.91" "2" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00071, Pf08355, Pf08356" "89941" "ENSG00000140983" "RHOT2" "A2IDC2; hsa:89941; Q8IXI1; Q8NF53; Q96C13; Q96S17; Q9BT60; Q9H7M8" "RHOT2 GTPase cycle" "" "1" "0" "7.8" "8.7" "15.9" "79.9" "26.6" "10.6" "22.5" "19.0" "19.7" "45.9" "50.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "14" "4" "6" "2" "286" "33.7" "9.36" "1458.81" "5.90" "4" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "RHOJ GTPase cycle; RHOH GTPase cycle" "" "2" "0" "79.0" "72.6" "105.7" "243.7" "135.9" "72.6" "174.7" "94.6" "104.2" "425.2" "370.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75386" "Tubby-related protein 3 OS=Homo sapiens OX=9606 GN=TULP3 PE=1 SV=2" "6" "2" "3" "2" "442" "49.6" "7.74" "321.51" "5.90" "1" "2" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01167, Pf16322" "7289" "ENSG00000078246" "TULP3" "B3KNB7; B7Z6A2; D3DUQ4; F8WBZ9; hsa:7289; O75386; Q8N5B0" "Hedgehog 'off' state" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)" "3" "0" "62.4" "52.9" "82.7" "155.3" "83.9" "70.0" "115.5" "61.5" "131.3" "400.3" "284.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12923" "Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens OX=9606 GN=PTPN13 PE=1 SV=2" "1" "1" "1" "1" "2485" "276.7" "6.42" "" "5.89" "" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102, Pf00373, Pf00595, Pf09379, Pf09380, Pf16599" "5783" "ENSG00000163629" "PTPN13" "B2RTR0; hsa:5783; Q12923; Q15159; Q15263; Q15264; Q15265; Q15674; Q16826; Q8IWH7; Q9NYN9; Q9UDA8" "Synthesis of PIPs at the plasma membrane; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-37 signaling" "Apoptosis modulation and signaling; Ectoderm differentiation; Ectoderm differentiation" "8" "0" "6.8" "14.7" "16.9" "32.4" "13.6" "18.6" "17.4" "15.9" "36.7" "201.7" "135.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15599" "Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens OX=9606 GN=SLC9A3R2 PE=1 SV=2" "4" "1" "2" "1" "337" "37.4" "7.93" "643.61" "5.88" "1" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf09007" "9351" "ENSG00000065054" "NHERF2" "D3DU84; D3DU85; H3BSV6; hsa:9351; O00272; O00556; Q15599; Q3KQY7" "" "" "0" "0" "24.9" "23.7" "20.7" "59.4" "28.2" "22.5" "29.2" "22.4" "31.0" "110.2" "128.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A6NMY6" "Putative annexin A2-like protein OS=Homo sapiens OX=9606 GN=ANXA2P2 PE=5 SV=2" "7" "2" "4" "2" "339" "38.6" "6.95" "654.50" "5.88" "2" "2" "transport" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00191" "" "" "ANXA2P2" "A6NMY6" "" "" "0" "0" "109.2" "88.9" "91.0" "276.1" "98.0" "47.4" "97.5" "67.2" "72.8" "222.8" "182.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62995" "Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1" "7" "2" "4" "2" "288" "33.6" "11.25" "603.67" "5.87" "2" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6434" "ENSG00000136527" "TRA2B" "B4DVK2; D3DNU3; hsa:6434; O15449; P62995; Q15815; Q64283" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "5" "0" "112.1" "112.2" "166.5" "536.0" "233.9" "105.9" "245.8" "121.6" "107.2" "345.0" "196.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "2" "2" "4" "2" "1478" "164.9" "5.22" "514.75" "5.87" "2" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "" "2" "0" "24.5" "29.0" "45.0" "173.2" "78.3" "30.2" "65.3" "47.1" "47.4" "163.6" "161.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "4" "1" "1" "1" "559" "59.8" "5.29" "" "5.86" "" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950; ENSG00000274081" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "mRNA Splicing - Major Pathway" "" "1" "0" "34.4" "29.2" "47.3" "163.8" "71.1" "34.7" "75.5" "40.1" "57.8" "129.7" "95.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BWT3" "Poly(A) polymerase gamma OS=Homo sapiens OX=9606 GN=PAPOLG PE=1 SV=2" "2" "2" "4" "1" "736" "82.8" "9.14" "513.71" "5.86" "2" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01909, Pf04926, Pf04928" "64895" "ENSG00000115421" "PAPOLG" "B2RBH4; hsa:64895; Q59G05; Q969N1; Q9BWT3; Q9H8L2; Q9HAD0" "" "" "0" "1" "30.4" "29.9" "43.7" "118.5" "63.9" "37.2" "75.8" "229.5" "119.4" "702.6" "1071.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "3" "2" "4" "2" "491" "55.5" "7.15" "570.81" "5.86" "2" "2" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "9" "0" "99.9" "83.5" "143.0" "596.8" "244.9" "77.0" "199.3" "131.3" "186.0" "893.1" "1102.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "2" "2" "4" "2" "1312" "153.8" "6.89" "723.05" "5.86" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ)" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "29" "0" "89.2" "90.5" "124.4" "605.4" "222.0" "73.9" "249.7" "145.6" "157.0" "518.6" "374.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "9" "4" "6" "4" "397" "41.3" "6.92" "1133.28" "5.86" "4" "2" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Cholesterol biosynthesis" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "6" "0" "137.5" "147.2" "200.4" "1164.9" "373.9" "78.8" "148.7" "192.1" "104.3" "266.6" "255.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2" "19" "2" "4" "2" "103" "11.4" "11.36" "631.39" "5.85" "2" "2" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; RUNX1 regulates transcription of genes involved in differentiation of HSCs; SUMOylation of chromatin organization proteins; HCMV Late Events; Amyloid fiber formation; Meiotic synapsis; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; 11p11.2 copy number variation syndrome ; Type II interferon signaling" "51" "0" "103.3" "99.5" "123.5" "439.5" "171.6" "75.6" "199.9" "108.8" "117.3" "468.0" "376.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94842" "TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1" "3" "2" "4" "2" "621" "66.2" "5.06" "636.36" "5.82" "2" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "9878" "ENSG00000092203" "TOX4" "B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842" "" "" "0" "0" "34.9" "30.4" "44.6" "136.7" "66.6" "39.6" "77.5" "40.5" "56.0" "179.1" "271.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "4" "2" "3" "2" "474" "53.2" "7.08" "456.96" "5.82" "1" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "187.9" "155.6" "238.5" "734.7" "358.6" "174.0" "276.4" "154.7" "201.2" "435.8" "323.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "3" "2" "4" "2" "795" "87.2" "7.12" "640.85" "5.82" "2" "2" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "" "Amino acid metabolism" "1" "0" "38.2" "39.6" "67.7" "242.7" "97.9" "39.7" "80.3" "49.9" "87.8" "228.5" "207.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H7B4" "Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens OX=9606 GN=SMYD3 PE=1 SV=4" "4" "2" "5" "1" "428" "49.1" "7.25" "682.07" "5.82" "2" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01753" "64754" "ENSG00000185420" "SMYD3" "A8K0P0; B1AN38; hsa:64754; Q86TL8; Q8N5Z6; Q96AI5; Q9H7B4" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "18.7" "18.9" "28.9" "66.5" "41.6" "20.7" "46.0" "31.6" "47.4" "261.7" "447.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "4" "1" "3" "1" "307" "33.7" "8.21" "240.94" "5.81" "1" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "" "Fatty acid biosynthesis" "1" "0" "30.6" "23.0" "30.7" "110.6" "50.5" "25.6" "55.4" "33.3" "53.9" "262.4" "372.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "3" "2" "4" "2" "868" "96.0" "6.52" "760.47" "5.80" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "5" "0" "8.9" "10.2" "18.5" "207.6" "42.5" "0.5" "10.6" "21.6" "15.2" "45.4" "50.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "3" "2" "4" "2" "608" "68.4" "7.65" "572.24" "5.77" "2" "2" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "Nonhomologous End-Joining (NHEJ)" "" "1" "0" "43.7" "53.2" "64.8" "154.9" "98.8" "56.7" "97.6" "82.3" "96.9" "273.7" "282.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "12" "2" "4" "2" "243" "27.2" "7.30" "668.01" "5.75" "2" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; Sphingolipid de novo biosynthesis" "Ciliary landscape" "7" "0" "131.7" "115.8" "156.4" "507.6" "236.7" "116.3" "183.4" "131.8" "190.8" "561.5" "635.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15226" "NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2" "5" "3" "4" "3" "690" "77.6" "8.79" "782.67" "5.73" "2" "2" "RNA metabolism OR transcription;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01424, Pf01585" "55922" "ENSG00000186416" "NKRF" "G3V1N1; hsa:55922; O15226; Q4VC41; Q9UJ91" "" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "2" "0" "56.5" "48.7" "51.7" "144.5" "76.4" "51.9" "114.7" "49.4" "53.3" "149.3" "87.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96FZ2" "Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1" "6" "2" "3" "2" "354" "40.5" "8.15" "292.27" "5.73" "1" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02586" "56941" "ENSG00000183624" "HMCES" "A6NJR9; hsa:56941; Q96FZ2; Q96G34; Q9NRP3" "" "" "0" "0" "35.0" "34.3" "52.3" "177.4" "62.8" "38.1" "77.9" "36.1" "42.6" "133.6" "115.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "1" "2" "5" "1" "2542" "269.3" "5.73" "1161.75" "5.71" "2" "1" "stress response" "other cell component" "" "Pf00013, Pf12796" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "0" "19.3" "12.7" "14.8" "42.9" "19.5" "18.6" "30.1" "16.8" "21.7" "57.5" "57.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "4" "2" "4" "2" "623" "69.9" "5.67" "734.81" "5.71" "2" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "0" "6.3" "15.0" "17.9" "88.6" "31.8" "11.1" "22.7" "23.1" "30.8" "60.5" "75.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15654" "Thyroid receptor-interacting protein 6 OS=Homo sapiens OX=9606 GN=TRIP6 PE=1 SV=3" "4" "1" "2" "1" "476" "50.3" "7.37" "469.09" "5.70" "1" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00412" "7205" "ENSG00000087077" "TRIP6" "A4D2E7; F2ZC07; F2ZC08; hsa:7205; O15170; O15275; Q15654; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4" "" "" "0" "0" "65.0" "42.1" "76.5" "137.1" "95.6" "89.9" "115.0" "45.1" "72.0" "109.0" "78.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NW08" "DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2" "1" "1" "3" "1" "1133" "127.7" "8.50" "295.70" "5.69" "1" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "55703" "ENSG00000013503" "POLR3B" "A8K6H0; B3KV73; F5H1E6; hsa:55703; Q9NW08; Q9NW59" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "997.4" "678.8" "510.7" "187.7" "143.5" "110.6" "327.3" "28.9" "98.1" "187.7" "96.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UGN5" "Poly [ADP-ribose] polymerase 2 OS=Homo sapiens OX=9606 GN=PARP2 PE=1 SV=2" "5" "3" "4" "3" "583" "66.2" "8.88" "772.37" "5.69" "2" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00644, Pf02877, Pf05406" "10038" "ENSG00000129484" "PARP2" "hsa:10038; Q8TEU4; Q9NUV2; Q9UGN5; Q9UMR4; Q9Y6C8" "Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); POLB-Dependent Long Patch Base Excision Repair" "NAD+ biosynthetic pathways; Base excision repair; Peroxiredoxin 2 induced ovarian failure; DNA repair pathways, full network; 10q11.21q11.23 copy number variation syndrome" "10" "0" "139.4" "120.5" "175.8" "389.2" "209.5" "159.0" "271.2" "147.3" "355.8" "1156.2" "763.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "3" "2" "5" "1" "767" "86.4" "6.89" "1088.72" "5.69" "2" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "" "Sterol regulatory element-binding proteins (SREBP) signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TCJ2" "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens OX=9606 GN=STT3B PE=1 SV=1" "4" "3" "5" "3" "826" "93.6" "8.91" "871.83" "5.68" "3" "2" "protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02516" "201595" "ENSG00000163527" "STT3B" "hsa:201595; Q8TCJ2; Q96JZ4; Q96KY7" "" "N-glycan biosynthesis" "1" "0" "219.9" "217.4" "267.7" "672.3" "343.3" "207.2" "426.7" "231.8" "305.1" "811.3" "746.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "3" "2" "4" "2" "902" "101.4" "8.40" "648.25" "5.68" "2" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "66.0" "57.4" "70.3" "144.3" "88.5" "70.7" "114.8" "43.7" "67.1" "182.7" "147.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WXC6" "COP9 signalosome complex subunit 9 OS=Homo sapiens OX=9606 GN=COPS9 PE=1 SV=3" "35" "1" "2" "1" "57" "6.2" "3.83" "452.10" "5.68" "1" "1" "other biological processes" "nucleus;other cell component" "" "Pf15004" "150678" "ENSG00000172428" "COPS9" "hsa:150678; Q8N110; Q8WXC6" "" "2q37 copy number variation syndrome" "1" "0" "2.5" "6.8" "2.0" "16.6" "11.8" "6.9" "35.6" "21.8" "19.2" "102.1" "164.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75531" "Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1" "25" "2" "4" "2" "89" "10.1" "6.09" "780.65" "5.67" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02961" "8815" "ENSG00000175334" "BANF1" "hsa:8815; O60558; O75531; Q6FGG7" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy; Progeria-associated lipodystrophy" "11" "0" "101.8" "114.3" "159.0" "1147.0" "282.2" "78.1" "222.4" "130.3" "139.1" "483.6" "341.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "8" "2" "3" "2" "203" "23.8" "9.26" "394.66" "5.67" "1" "2" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "134.4" "108.6" "150.3" "441.6" "205.1" "114.4" "251.6" "134.1" "231.7" "1247.8" "1470.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6WCQ1" "Myosin phosphatase Rho-interacting protein OS=Homo sapiens OX=9606 GN=MPRIP PE=1 SV=3" "2" "2" "3" "2" "1025" "116.5" "6.21" "364.58" "5.67" "1" "2" "" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00169" "23164" "ENSG00000133030" "MPRIP" "hsa:23164; Q3KQZ5; Q5FB94; Q6DHW2; Q6WCQ1; Q7Z5Y2; Q8N390; Q96G40" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "61.3" "45.8" "62.5" "163.9" "75.2" "50.3" "71.4" "43.9" "66.3" "195.8" "204.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00013" "55 kDa erythrocyte membrane protein OS=Homo sapiens OX=9606 GN=MPP1 PE=1 SV=2" "5" "2" "4" "2" "466" "52.3" "7.37" "579.47" "5.67" "2" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;kinase activity" "Pf00018, Pf00595, Pf00625" "4354" "ENSG00000130830" "MPP1" "B4DZV5; G3XAI1; hsa:4354; Q00013; Q2TSB6; Q5J7V5" "Sensory processing of sound by outer hair cells of the cochlea" "MECP2 and associated Rett syndrome" "2" "0" "19.9" "17.4" "26.9" "66.7" "33.0" "17.2" "41.7" "25.6" "37.6" "94.0" "97.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "8" "2" "3" "2" "407" "42.1" "5.07" "480.87" "5.61" "1" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Ub-specific processing proteases; UCH proteinases" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "4" "0" "57.4" "55.4" "84.8" "389.6" "117.8" "53.1" "109.4" "62.1" "74.9" "227.5" "160.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "20" "1" "2" "1" "79" "9.7" "8.94" "589.47" "5.60" "1" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "Small cell lung cancer" "3" "0" "76.6" "69.9" "100.6" "535.0" "136.4" "65.1" "178.6" "85.3" "150.2" "1004.4" "1025.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NFY9" "Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2" "5" "3" "4" "3" "601" "68.8" "6.29" "816.27" "5.59" "2" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "84541" "ENSG00000163376" "KBTBD8" "B4DTW6; hsa:84541; Q8NFY9; Q96JI5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "47.9" "41.6" "63.9" "140.5" "93.3" "60.0" "67.4" "93.4" "131.7" "427.0" "308.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "5" "2" "4" "1" "344" "39.6" "11.43" "605.08" "5.59" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "7" "0" "167.2" "163.1" "202.1" "573.6" "284.9" "142.2" "297.8" "186.4" "137.5" "311.2" "202.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12830" "Nucleosome-remodeling factor subunit BPTF OS=Homo sapiens OX=9606 GN=BPTF PE=1 SV=3" "1" "2" "4" "2" "3046" "338.1" "6.54" "646.69" "5.58" "2" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf15613" "2186" "ENSG00000171634" "BPTF" "hsa:2186; Q12830; Q6NX67; Q7Z7D6; Q9UIG2" "" "Endoderm differentiation; 16p11.2 proximal deletion syndrome" "2" "0" "68.8" "73.4" "102.7" "362.0" "167.8" "70.5" "200.5" "100.9" "112.4" "405.9" "335.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A4D1P6" "WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2" "3" "2" "3" "2" "747" "83.3" "6.58" "248.31" "5.58" "1" "2" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00400" "29062" "ENSG00000105875" "WDR91" "A4D1P6; A6NK54; C9JMI4; hsa:29062; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062; Q9H9B6; Q9NVG7; Q9NZY6" "CDC42 GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "2" "2" "3" "2" "819" "93.4" "5.72" "237.65" "5.57" "1" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "84.3" "68.5" "92.1" "273.6" "135.7" "75.5" "144.2" "85.5" "88.4" "270.8" "184.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "1" "2" "4" "2" "2054" "233.0" "6.30" "833.71" "5.54" "2" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf01576, Pf17820" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "32" "2" "2" "2" "103" "11.6" "5.27" "" "5.54" "" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "59.8" "58.4" "91.0" "279.3" "133.6" "57.8" "110.2" "69.5" "80.6" "286.6" "346.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "41" "5" "9" "5" "110" "11.3" "6.54" "2163.03" "5.53" "5" "2" "protein metabolism;stress response;transport;other biological processes" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "Antimicrobial peptides" "" "1" "0" "4076.6" "2129.6" "979.6" "2257.4" "1015.0" "665.2" "997.2" "1140.3" "962.8" "1578.5" "1102.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "25" "1" "1" "1" "102" "11.2" "9.32" "" "5.53" "" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "32.3" "25.0" "48.3" "90.6" "51.6" "38.7" "67.6" "28.4" "46.8" "74.4" "39.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60981" "Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3" "15" "2" "4" "1" "165" "18.5" "7.85" "1028.85" "5.53" "2" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00241" "11034" "ENSG00000125868" "DSTN" "B2R6N2; B4DYA6; hsa:11034; P18282; P60981; Q5W166; Q6IAW2" "" "Androgen receptor signaling pathway" "1" "0" "2.7" "0.0" "4.1" "56.5" "10.1" "1.9" "8.3" "9.3" "2.9" "15.5" "10.7" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "4" "1" "2" "1" "421" "46.6" "8.37" "598.76" "5.53" "1" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "27.3" "25.2" "33.5" "148.0" "56.2" "26.2" "39.9" "29.5" "27.9" "68.3" "64.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99538" "Legumain OS=Homo sapiens OX=9606 GN=LGMN PE=1 SV=1" "6" "1" "1" "1" "433" "49.4" "6.55" "" "5.51" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01650" "5641" "ENSG00000100600" "LGMN" "hsa:5641; O00123; Q86TV2; Q86TV3; Q99538; Q9BTY1" "MHC class II antigen presentation; Trafficking and processing of endosomal TLR; Vitamin D (calciferol) metabolism" "Involvement of d-secretase in neurodegenerative diseases" "4" "0" "10.6" "12.3" "17.7" "53.7" "21.3" "14.6" "27.1" "17.8" "64.1" "186.0" "127.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P16615" "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2A2 PE=1 SV=1" "2" "1" "2" "1" "1042" "114.7" "5.34" "545.56" "5.51" "1" "1" "cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf08282, Pf13246" "488" "ENSG00000174437" "ATP2A2" "A6NDN7; B4DF05; hsa:488; P16614; P16615; Q86VJ2" "Ion homeostasis; Ion transport by P-type ATPases; Pre-NOTCH Processing in Golgi; Reduction of cytosolic Ca++ levels" "Alzheimer's disease and miRNA effects; Arrhythmogenic right ventricular cardiomyopathy; Endothelin pathways; Myometrial relaxation and contraction pathways; Alzheimer's disease; Calcium regulation in cardiac cells" "10" "0" "98.2" "83.6" "94.0" "228.3" "109.5" "74.0" "116.4" "77.2" "71.6" "199.8" "204.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28370" "Probable global transcription activator SNF2L1 OS=Homo sapiens OX=9606 GN=SMARCA1 PE=1 SV=2" "2" "2" "4" "2" "1054" "122.5" "8.09" "688.58" "5.50" "2" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "6594" "ENSG00000102038" "SMARCA1" "hsa:6594; P28370; Q5JV41; Q5JV42" "" "Nuclear receptors meta-pathway; Rett syndrome causing genes" "2" "0" "64.6" "54.8" "65.6" "175.7" "96.5" "64.0" "92.4" "54.6" "79.1" "413.1" "487.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "12" "1" "2" "1" "124" "13.7" "8.28" "762.35" "5.50" "1" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "36.0" "44.9" "50.6" "177.8" "69.8" "41.7" "65.1" "34.3" "47.1" "126.2" "96.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A0A0B4J2D5" "Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=1 SV=1" "12" "2" "2" "2" "268" "28.1" "8.27" "272.56" "5.49" "1" "1" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "" "Gastric cancer network 1" "1" "0" "36.8" "43.1" "77.9" "396.6" "107.3" "23.5" "79.3" "56.0" "60.7" "337.0" "383.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "7" "2" "4" "2" "246" "29.1" "9.72" "618.16" "5.49" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "8" "0" "201.5" "182.4" "249.4" "545.1" "293.5" "191.6" "303.3" "156.5" "211.3" "570.8" "484.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4H2" "Insulin receptor substrate 2 OS=Homo sapiens OX=9606 GN=IRS2 PE=1 SV=2" "2" "2" "4" "2" "1338" "137.2" "8.65" "605.72" "5.48" "2" "2" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf02174" "8660" "ENSG00000185950" "IRS2" "hsa:8660; Q96RR2; Q9BZG0; Q9Y4H2; Q9Y6I5" "Growth hormone receptor signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by Leptin; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation" "Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways" "38" "0" "33.5" "39.6" "46.4" "134.1" "61.5" "45.5" "85.7" "89.9" "174.1" "475.5" "420.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "2" "2" "4" "2" "1443" "160.8" "6.40" "537.60" "5.48" "2" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "7" "0" "9.5" "9.2" "11.3" "34.3" "16.4" "11.6" "14.1" "11.0" "11.3" "39.1" "36.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14136" "Glial fibrillary acidic protein OS=Homo sapiens OX=9606 GN=GFAP PE=1 SV=1" "6" "2" "3" "1" "432" "49.9" "5.52" "402.41" "5.46" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00038, Pf04732" "2670" "ENSG00000131095" "GFAP" "A7REI1; B2RD44; D3DX59; E9PAX3; hsa:2670; P14136; Q53H98; Q5D055; Q6ZQS3; Q7Z5J6; Q7Z5J7; Q96KS4; Q96P18; Q9UFD0" "Nuclear signaling by ERBB4; Chaperone Mediated Autophagy" "Neural crest differentiation; Spinal cord injury; Neuroinflammation and glutamatergic signaling" "5" "0" "9.4" "8.3" "13.8" "21.2" "15.7" "10.7" "239.7" "113.8" "4.8" "39.3" "46.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "11" "2" "4" "2" "188" "21.0" "5.14" "491.07" "5.46" "2" "2" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "Glutathione synthesis and recycling" "" "1" "0" "78.7" "65.9" "89.7" "328.8" "128.3" "52.2" "98.8" "70.2" "123.1" "309.7" "271.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "4" "1" "2" "1" "362" "41.4" "9.28" "459.21" "5.46" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "HATs acetylate histones" "Pathways affected in adenoid cystic carcinoma" "2" "0" "18.1" "20.1" "28.7" "85.4" "41.1" "22.3" "42.3" "30.5" "37.9" "225.3" "233.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "3" "2" "4" "2" "727" "79.4" "6.23" "567.15" "5.46" "2" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "54.6" "49.4" "74.9" "224.0" "84.0" "42.8" "74.4" "62.9" "59.4" "171.7" "227.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49916" "DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2" "2" "2" "4" "2" "1009" "112.8" "9.01" "597.38" "5.45" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00645, Pf01068, Pf04675, Pf04679, Pf16759" "3980" "ENSG00000005156" "LIG3" "E5KLB5; E5KLB6; hsa:3980; P49916; Q16714; Q6NVK3" "HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 17q12 copy number variation syndrome" "9" "0" "75.3" "80.1" "99.4" "253.3" "116.2" "69.1" "127.7" "92.9" "110.0" "399.0" "540.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "5" "2" "3" "1" "372" "42.8" "8.79" "388.97" "5.44" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H8E8" "Cysteine-rich protein 2-binding protein OS=Homo sapiens OX=9606 GN=KAT14 PE=1 SV=3" "2" "1" "2" "1" "782" "88.8" "6.57" "560.98" "5.42" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13673" "57325" "ENSG00000149474" "KAT14" "A2A2I5; hsa:57325; Q96GW6; Q96IH3; Q9H8E8; Q9HBF0; Q9UIY5" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P05556" "Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 PE=1 SV=2" "2" "1" "2" "1" "798" "88.4" "5.39" "579.43" "5.40" "1" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00362, Pf07965, Pf07974, Pf08725, Pf17205, Pf18372" "3688" "ENSG00000150093" "ITGB1" "A8K6N2; D3DRX9; D3DRY3; D3DRY4; D3DRY5; hsa:3688; P05556; P78466; P78467; Q13089; Q13090; Q13091; Q13212; Q14622; Q14647; Q29RW2; Q7Z3V1; Q8WUM6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Potential therapeutics for SARS; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases Activate Formins; HCMV Early Events; RAC2 GTPase cycle; RAC3 GTPase cycle; Integrin cell surface interactions; ECM proteoglycans; GPER1 signaling; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; Signal transduction by L1; Syndecan interactions; Other semaphorin interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions; Platelet Adhesion to exposed collagen; Molecules associated with elastic fibres; TGF-beta receptor signaling activates SMADs; Fibronectin matrix formation; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; MET interacts with TNS proteins" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Cells and molecules involved in local acute inflammatory response ; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Small cell lung cancer; Gastrin signaling pathway; Genes controlling nephrogenesis; Development of ureteric collection system; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; 11p11.2 copy number variation syndrome ; A network map of Macrophage-stimulating protein (MSP) signaling" "54" "0" "30.4" "28.8" "38.8" "143.6" "57.2" "30.5" "41.0" "34.6" "47.5" "98.1" "75.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3D7" "Mitochondrial import inner membrane translocase subunit TIM16 OS=Homo sapiens OX=9606 GN=PAM16 PE=1 SV=2" "16" "2" "4" "2" "125" "13.8" "9.70" "566.79" "5.40" "2" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;other cell component" "" "Pf03656" "51025" "ENSG00000217930; ENSG00000282228" "PAM16" "hsa:51025; Q6I9Z3; Q9H5X3; Q9Y3D7" "Mitochondrial protein import" "" "1" "0" "83.1" "71.9" "96.7" "218.4" "111.7" "73.1" "126.0" "67.7" "77.3" "187.3" "141.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "2" "1" "4" "1" "751" "83.4" "7.01" "673.72" "5.37" "1" "1" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "Mitochondrial translation elongation" "" "1" "0" "7.6" "10.5" "12.5" "48.0" "21.4" "3.5" "6.5" "6.0" "10.4" "14.2" "23.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "3" "2" "4" "1" "704" "80.1" "8.21" "554.94" "5.37" "2" "2" "other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183, Pf02518" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "Respiratory electron transport" "TNF-alpha signaling pathway; Clock-controlled autophagy in bone metabolism" "3" "0" "32.2" "27.3" "55.0" "485.2" "93.5" "0.9" "53.2" "53.4" "41.9" "162.9" "239.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NNW5" "WD repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "2" "2" "4" "2" "1121" "121.6" "6.87" "583.58" "5.36" "2" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "" "5" "0" "6.0" "7.7" "7.8" "45.6" "13.6" "5.5" "15.3" "7.7" "6.7" "273.9" "243.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86TS9" "39S ribosomal protein L52, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL52 PE=1 SV=2" "22" "2" "3" "2" "123" "13.7" "10.26" "933.72" "5.35" "2" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf18699" "122704" "ENSG00000172590" "MRPL52" "A6NMQ8; A8MXK5; A8MYI6; G3XCN9; hsa:122704; Q6NVH8; Q86TS9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "185.9" "152.9" "231.7" "412.3" "278.7" "224.6" "299.3" "118.9" "233.4" "314.0" "174.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "9" "3" "5" "3" "337" "37.5" "6.81" "887.73" "5.34" "3" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "9" "0" "35.0" "42.4" "62.3" "394.0" "120.3" "12.2" "18.8" "47.9" "37.3" "74.1" "59.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "4" "1" "7" "1" "426" "46.0" "8.53" "590.97" "5.34" "1" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "Photodynamic therapy-induced HIF-1 survival signaling; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQ66" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 OS=Homo sapiens OX=9606 GN=PLCB1 PE=1 SV=1" "2" "2" "3" "2" "1216" "138.5" "6.23" "360.70" "5.34" "1" "2" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00387, Pf00388, Pf06631, Pf08703, Pf09279, Pf17787" "23236" "ENSG00000182621" "PLCB1" "D3DW12; D3DW13; hsa:23236; O60325; Q17RQ6; Q5TFF7; Q5TGC9; Q8IV93; Q9BQW2; Q9H4H2; Q9H8H5; Q9NQ65; Q9NQ66; Q9NQH9; Q9NTH4; Q9UJP6; Q9UM26" "G alpha (q) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; Synthesis of IP3 and IP4 in the cytosol; PLC beta mediated events; Acetylcholine regulates insulin secretion" "AMP-activated protein kinase signaling; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; S1P receptor signal transduction; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; Fragile X syndrome; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; Alzheimer's disease" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BYI3" "Hyccin OS=Homo sapiens OX=9606 GN=FAM126A PE=1 SV=2" "4" "2" "4" "2" "521" "57.6" "8.16" "496.08" "5.33" "2" "2" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09790" "84668" "ENSG00000122591" "HYCC1" "A0A024RA06; A4D145; B8ZZJ1; hsa:84668; Q6N010; Q75MR4; Q7LDZ4; Q96MX1; Q96NQ6; Q9BYI3" "" "" "0" "0" "16.5" "10.2" "15.7" "47.7" "24.1" "15.0" "36.9" "16.6" "37.2" "213.6" "159.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92522" "Histone H1.10 OS=Homo sapiens OX=9606 GN=H1-10 PE=1 SV=1" "7" "1" "2" "1" "213" "22.5" "10.76" "552.98" "5.32" "1" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "8971" "ENSG00000184897" "H1-10" "hsa:8971; Q92522" "" "" "0" "0" "67.4" "46.7" "62.9" "100.9" "76.3" "61.9" "86.8" "44.0" "45.2" "91.0" "90.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NR28" "Diablo homolog, mitochondrial OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "13" "2" "3" "2" "239" "27.1" "5.90" "850.03" "5.32" "2" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "10" "0" "16.0" "12.8" "17.1" "47.4" "18.5" "11.5" "18.8" "11.0" "13.0" "30.4" "19.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15738" "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=NSDHL PE=1 SV=2" "6" "1" "1" "1" "373" "41.9" "8.06" "" "5.32" "" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01073" "50814" "ENSG00000147383" "NSDHL" "D3DWT6; hsa:50814; O00344; Q15738" "Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96A33" "Coiled-coil domain-containing protein 47 OS=Homo sapiens OX=9606 GN=CCDC47 PE=1 SV=1" "6" "2" "3" "2" "483" "55.8" "4.87" "267.60" "5.32" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity;other molecular function" "Pf07946" "57003" "ENSG00000108588" "CCDC47" "B2RAS8; D3DU20; hsa:57003; Q96A33; Q96D00; Q96JZ7; Q9H3E4; Q9NRG3" "" "" "0" "0" "56.8" "47.7" "74.8" "170.4" "90.8" "64.9" "87.7" "60.8" "80.7" "312.4" "273.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "4" "2" "4" "2" "522" "56.2" "8.50" "615.30" "5.32" "2" "2" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "10" "0" "63.3" "76.9" "90.4" "325.1" "142.4" "54.0" "126.0" "104.6" "85.9" "329.4" "171.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "7" "1" "2" "1" "252" "25.4" "9.88" "576.00" "5.31" "1" "1" "RNA metabolism OR transcription;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "7.2" "10.3" "7.4" "22.3" "9.9" "5.6" "8.7" "6.7" "8.6" "21.4" "33.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T280" "Putative methyltransferase C9orf114 OS=Homo sapiens OX=9606 GN=SPOUT1 PE=1 SV=3" "7" "2" "4" "2" "376" "42.0" "7.43" "691.50" "5.31" "2" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "nucleic acid binding activity;other molecular function" "Pf02598" "51490" "ENSG00000198917" "SPOUT1" "hsa:51490; Q0D2P6; Q5T280; Q6P469; Q6PGP9; Q6PIJ1; Q6PJV9" "" "" "0" "0" "42.7" "44.1" "49.6" "103.9" "64.7" "52.1" "67.9" "44.9" "84.8" "237.6" "171.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "11" "2" "4" "1" "201" "23.0" "8.29" "520.10" "5.31" "2" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IV48" "3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3" "5" "2" "5" "2" "349" "40.0" "6.70" "915.18" "5.30" "2" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00929, Pf02037" "90459" "ENSG00000104626" "ERI1" "A8K4U7; hsa:90459; Q8IV48; Q9NSX3" "Major pathway of rRNA processing in the nucleolus and cytosol" "exRNA mechanism of action and biogenesis; 8p23.1 copy number variation syndrome" "3" "0" "87.5" "81.6" "127.3" "300.4" "161.2" "95.9" "173.8" "111.3" "311.7" "2844.2" "2514.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "5" "2" "6" "2" "350" "41.2" "8.56" "582.52" "5.29" "2" "2" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "19" "0" "152.8" "147.6" "195.2" "553.8" "244.9" "112.4" "268.1" "180.0" "172.4" "700.9" "1372.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IZH2" "5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1" "1" "2" "3" "2" "1706" "194.0" "7.21" "252.64" "5.28" "1" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846, Pf18129, Pf18332, Pf18334" "54464" "ENSG00000114127" "XRN1" "hsa:54464; Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8IZH2; Q8N8U4; Q9UF39" "mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "miRNA degrading enzymes" "4" "0" "54.6" "50.5" "76.3" "186.4" "87.5" "64.3" "115.1" "63.4" "69.5" "279.8" "246.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "31" "3" "5" "3" "123" "13.9" "5.52" "896.27" "5.27" "3" "2" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "97.8" "110.9" "189.5" "1251.5" "358.9" "21.4" "103.3" "152.1" "93.9" "232.7" "241.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "4" "2" "4" "2" "639" "71.4" "6.40" "536.37" "5.27" "2" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00018, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Nephrin family interactions" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "5" "0" "46.2" "38.0" "44.6" "123.4" "71.7" "42.5" "84.2" "38.0" "46.1" "188.8" "177.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "7" "2" "4" "2" "258" "27.5" "6.05" "566.87" "5.27" "2" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate pathway" "Pentose phosphate metabolism" "2" "0" "57.9" "50.9" "94.4" "456.1" "172.7" "54.1" "115.3" "82.9" "85.3" "195.5" "139.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43824" "Putative GTP-binding protein 6 OS=Homo sapiens OX=9606 GN=GTPBP6 PE=2 SV=4" "3" "1" "2" "1" "516" "56.9" "9.42" "554.77" "5.27" "1" "1" "" "other cell component" "translation activity;other molecular function" "Pf01926, Pf13167, Pf16360" "8225" "ENSG00000178605" "GTPBP6" "H0Y2S1; hsa:8225; O43824; Q53F77; Q5HYX8" "" "" "0" "0" "6.0" "8.8" "8.8" "19.2" "10.3" "7.4" "11.2" "6.9" "7.5" "23.3" "12.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86TJ2" "Transcriptional adapter 2-beta OS=Homo sapiens OX=9606 GN=TADA2B PE=1 SV=2" "5" "2" "4" "2" "420" "48.4" "7.83" "638.83" "5.27" "2" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249" "93624" "ENSG00000173011" "TADA2B" "A0AUJ8; A4QMR7; B3KSN0; B3KU86; hsa:93624; Q6MZG9; Q86TJ2" "Ub-specific processing proteases; HATs acetylate histones" "" "2" "0" "6.0" "8.1" "18.6" "45.7" "16.7" "17.6" "27.1" "15.7" "22.1" "96.0" "97.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00401" "Neural Wiskott-Aldrich syndrome protein OS=Homo sapiens OX=9606 GN=WASL PE=1 SV=2" "5" "1" "1" "1" "505" "54.8" "7.93" "" "5.27" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf00568, Pf00786, Pf02205" "8976" "ENSG00000106299" "WASL" "A1JUI9; hsa:8976; O00401; Q7Z746" "Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling" "Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway" "17" "0" "7.2" "2.6" "9.5" "20.6" "9.3" "4.9" "10.8" "3.6" "8.4" "51.1" "43.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49755" "Transmembrane emp24 domain-containing protein 10 OS=Homo sapiens OX=9606 GN=TMED10 PE=1 SV=2" "10" "2" "4" "2" "219" "25.0" "7.44" "580.63" "5.26" "2" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf01105" "10972" "ENSG00000170348" "TMED10" "B2R605; hsa:10972; P49755; Q15602; Q16536; Q86TC2; Q86TS5" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; Cargo concentration in the ER" "mRNA processing" "5" "0" "127.8" "122.5" "164.3" "977.3" "305.0" "50.4" "153.7" "137.7" "155.6" "378.9" "478.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51571" "Translocon-associated protein subunit delta OS=Homo sapiens OX=9606 GN=SSR4 PE=1 SV=1" "7" "1" "2" "1" "173" "19.0" "6.15" "563.76" "5.26" "1" "1" "" "other membranes;ER/Golgi;other cell component" "" "Pf05404" "6748" "ENSG00000180879" "SSR4" "A8K378; hsa:6748; P51571; Q53XY1" "SRP-dependent cotranslational protein targeting to membrane" "VEGFA-VEGFR2 signaling" "2" "0" "177.6" "153.3" "226.6" "870.6" "341.1" "168.8" "285.3" "195.8" "164.6" "445.6" "364.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WYQ5" "Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1" "3" "2" "4" "2" "773" "86.0" "5.95" "500.35" "5.25" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "54487" "ENSG00000128191" "DGCR8" "B2R8G1; hsa:54487; Q6DCB2; Q6MZE9; Q6Y2L0; Q8WYQ5; Q96G39; Q96GP8; Q9H6L8; Q9H6T7; Q9NRW2" "Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome" "6" "0" "20.1" "26.3" "22.6" "60.0" "34.3" "13.5" "37.7" "21.3" "27.6" "101.5" "69.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "10" "3" "5" "3" "261" "28.0" "8.05" "937.36" "5.23" "3" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "2" "0" "257.5" "266.1" "400.1" "899.0" "474.8" "276.4" "1367.2" "298.4" "279.6" "1150.4" "478.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EY5" "Multivesicular body subunit 12A OS=Homo sapiens OX=9606 GN=MVB12A PE=1 SV=1" "7" "1" "2" "1" "273" "28.8" "8.91" "481.85" "5.23" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10240" "93343" "ENSG00000141971" "MVB12A" "hsa:93343; Q96EY5; Q96I18" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events" "7q11.23 copy number variation syndrome" "6" "0" "29.0" "23.4" "32.6" "63.6" "44.3" "37.0" "53.6" "45.7" "77.5" "202.2" "226.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKS6" "Protein kinase C and casein kinase substrate in neurons protein 3 OS=Homo sapiens OX=9606 GN=PACSIN3 PE=1 SV=2" "6" "2" "3" "2" "424" "48.5" "6.18" "746.23" "5.22" "2" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "29763" "ENSG00000165912" "PACSIN3" "A6NH84; hsa:29763; Q9H331; Q9NWV9; Q9UKS6" "Clathrin-mediated endocytosis" "" "1" "0" "115.7" "96.8" "104.4" "212.7" "136.2" "102.3" "221.1" "68.5" "138.0" "452.9" "390.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16637" "Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN1 PE=1 SV=1" "5" "2" "5" "2" "294" "31.8" "6.55" "806.05" "5.21" "2" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06003" "6606; 6607" "ENSG00000172062; ENSG00000205571; ENSG00000273772; ENSG00000275349; ENSG00000277773" "SMN1; SMN2" "A8K0V4; hsa:6606; hsa:6607; Q13119; Q16637; Q549U5; Q96J51" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "11p11.2 copy number variation syndrome" "3" "0" "393.9" "375.6" "481.5" "1204.5" "593.8" "336.5" "706.9" "448.1" "392.8" "963.0" "727.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "9" "2" "4" "2" "238" "26.7" "7.24" "728.20" "5.19" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "mRNA Splicing - Major Pathway" "" "1" "0" "79.2" "58.8" "81.3" "168.4" "112.5" "70.4" "103.6" "57.9" "126.8" "306.8" "361.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "4" "1" "2" "1" "475" "52.8" "5.97" "730.39" "5.18" "1" "1" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "Glutathione synthesis and recycling; Paracetamol ADME" "" "2" "0" "15.0" "17.2" "29.2" "190.8" "52.0" "13.4" "17.4" "19.1" "13.2" "29.6" "23.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=4" "10" "1" "1" "1" "215" "24.6" "6.92" "" "5.17" "" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "13.9" "8.4" "16.9" "64.4" "28.0" "16.6" "21.5" "15.0" "11.2" "30.7" "27.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "1" "2" "4" "2" "1226" "136.0" "8.65" "507.67" "5.17" "2" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "Measles virus infection; Cytosolic DNA-sensing pathway" "5" "0" "37.3" "38.6" "50.0" "192.3" "92.2" "36.8" "112.0" "42.0" "49.5" "205.3" "209.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "4" "2" "4" "2" "579" "65.5" "7.06" "562.98" "5.16" "2" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "5" "0" "33.2" "28.7" "44.8" "139.9" "65.1" "36.7" "57.4" "42.7" "62.8" "338.0" "329.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92759" "General transcription factor IIH subunit 4 OS=Homo sapiens OX=9606 GN=GTF2H4 PE=1 SV=1" "6" "2" "4" "2" "462" "52.2" "9.04" "569.56" "5.15" "2" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03849, Pf18307" "2968" "ENSG00000213780; ENSG00000221974; ENSG00000226384; ENSG00000233149; ENSG00000234370; ENSG00000236895" "GTF2H4" "B4DTJ5; hsa:2968; Q76KU4; Q92759" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 11p11.2 copy number variation syndrome" "34" "0" "97.6" "87.3" "94.6" "212.3" "137.3" "115.0" "198.0" "318.7" "954.8" "1446.8" "1024.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14241" "Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=2" "2" "2" "4" "2" "798" "89.9" "9.57" "570.12" "5.15" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06881, Pf08711" "6924" "ENSG00000011007" "ELOA" "B2R7Q8; hsa:6924; Q14241; Q8IXH1" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "VEGFA-VEGFR2 signaling" "12" "0" "150.8" "113.6" "148.8" "344.1" "200.5" "128.4" "248.4" "135.2" "345.9" "1146.6" "1081.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EI5" "Transcription elongation factor A protein-like 4 OS=Homo sapiens OX=9606 GN=TCEAL4 PE=1 SV=2" "9" "2" "4" "2" "215" "24.6" "5.20" "651.01" "5.14" "2" "2" "" "nucleus" "" "Pf04538" "79921" "ENSG00000133142" "TCEAL4" "hsa:79921; Q8WY12; Q96EI5; Q9H2H1; Q9H775" "" "" "0" "0" "215.5" "174.4" "278.6" "611.4" "339.5" "172.9" "286.9" "186.6" "248.0" "382.6" "286.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "5" "3" "5" "3" "521" "56.7" "7.99" "886.33" "5.14" "3" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; CDC42 GTPase cycle" "IL-18 signaling pathway" "4" "0" "228.2" "185.2" "263.6" "570.5" "303.6" "204.6" "388.2" "222.5" "287.5" "853.8" "960.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96ES7" "SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1" "4" "1" "2" "1" "293" "33.2" "8.10" "530.90" "5.12" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07039" "112869" "ENSG00000176476" "SGF29" "hsa:112869; Q96ES7; Q96MF5" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "" "2" "0" "8.7" "12.1" "14.3" "25.7" "15.9" "11.4" "21.5" "13.9" "27.4" "141.4" "128.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "1" "4" "8" "4" "2363" "267.1" "5.02" "1662.75" "5.11" "4" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "" "29" "0" "115.9" "106.6" "174.5" "831.5" "258.7" "100.5" "314.9" "147.3" "183.3" "907.1" "882.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "4" "2" "3" "2" "480" "50.4" "9.63" "321.13" "5.10" "1" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "mRNA Splicing - Major Pathway" "" "1" "0" "155.6" "108.6" "150.3" "299.9" "178.1" "129.9" "226.2" "113.3" "136.5" "364.3" "346.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06587" "E3 ubiquitin-protein ligase RING1 OS=Homo sapiens OX=9606 GN=RING1 PE=1 SV=2" "3" "1" "2" "1" "406" "42.4" "5.62" "506.61" "5.08" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00097, Pf16207" "6015" "ENSG00000204227; ENSG00000206287; ENSG00000226788; ENSG00000228520; ENSG00000231115; ENSG00000235107" "RING1" "A8JZZ0; hsa:6015; Q06587; Q5JP96; Q5SQW2; Q86V19" "Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "Pleural mesothelioma; Notch signaling pathway" "11" "0" "57.6" "55.1" "83.0" "185.4" "106.7" "56.7" "135.4" "62.4" "79.1" "185.1" "157.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "2" "2" "4" "2" "959" "106.4" "6.39" "645.37" "5.06" "2" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "" "" "0" "0" "8.7" "8.1" "9.4" "77.9" "26.3" "4.4" "10.5" "13.0" "10.9" "50.1" "77.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRX8" "Peroxiredoxin-like 2A OS=Homo sapiens OX=9606 GN=PRXL2A PE=1 SV=3" "5" "1" "4" "1" "229" "25.7" "8.84" "557.07" "5.06" "1" "1" "other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf13911" "84293" "ENSG00000122378" "PRXL2A" "B2RD81; hsa:84293; Q6UW08; Q8N2K3; Q8NBK9; Q96JR0; Q9BRX8" "" "" "0" "0" "14.7" "13.7" "22.7" "69.3" "33.0" "17.2" "25.8" "19.4" "21.4" "69.7" "46.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "7" "1" "2" "1" "170" "18.7" "5.03" "491.18" "5.05" "1" "1" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "25.9" "23.8" "48.9" "386.7" "107.4" "34.3" "52.3" "38.5" "40.7" "106.4" "93.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "4" "1" "2" "1" "417" "46.5" "5.60" "563.26" "5.04" "1" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "10.0" "9.6" "21.8" "46.9" "26.0" "23.5" "31.0" "17.3" "29.4" "154.8" "146.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "7" "1" "1" "1" "312" "35.1" "6.13" "" "5.04" "" "1" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "hsa:8566; O00764; Q7Z2Y0; Q9BS02" "Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate" "" "2" "0" "10.4" "10.8" "12.7" "63.8" "20.7" "11.8" "16.7" "11.2" "13.7" "26.9" "32.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "4" "2" "4" "2" "414" "46.6" "7.01" "582.03" "5.02" "2" "2" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Neutrophil degranulation; Peroxisomal protein import; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "8" "0" "48.3" "55.5" "85.1" "862.7" "155.4" "0.0" "63.4" "81.5" "66.9" "150.0" "176.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T1J5" "Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD2P9 PE=5 SV=1" "19" "1" "1" "1" "151" "15.5" "9.89" "" "5.02" "" "1" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "" "" "" "CHCHD2P9" "Q5T1J5" "" "" "0" "0" "9.5" "11.3" "9.7" "19.5" "11.1" "9.6" "10.2" "7.8" "8.5" "17.6" "15.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49406" "39S ribosomal protein L19, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "6" "2" "4" "2" "292" "33.5" "9.50" "530.78" "5.00" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Cytoplasmic ribosomal proteins" "4" "0" "94.1" "95.9" "108.3" "296.0" "152.5" "108.9" "154.0" "113.1" "113.2" "331.4" "296.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "4" "1" "2" "1" "364" "40.3" "7.08" "602.95" "5.00" "1" "1" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "Circadian Clock" "" "1" "0" "9.8" "12.0" "17.9" "78.7" "33.1" "13.7" "30.4" "17.0" "22.4" "93.3" "56.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6ZYL4" "General transcription factor IIH subunit 5 OS=Homo sapiens OX=9606 GN=GTF2H5 PE=1 SV=1" "21" "1" "2" "1" "71" "8.0" "4.65" "431.46" "5.00" "1" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf06331" "404672" "ENSG00000272047" "GTF2H5" "hsa:404672; Q0P5V8; Q6ZYL4" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "32" "0" "8.2" "12.2" "12.6" "36.9" "19.9" "6.5" "20.4" "16.9" "52.0" "268.3" "164.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "4" "2" "4" "2" "347" "38.3" "7.64" "789.12" "5.00" "2" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=4" "4" "2" "4" "2" "599" "66.8" "5.64" "659.34" "5.00" "2" "2" "" "" "" "Pf13432" "51434" "" "ANAPC7" "A0A024RBJ3; hsa:51434" "" "" "0" "0" "65.2" "63.5" "70.6" "177.8" "91.1" "64.6" "100.4" "81.7" "78.3" "255.8" "211.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "2" "2" "4" "2" "968" "106.7" "5.53" "561.93" "4.99" "2" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "Cytosolic tRNA aminoacylation" "IL-18 signaling pathway" "2" "0" "138.8" "147.5" "236.6" "2375.4" "449.0" "71.9" "205.8" "205.5" "197.1" "629.0" "588.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NXC2" "Glucose-fructose oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GFOD1 PE=1 SV=1" "6" "1" "1" "1" "390" "43.1" "5.92" "" "4.97" "" "1" "" "non-structural extracellular" "other molecular function" "Pf01408, Pf02894" "54438" "ENSG00000145990" "GFOD1" "A8E4L6; hsa:54438; Q5T058; Q96JD4; Q9H5K2; Q9NXC2" "RHOQ GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P45880" "Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2" "6" "2" "4" "2" "294" "31.5" "7.56" "615.40" "4.97" "2" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01459" "7417" "ENSG00000165637" "VDAC2" "hsa:7417; P45880; Q5VWK1; Q5VWK3; Q6IB40; Q7L3J5; Q9BWK8; Q9Y5I6" "Ub-specific processing proteases; Mitochondrial calcium ion transport" "Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease" "5" "0" "77.4" "76.9" "112.7" "621.2" "168.8" "69.9" "127.6" "112.4" "110.4" "416.0" "606.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "9" "3" "5" "2" "225" "25.5" "9.72" "798.52" "4.95" "3" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA Splicing - Major Pathway" "mRNA processing; Ciliary landscape" "3" "1" "579.0" "470.0" "604.9" "1236.7" "736.7" "515.5" "846.9" "421.0" "621.5" "1396.7" "944.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "2" "1" "2" "1" "788" "86.7" "9.42" "510.53" "4.95" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "O15235" "28S ribosomal protein S12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" "14" "2" "4" "2" "138" "15.2" "10.29" "547.93" "4.93" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00164" "6183" "ENSG00000128626; ENSG00000283018" "MRPS12" "hsa:6183; O15235; Q53X98" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "186.1" "186.2" "220.1" "656.2" "297.4" "196.3" "346.5" "230.3" "233.0" "698.3" "544.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRL2" "Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2" "2" "3" "5" "3" "1556" "178.6" "6.60" "819.74" "4.91" "3" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf10537, Pf15612, Pf15613" "11177" "ENSG00000198604" "BAZ1A" "hsa:11177; Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3" "" "Ectoderm differentiation" "1" "0" "58.6" "52.9" "63.6" "143.6" "85.1" "55.4" "104.6" "52.5" "58.3" "186.6" "188.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "21" "1" "1" "1" "99" "10.9" "9.57" "" "4.91" "" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "16.7" "21.5" "34.0" "75.6" "33.9" "24.6" "39.8" "30.5" "44.4" "104.5" "94.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "10" "1" "2" "1" "191" "21.3" "8.12" "550.64" "4.90" "1" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RHOG GTPase cycle; GPVI-mediated activation cascade; RHO GTPases activate KTN1" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "8" "0" "17.1" "23.5" "25.6" "75.1" "36.2" "20.9" "36.3" "23.2" "32.5" "63.8" "44.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BV81" "ER membrane protein complex subunit 6 OS=Homo sapiens OX=9606 GN=EMC6 PE=1 SV=1" "12" "1" "2" "1" "110" "12.0" "10.07" "568.18" "4.90" "1" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;ER/Golgi" "" "Pf07019" "83460" "ENSG00000127774" "EMC6" "hsa:83460; Q9BV81" "" "" "0" "0" "9.8" "12.0" "11.1" "35.9" "21.5" "13.5" "17.4" "12.8" "16.3" "47.6" "47.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "8" "2" "4" "2" "306" "33.9" "8.59" "556.70" "4.89" "2" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "4.1" "4.1" "6.2" "13.7" "9.1" "3.6" "6.7" "4.8" "14.7" "63.4" "95.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NWW5" "Ceroid-lipofuscinosis neuronal protein 6 OS=Homo sapiens OX=9606 GN=CLN6 PE=1 SV=1" "7" "1" "1" "1" "311" "35.9" "8.87" "" "4.89" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15156" "54982" "ENSG00000128973" "CLN6" "A8K560; B4DDH6; hsa:54982; Q6IAB1; Q96SR0; Q9NWW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "1" "" "False" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=HSPB11 PE=1 SV=1" "10" "1" "2" "1" "144" "16.3" "5.03" "541.27" "4.88" "1" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "6" "0" "24.8" "27.7" "48.8" "298.5" "97.1" "28.7" "39.3" "28.9" "37.1" "68.6" "59.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2Q9" "28S ribosomal protein S28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "10" "2" "4" "2" "187" "20.8" "9.10" "631.77" "4.87" "2" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "182.4" "156.1" "218.9" "661.0" "315.7" "181.3" "339.6" "193.8" "217.7" "534.0" "408.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9ULR3" "Protein phosphatase 1H OS=Homo sapiens OX=9606 GN=PPM1H PE=1 SV=2" "2" "1" "4" "1" "514" "56.4" "6.60" "590.43" "4.87" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00481" "57460" "ENSG00000111110" "PPM1H" "B1Q2A9; B2RXG4; hsa:57460; Q6PI86; Q9ULR3" "" "" "0" "0" "28.9" "27.7" "36.0" "106.9" "50.5" "21.6" "59.1" "38.7" "37.2" "92.2" "68.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12765" "Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2" "3" "1" "2" "1" "414" "46.4" "4.75" "519.91" "4.86" "1" "1" "protein metabolism;transport;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03577" "9805" "ENSG00000136193" "SCRN1" "A8K0E9; B4DHM0; B4DIP5; C9JPG0; hsa:9805; Q12765; Q25QX7; Q8IWD1" "" "" "0" "0" "72.3" "81.6" "118.9" "565.1" "215.1" "57.5" "81.1" "72.3" "63.7" "139.2" "110.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQC6" "Ribosomal protein 63, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL57 PE=1 SV=1" "13" "1" "2" "1" "102" "12.3" "11.44" "507.39" "4.82" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf14978" "78988" "ENSG00000173141" "MRPL57" "A2A332; hsa:78988; Q9BQC6" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "47.1" "52.1" "58.1" "188.1" "97.7" "45.9" "106.7" "59.8" "75.9" "157.0" "126.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPP2" "IQ motif and SEC7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=IQSEC3 PE=2 SV=3" "1" "1" "4" "1" "1182" "127.5" "6.51" "504.04" "4.82" "1" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01369, Pf16453" "440073" "ENSG00000120645; ENSG00000262607" "IQSEC3" "A6NIF2; A6NKV9; hsa:440073; Q8TB43; Q9UPP2" "NPAS4 regulates expression of target genes" "" "1" "0" "90.8" "98.0" "105.4" "238.9" "141.7" "96.8" "225.9" "96.2" "205.3" "1433.4" "2085.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "3" "1" "2" "1" "352" "39.6" "5.19" "577.52" "4.80" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "RND3 GTPase cycle; Striated Muscle Contraction; RHOBTB2 GTPase cycle" "VEGFA-VEGFR2 signaling" "4" "0" "135.9" "111.8" "163.4" "334.6" "206.3" "96.2" "190.9" "87.0" "149.3" "235.2" "183.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TAG9" "Exocyst complex component 6 OS=Homo sapiens OX=9606 GN=EXOC6 PE=1 SV=3" "1" "1" "2" "1" "804" "93.7" "6.20" "382.79" "4.77" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf04091" "54536" "ENSG00000138190" "EXOC6" "E9PHI3; hsa:54536; Q5VXH8; Q8TAG9; Q9NZ24" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Interactions between LOXL4 and oxidative stress pathway; Ciliary landscape" "5" "0" "14.4" "12.7" "19.7" "60.2" "32.5" "17.3" "36.0" "34.8" "99.6" "584.6" "435.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43663" "Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2" "6" "3" "6" "3" "620" "71.6" "6.68" "1715.84" "4.76" "3" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03999" "9055" "ENSG00000198901" "PRC1" "A6NC44; B4DLR1; H9KV59; hsa:9055; O43663; Q9BSB6" "RHO GTPases activate CIT" "" "1" "0" "65.8" "60.0" "63.2" "172.2" "83.4" "66.1" "117.9" "53.6" "110.0" "436.1" "428.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "2" "1" "2" "1" "1026" "117.3" "5.55" "567.82" "4.76" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "39.3" "41.0" "46.7" "141.6" "64.8" "42.9" "64.8" "39.8" "41.6" "111.6" "116.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04844" "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3" "3" "1" "2" "1" "631" "69.2" "5.69" "501.85" "4.74" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "translation activity" "Pf05817" "6185" "ENSG00000118705" "RPN2" "hsa:6185; P04844; Q5JYR6; Q6IBA5; Q96E21; Q9BUQ3; Q9UBE1" "SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein" "Proteasome degradation; N-glycan biosynthesis" "5" "0" "7.2" "4.0" "13.5" "59.8" "16.0" "8.9" "15.2" "9.4" "8.4" "69.2" "68.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "3" "2" "3" "2" "602" "68.2" "6.43" "240.88" "4.74" "1" "2" "" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "8.1" "7.6" "14.5" "82.5" "33.5" "7.7" "15.4" "13.7" "11.4" "26.1" "22.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "3" "1" "2" "1" "529" "59.5" "8.92" "427.30" "4.72" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "" "3" "0" "5.1" "6.3" "8.7" "26.0" "12.6" "6.1" "12.6" "10.8" "10.6" "68.1" "83.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "6" "2" "3" "2" "430" "47.5" "9.01" "1023.46" "4.71" "2" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis" "10" "0" "229.8" "217.6" "365.7" "791.9" "475.6" "209.0" "261.4" "218.9" "275.8" "319.9" "262.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13084" "39S ribosomal protein L28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" "11" "2" "2" "2" "256" "30.1" "8.29" "253.75" "4.70" "1" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00830" "10573" "ENSG00000086504" "MRPL28" "B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "55.4" "66.0" "89.3" "370.2" "135.7" "59.7" "146.8" "88.1" "84.4" "301.2" "271.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "5" "2" "3" "2" "376" "42.9" "5.81" "807.30" "4.69" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "144.1" "161.7" "235.8" "810.7" "337.7" "197.9" "352.4" "193.9" "228.4" "898.7" "763.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "3" "1" "2" "1" "661" "75.0" "6.37" "511.84" "4.69" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "tRNA modification in the nucleus and cytosol" "" "1" "0" "5.3" "1.7" "5.7" "36.1" "13.4" "3.1" "10.0" "7.9" "10.8" "15.8" "16.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "4" "2" "4" "2" "513" "57.5" "7.18" "496.32" "4.68" "2" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "mRNA Splicing - Major Pathway" "" "1" "0" "68.3" "58.5" "78.0" "184.5" "111.0" "66.2" "121.6" "57.3" "90.1" "261.0" "263.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "12" "3" "4" "3" "346" "38.4" "5.30" "555.28" "4.66" "2" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "" "2" "0" "58.0" "67.3" "100.0" "821.8" "205.9" "22.0" "97.6" "96.6" "95.4" "270.7" "342.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HCE1" "Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2" "2" "2" "4" "2" "1003" "113.6" "8.82" "604.24" "4.65" "2" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13087, Pf13604" "4343" "ENSG00000155363" "MOV10" "hsa:4343; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9; Q9HCE1" "Estrogen-dependent gene expression; TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "VEGFA-VEGFR2 signaling" "18" "0" "145.8" "130.6" "208.3" "465.4" "238.0" "133.6" "304.7" "143.5" "182.3" "533.0" "453.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43301" "Heat shock 70 kDa protein 12A OS=Homo sapiens OX=9606 GN=HSPA12A PE=1 SV=2" "4" "2" "3" "2" "675" "74.9" "6.77" "278.77" "4.65" "1" "2" "" "nucleus;other cell component" "other molecular function" "" "259217" "ENSG00000165868" "HSPA12A" "hsa:259217; O43301" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "175.5" "183.1" "240.7" "479.2" "273.1" "187.0" "289.9" "161.3" "222.9" "512.6" "338.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "5" "1" "2" "1" "290" "32.3" "5.14" "504.93" "4.65" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "36.8" "26.2" "38.6" "125.7" "60.0" "42.4" "80.7" "54.3" "96.5" "228.2" "228.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6M9" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Homo sapiens OX=9606 GN=NDUFB9 PE=1 SV=3" "9" "1" "2" "1" "179" "21.8" "8.38" "501.86" "4.64" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf05347" "4715" "ENSG00000147684" "NDUFB9" "B2R8M6; hsa:4715; Q9UQE8; Q9Y6M9" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation" "6" "0" "37.7" "42.3" "50.1" "156.0" "69.0" "35.3" "58.2" "53.6" "53.3" "132.8" "116.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z406" "Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2" "2" "4" "7" "2" "1995" "227.7" "5.60" "2127.26" "4.63" "3" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "79784" "ENSG00000105357" "MYH14" "B0I1S2; C3TTN4; hsa:79784; Q5CZ75; Q6XYE4; Q76B62; Q7Z406; Q8WV23; Q96I22; Q9BT27; Q9BW35; Q9H882" "EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases activate PAKs" "" "6" "0" "191.0" "122.7" "252.3" "705.4" "341.7" "200.3" "382.5" "122.8" "263.6" "704.3" "363.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13889" "General transcription factor IIH subunit 3 OS=Homo sapiens OX=9606 GN=GTF2H3 PE=1 SV=2" "6" "1" "2" "1" "308" "34.4" "7.02" "458.73" "4.62" "1" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03850" "2967" "ENSG00000111358" "GTF2H3" "B2R819; B4DNZ6; hsa:2967; Q13889; Q7L0G0; Q96AT7" "NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 11p11.2 copy number variation syndrome" "34" "0" "15.3" "12.9" "17.0" "33.3" "20.4" "13.2" "35.5" "70.7" "192.2" "426.4" "269.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "2" "1" "2" "1" "714" "81.8" "5.67" "561.67" "4.61" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "hsa:823; P07384; Q2TTR0; Q6DHV4" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "7" "0" "16.6" "12.8" "24.1" "135.3" "40.9" "16.6" "57.1" "22.7" "29.1" "171.4" "116.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "4" "1" "2" "1" "485" "53.3" "7.34" "417.20" "4.61" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "" "17q12 copy number variation syndrome" "1" "0" "17.2" "16.4" "26.7" "74.9" "36.6" "16.1" "30.3" "25.7" "24.0" "67.5" "68.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "1" "1" "2" "1" "1087" "120.9" "5.06" "494.24" "4.60" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "20" "0" "16.7" "20.6" "17.7" "54.0" "18.0" "16.3" "34.6" "16.2" "15.8" "49.8" "36.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9C0D5" "Protein TANC1 OS=Homo sapiens OX=9606 GN=TANC1 PE=1 SV=3" "1" "2" "3" "2" "1861" "202.1" "8.32" "250.84" "4.59" "1" "2" "cell organization and biogenesis;other biological processes" "other cell component" "" "Pf00023, Pf12796" "85461" "ENSG00000115183" "TANC1" "C9JD88; hsa:85461; Q49AI8; Q9C0D5" "" "" "0" "0" "54.9" "35.8" "58.5" "124.7" "71.0" "47.8" "116.1" "37.7" "67.2" "262.0" "210.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=3" "3" "1" "2" "1" "517" "57.2" "6.80" "480.79" "4.59" "1" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "12.9" "21.2" "28.9" "210.5" "65.5" "15.5" "35.1" "43.9" "25.6" "75.5" "77.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "1" "1" "2" "1" "2442" "265.2" "8.53" "345.77" "4.58" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; hsa:1387; O00147; Q16376; Q4LE28; Q92793" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; SUMOylation of transcription cofactors; Formation of paraxial mesoderm; Pre-NOTCH Transcription and Translation; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; Activation of the TFAP2 (AP-2) family of transcription factors; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; NPAS4 regulates expression of target genes; Heme signaling; Formation of the beta-catenin:TCF transactivating complex; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NFE2L2 regulating anti-oxidant/detoxification enzymes; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "63" "0" "18.8" "12.6" "31.0" "72.3" "30.6" "20.7" "45.0" "27.0" "28.2" "120.7" "113.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "2" "1" "2" "1" "1309" "146.6" "6.13" "390.18" "4.57" "1" "1" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "" "Translation factors" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "16" "1" "1" "1" "147" "16.7" "7.80" "" "4.56" "" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; hsa:7323; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Proteasome degradation" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P0C7P4" "Putative cytochrome b-c1 complex subunit Rieske-like protein 1 OS=Homo sapiens OX=9606 GN=UQCRFS1P1 PE=5 SV=1" "5" "2" "2" "2" "283" "30.8" "8.87" "" "4.56" "" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "" "" "UQCRFS1P1" "P0C7P4" "" "" "0" "0" "222.0" "181.6" "304.9" "590.3" "379.5" "179.6" "365.6" "278.2" "326.3" "573.7" "497.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WUF5" "RelA-associated inhibitor OS=Homo sapiens OX=9606 GN=PPP1R13L PE=1 SV=4" "3" "2" "3" "2" "828" "89.0" "6.81" "242.45" "4.55" "1" "2" "RNA metabolism OR transcription;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796, Pf14604" "10848" "ENSG00000104881" "PPP1R13L" "hsa:10848; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q8WUF5; Q9Y290" "Regulation of TP53 Activity through Association with Co-factors" "IL-18 signaling pathway" "2" "0" "12.8" "11.5" "16.6" "30.6" "20.7" "16.2" "21.1" "14.7" "16.8" "32.6" "29.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q09666" "Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2" "1" "2" "4" "2" "5890" "628.7" "6.15" "238.80" "4.54" "1" "2" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "79026" "ENSG00000124942" "AHNAK" "A1A586; hsa:79026; Q09666" "" "" "0" "0" "7.7" "3.8" "9.6" "31.5" "5.0" "2.2" "7.2" "8.2" "6.6" "22.0" "33.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "4" "1" "2" "1" "325" "37.2" "8.05" "376.87" "4.54" "1" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Primary focal segmental glomerulosclerosis (FSGS)" "3" "0" "22.7" "30.6" "41.4" "130.5" "59.1" "29.3" "47.1" "39.8" "41.0" "159.1" "208.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A0A096LP55" "Cytochrome b-c1 complex subunit 6-like, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRHL PE=3 SV=1" "7" "1" "4" "1" "91" "10.7" "4.44" "501.66" "4.53" "1" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "" "Pf02320" "440567" "ENSG00000233954" "UQCRHL" "A0A096LP55; hsa:440567" "" "Nonalcoholic fatty liver disease" "1" "0" "308.8" "283.2" "455.7" "1068.5" "533.0" "266.1" "487.3" "279.9" "328.3" "689.4" "611.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "4" "1" "2" "1" "399" "44.2" "4.73" "496.34" "4.53" "1" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Polymerase switching on the C-strand of the telomere; Removal of the Flap Intermediate from the C-strand; Telomere Extension By Telomerase; Telomere C-strand synthesis initiation" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "16" "0" "32.6" "38.8" "46.6" "154.0" "59.4" "31.1" "64.7" "39.9" "53.9" "140.9" "84.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14893" "Gem-associated protein 2 OS=Homo sapiens OX=9606 GN=GEMIN2 PE=1 SV=1" "8" "1" "1" "1" "280" "31.6" "5.58" "" "4.53" "" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04938" "8487" "ENSG00000092208" "GEMIN2" "B2R9W8; hsa:8487; O14893; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "6.9" "9.5" "15.3" "38.4" "22.6" "13.4" "27.0" "15.4" "11.6" "27.2" "16.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "6" "2" "4" "1" "282" "31.3" "9.83" "622.48" "4.53" "2" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "111.0" "82.0" "117.2" "225.3" "135.8" "97.6" "170.3" "73.7" "96.6" "192.0" "110.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "3" "2" "3" "2" "864" "94.2" "5.11" "297.09" "4.51" "1" "2" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "EGF/EGFR signaling pathway" "4" "0" "8.2" "6.6" "12.4" "38.7" "18.7" "10.6" "16.3" "9.9" "16.5" "48.8" "94.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H939" "Proline-serine-threonine phosphatase-interacting protein 2 OS=Homo sapiens OX=9606 GN=PSTPIP2 PE=1 SV=4" "4" "1" "2" "1" "334" "38.8" "8.48" "275.57" "4.51" "1" "1" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00611" "9050" "ENSG00000152229" "PSTPIP2" "hsa:9050; Q9H939" "" "" "0" "0" "48.0" "22.4" "36.6" "57.8" "48.9" "49.8" "72.7" "24.3" "56.4" "129.8" "67.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "4" "1" "2" "1" "346" "36.2" "8.79" "387.98" "4.50" "1" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Citric acid cycle (TCA cycle)" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "3" "0" "66.4" "68.0" "111.1" "462.4" "158.2" "90.8" "113.3" "94.1" "101.4" "206.3" "206.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "19" "1" "2" "1" "68" "7.4" "7.24" "517.37" "4.50" "1" "1" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "Copper homeostasis" "3" "0" "76.3" "68.0" "103.9" "837.8" "175.2" "27.4" "164.7" "86.0" "91.8" "304.2" "156.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "4" "1" "2" "1" "541" "56.6" "5.48" "475.37" "4.49" "1" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "RAC1 GTPase cycle; RHOH GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Amino acid transport across the plasma membrane" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "11" "0" "43.4" "36.9" "58.0" "180.5" "80.8" "44.2" "74.1" "36.1" "49.3" "138.4" "113.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRP0" "Oligosaccharyltransferase complex subunit OSTC OS=Homo sapiens OX=9606 GN=OSTC PE=1 SV=1" "8" "1" "2" "1" "149" "16.8" "9.13" "324.18" "4.49" "1" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "" "Pf04756" "58505" "ENSG00000198856" "OSTC" "A8MYS2; B2R5H1; D6RH22; hsa:58505; Q9NRP0; Q9P075; Q9P1R4" "" "" "0" "0" "36.1" "32.1" "56.3" "189.4" "97.5" "45.0" "72.2" "48.5" "51.2" "140.2" "179.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "12" "1" "2" "1" "162" "18.8" "8.66" "529.79" "4.48" "1" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "" "2" "0" "3.4" "7.8" "7.7" "48.6" "14.0" "6.4" "16.3" "14.1" "19.7" "40.3" "31.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60604" "Ubiquitin-conjugating enzyme E2 G2 OS=Homo sapiens OX=9606 GN=UBE2G2 PE=1 SV=1" "15" "1" "1" "1" "165" "18.6" "4.70" "" "4.46" "" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf00179" "7327" "ENSG00000184787" "UBE2G2" "A6NMQ7; A8K3L4; D3DSL7; hsa:7327; P56554; P60604" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "4" "0" "5.1" "3.5" "9.1" "24.2" "11.4" "3.8" "10.2" "5.0" "6.7" "35.9" "14.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9C037" "E3 ubiquitin-protein ligase TRIM4 OS=Homo sapiens OX=9606 GN=TRIM4 PE=1 SV=2" "2" "1" "6" "1" "500" "57.4" "8.10" "245.54" "4.46" "1" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00622, Pf00643, Pf15227" "89122" "ENSG00000146833" "TRIM4" "A4D298; hsa:89122; Q75MK1; Q96F06; Q9C036; Q9C037" "Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling; TRAF6 mediated IRF7 activation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway" "" "9" "0" "113.2" "87.7" "89.7" "342.6" "115.4" "60.6" "95.1" "95.8" "99.0" "320.8" "583.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13136" "Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1" "5" "4" "5" "4" "1202" "135.7" "6.29" "1525.37" "4.45" "3" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "" "Pf00536, Pf07647" "8500" "ENSG00000131626" "PPFIA1" "A6NLE3; hsa:8500; Q13135; Q13136; Q14567; Q8N4I2" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "" "6" "0" "484.8" "429.0" "532.1" "640.5" "510.4" "477.4" "665.9" "308.9" "475.0" "769.5" "467.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "2" "1" "2" "1" "741" "82.5" "5.06" "456.38" "4.45" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "Condensation of Prometaphase Chromosomes" "2q11.2 copy number variation syndrome" "2" "0" "74.8" "71.8" "75.7" "186.4" "87.0" "49.6" "96.3" "59.5" "76.1" "234.3" "186.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IUD2" "ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1" "1" "1" "2" "1" "1116" "128.0" "5.97" "493.12" "4.43" "1" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09457, Pf10174" "23085" "ENSG00000082805" "ERC1" "A2RU77; A7E295; D3DUP7; D3DUP8; hsa:23085; Q6NVK2; Q8IUD2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; Q9UPS1" "" "" "0" "0" "25.7" "23.8" "36.1" "128.3" "50.1" "29.3" "63.1" "37.6" "45.0" "163.3" "183.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "11" "1" "2" "1" "156" "18.0" "8.21" "267.20" "4.42" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); mRNA Splicing - Major Pathway; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "14.1" "9.8" "14.2" "28.5" "17.7" "13.3" "21.5" "12.2" "9.0" "26.8" "13.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQ75" "Protein CMSS1 OS=Homo sapiens OX=9606 GN=CMSS1 PE=1 SV=2" "6" "1" "2" "1" "279" "31.9" "9.19" "478.10" "4.41" "1" "1" "" "" "" "Pf14617" "84319" "ENSG00000184220" "CMSS1" "A8K5S7; B4DUM1; E9PHS3; hsa:84319; Q9BQ75" "" "" "0" "0" "15.2" "13.3" "11.6" "32.3" "22.7" "12.1" "24.8" "16.4" "9.3" "43.6" "33.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NCM8" "Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC2H1 PE=1 SV=4" "1" "2" "3" "2" "4307" "492.3" "6.54" "368.47" "4.41" "1" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf18198, Pf18199" "79659" "ENSG00000187240" "DYNC2H1" "hsa:79659; O00432; Q16693; Q3C1U8; Q4AC93; Q6ZMX7; Q6ZUM6; Q7Z363; Q8N977; Q8NCM8; Q92815; Q9HAE4" "Hedgehog 'off' state; Intraflagellar transport" "Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome; Bardet-Biedl syndrome" "7" "0" "2.7" "6.6" "7.6" "23.4" "14.6" "7.9" "7.6" "9.3" "9.3" "27.4" "22.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3D2" "Methionine-R-sulfoxide reductase B2, mitochondrial OS=Homo sapiens OX=9606 GN=MSRB2 PE=1 SV=2" "5" "1" "2" "1" "182" "19.5" "8.63" "420.32" "4.40" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01641" "22921" "ENSG00000148450" "MSRB2" "hsa:22921; Q17R44; Q4G1C7; Q9Y3D2; Q9Y5W6" "Protein repair" "Sulindac metabolic pathway; Methionine de novo and salvage pathway" "3" "0" "41.3" "37.1" "53.5" "116.3" "59.2" "46.1" "103.1" "41.6" "56.6" "164.9" "109.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13356" "RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1" "4" "1" "1" "1" "520" "58.8" "8.78" "" "4.40" "" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "23759" "ENSG00000100023" "PPIL2" "hsa:23759; Q13356; Q13357; Q8TAH2; Q9BWR8" "mRNA Splicing - Major Pathway; Basigin interactions" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZN3" "EH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=EHD3 PE=1 SV=2" "5" "3" "3" "2" "535" "60.8" "6.57" "371.47" "4.39" "1" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30845" "ENSG00000013016" "EHD3" "B4DFR5; D6W574; hsa:30845; Q8N514; Q9NZB3; Q9NZN3" "Factors involved in megakaryocyte development and platelet production" "Ciliary landscape" "2" "0" "203.0" "199.1" "298.1" "856.4" "351.9" "203.1" "404.4" "212.4" "250.4" "801.8" "735.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N5K1" "CDGSH iron-sulfur domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CISD2 PE=1 SV=1" "10" "1" "2" "1" "135" "15.3" "9.61" "413.18" "4.38" "1" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf09360, Pf10660" "493856" "ENSG00000145354" "CISD2" "hsa:493856; Q7Z3D5; Q8N5K1" "" "" "0" "0" "26.0" "36.4" "55.0" "186.6" "75.3" "38.8" "56.8" "39.1" "35.5" "100.8" "97.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "3" "1" "2" "1" "418" "45.9" "6.46" "630.04" "4.38" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "55.0" "44.8" "62.7" "137.8" "83.7" "44.0" "91.2" "50.5" "62.6" "90.6" "57.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "2" "1" "2" "1" "861" "97.1" "5.64" "560.95" "4.36" "1" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "4.7" "6.8" "5.4" "44.4" "14.3" "2.5" "15.4" "8.0" "7.3" "38.7" "33.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "5" "1" "2" "1" "316" "34.8" "8.35" "515.27" "4.36" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "0.0" "2.7" "5.3" "11.4" "2.3" "2.1" "2.3" "5.7" "10.6" "45.7" "114.0" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "3" "1" "1" "1" "747" "86.1" "6.62" "" "4.35" "" "1" "transport" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "Synthesis of PIPs at the early endosome membrane" "" "1" "0" "7.2" "6.6" "13.4" "23.4" "16.1" "10.1" "15.1" "10.7" "11.2" "52.8" "48.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NP92" "39S ribosomal protein S30, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "3" "1" "2" "1" "439" "50.3" "7.97" "414.01" "4.35" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "185.1" "181.6" "220.4" "582.7" "283.3" "161.0" "304.7" "154.5" "176.3" "426.4" "308.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "7" "1" "2" "1" "261" "29.3" "6.70" "506.95" "4.33" "1" "1" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Pyrimidine salvage" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "0" "20.1" "18.3" "27.4" "112.0" "43.4" "17.0" "37.8" "24.5" "26.4" "62.1" "72.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6PJI9" "GATOR complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2" "1" "1" "2" "1" "974" "109.7" "7.91" "559.63" "4.33" "1" "1" "stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf17120" "79726" "ENSG00000103091" "WDR59" "B3KRC3; hsa:79726; Q6PJI9; Q71RE7; Q96PW5; Q9BSW6; Q9HA43" "Amino acids regulate mTORC1" "" "1" "0" "10.1" "9.5" "20.7" "29.9" "18.0" "12.9" "18.1" "13.4" "18.2" "57.9" "48.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "4" "1" "1" "1" "559" "61.5" "7.50" "" "4.32" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "6.8" "7.9" "9.7" "39.2" "15.7" "4.9" "22.9" "7.7" "11.7" "65.3" "120.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "1" "1" "2" "1" "923" "102.8" "5.22" "476.46" "4.31" "1" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "115.9" "88.7" "125.1" "245.9" "148.5" "110.3" "180.2" "70.0" "105.0" "147.6" "65.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "3" "1" "2" "1" "452" "51.3" "8.32" "481.23" "4.31" "1" "1" "cell organization and biogenesis;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "Mitochondrial protein import" "" "1" "0" "27.1" "23.4" "31.4" "86.9" "41.5" "27.0" "43.6" "39.5" "41.6" "149.2" "142.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPN4" "Centrosomal protein of 131 kDa OS=Homo sapiens OX=9606 GN=CEP131 PE=1 SV=3" "1" "1" "2" "1" "1083" "122.1" "8.69" "256.60" "4.30" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22994" "ENSG00000141577" "CEP131" "A6NHI8; B2RN11; hsa:22994; Q96F50; Q9UPN4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "80.3" "45.0" "66.2" "110.7" "73.7" "66.9" "80.3" "44.3" "64.4" "89.5" "67.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q3V6T2" "Girdin OS=Homo sapiens OX=9606 GN=CCDC88A PE=1 SV=2" "1" "2" "5" "1" "1871" "215.9" "6.21" "772.70" "4.29" "2" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "55704" "ENSG00000115355" "CCDC88A" "A1IGE7; B7ZM78; C9JG83; hsa:55704; Q3V6T2; Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5" "RND3 GTPase cycle; RND1 GTPase cycle" "Mesodermal commitment pathway" "3" "0" "58.2" "66.4" "101.6" "531.7" "194.6" "29.3" "74.5" "84.3" "59.6" "150.0" "183.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75947" "ATP synthase subunit d, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PD PE=1 SV=3" "11" "1" "2" "1" "161" "18.5" "5.30" "439.46" "4.28" "1" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05873" "10476" "ENSG00000167863" "ATP5PD" "B2R5L6; hsa:10476; O75947; Q9H3J4" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "22.8" "30.1" "37.0" "206.1" "66.4" "39.7" "58.1" "46.6" "50.3" "231.9" "308.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "8" "1" "2" "1" "204" "23.4" "5.49" "540.32" "4.28" "1" "1" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "8.0" "6.6" "9.5" "45.3" "16.8" "9.1" "10.8" "9.2" "11.6" "28.3" "30.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "2" "2" "3" "2" "1328" "149.2" "6.74" "245.91" "4.27" "1" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "Gastric cancer network 2; DNA repair pathways, full network" "4" "0" "9.0" "4.6" "1.4" "17.7" "13.7" "6.1" "8.1" "8.2" "9.2" "24.8" "16.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96IY1" "Kinetochore-associated protein NSL1 homolog OS=Homo sapiens OX=9606 GN=NSL1 PE=1 SV=3" "6" "1" "2" "1" "281" "32.1" "6.79" "432.94" "4.26" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08641" "25936" "ENSG00000117697" "NSL1" "E7ETD5; hsa:25936; Q5SY75; Q96IY1; Q9H2M5; Q9NRN8; Q9Y415" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "2.9" "1.8" "3.3" "19.5" "8.5" "4.3" "11.3" "8.8" "14.7" "114.5" "92.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62877" "E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1" "13" "1" "2" "1" "108" "12.3" "6.96" "500.58" "4.25" "1" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9978" "ENSG00000100387" "RBX1" "B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254" "Potential therapeutics for SARS; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome" "46" "0" "112.4" "102.8" "134.5" "565.1" "186.2" "120.7" "205.4" "113.7" "138.4" "676.1" "908.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "5" "1" "2" "1" "237" "26.2" "4.11" "429.35" "4.24" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "snRNP Assembly" "" "1" "0" "37.2" "32.5" "42.5" "184.7" "81.5" "43.0" "64.4" "52.6" "43.9" "119.5" "102.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "2" "1" "2" "1" "594" "67.2" "5.96" "418.38" "4.24" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "9.7" "12.1" "19.2" "51.1" "26.7" "16.0" "25.9" "17.9" "20.7" "177.0" "309.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51398" "28S ribosomal protein S29, mitochondrial OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "4" "1" "2" "1" "398" "45.5" "8.88" "375.58" "4.24" "1" "1" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "CKAP4 signaling pathway map" "4" "0" "39.5" "40.5" "39.7" "106.7" "59.5" "43.7" "66.4" "49.3" "96.0" "225.2" "156.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BV57" "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "12" "2" "3" "2" "179" "21.5" "5.68" "802.66" "4.23" "2" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "216.8" "194.8" "285.7" "1020.4" "409.5" "199.0" "398.4" "188.5" "249.2" "529.6" "346.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TF74" "WAS/WASL-interacting protein family member 2 OS=Homo sapiens OX=9606 GN=WIPF2 PE=1 SV=1" "5" "1" "1" "1" "440" "46.3" "10.93" "" "4.22" "" "1" "" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf02205" "147179" "ENSG00000171475" "WIPF2" "A8K0L3; hsa:147179; Q658J8; Q71RE1; Q8TE44; Q8TF74" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle" "" "6" "0" "34.0" "34.2" "42.3" "67.8" "43.0" "36.5" "56.1" "27.3" "28.1" "57.8" "45.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IU81" "Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1" "4" "1" "1" "1" "584" "61.6" "8.18" "" "4.21" "" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00097, Pf11261" "26145" "ENSG00000170604" "IRF2BP1" "hsa:26145; Q53EL7; Q6DC95; Q8IU81; Q9BRZ9; Q9Y4P4" "" "" "0" "0" "63.3" "42.0" "75.4" "85.1" "81.5" "71.0" "87.2" "75.9" "145.4" "495.4" "569.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IVH8" "Mitogen-activated protein kinase kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP4K3 PE=1 SV=1" "1" "1" "2" "1" "894" "101.3" "7.56" "338.77" "4.21" "1" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "8491" "ENSG00000011566" "MAP4K3" "hsa:8491; Q6IQ39; Q8IVH7; Q8IVH8; Q9UDM5; Q9Y6R5" "" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "6" "0" "12.1" "10.7" "10.6" "29.0" "19.4" "10.8" "20.8" "16.4" "20.6" "115.7" "96.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15091" "Mitochondrial ribonuclease P catalytic subunit OS=Homo sapiens OX=9606 GN=PRORP PE=1 SV=2" "3" "1" "2" "1" "583" "67.3" "8.78" "442.24" "4.20" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf16953" "9692" "ENSG00000100890" "PRORP" "B4DXD9; B4E0S8; B4E211; C4AM93; D3DS99; D3DSA1; hsa:9692; O15091; Q86SZ4; Q86YB5; Q8N5L5" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "" "3" "0" "31.1" "30.5" "29.2" "65.6" "34.0" "28.5" "49.9" "28.9" "36.5" "91.3" "67.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08209" "Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "2" "1" "2" "1" "521" "58.7" "5.86" "375.07" "4.18" "1" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "DARPP-32 events; FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway" "25" "0" "10.8" "8.5" "12.7" "53.8" "24.7" "10.0" "18.3" "15.0" "11.5" "39.7" "37.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "5" "1" "2" "1" "243" "27.9" "4.20" "483.03" "4.17" "1" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "" "" "0" "0" "58.4" "52.0" "77.8" "333.5" "126.0" "48.6" "91.7" "53.4" "74.8" "133.9" "83.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "4" "1" "2" "1" "400" "43.4" "5.10" "474.58" "4.16" "1" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "7" "1" "2" "1" "227" "26.5" "8.41" "466.59" "4.13" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "" "2" "0" "55.8" "50.7" "68.5" "208.2" "85.0" "66.1" "106.7" "67.5" "70.3" "233.0" "191.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H0W8" "Protein SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1" "3" "1" "2" "1" "520" "57.6" "7.01" "627.78" "4.12" "1" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf10220" "56006" "ENSG00000105771" "SMG9" "hsa:56006; O60429; Q9H0W8; Q9H9A9" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "10.8" "11.8" "9.0" "16.4" "11.2" "12.5" "16.9" "8.7" "8.0" "20.8" "11.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IYB5" "Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2" "2" "1" "2" "1" "467" "50.4" "8.75" "369.50" "4.12" "1" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "60682" "ENSG00000112305" "SMAP1" "hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4" "" "" "0" "0" "55.6" "45.7" "61.8" "157.0" "89.0" "57.4" "128.0" "57.8" "74.5" "187.3" "112.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54098" "DNA polymerase subunit gamma-1 OS=Homo sapiens OX=9606 GN=POLG PE=1 SV=1" "2" "1" "2" "1" "1239" "139.5" "6.90" "477.38" "4.11" "1" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00476, Pf18136" "5428" "ENSG00000140521" "POLG" "hsa:5428; P54098; Q8NFM2; Q92515" "" "Male infertility; Primary ovarian insufficiency" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H2D6" "TRIO and F-actin-binding protein OS=Homo sapiens OX=9606 GN=TRIOBP PE=1 SV=3" "1" "1" "2" "1" "2365" "261.2" "8.48" "371.14" "4.11" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169" "11078" "ENSG00000100106" "TRIOBP" "B1AHD4; B1AHD7; F2Z2W0; F8W6V6; hsa:11078; O94797; Q2PZW8; Q2Q3Z9; Q2Q400; Q5R3M6; Q96DW1; Q9BT77; Q9BTL7; Q9BY98; Q9H2D6; Q9Y3L4" "" "" "0" "0" "19.2" "23.2" "35.3" "103.6" "42.6" "25.9" "40.2" "42.3" "38.1" "207.4" "196.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P1K2" "Polyamine-modulated factor 1 OS=Homo sapiens OX=9606 GN=PMF1 PE=1 SV=2" "6" "1" "2" "1" "205" "23.3" "5.49" "332.15" "4.10" "1" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03980" "100527963; 11243" "ENSG00000160783" "PMF1" "A8K0C5; hsa:100527963; hsa:11243; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6P1K2; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "3.3" "3.9" "10.1" "37.3" "12.0" "9.3" "33.5" "39.3" "79.2" "428.3" "327.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6Y288" "Beta-1,3-glucosyltransferase OS=Homo sapiens OX=9606 GN=B3GLCT PE=1 SV=2" "3" "1" "2" "1" "498" "56.5" "7.50" "337.53" "4.10" "1" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02434" "145173" "ENSG00000187676" "B3GLCT" "A8K5F8; hsa:145173; Q5W0H2; Q6NUI3; Q6Y288" "Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins" "" "2" "0" "20.3" "20.2" "40.8" "112.9" "49.4" "31.6" "37.5" "21.0" "32.4" "91.7" "131.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "6" "1" "2" "1" "361" "39.3" "7.18" "498.28" "4.09" "1" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "2" "1" "2" "1" "641" "70.0" "8.38" "454.98" "4.08" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "mRNA Splicing - Major Pathway" "" "1" "0" "19.8" "16.1" "18.8" "42.2" "27.3" "19.9" "44.8" "29.2" "65.0" "160.0" "70.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15313" "V-type proton ATPase subunit B, kidney isoform OS=Homo sapiens OX=9606 GN=ATP6V1B1 PE=1 SV=3" "3" "1" "2" "1" "513" "56.8" "5.66" "425.58" "4.08" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "525" "ENSG00000116039" "ATP6V1B1" "hsa:525; P15313; Q53FY0; Q6P4H6" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "19.4" "16.0" "17.1" "47.5" "27.3" "15.0" "19.9" "18.5" "18.8" "64.3" "52.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "4" "2" "3" "1" "463" "50.5" "9.52" "634.05" "4.08" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "1" "106.3" "93.5" "119.2" "397.8" "177.6" "101.2" "179.0" "114.9" "128.2" "451.3" "421.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "1" "1" "2" "1" "1358" "153.0" "7.17" "459.28" "4.07" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; DNA damage response (only ATM dependent)" "24" "0" "72.5" "62.2" "80.1" "169.5" "101.0" "71.0" "120.3" "79.9" "86.0" "269.0" "327.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H2W6" "39S ribosomal protein L46, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "5" "1" "2" "1" "279" "31.7" "7.05" "268.96" "4.06" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "42.8" "41.4" "71.0" "205.1" "79.6" "48.5" "93.1" "56.0" "49.3" "231.0" "212.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "4" "2" "3" "2" "564" "66.7" "6.34" "638.30" "4.06" "2" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "160.1" "162.6" "207.1" "518.6" "275.9" "207.3" "376.6" "191.1" "241.6" "806.0" "596.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O77932" "Decapping and exoribonuclease protein OS=Homo sapiens OX=9606 GN=DXO PE=2 SV=2" "4" "1" "2" "1" "396" "44.9" "7.69" "450.31" "4.05" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf08652" "1797" "ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765" "DXO" "A2CER3; B0UZ80; hsa:1797; O15004; O77932; O78127; O78128; Q5ST60; Q6IPZ2; Q9NPK4" "" "" "0" "0" "20.3" "15.6" "26.8" "58.8" "34.2" "25.1" "39.6" "22.8" "23.9" "68.0" "55.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "1" "1" "2" "1" "1041" "119.2" "6.80" "349.24" "4.04" "1" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "12.5" "14.6" "20.2" "59.8" "24.0" "14.8" "28.3" "21.5" "25.0" "67.6" "90.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H425" "Uncharacterized protein C1orf198 OS=Homo sapiens OX=9606 GN=C1orf198 PE=1 SV=1" "4" "1" "2" "1" "327" "36.3" "5.72" "478.75" "4.04" "1" "1" "" "cytosol" "" "Pf15797" "84886" "ENSG00000119280" "C1orf198" "A8K8R8; B3KTW1; G5EA08; hsa:84886; Q9H425" "" "" "0" "0" "11.0" "5.5" "10.2" "25.1" "15.9" "5.7" "15.8" "8.5" "9.9" "16.9" "8.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14126" "Desmoglein-2 OS=Homo sapiens OX=9606 GN=DSG2 PE=1 SV=2" "1" "1" "2" "1" "1118" "122.2" "5.24" "395.39" "4.03" "1" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028" "1829" "ENSG00000046604" "DSG2" "hsa:1829; Q14126; Q4KKU6" "Formation of the cornified envelope; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "Arrhythmogenic right ventricular cardiomyopathy; GDNF signaling" "8" "0" "17.3" "19.1" "18.2" "93.5" "33.0" "19.0" "23.7" "14.9" "23.5" "69.4" "62.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "1" "1" "2" "1" "778" "88.0" "6.80" "362.32" "4.02" "1" "1" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "70.8" "74.3" "81.2" "205.1" "104.4" "62.9" "122.4" "90.5" "135.8" "614.2" "718.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43709" "Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "10" "1" "1" "1" "281" "31.9" "8.73" "" "4.01" "" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "7q11.23 copy number variation syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "n/a" "High" "High" "High" "High" "n/a" "n/a" "High" "1" "" "False" "IsMasterProtein" "Q13643" "Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4" "4" "1" "2" "1" "280" "31.2" "6.20" "445.08" "4.01" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "2275" "ENSG00000183386" "FHL3" "D3DPT6; hsa:2275; Q13643; Q6I9T0; Q9BVA2" "" "" "0" "0" "114.7" "94.2" "166.7" "297.4" "152.5" "118.3" "270.9" "114.1" "131.6" "492.4" "207.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "1" "1" "2" "1" "855" "99.9" "6.23" "459.72" "4.00" "1" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "Rett syndrome causing genes; Nucleotide excision repair in xeroderma pigmentosum" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94813" "Slit homolog 2 protein OS=Homo sapiens OX=9606 GN=SLIT2 PE=1 SV=1" "1" "1" "2" "1" "1529" "169.8" "7.06" "370.91" "4.00" "1" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00008, Pf01462, Pf01463, Pf02210, Pf12661, Pf13855" "9353" "ENSG00000145147" "SLIT2" "A0A0A6YYB8; B7ZLR5; hsa:9353; O94813; O95710; Q17RU3; Q9Y5Q7" "Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity" "Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; Genes controlling nephrogenesis; GDNF/RET signaling axis; Development of ureteric collection system" "13" "0" "6.5" "7.3" "5.9" "21.5" "11.2" "8.5" "13.7" "5.1" "13.2" "65.9" "36.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P43250" "G protein-coupled receptor kinase 6 OS=Homo sapiens OX=9606 GN=GRK6 PE=1 SV=2" "2" "1" "2" "1" "576" "65.9" "8.00" "442.76" "4.00" "1" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00615" "2870" "ENSG00000198055" "GRK6" "hsa:2870; O60541; P43250; Q13652" "G alpha (s) signalling events" "Follicle stimulating hormone (FSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Calcium regulation in cardiac cells" "6" "0" "35.8" "24.4" "31.7" "77.8" "41.3" "39.2" "58.9" "64.0" "152.3" "513.5" "338.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "7" "1" "1" "1" "308" "33.4" "5.69" "" "3.99" "" "1" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "Cytosolic sulfonation of small molecules" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P05091" "Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2" "4" "2" "3" "2" "517" "56.3" "7.05" "669.21" "3.99" "2" "1" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00171" "217" "ENSG00000111275" "ALDH2" "B4DW54; E7EUE5; hsa:217; P05091; Q03639; Q6IB13; Q6IV71" "Smooth Muscle Contraction; Ethanol oxidation; Metabolism of serotonin" "Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity" "7" "0" "12.9" "11.8" "19.8" "146.0" "42.3" "2.5" "19.0" "20.2" "8.8" "38.9" "30.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "11" "2" "3" "2" "292" "33.5" "4.84" "991.62" "3.99" "2" "1" "other biological processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "21.4" "21.3" "29.7" "125.0" "45.3" "13.0" "27.8" "22.6" "28.0" "41.4" "41.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13051" "Uracil-DNA glycosylase OS=Homo sapiens OX=9606 GN=UNG PE=1 SV=2" "6" "2" "3" "2" "313" "34.6" "9.32" "565.55" "3.98" "2" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;nucleus" "translation activity;nucleic acid binding activity;other molecular function" "Pf03167" "7374" "ENSG00000076248" "UNG" "A8K5M6; B2R8Y1; hsa:7374; O00637; O00719; P13051; Q93028" "" "Base excision repair; DNA repair pathways, full network" "2" "0" "343.1" "220.7" "284.0" "464.4" "342.6" "281.2" "444.1" "187.3" "293.1" "580.8" "354.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "1" "1" "2" "1" "1019" "117.9" "6.61" "319.50" "3.98" "1" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "5" "0" "21.8" "11.6" "19.4" "103.1" "39.9" "12.5" "25.2" "17.4" "20.9" "52.9" "46.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "1" "1" "2" "1" "841" "95.9" "5.11" "377.13" "3.98" "1" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "13.5" "11.6" "25.4" "132.0" "35.8" "11.5" "34.7" "22.4" "24.9" "166.6" "211.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "2" "1" "2" "1" "940" "99.0" "9.17" "410.59" "3.97" "1" "1" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "48.0" "38.7" "48.4" "97.9" "63.2" "39.6" "66.5" "35.9" "52.6" "165.2" "157.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HC98" "Serine/threonine-protein kinase Nek6 OS=Homo sapiens OX=9606 GN=NEK6 PE=1 SV=2" "5" "1" "2" "1" "313" "35.7" "8.03" "400.36" "3.96" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "10783" "ENSG00000119408" "NEK6" "B7Z2D9; hsa:10783; Q5TBG3; Q5TBG9; Q6FG86; Q6IAR3; Q96E83; Q9HC98; Q9ULX2" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "" "3" "0" "9.6" "9.5" "9.0" "36.0" "18.9" "12.7" "17.6" "11.8" "24.5" "110.6" "131.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "3" "1" "2" "1" "522" "59.0" "5.15" "659.49" "3.95" "1" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "93.9" "83.1" "136.8" "398.4" "203.6" "86.4" "198.8" "79.2" "131.9" "215.8" "164.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "10" "1" "2" "1" "125" "14.6" "9.38" "325.79" "3.95" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "48.4" "60.1" "78.9" "342.3" "120.5" "59.3" "124.1" "69.4" "90.2" "391.1" "233.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WWV3" "Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RTN4IP1 PE=1 SV=2" "3" "1" "2" "1" "396" "43.6" "9.11" "454.22" "3.94" "1" "1" "developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf08240, Pf13602" "84816" "ENSG00000130347" "RTN4IP1" "hsa:84816; Q8N9B3; Q8WWV3; Q8WZ66; Q9BRA4" "" "" "0" "0" "18.8" "16.9" "28.6" "98.6" "35.3" "13.5" "28.4" "17.0" "24.9" "66.4" "52.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96F24" "Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1" "8" "1" "1" "1" "287" "32.4" "5.87" "" "3.94" "" "1" "other metabolic processes;stress response;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08961, Pf17169" "29982" "ENSG00000148572" "NRBF2" "A6PW36; B4DWS0; hsa:29982; Q86UR2; Q96F24; Q96NP6; Q9H0S9; Q9H2I2" "" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "2" "0" "8.4" "13.3" "17.9" "51.0" "25.8" "18.9" "26.1" "15.2" "19.9" "87.6" "118.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9GZR7" "ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1" "1" "1" "2" "1" "859" "96.3" "9.06" "459.15" "3.93" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "57062" "ENSG00000089737; ENSG00000273761" "DDX24" "E7EMJ4; hsa:57062; Q4V9L5; Q9GZR7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "5" "1" "2" "1" "341" "37.5" "7.43" "498.42" "3.93" "1" "1" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "2" "1" "2" "1" "776" "89.6" "8.00" "321.31" "3.93" "1" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Nuclear events stimulated by ALK signaling in cancer; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Pleural mesothelioma; Notch signaling pathway" "40" "0" "13.2" "13.6" "22.4" "40.5" "26.3" "22.7" "28.0" "20.0" "15.6" "69.9" "69.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "12" "1" "2" "1" "130" "14.4" "9.11" "383.32" "3.93" "1" "1" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "0" "10.1" "7.4" "15.1" "37.1" "12.7" "13.1" "20.7" "14.3" "23.2" "42.9" "47.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "4" "1" "2" "1" "418" "45.4" "7.99" "408.01" "3.93" "1" "1" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "5.2" "8.2" "12.6" "28.5" "18.4" "10.6" "20.5" "8.8" "9.8" "36.1" "24.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5UCC4" "ER membrane protein complex subunit 10 OS=Homo sapiens OX=9606 GN=EMC10 PE=1 SV=1" "5" "1" "2" "1" "262" "27.3" "6.13" "516.61" "3.92" "1" "1" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "" "" "284361" "ENSG00000161671" "EMC10" "hsa:284361; Q5UCC4; Q5UCC6; Q69YT5; Q6UWP3; Q86YL4; Q8N541" "" "22q11.2 copy number variation syndrome" "1" "0" "12.2" "8.9" "14.4" "37.1" "18.3" "11.4" "21.4" "10.3" "13.2" "38.9" "40.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96A35" "39S ribosomal protein L24, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "6" "1" "2" "1" "216" "24.9" "9.29" "431.04" "3.92" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "25.9" "23.3" "36.9" "107.7" "53.5" "27.7" "52.7" "34.6" "38.0" "108.6" "69.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNY4" "Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2" "1" "1" "2" "1" "1162" "129.5" "8.37" "439.07" "3.92" "1" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf06839" "8458" "ENSG00000116830" "TTF2" "A8K4Q2; hsa:8458; O75921; Q5T2K7; Q5VVU8; Q8N6I8; Q9UNY4" "" "Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "2" "0" "9.9" "13.4" "15.3" "35.7" "22.2" "18.5" "22.7" "14.9" "17.4" "53.5" "40.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82675" "28S ribosomal protein S5, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" "3" "1" "2" "1" "430" "48.0" "9.92" "420.80" "3.91" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00333, Pf03719" "64969" "ENSG00000144029" "MRPS5" "hsa:64969; P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "52.9" "45.1" "46.8" "130.0" "71.3" "49.3" "73.2" "46.7" "43.0" "77.8" "53.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5JXB2" "Putative ubiquitin-conjugating enzyme E2 N-like OS=Homo sapiens OX=9606 GN=UBE2NL PE=1 SV=1" "12" "1" "2" "1" "153" "17.4" "5.92" "563.78" "3.90" "1" "1" "protein metabolism;other metabolic processes" "nucleus" "other molecular function" "Pf00179" "389898" "" "UBE2NL" "E9KL27; hsa:389898; Q5JXB2" "" "" "0" "0" "30.7" "28.6" "56.3" "323.9" "76.1" "28.3" "47.0" "35.4" "39.8" "85.7" "116.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q641Q2" "WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3" "2" "2" "3" "2" "1341" "147.1" "4.81" "818.29" "3.89" "2" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "387680" "ENSG00000099290" "WASHC2A" "A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0" "" "10q11.21q11.23 copy number variation syndrome" "1" "0" "170.5" "143.1" "201.9" "579.1" "251.6" "176.4" "307.1" "178.5" "238.8" "719.2" "512.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86WR7" "Proline and serine-rich protein 2 OS=Homo sapiens OX=9606 GN=PROSER2 PE=1 SV=2" "3" "1" "2" "1" "435" "45.8" "7.20" "392.07" "3.87" "1" "1" "" "" "" "Pf15385" "254427" "ENSG00000148426" "PROSER2" "D3DRR8; hsa:254427; Q5W0J9; Q5W0K0; Q5W0K1; Q5W0K2; Q6PJC8; Q86WR7; Q8N317" "" "" "0" "0" "21.3" "25.4" "23.8" "36.9" "25.9" "21.7" "36.8" "16.7" "24.9" "48.7" "31.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "12" "2" "4" "2" "172" "19.7" "5.00" "1046.43" "3.87" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; SUMOylation of DNA damage response and repair proteins; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "63.2" "60.3" "79.2" "214.6" "115.9" "84.2" "305.7" "170.1" "338.1" "1505.1" "861.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "3" "1" "2" "1" "418" "46.5" "9.29" "399.33" "3.87" "1" "1" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "" "4" "0" "13.0" "16.0" "15.2" "28.4" "12.7" "23.5" "30.3" "16.5" "34.7" "109.6" "122.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYI0" "PH and SEC7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=PSD3 PE=1 SV=2" "2" "1" "1" "1" "1048" "116.0" "5.99" "" "3.85" "" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf01369, Pf15410" "23362" "ENSG00000156011" "PSD3" "A6NFQ4; E9KL50; hsa:23362; Q6B003; Q9NYI0; Q9Y2F1" "" "" "0" "0" "0.0" "0.0" "0.0" "5.6" "0.0" "0.0" "1.6" "0.0" "14.0" "54.7" "49.6" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "11" "1" "2" "1" "97" "11.0" "5.16" "241.47" "3.85" "1" "1" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; hsa:1678; O60220; Q6IRW6" "Mitochondrial protein import" "" "1" "0" "56.2" "50.0" "61.3" "175.1" "94.8" "59.6" "100.1" "57.6" "67.2" "190.0" "157.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "6" "2" "3" "1" "297" "33.2" "6.60" "684.11" "3.84" "2" "1" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Degradation of cysteine and homocysteine" "Trans-sulfuration pathway; Amino acid metabolism" "3" "0" "6.6" "14.7" "16.1" "92.4" "27.1" "4.6" "8.3" "17.1" "10.1" "16.2" "19.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "3" "1" "2" "1" "578" "65.5" "8.21" "489.36" "3.84" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "Mitochondrial tRNA aminoacylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13228" "Methanethiol oxidase OS=Homo sapiens OX=9606 GN=SELENBP1 PE=1 SV=2" "3" "1" "2" "1" "472" "52.4" "6.37" "462.15" "3.84" "1" "1" "transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf05694" "8991" "ENSG00000143416" "SELENBP1" "A6NML9; A6PVW9; B2RDR3; B4DKP6; B4E1F3; hsa:8991; Q13228; Q49AQ8; Q96GX7" "" "IL1 and megakaryocytes in obesity" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "14" "3" "4" "3" "224" "24.9" "4.82" "1236.37" "3.84" "3" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "Sealing of the nuclear envelope (NE) by ESCRT-III; HCMV Late Events; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "348.6" "254.5" "517.8" "1420.2" "825.1" "274.2" "582.3" "486.0" "678.2" "753.6" "453.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3A PE=1 SV=2" "14" "2" "3" "2" "136" "15.3" "11.27" "529.02" "3.83" "2" "1" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Factors involved in megakaryocyte development and platelet production; Estrogen-dependent gene expression; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates transcription of genes involved in differentiation of HSCs; Amyloid fiber formation; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development" "32" "0" "167.3" "152.4" "201.4" "548.0" "261.3" "163.6" "296.1" "172.7" "195.9" "456.5" "334.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "7" "1" "2" "1" "285" "33.0" "5.17" "496.30" "3.82" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52294" "Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3" "3" "1" "2" "1" "538" "60.2" "5.01" "341.82" "3.82" "1" "1" "cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3836" "ENSG00000114030" "KPNA1" "D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56" "Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Interferon alpha/beta signaling; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production" "Ebola virus infection in host" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99848" "Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2" "5" "1" "2" "1" "306" "34.8" "10.10" "479.23" "3.82" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf05890" "10969" "ENSG00000117395" "EBNA1BP2" "hsa:10969; Q96A66; Q99848" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "12" "2" "3" "2" "234" "25.5" "8.51" "987.94" "3.82" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Pyrimidine salvage; G1/S-Specific Transcription" "Fluoropyrimidine activity; Pyrimidine metabolism; 11p11.2 copy number variation syndrome" "5" "0" "80.4" "74.3" "83.5" "195.3" "115.5" "84.1" "150.3" "72.4" "86.9" "232.8" "129.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "2" "1" "2" "1" "582" "64.8" "8.46" "347.47" "3.81" "1" "1" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "6" "0" "19.4" "19.1" "25.1" "64.5" "36.4" "17.7" "36.6" "22.2" "27.6" "108.7" "93.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q93075" "Putative deoxyribonuclease TATDN2 OS=Homo sapiens OX=9606 GN=TATDN2 PE=1 SV=2" "2" "1" "2" "1" "761" "85.0" "7.39" "508.55" "3.81" "1" "1" "" "nucleus" "other molecular function" "Pf01026" "9797" "ENSG00000157014" "TATDN2" "hsa:9797; Q3MIL9; Q5BKU0; Q93075" "XBP1(S) activates chaperone genes" "" "1" "0" "2.3" "0.0" "0.0" "9.7" "4.6" "3.7" "7.9" "10.3" "26.2" "64.8" "44.6" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "2" "1" "2" "1" "953" "107.1" "6.05" "397.04" "3.81" "1" "1" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation; COPI-mediated anterograde transport" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99453" "Paired mesoderm homeobox protein 2B OS=Homo sapiens OX=9606 GN=PHOX2B PE=1 SV=2" "3" "1" "2" "1" "314" "31.6" "8.84" "317.80" "3.80" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "8929" "ENSG00000109132" "PHOX2B" "hsa:8929; Q6PJD9; Q99453" "" "Neural crest differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "0" "16.3" "13.0" "11.8" "23.1" "18.3" "16.9" "29.1" "9.0" "14.5" "37.5" "17.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96ST2" "Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2" "2" "1" "2" "1" "819" "91.9" "4.69" "419.71" "3.80" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "" "Pf08711" "55677" "ENSG00000163166" "IWS1" "hsa:55677; Q2TB65; Q6P157; Q8N3E8; Q96MI7; Q96ST2; Q9NV97; Q9NWH8" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "12.9" "12.7" "16.5" "37.7" "13.1" "10.6" "19.2" "13.0" "12.6" "32.9" "31.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPR0" "Inactive phospholipase C-like protein 2 OS=Homo sapiens OX=9606 GN=PLCL2 PE=1 SV=2" "2" "1" "2" "1" "1127" "125.8" "6.90" "448.87" "3.79" "1" "1" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23228" "ENSG00000154822; ENSG00000284017" "PLCL2" "A8K5V4; hsa:23228; Q8N498; Q9H8L0; Q9UFP9; Q9UPR0" "" "" "0" "0" "0.0" "0.0" "0.0" "3.2" "0.0" "0.0" "2.6" "2.5" "3.9" "47.9" "72.4" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H1E5" "Thioredoxin-related transmembrane protein 4 OS=Homo sapiens OX=9606 GN=TMX4 PE=1 SV=1" "4" "1" "2" "1" "349" "38.9" "4.37" "325.51" "3.77" "1" "1" "" "other membranes;nucleus;other cell component" "other molecular function" "Pf00085" "56255" "ENSG00000125827" "TMX4" "hsa:56255; Q8N4P7; Q8NCC1; Q9H1E5; Q9UJA1; Q9ULQ8" "" "" "0" "0" "11.7" "9.7" "17.6" "78.7" "27.2" "14.8" "21.3" "17.4" "16.8" "37.5" "37.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P206" "Uncharacterized protein KIAA1522 OS=Homo sapiens OX=9606 GN=KIAA1522 PE=1 SV=2" "2" "1" "2" "1" "1035" "107.0" "9.73" "463.49" "3.77" "1" "1" "other biological processes" "" "" "" "57648" "ENSG00000162522" "KIAA1522" "B4DQU8; B5MDY0; C9JH84; hsa:57648; Q8TCQ0; Q9P206" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "1" "" "False" "IsMasterProtein" "O75955" "Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3" "4" "1" "2" "1" "427" "47.3" "7.49" "579.29" "3.76" "1" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "10211" "ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280" "FLOT1" "B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "2" "1" "2" "1" "733" "75.4" "9.32" "366.95" "3.76" "1" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "UCH proteinases" "" "1" "0" "27.5" "26.1" "45.8" "156.4" "59.2" "36.2" "69.0" "38.1" "43.7" "136.0" "120.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HCK8" "Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5" "1" "1" "2" "1" "2581" "290.3" "6.47" "308.52" "3.76" "1" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "57680" "ENSG00000100888" "CHD8" "hsa:57680; Q4G0D8; Q68DQ0; Q6DKH9; Q6P440; Q6ZNL7; Q8N3Z9; Q8NCY4; Q8TBR9; Q96F26; Q9HCK8" "Deactivation of the beta-catenin transactivating complex" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "5" "0" "7.7" "4.7" "8.4" "22.4" "8.0" "4.6" "10.1" "8.1" "9.5" "18.3" "32.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "3" "1" "2" "1" "387" "44.7" "5.60" "408.42" "3.75" "1" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "14.5" "8.8" "22.3" "55.4" "31.3" "14.5" "29.1" "13.4" "20.3" "32.3" "20.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96DE0" "U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2" "8" "1" "2" "1" "195" "21.3" "6.89" "428.05" "3.75" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "131870" "ENSG00000198585" "NUDT16" "B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82" "Phosphate bond hydrolysis by NUDT proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "n/a" "High" "High" "n/a" "n/a" "High" "1" "" "False" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "9" "1" "2" "1" "164" "17.8" "5.03" "346.07" "3.74" "1" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "36.1" "38.4" "55.2" "151.5" "64.5" "40.2" "69.9" "38.1" "51.9" "115.8" "127.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6X9" "ATPase MORC2 OS=Homo sapiens OX=9606 GN=MORC2 PE=1 SV=2" "3" "2" "2" "2" "1032" "117.8" "8.38" "500.21" "3.74" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07496, Pf13589, Pf17942" "22880" "ENSG00000133422" "MORC2" "B2RNB1; hsa:22880; Q9UF28; Q9Y6V2; Q9Y6X9" "Fatty acyl-CoA biosynthesis" "" "1" "0" "23.8" "26.0" "27.6" "73.2" "43.0" "38.6" "68.0" "28.7" "32.1" "183.5" "174.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "3" "1" "2" "1" "478" "50.7" "9.10" "531.87" "3.73" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "21.6" "14.5" "21.3" "48.0" "24.0" "21.6" "31.2" "15.0" "31.7" "92.8" "119.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "5" "1" "2" "1" "245" "26.4" "6.52" "401.00" "3.73" "1" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "29.6" "22.0" "29.8" "72.8" "46.7" "37.6" "51.3" "37.6" "46.1" "173.5" "152.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRQ6" "MICOS complex subunit MIC25 OS=Homo sapiens OX=9606 GN=CHCHD6 PE=1 SV=1" "5" "1" "2" "1" "235" "26.4" "8.85" "382.14" "3.72" "1" "1" "cell organization and biogenesis;stress response" "other membranes;cytosol;mitochondrion" "" "Pf05300" "84303" "ENSG00000159685" "CHCHD6" "D6R9U0; D6RIB4; H8Y0Y7; hsa:84303; Q9BRQ6" "Cristae formation" "" "1" "0" "9.2" "8.9" "8.0" "42.0" "15.3" "5.1" "11.7" "14.3" "15.7" "45.5" "39.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9C0B0" "RING finger protein unkempt homolog OS=Homo sapiens OX=9606 GN=UNK PE=1 SV=2" "1" "1" "2" "1" "810" "88.0" "6.86" "408.63" "3.72" "1" "1" "developmental processes;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf18384" "85451" "ENSG00000132478" "UNK" "hsa:85451; Q9C0B0" "" "" "0" "0" "22.0" "16.1" "22.8" "53.5" "28.8" "14.7" "30.5" "23.3" "24.4" "48.7" "37.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95983" "Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1" "4" "1" "2" "1" "291" "32.8" "5.34" "441.99" "3.72" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "53615" "ENSG00000071655" "MBD3" "A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome" "7" "0" "124.9" "114.7" "141.8" "439.2" "186.9" "93.3" "133.2" "126.5" "94.3" "180.9" "149.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "3" "1" "2" "1" "380" "42.1" "5.63" "369.18" "3.72" "1" "1" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "11.9" "10.2" "17.0" "65.3" "28.2" "10.4" "17.3" "9.9" "10.0" "37.4" "41.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "1" "1" "2" "1" "798" "88.8" "6.25" "415.66" "3.70" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "104.5" "86.1" "127.5" "513.2" "192.6" "79.0" "168.1" "92.7" "92.7" "228.6" "154.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRD0" "BUD13 homolog OS=Homo sapiens OX=9606 GN=BUD13 PE=1 SV=1" "2" "1" "2" "1" "619" "70.5" "9.86" "425.80" "3.70" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf09736" "84811" "ENSG00000137656" "BUD13" "A8K0S0; hsa:84811; Q96LS7; Q9BRD0" "mRNA Splicing - Major Pathway" "" "1" "0" "5.5" "6.3" "7.3" "14.9" "10.6" "5.0" "9.5" "6.3" "9.2" "39.5" "32.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P32780" "General transcription factor IIH subunit 1 OS=Homo sapiens OX=9606 GN=GTF2H1 PE=1 SV=1" "4" "2" "3" "2" "548" "62.0" "8.66" "658.42" "3.69" "2" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03909, Pf08567" "2965" "ENSG00000110768; ENSG00000288114" "GTF2H1" "B3KXE0; D3DQY2; hsa:2965; P32780; Q6I9Y7; Q9H5K5; Q9NQD9" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "33" "0" "49.9" "36.8" "54.5" "98.5" "63.2" "41.3" "110.2" "83.8" "220.4" "536.8" "419.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "3" "1" "2" "1" "455" "51.8" "6.35" "359.54" "3.69" "1" "1" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "57.4" "65.2" "82.8" "384.8" "148.2" "48.9" "72.5" "64.6" "55.7" "180.9" "140.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "6" "1" "2" "1" "198" "21.7" "5.59" "303.33" "3.68" "1" "1" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13405, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "" "5" "0" "13.2" "18.1" "23.4" "157.0" "54.3" "9.1" "21.5" "27.3" "25.8" "36.8" "31.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "1" "1" "2" "1" "1332" "150.2" "5.94" "359.64" "3.68" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HATs acetylate histones" "" "1" "0" "23.5" "18.7" "29.1" "60.7" "40.2" "25.0" "42.1" "18.6" "32.1" "94.6" "89.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99633" "Pre-mRNA-splicing factor 18 OS=Homo sapiens OX=9606 GN=PRPF18 PE=1 SV=1" "6" "2" "3" "2" "342" "39.8" "8.15" "836.04" "3.67" "2" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02840, Pf08799" "8559" "ENSG00000165630" "PRPF18" "hsa:8559; Q5T9P9; Q99633; Q9BUI9" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "56.5" "48.3" "70.4" "161.2" "91.4" "64.6" "148.5" "77.0" "143.8" "830.0" "730.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BYD3" "39S ribosomal protein L4, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" "5" "1" "2" "1" "311" "34.9" "9.72" "366.22" "3.67" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00573" "51073" "ENSG00000105364" "MRPL4" "A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "39.8" "36.0" "43.2" "160.8" "58.2" "30.1" "64.3" "42.0" "58.8" "265.5" "259.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96T60" "Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1" "3" "1" "2" "1" "521" "57.0" "8.46" "424.93" "3.66" "1" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf08645, Pf13671, Pf17913" "11284" "ENSG00000039650" "PNKP" "hsa:11284; Q96T60; Q9BUL2; Q9P1V2; Q9UKU8; Q9UNF8; Q9UNI0" "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" "Base excision repair; DNA repair pathways, full network" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "4" "2" "3" "2" "492" "54.1" "6.38" "554.68" "3.66" "2" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Intraflagellar transport proteins binding to dynein" "13" "0" "104.4" "89.2" "109.7" "259.6" "152.2" "99.5" "161.8" "70.6" "101.0" "217.5" "145.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P56385" "ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2" "26" "3" "4" "2" "69" "7.9" "9.35" "916.29" "3.66" "3" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05680" "521" "ENSG00000169020" "ATP5ME" "hsa:521; P56385; Q0D2L9" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "92.4" "87.2" "123.4" "279.4" "157.1" "99.0" "169.6" "105.7" "120.7" "285.4" "231.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43572" "A-kinase anchor protein 10, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP10 PE=1 SV=2" "2" "1" "2" "1" "662" "73.8" "6.39" "379.89" "3.66" "1" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00615" "11216" "ENSG00000108599" "AKAP10" "B2R650; hsa:11216; O43572; Q96AJ7" "Factors involved in megakaryocyte development and platelet production" "G protein signaling pathways" "2" "0" "28.2" "16.4" "22.9" "26.4" "29.3" "18.3" "35.9" "26.0" "27.3" "23.9" "9.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "5" "1" "2" "1" "278" "29.5" "8.56" "481.74" "3.66" "1" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "Peroxisomal protein import; RA biosynthesis pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "5" "1" "2" "1" "275" "29.7" "6.80" "346.30" "3.65" "1" "1" "transport" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "" "3" "0" "18.3" "17.1" "20.3" "50.1" "35.7" "21.9" "54.7" "58.5" "100.7" "221.0" "164.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "4" "1" "2" "1" "306" "32.4" "9.17" "310.30" "3.65" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "22.9" "28.1" "39.1" "145.8" "60.6" "17.2" "57.5" "38.2" "35.9" "114.5" "87.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15104" "Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4" "6" "1" "1" "1" "373" "42.0" "6.89" "" "3.65" "" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00120, Pf03951" "2752" "ENSG00000135821" "GLUL" "hsa:2752; P15104; Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17" "Glutamate and glutamine metabolism; Astrocytic Glutamate-Glutamine Uptake And Metabolism" "TNF-alpha signaling pathway; Amino acid metabolism" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "High" "High" "High" "n/a" "1" "" "False" "IsMasterProtein" "Q16527" "Cysteine and glycine-rich protein 2 OS=Homo sapiens OX=9606 GN=CSRP2 PE=1 SV=3" "7" "1" "2" "1" "193" "20.9" "8.62" "460.63" "3.64" "1" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1466" "ENSG00000175183" "CSRP2" "hsa:1466; Q16527; Q93030" "" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity" "3" "0" "19.1" "15.0" "21.4" "38.9" "26.9" "21.2" "29.5" "13.5" "19.8" "36.3" "32.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12846" "Syntaxin-4 OS=Homo sapiens OX=9606 GN=STX4 PE=1 SV=2" "4" "1" "2" "1" "297" "34.2" "6.28" "329.34" "3.64" "1" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00804, Pf05739" "6810" "ENSG00000103496" "STX4" "A8MXY0; hsa:6810; Q12846; Q15525; Q6FHE8" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; ER-Phagosome pathway; trans-Golgi Network Vesicle Budding; Disinhibition of SNARE formation; Other interleukin signaling" "Insulin signaling" "6" "0" "5.5" "8.2" "9.4" "34.3" "11.2" "4.5" "10.3" "11.2" "5.7" "22.0" "28.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "11" "1" "2" "1" "112" "12.5" "4.78" "272.21" "3.64" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; 11p11.2 copy number variation syndrome" "22" "0" "26.2" "25.0" "27.9" "94.2" "42.9" "23.1" "42.3" "40.1" "80.9" "524.0" "657.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14139" "Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2" "1" "1" "2" "1" "1066" "122.5" "5.24" "296.78" "3.63" "1" "1" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "9354" "ENSG00000110344" "UBE4A" "B0YJB6; hsa:9354; Q14139; Q2M1H0; Q6P5T4; Q7Z639" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "28.6" "20.6" "38.4" "138.1" "61.2" "38.6" "62.7" "42.7" "35.8" "112.6" "91.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "5" "1" "2" "1" "332" "37.5" "7.87" "383.54" "3.62" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "34.0" "40.9" "65.9" "375.2" "117.4" "36.5" "62.0" "60.5" "53.6" "96.4" "107.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "1" "1" "2" "1" "944" "103.0" "6.07" "509.89" "3.61" "1" "1" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181, Pf13432" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "14.3" "15.6" "28.3" "89.4" "34.6" "18.5" "42.2" "20.4" "27.7" "85.7" "83.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "4" "1" "2" "1" "390" "42.9" "8.72" "365.97" "3.60" "1" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; hsa:27349; O95510; O95511; Q8IVS2" "Mitochondrial Fatty Acid Beta-Oxidation" "Mitochondrial fatty acid synthesis pathway" "2" "0" "21.8" "34.8" "44.8" "95.1" "56.9" "44.5" "79.7" "37.8" "64.0" "181.8" "160.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96L58" "Beta-1,3-galactosyltransferase 6 OS=Homo sapiens OX=9606 GN=B3GALT6 PE=1 SV=2" "4" "1" "2" "1" "329" "37.1" "9.66" "481.86" "3.60" "1" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf01762" "126792" "ENSG00000176022" "B3GALT6" "hsa:126792; Q5T7M5; Q96L58" "A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GALT6 causes EDSP2 and SEMDJL1" "Proteoglycan biosynthesis; 1p36 copy number variation syndrome" "4" "0" "9.8" "10.5" "11.5" "39.8" "20.9" "16.1" "21.9" "14.4" "11.5" "30.3" "26.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "2" "1" "2" "1" "401" "44.2" "5.21" "349.32" "3.60" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "11" "0" "55.6" "58.0" "66.9" "204.4" "103.5" "59.9" "98.0" "56.9" "78.9" "266.5" "259.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P4R8" "Nuclear factor related to kappa-B-binding protein OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=2" "1" "1" "2" "1" "1299" "138.9" "9.25" "294.16" "3.60" "1" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf14465" "4798" "ENSG00000170322" "NFRKB" "hsa:4798; Q12869; Q15312; Q6P4R8; Q9H048" "UCH proteinases; DNA Damage Recognition in GG-NER" "Overview of nanoparticle effects" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "1" "1" "2" "1" "826" "92.4" "5.96" "284.66" "3.59" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; hsa:55250; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "HATs acetylate histones" "" "1" "0" "2.7" "4.1" "6.4" "25.1" "11.4" "7.7" "12.8" "4.9" "4.2" "54.1" "58.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92506" "Estradiol 17-beta-dehydrogenase 8 OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "5" "1" "2" "1" "261" "27.0" "6.54" "331.13" "3.58" "1" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "Fatty acyl-CoA biosynthesis" "" "1" "0" "27.1" "27.4" "39.1" "67.4" "39.9" "36.8" "73.3" "34.5" "35.1" "133.6" "132.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3D3" "28S ribosomal protein S16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "9" "1" "2" "1" "137" "15.3" "9.50" "408.24" "3.58" "1" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "54.9" "55.5" "82.3" "283.3" "120.2" "77.4" "119.3" "89.7" "97.7" "306.3" "246.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "1" "1" "2" "1" "1058" "120.0" "6.04" "295.24" "3.57" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "" "2" "0" "10.9" "10.3" "17.0" "46.4" "27.2" "10.4" "24.4" "18.6" "23.1" "57.3" "63.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "1" "1" "2" "1" "1438" "162.1" "5.36" "286.00" "3.57" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4Y9" "U6 snRNA-associated Sm-like protein LSm5 OS=Homo sapiens OX=9606 GN=LSM5 PE=1 SV=3" "25" "1" "1" "1" "91" "9.9" "4.54" "" "3.57" "" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "23658" "ENSG00000106355" "LSM5" "hsa:23658; Q9Y4Y9" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "3.3" "3.9" "9.6" "17.1" "10.4" "8.5" "7.6" "6.7" "12.5" "20.0" "20.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "2" "1" "2" "1" "1059" "112.1" "7.30" "336.07" "3.57" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "n/a" "High" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 homolog OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "1" "1" "2" "1" "1749" "195.9" "6.73" "333.02" "3.56" "1" "1" "transport" "cytosol;nucleus" "other molecular function" "Pf10487" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "Vpr-mediated nuclear import of PICs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of chromatin organization proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IYU8" "Calcium uptake protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=MICU2 PE=1 SV=2" "4" "1" "2" "1" "434" "49.6" "9.09" "321.01" "3.56" "1" "1" "transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13833" "221154" "ENSG00000165487" "MICU2" "hsa:221154; Q8IYU8; Q8N0T6; Q8NAX8" "Processing of SMDT1" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "3" "1" "2" "1" "374" "42.5" "5.63" "356.64" "3.55" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "" "6" "0" "15.7" "18.4" "29.4" "131.7" "54.5" "24.3" "57.7" "28.1" "30.7" "197.6" "158.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N300" "Small vasohibin-binding protein OS=Homo sapiens OX=9606 GN=SVBP PE=1 SV=1" "23" "1" "2" "1" "66" "7.8" "9.16" "353.62" "3.55" "1" "1" "cell organization and biogenesis;protein metabolism;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf15674" "374969" "ENSG00000177868" "SVBP" "A8K5P1; D3DPW7; hsa:374969; Q8N300" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "18.4" "21.2" "28.0" "69.6" "34.6" "26.0" "49.1" "40.3" "104.9" "259.5" "175.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "3" "1" "2" "1" "463" "52.5" "7.55" "251.27" "3.54" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "35.6" "37.4" "48.3" "143.1" "73.9" "43.1" "58.5" "36.6" "49.1" "168.1" "173.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "6" "1" "2" "1" "205" "22.9" "4.63" "312.64" "3.54" "1" "1" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "Neutrophil degranulation" "" "1" "0" "24.8" "33.2" "46.5" "292.3" "80.7" "14.3" "12.5" "34.0" "25.3" "30.1" "50.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12767" "Transmembrane protein 94 OS=Homo sapiens OX=9606 GN=TMEM94 PE=1 SV=1" "1" "1" "2" "1" "1356" "151.1" "6.44" "424.43" "3.53" "1" "1" "" "other membranes" "" "" "9772" "ENSG00000177728" "TMEM94" "C9JL75; hsa:9772; O75536; Q12767; Q86XF1" "" "" "0" "0" "8.6" "4.7" "10.3" "23.4" "14.2" "5.5" "22.7" "15.8" "19.9" "221.0" "311.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6NUM9" "All-trans-retinol 13,14-reductase OS=Homo sapiens OX=9606 GN=RETSAT PE=1 SV=2" "3" "1" "2" "1" "610" "66.8" "8.28" "417.42" "3.53" "1" "1" "other metabolic processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf13450" "54884" "ENSG00000042445" "RETSAT" "A6NIK3; hsa:54884; Q53R95; Q53SA9; Q6NUM9; Q6UX05; Q8N2H5; Q96FA4; Q9NXE5" "Retinoid metabolism and transport" "Vitamin A and carotenoid metabolism" "2" "0" "0.0" "0.0" "0.0" "5.3" "2.2" "0.0" "2.3" "4.4" "8.0" "55.0" "55.6" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62875" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" "16" "1" "3" "1" "67" "7.6" "7.77" "810.26" "3.53" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01194" "5441" "ENSG00000177700" "POLR2L" "hsa:5441; P52436; P62875; Q6FHX3" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "56" "0" "39.7" "27.3" "43.7" "129.3" "55.4" "40.4" "78.0" "70.0" "155.1" "597.3" "476.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "2" "2" "3" "2" "968" "112.1" "6.95" "809.28" "3.52" "2" "1" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "" "4" "0" "33.0" "29.1" "36.0" "95.6" "41.0" "24.0" "57.3" "45.1" "68.9" "358.7" "324.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "2" "1" "2" "1" "469" "51.3" "5.58" "352.38" "3.52" "1" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "25" "0" "21.6" "23.5" "34.9" "107.4" "52.3" "29.2" "56.5" "51.4" "80.6" "246.4" "204.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "5" "1" "2" "1" "188" "20.8" "9.66" "398.84" "3.52" "1" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "" "2" "0" "29.4" "24.3" "39.1" "184.2" "65.1" "26.7" "66.8" "46.2" "66.7" "338.1" "326.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "1" "1" "2" "1" "1817" "197.5" "6.40" "487.14" "3.51" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "1" "0" "119.5" "102.4" "135.7" "225.4" "161.0" "116.8" "179.2" "82.2" "129.4" "256.9" "200.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NFX7" "Syntaxin-binding protein 6 OS=Homo sapiens OX=9606 GN=STXBP6 PE=1 SV=2" "7" "1" "2" "1" "210" "23.5" "9.04" "276.63" "3.50" "1" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cell component" "" "Pf00957, Pf15277" "29091" "ENSG00000168952" "STXBP6" "D3DS78; hsa:29091; Q8N3H1; Q8N8D5; Q8NFX7; Q96GF3; Q9P008" "" "" "0" "0" "23.9" "16.3" "28.4" "87.6" "38.5" "32.8" "109.6" "87.7" "177.9" "439.3" "329.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "3" "1" "2" "1" "329" "35.2" "8.44" "360.57" "3.50" "1" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "101.9" "81.6" "96.9" "243.4" "109.4" "80.7" "120.1" "52.9" "72.8" "173.7" "139.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "6" "2" "3" "2" "341" "39.8" "6.89" "661.10" "3.50" "2" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "6" "0" "143.7" "158.4" "182.4" "630.5" "244.8" "92.6" "190.8" "126.6" "245.9" "1194.8" "914.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2Q5" "Ragulator complex protein LAMTOR2 OS=Homo sapiens OX=9606 GN=LAMTOR2 PE=1 SV=1" "14" "1" "1" "1" "125" "13.5" "5.40" "" "3.50" "" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf03259" "28956" "ENSG00000116586" "LAMTOR2" "hsa:28956; Q5VY97; Q5VY98; Q5VY99; Q9Y2Q5" "Neutrophil degranulation; MAP2K and MAPK activation; Amino acids regulate mTORC1; Macroautophagy; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK" "" "9" "0" "12.5" "13.6" "14.3" "30.5" "23.9" "10.1" "21.8" "13.9" "15.6" "43.3" "37.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H5V9" "UPF0428 protein CXorf56 OS=Homo sapiens OX=9606 GN=CXorf56 PE=1 SV=1" "6" "1" "2" "1" "222" "25.6" "8.73" "398.10" "3.49" "1" "1" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "mRNA Splicing - Major Pathway" "" "1" "0" "66.4" "50.3" "66.6" "113.7" "73.4" "50.0" "93.5" "45.1" "87.0" "282.2" "197.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T7V8" "RAB6-interacting golgin OS=Homo sapiens OX=9606 GN=GORAB PE=1 SV=1" "5" "1" "2" "1" "394" "45.0" "7.08" "297.29" "3.49" "1" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "n/a" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60870" "DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2" "3" "1" "2" "1" "393" "45.3" "8.95" "424.24" "3.49" "1" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10357, Pf18131" "22944" "ENSG00000151657" "KIN" "B4DX32; hsa:22944; O60870" "Protein methylation" "" "1" "0" "5.2" "4.0" "3.5" "13.6" "7.8" "3.4" "5.3" "12.5" "5.2" "22.2" "45.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08195" "4F2 cell-surface antigen heavy chain OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "2" "1" "2" "1" "630" "68.0" "5.01" "513.75" "3.49" "1" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "8" "0" "12.4" "16.8" "21.0" "87.9" "40.5" "9.9" "20.8" "19.5" "17.4" "53.7" "69.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35030" "Trypsin-3 OS=Homo sapiens OX=9606 GN=PRSS3 PE=1 SV=2" "4" "1" "2" "1" "304" "32.5" "7.49" "315.92" "3.49" "1" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00089" "5646" "ENSG00000010438" "PRSS3" "A8CED1; A8CED3; A9Z1Y4; E7ES07; F8W7P3; hsa:5646; P15951; P35030; Q15665; Q5VXV0; Q6ISJ4; Q9UQV3" "Neutrophil degranulation; Uptake of dietary cobalamins into enterocytes; Antimicrobial peptides; Alpha-defensins" "" "4" "0" "65.7" "67.7" "95.2" "152.0" "95.7" "68.4" "105.8" "70.9" "111.5" "274.0" "229.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "5" "1" "2" "1" "370" "40.5" "5.10" "230.88" "3.49" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "RHOH GTPase cycle" "Alstrom syndrome" "2" "0" "59.1" "49.1" "76.6" "290.5" "123.3" "49.5" "38.9" "76.9" "52.7" "34.1" "43.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78324" "Tyrosine-protein phosphatase non-receptor type substrate 1 OS=Homo sapiens OX=9606 GN=SIRPA PE=1 SV=2" "3" "1" "2" "1" "504" "54.9" "6.98" "423.48" "3.49" "1" "1" "cell adhesion;stress response;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf07654, Pf07686" "140885" "ENSG00000198053" "SIRPA" "A2A2E1; A8K411; B2R6C3; hsa:140885; O00683; O43799; P78324; Q8N517; Q8TAL8; Q9H0Z2; Q9UDX2; Q9UIJ6; Q9Y4U9" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions" "Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "4" "1" "2" "1" "368" "41.5" "5.43" "442.91" "3.49" "1" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "Fragile X syndrome" "6" "0" "6.2" "8.6" "18.0" "104.6" "24.6" "4.5" "20.6" "18.0" "11.5" "51.5" "63.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23786" "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2" "2" "1" "2" "1" "658" "73.7" "8.18" "435.62" "3.48" "1" "1" "other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00755" "1376" "ENSG00000157184" "CPT2" "B2R6S0; hsa:1376; P23786; Q5SW68; Q9BQ26" "PPARA activates gene expression; Carnitine metabolism" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis; Mitochondrial fatty acid oxidation disorders" "9" "0" "7.9" "6.1" "6.3" "31.1" "8.0" "5.0" "7.9" "7.0" "7.2" "30.3" "22.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96P16" "Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1" "4" "1" "2" "1" "312" "35.7" "7.55" "390.66" "3.48" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "55197" "ENSG00000141425" "RPRD1A" "A8KA42; B2RBA3; hsa:55197; Q7Z5G8; Q96FY9; Q96P16; Q9NVL4" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "9.1" "11.7" "10.8" "70.0" "22.2" "2.6" "17.2" "13.9" "14.3" "65.9" "151.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "2" "1" "2" "1" "642" "72.9" "5.87" "325.89" "3.48" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "16.4" "18.6" "25.9" "80.9" "35.6" "22.2" "36.6" "22.2" "41.1" "130.8" "104.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BY89" "Uncharacterized protein KIAA1671 OS=Homo sapiens OX=9606 GN=KIAA1671 PE=1 SV=2" "1" "1" "2" "1" "1806" "196.6" "8.47" "501.16" "3.47" "1" "1" "" "" "" "Pf15327" "85379" "ENSG00000197077" "KIAA1671" "B0QYF2; B7ZW08; hsa:85379; Q5THZ5; Q9BY89" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "3" "1" "2" "1" "478" "52.9" "5.82" "331.48" "3.47" "1" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "15.5" "13.1" "17.6" "61.8" "25.9" "11.0" "29.9" "19.5" "27.1" "81.7" "137.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "3" "1" "2" "1" "459" "50.9" "4.73" "301.78" "3.47" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "16.2" "13.8" "22.0" "68.5" "35.6" "18.5" "31.9" "14.9" "18.6" "35.2" "28.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "6" "2" "3" "2" "406" "46.9" "8.37" "639.67" "3.47" "2" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "" "2" "0" "96.3" "65.4" "115.8" "219.6" "131.1" "101.1" "147.6" "76.6" "123.3" "347.6" "327.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "1" "1" "2" "1" "1273" "145.1" "7.25" "425.74" "3.47" "1" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; hsa:25942; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; NoRC negatively regulates rRNA expression; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by PPARalpha; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway" "17" "0" "40.7" "34.5" "52.9" "122.3" "63.2" "28.6" "70.8" "37.8" "40.6" "94.1" "50.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQX3" "Gephyrin OS=Homo sapiens OX=9606 GN=GPHN PE=1 SV=1" "3" "1" "2" "1" "736" "79.7" "5.43" "271.13" "3.47" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00994, Pf03453, Pf03454" "10243" "ENSG00000171723" "GPHN" "hsa:10243; Q96KU4; Q9H4E9; Q9NQX3; Q9P2G2" "Molybdenum cofactor biosynthesis" "Splicing factor NOVA regulated synaptic proteins; GABA receptor signaling; Fragile X syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "2" "2" "3" "2" "917" "102.4" "6.80" "701.70" "3.46" "2" "1" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "11" "0" "31.3" "22.6" "38.4" "127.6" "47.6" "12.9" "37.4" "25.4" "21.1" "63.0" "98.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "1" "2" "3" "2" "1792" "201.4" "9.64" "577.67" "3.46" "2" "1" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "hsa:5930; Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "RHOBTB1 GTPase cycle; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "39.6" "26.8" "48.2" "88.2" "59.7" "35.4" "71.1" "26.4" "44.3" "122.7" "106.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "2" "1" "2" "1" "426" "46.6" "8.05" "397.88" "3.45" "1" "1" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Branched-chain amino acid catabolism" "Valproic acid pathway" "2" "0" "101.9" "113.1" "141.3" "414.6" "168.6" "88.8" "177.8" "94.6" "105.7" "320.8" "239.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2PPJ7" "Ral GTPase-activating protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=RALGAPA2 PE=1 SV=2" "1" "2" "3" "1" "1873" "210.6" "6.07" "575.91" "3.45" "2" "1" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf20412" "57186" "ENSG00000188559" "RALGAPA2" "hsa:57186; Q2PPJ7; Q4VXU6; Q5JUA3; Q5JUA4; Q5T9K3; Q96CX9; Q9BQT7; Q9H9D9; Q9ULE8" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "3.4" "0.0" "0.0" "8.9" "4.9" "2.0" "4.5" "6.5" "7.5" "34.1" "42.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "4" "1" "2" "1" "276" "30.0" "5.30" "316.49" "3.45" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "13.6" "11.9" "16.3" "75.1" "31.3" "9.5" "28.7" "17.8" "12.6" "100.3" "86.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "3" "1" "1" "1" "318" "35.2" "8.94" "" "3.44" "" "1" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Neutrophil degranulation; Pentose phosphate pathway" "Pentose phosphate pathway in senescent cells" "3" "0" "131.0" "120.6" "153.5" "264.6" "198.5" "138.1" "234.0" "128.3" "174.6" "420.5" "354.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14247" "Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2" "2" "1" "2" "1" "550" "61.5" "5.40" "235.99" "3.43" "1" "1" "cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf02218, Pf14604" "2017" "ENSG00000085733; ENSG00000288401" "CTTN" "hsa:2017; Q14247; Q8N707; Q96H99" "Clathrin-mediated endocytosis; RHO GTPases activate PAKs" "Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma" "4" "0" "26.5" "31.2" "38.8" "107.0" "57.6" "30.2" "52.0" "30.4" "39.3" "124.1" "115.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49642" "DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1" "3" "1" "2" "1" "420" "49.9" "8.21" "337.52" "3.43" "1" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01896" "5557" "ENSG00000198056" "PRIM1" "hsa:5557; P49642" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "13" "0" "61.3" "54.6" "71.0" "337.8" "116.4" "76.8" "142.5" "76.2" "76.7" "267.3" "241.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "2" "1" "2" "1" "718" "81.0" "7.30" "362.01" "3.43" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "Mitochondrial tRNA aminoacylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "5" "2" "2" "2" "397" "41.9" "8.09" "253.46" "3.42" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Mitochondrial Fatty Acid Beta-Oxidation" "Fatty acid biosynthesis; 10q11.21q11.23 copy number variation syndrome" "3" "0" "73.3" "54.8" "96.1" "240.0" "115.4" "59.2" "140.8" "79.7" "141.2" "560.7" "637.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZL4" "Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1" "2" "1" "2" "1" "782" "84.8" "5.57" "417.21" "3.42" "1" "1" "signal transduction" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf12796, Pf15898" "54776" "ENSG00000125503" "PPP1R12C" "B4DME2; hsa:54776; Q59FK8; Q6ZPD1; Q7L8F7; Q96HW1; Q9BZL4; Q9H5H5; Q9NT00" "" "Focal adhesion" "1" "0" "5.8" "3.4" "6.1" "17.2" "8.4" "8.5" "9.4" "3.8" "6.0" "57.7" "50.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NB49" "Phospholipid-transporting ATPase IG OS=Homo sapiens OX=9606 GN=ATP11C PE=1 SV=3" "1" "1" "2" "1" "1132" "129.4" "6.67" "341.93" "3.42" "1" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf13246, Pf16209, Pf16212" "286410" "ENSG00000101974" "ATP11C" "hsa:286410; Q5JT69; Q5JT70; Q5JT71; Q5JT72; Q5JT73; Q6ZND5; Q6ZU50; Q6ZUP7; Q70IJ9; Q70IK0; Q8NB49; Q8WX24" "Ion transport by P-type ATPases" "Complement system in neuronal development and plasticity" "2" "0" "6.6" "6.7" "16.1" "48.6" "18.1" "9.1" "12.2" "9.3" "12.3" "44.1" "34.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BT25" "HAUS augmin-like complex subunit 8 OS=Homo sapiens OX=9606 GN=HAUS8 PE=1 SV=3" "6" "1" "1" "1" "410" "44.8" "7.06" "" "3.41" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "93323" "ENSG00000131351" "HAUS8" "B4DJA7; C9JBZ4; hsa:93323; Q49AC4; Q86WF0; Q96FX3; Q9BT25" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "3" "1" "2" "1" "323" "37.6" "7.15" "336.73" "3.41" "1" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "39" "0" "4.8" "8.0" "10.5" "41.8" "16.3" "11.3" "21.2" "13.7" "17.0" "105.5" "115.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRX1" "RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1" "7" "1" "2" "1" "252" "27.9" "9.73" "397.63" "3.39" "1" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "" "56902" "ENSG00000115946" "PNO1" "A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P11274" "Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2" "1" "1" "2" "1" "1271" "142.7" "7.03" "344.31" "3.39" "1" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00168, Pf00620, Pf00621, Pf09036, Pf19057" "613" "ENSG00000186716" "BCR" "hsa:613; P11274; P78501; Q12842; Q4LE80; Q6NZI3" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "Imatinib and chronic myeloid leukemia; Extrafollicular and follicular B cell activation by SARS-CoV-2" "11" "0" "2.4" "3.6" "7.2" "22.5" "6.8" "1.9" "4.4" "8.5" "27.9" "194.2" "256.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12768" "WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1" "1" "1" "2" "1" "1159" "134.2" "6.98" "409.85" "3.39" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf10266" "9897" "ENSG00000164961" "WASHC5" "A8K4R7; hsa:9897; Q12768; Q3KQX5; Q8TBQ2" "" "" "0" "0" "20.6" "23.8" "32.0" "70.4" "44.6" "35.9" "58.1" "31.0" "40.3" "97.6" "100.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "6" "1" "2" "1" "286" "32.9" "5.85" "364.71" "3.39" "1" "1" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "7" "0" "5.5" "7.3" "7.8" "39.4" "12.7" "6.6" "14.0" "6.7" "6.3" "51.1" "54.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "6" "1" "1" "1" "365" "41.0" "5.16" "" "3.38" "" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "n/a" "High" "n/a" "n/a" "n/a" "High" "1" "" "False" "IsMasterProtein" "Q9NZW5" "MAGUK p55 subfamily member 6 OS=Homo sapiens OX=9606 GN=MPP6 PE=1 SV=2" "2" "1" "2" "1" "540" "61.1" "6.18" "313.45" "3.38" "1" "1" "cell organization and biogenesis" "plasma membrane;other membranes;other cell component" "" "Pf00595, Pf00625, Pf02828, Pf07653" "51678" "ENSG00000105926" "PALS2" "A4D157; hsa:51678; Q9H0E1; Q9NZW5" "" "" "0" "0" "13.4" "13.2" "18.0" "65.2" "18.9" "10.4" "26.6" "12.7" "14.8" "61.3" "69.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "5" "1" "2" "1" "225" "24.3" "7.94" "383.35" "3.38" "1" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "Ciliary landscape" "3" "0" "30.2" "26.3" "46.2" "178.1" "78.8" "35.1" "59.8" "43.9" "34.9" "110.3" "94.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "4" "2" "3" "2" "572" "61.2" "6.67" "590.31" "3.38" "2" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "" "Integrin-mediated cell adhesion; Focal adhesion" "2" "0" "172.6" "159.4" "223.1" "458.7" "239.9" "151.0" "266.5" "149.4" "166.3" "372.0" "252.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "4" "1" "2" "1" "306" "32.7" "5.06" "468.33" "3.37" "1" "1" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing" "mRNA processing" "6" "0" "60.9" "41.2" "58.7" "294.1" "114.8" "37.4" "83.2" "42.8" "46.9" "155.5" "110.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5C9Z4" "Nucleolar MIF4G domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOM1 PE=1 SV=1" "2" "1" "2" "1" "860" "96.2" "8.10" "396.94" "3.37" "1" "1" "other biological processes" "nucleus" "" "Pf02847, Pf02854" "64434" "ENSG00000146909" "NOM1" "hsa:64434; Q5C9Z4; Q96I08" "" "" "0" "0" "27.0" "22.8" "35.6" "65.5" "55.9" "22.3" "48.5" "20.6" "24.4" "62.7" "47.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96EY1" "DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2" "5" "1" "1" "1" "480" "52.5" "9.26" "" "3.37" "" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00226, Pf00684, Pf01556" "9093" "ENSG00000103423; ENSG00000276726" "DNAJA3" "B2RAJ5; B4DI33; E7ES32; hsa:9093; O75472; Q8WUJ6; Q8WXJ3; Q96D76; Q96EY1; Q96IV1; Q9NYH8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P67812" "Signal peptidase complex catalytic subunit SEC11A OS=Homo sapiens OX=9606 GN=SEC11A PE=1 SV=1" "7" "1" "2" "1" "179" "20.6" "9.48" "283.72" "3.36" "1" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00717" "23478" "ENSG00000140612" "SEC11A" "B2RAD7; B4DUL4; H0YK72; H0YK83; hsa:23478; O75957; P21378; P67812; Q53FQ8" "SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin" "" "4" "0" "84.6" "83.9" "114.1" "381.6" "166.2" "92.8" "154.5" "87.2" "113.0" "329.1" "289.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NBL1" "Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1" "3" "1" "2" "1" "392" "46.2" "8.72" "299.11" "3.36" "1" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf05686" "56983" "ENSG00000163389" "POGLUT1" "B2RD13; hsa:56983; Q53GJ4; Q8N2T1; Q8NBL1" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "" "1" "0" "15.2" "18.9" "25.1" "52.6" "27.6" "23.4" "36.4" "23.1" "25.5" "133.1" "147.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "5" "1" "2" "1" "285" "33.3" "5.86" "302.61" "3.36" "1" "1" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "30.8" "29.1" "36.2" "89.6" "44.6" "36.3" "56.4" "29.9" "53.6" "122.9" "76.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "5" "1" "2" "1" "240" "26.7" "5.20" "331.94" "3.35" "1" "1" "" "other membranes" "other molecular function" "Pf13499" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "RHOD GTPase cycle" "" "1" "0" "40.1" "25.6" "49.0" "222.7" "70.2" "29.5" "65.5" "33.5" "40.5" "114.3" "94.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "6" "1" "2" "1" "222" "24.7" "8.25" "327.68" "3.35" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; hsa:6648; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "10" "0" "26.9" "28.2" "42.4" "136.9" "61.1" "29.6" "51.3" "39.8" "42.1" "106.2" "85.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "2" "1" "2" "1" "904" "98.6" "8.40" "374.20" "3.33" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "enzyme regulator activity;translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "19.8" "22.3" "25.4" "58.2" "42.1" "21.8" "33.3" "19.8" "32.1" "123.3" "103.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53677" "AP-3 complex subunit mu-2 OS=Homo sapiens OX=9606 GN=AP3M2 PE=1 SV=1" "2" "1" "2" "1" "418" "46.9" "7.56" "328.13" "3.33" "1" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf00928, Pf01217" "10947" "ENSG00000070718" "AP3M2" "B2RCR0; D3DSY2; hsa:10947; P53677; Q7Z472" "" "" "0" "0" "21.1" "15.3" "24.6" "48.9" "29.9" "26.8" "32.8" "13.1" "28.6" "101.8" "87.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H4B0" "Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OSGEPL1 PE=2 SV=2" "4" "1" "2" "1" "414" "45.1" "8.56" "367.93" "3.32" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00814" "64172" "ENSG00000128694" "OSGEPL1" "hsa:64172; Q96EV9; Q96NH5; Q9H4B0" "" "" "0" "0" "7.7" "9.0" "8.4" "24.7" "13.7" "7.1" "16.1" "14.5" "26.1" "92.1" "165.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60831" "PRA1 family protein 2 OS=Homo sapiens OX=9606 GN=PRAF2 PE=1 SV=1" "6" "1" "2" "1" "178" "19.2" "9.19" "390.80" "3.32" "1" "1" "transport" "other membranes;other cytoplasmic organelle" "" "Pf03208" "11230" "ENSG00000243279" "PRAF2" "B2RD20; hsa:11230; O60831" "" "" "0" "0" "43.2" "52.0" "56.2" "236.7" "99.4" "41.9" "53.7" "63.6" "52.3" "105.1" "119.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "1" "1" "2" "1" "963" "109.6" "6.51" "235.75" "3.32" "1" "1" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Insulin processing; Nuclear events stimulated by ALK signaling in cancer; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "12" "0" "35.4" "33.1" "43.6" "222.1" "82.3" "38.9" "57.8" "39.5" "49.5" "111.1" "105.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "9" "1" "1" "1" "239" "27.4" "5.73" "" "3.31" "" "1" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; UCH proteinases; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; The role of GTSE1 in G2/M progression after G2 checkpoint; KEAP1-NFE2L2 pathway; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; Regulation of PTEN stability and activity; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity" "Proteasome degradation" "61" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "5" "1" "2" "1" "227" "26.1" "8.28" "374.66" "3.31" "1" "1" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "Cristae formation; Mitochondrial protein import" "" "2" "0" "20.4" "20.4" "30.6" "92.1" "38.8" "22.1" "26.7" "23.0" "22.6" "42.7" "42.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRZ9" "Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1" "3" "2" "3" "2" "838" "97.0" "7.93" "918.90" "3.31" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "3070" "ENSG00000119969" "HELLS" "B2RB41; hsa:3070; Q3LID1; Q6I7N7; Q76H76; Q76H77; Q76H78; Q76H79; Q76H80; Q76H81; Q7Z397; Q7Z5X2; Q8N6P4; Q9H4P5; Q9NRZ9" "" "Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer" "2" "0" "111.6" "112.1" "129.7" "307.6" "168.7" "118.7" "217.1" "130.4" "158.8" "433.8" "459.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NHQ9" "ATP-dependent RNA helicase DDX55 OS=Homo sapiens OX=9606 GN=DDX55 PE=1 SV=3" "4" "2" "3" "2" "600" "68.5" "9.25" "777.88" "3.30" "2" "1" "" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf13959" "57696" "ENSG00000111364" "DDX55" "hsa:57696; Q658L6; Q8IYH0; Q8NHQ9; Q9HCH7" "" "" "0" "0" "22.5" "20.5" "21.9" "65.3" "42.2" "21.2" "52.5" "22.5" "23.5" "70.6" "53.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N183" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1" "5" "1" "2" "1" "169" "19.8" "8.97" "263.36" "3.30" "1" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf05071" "91942" "ENSG00000164182" "NDUFAF2" "A8K5I1; hsa:91942; Q8N183" "Complex I biogenesis" "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "2" "0" "212.0" "154.5" "230.1" "584.9" "332.3" "180.9" "275.4" "155.3" "216.0" "331.4" "150.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5HYJ3" "Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3" "3" "1" "1" "1" "339" "38.7" "9.25" "" "3.30" "" "1" "" "nucleus" "" "Pf16046" "143684" "ENSG00000077458" "FAM76B" "B2R9C2; hsa:143684; Q5HYJ3; Q6PIU3; Q8TC53" "" "" "0" "0" "9.0" "10.2" "11.0" "36.4" "17.3" "7.7" "20.7" "20.1" "44.6" "283.9" "300.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6IBW4" "Condensin-2 complex subunit H2 OS=Homo sapiens OX=9606 GN=NCAPH2 PE=1 SV=1" "5" "2" "3" "2" "605" "68.2" "4.74" "794.72" "3.30" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06278, Pf16858, Pf16869" "29781" "ENSG00000025770" "NCAPH2" "B7WPH1; hsa:29781; O43788; Q13391; Q6IBW4; Q96C14; Q96GJ0; Q9BQ71; Q9BUT3; Q9BVD1" "Condensation of Prophase Chromosomes" "IL-18 signaling pathway" "2" "0" "26.3" "26.6" "25.2" "60.5" "29.8" "31.2" "44.3" "21.8" "36.4" "169.2" "179.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "3" "1" "2" "1" "386" "42.9" "5.30" "294.30" "3.30" "1" "1" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Branched-chain amino acid catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism" "3" "0" "29.3" "28.2" "39.7" "212.4" "76.8" "24.8" "35.6" "28.5" "29.7" "72.1" "59.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "5" "2" "3" "2" "717" "82.9" "8.12" "971.18" "3.29" "2" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "19.4" "23.1" "29.9" "117.8" "43.4" "27.9" "52.0" "31.0" "35.0" "144.8" "124.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z392" "Trafficking protein particle complex subunit 11 OS=Homo sapiens OX=9606 GN=TRAPPC11 PE=1 SV=2" "2" "2" "3" "2" "1133" "128.8" "7.14" "840.73" "3.29" "2" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "" "Pf11817, Pf12742" "60684" "ENSG00000168538" "TRAPPC11" "A4QPB8; B2RCD6; hsa:60684; Q5U5I7; Q6FI73; Q7Z392; Q86T25; Q9H0L1; Q9H5K9; Q9H8Q1; Q9H9I7" "RAB GEFs exchange GTP for GDP on RABs" "Genes related to primary cilium development (based on CRISPR)" "2" "0" "15.8" "17.1" "17.8" "49.8" "29.3" "18.9" "30.5" "24.7" "36.8" "217.5" "240.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "8" "2" "3" "2" "183" "20.3" "4.72" "600.28" "3.29" "2" "1" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "466.4" "362.0" "532.6" "2031.3" "827.6" "348.9" "1091.4" "514.5" "422.9" "1052.8" "498.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L8A9" "Tubulinyl-Tyr carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=VASH1 PE=1 SV=1" "3" "1" "2" "1" "365" "40.9" "9.48" "380.90" "3.29" "1" "1" "cell cycle OR cell proliferation;protein metabolism;stress response;developmental processes;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf14822" "22846" "ENSG00000071246" "VASH1" "hsa:22846; Q7L8A9; Q96H02; Q9UBF4; Q9Y629" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "55.6" "61.1" "70.6" "151.6" "88.0" "61.5" "128.5" "66.5" "129.6" "364.7" "296.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "2" "1" "2" "1" "624" "70.8" "6.86" "251.61" "3.29" "1" "1" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "Sulfation biotransformation reaction" "4" "0" "32.4" "26.8" "40.7" "159.4" "64.6" "31.8" "59.6" "46.6" "52.5" "124.8" "109.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "5" "1" "1" "1" "392" "42.9" "5.97" "" "3.28" "" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "0" "33.1" "27.9" "38.4" "86.5" "49.2" "33.3" "56.2" "35.1" "48.1" "142.2" "107.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "2" "1" "2" "1" "1124" "124.1" "8.07" "433.00" "3.28" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "Retinoblastoma gene in cancer; Nephrotic syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "7" "2" "2" "2" "404" "45.5" "5.07" "251.26" "3.28" "1" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "20" "0" "70.2" "79.4" "135.3" "669.6" "203.9" "31.6" "145.9" "106.5" "112.0" "331.5" "277.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N392" "Rho GTPase-activating protein 18 OS=Homo sapiens OX=9606 GN=ARHGAP18 PE=1 SV=3" "2" "1" "2" "1" "663" "74.9" "6.44" "338.60" "3.28" "1" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "93663" "ENSG00000146376" "ARHGAP18" "E1P575; hsa:93663; Q58EZ3; Q6P679; Q6PJD7; Q8N392; Q96S64" "RHOC GTPase cycle; RHOA GTPase cycle" "" "2" "0" "16.7" "18.3" "26.7" "88.6" "45.1" "18.4" "29.9" "23.1" "33.3" "191.0" "213.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T0F9" "Coiled-coil and C2 domain-containing protein 1B OS=Homo sapiens OX=9606 GN=CC2D1B PE=1 SV=1" "1" "1" "2" "1" "858" "94.2" "5.26" "297.91" "3.28" "1" "1" "RNA metabolism OR transcription;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00168" "200014" "ENSG00000154222" "CC2D1B" "hsa:200014; Q49AE8; Q5T0F8; Q5T0F9; Q5T0G0; Q6ZNQ1; Q96AP3; Q96I04; Q96JJ1" "Sealing of the nuclear envelope (NE) by ESCRT-III" "" "1" "0" "16.1" "16.7" "20.7" "62.1" "31.5" "18.3" "33.5" "10.0" "14.7" "42.6" "32.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "8" "1" "2" "1" "153" "16.9" "6.60" "438.62" "3.28" "1" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "2" "0" "49.8" "41.7" "48.0" "89.7" "64.7" "44.4" "72.9" "53.8" "93.2" "323.0" "500.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T750" "Skin-specific protein 32 OS=Homo sapiens OX=9606 GN=XP32 PE=1 SV=1" "4" "1" "2" "1" "250" "26.2" "7.97" "271.76" "3.27" "1" "1" "other biological processes" "" "" "" "100129271" "ENSG00000198854" "KPLCE" "hsa:100129271; O14634; Q5T750" "" "" "0" "0" "371.4" "217.7" "79.9" "114.8" "90.3" "64.5" "112.8" "64.3" "114.6" "239.8" "190.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "10" "1" "2" "1" "133" "15.5" "6.06" "376.01" "3.26" "1" "1" "other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "40.0" "30.0" "56.2" "170.4" "62.4" "45.0" "106.4" "41.9" "52.8" "285.6" "280.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "6" "1" "2" "1" "216" "23.5" "8.41" "322.13" "3.25" "1" "1" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Clathrin-mediated endocytosis; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Associated Vesicle Biogenesis; TBC/RABGAPs" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "8" "0" "21.2" "23.4" "38.0" "136.8" "57.3" "32.9" "47.6" "42.4" "45.7" "132.2" "124.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "3" "1" "2" "1" "307" "34.5" "6.70" "314.00" "3.25" "1" "1" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "22q11.2 copy number variation syndrome" "5" "0" "23.5" "39.9" "46.2" "125.0" "75.1" "39.2" "94.8" "60.0" "63.2" "118.9" "78.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=EEF1AKNMT PE=1 SV=1" "2" "1" "2" "1" "699" "78.7" "6.73" "405.35" "3.25" "1" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf08241" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "1" "1" "2" "1" "942" "103.9" "6.37" "286.61" "3.23" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "10" "0" "21.6" "13.7" "24.7" "89.8" "42.7" "16.2" "33.1" "20.9" "28.0" "86.2" "106.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "4" "1" "1" "1" "521" "57.9" "4.96" "" "3.23" "" "1" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "Leptin signaling pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BUK0" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Homo sapiens OX=9606 GN=CHCHD7 PE=1 SV=1" "12" "1" "2" "1" "85" "10.1" "8.82" "335.08" "3.23" "1" "1" "cell organization and biogenesis" "mitochondrion" "" "" "79145" "ENSG00000170791" "CHCHD7" "A8K223; E9PBH3; hsa:79145; J3KNE9; Q7Z588; Q9BUK0" "Mitochondrial protein import" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42696" "RNA-binding protein 34 OS=Homo sapiens OX=9606 GN=RBM34 PE=1 SV=2" "3" "1" "2" "1" "430" "48.5" "10.11" "440.36" "3.22" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "23029" "ENSG00000188739" "RBM34" "A8K8J7; hsa:23029; P42696; Q8N2Z8; Q9H5A1" "" "" "0" "0" "18.4" "25.5" "18.4" "43.6" "25.6" "16.5" "32.8" "16.2" "17.7" "51.2" "28.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96AX1" "Vacuolar protein sorting-associated protein 33A OS=Homo sapiens OX=9606 GN=VPS33A PE=1 SV=1" "3" "1" "2" "1" "596" "67.6" "6.96" "329.72" "3.22" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00995" "65082" "ENSG00000139719" "VPS33A" "hsa:65082; Q547V4; Q96AX1; Q9H5Q0" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Network map of SARS-CoV-2 signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94874" "E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2" "1" "1" "2" "1" "794" "89.5" "6.79" "276.96" "3.22" "1" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09743" "23376" "ENSG00000014123" "UFL1" "A0PJ53; B4DJ57; C0H5X5; hsa:23376; O94874; Q8N765; Q9NTQ0" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "7.3" "13.0" "16.0" "57.3" "23.4" "9.0" "18.5" "19.9" "12.6" "70.6" "100.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "3" "1" "2" "1" "518" "58.4" "9.11" "340.27" "3.21" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "6" "1" "2" "1" "174" "19.8" "8.54" "351.20" "3.20" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "29.7" "25.1" "49.7" "211.7" "73.0" "29.1" "60.2" "41.7" "44.2" "158.0" "233.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "8" "2" "3" "2" "218" "24.5" "5.94" "609.57" "3.20" "2" "1" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "RAB geranylgeranylation; TBC/RABGAPs" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy" "4" "0" "248.0" "231.1" "323.9" "1017.0" "441.8" "205.9" "342.3" "228.8" "299.3" "578.6" "544.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "13" "1" "2" "1" "80" "9.1" "9.58" "396.29" "3.20" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "118.3" "116.2" "152.5" "546.5" "233.0" "97.8" "174.5" "117.4" "120.7" "296.7" "183.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14406" "Cytochrome c oxidase subunit 7A2, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2 PE=1 SV=1" "16" "1" "2" "1" "83" "9.4" "9.76" "294.14" "3.20" "1" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02238" "1347" "ENSG00000112695" "COX7A2" "B2R5E1; hsa:1347; P14406; Q3MIH5; Q5TF59; Q6FGI2" "" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly" "3" "0" "47.2" "51.6" "49.5" "140.5" "63.7" "47.2" "64.1" "45.9" "61.2" "117.4" "81.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRG9" "Aladin OS=Homo sapiens OX=9606 GN=AAAS PE=1 SV=1" "2" "1" "2" "1" "546" "59.5" "7.50" "321.55" "3.19" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "" "Pf00400" "8086" "ENSG00000094914" "AAAS" "hsa:8086; Q5JB47; Q9NRG9; Q9NWI6; Q9UG19" "RHOA GTPase cycle; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "29" "0" "49.2" "50.1" "57.0" "160.6" "81.7" "49.5" "66.4" "50.2" "55.5" "120.9" "107.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46926" "Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens OX=9606 GN=GNPDA1 PE=1 SV=1" "3" "1" "2" "1" "289" "32.6" "6.92" "271.40" "3.19" "1" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01182" "10007" "ENSG00000113552" "GNPDA1" "B7Z3X4; D3DQE7; hsa:10007; P46926" "Glycolysis" "11p11.2 copy number variation syndrome" "2" "0" "53.3" "72.5" "82.0" "405.1" "164.3" "77.4" "87.0" "72.4" "80.7" "197.7" "190.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZE1" "39S ribosomal protein L37, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "4" "1" "2" "1" "423" "48.1" "8.59" "329.12" "3.19" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "34.5" "36.9" "59.9" "157.4" "62.9" "48.0" "75.7" "50.5" "51.6" "169.5" "140.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51178" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Homo sapiens OX=9606 GN=PLCD1 PE=1 SV=2" "2" "1" "1" "1" "756" "85.6" "6.70" "" "3.19" "" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279" "5333" "ENSG00000187091" "PLCD1" "B3KR14; hsa:5333; P51178; Q86VN8" "Synthesis of IP3 and IP4 in the cytosol" "Myometrial relaxation and contraction pathways; GPR40 pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Orexin receptor pathway" "6" "0" "28.4" "28.4" "41.3" "140.2" "62.4" "30.6" "70.3" "39.5" "50.3" "142.8" "135.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "1" "1" "2" "1" "816" "91.3" "6.25" "341.98" "3.19" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "Synthesis of PIPs at the Golgi membrane" "" "1" "0" "4.3" "5.4" "7.5" "29.9" "13.6" "8.7" "10.3" "8.3" "7.7" "24.7" "31.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "2" "1" "2" "1" "450" "50.7" "7.06" "305.97" "3.19" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "hsa:1445; P41240; Q2M3N2; Q6FGZ6" "Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Signaling by BRAF and RAF1 fusions; Negative regulation of FLT3; GAB1 signalosome; Integrin signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; RHOH GTPase cycle; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "18" "0" "14.3" "13.7" "23.1" "79.9" "34.9" "6.9" "18.1" "12.7" "15.8" "34.4" "18.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z7H5" "Transmembrane emp24 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TMED4 PE=1 SV=1" "4" "1" "2" "1" "227" "25.9" "8.28" "314.69" "3.18" "1" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01105" "222068" "ENSG00000158604" "TMED4" "A4D2K8; B4DFJ4; hsa:222068; Q56VW3; Q7Z432; Q7Z7H5; Q8N2P6" "" "" "0" "0" "34.0" "26.8" "54.2" "423.5" "95.7" "33.7" "55.6" "47.1" "45.7" "193.9" "229.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BSG0" "Protease-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRADC1 PE=1 SV=1" "6" "1" "2" "1" "188" "21.0" "5.47" "421.09" "3.18" "1" "1" "" "non-structural extracellular" "" "Pf02225" "84279" "ENSG00000135617" "PRADC1" "hsa:84279; Q2Z1P2; Q9BSG0" "" "" "0" "0" "23.7" "14.2" "22.5" "34.4" "25.4" "23.2" "35.1" "15.1" "17.2" "40.3" "24.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "2" "1" "2" "1" "650" "72.5" "5.74" "338.29" "3.17" "1" "1" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "9.0" "4.8" "12.3" "132.6" "33.8" "1.7" "17.3" "15.3" "9.3" "24.2" "23.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "6" "1" "2" "1" "173" "18.9" "4.88" "241.96" "3.17" "1" "1" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905" "GCSH" "hsa:2653; P23434; Q9H1E9" "Glycine degradation" "" "2" "0" "24.1" "27.8" "41.9" "198.9" "62.9" "22.7" "37.7" "38.3" "39.0" "100.6" "76.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "6" "1" "2" "1" "193" "21.7" "5.39" "327.59" "3.17" "1" "1" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "23.5" "21.4" "35.1" "71.2" "59.6" "41.9" "69.6" "35.1" "39.8" "170.1" "181.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75419" "Cell division control protein 45 homolog OS=Homo sapiens OX=9606 GN=CDC45 PE=1 SV=1" "5" "2" "3" "2" "566" "65.5" "5.53" "588.86" "3.17" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02724" "8318" "ENSG00000093009" "CDC45" "B4DDB4; B4DDU3; E9PDH7; hsa:8318; O60856; O75419; Q20WK8; Q6UW54; Q9UP68" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription" "Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "1" "1" "2" "1" "1231" "141.2" "5.43" "350.31" "3.17" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "1" "1" "2" "1" "1081" "118.6" "4.96" "331.19" "3.16" "1" "1" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "5.7" "5.8" "6.6" "21.6" "7.6" "4.8" "13.7" "6.7" "7.4" "27.6" "39.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "2" "1" "2" "1" "722" "79.2" "6.80" "374.91" "3.16" "1" "1" "cell adhesion;other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NB46" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3" "3" "2" "3" "1" "1076" "115.0" "6.48" "781.36" "3.15" "2" "1" "" "" "" "Pf00023, Pf12796" "283373" "ENSG00000139645" "ANKRD52" "A6NE79; B1Q2K2; hsa:283373; Q8NB46" "" "" "0" "0" "5.5" "4.0" "5.9" "18.2" "8.6" "8.1" "13.1" "7.2" "5.4" "21.1" "19.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P1M0" "Long-chain fatty acid transport protein 4 OS=Homo sapiens OX=9606 GN=SLC27A4 PE=1 SV=1" "3" "2" "3" "2" "643" "72.0" "8.47" "570.88" "3.15" "2" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00501, Pf13193" "10999" "ENSG00000167114" "SLC27A4" "A8K2F7; hsa:10999; O95186; Q6P1M0; Q96G53" "Transport of fatty acids; Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)" "PPAR signaling pathway; Fatty acid transporters; Cholesterol metabolism; Fatty Acids and Lipoproteins Transport in Hepatocytes; Enterocyte cholesterol metabolism" "7" "0" "35.3" "39.6" "47.9" "146.0" "67.4" "35.2" "68.6" "48.9" "46.6" "175.1" "177.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96FK6" "WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=2 SV=1" "3" "1" "2" "1" "387" "43.2" "6.13" "395.37" "3.15" "1" "1" "developmental processes" "" "" "Pf00400" "112840" "ENSG00000140006" "WDR89" "hsa:112840; Q96FK6" "" "" "0" "0" "4.7" "7.8" "7.6" "34.8" "16.4" "5.6" "17.5" "10.8" "13.1" "24.0" "8.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NV66" "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 OS=Homo sapiens OX=9606 GN=TYW1 PE=2 SV=2" "2" "1" "2" "1" "732" "83.6" "6.87" "259.81" "3.15" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00258, Pf04055, Pf08608" "55253" "ENSG00000198874" "TYW1" "hsa:55253; Q6PJG8; Q75MG8; Q75MN3; Q86V12; Q8IVS7; Q9H9C4; Q9NV66" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "4.9" "7.9" "9.0" "43.7" "20.3" "6.9" "14.1" "12.1" "12.5" "52.4" "54.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "7" "1" "1" "1" "349" "39.0" "6.52" "" "3.15" "" "1" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UET6" "Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "3" "1" "2" "1" "329" "36.1" "5.69" "286.23" "3.14" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "39.3" "46.7" "53.0" "95.7" "64.6" "58.5" "76.5" "50.5" "57.4" "172.6" "153.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "4" "1" "2" "1" "215" "24.9" "5.55" "370.26" "3.14" "1" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Condensation of Prometaphase Chromosomes; Neutrophil degranulation; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Synthesis of PC" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "19" "0" "38.0" "36.6" "63.5" "448.7" "100.6" "28.6" "120.4" "54.1" "76.7" "796.6" "776.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "3" "1" "2" "1" "372" "42.0" "5.31" "330.59" "3.14" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex" "17q12 copy number variation syndrome" "6" "0" "57.5" "27.7" "25.1" "51.5" "28.7" "24.7" "33.2" "25.6" "21.3" "52.2" "42.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7RTN6" "STE20-related kinase adapter protein alpha OS=Homo sapiens OX=9606 GN=STRADA PE=1 SV=1" "3" "1" "2" "1" "431" "48.3" "6.48" "429.60" "3.14" "1" "1" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00069" "92335" "ENSG00000266173" "STRADA" "B4DDE3; B4DW17; hsa:92335; J3KTC9; Q5JPI2; Q7RTN6; Q7Z4K9; Q8NC31; Q8NCF1; Q9H272" "Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "3" "0" "27.1" "22.6" "34.6" "85.8" "50.1" "33.2" "56.0" "37.9" "80.3" "422.2" "390.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q93062" "RNA-binding protein with multiple splicing OS=Homo sapiens OX=9606 GN=RBPMS PE=1 SV=1" "11" "1" "1" "1" "196" "21.8" "8.07" "" "3.14" "" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "11030" "ENSG00000157110" "RBPMS" "D3DSU9; hsa:11030; Q92516; Q92517; Q92518; Q93062; Q96J26" "" "Exercise-induced circadian regulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "1" "1" "2" "1" "902" "102.5" "6.84" "359.80" "3.13" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "15q11.2 copy number variation syndrome" "3" "0" "20.9" "16.5" "20.8" "66.3" "34.3" "16.7" "40.6" "17.3" "21.5" "81.4" "62.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10155" "60 kDa SS-A/Ro ribonucleoprotein OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "2" "1" "2" "1" "538" "60.6" "8.03" "286.14" "3.13" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "11.3" "14.8" "19.9" "64.4" "23.1" "13.3" "17.8" "15.5" "15.5" "40.3" "45.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NXE8" "Pre-mRNA-splicing factor CWC25 homolog OS=Homo sapiens OX=9606 GN=CWC25 PE=1 SV=1" "2" "1" "2" "1" "425" "49.6" "10.18" "303.40" "3.13" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10197, Pf12542" "54883" "ENSG00000273559; ENSG00000276761" "CWC25" "A0JLM3; hsa:54883; Q68DK5; Q9NXE8" "mRNA Splicing - Major Pathway" "17q12 copy number variation syndrome" "2" "0" "23.2" "12.2" "14.5" "34.6" "23.9" "12.2" "28.9" "20.9" "30.6" "89.3" "72.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "9" "1" "2" "1" "118" "12.7" "7.30" "280.03" "3.13" "1" "1" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "4.5" "11.3" "15.4" "126.8" "27.5" "0.0" "5.0" "6.4" "6.0" "6.4" "7.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYK5" "39S ribosomal protein L39, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "3" "1" "2" "1" "338" "38.7" "7.65" "297.14" "3.12" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "2.4" "3.7" "6.8" "52.4" "11.1" "0.8" "11.7" "7.3" "6.0" "36.8" "44.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "3" "1" "1" "1" "434" "46.7" "4.42" "" "3.12" "" "1" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "NOD1/2 Signaling Pathway; Thromboxane signalling through TP receptor; Signaling by EGFR; Signaling by VEGF" "Nucleotide-binding oligomerization domain (NOD) pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5HYI8" "Rab-like protein 3 OS=Homo sapiens OX=9606 GN=RABL3 PE=1 SV=1" "5" "1" "2" "1" "236" "26.4" "7.11" "354.86" "3.12" "1" "1" "transport;other biological processes" "other cell component" "other molecular function" "Pf08477" "285282" "ENSG00000144840" "RABL3" "hsa:285282; Q5HYI8; Q8WUD3" "" "" "0" "0" "20.3" "25.1" "36.6" "83.3" "31.6" "20.2" "62.6" "31.3" "35.0" "106.7" "51.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "1" "1" "1" "1" "2357" "251.7" "5.80" "" "3.12" "" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "COPII-mediated vesicle transport" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "3" "1" "2" "1" "494" "53.8" "5.87" "461.46" "3.12" "1" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "Carnitine synthesis" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "4" "0" "44.6" "33.0" "55.9" "148.6" "67.0" "32.3" "54.3" "25.3" "37.5" "42.2" "25.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2" "5" "2" "3" "2" "452" "49.5" "7.61" "857.03" "3.11" "2" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "206.1" "206.5" "335.6" "1588.9" "594.8" "177.4" "289.8" "254.8" "225.0" "485.1" "436.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P1F3" "Costars family protein ABRACL OS=Homo sapiens OX=9606 GN=ABRACL PE=1 SV=1" "16" "1" "2" "1" "81" "9.1" "6.29" "450.85" "3.11" "1" "1" "other biological processes" "" "" "Pf14705" "58527" "ENSG00000146386" "ABRACL" "hsa:58527; Q5SZC8; Q9P0A1; Q9P1F3" "" "" "0" "0" "2.0" "1.8" "9.9" "102.8" "19.6" "0.5" "6.8" "8.1" "6.5" "18.2" "17.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "1" "1" "2" "1" "1354" "158.1" "5.90" "238.55" "3.10" "1" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "RHOA GTPase cycle; G alpha (12/13) signalling events; EPHB-mediated forward signaling; Neutrophil degranulation; Apoptotic cleavage of cellular proteins; Potential therapeutics for SARS; RHOC GTPase cycle; RHOB GTPase cycle; VEGFA-VEGFR2 Pathway; RND3 GTPase cycle; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "34" "0" "11.5" "7.2" "15.7" "84.8" "34.4" "4.9" "17.0" "7.6" "14.0" "24.5" "20.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "2" "1" "2" "1" "603" "68.2" "8.91" "313.60" "3.10" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Phosphorylation of Emi1; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Mitotic Telophase/Cytokinesis; Mitotic Metaphase/Anaphase Transition" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "30" "0" "30.6" "26.9" "33.2" "86.2" "49.0" "27.1" "55.0" "22.5" "29.3" "84.3" "68.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6ZU35" "Capping protein inhibiting regulator of actin dynamics OS=Homo sapiens OX=9606 GN=CRACD PE=1 SV=3" "1" "1" "2" "1" "1233" "136.7" "5.60" "355.22" "3.09" "1" "1" "cell organization and biogenesis;other biological processes" "cytosol" "" "Pf15262" "57482" "ENSG00000109265" "CRACD" "hsa:57482; Q6ZU35; Q9NTE2; Q9NTP8; Q9ULK9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2M389" "WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2" "1" "1" "2" "1" "1173" "136.3" "7.44" "286.94" "3.09" "1" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14744, Pf14745, Pf14746" "23325" "ENSG00000136051" "WASHC4" "hsa:23325; Q2M389; Q2NL83; Q8IW61; Q8N5W7; Q9NVD6; Q9UPW7" "" "" "0" "0" "62.7" "57.7" "77.0" "197.5" "98.5" "68.0" "123.2" "85.1" "89.4" "236.2" "209.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "11" "2" "3" "2" "152" "17.0" "8.31" "810.43" "3.09" "2" "1" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "66.8" "62.6" "79.2" "147.5" "98.4" "73.0" "129.0" "72.3" "114.1" "338.7" "338.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BXC9" "Bardet-Biedl syndrome 2 protein OS=Homo sapiens OX=9606 GN=BBS2 PE=1 SV=1" "1" "1" "2" "1" "721" "79.8" "6.15" "392.66" "3.09" "1" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "59.6" "56.1" "49.1" "106.8" "60.3" "41.6" "84.2" "85.5" "183.4" "932.6" "812.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "7" "2" "3" "2" "248" "27.1" "4.51" "623.04" "3.08" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "17" "0" "285.8" "267.1" "322.8" "1049.3" "454.6" "199.4" "434.4" "249.6" "279.8" "557.9" "341.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N3C0" "Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3" "1" "1" "2" "1" "2202" "251.3" "7.09" "341.88" "3.08" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf02889" "10973" "ENSG00000112249" "ASCC3" "E7EW23; hsa:10973; O43738; Q4G1A0; Q5VTN2; Q8N3C0; Q9H1I9; Q9H5A2; Q9NTR0" "ALKBH3 mediated reversal of alkylation damage" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P1Q0" "Vacuolar protein sorting-associated protein 54 OS=Homo sapiens OX=9606 GN=VPS54 PE=1 SV=2" "2" "1" "2" "1" "977" "110.5" "6.55" "277.57" "3.08" "1" "1" "cell-cell signaling;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf07928, Pf10475" "51542" "ENSG00000143952" "VPS54" "hsa:51542; Q5VIR5; Q86YF7; Q8N6G3; Q9NPV0; Q9NT07; Q9NUJ0; Q9P1Q0" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "4.3" "4.7" "5.2" "13.9" "7.2" "6.8" "10.5" "5.4" "4.8" "35.8" "26.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14192" "Four and a half LIM domains protein 2 OS=Homo sapiens OX=9606 GN=FHL2 PE=1 SV=3" "8" "2" "2" "2" "279" "32.2" "7.55" "381.98" "3.07" "1" "1" "RNA metabolism OR transcription;developmental processes;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf00412" "2274" "ENSG00000115641" "FHL2" "hsa:2274; Q13229; Q13644; Q14192; Q2I5I4; Q5TM15; Q9P294" "PPARA activates gene expression" "Androgen receptor signaling pathway; RANKL/RANK signaling pathway; Ectoderm differentiation; VEGFA-VEGFR2 signaling; 11p11.2 copy number variation syndrome" "6" "0" "107.6" "109.6" "137.5" "345.1" "156.1" "110.3" "225.6" "127.0" "141.8" "411.2" "249.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "6" "1" "2" "1" "195" "22.0" "5.44" "292.40" "3.07" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "29" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35219" "Carbonic anhydrase-related protein OS=Homo sapiens OX=9606 GN=CA8 PE=1 SV=3" "7" "1" "2" "1" "290" "33.0" "4.86" "369.69" "3.07" "1" "1" "signal transduction" "other cell component" "other molecular function" "Pf00194" "767" "ENSG00000178538" "CA8" "A8K0A5; B3KQZ7; hsa:767; P35219; Q32MY2" "" "PKC-gamma calcium signaling pathway in ataxia" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQ15" "SOSS complex subunit B1 OS=Homo sapiens OX=9606 GN=NABP2 PE=1 SV=1" "6" "1" "2" "1" "211" "22.3" "9.06" "384.39" "3.06" "1" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336" "79035" "ENSG00000139579" "NABP2" "A6NDF8; hsa:79035; Q6XYC8; Q9BQ15" "RNA polymerase II transcribes snRNA genes" "Mesodermal commitment pathway" "2" "0" "25.6" "20.5" "37.9" "67.9" "38.4" "21.7" "43.2" "19.3" "25.8" "57.5" "40.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "3" "2" "3" "2" "557" "65.6" "6.64" "723.36" "3.06" "2" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "mRNA Splicing - Major Pathway" "" "1" "0" "252.1" "198.2" "206.3" "472.2" "269.2" "188.6" "319.6" "225.1" "261.0" "789.8" "719.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "4" "2" "4" "2" "483" "54.4" "8.66" "1101.75" "3.05" "2" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "257.1" "197.1" "250.3" "477.3" "297.5" "234.2" "389.1" "152.8" "214.3" "548.6" "351.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "1" "1" "2" "1" "941" "107.8" "7.05" "307.05" "3.05" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "SARS-CoV-2 modulates autophagy" "Network map of SARS-CoV-2 signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q00325" "Phosphate carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2" "6" "2" "3" "2" "362" "40.1" "9.38" "490.65" "3.05" "2" "1" "transport" "plasma membrane;other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00153" "5250" "ENSG00000075415" "SLC25A3" "B3KS34; hsa:5250; Q00325; Q7Z7N7; Q96A03" "" "" "0" "0" "107.7" "120.6" "155.5" "545.1" "206.9" "111.9" "223.8" "139.9" "151.7" "642.0" "749.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00291" "Huntingtin-interacting protein 1 OS=Homo sapiens OX=9606 GN=HIP1 PE=1 SV=5" "1" "1" "2" "1" "1037" "116.1" "5.30" "268.22" "3.04" "1" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "3092" "ENSG00000127946" "HIP1" "B4E3I7; E7ES17; hsa:3092; O00291; O00328; Q2TB58; Q8TDL4; V5LU97" "Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "DYRK1A involvement regarding cell proliferation in brain development" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4X0" "AMME syndrome candidate gene 1 protein OS=Homo sapiens OX=9606 GN=AMMECR1 PE=1 SV=1" "4" "1" "2" "1" "333" "35.4" "8.63" "393.39" "3.04" "1" "1" "" "mitochondrion;nucleus" "" "Pf01871" "9949" "ENSG00000101935" "AMMECR1" "hsa:9949; Q5JYV9; Q6P9D8; Q8WX22; Q9UIQ8; Q9Y4X0" "" "" "0" "0" "32.4" "25.5" "31.0" "41.8" "38.0" "36.6" "44.5" "22.0" "25.5" "60.4" "49.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "2" "1" "2" "1" "640" "70.7" "7.62" "438.13" "3.03" "1" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Gluconeogenesis" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "7" "0" "12.3" "12.4" "22.2" "227.4" "34.6" "3.7" "29.4" "16.1" "18.6" "62.6" "70.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75340" "Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1" "6" "1" "2" "1" "191" "21.9" "5.40" "256.76" "3.03" "1" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "10016" "ENSG00000249915" "PDCD6" "B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0" "" "Epithelial to mesenchymal transition in colorectal cancer" "1" "0" "49.7" "36.8" "62.2" "206.5" "101.8" "54.6" "93.9" "60.4" "66.6" "139.5" "94.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N1B4" "Vacuolar protein sorting-associated protein 52 homolog OS=Homo sapiens OX=9606 GN=VPS52 PE=1 SV=1" "2" "1" "2" "1" "723" "82.2" "5.99" "261.42" "3.02" "1" "1" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04129" "6293" "ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590; ENSG00000228425; ENSG00000236014" "VPS52" "A2BF38; B0UZZ4; B4DNI9; hsa:6293; Q53GR4; Q5JPA0; Q5SQW1; Q8IUN6; Q8N1B4; Q9NPT5" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "2.3" "3.1" "8.2" "14.6" "7.2" "6.7" "7.1" "4.3" "8.4" "30.0" "24.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "1" "1" "2" "1" "735" "79.3" "4.91" "269.17" "3.02" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "14.4" "8.2" "22.1" "49.3" "22.9" "11.6" "28.1" "15.7" "20.4" "132.2" "140.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00217" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS8 PE=1 SV=1" "4" "1" "2" "1" "210" "23.7" "6.34" "329.14" "3.01" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf12838" "4728" "ENSG00000110717" "NDUFS8" "B2RB86; hsa:4728; O00217; Q0VDA8" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "25.1" "32.1" "47.0" "251.9" "73.4" "34.4" "64.6" "43.7" "54.9" "172.1" "189.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "3" "1" "2" "1" "351" "38.7" "6.09" "394.25" "3.01" "1" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08662, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "93.9" "66.9" "110.7" "326.5" "152.1" "78.8" "145.1" "70.6" "99.3" "258.8" "190.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "6" "2" "3" "2" "453" "52.0" "6.39" "590.19" "3.01" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "MASTL Facilitates Mitotic Progression" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "3" "0" "6.0" "4.7" "6.8" "14.9" "9.7" "3.7" "7.1" "6.1" "6.0" "28.8" "19.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "2" "1" "2" "1" "603" "69.9" "8.18" "233.90" "3.01" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "31.9" "24.3" "30.2" "73.7" "36.1" "34.3" "51.1" "20.8" "44.2" "172.7" "133.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "3" "2" "3" "2" "744" "82.5" "6.95" "617.02" "3.01" "2" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; hsa:4905; P46459; Q8N6D7; Q9UKZ2" "COPII-mediated vesicle transport; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway" "8" "0" "40.3" "31.1" "49.2" "212.3" "87.6" "25.5" "43.0" "52.3" "40.7" "82.0" "87.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94851" "[F-actin]-monooxygenase MICAL2 OS=Homo sapiens OX=9606 GN=MICAL2 PE=1 SV=1" "2" "2" "3" "1" "1124" "126.6" "8.65" "553.12" "3.01" "2" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IX18" "Probable ATP-dependent RNA helicase DHX40 OS=Homo sapiens OX=9606 GN=DHX40 PE=1 SV=2" "2" "1" "2" "1" "779" "88.5" "8.65" "408.20" "3.01" "1" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717" "79665" "ENSG00000108406" "DHX40" "B3KTJ5; C9JR60; hsa:79665; Q5JPH4; Q8IX18; Q8TC86; Q8WY53; Q9BXM1; Q9H6M9" "" "" "0" "0" "47.8" "41.7" "54.8" "160.5" "72.4" "49.8" "63.9" "48.7" "51.6" "133.5" "144.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "2" "1" "2" "1" "492" "57.2" "5.92" "530.43" "3.01" "1" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "mRNA Splicing - Major Pathway" "" "1" "0" "49.5" "44.0" "73.5" "209.7" "96.1" "42.3" "89.8" "40.0" "57.0" "118.3" "96.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "8" "1" "2" "1" "159" "17.4" "9.67" "375.42" "3.01" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "mRNA Splicing - Major Pathway" "" "1" "0" "23.7" "23.1" "33.8" "108.5" "39.8" "31.7" "64.0" "31.7" "40.8" "111.8" "74.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "4" "1" "2" "1" "313" "34.0" "4.87" "311.96" "3.00" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "14.4" "13.3" "24.9" "160.2" "39.0" "2.1" "18.7" "15.9" "12.9" "40.4" "32.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UGI8" "Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1" "4" "1" "1" "1" "421" "48.0" "7.68" "" "3.00" "" "1" "other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412, Pf06297" "26136" "ENSG00000135269" "TES" "A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8" "" "" "0" "0" "20.9" "15.9" "18.8" "62.1" "34.4" "24.5" "56.9" "27.1" "57.2" "375.1" "321.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96KQ4" "Apoptosis-stimulating of p53 protein 1 OS=Homo sapiens OX=9606 GN=PPP1R13B PE=1 SV=3" "1" "1" "2" "1" "1090" "119.5" "6.76" "291.99" "3.00" "1" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00018, Pf00023" "23368" "ENSG00000088808" "PPP1R13B" "B2RMX5; hsa:23368; O94870; Q96KQ4" "TP53 Regulates Transcription of Death Receptors and Ligands; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors" "" "5" "0" "37.1" "32.4" "42.6" "78.6" "38.4" "37.8" "42.4" "36.8" "32.3" "55.5" "53.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "1" "1" "2" "1" "863" "96.5" "6.74" "442.94" "3.00" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication; 10q11.21q11.23 copy number variation syndrome" "13" "0" "79.8" "89.1" "109.7" "359.0" "167.0" "71.6" "101.2" "60.3" "78.1" "113.8" "81.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVA1" "Ubiquinol-cytochrome-c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3" "4" "1" "2" "1" "299" "34.6" "8.91" "331.16" "3.00" "1" "1" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "" "Pf03981" "55245" "ENSG00000101019" "UQCC1" "B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1" "" "Ciliary landscape; Mitochondrial complex III assembly" "2" "0" "0.0" "0.0" "2.9" "9.4" "0.0" "3.8" "2.3" "3.1" "8.8" "30.3" "69.3" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "1" "1" "2" "1" "620" "69.9" "5.59" "298.71" "3.00" "1" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "6" "0" "12.5" "10.6" "16.7" "51.5" "20.4" "10.2" "31.9" "18.8" "17.9" "43.3" "28.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "8" "1" "2" "1" "95" "10.8" "6.52" "340.48" "3.00" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "58.9" "70.9" "119.0" "469.9" "201.4" "69.1" "140.7" "108.1" "97.2" "235.3" "190.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00625" "Pirin OS=Homo sapiens OX=9606 GN=PIR PE=1 SV=1" "7" "2" "3" "2" "290" "32.1" "6.92" "631.48" "3.00" "2" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02678, Pf05726" "8544" "ENSG00000087842" "PIR" "hsa:8544; O00625; Q5U0G0; Q6FHD2" "Digestion" "" "1" "0" "30.4" "40.3" "65.7" "331.3" "105.6" "14.2" "38.1" "44.6" "29.6" "55.1" "49.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "2" "1" "2" "1" "562" "61.4" "6.76" "348.57" "3.00" "1" "1" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "13" "0" "20.1" "21.7" "43.3" "283.3" "71.4" "4.1" "23.8" "28.6" "30.6" "58.7" "54.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82930" "28S ribosomal protein S34, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "4" "1" "2" "1" "218" "25.6" "9.98" "336.17" "2.99" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "220.4" "244.8" "293.1" "1032.7" "426.4" "217.3" "458.8" "281.7" "296.6" "819.9" "657.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96JP5" "E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1" "2" "1" "2" "1" "570" "63.4" "7.36" "438.65" "2.99" "1" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00096" "80829" "ENSG00000186660" "ZFP91" "A6NHC4; A8MSG7; hsa:80829; Q86V47; Q96JP4; Q96JP5; Q96QA3" "" "" "0" "0" "18.8" "14.6" "19.1" "71.0" "31.1" "11.9" "30.8" "16.8" "15.6" "26.9" "37.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "4" "1" "2" "1" "304" "34.3" "9.28" "384.04" "2.99" "1" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "19.7" "11.9" "14.1" "18.5" "16.2" "21.2" "32.9" "11.1" "21.8" "35.8" "33.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H8H2" "Probable ATP-dependent RNA helicase DDX31 OS=Homo sapiens OX=9606 GN=DDX31 PE=1 SV=2" "2" "1" "2" "1" "851" "94.0" "9.99" "371.98" "2.98" "1" "1" "other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "64794" "ENSG00000125485" "DDX31" "hsa:64794; Q5K6N2; Q5K6N3; Q5K6N4; Q5VZJ4; Q5VZJ9; Q96E91; Q96NY2; Q96SX5; Q9H5K6; Q9H8H2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "n/a" "1" "" "False" "IsMasterProtein" "Q14498" "RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2" "2" "1" "2" "1" "530" "59.3" "10.10" "289.90" "2.98" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00076, Pf15519" "9584" "ENSG00000131051" "RBM39" "A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499" "mRNA Splicing - Major Pathway" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "12.2" "11.7" "21.0" "75.9" "39.8" "10.6" "30.6" "16.7" "22.6" "56.3" "35.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "3" "1" "3" "1" "396" "44.6" "5.03" "591.67" "2.98" "1" "1" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "10" "2" "3" "2" "204" "23.2" "5.11" "630.89" "2.98" "2" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "Ciliary landscape; Nephrotic syndrome" "11" "0" "10.4" "11.9" "49.6" "740.6" "153.9" "0.0" "23.8" "46.5" "37.1" "67.5" "99.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "4" "1" "2" "1" "385" "44.1" "6.23" "282.24" "2.97" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome" "7" "0" "55.9" "37.5" "66.4" "216.0" "96.1" "65.8" "132.7" "88.4" "158.0" "280.7" "234.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14671" "Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3" "1" "1" "2" "1" "1186" "126.4" "6.84" "527.91" "2.97" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "9698" "ENSG00000134644" "PUM1" "A8K6W4; B4DG92; D3DPN3; E9PCJ0; hsa:9698; Q14671; Q53HH5; Q5VXY7; Q9HAN1" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "n/a" "High" "n/a" "n/a" "High" "High" "High" "n/a" "High" "1" "" "False" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "3" "1" "2" "1" "507" "55.0" "7.72" "254.09" "2.97" "1" "1" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "7" "0" "35.9" "45.2" "44.1" "137.7" "84.5" "44.3" "57.5" "32.5" "46.9" "109.9" "101.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "1" "1" "2" "1" "1269" "144.7" "6.05" "265.62" "2.96" "1" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "" "VEGFA-VEGFR2 signaling" "1" "0" "22.7" "26.7" "25.8" "102.0" "47.0" "17.7" "24.1" "31.5" "21.0" "106.9" "137.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6NYC1" "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1" "3" "1" "2" "1" "403" "46.4" "8.69" "281.71" "2.96" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "23210" "ENSG00000070495" "JMJD6" "B3KMN8; B4DGX1; hsa:23210; Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2" "HDMs demethylate histones" "" "1" "0" "41.1" "30.8" "44.2" "149.4" "69.1" "47.9" "94.9" "132.7" "51.2" "121.6" "140.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75152" "Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3" "2" "1" "2" "1" "810" "89.1" "8.37" "233.75" "2.96" "1" "1" "other metabolic processes;transport" "nucleus" "other molecular function" "Pf15663" "9877" "ENSG00000058673" "ZC3H11A" "hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "23.7" "19.3" "25.3" "84.5" "44.5" "23.4" "64.0" "23.0" "25.2" "66.0" "29.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5V0" "Zinc finger protein 706 OS=Homo sapiens OX=9606 GN=ZNF706 PE=1 SV=1" "14" "1" "1" "1" "76" "8.5" "10.01" "" "2.95" "" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf04419, Pf12874" "51123" "ENSG00000120963" "ZNF706" "A8K362; hsa:51123; Q9Y5V0" "Generic Transcription Pathway" "" "1" "0" "146.5" "103.3" "118.7" "203.1" "156.3" "99.9" "176.7" "156.1" "216.8" "632.4" "696.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "2" "1" "2" "1" "510" "56.5" "7.18" "261.32" "2.95" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "8.5" "9.5" "10.1" "30.1" "16.2" "9.2" "17.6" "9.3" "11.1" "69.0" "62.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75530" "Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2" "2" "1" "2" "1" "441" "50.2" "7.03" "299.85" "2.95" "1" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "8726" "ENSG00000074266" "EED" "A8K7V5; hsa:8726; O00149; O75530; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7" "Transcriptional Regulation by E2F6; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H501" "ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1" "1" "1" "2" "1" "851" "98.7" "5.11" "403.93" "2.95" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08159" "51575" "ENSG00000089048" "ESF1" "hsa:51575; Q86X92; Q9H501; Q9H9Q5; Q9HA35; Q9NX93; Q9P1S6" "" "" "0" "0" "34.0" "31.8" "35.0" "73.4" "47.6" "26.4" "43.4" "34.0" "39.8" "64.9" "61.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "1" "2" "3" "2" "2620" "294.2" "6.14" "518.30" "2.95" "2" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf12030" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "Ub-specific processing proteases" "" "1" "0" "80.2" "48.5" "74.8" "238.7" "86.4" "36.5" "87.0" "40.3" "49.1" "276.9" "248.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q02952" "A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4" "1" "1" "2" "1" "1782" "191.4" "4.41" "364.69" "2.94" "1" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03832, Pf10522" "9590" "ENSG00000131016" "AKAP12" "hsa:9590; O00310; O00498; Q02952; Q4LE68; Q5SZ80; Q5TGN1; Q68D82; Q99970" "RHOD GTPase cycle; RHOF GTPase cycle" "G protein signaling pathways" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16514" "Transcription initiation factor TFIID subunit 12 OS=Homo sapiens OX=9606 GN=TAF12 PE=1 SV=1" "7" "1" "2" "1" "161" "17.9" "7.99" "267.18" "2.94" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03847" "6883" "ENSG00000120656" "TAF12" "D3DPM5; hsa:6883; Q15775; Q16514; Q5T077" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; HATs acetylate histones" "Eukaryotic transcription initiation" "11" "0" "9.3" "7.4" "11.5" "28.9" "14.3" "7.4" "18.2" "11.7" "9.2" "39.3" "28.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "1" "1" "2" "1" "1094" "118.2" "7.06" "264.16" "2.93" "1" "1" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "COPII-mediated vesicle transport; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "9.9" "10.8" "10.9" "39.9" "20.8" "8.7" "22.8" "19.8" "30.8" "62.2" "51.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "1" "1" "2" "1" "1593" "182.7" "8.44" "326.18" "2.92" "1" "1" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "137.0" "85.5" "116.3" "230.8" "153.7" "114.7" "185.1" "74.4" "111.2" "326.9" "264.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "3" "1" "2" "1" "302" "33.8" "5.49" "353.77" "2.92" "1" "1" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Metabolism of polyamines" "Methionine de novo and salvage pathway; Amino acid metabolism" "3" "0" "85.4" "89.4" "114.2" "484.7" "161.9" "42.2" "80.5" "91.8" "66.1" "124.2" "121.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "2" "1" "2" "1" "710" "80.3" "8.15" "300.13" "2.92" "1" "1" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "9.5" "8.8" "15.6" "48.2" "16.9" "6.7" "15.8" "13.9" "16.6" "26.1" "23.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "5" "3" "4" "3" "409" "43.1" "4.84" "829.15" "2.92" "3" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Formation of Incision Complex in GG-NER; Josephin domain DUBs; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "7" "0" "289.0" "253.3" "395.2" "1292.2" "468.7" "222.1" "472.8" "276.2" "358.3" "950.9" "622.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95299" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA10 PE=1 SV=1" "3" "1" "2" "1" "355" "40.7" "8.48" "245.17" "2.92" "1" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion;other cell component" "transporter activity" "Pf01712" "4705" "ENSG00000130414" "NDUFA10" "hsa:4705; O95299; Q8WXC9" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; 2q37 copy number variation syndrome; Oxidative phosphorylation" "6" "0" "35.2" "41.4" "57.4" "145.3" "64.7" "42.3" "97.6" "49.0" "49.4" "163.2" "129.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "23" "1" "2" "1" "87" "10.0" "6.57" "491.34" "2.91" "1" "1" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Mitochondrial Fatty Acid Beta-Oxidation" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "6" "0" "18.2" "17.3" "33.9" "441.0" "65.1" "16.5" "32.4" "32.3" "34.2" "85.8" "81.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13322" "Growth factor receptor-bound protein 10 OS=Homo sapiens OX=9606 GN=GRB10 PE=1 SV=2" "2" "1" "2" "1" "594" "67.2" "7.87" "273.10" "2.91" "1" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00169, Pf00788, Pf08947" "2887" "ENSG00000106070" "GRB10" "A4D258; A7VJ95; A8K0E6; D3DVM9; hsa:2887; O00427; O00701; O75222; Q13322; Q92606; Q92907; Q92948" "Response of EIF2AK1 (HRI) to heme deficiency; RET signaling; Signaling by SCF-KIT; FLT3 Signaling; IRS activation; Signal attenuation" "Kit receptor signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; EGF/EGFR signaling pathway; Insulin signaling" "13" "0" "22.4" "19.7" "24.3" "54.8" "41.4" "26.8" "38.2" "25.8" "22.3" "65.4" "101.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15139" "Serine/threonine-protein kinase D1 OS=Homo sapiens OX=9606 GN=PRKD1 PE=1 SV=2" "2" "1" "2" "1" "912" "101.6" "6.62" "291.41" "2.91" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "5587" "ENSG00000184304" "PRKD1" "A6NL64; B2RAF6; hsa:5587; Q15139" "Sphingolipid de novo biosynthesis" "Apoptosis modulation and signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Gastrin signaling pathway; Osteoblast differentiation and related diseases; Calcium regulation in cardiac cells" "10" "0" "10.3" "8.9" "11.7" "41.3" "17.4" "10.3" "14.4" "10.9" "16.9" "40.9" "46.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "3" "1" "2" "1" "249" "27.4" "8.06" "235.80" "2.91" "1" "1" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "163.2" "143.8" "186.2" "451.2" "254.2" "172.6" "249.9" "129.9" "150.4" "352.6" "324.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13418" "Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2" "2" "1" "2" "1" "452" "51.4" "8.07" "314.57" "2.90" "1" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "3611" "ENSG00000166333" "ILK" "B7Z1I0; B7Z418; D3DQU0; hsa:3611; P57043; Q13418; Q68DZ3" "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system; 2q37 copy number variation syndrome" "13" "0" "18.7" "12.1" "23.9" "52.1" "32.1" "14.4" "26.1" "15.9" "27.2" "87.0" "134.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "1" "1" "2" "1" "881" "96.7" "4.55" "252.19" "2.90" "1" "1" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "COPII-mediated vesicle transport" "" "1" "0" "12.0" "12.5" "16.9" "38.0" "23.1" "13.9" "18.2" "14.6" "18.1" "66.0" "58.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "10" "1" "2" "1" "99" "11.3" "9.31" "259.80" "2.89" "1" "1" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "25.4" "23.8" "34.4" "71.0" "40.1" "30.8" "35.7" "32.6" "48.2" "206.6" "453.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "4" "1" "2" "1" "361" "40.8" "5.25" "247.25" "2.89" "1" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q3ZCQ8" "Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2" "5" "2" "3" "2" "353" "39.6" "8.37" "556.87" "2.89" "2" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;mitochondrion;nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03031" "92609" "ENSG00000105197" "TIMM50" "hsa:92609; Q330K1; Q3ZCQ8; Q6QA00; Q96FJ5; Q96GY2; Q9H370" "Mitochondrial protein import" "" "1" "0" "243.3" "241.2" "311.4" "976.1" "440.3" "200.1" "417.9" "227.6" "269.4" "848.8" "811.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "2" "1" "2" "1" "535" "57.2" "8.28" "380.77" "2.88" "1" "1" "other metabolic processes;developmental processes" "mitochondrion" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Degradation of GABA" "Fragile X syndrome" "2" "0" "23.0" "15.1" "20.2" "74.0" "40.4" "12.4" "17.1" "26.5" "24.2" "45.3" "108.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O96008" "Mitochondrial import receptor subunit TOM40 homolog OS=Homo sapiens OX=9606 GN=TOMM40 PE=1 SV=1" "3" "1" "2" "1" "361" "37.9" "7.25" "277.50" "2.88" "1" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;mitochondrion;other cell component" "transporter activity" "Pf01459" "10452" "ENSG00000130204" "TOMM40" "A0A024R0P9; hsa:10452; O96008; Q86VW4; Q8WY09; Q8WY10; Q8WY11; Q9BR95" "Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "IL-18 signaling pathway" "3" "0" "6.8" "6.8" "8.1" "63.8" "16.1" "3.0" "9.6" "7.5" "8.6" "24.5" "35.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z417" "Nuclear fragile X mental retardation-interacting protein 2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "2" "1" "2" "1" "695" "76.1" "8.70" "379.66" "2.88" "1" "1" "" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "406.0" "237.2" "313.1" "388.9" "380.1" "316.1" "470.1" "162.9" "326.1" "472.9" "247.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H9C1" "Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1" "2" "1" "2" "1" "493" "57.0" "7.40" "333.02" "2.88" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04840" "63894" "ENSG00000151445" "VIPAS39" "B4DPI6; hsa:63894; O95434; Q9H7E1; Q9H9C1; Q9H9I9" "" "" "0" "0" "66.0" "50.5" "64.6" "108.8" "77.7" "65.3" "119.2" "50.2" "70.2" "195.9" "147.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75718" "Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1" "3" "1" "2" "1" "401" "46.5" "5.73" "264.96" "2.87" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "" "10491" "ENSG00000170275" "CRTAP" "B2RBL6; hsa:10491; O75718" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "7.2" "9.9" "9.5" "81.9" "23.0" "3.0" "16.0" "14.2" "12.1" "62.9" "55.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09669" "Cytochrome c oxidase subunit 6C OS=Homo sapiens OX=9606 GN=COX6C PE=1 SV=2" "11" "1" "2" "1" "75" "8.8" "10.39" "306.17" "2.87" "1" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02937" "1345" "ENSG00000164919" "COX6C" "B2R4D7; hsa:1345; P09669" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly" "7" "0" "175.0" "153.2" "210.5" "962.8" "361.5" "107.8" "217.2" "192.1" "190.8" "369.7" "411.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82921" "28S ribosomal protein S21, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS21 PE=1 SV=3" "14" "1" "2" "1" "87" "10.7" "9.92" "316.08" "2.87" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01165" "54460" "ENSG00000266472" "MRPS21" "A0A075B746; hsa:54460; P82921; Q5TB11; Q9BST6" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "19.4" "20.8" "28.9" "97.3" "39.4" "19.3" "35.8" "24.9" "24.1" "57.8" "38.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "12" "3" "4" "3" "258" "29.0" "4.83" "1404.52" "2.87" "3" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "360.7" "283.6" "403.5" "838.7" "449.4" "310.8" "643.0" "245.0" "377.9" "992.8" "490.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NWB7" "Intraflagellar transport protein 57 homolog OS=Homo sapiens OX=9606 GN=IFT57 PE=1 SV=1" "3" "1" "2" "1" "429" "49.1" "4.98" "299.95" "2.87" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf10498" "55081" "ENSG00000114446" "IFT57" "hsa:55081; Q96DA9; Q9NWB7" "Intraflagellar transport; Hedgehog 'off' state" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "2" "1" "2" "1" "673" "73.7" "8.98" "270.44" "2.86" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P05089" "Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2" "6" "1" "2" "1" "322" "34.7" "7.21" "429.56" "2.86" "1" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00491" "383" "ENSG00000118520" "ARG1" "A6NEA0; hsa:383; P05089; Q5JWT5; Q5JWT6; Q8TE72; Q9BS50" "Neutrophil degranulation; Urea cycle" "Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "n/a" "High" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "1" "" "False" "IsMasterProtein" "Q6PI98" "INO80 complex subunit C OS=Homo sapiens OX=9606 GN=INO80C PE=1 SV=1" "7" "1" "2" "1" "192" "20.6" "10.02" "473.03" "2.86" "1" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08265" "125476" "ENSG00000153391" "INO80C" "B4DUI4; E9PCS7; hsa:125476; Q6PI98; Q86WR1; Q8N994" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "5.1" "5.8" "6.3" "17.5" "8.3" "5.6" "15.5" "2.5" "7.7" "30.2" "30.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42345" "Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1" "0" "1" "2" "1" "2549" "288.7" "7.17" "312.17" "2.86" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08771, Pf11865" "2475" "ENSG00000198793" "MTOR" "hsa:2475; P42345; Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3" "TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK; Amino acids regulate mTORC1; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; Regulation of PTEN gene transcription; mTORC1-mediated signalling; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; Macroautophagy; HSF1-dependent transactivation" "AMP-activated protein kinase signaling; Target of rapamycin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; TSLP signaling pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM signaling in development and disease ; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; CAMKK2 pathway; Neuroinflammation; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; A network map of Macrophage-stimulating protein (MSP) signaling; JAK-STAT signaling in the regulation of Beta-cells; Interferon type I signaling pathways; ErbB signaling pathway" "85" "0" "11.0" "13.5" "14.9" "44.0" "26.2" "13.9" "17.7" "12.4" "16.3" "29.7" "27.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "2" "1" "2" "1" "631" "73.2" "8.15" "327.39" "2.86" "1" "1" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "11.8" "10.8" "14.5" "30.3" "20.5" "12.7" "21.2" "9.9" "13.7" "40.5" "23.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "5" "2" "3" "2" "499" "55.7" "5.62" "931.23" "2.86" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "4" "0" "203.2" "180.8" "270.8" "1223.5" "482.4" "214.0" "349.6" "224.4" "267.7" "594.4" "432.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "2" "1" "2" "1" "463" "51.8" "5.45" "278.77" "2.85" "1" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "Hijack of ubiquitination by SARS-CoV-2" "5" "0" "3.2" "7.3" "10.3" "54.3" "19.2" "0.3" "4.5" "6.2" "9.8" "16.7" "14.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14874" "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2" "3" "1" "2" "1" "412" "46.3" "8.82" "379.38" "2.85" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "10295" "ENSG00000103507" "BCKDK" "A8MY43; hsa:10295; O14874; Q6FGL4; Q96G95; Q96IN5" "Branched-chain amino acid catabolism" "Thiamine metabolic pathways" "2" "0" "66.6" "90.3" "85.4" "145.1" "107.5" "95.2" "146.1" "82.2" "80.9" "273.2" "159.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "25" "2" "3" "2" "107" "11.7" "10.32" "1048.11" "2.85" "2" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "13" "0" "232.1" "151.5" "220.7" "383.0" "271.2" "184.6" "300.9" "122.9" "228.2" "456.6" "377.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22735" "Protein-glutamine gamma-glutamyltransferase K OS=Homo sapiens OX=9606 GN=TGM1 PE=1 SV=4" "1" "1" "2" "1" "817" "89.7" "6.04" "297.79" "2.84" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00868, Pf00927, Pf01841" "7051" "ENSG00000092295; ENSG00000285348" "TGM1" "B4DWR7; hsa:7051; P22735; Q197M4" "Formation of the cornified envelope" "" "1" "0" "78.8" "59.0" "34.3" "27.6" "16.2" "15.2" "68.9" "15.9" "7.0" "34.6" "30.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z4H7" "HAUS augmin-like complex subunit 6 OS=Homo sapiens OX=9606 GN=HAUS6 PE=1 SV=2" "1" "1" "2" "1" "955" "108.6" "6.47" "251.85" "2.84" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14661" "54801" "ENSG00000147874" "HAUS6" "B3KPK4; B4DX82; hsa:54801; Q05CG1; Q14CB6; Q14CD9; Q2TA91; Q6IQ10; Q6NZX5; Q7Z4H7; Q8IZQ4; Q96FN0; Q9H950; Q9H998; Q9HCJ8; Q9NXT8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "7.5" "8.3" "10.6" "35.7" "19.8" "8.4" "20.5" "12.8" "10.4" "56.7" "55.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "2" "1" "3" "1" "649" "70.9" "7.39" "588.78" "2.84" "1" "1" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "PPARA activates gene expression; NFE2L2 regulating anti-oxidant/detoxification enzymes; Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "n/a" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q92575" "UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2" "3" "1" "2" "1" "508" "56.7" "6.38" "384.01" "2.84" "1" "1" "protein metabolism;other metabolic processes;stress response" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf00789" "23190" "ENSG00000144224" "UBXN4" "A8K9W4; hsa:23190; Q4ZG56; Q8IYM5; Q92575" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0" "2" "2" "1" "8797" "1010.5" "5.53" "251.96" "2.83" "1" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; hsa:23345; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Meiotic synapsis" "Envelope proteins and their potential roles in EDMD physiopathology" "2" "0" "13.4" "12.8" "24.0" "104.6" "38.0" "18.2" "22.1" "24.0" "19.5" "162.7" "429.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14571" "Inositol 1,4,5-trisphosphate receptor type 2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2" "1" "2" "3" "1" "2701" "307.9" "6.43" "584.10" "2.83" "2" "1" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3709" "ENSG00000123104" "ITPR2" "hsa:3709; O94773; Q14571" "Ion homeostasis; Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "1" "3" "4" "3" "5596" "632.4" "5.68" "864.83" "2.82" "3" "1" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867" "23195" "ENSG00000112159; ENSG00000288121" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "56.7" "66.3" "88.1" "336.0" "118.2" "59.4" "106.4" "92.5" "76.9" "430.4" "442.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "5" "1" "2" "1" "247" "27.9" "7.74" "265.96" "2.82" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "24.9" "29.0" "29.1" "78.7" "41.0" "28.8" "35.6" "26.7" "38.0" "120.7" "111.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13144" "Translation initiation factor eIF-2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "2" "1" "2" "1" "721" "80.3" "5.08" "361.81" "2.82" "1" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Recycling of eIF2:GDP" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "5" "0" "12.9" "14.6" "16.1" "45.1" "20.1" "14.1" "33.3" "18.4" "21.6" "93.6" "82.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969S2" "Endonuclease 8-like 2 OS=Homo sapiens OX=9606 GN=NEIL2 PE=1 SV=3" "3" "1" "1" "1" "332" "36.8" "6.79" "" "2.81" "" "1" "DNA metabolism;other metabolic processes;stress response" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf06831" "252969" "ENSG00000154328" "NEIL2" "B4DFR7; hsa:252969; Q7Z3Q7; Q8N842; Q8NG52; Q969S2" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" "Base excision repair; DNA repair pathways, full network; 8p23.1 copy number variation syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WVD3" "E3 ubiquitin-protein ligase RNF138 OS=Homo sapiens OX=9606 GN=RNF138 PE=1 SV=1" "4" "1" "2" "1" "245" "28.2" "6.93" "354.48" "2.80" "1" "1" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05605, Pf13923, Pf18574" "51444" "ENSG00000134758" "RNF138" "B2RE17; hsa:51444; Q8WVD3; Q9H8K2; Q9UF87; Q9UKI6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "29.1" "23.5" "34.7" "98.7" "47.3" "27.5" "51.0" "83.5" "285.4" "1011.3" "758.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WXA9" "Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1" "2" "1" "2" "1" "508" "59.3" "10.39" "281.48" "2.80" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "140890" "ENSG00000153914" "SREK1" "A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9" "" "mRNA processing" "1" "0" "16.5" "9.9" "9.1" "22.4" "16.2" "14.4" "12.5" "8.4" "13.6" "34.1" "30.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "4" "1" "1" "1" "551" "60.2" "5.68" "" "2.80" "" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Senescence-Associated Secretory Phenotype (SASP); Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; SUMOylation of immune response proteins" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; IL-26 signaling pathways; A network map of Macrophage-stimulating protein (MSP) signaling; Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "97" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "1" "" "False" "IsMasterProtein" "O95359" "Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3" "1" "1" "1" "1" "2948" "309.2" "4.79" "" "2.80" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05010" "10579" "ENSG00000138162" "TACC2" "hsa:10579; O95359; Q4VXL0; Q4VXL3; Q4VXL6; Q4VXL7; Q5U5T7; Q86WG6; Q86WG7; Q8TCK9; Q9BVQ1; Q9NZ41; Q9NZR5" "" "" "0" "0" "17.6" "25.7" "17.7" "43.9" "27.7" "18.2" "27.7" "19.9" "27.9" "193.8" "421.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60942" "mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1" "2" "1" "2" "1" "597" "68.5" "8.13" "345.12" "2.79" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00782, Pf01331, Pf03919" "8732" "ENSG00000111880" "RNGTT" "E1P513; E1P514; hsa:8732; O43483; O60257; O60351; O60942; Q5TCW8; Q8WUM8" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "mRNA processing; Ciliary landscape" "5" "0" "21.4" "16.9" "24.2" "56.0" "29.9" "22.7" "33.5" "22.7" "21.2" "71.3" "61.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "5" "2" "3" "2" "390" "43.9" "6.46" "362.66" "2.79" "1" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "7" "0" "0.0" "4.4" "2.3" "11.5" "3.7" "2.7" "0.0" "4.0" "3.5" "29.4" "80.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "12" "2" "3" "2" "214" "22.1" "8.70" "928.32" "2.79" "2" "1" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "" "Selenium micronutrient network" "1" "0" "87.8" "94.8" "162.0" "880.7" "282.9" "53.6" "138.0" "130.9" "87.0" "208.0" "157.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86YB8" "ERO1-like protein beta OS=Homo sapiens OX=9606 GN=ERO1B PE=1 SV=2" "2" "1" "2" "1" "467" "53.5" "7.99" "251.42" "2.79" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf04137" "56605" "ENSG00000086619" "ERO1B" "B4DF57; hsa:56605; Q5T1H4; Q86YB8; Q8IZ11; Q9NR62" "Insulin processing" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43402" "ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1" "4" "1" "1" "1" "210" "23.8" "6.40" "" "2.78" "" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf03665" "10328" "ENSG00000131148" "EMC8" "C9JB21; hsa:10328; O43402" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "3" "1" "2" "1" "471" "52.0" "8.00" "277.40" "2.78" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; RHOBTB1 GTPase cycle" "" "5" "0" "50.1" "38.8" "49.2" "116.0" "56.2" "46.8" "70.3" "44.6" "56.1" "106.0" "72.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96DV4" "39S ribosomal protein L38, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "2" "1" "2" "1" "380" "44.6" "7.53" "309.83" "2.78" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "86.4" "76.7" "126.7" "421.7" "199.8" "71.9" "173.4" "123.3" "106.7" "334.2" "376.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13191" "E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens OX=9606 GN=CBLB PE=1 SV=2" "2" "1" "2" "1" "982" "109.4" "7.88" "314.99" "2.78" "1" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02262, Pf02761, Pf02762, Pf14447" "868" "ENSG00000114423" "CBLB" "A8K9S7; B7WNM4; hsa:868; Q13191; Q13192; Q13193; Q3LIC0; Q63Z43; Q8IVC5" "Antigen processing: Ubiquitination & Proteasome degradation" "Angiopoietin-like protein 8 regulatory pathway; Fibrin complement receptor 3 signaling pathway; EGF/EGFR signaling pathway; Measles virus infection; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor signaling pathway" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "6" "3" "5" "3" "627" "70.7" "8.56" "927.15" "2.78" "3" "2" "transport;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "57.0" "45.0" "77.4" "225.8" "97.7" "63.8" "115.0" "58.4" "68.2" "190.8" "190.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "10" "2" "3" "1" "205" "22.7" "6.21" "671.19" "2.77" "2" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "0" "19.7" "19.6" "27.3" "141.6" "51.7" "16.7" "25.1" "26.6" "22.1" "81.9" "71.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "2" "1" "2" "1" "388" "41.8" "8.90" "255.94" "2.77" "1" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "" "Adipogenesis" "1" "0" "68.6" "62.4" "96.0" "234.8" "100.5" "85.4" "179.8" "88.0" "94.1" "355.8" "292.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A6ZKI3" "Retrotransposon Gag-like protein 8C OS=Homo sapiens OX=9606 GN=RTL8C PE=1 SV=1" "11" "1" "1" "1" "113" "13.2" "5.07" "" "2.77" "" "1" "" "" "" "Pf16297" "8933" "ENSG00000134590" "RTL8C" "A6ZKI3; hsa:8933" "" "" "0" "0" "30.9" "33.1" "43.9" "121.7" "52.6" "40.1" "57.4" "49.0" "47.9" "205.5" "245.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "2" "1" "2" "1" "651" "72.8" "7.44" "318.05" "2.77" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway" "" "3" "0" "11.9" "6.8" "11.0" "20.5" "13.6" "9.8" "17.7" "13.8" "11.5" "48.0" "40.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14578" "Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2" "1" "1" "2" "1" "2027" "231.3" "6.57" "306.07" "2.76" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00780" "11113" "ENSG00000122966" "CIT" "hsa:11113; O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate CIT" "Pleural mesothelioma; G13 signaling pathway" "7" "0" "6.5" "7.1" "7.0" "28.4" "12.1" "2.8" "16.9" "11.6" "12.8" "54.5" "38.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43598" "2'-deoxynucleoside 5'-phosphate N-hydrolase 1 OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "6" "1" "2" "1" "174" "19.1" "5.05" "317.94" "2.76" "1" "1" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "Purine catabolism" "" "1" "0" "20.9" "25.2" "57.0" "328.8" "101.4" "11.5" "36.3" "49.3" "36.5" "85.4" "114.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "5" "1" "2" "1" "147" "15.9" "8.21" "336.20" "2.76" "1" "1" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "127.2" "119.4" "156.0" "323.7" "174.7" "129.2" "302.3" "91.2" "118.8" "327.0" "136.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A0A087WV53" "SPEG neighbor protein OS=Homo sapiens OX=9606 GN=SPEGNB PE=4 SV=1" "7" "1" "1" "1" "238" "26.1" "5.60" "" "2.76" "" "1" "" "" "" "Pf00612, Pf07679" "100996693" "ENSG00000286095" "SPEGNB" "A0A087WV53; hsa:100996693" "" "" "0" "0" "26.4" "21.3" "54.0" "205.1" "90.2" "39.3" "71.6" "38.4" "52.1" "114.2" "95.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2G9" "Protein strawberry notch homolog 2 OS=Homo sapiens OX=9606 GN=SBNO2 PE=2 SV=3" "1" "1" "1" "1" "1366" "150.2" "6.52" "" "2.75" "" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "22904" "ENSG00000064932; ENSG00000278788" "SBNO2" "A8K8P2; B3KWJ1; hsa:22904; O75257; Q3KQX0; Q8TEM0; Q9Y2G9" "" "" "0" "0" "92.7" "62.6" "92.1" "171.8" "105.7" "72.7" "122.6" "58.7" "67.8" "131.4" "87.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "1" "1" "2" "1" "1132" "119.3" "5.60" "326.58" "2.75" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "7.7" "10.6" "15.1" "66.0" "28.9" "5.3" "15.4" "16.0" "13.0" "25.2" "18.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "5" "1" "2" "1" "249" "28.4" "9.23" "325.47" "2.75" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "Eukaryotic transcription initiation" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BXF6" "Rab11 family-interacting protein 5 OS=Homo sapiens OX=9606 GN=RAB11FIP5 PE=1 SV=1" "1" "1" "2" "1" "653" "70.4" "9.23" "293.26" "2.74" "1" "1" "cell-cell signaling;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00168, Pf09457" "26056" "ENSG00000135631" "RAB11FIP5" "hsa:26056; O94939; Q9BXF6; Q9P0M1" "" "" "0" "0" "42.6" "39.4" "48.1" "108.4" "59.7" "44.0" "77.9" "67.4" "155.7" "320.8" "214.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82932" "28S ribosomal protein S6, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3" "10" "1" "2" "1" "125" "14.2" "9.26" "333.56" "2.74" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01250" "64968" "ENSG00000243927" "MRPS6" "B2R573; hsa:64968; P82932; Q96Q64; Q9BSK8; Q9BW89" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "18.1" "23.5" "24.1" "131.0" "41.4" "16.6" "41.1" "34.0" "25.7" "98.6" "96.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48449" "Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1" "1" "1" "2" "1" "732" "83.3" "6.61" "369.17" "2.74" "1" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00432" "4047" "ENSG00000160285" "LSS" "B4DJZ9; D3DSN0; E9PEI9; G5E9Q9; hsa:4047; P48449; Q8IYL6; Q9UEZ1" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "18.9" "12.6" "25.2" "138.1" "48.1" "13.9" "25.9" "19.5" "21.8" "49.9" "53.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "2" "1" "2" "1" "601" "63.8" "5.22" "298.41" "2.73" "1" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "0" "11.3" "13.4" "18.8" "225.4" "50.0" "23.5" "20.4" "17.8" "10.5" "36.5" "35.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "3" "1" "2" "1" "339" "40.2" "6.83" "289.59" "2.73" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "mRNA Splicing - Major Pathway" "" "1" "0" "24.0" "21.8" "40.1" "122.2" "61.9" "34.0" "47.6" "31.7" "45.7" "92.8" "73.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0" "1" "2" "1" "3114" "357.3" "5.10" "264.89" "2.73" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Polo-like kinase mediated events" "Gastric cancer network 1; Ciliopathies" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "3" "1" "2" "1" "429" "48.7" "5.60" "359.19" "2.72" "1" "1" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Neutrophil degranulation; Glycosphingolipid metabolism" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "4" "0" "12.5" "12.5" "16.5" "57.5" "22.0" "8.9" "12.0" "10.8" "8.8" "19.3" "20.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "5" "2" "3" "2" "483" "57.7" "9.48" "749.96" "2.72" "2" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "6" "0" "53.0" "47.6" "61.5" "196.0" "100.0" "60.3" "108.2" "58.2" "74.1" "207.5" "139.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00257" "E3 SUMO-protein ligase CBX4 OS=Homo sapiens OX=9606 GN=CBX4 PE=1 SV=3" "4" "1" "2" "1" "560" "61.3" "9.36" "263.60" "2.71" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00385, Pf17218" "8535" "ENSG00000141582" "CBX4" "B1PJR7; hsa:8535; O00257; Q6TPI8; Q96C04" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "n/a" "n/a" "High" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "1" "1" "2" "1" "1498" "167.3" "5.44" "326.02" "2.71" "1" "1" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "RND2 GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "3" "1" "2" "1" "455" "50.6" "9.10" "285.66" "2.71" "1" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "10.4" "12.8" "14.7" "25.7" "17.4" "11.0" "21.3" "13.2" "11.7" "43.6" "52.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "2" "1" "2" "1" "479" "52.6" "5.05" "337.25" "2.71" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "MAPK signaling pathway" "4" "0" "42.0" "23.8" "41.7" "67.3" "47.7" "29.1" "61.1" "24.1" "35.4" "49.6" "22.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O76094" "Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3" "2" "1" "2" "1" "671" "74.6" "9.26" "263.19" "2.71" "1" "1" "transport" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08492, Pf13181, Pf17004" "6731" "ENSG00000174780" "SRP72" "G5E9Z8; hsa:6731; O76094; Q7Z3C0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "8.9" "3.4" "9.9" "35.7" "14.1" "8.7" "16.9" "7.5" "5.8" "32.9" "29.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "2" "1" "1" "1" "650" "72.5" "8.05" "" "2.71" "" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207, Pf18044" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "2.9" "3.4" "6.1" "16.7" "8.1" "3.4" "12.6" "6.6" "8.5" "37.6" "19.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5M8" "Signal recognition particle receptor subunit beta OS=Homo sapiens OX=9606 GN=SRPRB PE=1 SV=3" "4" "1" "2" "1" "271" "29.7" "9.04" "306.92" "2.70" "1" "1" "cell organization and biogenesis;transport" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09439" "58477" "ENSG00000144867" "SRPRB" "hsa:58477; Q6P595; Q8N2D8; Q9Y5M8" "SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P53007" "Tricarboxylate transport protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A1 PE=1 SV=2" "4" "1" "2" "1" "311" "34.0" "9.89" "235.97" "2.70" "1" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00153" "6576" "ENSG00000100075" "SLC25A1" "A8K8E8; hsa:6576; P53007; Q9BSK6" "Gluconeogenesis; Fatty acyl-CoA biosynthesis" "22q11.2 copy number variation syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "4" "1" "2" "1" "356" "40.0" "7.05" "350.77" "2.70" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Neutrophil degranulation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T0U0" "Coiled-coil domain-containing protein 122 OS=Homo sapiens OX=9606 GN=CCDC122 PE=2 SV=1" "4" "1" "1" "1" "273" "32.2" "7.01" "" "2.70" "" "1" "" "" "" "" "160857" "ENSG00000151773" "CCDC122" "B2RP70; B7ZMI9; hsa:160857; Q5T0U0; Q96MV0" "" "" "0" "0" "122.5" "99.3" "175.2" "417.3" "248.0" "161.3" "302.9" "125.8" "170.0" "442.9" "221.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "4" "1" "2" "1" "494" "55.0" "7.12" "295.20" "2.69" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "Formation of the active cofactor, UDP-glucuronate" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "n/a" "1" "" "False" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "21" "3" "4" "3" "144" "17.0" "8.82" "1297.06" "2.69" "3" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "mRNA Splicing - Major Pathway" "" "1" "0" "104.8" "82.3" "96.7" "276.6" "134.6" "86.3" "154.8" "90.5" "175.0" "1235.8" "1436.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRW7" "Vacuolar protein sorting-associated protein 45 OS=Homo sapiens OX=9606 GN=VPS45 PE=1 SV=1" "2" "1" "2" "1" "570" "65.0" "8.24" "240.08" "2.69" "1" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf00995" "11311" "ENSG00000136631" "VPS45" "D3DUZ9; F5H8K1; hsa:11311; Q15715; Q53FR8; Q5T4P6; Q9NRW7; Q9Y4Z6" "Intra-Golgi traffic; Factors involved in megakaryocyte development and platelet production; SARS-CoV-2 modulates autophagy" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "7" "1" "1" "1" "282" "31.5" "5.52" "" "2.69" "" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HDC5" "Junctophilin-1 OS=Homo sapiens OX=9606 GN=JPH1 PE=1 SV=2" "2" "1" "2" "1" "661" "71.6" "9.32" "298.68" "2.69" "1" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf02493" "56704" "ENSG00000104369" "JPH1" "B2RTZ0; hsa:56704; Q9HDC5" "" "" "0" "0" "57.1" "48.7" "70.4" "222.6" "88.8" "67.9" "118.1" "71.2" "90.9" "346.1" "207.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "1" "1" "2" "1" "737" "80.9" "5.83" "250.77" "2.69" "1" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "" "3" "0" "100.9" "87.9" "109.5" "278.2" "142.2" "98.3" "165.3" "71.4" "105.5" "225.1" "143.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "1" "1" "2" "1" "1038" "119.4" "4.82" "292.69" "2.69" "1" "1" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "2.9" "5.6" "4.1" "30.6" "10.9" "2.6" "10.5" "8.7" "1.3" "37.4" "45.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "3" "1" "2" "1" "564" "62.3" "6.99" "274.32" "2.68" "1" "1" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Coenzyme A biosynthesis" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H583" "HEAT repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=HEATR1 PE=1 SV=3" "1" "1" "2" "1" "2144" "242.2" "6.54" "245.90" "2.68" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf08146, Pf12397" "55127" "ENSG00000119285" "HEATR1" "hsa:55127; Q5T3Q8; Q6P197; Q9H583; Q9NW23" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "6.9" "4.8" "8.6" "21.0" "15.1" "11.5" "14.9" "8.6" "8.8" "19.3" "16.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07686" "Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=3" "2" "1" "2" "1" "556" "63.1" "6.76" "325.85" "2.67" "1" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00728, Pf14845" "3074" "" "HEXB" "A0A024RAJ6; hsa:3074" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49419" "Alpha-aminoadipic semialdehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH7A1 PE=1 SV=5" "3" "1" "2" "1" "539" "58.5" "7.99" "367.14" "2.67" "1" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "501" "ENSG00000164904" "ALDH7A1" "B2R669; B4DIC7; B4DMA0; E7EPT3; hsa:501; O14619; P49419; Q6IPU8; Q9BUL4" "Lysine catabolism; Choline catabolism" "Amino acid metabolism; Vitamin B6-dependent and responsive disorders; Cerebral organic acidurias, including diseases; Diet-dependent trimethylamine/trimethylamine N-oxide metabolism" "6" "0" "3.8" "7.5" "8.4" "44.6" "16.7" "5.2" "13.2" "7.5" "6.3" "32.9" "19.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "2" "1" "2" "1" "654" "74.3" "6.89" "287.52" "2.67" "1" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "7" "1" "1" "1" "169" "19.4" "8.81" "" "2.66" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "" "Metapathway biotransformation Phase I and II" "1" "0" "44.2" "41.7" "64.3" "188.8" "84.2" "45.5" "85.6" "55.2" "57.1" "214.2" "247.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75569" "Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1" "3" "1" "2" "1" "313" "34.4" "8.41" "242.84" "2.66" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035" "8575" "ENSG00000180228" "PRKRA" "A8K3I6; hsa:8575; O75569; Q53G24; Q6X7T5; Q8NDK4" "MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "VEGFA-VEGFR2 signaling; Ebola virus infection in host" "4" "0" "15.9" "18.7" "25.9" "48.1" "22.4" "23.0" "38.7" "18.9" "18.3" "49.3" "32.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "2" "1" "2" "1" "432" "48.5" "6.54" "314.89" "2.66" "1" "1" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; IL-18 signaling pathway" "24" "0" "99.6" "94.5" "102.5" "179.6" "115.9" "83.2" "129.5" "78.9" "129.6" "483.3" "554.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "1" "1" "2" "1" "907" "103.5" "8.12" "244.74" "2.66" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "15q11.2 copy number variation syndrome" "3" "0" "15.5" "17.1" "16.4" "54.6" "22.1" "17.3" "28.9" "15.9" "20.9" "101.6" "89.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRY4" "Rho GTPase-activating protein 35 OS=Homo sapiens OX=9606 GN=ARHGAP35 PE=1 SV=3" "1" "1" "2" "1" "1499" "170.4" "6.64" "286.30" "2.66" "1" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00071, Pf00620, Pf01846, Pf16512, Pf19518" "2909" "ENSG00000160007" "ARHGAP35" "A7E2A4; hsa:2909; Q14452; Q9C0E1; Q9NRY4" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Sema4D mediated inhibition of cell attachment and migration; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "Focal adhesion; Regulation of actin cytoskeleton" "18" "0" "0.0" "4.0" "9.2" "22.8" "9.7" "5.8" "7.8" "6.4" "3.6" "23.3" "61.8" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "3" "1" "2" "1" "346" "36.9" "6.87" "265.66" "2.66" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "26.2" "26.4" "36.2" "143.7" "49.5" "27.0" "48.3" "42.6" "36.5" "128.6" "114.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VUA4" "Zinc finger protein 318 OS=Homo sapiens OX=9606 GN=ZNF318 PE=1 SV=2" "1" "2" "3" "2" "2279" "251.0" "7.20" "552.66" "2.65" "2" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "24149" "ENSG00000171467" "ZNF318" "hsa:24149; O94796; Q4G0E4; Q5VUA4; Q8NEM6; Q9UNU8; Q9Y2W9" "" "Androgen receptor signaling pathway" "1" "0" "23.0" "26.1" "26.7" "58.3" "35.1" "26.2" "55.1" "31.0" "37.6" "133.7" "88.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P07951" "Tropomyosin beta chain OS=Homo sapiens OX=9606 GN=TPM2 PE=1 SV=1" "11" "3" "4" "1" "284" "32.8" "4.70" "1137.23" "2.65" "3" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7169" "ENSG00000198467" "TPM2" "A6NM85; hsa:7169; P06468; P07951; Q13894; Q53FM4; Q5TCU4; Q5TCU7; Q9UH67" "Striated Muscle Contraction; Smooth Muscle Contraction" "Striated muscle contraction pathway" "3" "0" "9.8" "6.1" "10.8" "52.3" "21.3" "5.7" "9.7" "9.3" "11.2" "9.7" "10.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRP1" "Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1" "5" "1" "1" "1" "358" "39.4" "4.86" "" "2.65" "" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf04194" "84306" "ENSG00000126249" "PDCD2L" "hsa:84306; Q9BRP1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P56381" "ATP synthase subunit epsilon, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1E PE=1 SV=2" "29" "2" "3" "2" "51" "5.8" "9.92" "533.08" "2.65" "2" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "514" "ENSG00000124172" "ATP5F1E" "B2RDD0; E1P5H6; hsa:514; P56381; Q53XU6" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "204.6" "196.7" "222.5" "631.6" "264.3" "148.7" "292.0" "177.9" "229.4" "515.6" "446.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95835" "Serine/threonine-protein kinase LATS1 OS=Homo sapiens OX=9606 GN=LATS1 PE=1 SV=1" "1" "1" "2" "1" "1130" "126.8" "8.70" "348.79" "2.64" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00627" "9113" "ENSG00000131023" "LATS1" "hsa:9113; O95835; Q6PKD0" "Signaling by Hippo" "Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "9" "0" "8.4" "8.9" "13.1" "19.8" "12.7" "4.7" "16.2" "6.5" "15.0" "16.3" "10.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95168" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 OS=Homo sapiens OX=9606 GN=NDUFB4 PE=1 SV=3" "8" "1" "2" "1" "129" "15.2" "9.85" "289.63" "2.64" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion;nucleus" "transporter activity" "Pf07225" "4710" "ENSG00000065518" "NDUFB4" "B2RUY3; B9EJC7; hsa:4710; O95168" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "40.7" "39.1" "47.7" "159.2" "69.0" "45.3" "69.9" "52.5" "91.5" "479.3" "401.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z4Q2" "HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2" "2" "1" "2" "1" "680" "74.5" "5.11" "316.32" "2.64" "1" "1" "transport;other biological processes" "" "other molecular function" "Pf13513" "55027" "ENSG00000155393" "HEATR3" "A8K1N4; hsa:55027; Q7Z4Q2; Q8N525; Q8WV56; Q96CC9; Q9NWN7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "4" "1" "2" "1" "446" "50.4" "9.63" "439.12" "2.64" "1" "1" "" "nucleus" "" "Pf01585" "" "" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "21.1" "19.2" "23.9" "36.2" "23.1" "20.7" "34.2" "11.2" "22.4" "69.3" "46.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "2" "1" "1" "1" "517" "57.4" "6.76" "" "2.64" "" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Purine ribonucleoside monophosphate biosynthesis" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15357" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2" "1" "1" "2" "1" "1258" "138.5" "6.54" "357.77" "2.64" "1" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00017, Pf00536, Pf03372" "3636" "ENSG00000165458" "INPPL1" "B2RTX5; hsa:3636; O15357; Q13577; Q13578" "Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells" "EGF/EGFR signaling pathway; Insulin signaling" "6" "0" "12.6" "26.7" "28.3" "131.8" "48.6" "14.9" "30.3" "27.3" "21.7" "89.5" "142.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q05519" "Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1" "2" "1" "2" "1" "484" "53.5" "10.52" "337.06" "2.64" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00076" "9295" "ENSG00000116754" "SRSF11" "hsa:9295; Q05519; Q5T758; Q8IWE6" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "5" "0" "139.0" "124.5" "215.2" "701.2" "321.6" "107.7" "293.6" "190.2" "201.5" "485.0" "420.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15643" "Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3" "0" "1" "2" "1" "1979" "227.4" "5.26" "237.90" "2.63" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes" "other membranes;cytoskeleton;ER/Golgi" "other molecular function" "" "9321" "ENSG00000100815" "TRIP11" "B2RUT2; hsa:9321; O14689; O15154; O95949; Q15643; Q6MZL5" "Intra-Golgi traffic; Intraflagellar transport; Signaling by FLT3 fusion proteins" "" "3" "0" "179.0" "112.3" "147.5" "278.2" "213.6" "153.7" "217.9" "122.8" "188.7" "261.9" "185.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P16219" "Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADS PE=1 SV=1" "3" "1" "2" "1" "412" "44.3" "7.99" "275.66" "2.63" "1" "1" "other metabolic processes" "cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "35" "ENSG00000122971" "ACADS" "hsa:35; P16219; P78331" "Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "8" "1" "2" "1" "83" "9.3" "5.12" "284.39" "2.63" "1" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "Mitochondrial protein import" "" "1" "0" "124.7" "98.2" "179.0" "621.6" "227.2" "106.9" "302.9" "103.0" "178.0" "666.9" "554.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "3" "2" "3" "2" "572" "62.3" "6.38" "513.58" "2.63" "2" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Recycling pathway of L1; CRMPs in Sema3A signaling" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "4" "0" "31.9" "36.1" "44.1" "247.4" "81.7" "24.3" "60.3" "42.8" "67.6" "291.4" "274.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=2" "2" "1" "2" "1" "633" "69.4" "6.39" "335.18" "2.62" "1" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "65.9" "56.3" "68.7" "202.8" "94.4" "63.1" "90.5" "57.2" "72.8" "228.5" "175.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "3" "1" "2" "1" "298" "32.8" "9.57" "311.85" "2.62" "1" "1" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "Base excision repair; DNA repair pathways, full network" "5" "0" "126.4" "108.8" "123.3" "232.6" "143.2" "122.9" "210.1" "117.1" "104.6" "344.6" "310.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "3" "1" "1" "1" "376" "40.1" "5.27" "" "2.62" "" "1" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P56545" "C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1" "2" "1" "2" "1" "445" "48.9" "6.95" "281.96" "2.62" "1" "1" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1488" "ENSG00000175029" "CTBP2" "A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8" "Repression of WNT target genes; Signaling by TCF7L2 mutants" "Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma" "11" "0" "74.7" "57.5" "77.9" "330.5" "121.1" "52.0" "100.6" "66.1" "76.7" "228.7" "164.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00483" "Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens OX=9606 GN=NDUFA4 PE=1 SV=1" "12" "1" "2" "1" "81" "9.4" "9.38" "277.54" "2.62" "1" "1" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf06522" "4697" "ENSG00000189043" "NDUFA4" "A4D109; hsa:4697; O00483; Q6FHN5" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation" "7" "0" "77.2" "74.4" "102.8" "342.6" "164.1" "79.7" "129.7" "85.7" "102.7" "276.6" "220.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "1" "1" "2" "1" "759" "84.5" "7.23" "280.20" "2.62" "1" "1" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "RAC2 GTPase cycle; RAC3 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "Integrin-mediated cell adhesion" "9" "0" "14.8" "11.8" "11.0" "24.2" "12.9" "10.7" "19.0" "14.5" "15.5" "40.1" "32.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51114" "Fragile X mental retardation syndrome-related protein 1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "4" "2" "3" "1" "621" "69.7" "6.15" "974.76" "2.62" "2" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Signaling by BRAF and RAF1 fusions" "Bile acids synthesis and enterohepatic circulation" "2" "0" "40.7" "37.1" "54.1" "168.0" "78.9" "51.0" "80.9" "48.6" "48.4" "119.3" "86.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51116" "Fragile X mental retardation syndrome-related protein 2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2" "4" "2" "3" "1" "673" "74.2" "6.23" "881.09" "2.62" "2" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf17904, Pf18336" "9513" "ENSG00000129245" "FXR2" "B2R9M2; D3DTQ1; hsa:9513; P51116; Q86V09; Q8WUM2" "" "VEGFA-VEGFR2 signaling" "1" "0" "11.6" "12.9" "13.8" "48.9" "22.5" "15.8" "25.3" "16.5" "17.8" "57.4" "29.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "1" "1" "2" "1" "802" "85.1" "6.79" "325.82" "2.62" "1" "1" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "4" "1" "2" "1" "238" "27.4" "11.82" "314.06" "2.62" "1" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript" "mRNA processing" "7" "0" "41.2" "52.9" "70.6" "288.0" "91.4" "32.3" "121.1" "82.3" "49.1" "245.5" "170.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "4" "1" "2" "1" "258" "29.0" "5.81" "322.49" "2.61" "1" "1" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Neutrophil degranulation; Intra-Golgi traffic" "Ciliary landscape; 22q11.2 copy number variation syndrome" "4" "0" "14.5" "12.1" "24.3" "77.1" "25.9" "10.6" "39.6" "20.7" "22.8" "58.3" "46.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "2" "1" "2" "1" "715" "80.7" "9.26" "315.71" "2.61" "1" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60784" "Target of Myb protein 1 OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "3" "1" "3" "1" "492" "53.8" "4.70" "750.30" "2.61" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "Neutrophil degranulation" "" "1" "0" "7.1" "8.1" "5.6" "31.8" "15.0" "2.7" "8.5" "7.4" "10.1" "30.9" "23.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "6" "3" "4" "3" "514" "58.7" "6.43" "936.79" "2.61" "3" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "Selenocysteine synthesis; Cytosolic tRNA aminoacylation" "VEGFA-VEGFR2 signaling" "3" "0" "161.0" "157.1" "197.4" "867.8" "334.7" "111.8" "198.1" "176.1" "169.9" "332.4" "369.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "1" "1" "2" "1" "2243" "254.3" "6.74" "306.88" "2.61" "1" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "Neutrophil degranulation" "" "1" "0" "18.8" "27.1" "34.3" "65.3" "43.0" "25.4" "39.7" "25.2" "29.1" "94.6" "67.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "2" "1" "2" "1" "488" "52.7" "5.68" "301.82" "2.60" "1" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "11p11.2 copy number variation syndrome" "1" "0" "62.4" "51.1" "93.8" "292.7" "141.8" "48.4" "112.7" "72.5" "89.2" "241.4" "194.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00568" "Adenylate kinase isoenzyme 1 OS=Homo sapiens OX=9606 GN=AK1 PE=1 SV=3" "8" "1" "1" "1" "194" "21.6" "8.63" "" "2.60" "" "1" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf00406" "203" "ENSG00000106992" "AK1" "hsa:203; P00568; Q9BVK9; Q9UQC7" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "13.3" "13.7" "19.7" "48.1" "23.0" "18.4" "24.5" "5.5" "14.6" "24.7" "13.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N3R9" "MAGUK p55 subfamily member 5 OS=Homo sapiens OX=9606 GN=MPP5 PE=1 SV=3" "2" "1" "2" "1" "675" "77.2" "6.14" "263.02" "2.59" "1" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00595, Pf00625, Pf02828, Pf07653, Pf09060" "64398" "ENSG00000072415" "PALS1" "A1L380; hsa:64398; Q7Z631; Q86T98; Q8N3R9; Q8N7I5; Q9H9Q0" "Tight junction interactions; SARS-CoV-2 targets PDZ proteins in cell-cell junction; SARS-CoV-1 targets PDZ proteins in cell-cell junction" "Epithelial to mesenchymal transition in colorectal cancer; Complement system in neuronal development and plasticity" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "n/a" "n/a" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92560" "Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2" "1" "1" "2" "1" "729" "80.3" "6.84" "313.45" "2.59" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01088, Pf18031" "8314" "ENSG00000163930" "BAP1" "A8K993; hsa:8314; Q6LEM0; Q7Z5E8; Q92560" "UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "Clear cell renal cell carcinoma pathways; Pleural mesothelioma; Kleefstra syndrome" "5" "0" "24.9" "26.9" "36.3" "133.1" "57.6" "31.4" "72.1" "34.1" "40.1" "160.0" "125.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "5" "1" "1" "1" "425" "47.8" "5.68" "" "2.59" "" "1" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "4" "1" "2" "1" "271" "31.3" "4.94" "293.75" "2.59" "1" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "Ub-specific processing proteases; Ovarian tumor domain proteases" "" "2" "0" "25.3" "23.5" "37.4" "136.6" "72.0" "21.8" "37.1" "24.1" "25.8" "62.8" "47.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "8" "1" "2" "1" "134" "15.3" "4.53" "454.27" "2.58" "1" "1" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "32.8" "38.5" "74.0" "625.4" "135.4" "10.1" "80.5" "37.7" "54.6" "119.2" "75.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "1" "1" "2" "1" "1849" "206.8" "6.52" "273.00" "2.58" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "6.2" "0.0" "6.9" "33.6" "12.1" "9.0" "10.3" "5.0" "5.6" "41.0" "46.4" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "5" "1" "2" "1" "227" "25.6" "9.16" "297.68" "2.58" "1" "1" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "Factors involved in megakaryocyte development and platelet production" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NEY1" "Neuron navigator 1 OS=Homo sapiens OX=9606 GN=NAV1 PE=1 SV=2" "1" "1" "2" "1" "1877" "202.3" "8.07" "266.31" "2.58" "1" "1" "cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "" "" "89796" "ENSG00000134369" "NAV1" "A8MS88; hsa:89796; Q5SVH1; Q5SVH2; Q5SVH3; Q5SVH7; Q5VUY9; Q8IVL2; Q8NEY1; Q96II1; Q9H7V9; Q9H9S9; Q9H9T5; Q9UGI1; Q9ULK7; Q9ULR9" "" "" "0" "0" "26.7" "18.6" "23.3" "46.7" "20.7" "20.9" "19.7" "17.0" "21.7" "56.7" "42.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86V48" "Leucine zipper protein 1 OS=Homo sapiens OX=9606 GN=LUZP1 PE=1 SV=2" "1" "1" "2" "1" "1076" "120.2" "8.50" "357.04" "2.58" "1" "1" "developmental processes" "cytoskeleton;nucleus;other cell component" "" "" "7798" "ENSG00000169641" "LUZP1" "hsa:7798; Q5TH93; Q86V48; Q8N4X3; Q8TEH1" "" "Orexin receptor pathway" "1" "0" "96.8" "83.5" "85.7" "160.8" "115.0" "96.8" "128.5" "74.8" "112.9" "236.7" "176.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q4U2R6" "39S ribosomal protein L51, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL51 PE=1 SV=1" "9" "1" "3" "1" "128" "15.1" "11.27" "674.54" "2.58" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10244" "51258" "ENSG00000111639" "MRPL51" "hsa:51258; Q4U2R6; Q96Q57; Q9BQ36; Q9P0N7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "24.7" "29.4" "32.8" "130.6" "51.8" "15.3" "62.5" "27.8" "26.4" "143.1" "134.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15058" "Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1" "0" "1" "2" "1" "1648" "186.4" "7.91" "307.74" "2.58" "1" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf16183" "9928" "ENSG00000118193" "KIF14" "hsa:9928; Q14CI8; Q15058; Q4G0A5; Q5T1W3" "RND2 GTPase cycle; RND1 GTPase cycle; RHO GTPases activate CIT" "" "3" "0" "68.0" "46.7" "83.0" "210.0" "106.7" "73.8" "114.2" "104.2" "224.0" "563.5" "441.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P0DKV0" "Putative spermatogenesis-associated protein 31C1 OS=Homo sapiens OX=9606 GN=SPATA31C1 PE=5 SV=1" "2" "1" "1" "1" "1188" "130.4" "9.42" "" "2.57" "" "1" "other biological processes" "other membranes" "" "Pf14650, Pf15371" "441452" "" "SPATA31C1" "hsa:441452; P0DKV0" "" "" "0" "0" "32.5" "40.4" "95.5" "316.2" "117.9" "69.3" "122.4" "24.5" "46.7" "217.1" "81.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VT66" "Mitochondrial amidoxime-reducing component 1 OS=Homo sapiens OX=9606 GN=MTARC1 PE=1 SV=1" "2" "1" "2" "1" "337" "37.5" "8.88" "263.16" "2.57" "1" "1" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf03473, Pf03476" "64757" "ENSG00000186205" "MTARC1" "A8K447; B2D078; hsa:64757; Q5VT66; Q5VVS9; Q5VVT0; Q5VVT1; Q8N9P5; Q96FN8; Q9H6C7" "Phase I - Functionalization of compounds" "" "1" "0" "32.1" "30.0" "42.9" "176.8" "70.3" "24.8" "73.2" "42.2" "56.3" "195.5" "171.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "6" "1" "1" "1" "172" "18.8" "5.69" "" "2.57" "" "1" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "2.9" "5.3" "8.9" "78.1" "16.1" "5.3" "6.4" "6.9" "7.3" "8.3" "9.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y399" "28S ribosomal protein S2, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "2" "1" "2" "1" "296" "33.2" "9.26" "308.25" "2.57" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "174.2" "148.4" "193.6" "529.7" "257.6" "155.7" "260.0" "151.4" "167.0" "457.4" "325.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0" "1" "2" "1" "2813" "307.4" "5.24" "275.33" "2.56" "1" "1" "transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; NRAGE signals death through JNK; RHOB GTPase cycle" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28702" "Retinoic acid receptor RXR-beta OS=Homo sapiens OX=9606 GN=RXRB PE=1 SV=2" "2" "1" "2" "1" "533" "56.9" "8.18" "232.56" "2.56" "1" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "6257" "ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712" "RXRB" "hsa:6257; P28702; P28703; Q59G65; Q5JP92; Q5STQ1" "PPARA activates gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A and carotenoid metabolism" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96DY2" "Dynein regulatory complex protein 10 OS=Homo sapiens OX=9606 GN=IQCD PE=1 SV=2" "2" "1" "2" "1" "449" "52.3" "9.25" "300.86" "2.56" "1" "1" "" "cytoskeleton;other cell component" "" "Pf00612" "115811" "ENSG00000166578" "IQCD" "hsa:115811; Q6ZSU0; Q96DY2" "" "" "0" "0" "69.0" "80.0" "139.6" "512.1" "215.9" "65.8" "163.2" "112.7" "156.7" "356.6" "319.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96S15" "GATOR complex protein WDR24 OS=Homo sapiens OX=9606 GN=WDR24 PE=1 SV=2" "1" "1" "2" "1" "790" "88.2" "6.52" "388.66" "2.56" "1" "1" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00400" "84219" "ENSG00000127580" "WDR24" "A2IDB8; D3DU59; hsa:84219; Q96GC7; Q96S15; Q9H0B7" "Amino acids regulate mTORC1" "" "1" "0" "12.3" "13.1" "17.5" "20.8" "10.9" "12.4" "26.1" "15.0" "13.0" "46.4" "29.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A8MWD9" "Putative small nuclear ribonucleoprotein G-like protein 15 OS=Homo sapiens OX=9606 GN=SNRPGP15 PE=5 SV=2" "9" "1" "2" "1" "76" "8.5" "8.84" "249.39" "2.56" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "" "" "SNRPGP15" "A8MWD9" "" "" "0" "0" "101.9" "76.5" "110.4" "322.0" "166.8" "78.1" "167.4" "92.8" "118.8" "342.9" "220.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "2" "1" "2" "1" "445" "52.2" "6.04" "255.66" "2.55" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "75.1" "79.9" "114.6" "320.4" "147.1" "109.7" "173.6" "86.8" "114.6" "438.6" "392.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16850" "Lanosterol 14-alpha demethylase OS=Homo sapiens OX=9606 GN=CYP51A1 PE=1 SV=3" "3" "1" "2" "1" "503" "56.8" "8.53" "308.55" "2.55" "1" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96RK4" "Bardet-Biedl syndrome 4 protein OS=Homo sapiens OX=9606 GN=BBS4 PE=1 SV=2" "1" "1" "2" "1" "519" "58.2" "7.31" "310.97" "2.55" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13181, Pf13414" "585" "ENSG00000140463" "BBS4" "B4E178; hsa:585; Q53DZ5; Q8NHU9; Q96H45; Q96RK4" "BBSome-mediated cargo-targeting to cilium" "Prader-Willi and Angelman syndrome; Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "7" "0" "20.0" "22.2" "31.1" "74.5" "42.3" "34.1" "53.3" "36.1" "107.5" "744.9" "750.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969N2" "GPI transamidase component PIG-T OS=Homo sapiens OX=9606 GN=PIGT PE=1 SV=1" "2" "1" "1" "1" "578" "65.7" "8.38" "" "2.55" "" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "" "Pf04113" "51604" "ENSG00000124155" "PIGT" "B2RND5; B7Z3N1; B7Z7I8; E1P622; G8JLF5; hsa:51604; Q2NL69; Q7Z3N7; Q969N2; Q9BQY7; Q9BQY8; Q9UJG6; Q9Y2Z5" "Attachment of GPI anchor to uPAR" "IL-18 signaling pathway" "2" "0" "2.8" "3.3" "7.2" "17.8" "9.0" "6.1" "8.8" "4.5" "2.9" "24.2" "35.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "3" "1" "2" "1" "329" "36.0" "7.02" "322.07" "2.55" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "10.1" "12.0" "11.8" "77.0" "24.6" "0.1" "7.8" "5.4" "4.4" "13.9" "14.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6SZW1" "NAD(+) hydrolase SARM1 OS=Homo sapiens OX=9606 GN=SARM1 PE=1 SV=1" "2" "1" "1" "1" "724" "79.3" "6.55" "" "2.55" "" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf07647, Pf13676" "23098" "ENSG00000004139" "SARM1" "hsa:23098; O60277; Q6SZW1; Q7LGG3; Q9NXY5" "" "" "0" "0" "33.7" "38.7" "48.3" "128.1" "63.6" "36.3" "72.6" "44.3" "47.5" "131.6" "119.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UHB6" "LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1" "1" "1" "2" "1" "759" "85.2" "6.84" "249.74" "2.55" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "51474" "ENSG00000050405" "LIMA1" "B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IYI6" "Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2" "2" "1" "2" "1" "725" "81.7" "5.49" "249.30" "2.54" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf08700, Pf16528" "149371" "ENSG00000116903" "EXOC8" "B3KU33; hsa:149371; Q5TE82; Q8IYI6" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "RalA downstream regulated genes; Ciliary landscape" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "1" "1" "2" "1" "689" "74.3" "9.57" "258.66" "2.54" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859, Pf13847" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "2" "0" "56.6" "62.5" "79.2" "291.6" "120.2" "66.8" "122.1" "75.8" "75.3" "209.3" "150.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14191" "Werner syndrome ATP-dependent helicase OS=Homo sapiens OX=9606 GN=WRN PE=1 SV=2" "2" "2" "3" "2" "1432" "162.4" "6.34" "510.23" "2.54" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf01612, Pf09382, Pf14493, Pf16124" "7486" "ENSG00000165392" "WRN" "A1KYY9; hsa:7486; Q14191" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Removal of the Flap Intermediate from the C-strand" "Non-homologous end joining; DNA repair pathways, full network; Progeria-associated lipodystrophy; Primary ovarian insufficiency" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96L93" "Kinesin-like protein KIF16B OS=Homo sapiens OX=9606 GN=KIF16B PE=1 SV=2" "1" "1" "2" "1" "1317" "151.9" "6.16" "261.29" "2.54" "1" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf00787" "55614" "ENSG00000089177" "KIF16B" "A6NKJ9; A7E2A8; B1AKG3; B1AKT7; C9JDN5; C9JI52; C9JSM8; C9JWJ7; hsa:55614; Q2TBF5; Q5HYC0; Q5HYK1; Q5JWW3; Q5TFK5; Q86VL9; Q86YS5; Q8IYU0; Q96L93; Q9BQJ8; Q9BQM0; Q9BQM1; Q9BQM5; Q9H5U0; Q9HCI2; Q9NXN9" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "" "2" "0" "6.2" "3.0" "9.8" "20.9" "10.6" "8.2" "10.6" "5.7" "5.3" "49.6" "65.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "4" "1" "1" "1" "537" "60.1" "5.85" "" "2.54" "" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "High" "n/a" "n/a" "High" "High" "n/a" "1" "" "False" "IsMasterProtein" "Q9UPY3" "Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3" "1" "1" "2" "1" "1922" "218.5" "5.68" "263.20" "2.54" "1" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00271, Pf00636, Pf02170, Pf03368, Pf04851" "23405" "ENSG00000100697" "DICER1" "A7E2D3; B3KRG4; E0AD28; hsa:23405; O95943; Q9UPY3; Q9UQ02" "MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Hypoxia-mediated EMT and stemness; mRNA processing; Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P02042" "Hemoglobin subunit delta OS=Homo sapiens OX=9606 GN=HBD PE=1 SV=2" "7" "1" "1" "1" "147" "16.0" "8.05" "" "2.53" "" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "3045" "ENSG00000223609" "HBD" "hsa:3045; P02042; Q3Y5H3; Q8WXT7" "Factors involved in megakaryocyte development and platelet production" "VEGFA-VEGFR2 signaling" "2" "0" "43.0" "37.4" "58.9" "201.5" "106.8" "62.3" "92.9" "305.8" "78.2" "155.8" "132.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "6" "1" "2" "1" "140" "15.0" "6.99" "373.79" "2.53" "1" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways" "3" "0" "49.8" "42.3" "58.8" "275.3" "100.1" "20.5" "100.8" "44.6" "44.1" "141.2" "88.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "2" "1" "2" "1" "638" "69.8" "8.95" "303.91" "2.53" "1" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane" "" "2" "0" "9.7" "6.9" "8.8" "27.8" "13.7" "8.4" "17.4" "13.3" "8.3" "42.6" "42.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2I6" "Ninein-like protein OS=Homo sapiens OX=9606 GN=NINL PE=1 SV=2" "1" "1" "1" "1" "1382" "156.2" "5.06" "" "2.52" "" "1" "cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13499" "22981" "ENSG00000101004" "NINL" "A6NJN0; B3V9H6; B7Z1V8; hsa:22981; Q5JYP0; Q8NE38; Q9NQE3; Q9Y2I6" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Ciliary landscape" "8" "0" "98.8" "67.9" "72.4" "114.6" "80.0" "77.6" "159.2" "98.2" "165.6" "359.6" "334.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13888" "General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1" "2" "1" "2" "1" "395" "44.4" "6.76" "300.24" "2.52" "1" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus" "other molecular function" "Pf04056, Pf07975" "2966" "ENSG00000145736; ENSG00000275045; ENSG00000276910" "GTF2H2" "hsa:2966; Q13888; Q15570; Q15571; Q9BS41" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "33" "0" "0.0" "0.0" "0.0" "0.0" "0.0" "0.0" "0.0" "10.9" "1.3" "27.6" "89.7" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "6" "1" "2" "1" "163" "17.6" "10.30" "295.10" "2.52" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "65.9" "51.6" "85.8" "176.2" "103.9" "69.8" "125.8" "50.4" "67.7" "132.4" "87.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14653" "Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2" "5" "1" "2" "1" "212" "24.8" "8.06" "252.77" "2.51" "1" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf12352" "9570" "ENSG00000108433" "GOSR2" "D3DXJ5; D3DXJ6; hsa:9570; O14653; Q8N4B8; Q96DA5; Q9BZZ4" "COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "1" "1" "2" "1" "1447" "164.6" "8.47" "251.32" "2.51" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome" "5" "0" "7.7" "9.1" "7.0" "17.0" "13.4" "3.8" "10.4" "6.0" "6.2" "31.8" "30.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q93096" "Protein tyrosine phosphatase type IVA 1 OS=Homo sapiens OX=9606 GN=PTP4A1 PE=1 SV=2" "11" "2" "3" "2" "173" "19.8" "8.97" "735.04" "2.51" "2" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00782" "7803" "ENSG00000112245" "PTP4A1" "B2R6C8; hsa:7803; O00648; Q49A54; Q93096" "" "" "0" "0" "123.0" "87.2" "122.4" "312.4" "146.8" "95.1" "176.0" "89.0" "111.5" "330.0" "254.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "1" "1" "2" "1" "1085" "122.3" "6.47" "248.44" "2.51" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRK6" "ATP-binding cassette sub-family B member 10, mitochondrial OS=Homo sapiens OX=9606 GN=ABCB10 PE=1 SV=2" "1" "1" "2" "1" "738" "79.1" "9.85" "304.23" "2.51" "1" "1" "other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00005, Pf00664" "23456" "ENSG00000135776" "ABCB10" "hsa:23456; Q13040; Q6P1Q8; Q9H3V0; Q9NRK6" "Mitochondrial ABC transporters" "" "1" "0" "7.3" "8.0" "13.5" "79.4" "24.7" "8.9" "10.8" "8.9" "9.6" "23.7" "41.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "1" "1" "2" "1" "1972" "213.4" "4.70" "325.07" "2.51" "1" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); SUMOylation of transcription factors" "ATM signaling pathway; ATM signaling in development and disease" "7" "0" "111.6" "100.0" "124.5" "286.2" "167.8" "112.8" "174.4" "97.8" "105.5" "226.3" "109.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "4" "1" "2" "1" "352" "40.2" "5.47" "331.72" "2.51" "1" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q93074" "Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4" "1" "1" "2" "1" "2177" "242.9" "7.05" "268.55" "2.50" "1" "1" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09497, Pf12144, Pf12145" "9968" "ENSG00000184634" "MED12" "hsa:9968; O15410; O75557; Q93074; Q9UHV6; Q9UND7" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway" "" "3" "0" "10.4" "14.0" "14.9" "39.2" "28.4" "14.3" "26.9" "17.5" "20.0" "74.6" "54.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "2" "1" "2" "1" "562" "62.6" "8.21" "316.80" "2.50" "1" "1" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "3" "1" "2" "1" "394" "44.4" "5.40" "267.21" "2.50" "1" "1" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "" "2" "0" "16.4" "19.2" "20.9" "55.6" "31.9" "18.4" "34.1" "23.1" "20.1" "34.0" "19.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P82912" "28S ribosomal protein S11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "15" "2" "3" "2" "194" "20.6" "10.81" "958.01" "2.50" "2" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "19.9" "14.0" "20.3" "108.7" "39.7" "23.6" "40.8" "17.9" "28.1" "68.1" "48.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "8" "2" "3" "2" "303" "34.8" "5.87" "750.78" "2.50" "2" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; hsa:10273; O60526; Q969U2; Q9HBT1; Q9UNE7" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Regulation of TNFR1 signaling; Downregulation of TGF-beta receptor signaling" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway" "10" "0" "26.9" "26.3" "51.1" "209.3" "72.1" "33.9" "98.7" "53.2" "55.3" "180.9" "108.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TEM1" "Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3" "1" "1" "2" "1" "1887" "205.0" "6.81" "321.11" "2.50" "1" "1" "transport" "other membranes;ER/Golgi;nucleus" "" "Pf02368" "23225" "ENSG00000132182" "NUP210" "A6NN56; hsa:23225; O94980; Q6NXG6; Q8NBJ1; Q8TEM1; Q9H6C8; Q9UFP3" "Vpr-mediated nuclear import of PICs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; Regulation of HSF1-mediated heat shock response; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; HCMV Late Events; SUMOylation of RNA binding proteins; HCMV Early Events; Transcriptional regulation by small RNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "" "28" "0" "9.8" "8.8" "10.5" "41.3" "19.2" "11.4" "13.9" "14.1" "10.8" "25.1" "15.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3C4" "EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1" "4" "1" "2" "1" "175" "19.6" "6.79" "308.84" "2.49" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08617" "51002" "ENSG00000144034" "TPRKB" "D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "84.7" "78.0" "127.8" "410.4" "157.9" "62.0" "230.6" "89.8" "76.3" "375.8" "212.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "2" "1" "1" "1" "725" "83.6" "7.05" "" "2.49" "" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "1" "1" "2" "1" "726" "80.6" "8.78" "356.47" "2.49" "1" "1" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "17" "0" "144.1" "108.0" "122.3" "245.8" "149.1" "118.8" "197.6" "84.1" "252.0" "587.9" "409.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P48507" "Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1" "5" "1" "2" "1" "274" "30.7" "6.02" "261.07" "2.49" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00248" "2730" "ENSG00000023909" "GCLM" "A8K334; D3DT45; hsa:2730; M5A959; P48507; Q6FHC1; Q9NPX9; Q9NU74" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino acid metabolism; Ferroptosis; NRF2-ARE regulation; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "n/a" "1" "" "False" "IsMasterProtein" "Q9HB19" "Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=2" "2" "1" "2" "1" "425" "47.2" "8.66" "256.20" "2.49" "1" "1" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00169" "59339" "" "PLEKHA2" "hsa:59339; Q9HB19" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "0.0" "3.3" "4.7" "9.2" "3.3" "3.5" "5.2" "7.4" "15.3" "55.9" "66.7" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95140" "Mitofusin-2 OS=Homo sapiens OX=9606 GN=MFN2 PE=1 SV=3" "1" "1" "2" "1" "757" "86.3" "6.98" "257.97" "2.49" "1" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00350, Pf04799" "9927" "ENSG00000116688" "MFN2" "A8K1B3; hsa:9927; O95140; O95572; Q5JXC3; Q5JXC4; Q9H131; Q9NSX8" "Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle" "Intracellular trafficking proteins involved in CMT neuropathy" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y680" "Peptidyl-prolyl cis-trans isomerase FKBP7 OS=Homo sapiens OX=9606 GN=FKBP7 PE=1 SV=2" "5" "1" "1" "1" "222" "25.8" "6.32" "" "2.49" "" "1" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf00254, Pf13202" "51661" "ENSG00000079150" "FKBP7" "hsa:51661; Q4ZG70; Q6V3B2; Q86U65; Q96DA4; Q9Y680; Q9Y6B0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P49770" "Translation initiation factor eIF-2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "5" "1" "2" "1" "351" "39.0" "6.16" "317.48" "2.49" "1" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Recycling of eIF2:GDP" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome causing genes; Primary ovarian insufficiency" "5" "0" "18.1" "16.9" "26.7" "71.6" "38.4" "22.2" "42.7" "27.0" "31.4" "90.1" "79.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "5" "2" "2" "2" "457" "49.8" "8.41" "285.18" "2.49" "1" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "RET signaling" "Ebstein-Barr virus LMP1 signaling; GDNF signaling" "3" "0" "36.6" "29.9" "48.2" "103.2" "62.3" "41.0" "67.0" "26.4" "45.7" "124.8" "96.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "5" "2" "3" "2" "220" "25.4" "10.07" "644.14" "2.48" "2" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "tRNA processing in the nucleus" "" "1" "0" "44.5" "54.0" "46.5" "149.6" "65.9" "44.8" "81.3" "64.3" "48.5" "132.6" "108.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62328" "Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2" "16" "1" "2" "1" "44" "5.1" "5.06" "310.24" "2.48" "1" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01290" "7114" "ENSG00000205542" "TMSB4X" "hsa:7114; P01253; P01254; P62328; Q546P5; Q63576; Q9UE55" "Platelet degranulation" "Genes targeted by miRNAs in adipocytes; VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Regulation of actin cytoskeleton" "5" "0" "197.5" "199.9" "342.1" "2331.0" "607.9" "68.7" "146.1" "219.1" "146.1" "310.7" "267.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "3" "1" "2" "1" "420" "46.3" "7.21" "308.99" "2.48" "1" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "Synthesis of GDP-mannose" "N-glycan biosynthesis" "2" "0" "11.0" "12.1" "16.6" "111.9" "31.5" "15.4" "26.1" "23.6" "16.4" "49.2" "45.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00507" "Probable ubiquitin carboxyl-terminal hydrolase FAF-Y OS=Homo sapiens OX=9606 GN=USP9Y PE=2 SV=2" "0" "1" "1" "1" "2555" "290.9" "5.86" "" "2.48" "" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8287" "ENSG00000114374" "USP9Y" "hsa:8287; O00507; O14601" "" "" "0" "0" "119.2" "94.3" "112.6" "249.2" "127.9" "77.5" "154.1" "119.2" "306.3" "1416.3" "1103.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75446" "Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1" "5" "1" "1" "1" "220" "23.3" "9.17" "" "2.48" "" "1" "RNA metabolism OR transcription;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "8819" "ENSG00000164105" "SAP30" "D3DP38; hsa:8819; O75446" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "Retinoblastoma gene in cancer; Notch signaling pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P82914" "28S ribosomal protein S15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" "3" "1" "2" "1" "257" "29.8" "10.48" "310.49" "2.48" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00312" "64960" "ENSG00000116898" "MRPS15" "B2RD82; hsa:64960; P82914; Q9H2K1" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "153.5" "142.4" "157.1" "589.4" "239.8" "140.9" "265.2" "168.6" "165.9" "500.0" "421.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H3R2" "Mucin-13 OS=Homo sapiens OX=9606 GN=MUC13 PE=1 SV=3" "3" "1" "1" "1" "512" "54.6" "5.07" "" "2.48" "" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01390" "56667" "ENSG00000173702" "MUC13" "hsa:56667; Q6UWD9; Q9H3R2; Q9NXT5" "RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Dectin-2 family; Termination of O-glycan biosynthesis; Defective GALNT3 causes HFTC; Defective C1GALT1C1 causes TNPS; Defective GALNT12 causes CRCS1" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "4" "1" "2" "1" "226" "24.4" "6.10" "307.33" "2.47" "1" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "61" "0" "65.3" "82.1" "109.9" "922.7" "185.3" "3.6" "97.8" "102.9" "66.6" "319.4" "387.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "4" "1" "2" "1" "180" "20.3" "4.96" "296.12" "2.47" "1" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "45.8" "41.2" "71.2" "199.8" "86.7" "46.2" "109.7" "58.7" "67.7" "726.1" "965.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01780" "Exosome component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2" "1" "1" "2" "1" "885" "100.8" "8.46" "257.64" "2.46" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00570, Pf01612, Pf08066" "5394" "ENSG00000171824" "EXOSC10" "B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "11.9" "5.6" "10.5" "20.5" "14.5" "9.0" "12.2" "9.0" "5.0" "28.9" "21.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "3" "1" "2" "1" "349" "38.7" "5.78" "294.38" "2.46" "1" "1" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "6.4" "4.6" "5.6" "27.1" "8.1" "1.3" "10.4" "4.4" "6.0" "20.2" "22.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "2" "1" "2" "1" "633" "68.0" "9.94" "299.49" "2.46" "1" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Regulation of TP53 Activity through Acetylation" "" "6" "0" "5.0" "7.0" "8.5" "29.2" "15.9" "6.8" "12.7" "8.2" "7.1" "17.2" "12.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95164" "Ubiquitin-like protein 3 OS=Homo sapiens OX=9606 GN=UBL3 PE=1 SV=1" "12" "1" "1" "1" "117" "13.1" "6.77" "" "2.46" "" "1" "" "plasma membrane;other membranes" "" "Pf13881" "5412" "ENSG00000122042" "UBL3" "B2R4J1; hsa:5412; O95164; Q5RL72; Q5VZS0; Q6FIG8; Q96SG7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "4" "1" "2" "1" "334" "37.5" "7.36" "432.56" "2.46" "1" "1" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Ub-specific processing proteases; Methylation" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Methylation pathways" "7" "0" "75.7" "90.6" "115.2" "492.7" "169.3" "53.4" "161.3" "106.5" "85.0" "197.6" "145.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P09001" "39S ribosomal protein L3, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "2" "1" "2" "1" "348" "38.6" "9.48" "287.72" "2.45" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "60.4" "70.1" "97.3" "347.9" "124.1" "65.7" "141.2" "83.1" "79.5" "347.8" "312.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "1" "1" "2" "1" "1105" "122.8" "5.76" "244.50" "2.45" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "32.8" "30.4" "39.5" "129.6" "55.4" "37.0" "65.6" "35.5" "40.4" "114.8" "83.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96D09" "G-protein coupled receptor-associated sorting protein 2 OS=Homo sapiens OX=9606 GN=GPRASP2 PE=1 SV=1" "1" "1" "1" "1" "838" "93.7" "5.01" "" "2.45" "" "1" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04826" "100528062; 114928" "ENSG00000158301" "GPRASP2" "D3DXA0; hsa:100528062; hsa:114928; Q8NAB4; Q96D09" "" "Alstrom syndrome" "1" "0" "41.8" "34.8" "57.5" "151.0" "76.5" "51.7" "82.5" "51.0" "79.2" "242.0" "136.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "2" "1" "2" "1" "419" "48.2" "6.15" "276.11" "2.45" "1" "1" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "9" "0" "19.1" "35.3" "43.7" "308.7" "86.5" "0.1" "21.4" "42.6" "21.9" "46.2" "66.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "15" "1" "2" "1" "86" "9.7" "4.67" "236.55" "2.45" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "snRNP Assembly; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "104.7" "68.0" "113.0" "226.8" "133.0" "88.5" "135.2" "49.9" "81.3" "131.4" "94.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "8" "1" "1" "1" "118" "13.7" "8.79" "" "2.44" "" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Osteoclast signaling; Proximal tubule transport" "7" "0" "21.3" "24.6" "40.7" "130.8" "69.2" "36.9" "65.6" "34.6" "48.4" "112.1" "104.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96QR8" "Transcriptional activator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "3" "1" "2" "1" "312" "33.2" "5.43" "248.84" "2.44" "1" "1" "RNA metabolism OR transcription;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "82.7" "72.0" "108.1" "405.6" "152.2" "105.5" "207.2" "95.9" "125.9" "324.8" "217.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "1" "1" "2" "1" "1411" "162.4" "5.68" "245.43" "2.44" "1" "1" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "Toll Like Receptor 9 (TLR9) Cascade" "VEGFA-VEGFR2 signaling" "2" "0" "0.0" "5.6" "4.4" "39.7" "7.1" "3.6" "5.2" "7.8" "4.3" "30.4" "31.1" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969V3" "Nicalin OS=Homo sapiens OX=9606 GN=NCLN PE=1 SV=2" "2" "1" "2" "1" "563" "62.9" "6.89" "262.26" "2.44" "1" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity" "Pf04389" "56926" "ENSG00000125912" "NCLN" "D6W613; hsa:56926; O75252; Q6FI60; Q6ZMB7; Q8TAT7; Q969V3; Q96H48; Q96IS7; Q9BQH9; Q9BTX4; Q9NPP2" "" "" "0" "0" "14.4" "12.4" "17.1" "80.7" "30.2" "14.4" "33.1" "13.8" "14.2" "62.9" "76.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P08069" "Insulin-like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1" "1" "1" "1" "1" "1367" "154.7" "5.80" "" "2.44" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function" "Pf00757, Pf01030, Pf07714" "3480" "ENSG00000140443" "IGF1R" "B1B5Y2; hsa:3480; P08069; Q14CV2; Q9UCC0" "Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R" "MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus infection in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Pleural mesothelioma; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; TROP2 regulatory signaling; A network map of Macrophage-stimulating protein (MSP) signaling" "28" "0" "31.2" "19.6" "47.9" "80.8" "54.9" "50.1" "83.2" "10.3" "23.3" "49.1" "13.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y305" "Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2" "2" "1" "1" "1" "439" "49.9" "8.60" "" "2.43" "" "1" "other metabolic processes" "mitochondrion" "other molecular function" "" "23597" "ENSG00000123130" "ACOT9" "B3KNC9; B7ZM94; hsa:23597; Q9Y305" "Mitochondrial Fatty Acid Beta-Oxidation" "VEGFA-VEGFR2 signaling" "2" "0" "22.9" "18.9" "32.9" "83.4" "40.7" "24.2" "39.9" "24.5" "21.5" "61.9" "52.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TDW7" "Protocadherin Fat 3 OS=Homo sapiens OX=9606 GN=FAT3 PE=2 SV=3" "0" "1" "4" "1" "4557" "501.7" "4.87" "237.89" "2.42" "1" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028, Pf02210" "120114" "ENSG00000165323" "FAT3" "B5MDB0; hsa:120114; Q8TDW7; Q96AU6" "" "" "0" "0" "17.0" "20.8" "13.7" "32.9" "29.0" "17.9" "24.9" "66.6" "75.4" "474.9" "1212.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0" "1" "2" "1" "1944" "216.4" "6.30" "323.65" "2.42" "1" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf19521, Pf20518" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; Separation of Sister Chromatids; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle; 2q13 copy number variation syndrome" "20" "0" "48.9" "43.7" "57.4" "119.4" "63.8" "46.3" "76.6" "51.5" "57.7" "168.9" "173.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "9" "1" "2" "1" "122" "13.3" "8.46" "321.00" "2.42" "1" "1" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "51.9" "43.4" "58.9" "135.4" "66.1" "53.2" "112.3" "42.7" "50.8" "214.3" "189.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "2" "1" "2" "1" "722" "78.9" "6.38" "245.84" "2.42" "1" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZJ0" "Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4" "2" "1" "2" "1" "848" "100.4" "8.00" "260.80" "2.41" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf02184" "51340" "ENSG00000101343" "CRNKL1" "A8K9T4; hsa:51340; Q5JY64; Q8WYI5; Q9BZI9; Q9BZJ0; Q9BZJ1; Q9BZJ2; Q9GZW7; Q9H8F8; Q9NQH5; Q9NYD8" "mRNA Splicing - Major Pathway" "" "1" "0" "14.1" "15.6" "20.8" "55.6" "22.9" "19.3" "28.6" "15.6" "25.2" "60.5" "86.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "6" "1" "2" "1" "221" "25.5" "8.65" "266.15" "2.41" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "6" "1" "2" "1" "127" "15.0" "4.12" "233.15" "2.41" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "157.3" "133.1" "194.9" "447.2" "216.4" "136.4" "241.0" "153.3" "193.3" "355.3" "266.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "4" "1" "2" "1" "199" "21.5" "5.24" "240.65" "2.41" "1" "1" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "56.2" "65.7" "91.3" "287.1" "137.2" "63.0" "137.7" "87.9" "83.5" "272.8" "214.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14684" "Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3" "1" "1" "2" "1" "758" "84.4" "9.76" "291.38" "2.40" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05997" "23076" "ENSG00000160208" "RRP1B" "hsa:23076; Q14684; Q8TBZ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "1" "1" "2" "1" "1034" "117.1" "7.87" "328.23" "2.40" "1" "1" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "37.7" "33.9" "37.2" "72.0" "41.2" "36.1" "46.6" "21.8" "31.9" "55.5" "37.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "4" "1" "2" "1" "191" "20.9" "4.39" "287.77" "2.40" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "59.1" "50.8" "80.4" "377.9" "121.2" "29.4" "126.2" "60.3" "50.8" "194.2" "109.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q06481" "Amyloid-like protein 2 OS=Homo sapiens OX=9606 GN=APLP2 PE=1 SV=2" "2" "1" "2" "1" "763" "86.9" "4.79" "256.36" "2.40" "1" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00014, Pf02177, Pf10515, Pf12924, Pf12925" "334" "ENSG00000084234" "APLP2" "B3KXX9; H7BXI4; hsa:334; Q06481; Q13861; Q14594; Q14662; Q71U10; Q7M4L3; Q9BT36" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation" "Splicing factor NOVA regulated synaptic proteins" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "3" "1" "1" "1" "356" "38.1" "9.83" "" "2.40" "" "1" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "167.9" "89.9" "167.9" "251.1" "139.4" "112.0" "152.4" "102.0" "131.0" "280.8" "311.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKV5" "E3 ubiquitin-protein ligase AMFR OS=Homo sapiens OX=9606 GN=AMFR PE=1 SV=2" "2" "1" "1" "1" "643" "72.9" "6.39" "" "2.40" "" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02845, Pf13639, Pf18442" "267" "ENSG00000159461" "AMFR" "hsa:267; P26442; Q8IZ70; Q9UKV5" "ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Sterol regulatory element-binding proteins (SREBP) signaling" "3" "0" "13.2" "8.8" "11.9" "19.5" "15.1" "10.8" "13.8" "12.0" "35.6" "92.4" "115.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "3" "1" "2" "1" "282" "31.4" "7.02" "259.00" "2.40" "1" "1" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Glutathione conjugation" "Phase I biotransformations, non P450" "2" "0" "49.7" "51.5" "73.8" "363.4" "127.6" "44.0" "75.0" "71.5" "69.2" "151.7" "146.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "1" "1" "2" "1" "790" "91.8" "6.43" "246.04" "2.39" "1" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "19.4" "15.1" "20.8" "73.7" "33.9" "20.0" "34.9" "25.0" "25.6" "131.5" "94.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96A73" "Putative monooxygenase p33MONOX OS=Homo sapiens OX=9606 GN=KIAA1191 PE=1 SV=1" "4" "1" "3" "1" "305" "33.2" "9.39" "518.21" "2.39" "1" "1" "" "other cell component" "other molecular function" "Pf15302" "57179" "ENSG00000122203" "KIAA1191" "B2RD69; B8K1S6; hsa:57179; Q6IA24; Q8NDU3; Q96A73; Q9BRE5; Q9H7D5; Q9ULM9" "" "" "0" "0" "94.8" "77.7" "94.4" "166.2" "108.8" "97.8" "153.4" "97.3" "137.5" "224.5" "160.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15573" "TATA box-binding protein-associated factor RNA polymerase I subunit A OS=Homo sapiens OX=9606 GN=TAF1A PE=1 SV=1" "2" "1" "1" "1" "450" "52.6" "9.10" "" "2.38" "" "1" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus" "nucleic acid binding activity" "Pf14929" "9015" "ENSG00000143498" "TAF1A" "B2RDZ8; D3DTB7; hsa:9015; Q15573; Q9NWA1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; SIRT1 negatively regulates rRNA expression" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=1" "3" "2" "3" "2" "796" "88.8" "5.19" "883.69" "2.38" "2" "1" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "95.6" "86.0" "133.2" "613.9" "214.2" "112.7" "198.2" "124.6" "137.2" "419.6" "281.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13308" "Inactive tyrosine-protein kinase 7 OS=Homo sapiens OX=9606 GN=PTK7 PE=1 SV=2" "1" "1" "2" "1" "1070" "118.3" "7.09" "335.00" "2.37" "1" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf07679, Pf07714, Pf13927" "5754" "ENSG00000112655" "PTK7" "A8K974; B7Z477; E9PFZ5; hsa:5754; Q13308; Q13417; Q5T650; Q6IQ54; Q8NFA5; Q8NFA6; Q8NFA7; Q8NFA8" "" "" "0" "0" "7.7" "7.6" "11.7" "48.6" "14.9" "4.1" "11.7" "6.8" "8.5" "26.3" "21.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z7K0" "COX assembly mitochondrial protein homolog OS=Homo sapiens OX=9606 GN=CMC1 PE=1 SV=1" "8" "1" "2" "1" "106" "12.5" "8.63" "267.78" "2.36" "1" "1" "" "mitochondrion" "other molecular function" "Pf08583" "152100" "ENSG00000187118" "CMC1" "hsa:152100; Q68DJ7; Q7Z7K0" "" "Mitochondrial complex IV assembly" "1" "0" "76.0" "62.3" "94.6" "258.6" "124.7" "72.3" "147.3" "80.9" "97.8" "312.5" "213.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UL33" "Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1" "10" "1" "1" "1" "140" "16.1" "6.77" "" "2.36" "" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04628" "51693" "ENSG00000167515" "TRAPPC2L" "B2R4M9; hsa:51693; Q6ZTA7; Q9NZZ4; Q9UL33" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "31.6" "14.5" "28.2" "36.2" "36.2" "29.1" "38.5" "30.9" "26.3" "69.5" "50.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "1" "1" "2" "1" "1151" "131.6" "4.98" "276.86" "2.36" "1" "1" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "5" "1" "2" "1" "233" "26.0" "4.79" "289.22" "2.36" "1" "1" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95298" "NADH dehydrogenase [ubiquinone] 1 subunit C2 OS=Homo sapiens OX=9606 GN=NDUFC2 PE=1 SV=1" "6" "1" "1" "1" "119" "14.2" "8.98" "" "2.36" "" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity" "Pf06374" "4718" "ENSG00000151366" "NDUFC2" "E9PNU8; E9PRB2; hsa:4718; O95298; Q549M5; Q6FIH8; Q9UBJ9" "Neutrophil degranulation; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "87.7" "81.1" "108.7" "391.6" "151.7" "90.4" "128.8" "102.5" "100.0" "267.5" "244.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q53FA7" "Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2" "2" "1" "2" "1" "332" "35.5" "7.17" "287.69" "2.36" "1" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00107, Pf08240" "9540" "ENSG00000115129" "TP53I3" "D6W533; hsa:9540; O14679; O14685; Q38G78; Q53FA7; Q6JLE7; Q9BWB8" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "p53 transcriptional gene network; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "3" "0" "3.2" "0.0" "4.3" "7.9" "3.8" "6.9" "6.3" "10.7" "25.5" "79.8" "85.6" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRX2" "39S ribosomal protein L17, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "9" "2" "3" "2" "175" "20.0" "10.11" "517.95" "2.35" "2" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "101.0" "87.4" "137.5" "407.5" "188.2" "101.5" "208.9" "112.2" "122.7" "338.9" "295.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15006" "ER membrane protein complex subunit 2 OS=Homo sapiens OX=9606 GN=EMC2 PE=1 SV=1" "5" "1" "1" "1" "297" "34.8" "6.57" "" "2.35" "" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf14559" "9694" "ENSG00000104412" "EMC2" "hsa:9694; Q15006; Q8WUE1" "" "" "0" "0" "15.6" "12.3" "22.2" "39.0" "33.6" "20.3" "38.2" "17.1" "22.1" "70.0" "46.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96D71" "RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3" "1" "1" "2" "1" "796" "86.6" "5.69" "265.71" "2.35" "1" "1" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "85021" "ENSG00000135597" "REPS1" "B7ZBZ8; B7ZBZ9; B7ZC00; hsa:85021; J3KP76; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q96D71; Q9BXY9" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "9.3" "11.8" "20.3" "61.8" "39.5" "12.2" "14.9" "11.5" "14.0" "18.2" "8.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96A26" "Protein FAM162A OS=Homo sapiens OX=9606 GN=FAM162A PE=1 SV=2" "5" "1" "2" "1" "154" "17.3" "9.77" "285.14" "2.35" "1" "1" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "" "Pf06388" "26355" "ENSG00000114023" "FAM162A" "hsa:26355; Q96A26; Q9NRN6; Q9UJX8" "" "" "0" "0" "48.0" "50.6" "62.7" "248.6" "96.1" "60.1" "106.9" "67.0" "77.7" "150.4" "109.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "4" "2" "3" "2" "412" "45.7" "6.48" "504.12" "2.35" "2" "1" "stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "" "1" "0" "71.4" "68.9" "103.8" "296.9" "147.3" "82.3" "147.6" "90.1" "102.9" "386.7" "383.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UF33" "Ephrin type-A receptor 6 OS=Homo sapiens OX=9606 GN=EPHA6 PE=2 SV=3" "1" "1" "1" "1" "1036" "116.3" "6.98" "" "2.35" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00041, Pf00536, Pf01404, Pf07699, Pf07714, Pf14575" "285220" "ENSG00000080224" "EPHA6" "D6RAL5; hsa:285220; Q9UF33" "EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse" "" "3" "0" "183.4" "162.8" "204.8" "302.3" "253.1" "214.4" "233.2" "152.7" "193.5" "344.4" "235.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "6" "3" "4" "2" "432" "46.5" "6.39" "794.00" "2.35" "3" "1" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "4" "0" "28.5" "28.7" "30.2" "174.8" "53.7" "17.7" "32.6" "28.3" "21.1" "69.3" "55.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "B8ZZ34" "Protein shisa-8 OS=Homo sapiens OX=9606 GN=SHISA8 PE=3 SV=3" "2" "1" "2" "1" "397" "42.0" "10.55" "285.34" "2.34" "1" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf13908" "440829" "ENSG00000234965" "SHISA8" "A0A087WXQ4; B8ZZ34; hsa:440829" "" "" "0" "0" "28.5" "25.0" "35.2" "94.3" "39.7" "35.7" "50.1" "35.5" "55.7" "583.7" "525.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "5" "1" "2" "1" "211" "23.3" "8.91" "272.43" "2.34" "1" "1" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "hsa:84309; Q8NAI2; Q9BRJ7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9C0D4" "Zinc finger protein 518B OS=Homo sapiens OX=9606 GN=ZNF518B PE=1 SV=2" "1" "1" "1" "1" "1074" "119.5" "9.45" "" "2.34" "" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "85460" "ENSG00000178163" "ZNF518B" "hsa:85460; Q96LN8; Q9C0D4" "" "" "0" "0" "12.6" "13.6" "15.0" "36.6" "19.2" "9.7" "23.3" "13.1" "15.7" "36.3" "25.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14690" "Protein RRP5 homolog OS=Homo sapiens OX=9606 GN=PDCD11 PE=1 SV=3" "1" "1" "2" "1" "1871" "208.6" "8.87" "300.69" "2.33" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00575, Pf05843" "22984" "ENSG00000148843" "PDCD11" "hsa:22984; Q14690; Q2TA92; Q5W093; Q6P2J3; Q86VQ8; Q9H4P1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "n/a" "High" "n/a" "1" "" "False" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "6" "1" "1" "1" "156" "17.4" "4.93" "" "2.33" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; hsa:4706; O14561; Q9UNV1" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "41.9" "46.1" "84.3" "353.9" "113.7" "38.8" "123.7" "69.9" "99.8" "488.9" "363.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "3" "1" "1" "1" "199" "22.1" "8.10" "" "2.33" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "93.6" "51.1" "113.1" "135.6" "131.0" "89.5" "193.8" "93.2" "219.3" "758.7" "954.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "1" "1" "1" "1" "534" "60.2" "5.40" "" "2.33" "" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Neddylation" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "4" "0" "6.1" "11.4" "12.4" "95.8" "21.8" "3.2" "6.8" "9.6" "6.5" "16.7" "16.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "4" "1" "2" "1" "163" "17.7" "5.19" "273.05" "2.33" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "3" "0" "22.2" "23.8" "31.5" "134.4" "53.9" "25.3" "48.4" "27.4" "38.1" "135.8" "120.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P1L8" "39S ribosomal protein L14, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" "6" "1" "1" "1" "145" "15.9" "10.24" "" "2.32" "" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00238" "64928" "ENSG00000180992" "MRPL14" "B2R575; hsa:64928; Q6P1L8; Q96Q72" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "21.0" "15.3" "25.4" "50.2" "26.6" "21.7" "25.6" "24.0" "20.4" "52.0" "58.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "2" "1" "2" "1" "572" "61.8" "7.09" "355.17" "2.32" "1" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "CRMPs in Sema3A signaling" "" "1" "0" "10.8" "9.4" "8.9" "50.8" "20.3" "8.6" "10.3" "12.4" "4.5" "14.2" "16.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96SU4" "Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2" "1" "1" "1" "1" "736" "83.1" "6.18" "" "2.32" "" "1" "other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114883" "ENSG00000117859" "OSBPL9" "B1AKJ8; B3KPQ4; D3DQ31; hsa:114883; Q5TFC0; Q6IA67; Q86YQ3; Q8NB17; Q8TAS8; Q96SK4; Q96SU4; Q9H9X2" "Synthesis of bile acids and bile salts" "" "1" "0" "17.5" "15.5" "29.9" "52.6" "34.2" "13.6" "27.6" "21.7" "22.5" "48.5" "45.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14686" "Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3" "0" "1" "2" "1" "2063" "219.0" "9.36" "253.40" "2.32" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13820" "23054" "ENSG00000198646" "NCOA6" "A6NLF1; B2RMN5; E1P5P7; hsa:23054; Q14686; Q9NTZ9; Q9UH74; Q9UK86" "Heme signaling; Cytoprotection by HMOX1; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Formation of WDR5-containing histone-modifying complexes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Kleefstra syndrome" "15" "0" "100.4" "96.7" "136.1" "502.3" "191.4" "79.8" "206.5" "114.9" "136.9" "621.9" "586.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "4" "1" "3" "1" "216" "24.5" "5.34" "523.37" "2.31" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "Unwinding of DNA" "" "1" "0" "101.8" "111.9" "153.0" "623.5" "237.4" "86.4" "108.3" "125.7" "93.2" "236.7" "267.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IYT3" "Coiled-coil domain-containing protein 170 OS=Homo sapiens OX=9606 GN=CCDC170 PE=1 SV=3" "3" "1" "1" "1" "715" "82.2" "6.64" "" "2.31" "" "1" "cell organization and biogenesis" "cytoskeleton;ER/Golgi" "cytoskeletal activity" "" "80129" "ENSG00000120262" "CCDC170" "hsa:80129; Q5VXB7; Q6P9E4; Q8IYT3; Q96KA9; Q9H5M3" "" "" "0" "0" "56.5" "48.3" "109.8" "342.3" "165.4" "82.6" "164.0" "35.0" "74.4" "196.2" "68.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96NW7" "Leucine-rich repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=LRRC7 PE=1 SV=1" "0" "1" "2" "1" "1537" "172.5" "6.81" "254.03" "2.31" "1" "1" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "" "Pf00595, Pf13855" "" "" "LRRC7" "Q5VXC2; Q5VXC3; Q68D07; Q86VE8; Q8WX20; Q96NW7; Q9P2I2" "Neutrophil degranulation; Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation" "" "7" "0" "36.6" "32.3" "53.0" "91.1" "50.9" "34.8" "92.7" "38.5" "47.6" "106.4" "49.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BYK8" "Helicase with zinc finger domain 2 OS=Homo sapiens OX=9606 GN=HELZ2 PE=1 SV=6" "0" "1" "2" "1" "2649" "294.5" "7.49" "271.02" "2.31" "1" "1" "RNA metabolism OR transcription;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf13086, Pf13087" "85441" "ENSG00000130589" "HELZ2" "hsa:85441; Q3C2G2; Q4VXQ1; Q8TEF3; Q96ND3; Q9BYK8; Q9C094" "Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; RORA activates gene expression" "" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IXM3" "39S ribosomal protein L41, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "5" "1" "1" "1" "137" "15.4" "9.57" "" "2.30" "" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "69.7" "77.8" "91.1" "294.8" "120.7" "69.8" "113.7" "96.2" "80.9" "226.8" "212.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "2" "1" "1" "1" "519" "56.1" "7.93" "" "2.30" "" "1" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "151.0" "152.0" "200.2" "842.2" "306.3" "114.9" "158.2" "128.0" "119.7" "211.5" "141.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZ01" "Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1" "3" "1" "1" "1" "308" "36.0" "9.45" "" "2.30" "" "1" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02544" "9524" "ENSG00000099797" "TECR" "B2RD55; hsa:9524; O75350; Q6IBB2; Q9BWK3; Q9NZ01; Q9Y6P0" "Synthesis of very long-chain fatty acyl-CoAs" "Fragile X syndrome" "2" "0" "110.1" "80.1" "112.1" "309.7" "168.1" "105.0" "174.6" "79.5" "105.6" "227.6" "154.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P00451" "Coagulation factor VIII OS=Homo sapiens OX=9606 GN=F8 PE=1 SV=1" "0" "1" "1" "1" "2351" "266.8" "7.36" "" "2.30" "" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00394, Pf00754, Pf07731, Pf07732" "2157" "ENSG00000185010" "F8" "hsa:2157; P00451; Q14286; Q5HY69" "Platelet degranulation ; COPII-mediated vesicle transport; Cargo concentration in the ER; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699; Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective factor IX causes thrombophilia; Defective F8 accelerates dissociation of the A2 domain; Defective F8 cleavage by thrombin; Defective F8 binding to von Willebrand factor; Defective F8 binding to the cell membrane; Defective cofactor function of FVIIIa variant; Defective F8 secretion; Defective F9 variant does not activate FX" "Blood clotting cascade; Complement and coagulation cascades" "17" "0" "41.6" "27.3" "48.8" "108.0" "65.5" "42.2" "79.2" "49.4" "127.8" "416.7" "325.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKG9" "Peroxisomal carnitine O-octanoyltransferase OS=Homo sapiens OX=9606 GN=CROT PE=1 SV=2" "2" "1" "1" "1" "612" "70.1" "7.08" "" "2.30" "" "1" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00755" "54677" "ENSG00000005469" "CROT" "A4D1D6; E7EQF2; hsa:54677; Q86V17; Q8IUW9; Q9UKG9; Q9Y6I2" "Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "1" "1" "2" "1" "906" "100.0" "6.29" "253.59" "2.30" "1" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P48201" "ATP synthase F(0) complex subunit C3, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MC3 PE=1 SV=1" "5" "1" "2" "1" "142" "14.7" "9.45" "307.31" "2.30" "1" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00137" "518" "ENSG00000154518" "ATP5MC3" "B2R4Z0; D3DPF0; hsa:518; P48201; Q4ZFX7" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "41.3" "39.8" "51.2" "127.1" "96.1" "70.1" "165.1" "115.5" "182.5" "287.3" "222.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96F63" "Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1" "3" "1" "1" "1" "343" "38.9" "4.59" "" "2.29" "" "1" "" "" "" "Pf09747" "90324" "ENSG00000142039" "CCDC97" "hsa:90324; Q658N6; Q96F63; Q96IF3" "" "" "0" "0" "66.9" "68.1" "85.0" "359.4" "142.3" "67.2" "106.2" "83.0" "66.5" "266.7" "294.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "3" "1" "2" "1" "309" "35.8" "6.80" "271.55" "2.29" "1" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "Vitamin B5 (pantothenate) metabolism" "" "1" "0" "37.9" "36.5" "40.2" "216.1" "76.3" "40.6" "54.9" "44.9" "37.0" "100.3" "75.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2KHR2" "DNA-binding protein RFX7 OS=Homo sapiens OX=9606 GN=RFX7 PE=1 SV=1" "1" "1" "1" "1" "1363" "146.8" "6.76" "" "2.29" "" "1" "RNA metabolism OR transcription;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257" "64864" "ENSG00000181827" "RFX7" "hsa:64864; Q2KHR2; Q6ZRR1; Q6ZTY6; Q8N3J0; Q9H7A9; Q9H956" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "1" "1" "2" "1" "882" "97.5" "6.21" "234.99" "2.29" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; p53 transcriptional gene network; DNA damage response" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P1U0" "DNA-directed RNA polymerase I subunit RPA12 OS=Homo sapiens OX=9606 GN=ZNRD1 PE=1 SV=1" "6" "1" "2" "1" "126" "13.9" "5.06" "274.64" "2.28" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096" "30834" "ENSG00000066379; ENSG00000206502; ENSG00000224859; ENSG00000233795; ENSG00000235176; ENSG00000235443; ENSG00000236808; ENSG00000236949" "POLR1H" "hsa:30834; Q9P1U0" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "7" "0" "41.1" "39.6" "52.4" "133.9" "67.8" "43.5" "88.2" "42.2" "117.5" "755.4" "491.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6NXR4" "TELO2-interacting protein 2 OS=Homo sapiens OX=9606 GN=TTI2 PE=1 SV=1" "1" "1" "2" "1" "508" "56.9" "7.09" "253.95" "2.28" "1" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10521" "80185" "ENSG00000129696" "TTI2" "D3DSV7; hsa:80185; Q6NXR4; Q96IM2; Q9H5N4" "" "" "0" "0" "8.1" "11.7" "19.7" "91.9" "26.6" "10.8" "45.0" "12.5" "14.0" "199.9" "149.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=2" "1" "1" "1" "1" "879" "100.6" "6.93" "" "2.27" "" "1" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "Purine salvage" "" "1" "0" "10.6" "15.0" "18.6" "75.6" "29.3" "17.4" "27.4" "25.8" "42.0" "208.4" "159.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86UZ6" "Zinc finger and BTB domain-containing protein 46 OS=Homo sapiens OX=9606 GN=ZBTB46 PE=1 SV=2" "2" "1" "1" "1" "589" "64.0" "5.87" "" "2.27" "" "1" "RNA metabolism OR transcription;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf13909" "140685" "ENSG00000130584" "ZBTB46" "E1P5K9; hsa:140685; Q5JWJ3; Q6GMV4; Q86UZ6; Q9BQK3; Q9H3Z8; Q9H3Z9" "" "" "0" "0" "78.3" "48.3" "121.6" "465.7" "186.8" "54.4" "145.5" "31.2" "194.6" "664.0" "280.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "2" "1" "2" "1" "1087" "123.8" "6.32" "356.65" "2.27" "1" "1" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "1" "" "False" "IsMasterProtein" "Q9NS40" "Potassium voltage-gated channel subfamily H member 7 OS=Homo sapiens OX=9606 GN=KCNH7 PE=2 SV=2" "1" "1" "1" "1" "1196" "134.9" "7.65" "" "2.27" "" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00027, Pf00520, Pf13426" "90134" "ENSG00000184611" "KCNH7" "hsa:90134; Q53QU4; Q53TB7; Q53TP9; Q8IV15; Q9NS40" "Voltage gated Potassium channels" "" "1" "0" "163.3" "259.1" "96.3" "155.8" "97.6" "87.9" "133.5" "400.2" "137.4" "628.5" "865.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78556" "C-C motif chemokine 20 OS=Homo sapiens OX=9606 GN=CCL20 PE=1 SV=1" "14" "1" "1" "1" "96" "10.8" "8.94" "" "2.26" "" "1" "cell-cell signaling;stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf00048" "6364" "ENSG00000115009" "CCL20" "hsa:6364; P78556; Q53S51; Q99664" "G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling" "Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Chemokine signaling pathway; IL-18 signaling pathway; Overview of proinflammatory and profibrotic mediators; Immune infiltration in pancreatic cancer; IL-26 signaling pathways" "11" "0" "76.3" "77.3" "156.0" "597.1" "251.9" "99.6" "227.6" "82.8" "133.9" "306.0" "152.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O96033" "Molybdopterin synthase sulfur carrier subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1" "13" "1" "1" "1" "88" "9.7" "4.72" "" "2.26" "" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02597" "4338" "ENSG00000164172" "MOCS2" "O96033" "Molybdenum cofactor biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "8" "1" "2" "1" "142" "15.6" "9.13" "351.64" "2.26" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "" "Complement system" "1" "0" "53.5" "46.8" "71.2" "188.8" "111.4" "45.4" "71.7" "60.7" "68.3" "153.6" "156.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "2" "1" "1" "1" "522" "58.7" "6.33" "" "2.26" "" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "2.8" "3.1" "5.0" "75.4" "13.3" "0.0" "0.0" "3.9" "4.5" "3.3" "11.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BYC9" "39S ribosomal protein L20, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "7" "1" "2" "1" "149" "17.4" "10.86" "239.97" "2.26" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "1p36 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q96MN5" "Transcription elongation factor A N-terminal and central domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TCEANC2 PE=1 SV=1" "5" "1" "2" "1" "208" "24.1" "10.05" "274.36" "2.26" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08711" "127428" "ENSG00000116205" "TCEANC2" "hsa:127428; Q5T702; Q8N8N2; Q96MN5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "4" "2" "2" "1" "385" "42.0" "9.69" "233.06" "2.25" "1" "1" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "52.1" "47.4" "61.7" "132.8" "87.2" "52.2" "107.2" "44.5" "67.6" "134.2" "72.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "1" "1" "2" "1" "771" "87.9" "7.87" "264.60" "2.25" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "9" "4" "4" "4" "334" "36.4" "7.36" "877.00" "2.25" "3" "1" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Gluconeogenesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis" "8" "0" "235.1" "215.2" "355.8" "1978.2" "611.8" "97.1" "201.3" "250.7" "205.0" "425.0" "486.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O94906" "Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1" "1" "1" "1" "1" "941" "106.9" "8.25" "" "2.25" "" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06424, Pf13181" "24148" "ENSG00000101161" "PRPF6" "B2RAR5; B3KMC6; hsa:24148; O94906; O95109; Q5VXS5; Q9H3Z1; Q9H4T9; Q9H4U8; Q9NTE6" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "2" "1" "1" "1" "419" "47.2" "8.94" "" "2.25" "" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "43.6" "43.3" "50.7" "126.0" "67.8" "62.3" "78.3" "58.7" "113.1" "414.8" "316.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99965" "Disintegrin and metalloproteinase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ADAM2 PE=2 SV=2" "2" "1" "1" "1" "735" "82.4" "6.15" "" "2.25" "" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00200, Pf01421, Pf01562, Pf08516" "2515" "ENSG00000104755; ENSG00000276286" "ADAM2" "hsa:2515; P78326; Q99965; Q9UQQ8" "Interaction With Cumulus Cells And The Zona Pellucida" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "2" "1" "1" "1" "729" "79.5" "5.22" "" "2.25" "" "1" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00071" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "13.2" "6.3" "24.8" "31.2" "34.3" "16.6" "30.0" "19.8" "14.3" "70.7" "25.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "3" "2" "4" "2" "772" "87.6" "8.41" "1060.82" "2.25" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "" "miRNA regulation of DNA damage response; DNA damage response" "2" "0" "11.8" "7.6" "8.0" "24.3" "12.6" "8.7" "16.5" "8.3" "12.7" "45.9" "35.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "1" "1" "2" "1" "913" "103.9" "7.37" "265.44" "2.24" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H2L5" "Ras association domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RASSF4 PE=1 SV=2" "2" "1" "1" "1" "321" "36.7" "7.75" "" "2.24" "" "1" "cell cycle OR cell proliferation;signal transduction" "" "" "Pf00788, Pf16517" "83937" "ENSG00000107551" "RASSF4" "hsa:83937; Q86WH5; Q86WH6; Q86WH7; Q8N5A9; Q8TCK6; Q9H2L5" "" "Pleural mesothelioma" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60524" "Nuclear export mediator factor NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "1" "1" "1" "1" "1076" "122.9" "6.35" "" "2.24" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "128.2" "124.6" "77.9" "168.3" "96.0" "45.5" "99.3" "53.6" "61.8" "199.1" "241.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12788" "Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2" "2" "1" "2" "1" "808" "89.0" "6.90" "283.87" "2.24" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf08625" "10607" "ENSG00000183751" "TBL3" "hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "7.0" "8.1" "10.1" "13.4" "12.7" "14.5" "27.6" "16.3" "16.1" "38.4" "47.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z494" "Nephrocystin-3 OS=Homo sapiens OX=9606 GN=NPHP3 PE=1 SV=1" "1" "1" "1" "1" "1330" "150.8" "6.76" "" "2.24" "" "1" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "" "Pf13424" "27031" "ENSG00000113971" "NPHP3" "hsa:27031; Q5JPE3; Q5JPE6; Q68D99; Q6NVH3; Q7Z492; Q7Z493; Q7Z494; Q8N9R2; Q8NCM5; Q96N70; Q96NK2" "Trafficking of myristoylated proteins to the cilium" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "n/a" "n/a" "High" "n/a" "n/a" "High" "n/a" "1" "" "False" "IsMasterProtein" "P11233" "Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1" "3" "1" "2" "1" "206" "23.6" "7.11" "248.31" "2.24" "1" "1" "cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00071" "5898" "ENSG00000006451" "RALA" "A4D1W3; hsa:5898; P11233" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; p38MAPK events" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "8" "0" "91.0" "89.3" "134.6" "364.4" "174.0" "99.7" "190.6" "139.7" "162.1" "473.0" "447.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WXE9" "Stonin-2 OS=Homo sapiens OX=9606 GN=STON2 PE=1 SV=1" "1" "1" "2" "1" "905" "101.1" "5.39" "316.40" "2.24" "1" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00928, Pf12016" "85439" "ENSG00000140022" "STON2" "G3V2T7; hsa:85439; Q17R24; Q59H11; Q6NT47; Q8WXE9; Q96RI7; Q96RU6" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "1" "1" "2" "1" "726" "79.4" "5.55" "271.73" "2.23" "1" "1" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "Platelet degranulation" "" "1" "0" "27.6" "37.1" "49.7" "287.7" "81.9" "22.3" "32.9" "41.1" "26.8" "87.1" "81.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IUH3" "RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1" "1" "1" "1" "1" "476" "53.5" "7.17" "" "2.23" "" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "129831" "ENSG00000155636" "RBM45" "hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9" "" "" "0" "0" "40.1" "37.4" "44.2" "111.1" "55.2" "39.6" "82.9" "48.9" "35.2" "123.2" "98.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "5" "1" "1" "1" "264" "29.6" "6.15" "" "2.23" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "Ciliary landscape" "5" "0" "0.0" "5.0" "5.0" "10.1" "8.3" "6.4" "10.5" "11.3" "14.7" "119.3" "150.6" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P38935" "DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3" "1" "1" "2" "1" "993" "109.1" "8.97" "232.47" "2.23" "1" "1" "cell organization and biogenesis;RNA metabolism OR transcription" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01424, Pf01428, Pf13086, Pf13087" "3508" "ENSG00000132740" "IGHMBP2" "A0PJD2; hsa:3508; P38935; Q00443; Q14177" "" "" "0" "0" "31.7" "26.0" "35.4" "96.8" "48.5" "26.6" "63.3" "41.6" "52.3" "211.5" "245.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NA03" "Fibrous sheath-interacting protein 1 OS=Homo sapiens OX=9606 GN=FSIP1 PE=2 SV=1" "1" "1" "1" "1" "581" "66.1" "5.16" "" "2.23" "" "1" "" "" "" "Pf15554" "161835" "ENSG00000150667" "FSIP1" "hsa:161835; Q6X2C8; Q86Y89; Q8NA03" "" "" "0" "0" "60.1" "70.5" "110.5" "419.3" "137.7" "77.1" "167.4" "92.7" "117.2" "608.3" "967.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "4" "1" "2" "1" "288" "31.7" "7.66" "290.70" "2.23" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "Nicotinamide salvaging" "" "1" "0" "45.3" "53.1" "72.2" "244.1" "103.3" "41.4" "55.3" "64.1" "63.1" "154.3" "128.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "2" "1" "3" "1" "468" "54.4" "5.68" "640.55" "2.23" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "Detoxification of Reactive Oxygen Species" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "n/a" "n/a" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=1" "1" "1" "2" "1" "699" "79.6" "6.02" "276.49" "2.22" "1" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "33.1" "27.7" "36.2" "99.0" "57.8" "29.4" "49.7" "40.5" "47.4" "255.7" "365.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H5Y7" "SLIT and NTRK-like protein 6 OS=Homo sapiens OX=9606 GN=SLITRK6 PE=2 SV=3" "2" "1" "1" "1" "841" "95.0" "6.52" "" "2.22" "" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf13855" "84189" "ENSG00000184564" "SLITRK6" "A8K9S8; hsa:84189; Q495Q0; Q6AW93; Q9H5Y7; Q9HAA8; Q9NT60" "Receptor-type tyrosine-protein phosphatases" "" "1" "0" "138.8" "132.8" "163.5" "680.2" "242.1" "143.5" "324.4" "186.0" "237.2" "1114.5" "785.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "6" "1" "2" "1" "225" "25.0" "5.69" "276.33" "2.22" "1" "1" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8ND04" "Protein SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1" "1" "1" "2" "1" "991" "109.6" "7.68" "279.27" "2.22" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf10220" "55181" "ENSG00000167447" "SMG8" "hsa:55181; Q8N5U5; Q8ND04; Q8TDN0; Q9H5P5; Q9NVQ1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NC60" "Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2" "2" "1" "2" "1" "698" "78.4" "8.66" "326.18" "2.22" "1" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf01926" "84273" "ENSG00000084092" "NOA1" "hsa:84273; Q8N7L6; Q8NC60; Q9BSQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "4" "1" "2" "1" "219" "24.3" "6.21" "262.64" "2.22" "1" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "" "3" "0" "24.9" "19.8" "29.4" "48.8" "29.5" "20.6" "43.8" "21.5" "21.7" "110.5" "140.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "6" "1" "2" "1" "181" "21.2" "7.49" "310.80" "2.22" "1" "1" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "G alpha (i) signalling events" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "4" "0" "0.0" "4.2" "8.3" "60.8" "14.2" "0.1" "9.2" "9.5" "12.4" "37.1" "24.4" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "1" "1" "1" "1" "795" "87.1" "6.37" "" "2.22" "" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "148.5" "141.2" "210.4" "722.0" "316.2" "130.9" "204.9" "154.0" "161.4" "292.2" "221.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14519" "Cyclin-dependent kinase 2-associated protein 1 OS=Homo sapiens OX=9606 GN=CDK2AP1 PE=1 SV=1" "11" "1" "2" "1" "115" "12.4" "9.38" "319.69" "2.21" "1" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09806" "8099" "ENSG00000111328" "CDK2AP1" "F5GYA4; hsa:8099; O14519" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15434" "RNA-binding motif, single-stranded-interacting protein 2 OS=Homo sapiens OX=9606 GN=RBMS2 PE=1 SV=1" "2" "1" "2" "1" "407" "43.9" "9.07" "287.09" "2.21" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "5939" "ENSG00000076067" "RBMS2" "hsa:5939; Q15434" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96FC9" "ATP-dependent DNA helicase DDX11 OS=Homo sapiens OX=9606 GN=DDX11 PE=1 SV=1" "1" "1" "1" "1" "970" "108.2" "7.31" "" "2.21" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf13307" "1663" "ENSG00000013573" "DDX11" "hsa:1663; Q13333; Q86VQ4; Q86W62; Q92498; Q92770; Q92998; Q92999; Q96FC9" "XBP1(S) activates chaperone genes" "" "1" "0" "33.7" "32.1" "38.8" "75.2" "53.6" "48.1" "70.5" "35.6" "36.5" "106.3" "62.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08AD1" "Calmodulin-regulated spectrin-associated protein 2 OS=Homo sapiens OX=9606 GN=CAMSAP2 PE=1 SV=3" "1" "1" "1" "1" "1489" "168.0" "6.80" "" "2.21" "" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "23271" "ENSG00000118200" "CAMSAP2" "B1APG6; hsa:23271; Q08AD1; Q08AD2; Q6PGN8; Q96FB3; Q9UG20; Q9UPS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "5" "1" "2" "1" "234" "26.1" "7.78" "283.18" "2.21" "1" "1" "cell-cell signaling;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "49.6" "43.0" "68.2" "341.5" "82.4" "57.4" "106.8" "57.0" "83.1" "237.4" "384.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00411" "DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2" "0" "1" "2" "1" "1230" "138.5" "8.98" "252.51" "2.20" "1" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00940, Pf14700" "5442" "ENSG00000099821" "POLRMT" "hsa:5442; O00411; O60370" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Mitochondrial gene expression" "3" "0" "45.9" "45.0" "78.4" "343.9" "123.2" "41.3" "168.3" "85.1" "76.1" "429.0" "298.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "1" "1" "2" "1" "501" "54.1" "8.66" "316.74" "2.20" "1" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "Amino acid metabolism" "5" "0" "31.1" "27.8" "35.3" "173.1" "53.1" "19.5" "65.6" "36.1" "41.8" "266.5" "177.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "3" "1" "2" "1" "435" "49.9" "6.27" "234.90" "2.20" "1" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Insulin receptor recycling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IZS8" "Voltage-dependent calcium channel subunit alpha-2/delta-3 OS=Homo sapiens OX=9606 GN=CACNA2D3 PE=1 SV=1" "1" "1" "1" "1" "1091" "122.9" "5.78" "" "2.19" "" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf08399, Pf08473, Pf13768" "55799" "ENSG00000157445" "CACNA2D3" "B2RPL6; hsa:55799; Q8IZS8; Q9NY16; Q9NY18" "Presynaptic depolarization and calcium channel opening" "Arrhythmogenic right ventricular cardiomyopathy; MAPK signaling pathway" "3" "0" "50.2" "60.4" "66.9" "174.5" "88.8" "70.5" "108.9" "61.5" "75.5" "258.1" "161.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5SVZ6" "Zinc finger MYM-type protein 1 OS=Homo sapiens OX=9606 GN=ZMYM1 PE=1 SV=1" "1" "1" "2" "1" "1142" "128.6" "7.44" "260.47" "2.19" "1" "1" "" "nucleus" "other molecular function" "Pf05699, Pf06467, Pf14291" "79830" "ENSG00000197056" "ZMYM1" "D3DPR7; hsa:79830; Q5SVZ6; Q7Z3Q4" "" "" "0" "0" "2.7" "4.3" "6.2" "15.2" "10.4" "3.8" "9.5" "2.1" "5.7" "31.2" "37.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14727" "Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2" "1" "1" "2" "1" "1248" "141.7" "6.40" "258.60" "2.19" "1" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00619, Pf00931, Pf17908" "317" "ENSG00000120868" "APAF1" "B2RMX8; hsa:317; O14727; O43297; Q7Z438; Q9BXZ6; Q9UBZ5; Q9UGN8; Q9UGN9; Q9UGP0; Q9UJ58; Q9UJ59; Q9UJ60; Q9UJ61; Q9UJ62; Q9UJ63; Q9UJ64; Q9UJ65; Q9UJ66; Q9UJ67; Q9UNC9" "Neutrophil degranulation; Transcriptional Regulation by E2F6; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity" "miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; CKAP4 signaling pathway map; DNA damage response" "29" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "2" "1" "3" "1" "443" "49.3" "5.69" "545.49" "2.19" "1" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "Apoptotic cleavage of cellular proteins" "" "2" "0" "120.2" "112.3" "176.2" "559.5" "242.0" "110.4" "264.7" "144.7" "138.4" "375.0" "307.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "8" "3" "3" "3" "359" "39.6" "7.17" "530.10" "2.19" "2" "1" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin activation and detoxification" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "3" "0" "297.4" "235.5" "428.0" "902.3" "467.9" "217.6" "464.2" "255.1" "409.3" "669.1" "456.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "4" "1" "2" "1" "210" "24.5" "5.95" "305.81" "2.19" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "35.3" "42.0" "42.9" "110.4" "61.0" "42.6" "81.9" "56.3" "133.3" "456.0" "312.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TD31" "Coiled-coil alpha-helical rod protein 1 OS=Homo sapiens OX=9606 GN=CCHCR1 PE=1 SV=2" "1" "1" "1" "1" "782" "88.6" "5.95" "" "2.19" "" "1" "transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf07111" "54535" "ENSG00000204536; ENSG00000206355; ENSG00000206457; ENSG00000234114" "CCHCR1" "A2ABH6; E9PE84; hsa:54535; Q2TB67; Q5SQ82; Q5STE9; Q8TD31; Q9NRK8; Q9NWY9; Q9NXJ4; Q9NXK3; Q9Y6W1; Q9Y6W2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "O95985" "DNA topoisomerase 3-beta-1 OS=Homo sapiens OX=9606 GN=TOP3B PE=1 SV=1" "1" "1" "2" "1" "862" "96.6" "8.12" "233.45" "2.19" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01751" "8940" "ENSG00000100038" "TOP3B" "A0M8Q3; hsa:8940; O95985; Q9BUP5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P04637" "Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4" "2" "1" "2" "1" "393" "43.6" "6.79" "254.48" "2.19" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00870, Pf07710, Pf08563, Pf18521" "7157" "ENSG00000141510" "TP53" "hsa:7157; P04637; Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98; Q3LRW1; Q3LRW2; Q3LRW3; Q3LRW4; Q3LRW5; Q86UG1; Q8J016; Q99659; Q9BTM4; Q9HAQ8; Q9NP68; Q9NPJ2; Q9NZD0; Q9UBI2; Q9UQ61" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-4 and Interleukin-13 signaling; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Factors involved in megakaryocyte development and platelet production; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; Regulation of NF-kappa B signaling; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional activation of cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Pleural mesothelioma; Lipid metabolism in senescent cells; DYRK1A involvement regarding cell proliferation in brain development; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma; 11p11.2 copy number variation syndrome ; A network map of Macrophage-stimulating protein (MSP) signaling; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "107" "0" "55.2" "77.0" "89.2" "214.2" "116.6" "74.0" "140.5" "96.0" "84.5" "231.4" "209.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5JTZ9" "Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1" "1" "1" "2" "1" "985" "107.3" "6.27" "290.78" "2.19" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01411, Pf07973" "57505" "ENSG00000124608" "AARS2" "A2RRN5; hsa:57505; Q5JTZ9; Q8N198; Q96D02; Q9ULF0" "Mitochondrial tRNA aminoacylation" "Primary ovarian insufficiency" "2" "0" "39.6" "53.2" "56.1" "297.0" "102.6" "31.2" "71.2" "76.3" "48.6" "110.5" "120.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BUT1" "3-hydroxybutyrate dehydrogenase type 2 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "2" "1" "2" "1" "245" "26.7" "7.65" "252.92" "2.18" "1" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "Synthesis of Ketone Bodies" "" "1" "0" "78.1" "78.6" "102.1" "283.7" "156.7" "75.0" "120.2" "78.6" "105.8" "251.0" "299.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "4" "1" "2" "1" "197" "22.6" "7.11" "280.68" "2.18" "1" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "95.6" "82.8" "98.0" "470.9" "170.6" "64.6" "121.4" "86.0" "123.9" "299.4" "238.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NBM4" "Ubiquitin-associated domain-containing protein 2 OS=Homo sapiens OX=9606 GN=UBAC2 PE=1 SV=1" "2" "1" "1" "1" "344" "38.9" "9.01" "" "2.18" "" "1" "cell-cell signaling;signal transduction;other biological processes" "other membranes;ER/Golgi" "" "Pf00627" "337867" "ENSG00000134882" "UBAC2" "B3KNV7; hsa:337867; Q0VAB5; Q5W0W6; Q5W0W9; Q6GQR2; Q6P4B0; Q8N2E8; Q8NBM4; Q96NW2" "" "" "0" "0" "18.6" "20.6" "27.6" "94.0" "40.9" "14.5" "36.2" "27.7" "18.0" "75.1" "71.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "28" "2" "3" "2" "75" "8.7" "5.45" "712.59" "2.18" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; RAC2 GTPase cycle; RAC3 GTPase cycle" "Regulation of actin cytoskeleton" "8" "0" "84.3" "81.1" "101.4" "244.0" "139.1" "97.6" "191.0" "101.0" "118.3" "565.5" "591.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6ZXV5" "Protein O-mannosyl-transferase TMTC3 OS=Homo sapiens OX=9606 GN=TMTC3 PE=1 SV=2" "1" "1" "1" "1" "915" "103.9" "8.87" "" "2.18" "" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf08409, Pf13174, Pf13181, Pf13431" "160418" "ENSG00000139324" "TMTC3" "hsa:160418; Q5CZ86; Q5H9T6; Q68DQ6; Q68DX0; Q6ZXV5; Q7Z332; Q8NC50" "" "" "0" "0" "4.9" "6.2" "8.4" "22.1" "15.1" "10.2" "9.8" "6.6" "3.8" "32.6" "48.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IYX1" "TBC1 domain family member 21 OS=Homo sapiens OX=9606 GN=TBC1D21 PE=1 SV=1" "4" "1" "1" "1" "336" "39.2" "6.19" "" "2.18" "" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf00566" "161514" "ENSG00000167139" "TBC1D21" "B9A6M2; hsa:161514; Q8IYX1" "" "" "0" "0" "123.0" "83.2" "127.0" "291.3" "140.9" "79.0" "143.0" "108.0" "117.1" "433.5" "392.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z2W9" "39S ribosomal protein L21, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "5" "1" "2" "1" "205" "22.8" "9.89" "268.32" "2.18" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "58.6" "61.3" "65.8" "242.2" "102.0" "62.4" "102.1" "72.4" "62.4" "229.1" "184.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "1" "1" "2" "1" "907" "102.3" "7.14" "269.78" "2.17" "1" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "ISG15 antiviral mechanism" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "4" "0" "74.9" "74.4" "86.4" "321.7" "134.9" "82.8" "135.0" "87.1" "99.0" "275.5" "234.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N9T8" "Protein KRI1 homolog OS=Homo sapiens OX=9606 GN=KRI1 PE=1 SV=3" "1" "1" "2" "1" "703" "82.5" "5.14" "306.70" "2.17" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05178, Pf12936" "65095" "ENSG00000129347" "KRI1" "hsa:65095; Q2M1R5; Q2M1R7; Q7L5J7; Q8N9T8; Q96G92; Q9BU50; Q9H6I1; Q9H978" "" "" "0" "0" "34.3" "29.0" "44.2" "99.8" "56.1" "36.3" "62.0" "38.1" "35.8" "99.2" "74.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10243" "Myb-related protein A OS=Homo sapiens OX=9606 GN=MYBL1 PE=1 SV=2" "1" "1" "2" "1" "752" "85.8" "7.12" "231.70" "2.17" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf07988, Pf09316, Pf13921" "4603" "ENSG00000185697" "MYBL1" "E7EW29; hsa:4603; P10243; Q495F9" "PIWI-interacting RNA (piRNA) biogenesis" "Pre-implantation embryo; Pathways affected in adenoid cystic carcinoma" "3" "0" "97.1" "109.7" "168.4" "849.3" "290.5" "103.4" "162.4" "121.6" "145.2" "446.5" "527.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HC84" "Mucin-5B OS=Homo sapiens OX=9606 GN=MUC5B PE=1 SV=3" "0" "1" "2" "1" "5762" "596.0" "6.64" "243.69" "2.17" "1" "1" "" "extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00094, Pf01826, Pf08742, Pf13330" "727897" "ENSG00000117983" "MUC5B" "hsa:727897; O00447; O00573; O14985; O15494; O95291; O95451; Q14881; Q7M4S5; Q99552; Q9HC84; Q9UE28" "Dectin-2 family; Termination of O-glycan biosynthesis; Defective GALNT3 causes HFTC; Defective C1GALT1C1 causes TNPS; Defective GALNT12 causes CRCS1" "Lung fibrosis" "7" "0" "12.4" "10.6" "12.8" "18.9" "16.7" "9.6" "16.6" "16.3" "12.6" "25.6" "20.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WZ82" "Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1" "4" "1" "2" "1" "227" "24.4" "6.89" "265.31" "2.17" "1" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf03959" "124641" "ENSG00000262664" "OVCA2" "hsa:124641; Q86XN3; Q8IW87; Q8WZ82; Q9UCX9" "" "" "0" "0" "38.3" "35.5" "77.3" "219.1" "98.6" "33.5" "76.0" "59.3" "64.5" "169.7" "161.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UPW5" "Cytosolic carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=AGTPBP1 PE=1 SV=3" "1" "1" "2" "1" "1226" "138.4" "6.15" "240.04" "2.17" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00246, Pf18027" "23287" "ENSG00000135049" "AGTPBP1" "B4DIT6; B4DRZ8; hsa:23287; Q5VV80; Q63HM7; Q658P5; Q6P9D6; Q9H8U6; Q9H9W8; Q9NVK1; Q9UPW5" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "3.5" "5.5" "7.7" "20.0" "12.4" "5.7" "13.0" "5.2" "6.0" "22.7" "16.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "1" "1" "1" "1" "732" "81.2" "5.48" "" "2.17" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "Neutrophil degranulation; Eukaryotic Translation Termination" "" "2" "0" "125.4" "142.6" "177.8" "978.8" "321.7" "52.9" "104.4" "160.2" "91.2" "207.1" "255.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A6PVS8" "Leucine-rich repeat and IQ domain-containing protein 3 OS=Homo sapiens OX=9606 GN=LRRIQ3 PE=1 SV=1" "2" "1" "1" "1" "624" "73.6" "9.72" "" "2.17" "" "1" "" "" "" "Pf12799" "127255" "ENSG00000162620" "LRRIQ3" "A6PVS8; A6PVS9; hsa:127255; Q6P5P7; Q6ZMV4; Q8WUE0" "" "" "0" "0" "215.9" "181.4" "206.7" "230.7" "197.2" "171.9" "211.8" "162.0" "177.7" "233.8" "211.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P68402" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1" "4" "1" "2" "1" "229" "25.6" "5.92" "290.32" "2.17" "1" "1" "other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13472" "5049" "ENSG00000168092" "PAFAH1B2" "A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "" "2" "0" "42.8" "45.4" "69.5" "203.0" "104.4" "36.2" "51.9" "64.4" "43.7" "78.0" "69.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0" "1" "1" "1" "2961" "330.9" "5.95" "" "2.17" "" "1" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "16.7" "13.6" "16.9" "41.8" "24.1" "19.4" "20.2" "10.6" "16.5" "30.5" "23.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "1" "1" "2" "1" "1250" "141.0" "5.31" "287.77" "2.16" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "n/a" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "1" "1" "2" "1" "963" "105.0" "7.05" "239.28" "2.16" "1" "1" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron uptake and transport" "Iron metabolism in placenta; Ferroptosis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "2" "1" "1" "1" "525" "58.2" "6.92" "" "2.16" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "Mitochondrial protein import; Processing of SMDT1" "" "2" "0" "70.2" "113.3" "88.4" "167.0" "82.3" "65.4" "117.5" "69.7" "95.7" "243.0" "217.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43166" "Signal-induced proliferation-associated 1-like protein 1 OS=Homo sapiens OX=9606 GN=SIPA1L1 PE=1 SV=4" "1" "1" "1" "1" "1804" "199.9" "8.19" "" "2.16" "" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf02145, Pf11881" "26037" "ENSG00000197555" "SIPA1L1" "hsa:26037; J3KP19; O43166; O95321; Q9UDU4; Q9UNU4" "Neurexins and neuroligins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "6" "1" "1" "1" "111" "12.0" "9.83" "" "2.16" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "Termination of translesion DNA synthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7L1Q6" "Basic leucine zipper and W2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "1" "1" "2" "1" "419" "48.0" "5.92" "248.33" "2.16" "1" "1" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "35.1" "38.7" "59.0" "233.6" "88.4" "35.1" "65.0" "46.9" "43.7" "175.6" "220.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=2" "1" "1" "1" "1" "403" "45.8" "9.39" "" "2.16" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "100973908; 469980" "ENSPPAG00000031434; ENSPTRG00000013646" "AURKA" "A0A2J8JWB7; A0A2R9ANX1; A0A6D2Y5M9; G2HFJ0; pps:100973908; ptr:469980" "" "" "0" "0" "29.2" "34.0" "39.0" "122.9" "50.8" "22.2" "61.8" "28.2" "48.1" "258.7" "171.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "2" "1" "2" "1" "676" "77.5" "7.75" "240.94" "2.16" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Interferon gamma signaling; Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; VEGFR2 mediated cell proliferation; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "47" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q659A1" "Little elongation complex subunit 2 OS=Homo sapiens OX=9606 GN=ICE2 PE=1 SV=2" "1" "1" "1" "1" "982" "109.9" "7.09" "" "2.16" "" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10505" "79664" "ENSG00000128915" "ICE2" "B2RU08; hsa:79664; Q05CT1; Q3B7W6; Q63HP4; Q658Q0; Q659A1; Q68CN8; Q6IPW7; Q6UX23; Q71H65; Q96CY5; Q9HAA2" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "552.5" "477.5" "477.7" "704.3" "494.0" "402.3" "835.5" "381.1" "368.1" "820.4" "395.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A6NCE7" "Microtubule-associated proteins 1A/1B light chain 3 beta 2 OS=Homo sapiens OX=9606 GN=MAP1LC3B2 PE=2 SV=1" "8" "1" "1" "1" "125" "14.6" "8.68" "" "2.16" "" "1" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "643246" "ENSG00000258102" "MAP1LC3B2" "A6NCE7; hsa:643246" "" "" "0" "0" "68.9" "49.5" "124.5" "316.5" "143.8" "69.5" "189.9" "76.6" "119.9" "260.2" "183.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "1" "1" "1" "1" "1015" "114.3" "5.59" "" "2.16" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "Condensation of Prometaphase Chromosomes" "" "1" "0" "61.8" "46.9" "80.3" "231.4" "105.0" "61.0" "108.1" "48.6" "52.7" "149.5" "103.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15050" "Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2" "3" "1" "2" "1" "365" "41.2" "10.70" "303.47" "2.16" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf04939" "23212" "ENSG00000179041" "RRS1" "hsa:23212; Q15050; Q9BUX8" "" "" "0" "0" "25.1" "22.1" "27.8" "61.1" "39.8" "29.1" "50.5" "15.2" "22.2" "52.1" "21.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0" "1" "1" "1" "1360" "152.7" "6.90" "" "2.15" "" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "8" "0" "110.6" "98.2" "138.4" "398.6" "181.0" "99.1" "212.5" "125.7" "146.4" "497.8" "459.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "E9PRG8" "Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=4 SV=2" "6" "1" "2" "1" "123" "14.2" "11.53" "288.75" "2.15" "1" "1" "" "" "" "Pf17719" "102288414" "ENSG00000278615" "C11orf98" "A0A0B4J220; E9PRG8; hsa:102288414" "" "" "0" "0" "119.7" "85.9" "109.5" "202.3" "133.0" "91.6" "154.6" "68.5" "122.8" "305.9" "216.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P31944" "Caspase-14 OS=Homo sapiens OX=9606 GN=CASP14 PE=1 SV=2" "10" "2" "3" "2" "242" "27.7" "5.58" "536.09" "2.15" "2" "1" "protein metabolism;other biological processes" "plasma membrane;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00656" "23581" "ENSG00000105141" "CASP14" "hsa:23581; O95823; P31944; Q3SYC9" "Formation of the cornified envelope" "Vitamin D receptor pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBK8" "Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4" "2" "1" "1" "1" "698" "77.6" "6.49" "" "2.14" "" "1" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00175, Pf00258, Pf00667" "4552" "ENSG00000124275" "MTRR" "hsa:4552; O60471; Q32MA9; Q7Z4M8; Q9UBK8" "Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Male infertility" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UJT2" "Testis-specific serine kinase substrate OS=Homo sapiens OX=9606 GN=TSKS PE=1 SV=3" "2" "1" "1" "1" "592" "65.0" "5.97" "" "2.14" "" "1" "" "cytoskeleton;other cell component" "other molecular function" "Pf15358" "60385" "ENSG00000126467" "TSKS" "hsa:60385; Q8WXJ0; Q9UJT2" "" "22q11.2 copy number variation syndrome" "1" "0" "69.3" "51.0" "67.6" "97.5" "81.4" "58.0" "69.8" "52.8" "67.9" "108.6" "87.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y6J9" "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens OX=9606 GN=TAF6L PE=1 SV=1" "2" "1" "1" "1" "622" "67.8" "8.97" "" "2.14" "" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "10629" "ENSG00000162227" "TAF6L" "B2RAT0; hsa:10629; Q96HA6; Q9Y6J9" "HATs acetylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "5" "1" "1" "1" "167" "19.4" "7.40" "" "2.14" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q99741" "Cell division control protein 6 homolog OS=Homo sapiens OX=9606 GN=CDC6 PE=1 SV=1" "1" "1" "1" "1" "560" "62.7" "9.58" "" "2.14" "" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf09079, Pf13401, Pf17872" "990" "ENSG00000094804" "CDC6" "hsa:990; Q8TB30; Q99741" "Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; G1/S-Specific Transcription; Transcription of E2F targets under negative control by DREAM complex" "Cell cycle; DNA replication" "10" "0" "51.6" "43.6" "55.4" "181.4" "83.6" "39.6" "82.0" "51.9" "61.4" "178.4" "175.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P0CG22" "Putative dehydrogenase/reductase SDR family member 4-like 1 OS=Homo sapiens OX=9606 GN=DHRS4L1 PE=5 SV=1" "5" "1" "1" "1" "281" "30.6" "9.77" "" "2.13" "" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf13561" "" "" "DHRS4L1" "P0CG22" "" "" "0" "0" "14.8" "18.7" "18.2" "35.2" "13.0" "21.0" "37.8" "45.6" "74.2" "339.6" "341.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96RY7" "Intraflagellar transport protein 140 homolog OS=Homo sapiens OX=9606 GN=IFT140 PE=1 SV=1" "1" "1" "2" "1" "1462" "165.1" "6.04" "243.95" "2.13" "1" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "" "9742" "ENSG00000187535" "IFT140" "A2A2A8; D3DU75; hsa:9742; O60332; Q96RY7; Q9UG52" "Hedgehog 'off' state; Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q02224" "Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2" "1" "2" "2" "1" "2701" "316.2" "5.64" "263.11" "2.13" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "1062" "ENSG00000138778" "CENPE" "A6NKY9; A8K2U7; hsa:1062; Q02224; Q4LE75" "RHO GTPases Activate Formins; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Regulation of sister chromatid separation at the metaphase-anaphase transition" "10" "0" "3.1" "4.2" "5.5" "26.3" "9.5" "3.4" "10.5" "4.5" "3.4" "41.5" "24.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "4" "1" "1" "1" "260" "30.5" "5.21" "" "2.12" "" "1" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Pyrimidine salvage; Purine salvage" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "6.5" "7.7" "9.0" "48.9" "14.6" "2.1" "8.9" "9.3" "8.0" "23.4" "17.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4D8" "Probable E3 ubiquitin-protein ligase HECTD4 OS=Homo sapiens OX=9606 GN=HECTD4 PE=1 SV=5" "0" "2" "3" "1" "3996" "439.1" "6.19" "477.49" "2.12" "2" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes" "other molecular function" "Pf00632" "" "" "HECTD4" "L8B0P6; Q3MJD5; Q6P0A0; Q7L530; Q8NB70; Q8WU73; Q96NT9; Q9NZS4; Q9UFT6; Q9Y4D8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P06850" "Corticoliberin OS=Homo sapiens OX=9606 GN=CRH PE=1 SV=1" "7" "1" "1" "1" "196" "21.4" "9.96" "" "2.12" "" "1" "cell-cell signaling;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding" "Pf00473" "1392" "ENSG00000147571" "CRH" "B3KQS4; hsa:1392; P06850" "G alpha (s) signalling events; Class B/2 (Secretin family receptors); MECP2 regulates transcription of neuronal ligands" "Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Serotonin and anxiety-related events; Serotonin and anxiety; Orexin receptor pathway" "8" "0" "57.1" "52.9" "64.8" "66.5" "65.6" "42.2" "53.3" "45.2" "52.5" "84.9" "93.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "4" "1" "1" "1" "277" "31.6" "6.54" "" "2.12" "" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Other interleukin signaling; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; CKAP4 signaling pathway map; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "61" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "n/a" "1" "" "False" "IsMasterProtein" "P21359" "Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2" "0" "1" "1" "1" "2839" "319.2" "7.39" "" "2.12" "" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf13716" "4763" "ENSG00000196712" "NF1" "hsa:4763; O00662; P21359; Q14284; Q14930; Q14931; Q9UMK3" "Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants" "Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance" "13" "0" "14.8" "12.3" "17.9" "57.7" "26.3" "14.5" "27.3" "19.4" "18.0" "66.1" "61.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NXF1" "Testis-expressed protein 10 OS=Homo sapiens OX=9606 GN=TEX10 PE=1 SV=2" "1" "1" "2" "1" "929" "105.6" "9.36" "252.14" "2.11" "1" "1" "" "mitochondrion;nucleus" "" "Pf12333" "54881" "ENSG00000136891" "TEX10" "B4DYV2; hsa:54881; Q5T722; Q5T723; Q8NCN8; Q8TDY0; Q9NXF1" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "B2RBV5" "Putative MORF4 family-associated protein 1-like protein UPP OS=Homo sapiens OX=9606 PE=1 SV=1" "10" "1" "1" "1" "119" "13.4" "8.22" "" "2.11" "" "1" "other biological processes" "" "" "Pf15155" "" "" "MRFAP1L2" "B2RBV5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "1" "1" "1" "1" "1056" "119.1" "5.64" "" "2.11" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P2N4" "A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens OX=9606 GN=ADAMTS9 PE=1 SV=4" "1" "1" "1" "1" "1935" "216.4" "7.77" "" "2.11" "" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "other molecular function" "Pf00090, Pf01421, Pf01562, Pf05986, Pf08685, Pf17771, Pf19030, Pf19236" "56999" "ENSG00000163638" "ADAMTS9" "A1L4L0; B7ZVX9; B9ZVN0; hsa:56999; Q9NR29; Q9P2N4" "Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins; Degradation of the extracellular matrix" "VEGFA-VEGFR2 signaling" "4" "0" "34.5" "24.7" "40.3" "91.7" "58.8" "41.1" "71.6" "36.3" "49.5" "135.9" "115.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "2" "1" "2" "1" "331" "36.5" "4.79" "236.59" "2.11" "1" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis induced DNA fragmentation" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "4" "0" "116.6" "95.6" "201.4" "591.9" "278.7" "82.8" "230.7" "138.6" "171.8" "195.8" "148.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96T53" "Ghrelin O-acyltransferase OS=Homo sapiens OX=9606 GN=MBOAT4 PE=1 SV=2" "3" "1" "1" "1" "435" "49.7" "8.47" "" "2.11" "" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf03062" "619373" "ENSG00000177669" "MBOAT4" "B1Q003; hsa:619373; Q96T53" "Synthesis, secretion, and deacylation of Ghrelin" "" "1" "0" "63.4" "53.1" "76.2" "180.4" "95.0" "69.5" "95.0" "48.1" "69.6" "164.7" "122.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8NFA0" "Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens OX=9606 GN=USP32 PE=1 SV=1" "1" "1" "1" "1" "1604" "181.5" "6.44" "" "2.11" "" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf06337, Pf13202" "84669" "ENSG00000170832" "USP32" "hsa:84669; Q7Z5T3; Q8NFA0; Q9BX85; Q9Y591" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "2" "1" "2" "1" "671" "74.3" "7.49" "265.86" "2.11" "1" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "hsa:84717; I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRM2" "Zinc finger protein 277 OS=Homo sapiens OX=9606 GN=ZNF277 PE=1 SV=2" "2" "1" "2" "1" "450" "52.8" "5.34" "249.29" "2.10" "1" "1" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12756" "11179" "ENSG00000198839" "ZNF277" "hsa:11179; Q75MZ2; Q75MZ3; Q8WY14; Q9NRM2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "n/a" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UL68" "Myelin transcription factor 1-like protein OS=Homo sapiens OX=9606 GN=MYT1L PE=2 SV=3" "1" "1" "1" "1" "1186" "133.0" "4.97" "" "2.10" "" "1" "RNA metabolism OR transcription;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01530, Pf08474" "23040" "ENSG00000186487" "MYT1L" "A7E2C7; B2RP54; hsa:23040; Q6IQ17; Q9UL68; Q9UPP6" "" "" "0" "0" "67.0" "45.9" "70.2" "192.4" "112.6" "59.4" "138.4" "61.6" "65.6" "235.1" "156.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VV42" "Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Homo sapiens OX=9606 GN=CDKAL1 PE=1 SV=1" "2" "1" "3" "1" "579" "65.1" "7.46" "483.87" "2.10" "1" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00919, Pf01938, Pf04055" "54901" "ENSG00000145996" "CDKAL1" "A8K6S0; hsa:54901; Q5VV42; Q6P385; Q6ZR27; Q9NXB3" "tRNA modification in the nucleus and cytosol" "Vitamin D receptor pathway" "2" "0" "18.8" "18.7" "30.2" "63.8" "36.1" "24.0" "41.2" "17.0" "23.8" "59.1" "44.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "2" "1" "2" "1" "563" "61.2" "6.48" "287.60" "2.09" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "XBP1(S) activates chaperone genes" "VEGFA-VEGFR2 signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNS1" "Protein timeless homolog OS=Homo sapiens OX=9606 GN=TIMELESS PE=1 SV=2" "1" "1" "1" "1" "1208" "138.6" "5.40" "" "2.09" "" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04821, Pf05029" "8914" "ENSG00000111602" "TIMELESS" "B2ZAV0; hsa:8914; O94802; Q86VM1; Q8IWH3; Q9UNS1" "Processing of DNA double-strand break ends" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q3MIT2" "tRNA pseudouridine synthase Pus10 OS=Homo sapiens OX=9606 GN=PUS10 PE=1 SV=1" "3" "1" "1" "1" "529" "60.2" "6.54" "" "2.09" "" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "150962" "ENSG00000162927" "PUS10" "hsa:150962; Q3MIT2; Q5JPJ5; Q96MI8" "" "" "0" "0" "65.3" "59.1" "85.6" "318.5" "106.3" "63.5" "126.6" "63.0" "99.7" "387.3" "308.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96M96" "FYVE, RhoGEF and PH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=FGD4 PE=1 SV=2" "1" "1" "1" "1" "766" "86.6" "6.13" "" "2.08" "" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00621, Pf01363" "121512" "ENSG00000139132" "FGD4" "hsa:121512; Q6ULS2; Q8TCP6; Q96M96" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Intracellular trafficking proteins involved in CMT neuropathy" "6" "0" "18.8" "20.3" "31.8" "174.4" "46.8" "18.2" "29.8" "26.9" "28.2" "53.9" "40.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P22695" "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" "2" "1" "2" "1" "453" "48.4" "8.63" "254.06" "2.08" "1" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00675, Pf05193" "7385" "ENSG00000140740" "UQCRC2" "B3KSN4; hsa:7385; P22695; Q9BQ05" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "6" "1" "1" "1" "358" "40.6" "5.94" "" "2.08" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; ATM signaling in development and disease ; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "3" "1" "1" "1" "235" "25.2" "7.59" "" "2.08" "" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51956" "Serine/threonine-protein kinase Nek3 OS=Homo sapiens OX=9606 GN=NEK3 PE=1 SV=2" "2" "1" "2" "1" "506" "57.7" "7.17" "247.34" "2.08" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "4752" "ENSG00000136098" "NEK3" "A8K2J4; hsa:4752; P51956; Q5TAP2; Q8J023; Q8WUN5" "" "Prolactin signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "n/a" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15228" "Dihydroxyacetone phosphate acyltransferase OS=Homo sapiens OX=9606 GN=GNPAT PE=1 SV=1" "2" "1" "1" "1" "680" "77.1" "6.57" "" "2.08" "" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01553, Pf19277" "8443" "ENSG00000116906" "GNPAT" "B4DNM9; hsa:8443; O15228; Q5TBH7; Q9BWC2" "Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA" "Triacylglyceride synthesis" "4" "0" "201.1" "206.0" "230.7" "461.2" "270.1" "205.6" "368.1" "173.6" "193.7" "485.0" "263.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WWH5" "Probable tRNA pseudouridine synthase 1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1" "3" "1" "2" "1" "349" "37.2" "8.25" "268.42" "2.08" "1" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01509" "142940" "ENSG00000165832" "TRUB1" "B2R716; hsa:142940; Q53ES2; Q8WWH5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "1" "1" "2" "1" "920" "106.1" "9.98" "271.91" "2.07" "1" "1" "RNA metabolism OR transcription;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "" "Interactome of polycomb repressive complex 2 (PRC2)" "1" "0" "110.8" "85.9" "130.5" "295.3" "184.4" "117.6" "166.0" "80.5" "97.3" "219.0" "113.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WVX9" "Fatty acyl-CoA reductase 1 OS=Homo sapiens OX=9606 GN=FAR1 PE=1 SV=1" "2" "1" "1" "1" "515" "59.3" "9.17" "" "2.07" "" "1" "other metabolic processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf03015, Pf07993" "84188" "ENSG00000197601" "FAR1" "D3DQW8; hsa:84188; Q5CZA3; Q8WVX9" "Wax biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "n/a" "n/a" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N3P4" "Vacuolar protein sorting-associated protein 8 homolog OS=Homo sapiens OX=9606 GN=VPS8 PE=1 SV=3" "1" "1" "1" "1" "1428" "161.7" "5.64" "" "2.07" "" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf12816" "23355" "ENSG00000156931" "VPS8" "A8K8Q8; B9EIQ1; C9JB61; hsa:23355; O94896; Q63HP2; Q8N3P4; Q9BVP9; Q9H9B0" "" "" "0" "0" "169.7" "114.2" "269.6" "577.0" "382.8" "239.9" "416.4" "65.7" "150.5" "324.3" "99.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "2" "1" "2" "1" "501" "54.1" "6.24" "231.85" "2.07" "1" "1" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "n/a" "High" "n/a" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "3" "1" "1" "1" "362" "39.3" "5.52" "" "2.07" "" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Retrograde transport at the Trans-Golgi-Network" "Metapathway biotransformation Phase I and II" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P0DI83" "Ras-related protein Rab-34, isoform NARR OS=Homo sapiens OX=9606 GN=RAB34 PE=1 SV=1" "9" "1" "2" "1" "198" "21.1" "12.16" "376.81" "2.06" "1" "1" "" "nucleus" "" "" "83871" "ENSG00000109113" "RAB34" "P0DI83" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "5" "1" "2" "1" "215" "23.9" "6.21" "268.63" "2.06" "1" "1" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZC9" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1" "1" "1" "2" "1" "954" "105.9" "9.06" "251.26" "2.06" "1" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07443" "50485" "ENSG00000138375" "SMARCAL1" "A6NEH0; hsa:50485; Q53R00; Q96AY1; Q9NXQ5; Q9NZC9; Q9UFH3; Q9UI93" "" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6KC79" "Nipped-B-like protein OS=Homo sapiens OX=9606 GN=NIPBL PE=1 SV=2" "0" "1" "1" "1" "2804" "315.9" "7.91" "" "2.06" "" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12765, Pf12830" "25836" "ENSG00000164190" "NIPBL" "hsa:25836; Q6KC79; Q6KCD6; Q6N080; Q6ZT92; Q7Z2E6; Q8N4M5; Q9Y6Y3; Q9Y6Y4" "Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BTT6" "Leucine-rich repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRRC1 PE=1 SV=1" "2" "1" "1" "1" "524" "59.2" "5.02" "" "2.06" "" "1" "" "other membranes;cytosol" "" "Pf13855" "55227" "ENSG00000137269" "LRRC1" "hsa:55227; Q5TGN3; Q9BTT6; Q9HAC0; Q9NVF1" "RND2 GTPase cycle" "" "1" "0" "209.9" "145.4" "186.0" "210.4" "186.7" "194.1" "203.8" "123.4" "137.1" "223.4" "167.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6ZSC3" "RNA-binding protein 43 OS=Homo sapiens OX=9606 GN=RBM43 PE=1 SV=1" "3" "1" "1" "1" "357" "40.6" "9.66" "" "2.05" "" "1" "" "" "nucleic acid binding activity" "" "375287" "ENSG00000184898" "RBM43" "B2RMT5; hsa:375287; Q6ZSC3" "" "" "0" "0" "16.3" "24.3" "30.0" "57.4" "30.4" "22.8" "40.5" "23.4" "26.3" "66.8" "38.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "1" "1" "2" "1" "985" "108.1" "8.32" "285.27" "2.05" "1" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "" "Primary ovarian insufficiency" "1" "0" "41.3" "33.8" "42.4" "67.6" "42.2" "29.0" "45.9" "18.0" "34.9" "53.6" "24.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NUP7" "tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens OX=9606 GN=TRMT13 PE=1 SV=2" "2" "1" "1" "1" "481" "54.2" "8.09" "" "2.05" "" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf05206, Pf05253, Pf11722" "54482" "ENSG00000122435" "TRMT13" "hsa:54482; Q5VVL0; Q9NUP7; Q9NW65" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "3" "1" "1" "1" "371" "42.4" "5.35" "" "2.05" "" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Estrogen-dependent gene expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; Maturation of nucleoprotein" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "3" "1" "2" "1" "376" "42.5" "5.57" "280.88" "2.05" "1" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "mRNA Splicing - Major Pathway" "" "1" "0" "4.7" "8.1" "8.0" "20.2" "12.6" "5.4" "12.2" "6.9" "7.6" "11.9" "13.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P2K8" "eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3" "1" "2" "3" "2" "1649" "186.8" "6.28" "624.93" "2.05" "2" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf05773, Pf12745, Pf13393" "440275" "ENSG00000128829" "EIF2AK4" "C9JEC4; hsa:440275; Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9P2K8; Q9UJ56" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "Measles virus infection" "2" "0" "18.0" "12.0" "18.3" "44.7" "21.8" "15.2" "32.2" "16.5" "22.1" "62.8" "41.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "3" "1" "2" "1" "394" "44.2" "9.09" "263.10" "0.00" "1" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Reversal of alkylation damage by DNA dioxygenases" "" "1" "0" "89.3" "54.9" "82.2" "130.1" "99.1" "74.5" "131.0" "40.8" "83.8" "185.0" "107.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96CS2" "HAUS augmin-like complex subunit 1 OS=Homo sapiens OX=9606 GN=HAUS1 PE=1 SV=1" "6" "1" "2" "1" "278" "31.8" "5.53" "237.14" "0.00" "1" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "" "115106" "ENSG00000152240" "HAUS1" "B2RDM7; hsa:115106; Q8N837; Q96CS2" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "0.0" "0.0" "4.6" "20.0" "3.3" "3.2" "5.9" "2.5" "4.2" "37.5" "33.5" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13424" "Alpha-1-syntrophin OS=Homo sapiens OX=9606 GN=SNTA1 PE=1 SV=1" "5" "1" "1" "1" "505" "53.9" "6.80" "" "0.00" "" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00595, Pf18012" "6640" "ENSG00000101400" "SNTA1" "A8K7H9; B4DX40; E1P5N1; hsa:6640; Q13424; Q16438" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "5" "1" "1" "1" "261" "29.8" "5.55" "" "0.00" "" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "3.1" "6.0" "11.4" "22.4" "14.6" "9.5" "13.6" "6.3" "9.5" "13.2" "3.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P021" "Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1" "12" "1" "2" "1" "101" "11.2" "9.47" "981.50" "" "1" "" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10235" "9419" "ENSG00000119878" "CRIPT" "hsa:9419; Q9P021" "" "" "0" "0" "88.3" "54.2" "59.2" "96.0" "81.1" "49.3" "107.3" "54.9" "76.0" "244.3" "238.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95166" "Gamma-aminobutyric acid receptor-associated protein OS=Homo sapiens OX=9606 GN=GABARAP PE=1 SV=1" "26" "2" "2" "2" "117" "13.9" "8.79" "958.03" "" "2" "" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11337" "ENSG00000170296" "GABARAP" "hsa:11337; O95166" "Macroautophagy; TBC/RABGAPs" "2q37 copy number variation syndrome" "3" "0" "173.4" "120.4" "177.4" "287.0" "191.7" "152.3" "304.1" "106.8" "172.9" "490.7" "423.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "8" "2" "2" "2" "248" "27.6" "5.30" "817.04" "" "2" "" "other metabolic processes" "" "other molecular function" "Pf13472" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "37.7" "37.3" "111.0" "239.5" "153.4" "30.2" "251.0" "86.1" "96.6" "311.4" "125.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "9" "2" "2" "2" "254" "29.0" "5.50" "770.74" "" "2" "" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "12" "0" "91.4" "92.0" "119.1" "324.9" "150.5" "79.2" "129.7" "78.3" "90.9" "190.8" "152.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "1" "2" "2" "2" "2115" "238.1" "5.78" "720.14" "" "2" "" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "5" "0" "131.2" "120.4" "128.6" "260.6" "151.5" "98.5" "213.5" "104.1" "113.0" "204.3" "104.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UNZ5" "Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1" "16" "2" "2" "2" "99" "10.6" "11.55" "667.46" "" "2" "" "" "" "" "Pf09495" "28974" "ENSG00000104979" "C19orf53" "B2R4J9; hsa:28974; Q9UNZ5" "" "" "0" "0" "419.4" "326.6" "449.1" "724.6" "556.1" "348.7" "715.4" "312.8" "442.3" "830.8" "442.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "16" "1" "1" "1" "90" "10.3" "6.29" "662.91" "" "1" "" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "Mitochondrial protein import" "" "1" "0" "17.1" "17.1" "30.1" "194.3" "66.8" "15.2" "44.9" "28.6" "42.3" "81.6" "58.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "4" "2" "2" "2" "389" "45.5" "5.62" "661.25" "" "2" "" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "Separation of Sister Chromatids; Neutrophil degranulation; ABC-family proteins mediated transport; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "190.6" "173.2" "249.7" "843.8" "345.5" "178.6" "347.6" "199.1" "279.8" "782.8" "602.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "4" "1" "2" "1" "299" "33.6" "4.81" "649.73" "" "1" "" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "28.0" "17.1" "21.6" "93.5" "32.4" "12.1" "20.1" "19.3" "18.2" "15.0" "12.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q71RC2" "La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3" "2" "1" "1" "1" "724" "80.5" "6.61" "639.86" "" "1" "" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383" "113251" "ENSG00000161813" "LARP4" "A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9" "" "" "0" "0" "5.6" "4.8" "11.7" "50.8" "16.9" "3.4" "15.4" "7.3" "8.8" "52.1" "30.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20585" "DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4" "2" "2" "2" "2" "1137" "127.3" "8.02" "624.30" "" "2" "" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05192" "4437" "ENSG00000113318" "MSH3" "A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867" "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2" "Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UQ84" "Exonuclease 1 OS=Homo sapiens OX=9606 GN=EXO1 PE=1 SV=2" "3" "2" "2" "2" "846" "94.0" "8.31" "623.00" "" "2" "" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "9156" "ENSG00000174371" "EXO1" "hsa:9156; O60545; O75214; O75466; Q5T396; Q96IJ1; Q9UG38; Q9UNW0; Q9UQ84" "Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "DNA repair pathways, full network; DNA mismatch repair; Primary ovarian insufficiency" "19" "0" "16.2" "17.0" "17.3" "39.3" "21.7" "25.4" "28.9" "16.1" "18.2" "52.5" "45.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P02768" "Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2" "2" "1" "1" "1" "609" "69.3" "6.28" "606.03" "" "1" "" "stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "213" "ENSG00000163631" "ALB" "E7ESS9; hsa:213; O95574; P02768; P04277; Q13140; Q645G4; Q68DN5; Q6UXK4; Q86YG0; Q8IUK7; Q9P157; Q9P1I7; Q9UHS3; Q9UJZ0" "Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Aspirin ADME; Ciprofloxacin ADME; Recycling of bile acids and salts; Prednisone ADME; Heme degradation; HDL remodeling; Heme biosynthesis" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling" "17" "0" "22.9" "21.9" "20.8" "95.1" "38.5" "24.4" "24.5" "20.5" "20.1" "57.4" "27.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "4" "2" "2" "1" "474" "51.3" "9.41" "558.25" "" "2" "" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IZL8" "Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2" "1" "1" "1" "1" "1130" "119.6" "4.34" "550.73" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08166, Pf08167" "27043" "ENSG00000141456" "PELP1" "hsa:27043; O15450; Q5EGN3; Q6NTE6; Q8IZL8; Q96FT1; Q9BU60" "Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression" "" "2" "0" "4.1" "7.4" "11.5" "37.1" "15.0" "11.2" "34.6" "14.4" "7.0" "41.4" "21.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NUL3" "Double-stranded RNA-binding protein Staufen homolog 2 OS=Homo sapiens OX=9606 GN=STAU2 PE=1 SV=2" "3" "2" "2" "1" "570" "62.6" "9.61" "550.70" "" "2" "" "stress response;transport;developmental processes;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "27067" "ENSG00000040341" "STAU2" "A0A0A0MTC5; B7Z1I6; B7Z292; B7Z8B4; E7ER74; E9PEI3; E9PF26; E9PF50; hsa:27067; Q6AHY7; Q96HM0; Q96HM1; Q9NUL3; Q9NVI5; Q9UGG6" "" "" "0" "0" "8.3" "8.2" "5.9" "25.3" "12.5" "8.3" "14.2" "7.2" "9.6" "24.5" "9.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6PD62" "RNA polymerase-associated protein CTR9 homolog OS=Homo sapiens OX=9606 GN=CTR9 PE=1 SV=1" "2" "2" "2" "2" "1173" "133.4" "6.77" "549.49" "" "2" "" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13181" "9646" "ENSG00000198730" "CTR9" "D3DQV8; hsa:9646; Q15015; Q6PD62" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "6.6" "4.2" "8.5" "44.2" "16.7" "10.5" "17.4" "15.1" "9.4" "67.5" "69.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92686" "Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1" "19" "1" "1" "1" "78" "7.6" "7.87" "546.75" "" "1" "" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00612" "4900" "ENSG00000154146" "NRGN" "hsa:4900; Q92686" "Long-term potentiation" "" "1" "0" "17.4" "11.4" "22.8" "104.2" "38.8" "9.7" "13.2" "11.5" "15.9" "23.5" "19.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q12789" "General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4" "1" "1" "1" "1" "2109" "238.7" "7.30" "540.86" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04182" "2975" "ENSG00000077235" "GTF3C1" "B2RP21; hsa:2975; Q12789; Q12838; Q6DKN9; Q9Y4W9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "10.4" "10.1" "10.5" "33.1" "15.6" "7.9" "21.5" "11.4" "11.7" "42.6" "32.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HBM1" "Kinetochore protein Spc25 OS=Homo sapiens OX=9606 GN=SPC25 PE=1 SV=1" "6" "1" "1" "1" "224" "26.1" "8.00" "536.13" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08234" "57405" "ENSG00000152253; ENSG00000277909" "SPC25" "A8K4X8; D3DPC0; hsa:57405; Q9HBM1" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "12.2" "15.4" "22.1" "73.5" "36.0" "15.9" "25.9" "14.0" "32.5" "59.8" "37.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "5" "1" "1" "1" "228" "26.2" "6.44" "531.87" "" "1" "" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "Small interfering RNA (siRNA) biogenesis" "" "1" "0" "18.0" "14.5" "26.0" "149.6" "52.0" "5.5" "15.3" "26.1" "17.2" "28.1" "25.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62273" "40S ribosomal protein S29 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2" "14" "1" "2" "1" "56" "6.7" "10.13" "525.28" "" "1" "" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00253" "6235" "ENSG00000213741" "RPS29" "A8MZ73; hsa:6235; P30054; P62273" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins; 11p11.2 copy number variation syndrome" "20" "0" "261.0" "288.1" "402.4" "697.7" "417.0" "376.3" "721.6" "316.0" "324.6" "852.6" "366.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "1" "1" "1" "1" "858" "95.7" "5.03" "525.13" "" "1" "" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases" "IL-18 signaling pathway" "3" "0" "39.4" "31.9" "53.6" "231.7" "93.0" "24.0" "71.2" "55.5" "61.2" "77.5" "47.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "1" "1" "1" "1" "930" "103.5" "5.97" "506.87" "" "1" "" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "0" "21.2" "10.9" "17.5" "30.8" "20.8" "12.8" "27.6" "9.4" "15.0" "37.8" "24.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "3" "1" "1" "1" "492" "52.0" "6.48" "479.01" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "tRNA modification in the mitochondrion" "" "1" "0" "5.5" "5.1" "8.9" "41.2" "16.6" "3.8" "6.6" "4.5" "7.7" "14.7" "15.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "2" "1" "1" "1" "736" "82.8" "7.31" "467.51" "" "1" "" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "17.3" "12.6" "16.7" "36.8" "23.2" "9.0" "27.9" "14.0" "20.0" "24.2" "17.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IVW6" "AT-rich interactive domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ARID3B PE=1 SV=2" "3" "1" "1" "1" "561" "60.6" "7.52" "466.39" "" "1" "" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01388" "10620" "ENSG00000179361" "ARID3B" "hsa:10620; O95443; Q59HC9; Q6P9C9; Q8IVW6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "3" "1" "1" "1" "677" "73.3" "4.84" "461.65" "" "1" "" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "10.7" "7.5" "7.3" "30.2" "16.0" "7.6" "9.7" "6.0" "6.1" "13.3" "11.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "3" "1" "1" "1" "370" "40.7" "7.21" "454.90" "" "1" "" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160, Pf13176" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "ESR-mediated signaling" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "4" "0" "21.8" "15.9" "28.9" "108.2" "48.2" "10.4" "48.4" "19.5" "28.7" "57.4" "34.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q2M1P5" "Kinesin-like protein KIF7 OS=Homo sapiens OX=9606 GN=KIF7 PE=1 SV=2" "1" "1" "1" "1" "1343" "150.5" "6.79" "443.82" "" "1" "" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "374654" "ENSG00000166813" "KIF7" "hsa:374654; Q2M1P5; Q3SXY0; Q6UXE9; Q8IW72" "Hedgehog 'on' state; Hedgehog 'off' state" "Hedgehog signaling pathway; Hedgehog signaling pathway; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "6.1" "9.6" "9.1" "23.1" "10.5" "7.3" "15.0" "5.8" "7.0" "23.5" "16.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "3" "1" "1" "1" "444" "49.3" "7.23" "440.03" "" "1" "" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "3.4" "5.7" "5.6" "42.9" "18.0" "6.5" "11.5" "14.9" "6.7" "11.0" "9.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "25" "1" "1" "1" "63" "6.9" "7.24" "433.70" "" "1" "" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Mitochondrial protein import" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "5" "0" "34.4" "31.0" "56.5" "137.3" "69.8" "27.3" "96.6" "22.6" "27.8" "64.7" "24.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "2" "1" "1" "1" "706" "80.2" "6.70" "432.23" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "14.6" "19.7" "22.5" "60.4" "22.5" "11.9" "28.2" "14.1" "26.3" "81.4" "117.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15051" "IQ calmodulin-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=IQCB1 PE=1 SV=1" "2" "1" "1" "1" "598" "68.9" "9.10" "427.22" "" "1" "" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00612" "9657" "ENSG00000173226" "IQCB1" "hsa:9657; Q15051; Q3KS08; Q3KS09; Q5DKQ7; Q8NI79; Q9BS08" "Anchoring of the basal body to the plasma membrane" "Ciliary landscape; Ciliopathies; Bardet-Biedl syndrome" "4" "0" "12.5" "5.9" "16.9" "38.8" "17.4" "6.2" "16.3" "15.2" "17.1" "54.6" "41.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A8K8P3" "Protein SFI1 homolog OS=Homo sapiens OX=9606 GN=SFI1 PE=1 SV=2" "1" "1" "1" "1" "1242" "147.6" "10.81" "421.11" "" "1" "" "" "cytosol;cytoskeleton" "other molecular function" "" "9814" "ENSG00000198089" "SFI1" "A1L373; A1L387; A2A2L2; A8K8P3; B1AKL9; B5MDB7; B7Z1V6; B7Z8G3; B7ZBE2; B7ZBE3; hsa:9814; O60289; Q2TAN8; Q5W1B5; Q86TK0; Q8N4U8; Q8N8C1; Q8WU14" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "7.1" "7.4" "7.7" "27.1" "11.7" "16.3" "116.1" "84.5" "135.5" "393.7" "234.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "5" "1" "1" "1" "183" "20.9" "7.69" "419.80" "" "1" "" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; TGF-beta receptor signaling activates SMADs" "" "5" "0" "34.4" "25.9" "44.8" "136.3" "60.0" "20.2" "39.6" "23.6" "22.3" "43.6" "19.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "3" "1" "1" "1" "411" "43.2" "10.04" "418.82" "" "1" "" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IYA6" "Cytoskeleton-associated protein 2-like OS=Homo sapiens OX=9606 GN=CKAP2L PE=1 SV=4" "1" "1" "1" "1" "745" "83.5" "9.83" "414.65" "" "1" "" "" "cytosol;cytoskeleton" "" "Pf15297" "150468" "ENSG00000169607" "CKAP2L" "A8K915; B4DZE3; B7ZAC6; F5H0M5; hsa:150468; Q53QF8; Q53RS8; Q8IYA6; Q8N1J8" "" "2q13 copy number variation syndrome" "1" "0" "15.8" "14.1" "20.3" "22.5" "26.3" "15.2" "24.6" "11.4" "26.0" "32.3" "10.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=2" "12" "1" "1" "1" "129" "14.7" "4.93" "408.83" "" "1" "" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04419, Pf19026" "100137436; 101127706; 104002286; 104679625; 105491324; 105549422; 105588143; 108521295; 25764; 713266" "ENSCATG00000038565; ENSGGOG00000014809; ENSMFAG00000057677; ENSMLEG00000000898; ENSMMUG00000022768; ENSMNEG00000018318; ENSPANG00000018102; ENSPPAG00000034659; ENSPTEG00000009792; ENSPTEG00000019135; ENSPTRG00000038721; ENSRBIG00000028237; ENSRROG00000039445; ENSTGEG00000007663" "HYPK; LOC113219833" "A0A024R5Q1; A0A1D5R5K3; A0A2I2YQJ1; A0A2J8NTT0; A0A2K5N035; A0A2K5TR12; A0A2K5XAQ0; A0A2K6AXP0; A0A2K6KBN5; A0A2K6QRU2; A0A2R9B6N1; A0A663DGD1; A0A6D2Y1W8; A0A8C9GZF6; A0A8D2ERJ4; A0A8J8XMG0; A9X1C4; F7GC11; G7MX15; G7PB77; H2Q9B3; hsa:25764; mcc:713266; mleu:105549422; mni:105491324; panu:100137436; ptr:104002286; rbb:108521295; rro:104679625" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92551" "Inositol hexakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=IP6K1 PE=1 SV=3" "3" "1" "1" "1" "441" "50.2" "7.24" "406.54" "" "1" "" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "9807" "ENSG00000176095" "IP6K1" "A8K157; A8MUX4; hsa:9807; Q7L3I7; Q92551; Q96E38" "Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus" "" "2" "0" "0.0" "0.0" "2.5" "10.2" "4.7" "5.3" "12.5" "13.7" "15.7" "90.3" "107.7" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BV44" "THUMP domain-containing protein 3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "3" "1" "1" "1" "507" "57.0" "6.37" "393.04" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "4.1" "4.9" "9.2" "50.9" "9.6" "1.2" "8.7" "5.7" "3.2" "26.6" "44.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "2" "1" "1" "1" "738" "80.5" "6.92" "390.06" "" "1" "" "other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q92552" "28S ribosomal protein S27, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "3" "1" "1" "1" "414" "47.6" "6.18" "386.77" "" "1" "" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "50.8" "52.0" "87.2" "329.7" "151.8" "107.6" "161.2" "93.1" "104.5" "272.9" "216.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "1" "1" "1" "1" "919" "101.7" "5.62" "386.29" "" "1" "" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "14" "0" "9.5" "9.5" "12.6" "75.3" "27.6" "3.1" "11.3" "14.1" "8.5" "16.8" "12.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "12" "1" "1" "1" "108" "11.9" "8.16" "381.91" "" "1" "" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Disturbed pathways in Duchenne Muscular Dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "14" "0" "24.2" "26.4" "39.9" "137.4" "49.1" "21.5" "36.8" "37.7" "31.2" "88.9" "75.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "1" "1" "1" "1" "1341" "151.8" "6.43" "380.28" "" "1" "" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "" "2" "0" "66.2" "67.0" "86.1" "327.1" "134.4" "41.0" "91.2" "76.6" "51.3" "180.3" "89.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "4" "1" "1" "1" "328" "35.6" "7.39" "379.67" "" "1" "" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "6.5" "3.6" "10.0" "29.8" "13.3" "4.7" "10.3" "5.4" "7.1" "14.1" "11.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "3" "1" "1" "1" "420" "47.0" "8.73" "374.05" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "rRNA modification in the mitochondrion" "" "1" "0" "45.6" "25.8" "26.7" "61.8" "41.0" "31.2" "53.7" "15.3" "27.7" "80.5" "25.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "4" "1" "1" "1" "412" "46.6" "7.18" "372.35" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "4" "1" "1" "1" "225" "26.0" "5.78" "369.40" "" "1" "" "" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "13.3" "25.2" "29.3" "65.1" "32.0" "19.9" "39.3" "29.8" "25.4" "72.0" "91.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NXX6" "Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2" "2" "1" "1" "1" "385" "44.3" "5.38" "363.71" "" "1" "" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf08743, Pf15412" "54780" "ENSG00000107672" "NSMCE4A" "hsa:54780; Q5SQQ5; Q6P673; Q8WY66; Q9BS90; Q9NXX6" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "132.8" "101.2" "128.0" "223.8" "141.4" "116.4" "201.4" "107.2" "143.2" "386.2" "334.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BRR8" "G patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GPATCH1 PE=1 SV=1" "1" "1" "1" "1" "931" "103.3" "7.05" "357.62" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf07713" "55094" "ENSG00000076650" "GPATCH1" "hsa:55094; Q8IZV6; Q8N3B7; Q9BRR8; Q9NW94" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "2" "1" "1" "1" "457" "51.2" "5.90" "357.40" "" "1" "" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "7" "0" "43.1" "26.1" "38.2" "102.6" "55.9" "29.6" "51.4" "21.3" "27.9" "58.1" "29.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5SY16" "Polynucleotide 5'-hydroxyl-kinase NOL9 OS=Homo sapiens OX=9606 GN=NOL9 PE=1 SV=1" "2" "1" "1" "1" "702" "79.3" "9.13" "348.08" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus" "nucleic acid binding activity;kinase activity;other molecular function" "Pf16575" "79707" "ENSG00000162408" "NOL9" "hsa:79707; Q2NL84; Q4VBY3; Q5SY16; Q6P472; Q7L4D6; Q96EE0; Q9H5L4" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "104.0" "75.6" "104.0" "176.5" "126.2" "90.0" "153.0" "49.5" "82.2" "149.7" "66.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y2R4" "Probable ATP-dependent RNA helicase DDX52 OS=Homo sapiens OX=9606 GN=DDX52 PE=1 SV=3" "2" "1" "1" "1" "599" "67.5" "9.67" "340.74" "" "1" "" "" "" "" "" "" "" "" "" "" "" "0" "0" "5.8" "3.9" "7.4" "33.8" "11.6" "6.0" "10.3" "6.0" "13.1" "58.6" "56.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "4" "1" "1" "1" "261" "28.1" "5.91" "338.91" "" "1" "" "cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; hsa:23558; O95638; Q969T9" "" "" "0" "0" "47.5" "34.6" "50.1" "146.6" "74.5" "30.7" "42.4" "33.0" "41.8" "129.5" "94.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0" "1" "1" "1" "1978" "220.5" "6.38" "334.28" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "Transcriptional regulation of white adipocyte differentiation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "3" "1" "1" "1" "352" "38.4" "9.11" "326.63" "" "1" "" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "" "8" "0" "21.3" "23.7" "28.0" "53.1" "31.5" "17.0" "35.3" "22.4" "32.7" "65.5" "60.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "3" "1" "1" "1" "339" "37.8" "4.97" "321.72" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "Cytosolic iron-sulfur cluster assembly" "2q11.2 copy number variation syndrome" "2" "0" "26.8" "32.0" "45.7" "135.0" "57.7" "31.0" "61.2" "32.6" "37.6" "58.7" "45.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96JC1" "Vam6/Vps39-like protein OS=Homo sapiens OX=9606 GN=VPS39 PE=1 SV=2" "1" "1" "1" "1" "886" "101.7" "6.99" "321.25" "" "1" "" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00780, Pf10366, Pf10367" "23339" "ENSG00000166887" "VPS39" "hsa:23339; O94869; Q71SQ6; Q7Z3V3; Q96B93; Q96JC1; Q96RM0" "SARS-CoV-2 modulates autophagy" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P28288" "ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1" "1" "1" "1" "1" "659" "75.4" "9.36" "320.87" "" "1" "" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00005, Pf06472" "5825" "ENSG00000117528" "ABCD3" "D3DT46; hsa:5825; P28288; Q15271; Q6NUN5; Q96DA3; Q9H529" "RHOC GTPase cycle; RHOA GTPase cycle; Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "Nuclear receptors in lipid metabolism and toxicity; Fragile X syndrome" "6" "0" "83.1" "92.2" "119.2" "412.7" "178.1" "76.6" "139.4" "108.8" "110.0" "375.0" "374.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BX10" "GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=GTPBP2 PE=1 SV=1" "1" "1" "1" "1" "602" "65.7" "8.05" "320.53" "" "1" "" "protein metabolism;other metabolic processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009" "54676" "ENSG00000172432" "GTPBP2" "hsa:54676; Q5T7E8; Q8ND84; Q8TAH7; Q8WUA5; Q9BX10; Q9HCS9; Q9NRU4; Q9NX60" "Platelet degranulation" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "2" "0" "32.7" "24.3" "32.3" "82.0" "32.6" "24.1" "56.2" "34.8" "41.3" "131.8" "137.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P61019" "Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1" "4" "1" "1" "1" "212" "23.5" "6.54" "320.33" "" "1" "" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "5862" "ENSG00000104388" "RAB2A" "B2R5W8; B4DMQ5; hsa:5862; P08886; P61019" "RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "4" "0" "38.9" "42.7" "73.0" "351.7" "141.7" "47.7" "91.4" "57.3" "78.3" "163.5" "128.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8IXI2" "Mitochondrial Rho GTPase 1 OS=Homo sapiens OX=9606 GN=RHOT1 PE=1 SV=2" "2" "1" "1" "1" "618" "70.7" "6.27" "318.96" "" "1" "" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00071, Pf08355, Pf08356" "55288" "ENSG00000126858" "RHOT1" "A4FVB6; A6NFV0; B4DG48; hsa:55288; J9JIH9; Q6NUR3; Q6P9F8; Q6PJG1; Q6YMW8; Q86UB0; Q8IW28; Q8IXI2; Q8IXJ7; Q9H067; Q9H9N8; Q9NUZ2" "Ub-specific processing proteases; RHOT1 GTPase cycle" "" "2" "0" "31.2" "28.5" "42.1" "138.6" "71.2" "39.5" "56.4" "35.7" "38.4" "112.1" "106.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P30519" "Heme oxygenase 2 OS=Homo sapiens OX=9606 GN=HMOX2 PE=1 SV=2" "3" "1" "1" "1" "316" "36.0" "5.41" "316.29" "" "1" "" "other metabolic processes;stress response" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01126" "3163" "ENSG00000103415; ENSG00000277424" "HMOX2" "A8MT35; D3DUD5; hsa:3163; I3L430; O60605; P30519" "Neutrophil degranulation; RHOA GTPase cycle; Cytoprotection by HMOX1; Iron uptake and transport; Heme degradation" "" "5" "0" "18.3" "17.0" "26.6" "98.9" "35.8" "10.2" "19.1" "15.2" "14.4" "22.8" "19.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q13425" "Beta-2-syntrophin OS=Homo sapiens OX=9606 GN=SNTB2 PE=1 SV=1" "2" "1" "1" "1" "540" "57.9" "8.82" "314.39" "" "1" "" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00595, Pf18012" "6645" "ENSG00000168807" "SNTB2" "hsa:6645; Q13425; Q9BY09" "" "" "0" "0" "3.6" "6.4" "6.7" "39.9" "11.7" "6.3" "10.0" "9.2" "6.3" "27.7" "32.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5BJF6" "Outer dense fiber protein 2 OS=Homo sapiens OX=9606 GN=ODF2 PE=1 SV=1" "2" "1" "1" "1" "829" "95.3" "7.62" "314.13" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "4957" "ENSG00000136811" "ODF2" "B1AND3; B4DRK4; B4DX73; B4DZ02; E7EWL2; F5H6J4; hsa:4957; O14721; O60631; Q1W2J6; Q5BJF6; Q6UN26; Q7Z5I6; Q96FN2" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "2" "1" "1" "1" "480" "54.4" "6.61" "300.21" "" "1" "" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "MHC class II antigen presentation; Glycosphingolipid metabolism; Neutrophil degranulation; Sialic acid metabolism; Defective NEU1 causes sialidosis" "Ciliary landscape" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "Q6P161" "39S ribosomal protein L54, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "7" "1" "1" "1" "138" "15.8" "9.60" "297.65" "" "1" "" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "62.1" "62.1" "72.7" "202.1" "92.1" "55.2" "99.6" "51.1" "69.3" "198.1" "197.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "3" "1" "1" "1" "206" "22.2" "9.38" "295.73" "" "1" "" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "" "Orexin receptor pathway" "1" "0" "65.9" "68.8" "72.6" "446.1" "129.6" "48.5" "91.0" "83.7" "84.9" "350.8" "241.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15386" "Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3" "1" "1" "1" "1" "1083" "123.8" "6.71" "292.86" "" "1" "" "protein metabolism;other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf00632" "9690" "ENSG00000009335" "UBE3C" "A4D235; A6NCP3; hsa:9690; Q15386; Q8TC15; Q96CR4; Q9UDU3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "21.3" "24.0" "36.2" "80.4" "52.7" "30.5" "54.2" "39.3" "41.5" "73.1" "64.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q17RS7" "Flap endonuclease GEN homolog 1 OS=Homo sapiens OX=9606 GN=GEN1 PE=1 SV=2" "1" "1" "1" "1" "908" "102.8" "7.81" "291.12" "" "1" "" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867, Pf18704" "348654" "ENSG00000178295" "GEN1" "hsa:348654; Q17RS7; Q17RS9; Q6ZN37" "Resolution of D-loop Structures through Holliday Junction Intermediates" "" "1" "0" "9.5" "15.7" "17.0" "38.4" "21.2" "16.8" "25.6" "14.3" "21.5" "52.3" "54.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "6" "1" "1" "1" "172" "19.8" "4.84" "288.80" "" "1" "" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13405" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "1" "1" "1" "1" "583" "66.7" "5.11" "283.92" "" "1" "" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q05209" "Tyrosine-protein phosphatase non-receptor type 12 OS=Homo sapiens OX=9606 GN=PTPN12 PE=1 SV=3" "2" "1" "1" "1" "780" "88.1" "5.62" "281.75" "" "1" "" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5782" "ENSG00000127947" "PTPN12" "A4D1C5; B4DKY2; E9PBR5; E9PEH9; hsa:5782; Q05209; Q16130; Q59FD6; Q75MN8; Q86XU4" "Signaling by PDGF; SHC1 events in ERBB2 signaling; Downregulation of ERBB2 signaling; EGFR downregulation; Interleukin-37 signaling; Constitutive Signaling by Overexpressed ERBB2" "EGF/EGFR signaling pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "n/a" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H936" "Mitochondrial glutamate carrier 1 OS=Homo sapiens OX=9606 GN=SLC25A22 PE=1 SV=1" "2" "1" "1" "1" "323" "34.4" "9.29" "280.40" "" "1" "" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf00153" "79751" "ENSG00000177542" "SLC25A22" "A8K366; C9J1H6; E9PJD3; E9PKB2; E9PL68; E9PN26; E9PNQ3; E9PP01; E9PR97; hsa:79751; Q8TBU8; Q9H936" "Organic anion transporters" "" "1" "0" "21.6" "20.5" "20.4" "116.6" "41.0" "13.4" "25.8" "25.5" "28.8" "165.0" "242.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4J8" "Dystrobrevin alpha OS=Homo sapiens OX=9606 GN=DTNA PE=1 SV=2" "1" "1" "1" "1" "743" "83.8" "6.89" "279.63" "" "1" "" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00569, Pf09068, Pf09069" "1837" "ENSG00000134769" "DTNA" "A8K541; A8MSZ0; A8MUY4; B4DGS6; B4DIR0; B4DIU8; hsa:1837; M0QYX6; M0R397; O15332; O15333; O75697; Q13197; Q13198; Q13199; Q13498; Q13499; Q13500; Q59GK7; Q9BS59; Q9Y4J8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0" "1" "1" "1" "2799" "309.2" "5.85" "279.35" "" "1" "" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "" "Mesodermal commitment pathway" "1" "0" "69.2" "81.2" "90.0" "176.1" "100.9" "64.6" "171.4" "89.5" "82.1" "253.1" "201.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q99576" "TSC22 domain family protein 3 OS=Homo sapiens OX=9606 GN=TSC22D3 PE=1 SV=2" "7" "1" "1" "1" "134" "14.8" "4.54" "278.74" "" "1" "" "stress response;other biological processes" "cytosol;nucleus" "" "Pf01166" "1831" "ENSG00000157514" "TSC22D3" "hsa:1831; Q5H9S3; Q5JRI9; Q5JRJ2; Q6FIH6; Q8NAI1; Q8WVB9; Q99576; Q9UBN5; Q9UG13" "Stimuli-sensing channels" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "3" "0" "16.0" "13.5" "26.3" "129.9" "28.5" "11.7" "25.8" "19.2" "24.2" "109.1" "81.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z6R9" "Transcription factor AP-2-delta OS=Homo sapiens OX=9606 GN=TFAP2D PE=1 SV=1" "2" "1" "1" "1" "452" "49.5" "8.16" "277.93" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03299" "83741" "ENSG00000008197" "TFAP2D" "hsa:83741; Q7Z6R9; Q8IWX0" "Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Activation of the TFAP2 (AP-2) family of transcription factors" "Ciliary landscape" "3" "0" "1054.7" "826.8" "373.0" "142.6" "91.1" "90.4" "218.8" "61.8" "118.6" "217.5" "125.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "3" "1" "1" "1" "495" "55.5" "8.27" "277.87" "" "1" "" "RNA metabolism OR transcription;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "9.5" "7.4" "11.2" "16.3" "10.3" "7.9" "17.9" "7.3" "6.0" "17.5" "16.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6ZN17" "Protein lin-28 homolog B OS=Homo sapiens OX=9606 GN=LIN28B PE=1 SV=1" "3" "1" "1" "1" "250" "27.1" "8.91" "274.02" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf00313" "389421" "ENSG00000187772" "LIN28B" "A1L165; B2RPN6; hsa:389421; Q5TCM4; Q6ZN17" "" "Cardiac progenitor differentiation; Hippo-Merlin signaling dysregulation; Pleural mesothelioma; CCL18 signaling pathway" "4" "0" "152.5" "101.7" "136.7" "277.5" "152.3" "108.3" "208.4" "74.5" "92.7" "207.4" "98.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "4" "1" "1" "1" "291" "32.5" "9.14" "271.07" "" "1" "" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "Phase I - Functionalization of compounds" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "2" "1" "1" "1" "385" "42.2" "5.66" "270.64" "" "1" "" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Degradation of the extracellular matrix; Integrin cell surface interactions; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "10" "0" "81.8" "79.3" "116.4" "442.3" "180.0" "80.9" "128.3" "71.7" "101.4" "237.0" "182.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "3" "1" "1" "1" "470" "52.9" "7.46" "270.05" "" "1" "" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "High" "High" "n/a" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q6ZW49" "PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2" "1" "1" "1" "1" "1069" "121.3" "6.70" "267.71" "" "1" "" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf00533, Pf12738" "22976" "ENSG00000157212" "PAXIP1" "hsa:22976; O15404; Q6N099; Q6ZW49; Q6ZWH9; Q7Z315; Q86UN0; Q8N4P9; Q96HP2" "Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of WDR5-containing histone-modifying complexes" "16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Kleefstra syndrome" "6" "0" "3.7" "0.0" "11.5" "28.7" "10.8" "5.0" "9.5" "5.9" "10.3" "16.2" "14.4" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O00423" "Echinoderm microtubule-associated protein-like 1 OS=Homo sapiens OX=9606 GN=EML1 PE=1 SV=3" "1" "1" "1" "1" "815" "89.8" "7.06" "265.82" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "2009" "ENSG00000066629" "EML1" "hsa:2009; O00423; Q86U15; Q8N536; Q8N5C4; Q8WWL6" "" "" "0" "0" "62.3" "52.6" "75.7" "152.4" "78.0" "60.1" "113.0" "80.2" "114.1" "322.5" "390.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "2" "1" "1" "1" "421" "44.9" "7.52" "265.80" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "22q11.2 copy number variation syndrome" "4" "0" "49.1" "56.6" "84.8" "229.2" "104.4" "49.8" "93.5" "63.6" "80.2" "319.6" "643.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "1" "1" "1" "1" "822" "91.9" "6.65" "264.78" "" "1" "" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "3" "1" "1" "1" "403" "43.8" "5.78" "262.76" "" "1" "" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "8.2" "11.5" "14.7" "36.2" "17.9" "11.7" "21.2" "12.8" "14.7" "27.8" "18.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBV7" "Beta-1,4-galactosyltransferase 7 OS=Homo sapiens OX=9606 GN=B4GALT7 PE=1 SV=1" "2" "1" "1" "1" "327" "37.4" "8.98" "262.67" "" "1" "" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf02709, Pf13733" "11285" "ENSG00000027847" "B4GALT7" "B3KN39; hsa:11285; Q9UBV7; Q9UHN2" "A tetrasaccharide linker sequence is required for GAG synthesis; Defective B4GALT7 causes EDS, progeroid type" "Proteoglycan biosynthesis" "3" "0" "2.8" "0.0" "4.2" "15.9" "6.7" "1.8" "7.2" "2.3" "4.0" "35.6" "36.6" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NX07" "tRNA selenocysteine 1-associated protein 1 OS=Homo sapiens OX=9606 GN=TRNAU1AP PE=1 SV=1" "2" "1" "1" "1" "287" "32.5" "4.74" "262.08" "" "1" "" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf17654" "54952" "ENSG00000180098" "TRNAU1AP" "hsa:54952; Q86SU7; Q9NX07" "" "" "0" "0" "20.4" "24.5" "20.9" "80.5" "32.1" "16.4" "35.3" "14.1" "25.6" "50.9" "38.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "3" "1" "1" "1" "471" "51.5" "5.73" "261.94" "" "1" "" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "0" "23.1" "19.2" "30.2" "50.2" "30.1" "14.5" "30.7" "14.3" "20.8" "34.2" "17.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "2" "1" "1" "1" "592" "67.3" "5.92" "261.05" "" "1" "" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "Ras signaling" "6" "0" "8.9" "8.6" "10.0" "29.2" "11.7" "5.7" "16.2" "7.5" "7.2" "35.7" "21.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBX3" "Mitochondrial dicarboxylate carrier OS=Homo sapiens OX=9606 GN=SLC25A10 PE=1 SV=2" "4" "1" "1" "1" "287" "31.3" "9.54" "258.44" "" "1" "" "other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "transporter activity" "Pf00153" "1468" "ENSG00000183048" "SLC25A10" "hsa:1468; Q542Z3; Q96BA1; Q96IP1; Q9UBX3" "Gluconeogenesis; Sulfide oxidation to sulfate; Organic anion transporters" "" "3" "0" "7.5" "12.5" "14.0" "22.2" "14.9" "8.1" "20.3" "11.6" "10.5" "33.5" "20.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "2" "1" "1" "1" "382" "43.9" "7.46" "258.39" "" "1" "" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "27.2" "28.4" "53.5" "150.8" "65.7" "30.1" "95.8" "30.1" "58.8" "112.8" "81.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5TG30" "Rho GTPase-activating protein 40 OS=Homo sapiens OX=9606 GN=ARHGAP40 PE=3 SV=3" "1" "1" "1" "1" "622" "68.9" "7.84" "256.80" "" "1" "" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "" "ENSG00000124143" "ARHGAP40" "Q5TG30" "RHOA GTPase cycle; CDC42 GTPase cycle" "" "2" "0" "19.1" "16.6" "32.8" "72.8" "37.3" "20.6" "34.9" "17.0" "6.2" "437.8" "1362.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P15291" "Beta-1,4-galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GALT1 PE=1 SV=5" "2" "1" "1" "1" "398" "43.9" "8.65" "256.76" "" "1" "" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02709, Pf13733" "2683" "ENSG00000086062" "B4GALT1" "B2R710; D3DRL2; hsa:2683; P15291; Q12909; Q12910; Q12911; Q14456; Q14509; Q14523" "Neutrophil degranulation; Pre-NOTCH Processing in Golgi; N-Glycan antennae elongation; Keratan sulfate biosynthesis; Interaction With Cumulus Cells And The Zona Pellucida; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d); Lactose synthesis; Defective B4GALT1 causes CDG-2d" "Metabolism of sphingolipids in ER and Golgi apparatus; N-glycan biosynthesis; Synthesis of ceramides and 1-deoxyceramides" "11" "0" "9.9" "7.3" "10.0" "47.7" "14.8" "7.4" "12.1" "10.1" "11.4" "21.1" "28.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "3" "1" "1" "1" "307" "33.9" "6.29" "256.31" "" "1" "" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "61.9" "59.2" "82.4" "309.1" "112.2" "53.2" "111.4" "71.8" "71.7" "203.3" "171.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "2" "1" "1" "1" "871" "97.6" "5.81" "256.09" "" "1" "" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "O60244" "Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2" "0" "1" "1" "1" "1454" "160.5" "8.73" "256.05" "" "1" "" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08638" "9282" "ENSG00000180182" "MED14" "hsa:9282; O60244; Q4KMR7; Q9UNB3" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway" "Vitamin D in inflammatory diseases" "4" "0" "25.4" "28.3" "52.1" "294.7" "89.4" "18.8" "50.7" "41.1" "39.5" "115.6" "109.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0" "1" "1" "1" "1298" "146.5" "7.01" "255.91" "" "1" "" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "4" "0" "69.0" "62.1" "85.9" "428.8" "154.0" "39.0" "100.4" "74.5" "90.4" "165.7" "138.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969F9" "Hermansky-Pudlak syndrome 3 protein OS=Homo sapiens OX=9606 GN=HPS3 PE=1 SV=1" "1" "1" "1" "1" "1004" "113.7" "6.43" "255.26" "" "1" "" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle;other cell component" "" "Pf14761, Pf14762, Pf14763" "84343" "ENSG00000163755" "HPS3" "A8K6G6; hsa:84343; Q8WTV6; Q969F9; Q96AP1; Q96MR3; Q9H608" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "1" "1" "1" "1" "528" "60.6" "5.06" "254.21" "" "1" "" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "54.7" "52.7" "111.3" "442.9" "158.4" "20.7" "122.2" "94.5" "88.4" "241.3" "217.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q08426" "Peroxisomal bifunctional enzyme OS=Homo sapiens OX=9606 GN=EHHADH PE=1 SV=3" "2" "1" "1" "1" "723" "79.4" "9.14" "253.82" "" "1" "" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00378, Pf00725, Pf02737" "1962" "ENSG00000113790" "EHHADH" "A8K6Y3; B4DWG3; D3DNU0; hsa:1962; Q08426; Q58EZ5" "Peroxisomal protein import; Beta-oxidation of very long chain fatty acids" "Constitutive androstane receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Mitochondrial fatty acid oxidation disorders" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "1" "" "False" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "6" "1" "1" "1" "118" "12.9" "5.52" "253.68" "" "1" "" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "60.2" "55.4" "83.7" "350.0" "133.1" "65.5" "132.8" "80.2" "92.3" "261.0" "213.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8N7H5" "RNA polymerase II-associated factor 1 homolog OS=Homo sapiens OX=9606 GN=PAF1 PE=1 SV=2" "1" "1" "1" "1" "531" "59.9" "4.63" "253.59" "" "1" "" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03985" "54623" "ENSG00000006712" "PAF1" "hsa:54623; M0QX35; O75239; Q8N7H5; Q9H166; Q9NUU9" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "35.2" "31.7" "32.9" "77.6" "51.6" "37.4" "62.7" "26.6" "33.2" "81.5" "69.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0" "1" "1" "1" "2426" "263.7" "5.64" "253.43" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "71.6" "54.3" "91.0" "205.8" "116.5" "57.7" "117.8" "51.5" "107.0" "553.1" "515.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "2" "1" "1" "1" "377" "41.9" "6.65" "253.22" "" "1" "" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "43.8" "51.0" "61.6" "325.0" "101.7" "17.1" "41.8" "50.7" "42.1" "133.8" "78.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "1" "1" "1" "1" "1192" "132.5" "6.19" "252.60" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "Post-chaperonin tubulin folding pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "1" "1" "1" "1" "666" "73.1" "5.59" "252.50" "" "1" "" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "TYROBP causal network in microglia" "11" "0" "215.6" "147.5" "201.2" "280.3" "242.9" "186.9" "233.0" "138.5" "192.6" "259.5" "167.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "1" "1" "1" "1" "733" "81.7" "7.88" "252.42" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "87.1" "88.7" "109.6" "256.8" "130.7" "74.8" "156.3" "73.4" "79.0" "241.8" "135.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "2" "1" "1" "1" "356" "40.5" "8.34" "252.11" "" "1" "" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "PCNA-Dependent Long Patch Base Excision Repair; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "28.7" "27.9" "36.8" "106.7" "50.6" "33.3" "54.4" "39.7" "75.5" "312.9" "338.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P51970" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Homo sapiens OX=9606 GN=NDUFA8 PE=1 SV=3" "3" "1" "1" "1" "172" "20.1" "7.65" "252.03" "" "1" "" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf06747" "4702" "ENSG00000119421" "NDUFA8" "B1AM93; hsa:4702; P51970; Q9Y6N0" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "74.2" "87.9" "102.0" "312.9" "144.8" "75.4" "138.5" "96.4" "93.7" "246.7" "241.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60522" "Tudor domain-containing protein 6 OS=Homo sapiens OX=9606 GN=TDRD6 PE=2 SV=2" "0" "1" "1" "1" "2096" "236.4" "5.25" "251.96" "" "1" "" "other biological processes" "other cell component" "" "Pf00567" "221400" "ENSG00000180113" "TDRD6" "B3KWU2; F5H5M3; hsa:221400; O60522; Q5HYB1; Q5VTS4; Q6ZMX5" "PIWI-interacting RNA (piRNA) biogenesis" "" "1" "0" "63.4" "48.8" "61.5" "101.8" "84.0" "48.2" "77.1" "51.1" "55.9" "89.7" "64.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "1" "1" "1" "1" "737" "83.7" "6.18" "251.92" "" "1" "" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "12" "0" "24.9" "19.9" "34.2" "95.2" "46.6" "23.1" "50.4" "30.1" "34.9" "106.4" "82.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "2" "1" "1" "1" "369" "39.1" "6.30" "251.80" "" "1" "" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "124.9" "117.5" "147.9" "440.6" "184.8" "75.8" "158.0" "125.7" "146.7" "338.3" "335.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NXC5" "GATOR complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "1" "1" "1" "1" "875" "98.5" "6.73" "251.55" "" "1" "" "stress response;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf17034" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "Amino acids regulate mTORC1" "" "1" "0" "17.8" "21.8" "23.7" "41.1" "30.8" "21.3" "42.6" "18.9" "24.3" "81.2" "75.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q86UD5" "Sodium/hydrogen exchanger 9B2 OS=Homo sapiens OX=9606 GN=SLC9B2 PE=1 SV=2" "1" "1" "1" "1" "537" "57.5" "6.71" "251.14" "" "1" "" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf00999" "133308" "ENSG00000164038" "SLC9B2" "B5ME52; hsa:133308; Q6ZMD8; Q86UD5; Q96D95" "Stimuli-sensing channels" "" "1" "0" "56.9" "59.0" "85.0" "256.2" "101.4" "55.7" "146.4" "66.8" "74.4" "1126.4" "1468.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q3B7T1" "Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1" "0" "1" "1" "1" "1238" "138.4" "6.33" "250.96" "" "1" "" "other biological processes" "nucleus" "" "" "26098" "ENSG00000107938" "EDRF1" "B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4" "" "" "0" "0" "35.5" "32.5" "38.3" "109.8" "48.2" "29.5" "52.3" "32.6" "34.2" "130.7" "155.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0" "1" "1" "1" "1401" "157.1" "6.61" "249.11" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "Condensation of Prometaphase Chromosomes" "" "1" "0" "21.7" "18.6" "34.8" "175.3" "44.4" "20.2" "58.9" "33.6" "38.5" "131.6" "99.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P1Z9" "Coiled-coil domain-containing protein 180 OS=Homo sapiens OX=9606 GN=CCDC180 PE=2 SV=3" "0" "1" "1" "1" "1701" "197.2" "6.04" "248.91" "" "1" "" "" "" "" "Pf14643, Pf14644" "100499483" "" "CCDC180" "hsa:100499483; Q2KHR6; Q5VV25; Q68DP5; Q69YV9; Q6AHY0; Q9P1Z9" "" "" "0" "0" "140.3" "147.2" "174.7" "392.8" "195.0" "130.2" "329.0" "143.2" "208.2" "571.9" "349.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NZJ4" "Sacsin OS=Homo sapiens OX=9606 GN=SACS PE=1 SV=2" "0" "1" "1" "1" "4579" "520.8" "7.05" "247.77" "" "1" "" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00240, Pf05168" "26278" "ENSG00000151835" "SACS" "hsa:26278; O94835; Q5T9J5; Q5T9J7; Q5T9J8; Q68DF5; Q6MZR4; Q8NBF9; Q9NZJ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "3" "1" "1" "1" "325" "34.3" "8.54" "247.44" "" "1" "" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Peroxisomal protein import; Synthesis of Ketone Bodies" "Amino acid metabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96AB3" "Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1" "5" "1" "1" "1" "205" "22.3" "7.77" "247.01" "" "1" "" "other biological processes" "nucleus;other cell component" "" "Pf00857" "79763" "ENSG00000063241" "ISOC2" "hsa:79763; Q6ZN91; Q96AB3; Q9H5G0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H2P0" "Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1" "1" "1" "1" "1" "1102" "123.5" "7.34" "246.25" "" "1" "" "cell organization and biogenesis;RNA metabolism OR transcription;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00046, Pf19627" "23394" "ENSG00000101126" "ADNP" "E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34" "" "" "0" "0" "88.9" "78.0" "92.1" "200.6" "133.9" "91.0" "162.3" "157.7" "306.6" "1145.7" "1141.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "3" "1" "1" "1" "277" "32.0" "8.66" "245.53" "" "1" "" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Purine salvage" "Genetic causes of porto-sinusoidal vascular disease" "2" "0" "19.9" "24.3" "40.1" "172.8" "66.1" "16.6" "35.9" "33.7" "27.6" "61.7" "63.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H875" "PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1" "5" "1" "1" "1" "184" "21.0" "9.79" "245.05" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06658" "79706" "ENSG00000128563" "PRKRIP1" "B4DGM2; hsa:79706; Q8NDM6; Q96CF8; Q9H875" "mRNA Splicing - Major Pathway" "" "1" "0" "25.4" "17.1" "25.3" "44.6" "33.2" "23.5" "31.4" "16.9" "16.9" "39.4" "27.2" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BQ70" "Transcription factor 25 OS=Homo sapiens OX=9606 GN=TCF25 PE=1 SV=1" "3" "1" "1" "1" "676" "76.6" "6.35" "244.76" "" "1" "" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04910" "22980" "ENSG00000141002" "TCF25" "hsa:22980; Q2MK75; Q9BQ70; Q9UPV3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "n/a" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q68CZ6" "HAUS augmin-like complex subunit 3 OS=Homo sapiens OX=9606 GN=HAUS3 PE=1 SV=1" "2" "1" "1" "1" "603" "69.6" "5.55" "244.57" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf14932" "79441" "ENSG00000214367" "HAUS3" "B4DF64; hsa:79441; O43606; Q68CZ6; Q8TAZ5; Q9BTJ9" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "n/a" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "3" "1" "1" "1" "364" "40.7" "8.88" "243.87" "" "1" "" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "1" "1" "1" "1" "917" "102.3" "6.05" "241.96" "" "1" "" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Glycolysis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; A network map of Macrophage-stimulating protein (MSP) signaling; UDP-derived sugars synthesis in fibroblasts" "5" "0" "9.9" "9.6" "20.0" "76.1" "33.1" "13.5" "39.3" "23.1" "21.9" "120.8" "192.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96NB2" "Sideroflexin-2 OS=Homo sapiens OX=9606 GN=SFXN2 PE=1 SV=2" "4" "1" "1" "1" "322" "36.2" "9.41" "241.88" "" "1" "" "transport" "other membranes;mitochondrion" "transporter activity" "Pf03820" "118980" "ENSG00000156398" "SFXN2" "hsa:118980; Q5JSM6; Q96NB2" "" "" "0" "0" "11.2" "11.3" "16.9" "55.9" "25.3" "12.8" "24.0" "19.8" "19.1" "65.3" "52.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NVH1" "DnaJ homolog subfamily C member 11 OS=Homo sapiens OX=9606 GN=DNAJC11 PE=1 SV=2" "2" "1" "1" "1" "559" "63.2" "8.40" "241.86" "" "1" "" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf00226, Pf11875" "55735" "ENSG00000007923" "DNAJC11" "hsa:55735; Q4VWF5; Q5VZN0; Q6PK20; Q6PK70; Q8NDM2; Q96CL7; Q9NVH1" "Cristae formation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "3" "1" "1" "1" "561" "64.9" "6.14" "240.55" "" "1" "" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "" "3" "0" "6.6" "4.4" "12.6" "39.1" "16.1" "6.7" "15.2" "10.6" "15.2" "101.5" "170.6" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "1" "1" "1" "1" "708" "76.5" "5.07" "240.31" "" "1" "" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "" "2" "0" "182.5" "141.4" "136.9" "247.4" "164.4" "119.6" "157.5" "99.9" "190.7" "239.9" "93.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UJX4" "Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2" "2" "1" "1" "1" "755" "85.0" "6.87" "240.27" "" "1" "" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf12862" "51433" "ENSG00000089053" "ANAPC5" "E9PFB2; hsa:51433; Q8N4H7; Q9BQD4; Q9UJX4" "Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "High" "High" "High" "High" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14976" "Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2" "1" "1" "1" "1" "1311" "143.1" "5.73" "239.75" "" "1" "" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf10409" "2580" "ENSG00000178950" "GAK" "hsa:2580; O14976; Q5U4P5; Q9BVY6" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9H582" "Zinc finger protein 644 OS=Homo sapiens OX=9606 GN=ZNF644 PE=1 SV=2" "1" "1" "1" "1" "1327" "149.5" "8.16" "236.92" "" "1" "" "RNA metabolism OR transcription;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "84146" "ENSG00000122482" "ZNF644" "A2RU71; hsa:84146; Q2TAM0; Q5TCC0; Q6BEP7; Q6P446; Q6PI06; Q7LG67; Q9H582; Q9ULJ9" "" "" "0" "0" "8.5" "6.5" "8.5" "28.6" "15.5" "9.3" "14.1" "7.8" "8.7" "40.8" "26.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15439" "Multidrug resistance-associated protein 4 OS=Homo sapiens OX=9606 GN=ABCC4 PE=1 SV=3" "1" "1" "1" "1" "1325" "149.4" "8.19" "236.60" "" "1" "" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;ER/Golgi;nucleus" "transporter activity;other molecular function" "Pf00005, Pf00664" "10257" "ENSG00000125257" "ABCC4" "A9Z1Z7; B7Z3Q7; hsa:10257; O15439; Q8IVZ4; Q8IZN6; Q8NEW8; Q9Y6J2" "ABC-family proteins mediated transport; Paracetamol ADME; Platelet degranulation ; Azathioprine ADME" "Fluoropyrimidine activity; Androgen receptor network in prostate cancer; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15695" "Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 OS=Homo sapiens OX=9606 GN=ZRSR2P1 PE=5 SV=2" "1" "1" "1" "1" "479" "57.6" "9.36" "236.17" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "" "" "ZRSR2P1" "B2R901; Q13570; Q15695; Q2M3R8" "" "" "0" "0" "77.2" "73.9" "73.9" "99.4" "72.2" "66.6" "120.3" "54.5" "51.6" "94.9" "57.1" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "2" "1" "1" "1" "445" "48.1" "7.12" "236.08" "" "1" "" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "2q37 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "n/a" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O43909" "Exostosin-like 3 OS=Homo sapiens OX=9606 GN=EXTL3 PE=1 SV=1" "1" "1" "1" "1" "919" "104.7" "6.51" "234.84" "" "1" "" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf03016, Pf09258" "2137" "ENSG00000012232" "EXTL3" "D3DST8; hsa:2137; O00225; O43909; Q53XT3" "XBP1(S) activates chaperone genes" "Proteoglycan biosynthesis" "2" "0" "64.1" "55.9" "82.6" "186.2" "84.4" "38.2" "100.9" "53.3" "88.6" "449.7" "597.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "1" "1" "1" "1" "524" "59.0" "7.34" "234.70" "" "1" "" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "336.9" "216.0" "286.3" "338.1" "299.3" "259.8" "300.8" "119.2" "223.2" "340.7" "196.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O60759" "Cytohesin-interacting protein OS=Homo sapiens OX=9606 GN=CYTIP PE=1 SV=2" "2" "1" "1" "1" "359" "40.0" "6.99" "234.49" "" "1" "" "other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00595" "9595" "ENSG00000115165" "CYTIP" "B4DWH9; hsa:9595; O60759; Q15630; Q8NE32" "" "Amplification and expansion of oncogenic pathways as metastatic traits" "1" "0" "43.8" "41.8" "60.7" "198.6" "94.2" "34.9" "62.1" "44.4" "46.3" "111.8" "58.5" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "1" "1" "1" "1" "1046" "116.9" "6.70" "234.45" "" "1" "" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "8" "0" "40.0" "54.8" "59.9" "177.8" "87.4" "49.9" "89.4" "47.1" "45.2" "212.1" "138.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "1" "1" "1" "1" "544" "61.5" "5.47" "234.43" "" "1" "" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "120.4" "96.2" "155.6" "541.6" "228.2" "115.9" "200.7" "116.8" "115.4" "435.2" "361.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9NYW6" "Taste receptor type 2 member 3 OS=Homo sapiens OX=9606 GN=TAS2R3 PE=2 SV=3" "3" "1" "1" "1" "316" "35.9" "9.67" "234.37" "" "1" "" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf05296" "50831" "ENSG00000127362" "TAS2R3" "A4D1U2; hsa:50831; Q645W2; Q75MV6; Q9NYW6" "G alpha (i) signalling events; Sensory perception of sweet, bitter, and umami (glutamate) taste; Class C/3 (Metabotropic glutamate/pheromone receptors)" "" "3" "0" "76.7" "66.6" "72.5" "81.8" "79.1" "64.9" "75.3" "56.1" "70.0" "86.6" "62.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q7Z2D5" "Phospholipid phosphatase-related protein type 4 OS=Homo sapiens OX=9606 GN=PLPPR4 PE=1 SV=1" "1" "1" "1" "1" "763" "82.9" "8.73" "234.15" "" "1" "" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01569" "9890" "ENSG00000117600" "PLPPR4" "E7EPS1; hsa:9890; O75043; Q5T9R9; Q7Z2D5; Q86XQ5; Q8N3F1; Q96MP0" "Lysosphingolipid and LPA receptors" "" "1" "0" "309.3" "406.7" "161.8" "113.3" "100.7" "88.0" "127.0" "57.8" "102.7" "273.5" "216.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "3" "1" "1" "1" "173" "18.8" "6.68" "233.64" "" "1" "" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "XBP1(S) activates chaperone genes" "" "1" "0" "121.0" "151.7" "242.8" "1194.7" "363.4" "42.9" "125.3" "168.5" "104.7" "166.4" "193.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q5VSY0" "G kinase-anchoring protein 1 OS=Homo sapiens OX=9606 GN=GKAP1 PE=1 SV=2" "2" "1" "1" "1" "366" "42.1" "8.82" "233.60" "" "1" "" "signal transduction;other biological processes" "ER/Golgi" "other molecular function" "" "80318" "ENSG00000165113" "GKAP1" "hsa:80318; Q5VSY0; Q96LI0; Q9BYI1; Q9BYI2; Q9H225" "" "" "0" "0" "8.8" "3.9" "5.6" "32.5" "7.0" "7.1" "18.8" "31.7" "8.4" "149.9" "18.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "P17568" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFB7 PE=1 SV=4" "4" "1" "1" "1" "137" "16.4" "8.92" "233.36" "" "1" "" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05676" "4713" "ENSG00000099795" "NDUFB7" "hsa:4713; P17568; Q6ICN9; Q9UI16" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "49.4" "53.0" "66.6" "178.4" "76.8" "44.7" "63.1" "58.2" "60.9" "160.5" "136.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "A4D1E1" "Zinc finger protein 804B OS=Homo sapiens OX=9606 GN=ZNF804B PE=2 SV=2" "0" "1" "1" "1" "1349" "152.5" "8.54" "233.17" "" "1" "" "" "nucleus" "other molecular function" "Pf12171" "219578" "ENSG00000182348" "ZNF804B" "A4D1E1; B2RTV2; hsa:219578; Q7Z714; Q96MN7" "Generic Transcription Pathway" "" "1" "0" "14.3" "14.7" "18.4" "77.1" "19.8" "12.2" "18.5" "14.7" "15.8" "104.0" "88.8" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TER5" "Rho guanine nucleotide exchange factor 40 OS=Homo sapiens OX=9606 GN=ARHGEF40 PE=1 SV=3" "0" "1" "1" "1" "1519" "164.6" "6.15" "232.08" "" "1" "" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf00621" "55701" "ENSG00000165801" "ARHGEF40" "A5PL07; hsa:55701; Q8TER5; Q9BWP5; Q9H7L6; Q9NTF9; Q9NW24" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "" "4" "0" "11.4" "9.1" "9.9" "31.1" "14.7" "8.1" "15.7" "14.2" "27.1" "109.6" "103.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9HAU4" "E3 ubiquitin-protein ligase SMURF2 OS=Homo sapiens OX=9606 GN=SMURF2 PE=1 SV=1" "1" "1" "1" "1" "748" "86.1" "7.96" "231.96" "" "1" "" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00397, Pf00632" "64750" "ENSG00000108854" "SMURF2" "hsa:64750; Q52LL1; Q9H260; Q9HAU4" "Antigen processing: Ubiquitination & Proteasome degradation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Signaling by BMP; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Hedgehog signaling pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "n/a" "n/a" "n/a" "n/a" "High" "High" "n/a" "n/a" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "4" "1" "1" "1" "166" "19.2" "7.34" "231.95" "" "1" "" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "mRNA Splicing - Major Pathway" "" "1" "0" "41.4" "56.7" "67.7" "300.2" "111.9" "54.3" "125.7" "113.5" "97.3" "473.4" "726.9" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "O14782" "Kinesin-like protein KIF3C OS=Homo sapiens OX=9606 GN=KIF3C PE=1 SV=3" "1" "1" "1" "1" "793" "89.4" "8.22" "231.65" "" "1" "" "" "" "" "" "" "" "" "" "" "" "0" "0" "150.4" "136.5" "184.5" "521.0" "234.7" "117.5" "161.4" "118.3" "129.0" "236.6" "199.7" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9P0M9" "39S ribosomal protein L27, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1" "4" "1" "1" "1" "148" "16.1" "10.42" "231.51" "" "1" "" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01016" "51264" "ENSG00000108826" "MRPL27" "B2RE14; hsa:51264; Q9P0M9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q15287" "RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1" "2" "1" "1" "1" "305" "34.2" "11.84" "231.32" "" "1" "" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10921" "ENSG00000205937" "RNPS1" "A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "7" "0" "47.4" "37.0" "55.0" "176.4" "70.7" "35.4" "64.8" "35.9" "37.0" "113.1" "83.3" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0" "1" "1" "1" "1508" "168.5" "6.62" "231.09" "" "1" "" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894" "25929" "ENSG00000082516" "GEMIN5" "hsa:25929; Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "25.9" "20.0" "23.0" "67.9" "39.6" "12.7" "35.2" "16.1" "24.8" "108.0" "149.0" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "False" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0" "1" "1" "1" "3859" "437.3" "8.19" "230.32" "" "1" "" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex" "Rett syndrome causing genes" "4" "0" "180.5" "126.6" "196.1" "447.1" "273.0" "85.9" "99.1" "176.4" "127.5" "125.2" "102.4" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""