"Checked"	"Master"	"Accession"	"Description"	"Coverage [%]"	"# Peptides"	"# PSMs"	"# Unique Peptides"	"# AAs"	"MW [kDa]"	"calc. pI"	"Score MS Amanda 2.0: MS Amanda 2.0"	"Score Sequest HT: Sequest HT"	"# Peptides (by Search Engine): MS Amanda 2.0"	"# Peptides (by Search Engine): Sequest HT"	"Biological Process"	"Cellular Component"	"Molecular Function"	"Pfam IDs"	"Entrez Gene ID"	"Ensembl Gene ID"	"Gene Symbol"	"Gene ID"	"WikiPathways"	"Reactome Pathways"	"# Protein Pathway Groups"	"# Razor Peptides"	"Abundances (Grouped): 126"	"Abundances (Grouped): 127N"	"Abundances (Grouped): 127C"	"Abundances (Grouped): 128N"	"Abundances (Grouped): 128C"	"Abundances (Grouped): 129N"	"Abundances (Grouped): 129C"	"Abundances (Grouped): 130N"	"Abundances (Grouped): 130C"	"Abundances (Grouped): 131N"	"Abundances (Grouped): 131C"	"Abundances (Grouped) CV [%]: 126"	"Abundances (Grouped) CV [%]: 127N"	"Abundances (Grouped) CV [%]: 127C"	"Abundances (Grouped) CV [%]: 128N"	"Abundances (Grouped) CV [%]: 128C"	"Abundances (Grouped) CV [%]: 129N"	"Abundances (Grouped) CV [%]: 129C"	"Abundances (Grouped) CV [%]: 130N"	"Abundances (Grouped) CV [%]: 130C"	"Abundances (Grouped) CV [%]: 131N"	"Abundances (Grouped) CV [%]: 131C"	"Found in Sample: F11: 126, Sample"	"Found in Sample: F11: 127N, Sample"	"Found in Sample: F11: 127C, Sample"	"Found in Sample: F11: 128N, Sample"	"Found in Sample: F11: 128C, Sample"	"Found in Sample: F11: 129N, Sample"	"Found in Sample: F11: 129C, Sample"	"Found in Sample: F11: 130N, Sample"	"Found in Sample: F11: 130C, Sample"	"Found in Sample: F11: 131N, Sample"	"Found in Sample: F11: 131C, Sample"	"# Protein Groups"	"Modifications"
"False"	"IsMasterProtein"	"Q13813"	"Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3"	"45"	"103"	"223"	"103"	"2472"	"284.4"	"5.35"	"38385.27"	"397.07"	"88"	"95"	"cell organization and biogenesis"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00018, Pf00435, Pf08726, Pf13499"	"6709"	"ENSG00000197694"	"SPTAN1"	"hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0"	"Fas ligand pathway and stress induction of heat shock proteins"	"RAF/MAP kinase cascade; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; RHOU GTPase cycle; Neutrophil degranulation; COPI-mediated anterograde transport; Nephrin family interactions; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins"	"12"	"0"	"6515.0"	"4304.6"	"6421.4"	"8571.6"	"10632.0"	"9267.8"	"22338.2"	"21302.8"	"13527.5"	"18946.3"	"27505.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q08211"	"ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4"	"42"	"45"	"134"	"45"	"1270"	"140.9"	"6.84"	"26419.82"	"255.06"	"38"	"41"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes"	"cytosol;cytoskeleton;translational apparatus;nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00035, Pf00270, Pf00271, Pf04408, Pf07717"	"1660"	"ENSG00000135829"	"DHX9"	"B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556"	"MECP2 and associated Rett syndrome; mRNA processing"	"mRNA Splicing - Major Pathway; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production"	"5"	"0"	"2572.5"	"1814.6"	"2446.1"	"3008.8"	"3689.6"	"3336.7"	"9932.2"	"12077.4"	"8984.9"	"9831.7"	"12214.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01082"	"Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2"	"30"	"66"	"135"	"60"	"2364"	"274.4"	"5.57"	"25066.94"	"244.16"	"59"	"62"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00169, Pf00307, Pf00435"	"6711"	"ENSG00000115306"	"SPTBN1"	"B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99"	"Sudden infant death syndrome (SIDS) susceptibility pathways"	"RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Signaling by FLT3 fusion proteins; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Interaction between L1 and Ankyrins"	"11"	"6"	"2996.2"	"1889.8"	"2948.1"	"3809.9"	"5032.4"	"4292.6"	"11415.4"	"10939.8"	"6781.6"	"9693.9"	"15098.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08670"	"Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4"	"60"	"38"	"156"	"36"	"466"	"53.6"	"5.12"	"33064.55"	"232.90"	"34"	"35"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00038, Pf04732"	"7431"	"ENSG00000026025"	"VIM"	"B0YJC2; D3DRU4; hsa:7431; P08670; Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3"	"Allograft rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; TROP2 regulatory signaling; CKAP4 signaling pathway map; A network map of Macrophage-stimulating protein (MSP) signaling; T-cell receptor signaling pathway"	"Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins"	"21"	"2"	"5967.7"	"4342.6"	"6174.5"	"9318.7"	"10907.6"	"8631.4"	"11884.4"	"10169.1"	"6105.9"	"8525.5"	"11039.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22626"	"Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2"	"78"	"23"	"104"	"21"	"353"	"37.4"	"8.95"	"16246.44"	"223.51"	"18"	"20"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"non-structural extracellular;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"3181"	"ENSG00000122566"	"HNRNPA2B1"	"A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2"	"mRNA processing"	"mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Processing of Capped Intron-Containing Pre-mRNA"	"4"	"3"	"6641.1"	"5138.3"	"5939.3"	"7158.2"	"8913.6"	"7888.1"	"17974.3"	"15457.8"	"11411.7"	"14140.7"	"18659.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61978"	"Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1"	"54"	"27"	"109"	"27"	"463"	"50.9"	"5.54"	"19929.44"	"207.10"	"22"	"25"	"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf08067"	"3190"	"ENSG00000165119"	"HNRNPK"	"hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62"	"mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; HCMV Late Events; SUMOylation of RNA binding proteins"	"6"	"0"	"3930.4"	"3006.6"	"3761.5"	"6978.7"	"8618.2"	"6934.5"	"16401.3"	"15266.0"	"10688.3"	"9466.4"	"9042.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23284"	"Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2"	"65"	"22"	"111"	"22"	"216"	"23.7"	"9.41"	"19869.90"	"206.38"	"17"	"21"	"protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00160"	"5479"	"ENSG00000166794"	"PPIB"	"A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5"	"Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta"	"Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses"	"4"	"0"	"745.8"	"473.5"	"738.3"	"952.4"	"1251.3"	"1076.9"	"7658.1"	"12484.9"	"18457.2"	"27711.4"	"36388.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11142"	"Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1"	"60"	"38"	"114"	"30"	"646"	"70.9"	"5.52"	"21418.52"	"196.69"	"33"	"35"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00012"	"3312"	"ENSG00000109971"	"HSPA8"	"hsa:3312; P11142; Q9H3R6"	"Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome"	"AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase"	"24"	"10"	"4772.9"	"3241.1"	"5057.1"	"7448.9"	"8467.5"	"7619.2"	"14481.5"	"14925.5"	"8803.0"	"11164.3"	"15916.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63010"	"AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1"	"32"	"34"	"86"	"20"	"937"	"104.5"	"5.38"	"12941.06"	"183.06"	"26"	"31"	"transport;developmental processes"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf01602, Pf02883, Pf09066"	"163"	"ENSG00000006125"	"AP2B1"	"A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19"	"Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome"	"Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD4; MHC class II antigen presentation; Recycling pathway of L1; Retrograde neurotrophin signalling; Potential therapeutics for SARS; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2"	"20"	"15"	"756.6"	"473.4"	"764.5"	"1020.7"	"1302.5"	"1133.8"	"4456.1"	"8390.1"	"11889.3"	"20737.5"	"35443.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04264"	"Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6"	"40"	"34"	"109"	"27"	"644"	"66.0"	"8.12"	"23350.24"	"167.82"	"33"	"31"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"bone, tooth or skin structural activity;other molecular function"	"Pf00038, Pf16208, Pf16210"	"3848"	"ENSG00000167768"	"KRT1"	"B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298"	"Corticotropin-releasing hormone signaling pathway"	"Formation of the cornified envelope; Neutrophil degranulation"	"4"	"8"	"4423.9"	"1401.5"	"1201.0"	"1306.8"	"5333.9"	"4127.3"	"6156.9"	"49854.7"	"2030.6"	"3113.2"	"3222.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20700"	"Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2"	"65"	"37"	"101"	"33"	"586"	"66.4"	"5.16"	"18481.95"	"167.46"	"34"	"32"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;cytoskeleton;nucleus"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00038, Pf00932"	"4001"	"ENSG00000113368"	"LMNB1"	"B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6"	"Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome"	"Meiotic synapsis; RHOD GTPase cycle; RHOF GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)"	"14"	"4"	"4285.0"	"3183.5"	"4117.0"	"5794.0"	"6917.3"	"5837.3"	"13624.6"	"12827.0"	"7810.6"	"10773.3"	"13690.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7KZF4"	"Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1"	"45"	"33"	"86"	"33"	"910"	"101.9"	"7.17"	"14946.98"	"163.98"	"26"	"33"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00565, Pf00567"	"27044"	"ENSG00000197157"	"SND1"	"hsa:27044; Q13122; Q7KZF4; Q96AG0"	"VEGFA-VEGFR2 signaling"	"Signaling by BRAF and RAF1 fusions"	"2"	"0"	"1774.4"	"1145.8"	"1687.6"	"1879.9"	"2461.6"	"2199.8"	"11583.6"	"11190.5"	"8111.2"	"9771.4"	"13344.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04406"	"Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3"	"58"	"21"	"64"	"21"	"335"	"36.0"	"8.46"	"8926.19"	"144.99"	"14"	"20"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00044, Pf02800"	"2597"	"ENSG00000111640"	"GAPDH"	"E7EUT4; hsa:2597; P00354; P04406; Q53X65"	"Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Glycolysis; Gluconeogenesis"	"16"	"0"	"1522.2"	"1090.3"	"1402.8"	"1647.4"	"2130.4"	"1847.3"	"8303.6"	"7996.3"	"5725.3"	"6114.6"	"9839.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P0DMV9"	"Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1"	"54"	"29"	"76"	"23"	"641"	"70.0"	"5.66"	"13265.81"	"144.76"	"22"	"27"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00012"	"3303; 3304"	"ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804"	"HSPA1B"	"B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0"	"Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection; CKAP4 signaling pathway map"	"Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase"	"12"	"0"	"2276.9"	"1425.6"	"2501.6"	"3759.0"	"4188.7"	"3821.4"	"7074.5"	"6799.9"	"4425.3"	"5619.1"	"8229.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92841"	"Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2"	"39"	"28"	"80"	"21"	"729"	"80.2"	"8.27"	"15044.18"	"137.81"	"27"	"27"	"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"10521"	"ENSG00000100201"	"DDX17"	"B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841"	"Novel intracellular components of RIG-I-like receptor pathway"	"SUMOylation of transcription cofactors"	"2"	"8"	"1894.5"	"1342.7"	"1641.9"	"1995.3"	"2626.2"	"2147.3"	"7592.5"	"6633.9"	"4770.0"	"5708.6"	"6276.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13645"	"Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6"	"43"	"27"	"69"	"24"	"584"	"58.8"	"5.21"	"12774.05"	"137.05"	"23"	"25"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;cytosol;cytoskeleton;other cell component"	"bone, tooth or skin structural activity;other molecular function"	"Pf00038"	"3858"	"ENSG00000186395"	"KRT10"	"hsa:3858; P13645; Q14664; Q8N175"	""	"Formation of the cornified envelope"	"2"	"4"	"2289.0"	"1047.1"	"897.9"	"766.3"	"2854.8"	"3401.0"	"2482.2"	"42868.3"	"1169.8"	"819.2"	"1790.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12906"	"Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3"	"35"	"23"	"66"	"21"	"894"	"95.3"	"8.76"	"10554.05"	"135.28"	"18"	"23"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00035, Pf07528"	"3609"	"ENSG00000129351"	"ILF3"	"A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2"	""	"Regulation of CDH11 gene transcription"	"1"	"3"	"1474.3"	"992.4"	"1433.2"	"1751.6"	"2244.8"	"1942.5"	"6397.0"	"5437.6"	"3547.1"	"4728.8"	"5655.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00159"	"Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4"	"35"	"35"	"72"	"34"	"1063"	"121.6"	"9.41"	"13064.06"	"131.93"	"29"	"29"	"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00063, Pf00612, Pf06017"	"4641"	"ENSG00000197879"	"MYO1C"	"hsa:4641; O00159; Q4LE56; Q6NVJ7; Q86Y95"	"VEGFA-VEGFR2 signaling; Insulin signaling; 10q11.21q11.23 copy number variation syndrome"	"Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea"	"8"	"1"	"696.2"	"557.0"	"782.8"	"1016.5"	"1257.6"	"1234.6"	"3810.3"	"5891.1"	"5602.8"	"10198.2"	"17546.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7KZ85"	"Transcription elongation factor SPT6 OS=Homo sapiens OX=9606 GN=SUPT6H PE=1 SV=2"	"26"	"37"	"71"	"37"	"1726"	"198.9"	"4.91"	"12438.88"	"130.49"	"31"	"32"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00575, Pf14632, Pf14633, Pf14635, Pf14639, Pf14641, Pf17674"	"6830"	"ENSG00000109111"	"SUPT6H"	"A7E2B4; hsa:6830; Q15737; Q6GMQ4; Q7KYW9; Q7KZ85; Q7LDK4; Q8N526; Q92775; Q96AH3; Q9BTH9; Q9BTI2"	""	"Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events"	"3"	"0"	"1899.4"	"1254.1"	"1800.6"	"2496.0"	"3102.6"	"2723.4"	"7204.3"	"7309.1"	"4856.7"	"5823.1"	"7638.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6P2Q9"	"Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2"	"22"	"45"	"85"	"45"	"2335"	"273.4"	"8.84"	"14784.17"	"128.54"	"39"	"39"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134"	"10594"	"ENSG00000174231; ENSG00000274442"	"PRPF8"	"hsa:10594; O14547; O75965; Q6P2Q9"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"3138.4"	"2019.7"	"2704.0"	"3365.8"	"4333.6"	"3692.2"	"10383.4"	"9693.8"	"6560.3"	"9645.3"	"12484.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q00839"	"Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6"	"35"	"29"	"73"	"28"	"825"	"90.5"	"6.00"	"13984.21"	"121.60"	"22"	"23"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00622, Pf02037, Pf13671"	"3192"	"ENSG00000153187"	"HNRNPU"	"hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09"	"mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"4"	"1"	"4235.1"	"2559.1"	"3433.7"	"4945.7"	"6566.5"	"5447.0"	"14120.0"	"11111.9"	"5341.4"	"9316.2"	"13386.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04075"	"Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2"	"55"	"23"	"65"	"18"	"364"	"39.4"	"8.09"	"13688.71"	"121.25"	"22"	"20"	"cell organization and biogenesis;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00274"	"226"	"ENSG00000149925"	"ALDOA"	"B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2"	"VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Glycolysis; Gluconeogenesis; Neutrophil degranulation; Platelet degranulation"	"11"	"6"	"3052.4"	"2100.5"	"2912.1"	"3578.9"	"4157.1"	"3950.6"	"6936.2"	"7017.1"	"4957.7"	"5523.6"	"9122.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95782"	"AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3"	"30"	"27"	"67"	"20"	"977"	"107.5"	"7.03"	"10206.55"	"117.85"	"22"	"26"	"transport;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf01602, Pf02296, Pf02883"	"160"	"ENSG00000196961"	"AP2A1"	"hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070"	"Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission"	"MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation"	"20"	"7"	"559.1"	"364.5"	"562.3"	"738.9"	"961.5"	"844.2"	"2914.1"	"5659.9"	"8592.5"	"14232.0"	"25232.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P02545"	"Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1"	"37"	"29"	"77"	"28"	"664"	"74.1"	"7.02"	"14665.66"	"116.48"	"29"	"28"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00038, Pf00932"	"4000"	"ENSG00000160789"	"LMNA"	"B4DI32; D3DVB0; D6RAQ3; E7EUI9; hsa:4000; P02545; P02546; Q5I6Y4; Q5I6Y6; Q5TCJ2; Q5TCJ3; Q6UYC3; Q969I8; Q96JA2"	"Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Primary ovarian insufficiency"	"XBP1(S) activates chaperone genes; Signaling by BRAF and RAF1 fusions"	"13"	"0"	"1919.6"	"1388.7"	"1959.9"	"2876.2"	"3497.0"	"2924.5"	"13375.2"	"12485.1"	"7967.5"	"10160.4"	"13233.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75643"	"U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2"	"19"	"38"	"78"	"38"	"2136"	"244.4"	"6.06"	"13944.68"	"115.58"	"35"	"35"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00270, Pf00271, Pf02889, Pf18149"	"23020"	"ENSG00000144028"	"SNRNP200"	"hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0"	"2q11.2 copy number variation syndrome"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"1933.6"	"1296.6"	"1771.0"	"2208.8"	"2961.1"	"2508.1"	"6710.6"	"6181.6"	"3933.3"	"5623.6"	"7480.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23246"	"Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2"	"33"	"24"	"71"	"23"	"707"	"76.1"	"9.44"	"14085.44"	"113.76"	"22"	"23"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf08075"	"6421"	"ENSG00000116560"	"SFPQ"	"hsa:6421; P23246; P30808; Q5SZ71"	"mRNA processing; Type 2 papillary renal cell carcinoma"	"Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing"	"4"	"1"	"2074.4"	"1427.1"	"1962.9"	"2212.7"	"2608.9"	"2274.7"	"9704.6"	"8955.3"	"6298.2"	"7168.5"	"8273.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08133"	"Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3"	"46"	"29"	"62"	"29"	"673"	"75.8"	"5.60"	"9544.07"	"113.20"	"22"	"29"	"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes"	"other membranes;mitochondrion;other cytoplasmic organelle;other cell component"	"transporter activity;cytoskeletal activity;other molecular function"	"Pf00191"	"309"	"ENSG00000197043"	"ANXA6"	"B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79"	"Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation"	"Smooth Muscle Contraction"	"3"	"0"	"1266.3"	"1107.6"	"1365.0"	"1545.8"	"1805.1"	"2038.0"	"5647.1"	"4806.5"	"3583.4"	"6817.5"	"23318.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43491"	"Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1"	"31"	"28"	"59"	"25"	"1005"	"112.5"	"5.44"	"11321.90"	"112.51"	"25"	"25"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380"	"2037"	"ENSG00000079819"	"EPB41L2"	"B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2"	"Splicing factor NOVA regulated synaptic proteins"	"Neurexins and neuroligins"	"2"	"3"	"1541.8"	"984.1"	"1528.5"	"2382.8"	"2929.9"	"2577.9"	"6732.1"	"6247.6"	"4565.4"	"7622.9"	"11348.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94973"	"AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2"	"33"	"25"	"58"	"18"	"939"	"103.9"	"6.96"	"8673.51"	"112.01"	"18"	"24"	"transport"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf01602, Pf02296, Pf02883"	"161"	"ENSG00000183020"	"AP2A2"	"hsa:161; O75403; O94973; Q53ET1; Q96SI8"	"Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission"	"Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation"	"17"	"0"	"200.4"	"129.5"	"189.9"	"228.6"	"366.0"	"292.1"	"909.0"	"1728.8"	"2287.3"	"4048.1"	"6918.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62258"	"14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1"	"67"	"19"	"72"	"17"	"255"	"29.2"	"4.74"	"14546.19"	"111.40"	"18"	"18"	"stress response;transport;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00244"	"7531"	"ENSG00000108953; ENSG00000274474"	"YWHAE"	"B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4"	"Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Regulation of HSF1-mediated heat shock response; HSF1 activation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; Signaling by Hippo; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; NADE modulates death signalling"	"26"	"4"	"2587.2"	"1890.5"	"2662.6"	"3822.3"	"4209.1"	"4043.5"	"7703.4"	"7911.8"	"5302.1"	"6118.3"	"8096.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14866"	"Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2"	"38"	"14"	"50"	"13"	"589"	"64.1"	"8.22"	"9774.91"	"110.99"	"10"	"14"	"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf11835, Pf13893"	"3191"	"ENSG00000104824; ENSG00000282947"	"HNRNPL"	"A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3"	"mRNA processing; Hippocampal synaptogenesis and neurogenesis"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"4"	"2"	"2050.8"	"1381.9"	"1936.8"	"2336.5"	"2801.9"	"2428.0"	"6052.5"	"5055.7"	"3388.4"	"4597.3"	"5101.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12270"	"Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3"	"18"	"40"	"76"	"40"	"2363"	"267.1"	"5.02"	"14581.14"	"110.94"	"38"	"33"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"other membranes;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf07926"	"7175"	"ENSG00000047410"	"TPR"	"hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; ISG15 antiviral mechanism; Signaling by ALK fusions and activated point mutants; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"29"	"0"	"1782.9"	"1124.0"	"1816.5"	"2955.6"	"3481.8"	"2822.6"	"8167.2"	"7447.6"	"4620.7"	"5968.0"	"8117.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31943"	"Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4"	"40"	"14"	"55"	"5"	"449"	"49.2"	"6.30"	"9466.08"	"110.43"	"11"	"13"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf08080"	"3187"	"ENSG00000169045; ENSG00000284254"	"HNRNPH1"	"B3KW86; D3DWQ2; hsa:3187; P31943; Q6IBM4"	"MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells"	"mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA"	"6"	"7"	"1388.5"	"1195.5"	"1780.2"	"2677.8"	"2717.6"	"2370.3"	"5181.0"	"4753.0"	"3026.7"	"3460.3"	"3634.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06748"	"Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2"	"55"	"19"	"65"	"19"	"294"	"32.6"	"4.78"	"11867.93"	"109.38"	"17"	"17"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function"	"Pf03066, Pf16276"	"4869"	"ENSG00000181163"	"NPM1"	"A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7"	""	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Nuclear events stimulated by ALK signaling in cancer; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; SARS-CoV-1-host interactions"	"9"	"0"	"3303.5"	"2094.0"	"3137.1"	"4669.8"	"5628.5"	"4971.1"	"15303.7"	"14230.2"	"10209.1"	"11178.1"	"13995.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55072"	"Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4"	"49"	"31"	"64"	"31"	"806"	"89.3"	"5.26"	"13176.72"	"108.70"	"26"	"26"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00004, Pf02359, Pf02933, Pf09336, Pf17862"	"7415"	"ENSG00000165280"	"VCP"	"B2R5T8; hsa:7415; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5"	"Alstrom syndrome; Clock-controlled autophagy in bone metabolism"	"Neutrophil degranulation; RHOH GTPase cycle; Aggrephagy; HSF1 activation; ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; E3 ubiquitin ligases ubiquitinate target proteins; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle"	"20"	"0"	"2865.6"	"2082.1"	"2954.8"	"3664.4"	"4163.6"	"4090.4"	"6220.1"	"6217.6"	"4242.4"	"5124.4"	"7522.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07910"	"Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4"	"39"	"20"	"75"	"20"	"306"	"33.7"	"5.08"	"15827.07"	"107.84"	"20"	"16"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"3183"	"ENSG00000092199"	"HNRNPC"	"D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; SUMOylation of RNA binding proteins; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle"	"6"	"0"	"4083.4"	"2742.5"	"3629.7"	"4509.8"	"5705.8"	"4969.0"	"12231.3"	"10120.2"	"6678.3"	"8925.7"	"12124.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13639"	"Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4"	"35"	"31"	"64"	"30"	"858"	"95.3"	"6.83"	"12123.23"	"107.22"	"27"	"27"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00009, Pf00679, Pf03144, Pf03764, Pf14492"	"1938"	"ENSG00000167658"	"EEF2"	"A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86"	"Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway"	"Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2"	"9"	"1"	"1827.3"	"1278.2"	"1789.8"	"2691.7"	"3280.3"	"3026.6"	"6316.3"	"6364.7"	"4093.0"	"5485.7"	"9790.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35908"	"Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2"	"38"	"27"	"69"	"19"	"639"	"65.4"	"8.00"	"13850.31"	"103.13"	"27"	"23"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;cytosol;cytoskeleton;other cell component"	"bone, tooth or skin structural activity;cytoskeletal activity"	"Pf00038, Pf16208"	"3849"	"ENSG00000172867"	"KRT2"	"hsa:3849; P35908; Q4VAQ2"	""	"Formation of the cornified envelope"	"2"	"4"	"2269.8"	"880.2"	"892.7"	"695.3"	"2963.1"	"4094.8"	"2196.8"	"23939.7"	"1128.2"	"1181.0"	"1883.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14103"	"Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1"	"31"	"17"	"57"	"14"	"355"	"38.4"	"7.81"	"10355.86"	"100.68"	"16"	"15"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf08143"	"3184"	"ENSG00000138668"	"HNRNPD"	"A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"3"	"5"	"2083.2"	"1637.0"	"2110.5"	"2693.5"	"3254.6"	"2782.8"	"7864.0"	"6817.8"	"4825.5"	"5804.5"	"8029.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q03252"	"Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4"	"36"	"26"	"59"	"22"	"620"	"69.9"	"5.59"	"10020.72"	"100.36"	"24"	"26"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;cytoskeleton;nucleus"	"cytoskeletal activity;other molecular function"	"Pf00038, Pf00932"	"84823"	"ENSG00000176619"	"LMNB2"	"hsa:84823; O75292; Q03252; Q14734; Q96DF6"	"Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome"	""	"6"	"0"	"1968.2"	"1363.4"	"1775.6"	"2440.9"	"3056.4"	"2507.0"	"6044.5"	"5635.4"	"3327.5"	"4698.9"	"5783.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P38646"	"Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2"	"40"	"26"	"53"	"25"	"679"	"73.6"	"6.16"	"8538.71"	"99.34"	"22"	"23"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00012"	"3313"	"ENSG00000113013"	"HSPA9"	"B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56"	"Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis"	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation"	"6"	"0"	"2340.3"	"1503.9"	"2311.5"	"3318.7"	"3904.7"	"3603.6"	"5448.4"	"5401.6"	"3700.3"	"4364.2"	"6451.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q10567"	"AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=2"	"24"	"22"	"50"	"8"	"949"	"104.6"	"5.06"	"8566.32"	"98.65"	"17"	"21"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"156.6"	"109.7"	"153.9"	"209.6"	"286.7"	"252.9"	"668.1"	"939.1"	"1056.8"	"1838.1"	"3250.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00571"	"ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3"	"46"	"29"	"60"	"28"	"662"	"73.2"	"7.18"	"11459.01"	"97.76"	"26"	"25"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"1654"	"ENSG00000215301"	"DDX3X"	"A8K538; B4E3E8; hsa:1654; O00571; O15536"	"Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection"	"Neutrophil degranulation"	"3"	"1"	"1310.1"	"810.4"	"1282.1"	"1727.5"	"2221.0"	"1748.2"	"8618.2"	"7203.2"	"4243.7"	"4813.2"	"5052.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15149"	"Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3"	"9"	"30"	"57"	"29"	"4684"	"531.5"	"5.96"	"9594.84"	"97.62"	"24"	"28"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf00681, Pf03501, Pf17902, Pf18373"	"5339"	"ENSG00000178209"	"PLEC"	"hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383"	"Envelope proteins and their potential roles in EDMD physiopathology"	"Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly"	"4"	"2"	"1173.5"	"849.6"	"1191.1"	"1541.4"	"1972.1"	"1573.2"	"3806.9"	"3503.3"	"2309.8"	"2895.3"	"3537.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15393"	"Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4"	"23"	"25"	"60"	"25"	"1217"	"135.5"	"5.26"	"11237.60"	"96.52"	"23"	"22"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03178, Pf10433"	"23450"	"ENSG00000189091"	"SF3B3"	"hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"2150.3"	"1560.1"	"2136.9"	"2687.5"	"3163.6"	"2896.8"	"7020.4"	"6548.5"	"4431.5"	"5888.4"	"8039.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P32121"	"Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2"	"52"	"17"	"42"	"14"	"409"	"46.1"	"7.69"	"7050.72"	"95.69"	"14"	"17"	"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00339, Pf02752"	"409"	"ENSG00000141480"	"ARRB2"	"B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6"	"Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells"	"Ub-specific processing proteases; Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; Activation of SMO; G alpha (s) signalling events; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants"	"27"	"3"	"293.3"	"211.2"	"299.2"	"402.6"	"521.4"	"531.4"	"1901.6"	"4518.0"	"6413.8"	"8564.1"	"9603.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15459"	"Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1"	"30"	"21"	"48"	"21"	"793"	"88.8"	"5.22"	"9385.24"	"94.41"	"17"	"21"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf00240, Pf01805, Pf12230"	"10291"	"ENSG00000099995"	"SF3A1"	"E9PAW1; hsa:10291; Q15459"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"1069.7"	"763.5"	"1138.9"	"1393.7"	"1679.6"	"1416.5"	"3589.1"	"3311.4"	"2280.3"	"2745.7"	"3622.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P43243"	"Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2"	"34"	"23"	"49"	"23"	"847"	"94.6"	"6.25"	"8652.45"	"94.36"	"18"	"22"	"stress response;developmental processes;other biological processes"	"other membranes;nucleus"	"nucleic acid binding activity;other molecular function"	""	"9782"	"ENSG00000015479"	"MATR3"	"B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27"	""	""	"0"	"0"	"2620.7"	"1448.3"	"2103.6"	"2918.3"	"3865.4"	"3385.1"	"6305.5"	"4836.4"	"2523.1"	"4860.2"	"6523.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43390"	"Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1"	"46"	"27"	"51"	"17"	"633"	"70.9"	"8.13"	"8385.52"	"93.56"	"23"	"25"	"RNA metabolism OR transcription;other metabolic processes"	"ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf18360"	"10236"	"ENSG00000125944; ENSG00000282958"	"HNRNPR"	"hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"3"	"10"	"2281.4"	"1574.6"	"2213.0"	"2767.3"	"3447.6"	"2974.2"	"6641.1"	"5784.5"	"3555.2"	"5105.7"	"7081.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14683"	"Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2"	"28"	"39"	"70"	"39"	"1233"	"143.1"	"7.64"	"11056.36"	"92.61"	"35"	"33"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02463, Pf06470"	"8243"	"ENSG00000072501"	"SMC1A"	"hsa:8243; O14995; Q14683; Q16351; Q2M228"	"miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome causing genes; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Estrogen-dependent gene expression; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin"	"22"	"0"	"1565.0"	"931.8"	"1471.8"	"1733.7"	"2507.0"	"1987.1"	"10666.3"	"9928.0"	"5868.7"	"8026.4"	"11084.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P54577"	"Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4"	"52"	"27"	"59"	"27"	"528"	"59.1"	"7.05"	"11311.49"	"91.05"	"27"	"26"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf00579, Pf01588"	"8565"	"ENSG00000134684"	"YARS1"	"B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1"	"Nephrotic syndrome"	"Cytosolic tRNA aminoacylation"	"2"	"0"	"834.1"	"515.9"	"859.8"	"1188.7"	"1686.3"	"1557.3"	"6913.2"	"7926.6"	"7984.6"	"13151.6"	"21378.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35637"	"RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1"	"18"	"11"	"53"	"8"	"526"	"53.4"	"9.36"	"11129.15"	"91.04"	"9"	"8"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf00641"	"2521"	"ENSG00000089280"	"FUS"	"hsa:2521; P35637; Q9H4A8"	"MECP2 and associated Rett syndrome; mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"4"	"4"	"2316.4"	"1878.0"	"2239.7"	"2333.9"	"2779.5"	"2464.1"	"7062.2"	"6445.8"	"5743.4"	"5214.0"	"5761.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31946"	"14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3"	"67"	"14"	"51"	"9"	"246"	"28.1"	"4.83"	"10322.54"	"90.53"	"13"	"14"	"transport;signal transduction;other biological processes"	"other membranes;cytosol;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00244"	"7529"	"ENSG00000166913"	"YWHAB"	"A8K9K2; E1P616; hsa:7529; P31946"	"Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by BRAF and RAF1 fusions; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"	"33"	"7"	"1081.0"	"856.6"	"1294.0"	"1712.9"	"1920.0"	"1757.1"	"3599.7"	"3562.5"	"2451.0"	"2858.8"	"3234.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75533"	"Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3"	"23"	"25"	"63"	"25"	"1304"	"145.7"	"7.09"	"11341.45"	"90.51"	"23"	"24"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf08920"	"23451"	"ENSG00000115524"	"SF3B1"	"E9PCH3; hsa:23451; O75533"	"mRNA processing; 10q11.21q11.23 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"5"	"0"	"1661.2"	"1016.6"	"1467.1"	"1911.6"	"2479.7"	"2105.8"	"5986.0"	"5317.2"	"3165.2"	"4650.2"	"6216.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08238"	"Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4"	"37"	"25"	"55"	"15"	"724"	"83.2"	"5.03"	"8683.09"	"90.29"	"20"	"22"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component"	"enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00183, Pf02518"	"3326"	"ENSG00000096384"	"HSP90AB1"	"B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6"	"Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway"	"The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin"	"23"	"10"	"1771.0"	"1253.1"	"1763.5"	"2992.6"	"3508.6"	"2896.9"	"4873.9"	"4578.5"	"2719.5"	"3842.8"	"4850.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60709"	"Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1"	"40"	"16"	"55"	"3"	"375"	"41.7"	"5.48"	"11796.84"	"90.22"	"13"	"15"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00022"	"60"	"ENSG00000075624"	"ACTB"	"hsa:60; P02570; P60709; P70514; P99021; Q11211; Q64316; Q75MN2; Q96B34; Q96HG5"	"Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway"	"RHO GTPases activate IQGAPs; UCH proteinases; Clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHOF GTPase cycle; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate  to CCT/TriC; Signaling by RAF1 mutants; Adherens junctions interactions; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions"	"47"	"22"	"3036.9"	"2435.3"	"2775.4"	"3452.6"	"4582.3"	"4442.6"	"8883.7"	"6935.7"	"4309.6"	"6681.9"	"8575.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52597"	"Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3"	"50"	"17"	"50"	"14"	"415"	"45.6"	"5.58"	"7150.35"	"89.64"	"13"	"16"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf08080"	"3185"	"ENSG00000169813"	"HNRNPF"	"B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2"	"MECP2 and associated Rett syndrome"	"mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"	"5"	"2"	"2236.3"	"1920.4"	"3104.6"	"5072.3"	"4893.2"	"3960.9"	"6485.8"	"6191.3"	"4068.7"	"4500.5"	"5105.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15233"	"Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4"	"32"	"18"	"55"	"17"	"471"	"54.2"	"8.95"	"11019.65"	"87.31"	"16"	"18"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf08075"	"4841"	"ENSG00000147140"	"NONO"	"B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5"	"mRNA processing"	""	"1"	"0"	"1374.4"	"835.9"	"1274.5"	"1514.9"	"1881.7"	"1603.8"	"6561.5"	"5994.0"	"3946.0"	"4625.7"	"5741.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15029"	"116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1"	"28"	"23"	"48"	"22"	"972"	"109.4"	"5.00"	"8305.49"	"87.06"	"19"	"23"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004"	"9343"	"ENSG00000108883"	"EFTUD2"	"B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0"	"mRNA processing; Ciliary landscape"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"4"	"0"	"1197.2"	"781.8"	"1117.7"	"1411.0"	"1748.7"	"1560.9"	"4212.9"	"3993.0"	"2873.8"	"3947.1"	"5211.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14618"	"Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4"	"43"	"16"	"39"	"16"	"531"	"57.9"	"7.84"	"6891.44"	"86.05"	"12"	"12"	"cell organization and biogenesis;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf00224, Pf02887"	"5315"	"ENSG00000067225"	"PKM"	"A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2"	"Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Neutrophil degranulation"	"10"	"0"	"970.6"	"714.0"	"1004.7"	"1844.3"	"2054.6"	"1763.5"	"3413.4"	"3440.1"	"2006.4"	"2267.3"	"2491.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60506"	"Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2"	"44"	"24"	"47"	"14"	"623"	"69.6"	"8.59"	"7959.18"	"85.69"	"19"	"23"	"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf18360"	"10492"	"ENSG00000135316"	"SYNCRIP"	"E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583"	""	""	"0"	"0"	"672.9"	"485.4"	"654.8"	"826.8"	"1070.1"	"955.2"	"2169.1"	"2101.5"	"1311.7"	"1791.7"	"2837.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q07955"	"Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2"	"48"	"16"	"50"	"16"	"248"	"27.7"	"10.36"	"7653.28"	"85.22"	"13"	"15"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"6426"	"ENSG00000136450"	"SRSF1"	"B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing"	"7"	"0"	"1414.0"	"1182.4"	"1331.4"	"1619.1"	"1902.4"	"1598.0"	"4616.8"	"4372.2"	"4242.2"	"5017.9"	"4517.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2J2"	"Band 4.1-like protein 3 OS=Homo sapiens OX=9606 GN=EPB41L3 PE=1 SV=2"	"23"	"22"	"47"	"19"	"1087"	"120.6"	"5.19"	"8257.75"	"85.03"	"18"	"19"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380"	"23136"	"ENSG00000082397"	"EPB41L3"	"B7Z4I5; F5GX05; hsa:23136; O95713; Q9BRP5; Q9Y2J2"	"Splicing factor NOVA regulated synaptic proteins"	"Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea"	"4"	"0"	"723.5"	"476.1"	"777.5"	"1089.9"	"1356.4"	"1183.7"	"3577.9"	"4030.6"	"3047.9"	"5409.6"	"8442.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51991"	"Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2"	"38"	"14"	"44"	"12"	"378"	"39.6"	"9.01"	"8181.77"	"84.94"	"11"	"13"	"RNA metabolism OR transcription;other metabolic processes;transport"	"nucleus;other cell component"	"transporter activity;nucleic acid binding activity"	"Pf00076"	"220988"	"ENSG00000170144"	"HNRNPA3"	"D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5"	""	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"2"	"0"	"1541.4"	"1205.5"	"1515.1"	"1859.4"	"2195.7"	"1924.6"	"4335.4"	"3851.1"	"2741.9"	"3719.5"	"4212.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TAF3"	"WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1"	"39"	"19"	"35"	"19"	"677"	"76.2"	"7.03"	"4776.99"	"84.31"	"13"	"18"	"DNA metabolism;stress response;developmental processes;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00400, Pf11816"	"57599"	"ENSG00000114742"	"WDR48"	"B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279"	"DNA repair pathways, full network"	"Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins"	"5"	"0"	"403.2"	"260.4"	"383.9"	"479.2"	"651.1"	"592.0"	"1901.2"	"2293.1"	"2637.6"	"5178.7"	"7868.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19338"	"Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3"	"30"	"29"	"59"	"29"	"710"	"76.6"	"4.70"	"9180.69"	"84.11"	"23"	"25"	"developmental processes;other biological processes"	"plasma membrane;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"4691"	"ENSG00000115053"	"NCL"	"hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1"	"Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling"	"Major pathway of rRNA processing in the nucleolus and cytosol"	"3"	"0"	"3841.5"	"2625.3"	"3701.3"	"4616.5"	"5256.5"	"4759.2"	"17318.4"	"14838.3"	"8560.6"	"9657.9"	"13700.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UQE7"	"Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2"	"22"	"26"	"53"	"26"	"1217"	"141.5"	"7.18"	"10534.98"	"84.05"	"24"	"24"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf02463, Pf06470"	"9126"	"ENSG00000108055"	"SMC3"	"A8K156; hsa:9126; O60464; Q5T482; Q9UQE7"	"Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Estrogen-dependent gene expression; SUMOylation of DNA damage response and repair proteins; Meiotic synapsis; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin"	"15"	"0"	"1084.8"	"641.3"	"1032.4"	"1218.2"	"1651.2"	"1370.6"	"7177.8"	"6519.9"	"4041.7"	"5672.6"	"7492.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P34897"	"Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3"	"39"	"18"	"45"	"17"	"504"	"56.0"	"8.53"	"7290.68"	"83.90"	"15"	"17"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00464"	"6472"	"ENSG00000182199"	"SHMT2"	"B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5"	"Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders"	"RHOG GTPase cycle; Metabolism of folate and pterines"	"11"	"1"	"1033.6"	"837.0"	"1138.0"	"1479.0"	"1678.0"	"1616.4"	"5227.7"	"4935.3"	"3683.0"	"4145.7"	"5340.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09874"	"Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4"	"23"	"21"	"50"	"21"	"1014"	"113.0"	"8.88"	"10009.77"	"83.76"	"20"	"19"	"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063"	"142"	"ENSG00000143799"	"PARP1"	"B1ANJ4; hsa:142; P09874; Q8IUZ9"	"Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; A network map of Macrophage-stimulating protein (MSP) signaling"	"SUMOylation of DNA damage response and repair proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER"	"25"	"0"	"449.0"	"244.3"	"401.1"	"500.5"	"711.6"	"565.3"	"4525.2"	"4678.7"	"3628.4"	"5921.1"	"11912.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23396"	"40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2"	"71"	"17"	"52"	"17"	"243"	"26.7"	"9.66"	"9646.11"	"82.89"	"15"	"16"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00189, Pf07650"	"6188"	"ENSG00000149273"	"RPS3"	"B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"1770.1"	"1126.8"	"1525.2"	"1911.8"	"2414.6"	"2062.9"	"6271.2"	"6016.9"	"3465.0"	"4240.1"	"6946.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14979"	"Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3"	"27"	"12"	"48"	"10"	"420"	"46.4"	"9.57"	"9888.40"	"82.82"	"12"	"11"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"nucleic acid binding activity"	"Pf00076"	"9987"	"ENSG00000152795"	"HNRNPDL"	"hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43"	""	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"	"1"	"0"	"570.2"	"366.3"	"587.0"	"782.5"	"1001.9"	"792.4"	"2055.1"	"1713.4"	"1100.8"	"1656.4"	"2119.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96CW1"	"AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2"	"43"	"17"	"45"	"17"	"435"	"49.6"	"9.54"	"8955.02"	"82.77"	"13"	"15"	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00928, Pf01217"	"1173"	"ENSG00000161203"	"AP2M1"	"A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1"	"Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling"	"Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; MHC class II antigen presentation; Nef Mediated CD4 Down-regulation; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions"	"21"	"0"	"310.6"	"205.7"	"314.0"	"398.3"	"527.4"	"446.8"	"1538.2"	"2957.3"	"4463.4"	"7471.5"	"9764.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62316"	"Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1"	"69"	"13"	"56"	"13"	"118"	"13.5"	"9.91"	"12165.01"	"82.62"	"12"	"12"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	""	"Pf01423"	"6633"	"ENSG00000125743"	"SNRPD2"	"A8K797; hsa:6633; J3KPM5; P43330; P62316"	"mRNA processing"	"mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway"	"5"	"0"	"1395.7"	"1012.1"	"1323.3"	"1513.5"	"1937.1"	"1666.0"	"5520.7"	"5155.7"	"2924.2"	"3619.7"	"4903.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P17844"	"Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1"	"37"	"27"	"60"	"20"	"614"	"69.1"	"8.92"	"11439.68"	"81.74"	"26"	"24"	"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf08061"	"1655"	"ENSG00000108654"	"DDX5"	"B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61"	"Ciliary landscape"	"mRNA Splicing - Major Pathway; SUMOylation of transcription cofactors; Estrogen-dependent gene expression; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome"	"6"	"0"	"2284.6"	"1330.3"	"1868.3"	"2384.4"	"3043.3"	"2551.9"	"7706.0"	"6234.4"	"3657.1"	"5331.6"	"7005.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P68363"	"Tubulin alpha-1B chain OS=Homo sapiens OX=9606 GN=TUBA1B PE=1 SV=1"	"40"	"14"	"42"	"1"	"451"	"50.1"	"5.06"	"7733.68"	"81.72"	"12"	"14"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00091, Pf03953"	"10376"	"ENSG00000123416"	"TUBA1B"	"hsa:10376; P04687; P05209; P68363; Q27I68; Q8WU19"	"Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; HCMV Early Events; RHO GTPases Activate Formins; Intraflagellar transport; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Hedgehog 'off' state; RHOH GTPase cycle"	"35"	"14"	"1825.5"	"1327.6"	"1766.9"	"2415.5"	"2894.3"	"2545.2"	"4034.4"	"3912.1"	"2321.8"	"3529.3"	"4257.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95602"	"DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2"	"17"	"21"	"44"	"21"	"1720"	"194.7"	"7.03"	"7458.24"	"81.69"	"17"	"20"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00623, Pf04983, Pf04997, Pf04998, Pf05000"	"25885"	"ENSG00000068654"	"POLR1A"	"B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9"	"Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination"	"8"	"0"	"415.4"	"278.7"	"424.4"	"616.0"	"794.1"	"670.8"	"1568.7"	"2985.0"	"3358.2"	"5244.9"	"6741.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25205"	"DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3"	"32"	"20"	"39"	"20"	"808"	"90.9"	"5.77"	"7370.00"	"80.17"	"17"	"18"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00493, Pf14551, Pf17207, Pf17855"	"4172"	"ENSG00000112118"	"MCM3"	"B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7"	"Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication"	"Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA"	"11"	"0"	"658.2"	"484.8"	"659.8"	"919.0"	"1188.4"	"1117.3"	"3549.8"	"3177.8"	"2144.2"	"2575.9"	"3397.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14152"	"Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1"	"22"	"32"	"61"	"32"	"1382"	"166.5"	"6.79"	"11875.83"	"78.93"	"31"	"25"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;translational apparatus;nucleus;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf01399"	"8661"	"ENSG00000107581"	"EIF3A"	"B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"8"	"0"	"2420.3"	"1557.7"	"2192.7"	"2494.5"	"3192.3"	"2725.7"	"6753.8"	"6210.6"	"3972.4"	"4779.3"	"6237.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07437"	"Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2"	"34"	"11"	"41"	"2"	"444"	"49.6"	"4.89"	"7210.90"	"77.26"	"10"	"11"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes"	"non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00091, Pf03953"	"203068"	"ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067"	"TUBB"	"hsa:203068; P05218; P07437; Q8WUC1; Q9CY33"	"Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease"	"Neutrophil degranulation; Potential therapeutics for SARS; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2"	"14"	"0"	"115.3"	"94.3"	"148.5"	"188.0"	"218.9"	"219.7"	"315.6"	"300.8"	"241.0"	"314.9"	"322.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P99999"	"Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2"	"65"	"10"	"46"	"10"	"105"	"11.7"	"9.57"	"10044.41"	"76.97"	"10"	"8"	"protein metabolism;other metabolic processes;signal transduction;other biological processes"	"other membranes;cytosol;mitochondrion;nucleus"	"other molecular function"	"Pf00034"	"54205"	"ENSG00000172115"	"CYCS"	"A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4"	"miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response"	"Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis"	"36"	"0"	"541.5"	"315.8"	"512.3"	"560.6"	"799.9"	"624.3"	"6480.5"	"6860.8"	"6115.8"	"6265.5"	"9391.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86XP3"	"ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1"	"25"	"20"	"44"	"20"	"938"	"102.9"	"7.02"	"8623.76"	"76.72"	"18"	"17"	"other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"11325"	"ENSG00000198231"	"DDX42"	"A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8"	""	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"2"	"0"	"828.9"	"674.4"	"928.7"	"1282.1"	"1518.1"	"1336.6"	"3832.8"	"3557.5"	"2827.7"	"3149.8"	"3806.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y450"	"HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1"	"31"	"17"	"39"	"17"	"684"	"75.4"	"6.61"	"7207.70"	"76.63"	"14"	"17"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00009, Pf03143, Pf03144, Pf08938"	"10767"	"ENSG00000112339"	"HBS1L"	"B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450"	""	"mRNA decay by 3' to 5' exoribonuclease"	"1"	"0"	"272.4"	"167.7"	"308.7"	"384.1"	"496.0"	"432.2"	"1870.8"	"3169.3"	"4276.1"	"6804.8"	"8770.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q71U36"	"Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1"	"40"	"14"	"40"	"1"	"451"	"50.1"	"5.06"	"7354.81"	"76.28"	"12"	"14"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00091, Pf03953"	"7846"	"ENSG00000167552"	"TUBA1A"	"A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36"	"Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation"	"COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; The role of GTSE1 in G2/M progression after G2 checkpoint; HCMV Early Events; Recycling pathway of L1; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of mitotic centrosome proteins and complexes; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate  to CCT/TriC; Hedgehog 'off' state; COPI-mediated anterograde transport; Intraflagellar transport; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Recruitment of NuMA to mitotic centrosomes; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2"	"41"	"0"	"30.3"	"16.4"	"23.0"	"43.7"	"41.9"	"40.0"	"61.4"	"58.8"	"25.6"	"39.3"	"60.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13435"	"Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2"	"22"	"21"	"41"	"21"	"895"	"100.2"	"5.67"	"7537.73"	"75.89"	"20"	"19"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf02037, Pf04037, Pf04046"	"10992"	"ENSG00000087365"	"SF3B2"	"A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"1084.3"	"608.8"	"960.9"	"1256.5"	"1634.5"	"1370.1"	"4268.2"	"3683.8"	"2273.7"	"3301.7"	"4117.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60891"	"Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2"	"45"	"15"	"49"	"7"	"318"	"34.8"	"6.98"	"8755.19"	"75.38"	"14"	"13"	"other metabolic processes;developmental processes"	"cytosol;other cell component"	"kinase activity;other molecular function"	"Pf13793, Pf14572"	"5631"	"ENSG00000147224"	"PRPS1"	"B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891"	""	"5-Phosphoribose 1-diphosphate biosynthesis"	"1"	"13"	"1435.8"	"1252.2"	"1503.7"	"2356.2"	"2672.6"	"2423.4"	"4239.2"	"4437.2"	"3021.0"	"3229.3"	"3326.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P68371"	"Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1"	"34"	"11"	"41"	"2"	"445"	"49.8"	"4.89"	"7227.77"	"75.12"	"10"	"11"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response"	"non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00091, Pf03953"	"10383"	"ENSG00000188229"	"TUBB4B"	"A2BFA2; hsa:10383; P05217; P68371"	"Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate  to CCT/TriC; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Recycling pathway of L1; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Post-chaperonin tubulin folding pathway; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Hedgehog 'off' state"	"41"	"13"	"863.5"	"695.2"	"918.9"	"1267.2"	"1463.1"	"1235.6"	"2248.3"	"2143.9"	"1393.0"	"1980.1"	"2234.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62736"	"Actin, aortic smooth muscle OS=Homo sapiens OX=9606 GN=ACTA2 PE=1 SV=1"	"30"	"14"	"49"	"1"	"377"	"42.0"	"5.39"	"10225.94"	"75.12"	"12"	"13"	"developmental processes;other biological processes"	"extracellular matrix;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00022"	"59"	"ENSG00000107796"	"ACTA2"	"B2R8A4; hsa:59; P03996; P04108; P62736; Q6FI19"	"Myometrial relaxation and contraction pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; Urotensin-II-mediated signaling pathway; Markers of kidney cell lineage; Comprehensive IL-17A signaling; IL-26 signaling pathways; A network map of Macrophage-stimulating protein (MSP) signaling"	"Smooth Muscle Contraction; NOTCH4 Intracellular Domain Regulates Transcription"	"16"	"0"	"90.0"	"60.8"	"90.4"	"98.1"	"126.5"	"118.4"	"267.5"	"200.8"	"165.1"	"240.8"	"254.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P24928"	"DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2"	"17"	"24"	"42"	"24"	"1970"	"217.0"	"7.37"	"7542.53"	"74.58"	"19"	"21"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001"	"5430"	""	"POLR2A"	"A6NN93; B9EH88; hsa:5430; P24928; Q6NX41"	"Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing"	"mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"44"	"0"	"855.3"	"584.2"	"846.1"	"1081.4"	"1322.3"	"1158.7"	"2809.9"	"2759.1"	"1722.2"	"2186.9"	"2564.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q00610"	"Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5"	"14"	"19"	"39"	"19"	"1675"	"191.5"	"5.69"	"7010.96"	"74.32"	"16"	"18"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf00637, Pf01394, Pf09268, Pf13838"	"1213"	"ENSG00000141367"	"CLTC"	"D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2"	"Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades"	"Recycling pathway of L1; MHC class II antigen presentation; ALK mutants bind TKIs; Nuclear events stimulated by ALK signaling in cancer; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions"	"25"	"0"	"1273.4"	"959.2"	"1333.7"	"1685.2"	"2063.1"	"1737.9"	"2396.9"	"2144.7"	"1377.6"	"1815.8"	"2508.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63104"	"14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 GN=YWHAZ PE=1 SV=1"	"62"	"14"	"44"	"12"	"245"	"27.7"	"4.79"	"8101.44"	"74.30"	"12"	"14"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00244"	"7534"	"ENSG00000164924"	"YWHAZ"	"A8K1N0; B7Z465; hsa:7534; P29213; P29312; P63104; Q32P43; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33"	"Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways"	"RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Negative regulation of NOTCH4 signaling; Deactivation of the beta-catenin transactivating complex; Interleukin-3, Interleukin-5 and GM-CSF signaling; TP53 Regulates Metabolic Genes; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; Activation of BAD and translocation to mitochondria"	"23"	"0"	"1230.0"	"800.4"	"1497.2"	"2153.0"	"2409.5"	"2248.7"	"4383.5"	"4555.7"	"2436.4"	"3197.3"	"4378.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55795"	"Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1"	"36"	"12"	"38"	"5"	"449"	"49.2"	"6.30"	"7068.01"	"74.13"	"10"	"11"	"other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf00076, Pf08080"	"3188"	"ENSG00000126945"	"HNRNPH2"	"A1L400; hsa:3188; P55795; Q9HHA7"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"3"	"0"	"201.9"	"141.1"	"260.1"	"404.3"	"431.5"	"370.1"	"828.5"	"796.1"	"421.6"	"591.3"	"701.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UQ80"	"Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3"	"44"	"17"	"48"	"17"	"394"	"43.8"	"6.55"	"8603.96"	"73.52"	"17"	"16"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00557"	"5036"	"ENSG00000170515"	"PA2G4"	"hsa:5036; O43846; Q9UM59; Q9UQ80"	""	"Neutrophil degranulation"	"1"	"0"	"1038.3"	"656.5"	"1052.9"	"1246.8"	"1560.2"	"1402.0"	"5460.3"	"5243.3"	"3071.5"	"4017.9"	"5991.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P68104"	"Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1"	"26"	"14"	"43"	"8"	"462"	"50.1"	"9.01"	"6907.32"	"72.24"	"12"	"12"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00009, Pf03143, Pf03144"	"1915"	"ENSG00000156508"	"EEF1A1"	"hsa:1915; P04719; P04720; P68104; Q6IQ15"	"Translation factors; Fragile X syndrome; 2q37 copy number variation syndrome"	"Chaperone Mediated Autophagy; Peptide chain elongation; SARS-CoV-1 modulates host translation machinery; Neutrophil degranulation; Protein methylation; HSF1 activation"	"10"	"9"	"1917.2"	"1387.3"	"1761.7"	"2461.0"	"3029.7"	"2755.2"	"8937.1"	"8625.8"	"6674.0"	"7872.5"	"10036.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49407"	"Beta-arrestin-1 OS=Homo sapiens OX=9606 GN=ARRB1 PE=1 SV=2"	"42"	"14"	"40"	"11"	"418"	"47.0"	"6.20"	"6551.99"	"70.76"	"13"	"14"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00339, Pf02752"	"408"	"ENSG00000137486"	"ARRB1"	"B6V9G8; hsa:408; O75625; O75630; P49407; Q2PP20; Q9BTK8"	"Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; MAPK signaling pathway; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells"	"Ub-specific processing proteases; Activation of SMO; Activated NOTCH1 Transmits Signal to the Nucleus; G alpha (s) signalling events; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Cargo recognition for clathrin-mediated endocytosis; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants"	"25"	"0"	"101.9"	"74.8"	"105.3"	"156.1"	"195.4"	"205.4"	"827.3"	"1605.1"	"1762.2"	"2586.3"	"3461.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61981"	"14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2"	"53"	"13"	"46"	"8"	"247"	"28.3"	"4.89"	"8612.79"	"70.73"	"11"	"13"	"transport;signal transduction;other biological processes"	"cytosol;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00244"	"7532"	"ENSG00000170027"	"YWHAG"	"hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99"	"Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria"	"21"	"0"	"414.1"	"315.6"	"455.6"	"599.1"	"705.6"	"636.1"	"1404.1"	"1412.5"	"1048.7"	"1155.7"	"1309.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26599"	"Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1"	"40"	"13"	"36"	"11"	"531"	"57.2"	"9.17"	"6277.85"	"70.28"	"7"	"13"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076, Pf11835, Pf13893"	"749887"	"ENSPPYG00000009289; ENSPTRG00000010165"	"PTBP1"	"A0A2J8IKP3; A0A2J8RA51; A0A6D2WFY9; A0A8I5YPF9; K7AXA8"	""	""	"0"	"3"	"862.6"	"636.4"	"858.7"	"1255.1"	"1596.0"	"1347.9"	"4968.7"	"4327.8"	"3159.1"	"3558.2"	"4812.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14678"	"Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2"	"22"	"8"	"28"	"8"	"240"	"24.6"	"11.19"	"2917.97"	"70.01"	"4"	"8"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01423"	"6628"	"ENSG00000125835"	"SNRPB"	"hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5"	"mRNA processing"	"snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"	"8"	"0"	"811.1"	"527.0"	"735.3"	"845.2"	"1003.4"	"884.3"	"2824.6"	"2780.3"	"1738.9"	"2210.9"	"3028.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13838"	"Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1"	"33"	"14"	"45"	"6"	"428"	"49.0"	"5.67"	"9055.21"	"69.55"	"14"	"11"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"7919"	"ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439"	"DDX39B"	"B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76"	""	"mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; RHOBTB2 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"5"	"8"	"1117.8"	"778.2"	"1084.1"	"1551.3"	"2054.0"	"1735.1"	"3458.5"	"3172.0"	"1994.5"	"2481.7"	"3016.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99729"	"Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2"	"34"	"14"	"49"	"12"	"332"	"36.2"	"8.21"	"7951.15"	"68.92"	"12"	"12"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf08143"	"3182"	"ENSG00000197451"	"HNRNPAB"	"B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99"	"Pre-implantation embryo; mRNA processing"	""	"2"	"0"	"1384.4"	"971.6"	"1374.1"	"1884.6"	"2201.3"	"1950.0"	"4963.5"	"4018.7"	"2620.6"	"3710.6"	"5193.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62318"	"Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1"	"54"	"6"	"32"	"6"	"126"	"13.9"	"10.32"	"7494.26"	"68.70"	"5"	"4"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01423"	"6634"	"ENSG00000100028"	"SNRPD3"	"B4DJP7; B5BU13; hsa:6634; P43331; P62318"	"mRNA processing"	"mRNA Splicing - Major Pathway; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"	"8"	"0"	"790.2"	"640.5"	"779.0"	"831.0"	"975.5"	"882.9"	"2686.5"	"2532.5"	"1730.1"	"2060.1"	"2330.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P00367"	"Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2"	"37"	"17"	"39"	"17"	"558"	"61.4"	"7.80"	"6253.85"	"68.35"	"14"	"16"	"other metabolic processes;other biological processes"	"mitochondrion;ER/Golgi;other cell component"	"other molecular function"	"Pf00208, Pf02812"	"2746"	"ENSG00000148672"	"GLUD1"	"B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3"	"VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation"	"Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism"	"8"	"0"	"1534.6"	"1026.3"	"1524.1"	"1880.4"	"2148.8"	"2068.0"	"3218.7"	"3244.6"	"2081.3"	"2579.2"	"3615.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q1KMD3"	"Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1"	"28"	"18"	"34"	"18"	"747"	"85.1"	"4.91"	"5778.37"	"66.83"	"15"	"17"	""	"nucleus;other cell component"	""	"Pf00622, Pf02037, Pf13671"	"221092"	"ENSG00000214753"	"HNRNPUL2"	"hsa:221092; Q1KMD3; Q8N3B3"	""	""	"0"	"0"	"2110.2"	"1485.7"	"2058.5"	"2536.8"	"2986.2"	"2932.8"	"4300.8"	"3819.5"	"2245.1"	"3361.0"	"5165.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12956"	"X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2"	"37"	"21"	"42"	"21"	"609"	"69.8"	"6.64"	"7910.50"	"66.11"	"17"	"18"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02037, Pf02735, Pf03730, Pf03731"	"2547"	"ENSG00000196419"	"XRCC6"	"B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3"	"Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency"	"Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN"	"8"	"0"	"1152.6"	"698.7"	"1112.8"	"1436.0"	"1803.8"	"1681.2"	"4536.0"	"4409.8"	"2726.8"	"3365.2"	"4904.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50990"	"T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4"	"36"	"19"	"38"	"19"	"548"	"59.6"	"5.60"	"7400.59"	"65.72"	"17"	"17"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00118"	"10694"	"ENSG00000156261"	"CCT8"	"A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8"	"16p11.2 proximal deletion syndrome"	"Neutrophil degranulation; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC"	"8"	"0"	"1141.0"	"881.7"	"1204.6"	"1694.1"	"1905.9"	"1812.0"	"2853.3"	"2789.4"	"1811.0"	"2343.7"	"3364.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92804"	"TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1"	"22"	"8"	"27"	"5"	"592"	"61.8"	"8.02"	"3203.68"	"65.56"	"5"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf00641"	"8148"	"ENSG00000270647; ENSG00000276833"	"TAF15"	"B2R837; hsa:8148; Q86X94; Q92751; Q92804"	"17q12 copy number variation syndrome"	"Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation"	"10"	"0"	"268.0"	"193.7"	"290.4"	"321.3"	"350.9"	"302.9"	"944.3"	"860.1"	"593.2"	"674.9"	"651.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07900"	"Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5"	"28"	"19"	"41"	"9"	"732"	"84.6"	"5.02"	"6730.73"	"65.12"	"15"	"17"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00183, Pf02518"	"3320"	"ENSG00000080824"	"HSP90AA1"	"A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5"	"Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway"	"Neutrophil degranulation; Estrogen-dependent gene expression; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; vRNP Assembly; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants"	"67"	"0"	"479.8"	"330.0"	"470.7"	"696.8"	"871.1"	"790.1"	"1211.8"	"1173.7"	"622.2"	"1073.5"	"1552.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P17987"	"T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1"	"44"	"18"	"32"	"18"	"556"	"60.3"	"6.11"	"5477.55"	"65.06"	"14"	"16"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;other cell component"	"other molecular function"	"Pf00118"	"6950"	"ENSG00000120438"	"TCP1"	"E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3"	"16p11.2 proximal deletion syndrome"	"Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC"	"8"	"0"	"1086.2"	"712.7"	"1181.1"	"1617.5"	"1868.7"	"1755.9"	"2696.9"	"2671.9"	"1585.4"	"2172.4"	"2854.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13010"	"X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3"	"30"	"16"	"31"	"16"	"732"	"82.7"	"5.81"	"5367.62"	"63.92"	"12"	"15"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf02735, Pf03730, Pf03731, Pf08785"	"7520"	"ENSG00000079246"	"XRCC5"	"A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1"	"Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network"	"Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN"	"9"	"0"	"693.4"	"398.6"	"591.9"	"766.3"	"908.7"	"848.8"	"2305.8"	"2187.0"	"1330.2"	"1718.2"	"2313.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BXP5"	"Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1"	"23"	"21"	"37"	"21"	"876"	"100.6"	"5.96"	"6473.21"	"63.14"	"18"	"19"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04959, Pf12066"	"51593"	"ENSG00000087087"	"SRRT"	"A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4"	""	"mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes"	"2"	"0"	"1425.2"	"927.6"	"1366.8"	"2182.1"	"2644.6"	"2169.3"	"5622.1"	"5122.2"	"2723.2"	"3648.3"	"4700.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P40926"	"Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3"	"49"	"14"	"42"	"14"	"338"	"35.5"	"8.68"	"7323.93"	"62.64"	"14"	"13"	"other metabolic processes"	"other membranes;mitochondrion;other cell component"	"other molecular function"	"Pf00056, Pf02866"	"4191"	"ENSG00000146701"	"MDH2"	"A8K414; B2RE78; B4DE44; E9PDB2; hsa:4191; O43682; P40926"	"Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)"	"Gluconeogenesis; Citric acid cycle (TCA cycle)"	"8"	"0"	"1447.8"	"949.6"	"1438.1"	"1943.9"	"2223.2"	"2277.4"	"4476.8"	"4499.1"	"3013.1"	"3636.4"	"6754.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96P16"	"Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1"	"54"	"14"	"35"	"12"	"312"	"35.7"	"7.55"	"5730.62"	"62.58"	"10"	"13"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"other molecular function"	"Pf04818, Pf16566"	"55197"	"ENSG00000141425"	"RPRD1A"	"A8KA42; B2RBA3; hsa:55197; Q7Z5G8; Q96FY9; Q96P16; Q9NVL4"	""	"RNA polymerase II transcribes snRNA genes"	"1"	"1"	"521.5"	"353.4"	"565.9"	"799.3"	"1122.3"	"848.9"	"6345.0"	"6208.0"	"3903.0"	"5043.0"	"6266.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q06830"	"Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1"	"49"	"13"	"41"	"12"	"199"	"22.1"	"8.13"	"7952.79"	"62.19"	"13"	"11"	"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00578, Pf10417"	"5052"	"ENSG00000117450"	"PRDX1"	"B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155"	"Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway"	"Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"	"8"	"1"	"1197.3"	"953.8"	"1185.3"	"1698.7"	"2164.3"	"1941.4"	"4026.1"	"4008.2"	"3278.3"	"3486.8"	"4950.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09651"	"Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5"	"31"	"12"	"47"	"10"	"372"	"38.7"	"9.13"	"9705.63"	"62.02"	"11"	"10"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf11627"	"3178"	"ENSG00000135486"	"HNRNPA1"	"A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7"	"mRNA processing"	"mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery"	"6"	"0"	"1311.1"	"1162.1"	"1425.4"	"1657.4"	"1976.7"	"1701.3"	"4678.8"	"4119.7"	"3540.5"	"3865.3"	"4801.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UMS4"	"Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1"	"35"	"12"	"29"	"12"	"504"	"55.1"	"6.61"	"4014.02"	"61.37"	"8"	"12"	"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00400, Pf04564, Pf08606"	"27339"	"ENSG00000110107"	"PRPF19"	"hsa:27339; Q9UMS4"	""	"mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex"	"5"	"0"	"644.0"	"404.1"	"583.1"	"803.4"	"1013.4"	"904.6"	"3103.3"	"3219.6"	"1885.8"	"2638.0"	"4099.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P57772"	"Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4"	"28"	"14"	"35"	"14"	"596"	"65.3"	"8.35"	"6510.34"	"60.99"	"13"	"14"	"protein metabolism;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00009"	"60678"	"ENSG00000132394; ENSG00000284869"	"EEFSEC"	"hsa:60678; P57772; Q96HZ6"	""	"Selenocysteine synthesis"	"1"	"0"	"284.7"	"189.1"	"292.3"	"374.4"	"471.9"	"424.5"	"2727.9"	"5666.4"	"4296.2"	"5249.6"	"6471.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26368"	"Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4"	"31"	"11"	"30"	"11"	"475"	"53.5"	"9.09"	"4722.58"	"60.78"	"9"	"10"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"11338"	"ENSG00000063244"	"U2AF2"	"hsa:11338; P26368; Q96HC5"	"mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates"	"mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"6"	"0"	"1169.7"	"763.0"	"1142.5"	"1545.7"	"1890.5"	"1808.9"	"6538.3"	"6139.6"	"2726.6"	"3763.5"	"5235.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P33992"	"DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5"	"25"	"16"	"39"	"16"	"734"	"82.2"	"8.37"	"7168.89"	"60.72"	"15"	"15"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00493, Pf14551, Pf17207, Pf17855"	"4174"	"ENSG00000100297"	"MCM5"	"hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8"	"Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication"	"Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA"	"10"	"0"	"647.9"	"490.2"	"649.4"	"894.3"	"1137.1"	"1063.5"	"3370.5"	"3166.6"	"2081.4"	"2656.1"	"3709.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P34932"	"Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4"	"27"	"21"	"40"	"19"	"840"	"94.3"	"5.19"	"7297.97"	"60.57"	"17"	"19"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport"	"non-structural extracellular;cytosol;mitochondrion;nucleus"	"other molecular function"	"Pf00012"	"3308"	"ENSG00000170606"	"HSPA4"	"hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9"	"Parkin-ubiquitin proteasomal system pathway"	"Regulation of HSF1-mediated heat shock response"	"2"	"2"	"1473.4"	"974.8"	"1489.4"	"2142.2"	"2542.8"	"2407.0"	"4078.5"	"4112.6"	"2579.9"	"3286.9"	"5037.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08865"	"40S ribosomal protein SA OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4"	"52"	"13"	"25"	"13"	"295"	"32.8"	"4.87"	"4126.86"	"60.11"	"9"	"11"	"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component"	"translation activity;other molecular function"	"Pf00318, Pf16122"	"3921"	"ENSG00000168028"	"RPSA"	"hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"895.7"	"622.0"	"889.3"	"963.2"	"1130.7"	"1013.5"	"3689.3"	"3573.8"	"2244.3"	"2729.6"	"2535.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14697"	"Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3"	"21"	"15"	"31"	"15"	"944"	"106.8"	"6.14"	"4564.32"	"60.03"	"11"	"14"	"protein metabolism;other metabolic processes"	"ER/Golgi;other cell component"	"other molecular function"	"Pf01055, Pf13802"	"23193"	"ENSG00000089597"	"GANAB"	"A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0"	"N-glycan biosynthesis"	"Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein"	"5"	"0"	"656.0"	"550.5"	"722.0"	"1026.6"	"1156.0"	"1150.8"	"2066.8"	"2272.6"	"1631.8"	"2279.6"	"3857.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11021"	"Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2"	"30"	"19"	"39"	"16"	"654"	"72.3"	"5.16"	"7826.35"	"59.97"	"17"	"17"	"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component"	"translation activity;other molecular function"	"Pf00012"	"3309"	"ENSG00000044574"	"HSPA5"	"B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02"	"Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway"	"Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes"	"14"	"0"	"1319.3"	"910.0"	"1448.1"	"1918.5"	"2249.7"	"2126.8"	"3890.7"	"3904.2"	"2337.0"	"3183.0"	"4804.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15371"	"Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1"	"29"	"13"	"29"	"13"	"548"	"63.9"	"6.05"	"4100.04"	"58.61"	"11"	"12"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity"	"Pf05091"	"8664"	"ENSG00000100353"	"EIF3D"	"A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6"	"Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"9"	"0"	"718.1"	"407.7"	"610.9"	"872.0"	"1113.0"	"974.0"	"2459.1"	"2343.9"	"1256.4"	"1605.4"	"2280.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P00558"	"Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3"	"36"	"13"	"21"	"13"	"417"	"44.6"	"8.10"	"2909.70"	"58.13"	"4"	"13"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;other membranes;cytosol"	"kinase activity;other molecular function"	"Pf00162"	"5230"	"ENSG00000102144"	"PGK1"	"A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87"	"Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism"	"13"	"0"	"482.8"	"343.9"	"449.2"	"581.0"	"695.5"	"804.0"	"1261.9"	"1348.2"	"1412.3"	"3597.1"	"12448.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99613"	"Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1"	"19"	"16"	"34"	"16"	"913"	"105.3"	"5.68"	"7192.57"	"58.10"	"15"	"12"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf01399, Pf05470"	"8663"	"ENSG00000184110"	"EIF3C"	"A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"8"	"0"	"962.7"	"677.0"	"892.3"	"1070.9"	"1308.7"	"1121.6"	"2760.2"	"2514.1"	"1522.6"	"1750.9"	"2611.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96EK5"	"KIF-binding protein OS=Homo sapiens OX=9606 GN=KIFBP PE=1 SV=1"	"26"	"12"	"26"	"12"	"621"	"71.8"	"5.49"	"4847.10"	"56.76"	"9"	"12"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes"	"cytoskeleton;mitochondrion"	"cytoskeletal activity"	"Pf12309"	"26128"	"ENSG00000198954"	"KIFBP"	"A8K5M8; hsa:26128; Q96EK5; Q9BR89; Q9ULE1; Q9Y428"	""	""	"0"	"0"	"232.6"	"142.4"	"231.0"	"309.0"	"382.0"	"323.7"	"769.5"	"1422.8"	"2490.5"	"4715.8"	"7215.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05455"	"Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2"	"47"	"19"	"40"	"19"	"408"	"46.8"	"7.12"	"7721.70"	"56.24"	"18"	"16"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf05383, Pf08777"	"6741"	"ENSG00000138385"	"SSB"	"hsa:6741; P05455; Q15367; Q53XJ4"	""	"RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination"	"2"	"0"	"1569.1"	"968.1"	"1446.3"	"1875.8"	"2245.2"	"2110.9"	"5678.3"	"5453.6"	"3300.3"	"4135.5"	"6689.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96DI7"	"U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1"	"33"	"11"	"29"	"11"	"357"	"39.3"	"8.10"	"6121.05"	"55.85"	"11"	"11"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	""	"Pf00400"	"9410"	"ENSG00000060688"	"SNRNP40"	"B4DQJ1; hsa:9410; O75938; O95320; Q96DI7"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"733.9"	"449.6"	"660.7"	"775.8"	"965.6"	"850.3"	"2523.5"	"2503.8"	"1782.3"	"2698.8"	"4055.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30876"	"DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1"	"20"	"19"	"32"	"19"	"1174"	"133.8"	"6.87"	"5193.38"	"55.72"	"14"	"18"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567"	"5431"	"ENSG00000047315"	"POLR2B"	"A8K1A8; hsa:5431; P30876; Q8IZ61"	"Pyrimidine metabolism; Eukaryotic transcription initiation"	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; PIWI-interacting RNA (piRNA) biogenesis; mRNA Splicing - Minor Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"43"	"0"	"942.1"	"640.4"	"803.9"	"1085.5"	"1314.8"	"1129.3"	"2978.4"	"2914.3"	"1940.6"	"2287.1"	"2746.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49736"	"DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4"	"19"	"15"	"34"	"15"	"904"	"101.8"	"5.52"	"5906.87"	"55.62"	"14"	"13"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00493, Pf12619, Pf14551, Pf17207, Pf17855"	"4171"	"ENSG00000073111"	"MCM2"	"hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7"	"Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome"	"Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA"	"11"	"0"	"876.8"	"704.4"	"893.2"	"1230.2"	"1471.0"	"1454.1"	"2386.8"	"2207.9"	"1485.7"	"1992.2"	"2499.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31948"	"Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1"	"31"	"17"	"34"	"17"	"543"	"62.6"	"6.80"	"5342.97"	"55.40"	"14"	"17"	"other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00515, Pf13181, Pf17830"	"10963"	"ENSG00000168439"	"STIP1"	"B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9"	"VEGFA-VEGFR2 signaling"	"HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle"	"3"	"0"	"1110.8"	"746.7"	"1122.7"	"1794.8"	"2275.9"	"1966.0"	"4052.2"	"3935.7"	"2509.0"	"3373.6"	"4066.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15020"	"Spectrin beta chain, non-erythrocytic 2 OS=Homo sapiens OX=9606 GN=SPTBN2 PE=1 SV=3"	"8"	"16"	"33"	"10"	"2390"	"271.2"	"6.11"	"6116.89"	"55.08"	"16"	"15"	"cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf00435, Pf15410"	"6712"	"ENSG00000173898"	"SPTBN2"	"hsa:6712; O14872; O14873; O15020"	""	"MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins"	"5"	"0"	"143.5"	"111.1"	"153.4"	"224.1"	"270.9"	"235.5"	"600.6"	"611.9"	"392.9"	"598.9"	"846.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86YQ8"	"Copine-8 OS=Homo sapiens OX=9606 GN=CPNE8 PE=1 SV=2"	"32"	"16"	"35"	"15"	"564"	"63.1"	"5.96"	"6353.44"	"54.83"	"14"	"16"	"other biological processes"	"plasma membrane;other membranes"	"other molecular function"	"Pf00168, Pf07002"	"144402"	"ENSG00000139117"	"CPNE8"	"hsa:144402; Q2TB41; Q86VY2; Q86YQ8"	""	"RHOD GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle"	"4"	"1"	"699.9"	"510.2"	"749.8"	"1001.3"	"1051.7"	"1086.4"	"3170.5"	"3543.3"	"2076.9"	"2698.2"	"3597.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09661"	"U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2"	"45"	"17"	"42"	"17"	"255"	"28.4"	"8.62"	"7808.20"	"54.52"	"15"	"12"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf14580"	"6627"	"ENSG00000131876"	"SNRPA1"	"B2R5I6; hsa:6627; P09661; Q8TBD2"	"mRNA processing"	"mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"	"3"	"0"	"2067.2"	"1543.8"	"1996.8"	"2105.9"	"2681.0"	"2535.4"	"6081.9"	"5826.8"	"4308.6"	"4763.5"	"6878.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P24534"	"Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3"	"69"	"14"	"33"	"12"	"225"	"24.7"	"4.67"	"6660.10"	"54.47"	"11"	"11"	"protein metabolism;other metabolic processes"	"cytosol;other cell component"	"enzyme regulator activity;nucleic acid binding activity"	"Pf00736, Pf10587"	"1933"	"ENSG00000114942; ENSG00000283391"	"EEF1B2"	"A8K795; hsa:1933; P24534; Q6IBH9"	"Translation factors"	"Eukaryotic Translation Elongation"	"2"	"3"	"1503.2"	"990.0"	"1450.5"	"2052.5"	"2496.1"	"2241.0"	"5606.2"	"5687.1"	"3962.4"	"4695.8"	"5720.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92499"	"ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2"	"23"	"14"	"30"	"14"	"740"	"82.4"	"7.23"	"5745.63"	"54.44"	"13"	"13"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf00622"	"1653"	"ENSG00000079785"	"DDX1"	"B4DME8; B4DPN6; hsa:1653; Q92499"	"DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing"	"tRNA processing in the nucleus"	"3"	"0"	"473.6"	"283.6"	"436.0"	"541.6"	"700.9"	"551.6"	"2107.6"	"1931.9"	"1268.8"	"1628.6"	"2145.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63244"	"Receptor of activated protein C kinase 1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3"	"44"	"14"	"36"	"14"	"317"	"35.1"	"7.69"	"6192.08"	"53.93"	"13"	"14"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function"	"Pf00400"	"10399"	"ENSG00000204628"	"RACK1"	"B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47"	"Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways"	"Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production"	"10"	"0"	"1256.6"	"827.2"	"1233.7"	"1484.7"	"1739.9"	"1555.6"	"5286.2"	"4877.4"	"2873.9"	"3596.9"	"4932.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2W1"	"Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2"	"20"	"18"	"36"	"18"	"955"	"108.6"	"10.15"	"6898.19"	"53.70"	"16"	"15"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf15440"	"9967"	"ENSG00000054118"	"THRAP3"	"D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1"	"Interactome of polycomb repressive complex 2 (PRC2)"	"PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation"	"3"	"0"	"1310.5"	"860.5"	"1097.1"	"1335.4"	"1829.5"	"1591.3"	"4849.2"	"4095.2"	"2548.7"	"3892.1"	"4386.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12874"	"Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1"	"32"	"15"	"32"	"14"	"501"	"58.8"	"5.38"	"6268.23"	"53.31"	"13"	"12"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf11931, Pf12108, Pf13297, Pf16837"	"10946"	"ENSG00000183431"	"SF3A3"	"D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87"	"Exercise-induced circadian regulation; mRNA processing"	"mRNA Splicing - Major Pathway"	"3"	"1"	"1594.7"	"960.1"	"1581.3"	"2134.6"	"2614.5"	"2222.7"	"6315.2"	"5815.9"	"3286.9"	"4121.2"	"5766.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P27348"	"14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1"	"36"	"9"	"29"	"6"	"245"	"27.7"	"4.78"	"5112.21"	"53.07"	"8"	"9"	"transport;signal transduction;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00244"	"10971"	"ENSG00000134308"	"YWHAQ"	"D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48"	"Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways"	"TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria"	"20"	"0"	"491.5"	"275.3"	"491.3"	"714.8"	"801.3"	"741.3"	"1394.2"	"1390.8"	"836.9"	"1092.2"	"1461.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6P1J9"	"Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1"	"35"	"16"	"30"	"16"	"531"	"60.5"	"9.61"	"4843.34"	"52.89"	"14"	"15"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf05179, Pf16050"	"79577"	"ENSG00000134371"	"CDC73"	"A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7"	"Endoderm differentiation"	"Hedgehog 'on' state; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events"	"7"	"0"	"774.0"	"505.5"	"755.8"	"944.8"	"1214.6"	"1052.8"	"4809.3"	"4572.3"	"2899.6"	"3747.7"	"5013.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NSD9"	"Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3"	"30"	"17"	"32"	"17"	"589"	"66.1"	"6.84"	"5335.84"	"52.88"	"14"	"16"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03483, Pf03484, Pf17759, Pf18262"	"10056"	"ENSG00000116120"	"FARSB"	"B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6"	"VEGFA-VEGFR2 signaling; Amino acid metabolism"	"Cytosolic tRNA aminoacylation"	"3"	"0"	"760.5"	"479.1"	"798.6"	"898.8"	"1161.2"	"1005.0"	"5889.0"	"5502.9"	"3453.3"	"4525.5"	"5311.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q04917"	"14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4"	"39"	"10"	"32"	"7"	"246"	"28.2"	"4.84"	"4761.61"	"52.75"	"9"	"10"	"other metabolic processes;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00244"	"7533"	"ENSG00000128245"	"YWHAH"	"hsa:7533; Q04917"	"Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria"	"11"	"0"	"337.6"	"241.2"	"361.0"	"512.9"	"639.6"	"614.6"	"1174.3"	"1287.1"	"781.7"	"1006.6"	"1268.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P53396"	"ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3"	"16"	"16"	"33"	"16"	"1101"	"120.8"	"7.33"	"5858.49"	"52.73"	"15"	"14"	"other metabolic processes"	"non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00285, Pf00549, Pf02629, Pf16114"	"47"	"ENSG00000131473"	"ACLY"	"B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0"	"Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer"	"Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis"	"10"	"0"	"1215.8"	"807.3"	"1115.5"	"1465.5"	"1796.1"	"1733.8"	"3672.0"	"3627.0"	"2285.9"	"2913.0"	"4324.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P38159"	"RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3"	"28"	"9"	"36"	"4"	"391"	"42.3"	"10.05"	"6578.95"	"52.34"	"8"	"9"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"non-structural extracellular;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf08081"	"27316"	"ENSG00000147274"	"RBMX"	"B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle"	"8"	"5"	"1368.0"	"967.3"	"1130.0"	"1395.5"	"1862.7"	"1592.2"	"4976.1"	"3810.0"	"2551.2"	"3931.0"	"4994.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26641"	"Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3"	"31"	"15"	"39"	"15"	"437"	"50.1"	"6.67"	"6955.41"	"52.31"	"15"	"13"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;other cell component"	"nucleic acid binding activity"	"Pf00043, Pf00647, Pf02798"	"1937"	"ENSG00000254772"	"EEF1G"	"B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196"	"Translation factors"	"Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation"	"3"	"0"	"1120.4"	"831.8"	"1337.9"	"2411.8"	"2807.3"	"2376.3"	"6237.9"	"6200.7"	"3473.8"	"4352.0"	"5068.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P0DP25"	"Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1"	"49"	"9"	"33"	"9"	"149"	"16.8"	"4.22"	"6079.98"	"52.00"	"8"	"9"	"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf13499"	"801; 805; 808"	"ENSG00000160014"	"CALM3"	"hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3"	"Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells"	""	"17"	"0"	"695.4"	"590.2"	"778.9"	"977.0"	"1081.6"	"1051.0"	"2641.2"	"2934.8"	"2507.5"	"3268.7"	"4388.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q07666"	"KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1"	"19"	"12"	"29"	"12"	"443"	"48.2"	"8.66"	"5613.74"	"51.76"	"9"	"10"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf16274, Pf16568"	"10657"	"ENSG00000121774"	"KHDRBS1"	"D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760"	"Leptin signaling pathway; Primary ovarian insufficiency"	"PTK6 Regulates Proteins Involved in RNA Processing"	"3"	"0"	"1602.2"	"1021.4"	"1539.8"	"1797.8"	"2216.2"	"1779.8"	"4619.6"	"4181.4"	"2888.2"	"3201.1"	"4817.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q53GS9"	"U4/U6.U5 tri-snRNP-associated protein 2 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2"	"30"	"14"	"28"	"13"	"565"	"65.3"	"8.91"	"5379.44"	"51.35"	"13"	"14"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf00443, Pf02148"	"10713"	"ENSG00000168883"	"USP39"	"A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310"	""	"mRNA Splicing - Major Pathway"	"1"	"1"	"349.5"	"202.0"	"332.8"	"378.3"	"525.0"	"416.5"	"2419.2"	"2237.9"	"1496.9"	"2201.7"	"3059.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NC51"	"Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2"	"40"	"16"	"36"	"16"	"408"	"44.9"	"8.65"	"8261.44"	"51.23"	"14"	"13"	"cell organization and biogenesis;other biological processes"	"cytosol;nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf04774, Pf16174"	"26135"	"ENSG00000142864"	"SERBP1"	"hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3"	"Apoptosis-related network due to altered Notch3 in ovarian cancer"	""	"1"	"0"	"1716.6"	"923.5"	"1402.7"	"1555.2"	"1944.2"	"1641.4"	"7482.4"	"6725.1"	"3961.5"	"4504.8"	"6132.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BUQ8"	"Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3"	"20"	"17"	"37"	"16"	"820"	"95.5"	"9.55"	"6984.24"	"50.92"	"17"	"14"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"other molecular function"	"Pf00270, Pf00271"	"9416"	"ENSG00000174243"	"DDX23"	"B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8"	""	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"2"	"1"	"1324.5"	"817.6"	"1141.9"	"1380.5"	"1813.0"	"1483.2"	"4990.8"	"4514.8"	"3028.2"	"4224.9"	"5523.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08621"	"U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2"	"30"	"12"	"30"	"12"	"437"	"51.5"	"9.94"	"5424.73"	"50.55"	"11"	"11"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076, Pf12220"	"6625"	"ENSG00000104852"	"SNRNP70"	"B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"1118.7"	"741.4"	"1032.9"	"1149.3"	"1415.1"	"1239.0"	"4220.6"	"3944.2"	"2521.3"	"3283.0"	"4507.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13797"	"Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4"	"27"	"14"	"29"	"14"	"630"	"70.8"	"5.60"	"6170.88"	"49.76"	"14"	"13"	"cell organization and biogenesis;developmental processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf13499"	"5358"	"ENSG00000102024"	"PLS3"	"A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6"	""	""	"0"	"0"	"649.6"	"429.3"	"814.0"	"900.3"	"1283.4"	"1038.6"	"1678.8"	"1526.6"	"1057.2"	"1425.1"	"2286.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00267"	"Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1"	"17"	"17"	"33"	"17"	"1087"	"120.9"	"5.06"	"6372.27"	"49.56"	"16"	"14"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00467, Pf03439, Pf11942"	"6829"	"ENSG00000196235"	"SUPT5H"	"hsa:6829; O00267; O43279; Q59G52; Q99639"	"Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing"	"Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE"	"20"	"0"	"1007.4"	"739.8"	"1015.2"	"1465.1"	"1754.8"	"1579.4"	"3230.7"	"3021.6"	"1882.5"	"2219.6"	"2921.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75937"	"DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2"	"44"	"12"	"23"	"12"	"253"	"29.8"	"9.06"	"3412.66"	"49.48"	"8"	"12"	""	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00226"	"22826"	"ENSG00000126698; ENSG00000285317"	"DNAJC8"	"B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"437.4"	"261.8"	"392.8"	"520.4"	"767.0"	"689.4"	"4056.5"	"4062.7"	"2584.9"	"3848.8"	"7983.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43719"	"HIV Tat-specific factor 1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1"	"20"	"13"	"30"	"13"	"755"	"85.8"	"4.40"	"6188.33"	"49.41"	"13"	"12"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	""	"Pf00076"	"27336"	"ENSG00000102241"	"HTATSF1"	"D3DWG9; hsa:27336; O43719; Q59G06; Q99730"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"800.3"	"454.0"	"718.9"	"949.1"	"1110.6"	"1019.4"	"4163.0"	"3988.0"	"2451.3"	"3136.9"	"4026.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14980"	"Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2"	"9"	"16"	"27"	"16"	"2115"	"238.1"	"5.78"	"5600.19"	"49.22"	"13"	"12"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	""	"4926"	"ENSG00000137497"	"NUMA1"	"H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9"	"Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome"	"Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase"	"5"	"0"	"495.4"	"333.9"	"457.4"	"673.4"	"805.5"	"700.1"	"1814.0"	"1711.8"	"1028.4"	"1423.9"	"1771.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50995"	"Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1"	"30"	"14"	"30"	"14"	"505"	"54.4"	"7.65"	"5174.03"	"49.21"	"14"	"14"	"cell cycle OR cell proliferation;transport;other biological processes"	"cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00191"	"311"	"ENSG00000122359"	"ANXA11"	"B4DVE7; hsa:311; P50995"	""	""	"0"	"0"	"669.5"	"431.4"	"611.2"	"1092.7"	"1281.9"	"1083.0"	"2864.5"	"2712.9"	"1751.6"	"2187.1"	"3243.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P27816"	"Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3"	"19"	"18"	"31"	"18"	"1152"	"120.9"	"5.43"	"5882.32"	"48.71"	"16"	"15"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00418"	"4134"	"ENSG00000047849"	"MAP4"	"hsa:4134; P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9"	"Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome"	""	"2"	"0"	"564.3"	"348.6"	"559.2"	"697.2"	"850.5"	"732.4"	"2910.6"	"2708.7"	"1775.4"	"2262.0"	"2941.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94832"	"Unconventional myosin-Id OS=Homo sapiens OX=9606 GN=MYO1D PE=1 SV=2"	"14"	"13"	"31"	"13"	"1006"	"116.1"	"9.39"	"5671.40"	"48.66"	"12"	"12"	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00063, Pf00612, Pf06017"	"4642"	"ENSG00000176658"	"MYO1D"	"A6H8V3; hsa:4642; O94832; Q8NHP9"	""	""	"0"	"0"	"253.6"	"189.4"	"263.2"	"353.6"	"462.6"	"408.7"	"1241.6"	"1445.8"	"1262.9"	"2651.5"	"3719.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78406"	"mRNA export factor OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1"	"38"	"11"	"26"	"11"	"368"	"40.9"	"7.83"	"5818.04"	"48.58"	"11"	"10"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00400"	"8480"	"ENSG00000101146"	"RAE1"	"A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6"	"IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response"	"snRNP Assembly; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Transcriptional regulation by small RNAs; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus"	"30"	"0"	"1433.9"	"870.9"	"1405.8"	"1893.4"	"2145.4"	"2002.6"	"4394.3"	"4683.6"	"2955.6"	"3795.4"	"5598.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60842"	"Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1"	"24"	"11"	"32"	"4"	"406"	"46.1"	"5.48"	"7492.74"	"48.58"	"10"	"9"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"1973"	"ENSG00000161960"	"EIF4A1"	"B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516"	"Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism"	"11"	"5"	"1081.8"	"817.9"	"1084.9"	"1508.3"	"1893.5"	"1713.9"	"2930.8"	"2910.9"	"2025.9"	"2301.0"	"3296.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P40939"	"Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2"	"23"	"14"	"28"	"14"	"763"	"82.9"	"9.04"	"4514.81"	"48.49"	"11"	"14"	"other metabolic processes;other biological processes"	"other membranes;mitochondrion"	"other molecular function"	"Pf00378, Pf00725, Pf02737"	"3030"	"ENSG00000084754"	"HADHA"	"B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5"	"Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA"	"13"	"0"	"443.3"	"311.3"	"479.2"	"582.0"	"750.8"	"640.5"	"1520.4"	"1444.9"	"923.0"	"1310.0"	"1549.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15717"	"ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2"	"33"	"9"	"27"	"9"	"326"	"36.1"	"9.17"	"5537.60"	"48.40"	"9"	"8"	"cell organization and biogenesis;transport;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"1994"	"ENSG00000066044"	"ELAVL1"	"B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1"	"AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome"	"HuR (ELAVL1) binds and stabilizes mRNA"	"10"	"0"	"825.9"	"688.9"	"749.7"	"997.6"	"1277.8"	"1102.2"	"2342.2"	"2342.1"	"1302.4"	"1912.8"	"2473.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13247"	"Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2"	"29"	"10"	"30"	"6"	"344"	"39.6"	"11.43"	"4187.13"	"48.38"	"8"	"9"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076"	"6431"	"ENSG00000124193"	"SRSF6"	"B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"7"	"6"	"1359.7"	"874.2"	"1155.7"	"1414.6"	"1799.0"	"1459.4"	"5392.7"	"4912.3"	"3610.2"	"7522.4"	"9051.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N7H5"	"RNA polymerase II-associated factor 1 homolog OS=Homo sapiens OX=9606 GN=PAF1 PE=1 SV=2"	"30"	"14"	"27"	"14"	"531"	"59.9"	"4.63"	"5122.50"	"48.07"	"13"	"12"	"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"other membranes;nucleus;other cell component"	"other molecular function"	"Pf03985"	"54623"	"ENSG00000006712"	"PAF1"	"hsa:54623; M0QX35; O75239; Q8N7H5; Q9H166; Q9NUU9"	"Endoderm differentiation"	"E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events"	"5"	"0"	"639.7"	"367.1"	"622.7"	"798.7"	"923.6"	"800.9"	"3534.7"	"3475.3"	"2140.0"	"2721.5"	"3462.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13647"	"Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3"	"22"	"16"	"43"	"7"	"590"	"62.3"	"7.74"	"7256.63"	"47.27"	"15"	"13"	"cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;other cell component"	"bone, tooth or skin structural activity;cytoskeletal activity;other molecular function"	"Pf00038, Pf16208"	"3852"	"ENSG00000186081"	"KRT5"	"hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91"	""	"Formation of the cornified envelope; Type I hemidesmosome assembly"	"3"	"0"	"327.4"	"165.8"	"146.8"	"123.0"	"634.7"	"296.3"	"388.1"	"2245.8"	"203.2"	"244.1"	"327.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5X1"	"Sorting nexin-9 OS=Homo sapiens OX=9606 GN=SNX9 PE=1 SV=1"	"20"	"11"	"25"	"11"	"595"	"66.6"	"5.58"	"4566.47"	"47.23"	"9"	"11"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component"	"other molecular function"	"Pf00018, Pf00787, Pf10456"	"51429"	"ENSG00000130340"	"SNX9"	"hsa:51429; Q9BSI7; Q9BVM1; Q9UJH6; Q9UP20; Q9Y5X1"	""	"Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis"	"2"	"0"	"224.1"	"140.2"	"235.3"	"303.2"	"391.4"	"336.2"	"1570.6"	"3247.7"	"3418.2"	"4845.9"	"5791.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55209"	"Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1"	"31"	"9"	"26"	"8"	"391"	"45.3"	"4.46"	"4813.91"	"47.14"	"8"	"8"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00956"	"4673"	"ENSG00000187109"	"NAP1L1"	"B3KNT8; B3KV44; hsa:4673; P55209"	"VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies"	""	"2"	"1"	"322.7"	"157.1"	"337.8"	"462.2"	"591.9"	"478.5"	"1868.4"	"1879.2"	"865.7"	"1201.1"	"1827.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10809"	"60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2"	"27"	"16"	"35"	"16"	"573"	"61.0"	"5.87"	"6108.45"	"46.98"	"16"	"14"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00118"	"3329"	"ENSG00000144381"	"HSPD1"	"B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6"	"Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"	"5"	"0"	"1751.7"	"1091.0"	"1479.1"	"2452.0"	"2892.5"	"2455.0"	"4419.1"	"3924.1"	"2266.3"	"3397.9"	"4205.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13523"	"Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRPF4B PE=1 SV=3"	"13"	"13"	"30"	"12"	"1007"	"116.9"	"10.26"	"6227.29"	"46.80"	"13"	"10"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"8899"	"ENSG00000112739"	"PRPF4B"	"A8K5C9; hsa:8899; Q13523; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"1"	"434.3"	"247.4"	"334.5"	"454.9"	"655.1"	"542.6"	"2892.3"	"2540.6"	"1830.5"	"3046.4"	"4662.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2L1"	"Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2"	"17"	"12"	"22"	"12"	"958"	"108.9"	"7.14"	"3838.00"	"46.74"	"9"	"11"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00773, Pf13638, Pf17215, Pf17216, Pf17849"	"22894"	"ENSG00000083520"	"DIS3"	"A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"6"	"0"	"612.2"	"389.9"	"677.1"	"852.1"	"1035.1"	"917.7"	"2132.8"	"2007.1"	"1251.9"	"1578.6"	"2284.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99459"	"Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2"	"19"	"13"	"25"	"13"	"802"	"92.2"	"8.18"	"5324.46"	"46.65"	"12"	"11"	"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf11831, Pf13921"	"988"	"ENSG00000096401"	"CDC5L"	"hsa:988; Q76N46; Q99459; Q99974"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"689.1"	"375.9"	"607.3"	"861.0"	"1103.2"	"953.3"	"3198.5"	"3092.8"	"1773.9"	"2741.5"	"4275.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62805"	"Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2"	"52"	"7"	"26"	"7"	"103"	"11.4"	"11.36"	"4256.17"	"45.99"	"6"	"7"	"cell organization and biogenesis;other biological processes"	"non-structural extracellular;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf15511"	"121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370"	"ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705"	"H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9"	"A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7"	"Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling"	"Meiotic synapsis; Estrogen-dependent gene expression; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); RNA Polymerase I Promoter Opening; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; SUMOylation of chromatin organization proteins; HCMV Late Events; Amyloid fiber formation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Pre-NOTCH Transcription and Translation; RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); Transcriptional regulation of granulopoiesis"	"50"	"0"	"426.5"	"283.6"	"343.9"	"454.1"	"620.6"	"525.7"	"2165.8"	"2156.4"	"1416.5"	"1779.7"	"2490.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q08170"	"Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2"	"21"	"9"	"26"	"5"	"494"	"56.6"	"11.52"	"3714.90"	"45.93"	"8"	"9"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076"	"6429"	"ENSG00000116350"	"SRSF4"	"hsa:6429; Q08170; Q5VXP1; Q9BUA4; Q9UEB5"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"6"	"0"	"261.0"	"159.7"	"213.1"	"270.4"	"363.6"	"328.3"	"1286.2"	"1176.7"	"748.2"	"1431.2"	"1851.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01105"	"Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3"	"22"	"8"	"25"	"8"	"290"	"33.5"	"4.32"	"4580.54"	"45.86"	"7"	"7"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00956"	"6418"	"ENSG00000119335"	"SET"	"A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5"	"Histone modifications; VEGFA-VEGFR2 signaling"	"Condensation of Prophase Chromosomes; HuR (ELAVL1) binds and stabilizes mRNA"	"4"	"0"	"607.7"	"436.5"	"625.1"	"800.8"	"930.0"	"865.8"	"4236.8"	"4357.4"	"2972.0"	"3358.6"	"4197.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12905"	"Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2"	"22"	"8"	"21"	"8"	"390"	"43.0"	"5.26"	"4126.00"	"45.57"	"7"	"7"	"other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf07528"	"3608"	"ENSG00000143621"	"ILF2"	"A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0"	"B cell receptor signaling pathway"	"Neutrophil degranulation"	"2"	"0"	"714.7"	"416.8"	"596.4"	"755.8"	"960.6"	"860.4"	"2478.5"	"1994.7"	"1481.7"	"1810.9"	"2437.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11908"	"Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2"	"34"	"11"	"32"	"3"	"318"	"34.7"	"6.61"	"5617.58"	"45.54"	"10"	"9"	"other metabolic processes;other biological processes"	"cytosol;other cell component"	"kinase activity;other molecular function"	"Pf13793, Pf14572"	"5634"	"ENSG00000101911"	"PRPS2"	"hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7"	""	"5-Phosphoribose 1-diphosphate biosynthesis"	"1"	"0"	"203.9"	"126.9"	"192.4"	"359.4"	"399.9"	"338.3"	"736.9"	"761.3"	"432.8"	"528.8"	"607.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22102"	"Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1"	"17"	"12"	"20"	"12"	"1010"	"107.7"	"6.70"	"2929.74"	"45.05"	"7"	"11"	"other metabolic processes;developmental processes;other biological processes"	"cytosol"	"other molecular function"	"Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844"	"2618"	"ENSG00000159131; ENSG00000262473"	"GART"	"A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77"	"Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer"	"Purine ribonucleoside monophosphate biosynthesis"	"4"	"0"	"136.1"	"87.2"	"138.5"	"182.2"	"217.2"	"195.3"	"485.7"	"661.3"	"832.6"	"2096.4"	"4337.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00148"	"ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2"	"24"	"10"	"30"	"2"	"427"	"49.1"	"5.68"	"5155.93"	"44.79"	"10"	"8"	"RNA metabolism OR transcription;other metabolic processes;transport"	"nucleus;other cell component"	"other molecular function"	"Pf00270, Pf00271"	"10212"	"ENSG00000123136"	"DDX39A"	"B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"3"	"0"	"29.8"	"25.6"	"36.6"	"37.9"	"50.7"	"36.1"	"124.6"	"133.9"	"122.7"	"128.9"	"143.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52272"	"Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3"	"26"	"14"	"27"	"14"	"730"	"77.5"	"8.70"	"4857.00"	"44.65"	"12"	"13"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf11532"	"4670"	"ENSG00000099783"	"HNRNPM"	"hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; FGFR2 alternative splicing"	"4"	"0"	"1089.9"	"754.5"	"957.7"	"1286.6"	"1675.1"	"1451.4"	"3206.1"	"2781.6"	"1514.6"	"2287.9"	"2955.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q05639"	"Elongation factor 1-alpha 2 OS=Homo sapiens OX=9606 GN=EEF1A2 PE=1 SV=1"	"19"	"8"	"28"	"2"	"463"	"50.4"	"9.03"	"4658.50"	"44.62"	"7"	"8"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00009, Pf03143, Pf03144"	"1917"	"ENSG00000101210"	"EEF1A2"	"B5BUF3; E1P5J1; hsa:1917; P54266; Q05639; Q0VGC7"	"Translation factors"	"Eukaryotic Translation Elongation"	"2"	"0"	"121.9"	"76.4"	"112.7"	"173.1"	"201.5"	"189.8"	"550.6"	"519.1"	"393.8"	"500.1"	"729.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61247"	"40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2"	"53"	"15"	"34"	"15"	"264"	"29.9"	"9.73"	"6609.04"	"44.58"	"14"	"12"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01015"	"6189"	"ENSG00000145425"	"RPS3A"	"B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"1691.5"	"1054.9"	"1520.4"	"1770.8"	"2280.3"	"1886.0"	"7294.7"	"6491.3"	"4149.5"	"4990.6"	"6238.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08708"	"40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2"	"57"	"7"	"15"	"7"	"135"	"15.5"	"9.85"	"1507.30"	"44.50"	"4"	"7"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf00833"	"6218"	"ENSG00000182774; ENSG00000278229"	"RPS17"	"B2R4U4; hsa:6218; P08708; P0CW22"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"290.7"	"201.7"	"304.7"	"363.1"	"451.0"	"386.8"	"1457.0"	"1382.8"	"947.6"	"1148.5"	"1267.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43852"	"Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2"	"50"	"13"	"23"	"13"	"315"	"37.1"	"4.64"	"3758.91"	"44.39"	"11"	"12"	""	"non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf13833"	"813"	"ENSG00000128595"	"CALU"	"B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43"	"NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling"	"Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation"	"5"	"0"	"591.6"	"383.2"	"551.9"	"927.8"	"1059.8"	"895.5"	"2946.4"	"2862.5"	"1660.8"	"2145.5"	"2443.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q10570"	"Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2"	"14"	"16"	"28"	"16"	"1443"	"160.8"	"6.40"	"4268.74"	"43.80"	"13"	"15"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf03178, Pf10433"	"29894"	"ENSG00000071894; ENSG00000285049"	"CPSF1"	"hsa:29894; Q10570; Q96AF0"	"mRNA processing"	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; Processing of Intronless Pre-mRNAs"	"7"	"0"	"478.3"	"387.3"	"544.3"	"791.6"	"934.5"	"815.3"	"1781.6"	"1774.1"	"1100.9"	"1334.0"	"1585.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q04837"	"Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1"	"48"	"8"	"21"	"8"	"148"	"17.2"	"9.60"	"3621.56"	"43.76"	"6"	"8"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes"	"mitochondrion"	"nucleic acid binding activity;other molecular function"	"Pf00436"	"6742"	"ENSG00000106028; ENSG00000262771"	"SSBP1"	"hsa:6742; Q04837"	""	"Transcriptional activation of mitochondrial biogenesis"	"1"	"0"	"479.2"	"355.5"	"484.9"	"635.7"	"792.8"	"695.7"	"1529.9"	"1506.9"	"1041.7"	"1268.8"	"1811.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12268"	"Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2"	"26"	"11"	"28"	"11"	"514"	"55.8"	"6.90"	"6559.82"	"43.67"	"10"	"10"	"cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00478, Pf00571"	"3615"	"ENSG00000178035"	"IMPDH2"	"hsa:3615; P12268; Q6LEF3"	"Rett syndrome causing genes"	"Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME"	"5"	"0"	"398.8"	"285.1"	"356.7"	"611.1"	"676.0"	"578.0"	"1982.7"	"1837.9"	"997.6"	"1437.9"	"1888.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WXF1"	"Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1"	"20"	"9"	"20"	"9"	"523"	"58.7"	"6.67"	"3523.74"	"43.59"	"8"	"9"	"stress response;other biological processes"	"nucleus;other cell component"	""	"Pf00076, Pf08075"	"55269"	"ENSG00000121390"	"PSPC1"	"hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36"	""	""	"0"	"0"	"367.6"	"250.3"	"357.5"	"536.3"	"672.7"	"526.0"	"2474.6"	"2199.5"	"1482.4"	"1800.4"	"2420.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H0D6"	"5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1"	"14"	"11"	"24"	"11"	"950"	"108.5"	"7.47"	"4682.62"	"43.53"	"8"	"10"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03159, Pf17846"	"22803"	"ENSG00000088930"	"XRN2"	"hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53"	"mRNA processing"	"Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis"	"3"	"0"	"319.5"	"195.2"	"355.9"	"554.8"	"638.4"	"575.6"	"1632.5"	"1572.0"	"758.2"	"1013.8"	"1503.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P36578"	"60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5"	"34"	"14"	"31"	"13"	"427"	"47.7"	"11.06"	"5735.05"	"43.49"	"13"	"10"	"protein metabolism;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf00573, Pf14374"	"6124"	"ENSG00000174444"	"RPL4"	"A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"1"	"829.7"	"568.6"	"748.4"	"901.7"	"1125.6"	"1009.7"	"4095.6"	"3657.6"	"2637.7"	"3347.8"	"4146.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L014"	"Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2"	"18"	"17"	"32"	"17"	"1031"	"117.3"	"9.29"	"6454.88"	"43.40"	"17"	"13"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"other membranes;nucleus"	"other molecular function"	"Pf00270, Pf00271"	"9879"	"ENSG00000145833"	"DDX46"	"hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"792.0"	"516.2"	"785.0"	"1021.0"	"1255.2"	"1085.4"	"3077.9"	"2822.6"	"1826.9"	"2385.8"	"3339.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15365"	"Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2"	"37"	"11"	"24"	"5"	"356"	"37.5"	"7.09"	"4858.36"	"43.33"	"9"	"11"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013"	"5093"	"ENSG00000169564"	"PCBP1"	"hsa:5093; Q13157; Q14975; Q15365"	"Ferroptosis"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"3"	"8"	"724.5"	"555.5"	"809.4"	"1362.1"	"1571.1"	"1285.6"	"3673.3"	"3414.7"	"2125.5"	"2207.1"	"2135.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99832"	"T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2"	"31"	"14"	"27"	"14"	"543"	"59.3"	"7.65"	"3980.93"	"42.98"	"10"	"14"	"protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00118"	"10574"	"ENSG00000135624"	"CCT7"	"A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832"	"VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome"	"Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC"	"9"	"0"	"816.3"	"464.6"	"788.4"	"1112.9"	"1369.9"	"1168.4"	"2443.4"	"2203.2"	"985.7"	"1472.4"	"2200.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43290"	"U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1"	"20"	"12"	"25"	"12"	"800"	"90.2"	"6.13"	"4999.66"	"42.35"	"12"	"11"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	""	"Pf03343, Pf19252"	"9092"	"ENSG00000175467"	"SART1"	"A6NDN1; hsa:9092; O43290; Q53GB5"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"440.5"	"274.0"	"406.1"	"526.7"	"721.5"	"557.2"	"1998.6"	"1754.7"	"1169.9"	"1482.5"	"1992.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62269"	"40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3"	"45"	"11"	"30"	"11"	"152"	"17.7"	"10.99"	"6041.39"	"42.28"	"11"	"8"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00416"	"6222"	"ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650"	"RPS18"	"hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"1185.6"	"908.0"	"1208.2"	"1396.1"	"1722.8"	"1536.2"	"5153.9"	"4505.9"	"3007.1"	"3558.2"	"4770.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31942"	"Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2"	"34"	"8"	"21"	"7"	"346"	"36.9"	"6.87"	"3516.08"	"42.21"	"6"	"8"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf00076"	"3189"	"ENSG00000096746"	"HNRNPH3"	"A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5"	""	""	"0"	"0"	"487.7"	"314.3"	"457.4"	"673.0"	"743.2"	"673.7"	"1793.3"	"1453.9"	"951.3"	"1278.9"	"1500.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P48643"	"T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1"	"25"	"14"	"27"	"14"	"541"	"59.6"	"5.66"	"5535.07"	"42.05"	"13"	"11"	"protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00118"	"22948"	"ENSG00000150753"	"CCT5"	"A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643"	"16p11.2 proximal deletion syndrome"	"Prefoldin mediated transfer of substrate  to CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Folding of actin by CCT/TriC"	"7"	"0"	"1030.4"	"748.0"	"1121.0"	"1490.9"	"1807.1"	"1573.6"	"2765.8"	"2725.0"	"1752.4"	"2312.8"	"2897.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NYF8"	"Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2"	"14"	"11"	"23"	"11"	"920"	"106.1"	"9.98"	"4834.06"	"41.84"	"10"	"11"	"stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf15440"	"9774"	"ENSG00000029363"	"BCLAF1"	"A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8"	"Interactome of polycomb repressive complex 2 (PRC2)"	""	"1"	"0"	"1530.2"	"858.9"	"1250.4"	"1488.8"	"2032.4"	"1831.4"	"5311.6"	"4086.4"	"2300.8"	"3832.9"	"4579.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52292"	"Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1"	"25"	"10"	"19"	"10"	"529"	"57.8"	"5.40"	"3435.22"	"41.60"	"8"	"9"	"DNA metabolism;other metabolic processes;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00514, Pf01749, Pf16186"	"3838"	"ENSG00000182481"	"KPNA2"	"B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5"	""	"ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"	"8"	"0"	"523.2"	"382.8"	"576.7"	"901.4"	"1023.8"	"874.0"	"2421.1"	"2552.0"	"1454.7"	"1754.7"	"2030.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30153"	"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4"	"23"	"13"	"28"	"13"	"589"	"65.3"	"5.11"	"4973.55"	"41.59"	"11"	"11"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf02985"	"5518"	"ENSG00000105568"	"PPP2R1A"	"hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3"	"Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome"	"Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Regulation of TP53 Degradation; Cyclin D associated events in G1; Spry regulation of FGF signaling; Negative regulation of MAPK pathway; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated"	"49"	"0"	"954.6"	"720.6"	"1088.0"	"1776.8"	"2125.9"	"1810.2"	"3609.1"	"3736.8"	"2120.6"	"2528.3"	"3441.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P42704"	"Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3"	"12"	"13"	"25"	"13"	"1394"	"157.8"	"6.13"	"4278.28"	"41.49"	"11"	"13"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"other membranes;cytoskeleton;mitochondrion;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf01535"	"10128"	"ENSG00000138095"	"LRPPRC"	"A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84"	"Ciliary landscape"	"Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1"	"4"	"0"	"360.4"	"284.5"	"394.3"	"663.1"	"778.3"	"648.6"	"1356.9"	"1359.3"	"855.0"	"1030.1"	"1103.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15283"	"Ras GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RASA2 PE=1 SV=3"	"17"	"14"	"26"	"14"	"850"	"96.6"	"7.20"	"4518.43"	"41.47"	"11"	"13"	"signal transduction;other biological processes"	"cytosol;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00168, Pf00169, Pf00616, Pf00779"	"5922"	"ENSG00000155903"	"RASA2"	"A8K7K1; G3V0F9; hsa:5922; O00695; Q15283; Q15284; Q92594; Q99577; Q9UEQ2"	"MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation"	"Regulation of RAS by GAPs"	"5"	"0"	"199.9"	"136.8"	"223.6"	"323.1"	"378.2"	"421.4"	"1823.7"	"3586.8"	"2706.5"	"3303.2"	"3674.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P42285"	"Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3"	"16"	"14"	"27"	"14"	"1042"	"117.7"	"6.52"	"4231.39"	"41.41"	"12"	"13"	"RNA metabolism OR transcription;other metabolic processes;stress response"	"nucleus"	"other molecular function"	"Pf00270, Pf00271, Pf08148, Pf13234"	"23517"	"ENSG00000039123"	"MTREX"	"hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2"	""	"mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol"	"2"	"0"	"482.8"	"290.3"	"435.7"	"620.7"	"786.0"	"680.3"	"2519.0"	"2576.3"	"1574.0"	"2353.3"	"3555.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49368"	"T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4"	"31"	"16"	"29"	"16"	"545"	"60.5"	"6.49"	"5989.18"	"41.33"	"15"	"12"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00118"	"7203"	"ENSG00000163468"	"CCT3"	"A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64"	"16p11.2 proximal deletion syndrome"	"Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC"	"7"	"0"	"942.0"	"704.5"	"1005.9"	"1362.1"	"1594.7"	"1456.6"	"2297.8"	"2301.3"	"1360.2"	"1837.5"	"2493.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61221"	"ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1"	"27"	"11"	"20"	"11"	"599"	"67.3"	"8.34"	"4056.60"	"41.32"	"9"	"11"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;mitochondrion;translational apparatus;other cell component"	"enzyme regulator activity;translation activity;other molecular function"	"Pf00005, Pf00037, Pf04068"	"6059"	"ENSG00000164163"	"ABCE1"	"hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66"	""	"OAS antiviral response; Interferon alpha/beta signaling"	"2"	"0"	"340.1"	"223.1"	"307.2"	"375.7"	"514.7"	"454.4"	"2135.5"	"2226.6"	"1581.4"	"2223.5"	"3333.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UHX1"	"Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1"	"19"	"10"	"23"	"10"	"559"	"59.8"	"5.29"	"3540.20"	"41.27"	"8"	"9"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"22827"	"ENSG00000179950; ENSG00000274081"	"PUF60"	"A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"875.0"	"638.4"	"900.3"	"1098.6"	"1284.4"	"1029.2"	"2145.4"	"2046.0"	"1266.5"	"1644.1"	"2305.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P27695"	"DNA-(apurinic or apyrimidinic site) lyase OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2"	"38"	"9"	"22"	"9"	"318"	"35.5"	"8.12"	"4680.18"	"41.05"	"9"	"8"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03372"	"328"	"ENSG00000100823"	"APEX1"	"hsa:328; P27695; Q969L5; Q99775"	"Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network"	"Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"	"10"	"0"	"160.5"	"100.4"	"163.1"	"200.1"	"297.0"	"237.7"	"2400.4"	"2316.8"	"1679.6"	"2024.8"	"3218.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55884"	"Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3"	"20"	"11"	"18"	"11"	"814"	"92.4"	"5.00"	"3277.59"	"40.94"	"8"	"10"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf08662"	"8662"	"ENSG00000106263"	"EIF3B"	"A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition"	"8"	"0"	"410.0"	"295.3"	"399.0"	"447.6"	"562.5"	"522.5"	"1195.3"	"1121.4"	"695.5"	"863.9"	"1275.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09012"	"U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3"	"35"	"8"	"27"	"6"	"282"	"31.3"	"9.83"	"4318.25"	"40.89"	"6"	"7"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"6626"	"ENSG00000077312"	"SNRPA"	"hsa:6626; P09012"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"3"	"1813.4"	"1146.3"	"1627.9"	"1799.0"	"2155.2"	"1946.1"	"6123.8"	"5778.1"	"3547.6"	"4580.8"	"7402.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43776"	"Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1"	"24"	"11"	"24"	"11"	"548"	"62.9"	"6.25"	"4744.42"	"40.85"	"8"	"10"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf00152, Pf01336"	"4677"	"ENSG00000134440"	"NARS1"	"B4DG16; hsa:4677; O43776; Q53GU6"	"Photodynamic therapy-induced unfolded protein response"	"Cytosolic tRNA aminoacylation"	"2"	"0"	"205.3"	"135.2"	"237.0"	"306.2"	"391.2"	"351.7"	"966.9"	"1092.0"	"1245.9"	"2784.5"	"6429.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15366"	"Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1"	"27"	"9"	"25"	"2"	"365"	"38.6"	"6.79"	"5369.25"	"40.82"	"8"	"9"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013"	"5094"	"ENSG00000197111"	"PCBP2"	"A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5"	"mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses"	"7"	"1"	"239.2"	"190.7"	"284.3"	"492.2"	"511.2"	"455.2"	"1395.0"	"1344.6"	"887.0"	"918.0"	"891.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99986"	"Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1"	"22"	"11"	"26"	"11"	"396"	"45.4"	"8.91"	"4858.80"	"40.43"	"11"	"10"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;ER/Golgi;nucleus"	"kinase activity;other molecular function"	"Pf00069"	"7443"	"ENSG00000100749"	"VRK1"	"hsa:7443; Q3SYL2; Q99986"	""	"Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation"	"2"	"0"	"268.5"	"147.6"	"238.3"	"305.8"	"422.4"	"345.8"	"4483.9"	"4436.7"	"2705.4"	"4089.6"	"8304.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P01116"	"GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1"	"42"	"7"	"19"	"7"	"189"	"21.6"	"6.77"	"3300.95"	"40.43"	"5"	"7"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00071"	"3845"	"ENSG00000133703"	"KRAS"	"A8K8Z5; B0LPF9; hsa:3845; P01116; P01118; Q96D10"	"IL-5 signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; MAPK pathway in congenital thyroid cancer; Regulation of actin cytoskeleton; Alzheimer's disease; Autophagy in pancreatic ductal adenocarcinoma; JAK-STAT signaling in the regulation of Beta-cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling"	"Signaling by CSF3 (G-CSF); Signaling by CSF1 (M-CSF) in myeloid cells; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants; RUNX3 regulates p14-ARF"	"57"	"0"	"195.4"	"167.9"	"219.8"	"271.5"	"323.2"	"299.6"	"681.3"	"671.3"	"736.7"	"875.6"	"1086.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11177"	"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3"	"30"	"9"	"24"	"9"	"359"	"39.2"	"6.65"	"5246.59"	"40.16"	"9"	"9"	"other metabolic processes"	"mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf02779, Pf02780"	"5162"	"ENSG00000168291"	"PDHB"	"B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3"	"Metabolic reprogramming in colon cancer; Orexin receptor pathway"	"Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid"	"6"	"0"	"609.8"	"379.3"	"632.6"	"763.6"	"916.3"	"821.8"	"1827.9"	"1873.7"	"1142.2"	"1395.6"	"1743.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22234"	"Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3"	"26"	"9"	"22"	"9"	"425"	"47.0"	"7.23"	"3912.20"	"40.11"	"8"	"7"	"other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf00731, Pf01259"	"10606"	"ENSG00000128050"	"PAICS"	"E9PDH9; hsa:10606; P22234; Q68CQ5"	"Metabolic reprogramming in colon cancer"	"Purine ribonucleoside monophosphate biosynthesis"	"2"	"0"	"724.7"	"464.2"	"720.3"	"961.7"	"1115.2"	"1035.8"	"1685.1"	"1597.5"	"1080.3"	"1399.1"	"2317.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NBS9"	"Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2"	"29"	"12"	"24"	"11"	"432"	"47.6"	"5.97"	"3487.10"	"40.03"	"9"	"11"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;ER/Golgi;other cytoplasmic organelle"	"other molecular function"	"Pf00085"	"81567"	"ENSG00000239264"	"TXNDC5"	"B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9"	"VEGFA-VEGFR2 signaling"	"Neutrophil degranulation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis"	"4"	"1"	"1371.4"	"1000.4"	"1577.8"	"2170.3"	"2396.9"	"2331.6"	"3649.3"	"3936.8"	"2269.6"	"2326.0"	"2572.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q07021"	"Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1"	"30"	"5"	"20"	"5"	"282"	"31.3"	"4.84"	"3585.26"	"39.79"	"4"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function"	"Pf02330"	"708"	"ENSG00000108561"	"C1QBP"	"hsa:708; Q07021; Q2HXR8; Q9NNY8"	"Complement system; Mesodermal commitment pathway; Ebola virus infection in host"	"RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function"	"8"	"0"	"348.3"	"296.3"	"360.6"	"445.2"	"550.6"	"534.2"	"1494.7"	"1422.1"	"1132.7"	"1221.9"	"1585.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62136"	"Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1"	"35"	"9"	"21"	"3"	"330"	"37.5"	"6.33"	"4196.11"	"39.65"	"8"	"9"	"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00149, Pf16891"	"5499"	"ENSG00000172531"	"PPP1CA"	"A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161"	"Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling"	"Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; DARPP-32 events"	"13"	"5"	"411.1"	"281.8"	"384.0"	"500.8"	"645.0"	"620.6"	"1979.3"	"2102.1"	"1415.8"	"1700.0"	"2042.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43684"	"Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1"	"29"	"10"	"25"	"10"	"328"	"37.1"	"6.84"	"5119.45"	"39.59"	"10"	"8"	"cell cycle OR cell proliferation;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00400"	"9184"	"ENSG00000154473"	"BUB3"	"A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685"	"Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition"	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A"	"12"	"0"	"1003.9"	"736.0"	"1051.0"	"1289.8"	"1545.1"	"1462.8"	"4246.9"	"4206.3"	"2930.3"	"3491.2"	"4981.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95831"	"Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1"	"18"	"9"	"22"	"9"	"613"	"66.9"	"8.95"	"4224.49"	"39.51"	"9"	"9"	"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00070, Pf14721"	"9131"	"ENSG00000156709"	"AIFM1"	"A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; hsa:9131; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4"	"Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70"	""	"3"	"0"	"492.3"	"390.6"	"523.4"	"785.2"	"950.4"	"884.3"	"1737.5"	"1754.2"	"1218.6"	"1527.0"	"2211.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18124"	"60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1"	"30"	"7"	"22"	"7"	"248"	"29.2"	"10.65"	"4167.87"	"39.30"	"7"	"7"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00327, Pf08079"	"6129"	"ENSG00000147604"	"RPL7"	"A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"227.6"	"152.6"	"219.6"	"266.6"	"332.1"	"280.1"	"1137.2"	"986.4"	"643.5"	"922.9"	"1106.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96PK6"	"RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2"	"21"	"13"	"23"	"13"	"669"	"69.4"	"9.67"	"3861.81"	"39.13"	"11"	"12"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00076"	"100526737; 10432"	"ENSG00000239306"	"RBM14"	"B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6"	"Ciliary landscape"	"RUNX2 regulates bone development"	"2"	"0"	"560.0"	"421.8"	"503.2"	"596.4"	"770.6"	"677.9"	"3353.0"	"3125.8"	"2499.6"	"2693.7"	"2934.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q00688"	"Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1"	"42"	"11"	"26"	"11"	"224"	"25.2"	"9.28"	"4184.96"	"39.12"	"10"	"9"	""	"nucleus"	"other molecular function"	"Pf00254, Pf18410"	"2287"	"ENSG00000100442"	"FKBP3"	"B2R4Q9; hsa:2287; Q00688; Q14317"	""	""	"0"	"0"	"230.4"	"128.8"	"247.6"	"290.9"	"383.6"	"351.2"	"4319.9"	"4379.9"	"3555.1"	"5310.7"	"10733.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46013"	"Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2"	"6"	"13"	"25"	"13"	"3256"	"358.5"	"9.45"	"4306.03"	"39.09"	"13"	"12"	"cell cycle OR cell proliferation;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00498, Pf08065, Pf15276"	"4288"	"ENSG00000148773"	"MKI67"	"hsa:4288; P46013; Q5VWH2"	"Primary focal segmental glomerulosclerosis (FSGS)"	""	"1"	"0"	"272.0"	"168.4"	"239.3"	"322.2"	"414.8"	"347.9"	"1236.6"	"1175.3"	"693.2"	"878.2"	"1107.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P39023"	"60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2"	"28"	"11"	"19"	"11"	"403"	"46.1"	"10.18"	"2401.66"	"38.27"	"7"	"10"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00297"	"6122"	"ENSG00000100316"	"RPL3"	"B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"907.1"	"501.6"	"804.2"	"973.5"	"1242.0"	"1021.0"	"5064.4"	"4462.7"	"2453.4"	"3543.3"	"4273.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62304"	"Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1"	"70"	"5"	"18"	"5"	"92"	"10.8"	"9.44"	"2893.56"	"38.24"	"3"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf01423"	"6635"	"ENSG00000182004"	"SNRPE"	"B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2"	"mRNA processing"	"mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"	"8"	"0"	"204.0"	"178.3"	"236.2"	"227.2"	"281.2"	"265.9"	"662.8"	"659.4"	"434.5"	"553.2"	"717.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P68400"	"Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1"	"28"	"8"	"20"	"7"	"391"	"45.1"	"7.74"	"3301.35"	"37.89"	"6"	"8"	"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"1457"	"ENSG00000101266"	"CSNK2A1"	"B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065"	"Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease"	"Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC"	"21"	"1"	"158.9"	"129.0"	"178.0"	"238.3"	"282.8"	"254.0"	"1516.6"	"1649.5"	"1150.4"	"1753.5"	"2509.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62081"	"40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1"	"41"	"9"	"17"	"9"	"194"	"22.1"	"10.10"	"2314.51"	"37.86"	"5"	"9"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;cytoskeleton;translational apparatus;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf01251"	"6201"	"ENSG00000171863"	"RPS7"	"hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); rRNA modification in the nucleus and cytosol; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"20"	"0"	"968.6"	"600.6"	"890.4"	"1022.6"	"1264.0"	"1117.2"	"4019.7"	"3451.7"	"2228.1"	"2842.5"	"3357.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18754"	"Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1"	"25"	"10"	"23"	"10"	"421"	"44.9"	"7.52"	"4578.65"	"37.76"	"10"	"9"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00415"	"1104"	"ENSG00000180198"	"RCC1"	"hsa:1104; P18754; Q16269; Q6NT97"	"22q11.2 copy number variation syndrome"	"Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation"	"4"	"0"	"558.6"	"335.3"	"569.8"	"755.1"	"927.4"	"847.4"	"3663.0"	"3844.0"	"2108.5"	"2697.4"	"3820.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A6NHR9"	"Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2"	"9"	"13"	"22"	"13"	"2005"	"226.2"	"7.30"	"3720.85"	"37.55"	"10"	"12"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf06470, Pf13589"	"23347"	"ENSG00000101596"	"SMCHD1"	"A6NHR9; hsa:23347; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39"	""	""	"0"	"0"	"225.0"	"143.6"	"222.5"	"249.0"	"338.3"	"274.7"	"1114.3"	"1084.6"	"707.5"	"829.6"	"1016.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75131"	"Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1"	"26"	"10"	"18"	"9"	"537"	"60.1"	"5.85"	"2530.73"	"37.45"	"8"	"9"	"signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;kinase activity;other molecular function"	"Pf00168, Pf07002"	"8895"	"ENSG00000085719"	"CPNE3"	"A8KA47; hsa:8895; O75131; Q8IYA1"	""	"Neutrophil degranulation; Glycerophospholipid biosynthesis"	"2"	"0"	"229.8"	"164.0"	"242.0"	"303.9"	"364.1"	"353.6"	"650.9"	"585.6"	"424.8"	"601.0"	"1049.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22061"	"Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4"	"38"	"9"	"25"	"9"	"227"	"24.6"	"7.21"	"5328.85"	"37.44"	"9"	"8"	"protein metabolism;other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf01135"	"5110"	"ENSG00000120265"	"PCMT1"	"A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03"	"Primary ovarian insufficiency"	"Protein repair"	"2"	"0"	"726.7"	"584.1"	"906.9"	"1814.1"	"2166.2"	"1870.3"	"3085.3"	"3047.9"	"2277.5"	"2506.3"	"3869.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96E39"	"RNA binding motif protein, X-linked-like-1 OS=Homo sapiens OX=9606 GN=RBMXL1 PE=1 SV=1"	"21"	"6"	"26"	"1"	"390"	"42.1"	"9.89"	"4645.68"	"37.42"	"6"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076, Pf08081"	"494115"	"ENSG00000213516"	"RBMXL1"	"hsa:494115; Q96E39"	""	""	"0"	"0"	"75.1"	"55.1"	"71.3"	"90.0"	"112.9"	"98.3"	"243.8"	"195.6"	"125.9"	"179.8"	"272.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62241"	"40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2"	"51"	"10"	"21"	"10"	"208"	"24.2"	"10.32"	"2643.06"	"37.38"	"8"	"10"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01201"	"6202"	"ENSG00000142937"	"RPS8"	"hsa:6202; P09058; P62241; Q6IRL7"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"618.9"	"465.1"	"619.3"	"662.6"	"815.3"	"713.3"	"2445.7"	"2215.3"	"1794.1"	"1917.7"	"2105.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKV3"	"Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2"	"11"	"14"	"24"	"14"	"1341"	"151.8"	"6.43"	"4645.21"	"37.30"	"13"	"11"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02037, Pf16294"	"22985"	"ENSG00000100813"	"ACIN1"	"B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3"	""	"mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins"	"2"	"0"	"628.1"	"377.4"	"493.9"	"632.5"	"901.1"	"768.1"	"2298.4"	"1950.1"	"1568.6"	"3186.1"	"4190.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P39748"	"Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1"	"23"	"7"	"20"	"7"	"380"	"42.6"	"8.62"	"3419.64"	"37.17"	"6"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00752, Pf00867"	"2237"	"ENSG00000168496"	"FEN1"	"hsa:2237; P39748"	"Base excision repair; DNA repair pathways, full network"	"HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand"	"8"	"0"	"222.0"	"117.0"	"203.6"	"251.9"	"327.4"	"282.0"	"3230.0"	"3011.8"	"2024.8"	"2910.1"	"4208.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P38919"	"Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4"	"23"	"12"	"26"	"10"	"411"	"46.8"	"6.73"	"5499.60"	"37.06"	"11"	"10"	"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"9775"	"ENSG00000141543"	"EIF4A3"	"hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18"	"TAR syndrome"	"mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"9"	"2"	"903.0"	"597.8"	"778.9"	"1096.8"	"1436.3"	"1209.3"	"3050.2"	"2726.8"	"1798.6"	"2617.2"	"3512.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08579"	"U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1"	"30"	"6"	"22"	"4"	"225"	"25.5"	"9.72"	"3070.40"	"37.03"	"5"	"6"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"6629"	"ENSG00000125870"	"SNRPB2"	"B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4"	"mRNA processing; Ciliary landscape"	"mRNA Splicing - Major Pathway"	"3"	"0"	"645.4"	"484.6"	"596.1"	"664.8"	"792.0"	"729.0"	"1777.2"	"1661.9"	"1201.7"	"1278.2"	"1775.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TCS8"	"Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2"	"17"	"10"	"20"	"10"	"783"	"85.9"	"7.77"	"4109.84"	"36.75"	"8"	"10"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf01138, Pf03725, Pf03726"	"87178"	"ENSG00000138035"	"PNPT1"	"hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0"	"Pyrimidine metabolism; miRNA degrading enzymes"	""	"2"	"0"	"241.5"	"183.1"	"247.3"	"325.7"	"402.0"	"360.5"	"1153.8"	"1131.4"	"830.8"	"875.9"	"1377.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P15880"	"40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2"	"30"	"9"	"24"	"9"	"293"	"31.3"	"10.24"	"4236.27"	"36.66"	"9"	"9"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00333, Pf03719"	"6187"	"ENSG00000140988"	"RPS2"	"B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; RMTs methylate histone arginines; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Protein methylation; Peptide chain elongation; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"22"	"0"	"965.9"	"620.5"	"854.4"	"1128.9"	"1367.3"	"1213.0"	"4708.0"	"4311.6"	"2937.4"	"3251.6"	"4612.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96AE4"	"Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3"	"20"	"14"	"27"	"9"	"644"	"67.5"	"7.61"	"4191.74"	"36.52"	"13"	"13"	"other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00013, Pf09005"	"8880"	"ENSG00000162613"	"FUBP1"	"hsa:8880; Q12828; Q96AE4"	""	""	"0"	"5"	"768.6"	"482.1"	"698.8"	"1049.2"	"1320.8"	"1142.3"	"3167.4"	"2756.1"	"1715.9"	"2240.2"	"2603.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99584"	"Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1"	"48"	"5"	"19"	"5"	"98"	"11.5"	"6.16"	"2823.05"	"36.49"	"4"	"5"	"transport;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf01023"	"6284"	"ENSG00000189171"	"S100A13"	"hsa:6284; Q52PI9; Q6FGF8; Q99584"	""	""	"0"	"0"	"289.5"	"195.2"	"334.1"	"360.9"	"450.0"	"406.8"	"1331.2"	"1597.9"	"1061.0"	"1805.0"	"5706.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31930"	"Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3"	"28"	"10"	"17"	"10"	"480"	"52.6"	"6.37"	"2815.61"	"36.47"	"7"	"8"	"other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf00675, Pf05193"	"7384"	"ENSG00000010256"	"UQCRC1"	"B2R7R8; hsa:7384; P31930; Q96DD2"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly"	"Respiratory electron transport"	"4"	"0"	"504.3"	"437.4"	"585.8"	"971.0"	"1105.6"	"1004.7"	"1488.2"	"1372.1"	"1051.8"	"1339.9"	"1655.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63241"	"Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2"	"53"	"7"	"22"	"7"	"154"	"16.8"	"5.24"	"3942.40"	"36.41"	"6"	"6"	"protein metabolism;other metabolic processes;signal transduction;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"translation activity;nucleic acid binding activity"	"Pf01287"	"1984"	"ENSG00000132507; ENSG00000288145"	"EIF5A"	"A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2"	"Translation factors; eIF5A regulation in response to inhibition of the nuclear export system"	"Hypusine synthesis from eIF5A-lysine"	"3"	"0"	"951.1"	"626.4"	"887.4"	"1156.7"	"1480.2"	"1398.4"	"3074.0"	"3139.9"	"2293.1"	"3541.4"	"7385.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5BKZ1"	"DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2"	"18"	"9"	"21"	"9"	"582"	"65.6"	"5.15"	"3852.97"	"36.12"	"9"	"8"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04988"	"284695"	"ENSG00000162664"	"ZNF326"	"A8MYX1; B4DLN0; B4E179; hsa:284695; Q5BKZ1; Q5VW93; Q5VW94; Q5VW96; Q5VW97; Q6NSA2; Q7Z638; Q7Z6C2"	""	""	"0"	"0"	"440.1"	"299.5"	"421.6"	"639.0"	"741.7"	"597.0"	"1399.7"	"1198.3"	"651.8"	"1010.0"	"1198.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86V81"	"THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3"	"33"	"5"	"11"	"5"	"257"	"26.9"	"11.15"	"1236.03"	"36.10"	"3"	"5"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf13865"	"10189"	""	"ALYREF"	"hsa:10189; O43672; Q86V81"	""	"mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript"	"7"	"0"	"194.9"	"147.4"	"195.4"	"226.0"	"309.4"	"242.2"	"733.0"	"682.6"	"543.0"	"674.1"	"730.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q93009"	"Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2"	"9"	"8"	"20"	"8"	"1102"	"128.2"	"5.55"	"4257.49"	"35.71"	"8"	"8"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00443, Pf00917, Pf12436, Pf14533"	"7874"	"ENSG00000187555"	"USP7"	"A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009"	"Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates"	"Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TP53 Degradation; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization"	"10"	"0"	"296.2"	"215.9"	"350.1"	"554.8"	"634.7"	"533.3"	"1200.0"	"1204.8"	"690.5"	"805.6"	"1024.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75390"	"Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2"	"17"	"8"	"23"	"8"	"466"	"51.7"	"8.32"	"4681.62"	"35.45"	"8"	"8"	"other metabolic processes"	"mitochondrion"	"other molecular function"	"Pf00285"	"1431"	"ENSG00000062485"	"CS"	"hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8"	"TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)"	"Citric acid cycle (TCA cycle); Mitochondrial protein import"	"6"	"0"	"1177.6"	"838.8"	"1232.9"	"1594.0"	"1909.6"	"1704.7"	"2697.7"	"2602.0"	"1729.7"	"2007.3"	"2791.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P39687"	"Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1"	"28"	"7"	"18"	"5"	"249"	"28.6"	"4.09"	"3118.32"	"35.25"	"6"	"6"	"transport;signal transduction;other biological processes"	"ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf14580"	"8125"	"ENSG00000140350"	"ANP32A"	"B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6"	"IL-18 signaling pathway"	"HuR (ELAVL1) binds and stabilizes mRNA"	"2"	"2"	"614.8"	"430.9"	"554.1"	"707.4"	"840.6"	"726.1"	"2325.2"	"2312.6"	"1501.3"	"1665.9"	"2412.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06454"	"Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2"	"23"	"4"	"18"	"4"	"111"	"12.2"	"3.78"	"4063.95"	"34.96"	"4"	"4"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf03247"	"5757"	"ENSG00000187514"	"PTMA"	"hsa:5757; P06454; Q15249; Q15592"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"249.9"	"185.3"	"228.8"	"245.4"	"306.3"	"297.8"	"543.5"	"532.1"	"395.7"	"391.0"	"551.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P48735"	"Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2"	"25"	"10"	"21"	"10"	"452"	"50.9"	"8.69"	"3983.73"	"34.90"	"10"	"9"	"other metabolic processes"	"cytosol;mitochondrion;other cytoplasmic organelle"	"other molecular function"	"Pf00180"	"3418"	"ENSG00000182054"	"IDH2"	"B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3"	"VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)"	"Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle)"	"6"	"0"	"357.7"	"228.7"	"361.8"	"430.7"	"512.1"	"516.1"	"1309.1"	"1249.6"	"870.0"	"955.1"	"1436.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46781"	"40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3"	"39"	"12"	"27"	"12"	"194"	"22.6"	"10.65"	"4677.29"	"34.88"	"11"	"11"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00163, Pf01479"	"6203"	"ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270"	"RPS9"	"A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"20"	"0"	"1020.1"	"706.6"	"989.4"	"1235.8"	"1583.1"	"1456.9"	"4797.0"	"4603.4"	"2564.5"	"3441.3"	"5504.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12277"	"Creatine kinase B-type OS=Homo sapiens OX=9606 GN=CKB PE=1 SV=1"	"27"	"8"	"14"	"8"	"381"	"42.6"	"5.59"	"1651.97"	"34.88"	"5"	"8"	"other metabolic processes;developmental processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00217, Pf02807"	"1152"	"ENSG00000166165"	"CKB"	"A8K236; B2R5R4; hsa:1152; P12277; Q2LE07; Q6FG40; Q9UC66"	""	"RND3 GTPase cycle; Creatine metabolism"	"2"	"0"	"257.7"	"227.8"	"284.7"	"335.5"	"426.8"	"473.1"	"683.8"	"616.0"	"378.4"	"616.5"	"1075.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86YS7"	"C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1"	"14"	"13"	"24"	"13"	"1000"	"110.4"	"5.69"	"4095.27"	"34.79"	"12"	"11"	"transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00168"	"9847"	"ENSG00000111731"	"C2CD5"	"B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7"	""	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"	"1"	"0"	"407.5"	"270.0"	"336.7"	"458.8"	"530.1"	"478.4"	"1737.6"	"3996.9"	"3632.2"	"5125.5"	"6390.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43143"	"Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2"	"13"	"11"	"23"	"11"	"795"	"90.9"	"7.46"	"4130.16"	"34.74"	"10"	"9"	"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf04408, Pf07717"	"1665"	"ENSG00000109606"	"DHX15"	"hsa:1665; O43143; Q9NQT7"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"384.2"	"277.4"	"388.6"	"487.5"	"676.9"	"580.0"	"1423.1"	"1320.4"	"848.4"	"1263.7"	"1527.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62701"	"40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2"	"33"	"10"	"26"	"10"	"263"	"29.6"	"10.15"	"3907.26"	"34.68"	"9"	"9"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00467, Pf00900, Pf01479, Pf08071, Pf16121"	"6191"	"ENSG00000198034"	"RPS4X"	"hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"1307.5"	"878.0"	"1235.1"	"1377.3"	"1656.8"	"1475.6"	"4685.1"	"4309.7"	"2751.3"	"3403.5"	"4143.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6NSI4"	"RPA-related protein RADX OS=Homo sapiens OX=9606 GN=RADX PE=1 SV=2"	"12"	"9"	"22"	"9"	"855"	"97.5"	"8.41"	"4017.26"	"34.66"	"9"	"9"	"other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf17659"	"55086"	"ENSG00000147231"	"RADX"	"H7BY89; hsa:55086; Q4G0L7; Q5JQS1; Q5JRF9; Q6NSI4; Q6PHY5; Q6PII9; Q6PJU8; Q9H7W5; Q9NWA6"	""	""	"0"	"0"	"258.3"	"164.7"	"243.8"	"324.5"	"390.4"	"342.6"	"1199.2"	"1135.1"	"772.3"	"914.8"	"1267.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UQ35"	"Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2"	"6"	"10"	"17"	"10"	"2752"	"299.4"	"12.06"	"2797.46"	"34.41"	"7"	"10"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf08312"	"23524"	"ENSG00000167978"	"SRRM2"	"A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"585.8"	"341.9"	"495.8"	"631.2"	"789.0"	"735.3"	"2339.8"	"1858.7"	"1228.4"	"2254.5"	"2561.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55265"	"Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4"	"9"	"11"	"26"	"11"	"1226"	"136.0"	"8.65"	"4291.20"	"34.38"	"9"	"9"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00035, Pf02137, Pf02295"	"103"	"ENSG00000160710"	"ADAR"	"B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4"	"Measles virus infection; Cytosolic DNA-sensing pathway"	"Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins"	"5"	"0"	"760.1"	"493.6"	"666.5"	"867.9"	"1183.5"	"969.8"	"2327.5"	"2127.3"	"1176.0"	"1748.2"	"2476.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HB71"	"Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2"	"41"	"8"	"22"	"8"	"228"	"26.2"	"8.25"	"4068.98"	"34.32"	"8"	"8"	"developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf04969, Pf05002, Pf09032"	"27101"	"ENSG00000116161"	"CACYBP"	"B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71"	"Gastric cancer network 2"	""	"1"	"0"	"281.4"	"172.9"	"268.0"	"361.8"	"472.9"	"428.2"	"2855.0"	"3085.0"	"1798.3"	"3265.0"	"7637.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14566"	"DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1"	"16"	"13"	"23"	"13"	"821"	"92.8"	"5.41"	"4165.64"	"34.31"	"12"	"11"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00493, Pf14551, Pf17207, Pf17855, Pf18263"	"4175"	"ENSG00000076003"	"MCM6"	"B2R6H2; hsa:4175; Q13504; Q14566; Q99859"	"Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication"	"Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA"	"11"	"0"	"797.2"	"621.9"	"890.6"	"1098.0"	"1340.6"	"1356.6"	"2253.7"	"2132.1"	"1307.2"	"1867.2"	"2431.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35527"	"Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3"	"26"	"13"	"25"	"12"	"623"	"62.0"	"5.24"	"5125.03"	"34.29"	"12"	"10"	"cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton"	"cytoskeletal activity"	"Pf00038"	"3857"	"ENSG00000171403"	"KRT9"	"hsa:3857; O00109; P35527; Q0IJ47; Q14665"	""	"Formation of the cornified envelope"	"2"	"0"	"3380.5"	"487.1"	"182.6"	"448.4"	"3201.9"	"1341.6"	"3327.6"	"1100.9"	"662.5"	"2829.0"	"2014.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62263"	"40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3"	"39"	"6"	"14"	"6"	"151"	"16.3"	"10.05"	"2248.98"	"33.98"	"5"	"6"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00411"	"6208"	"ENSG00000164587"	"RPS14"	"B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"20"	"0"	"330.5"	"247.1"	"336.0"	"360.0"	"468.3"	"389.0"	"1159.8"	"1029.9"	"755.3"	"938.8"	"1165.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62249"	"40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2"	"57"	"9"	"24"	"9"	"146"	"16.4"	"10.21"	"4138.66"	"33.93"	"8"	"9"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00380"	"6217"	"ENSG00000105193"	"RPS16"	"B2RDD5; hsa:6217; P17008; P62249"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery"	"19"	"0"	"1090.9"	"765.6"	"911.0"	"1098.2"	"1395.2"	"1184.6"	"4056.3"	"3863.6"	"2776.1"	"3172.7"	"4418.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H307"	"Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5"	"14"	"8"	"19"	"8"	"717"	"81.6"	"7.14"	"4123.01"	"33.77"	"8"	"7"	"cell adhesion;RNA metabolism OR transcription;other metabolic processes"	"plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04696, Pf04697"	"5411"	"ENSG00000100941"	"PNN"	"B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"228.7"	"118.2"	"187.1"	"257.1"	"326.1"	"302.5"	"641.4"	"538.3"	"357.6"	"701.7"	"930.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P67809"	"Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3"	"38"	"9"	"18"	"6"	"324"	"35.9"	"9.88"	"3387.68"	"33.60"	"7"	"7"	"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00313"	"4904"	"ENSG00000065978"	"YBX1"	"hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0"	"Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; Noncanonical activation of NOTCH3"	"10"	"3"	"469.0"	"259.4"	"424.0"	"526.3"	"655.5"	"590.3"	"1515.7"	"1294.7"	"707.2"	"1039.4"	"1260.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60216"	"Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2"	"17"	"9"	"19"	"9"	"631"	"71.6"	"4.65"	"3161.74"	"33.59"	"7"	"8"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04824, Pf04825"	"5885"	"ENSG00000164754"	"RAD21"	"A8K0E0; hsa:5885; O60216; Q15001; Q99568"	"Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation"	"Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin"	"13"	"0"	"400.0"	"290.1"	"414.9"	"615.1"	"772.7"	"593.2"	"1724.3"	"1653.0"	"1018.7"	"1452.9"	"1952.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96I25"	"Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1"	"25"	"10"	"23"	"9"	"401"	"44.9"	"5.97"	"4765.56"	"33.48"	"10"	"8"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076, Pf01585"	"84991"	"ENSG00000134453"	"RBM17"	"hsa:84991; Q96GY6; Q96I25"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"1"	"469.6"	"265.0"	"374.6"	"515.5"	"709.4"	"601.7"	"1197.4"	"1242.3"	"777.0"	"980.2"	"1277.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZW5"	"MAGUK p55 subfamily member 6 OS=Homo sapiens OX=9606 GN=MPP6 PE=1 SV=2"	"24"	"12"	"24"	"11"	"540"	"61.1"	"6.18"	"4004.53"	"33.48"	"12"	"12"	"cell organization and biogenesis"	"plasma membrane;other membranes;other cell component"	""	"Pf00595, Pf00625, Pf02828, Pf07653"	"51678"	"ENSG00000105926"	"PALS2"	"A4D157; hsa:51678; Q9H0E1; Q9NZW5"	""	""	"0"	"1"	"474.9"	"326.9"	"467.7"	"749.9"	"918.1"	"767.5"	"1847.2"	"1920.1"	"1180.6"	"1491.0"	"1907.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11171"	"Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4"	"10"	"8"	"19"	"8"	"864"	"97.0"	"5.58"	"3851.79"	"33.42"	"8"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380"	"2035"	"ENSG00000159023"	"EPB41"	"B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579"	"VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway"	"Neurexins and neuroligins"	"4"	"0"	"429.3"	"275.7"	"418.9"	"629.0"	"776.6"	"659.4"	"1990.8"	"1991.8"	"1261.3"	"2050.9"	"3749.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y383"	"Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2"	"22"	"9"	"21"	"6"	"392"	"46.5"	"10.01"	"4099.27"	"33.42"	"9"	"9"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf03194"	"51631"	"ENSG00000146963"	"LUC7L2"	"B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383"	""	""	"0"	"3"	"544.2"	"385.4"	"536.2"	"701.2"	"884.3"	"782.2"	"2895.5"	"2622.7"	"1365.7"	"1951.4"	"2499.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82979"	"SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3"	"34"	"7"	"19"	"7"	"210"	"23.7"	"6.42"	"4025.77"	"33.38"	"6"	"7"	"other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02037"	"84324"	"ENSG00000205323"	"SARNP"	"A8K393; hsa:84324; P82979; Q9P066"	""	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"3"	"0"	"704.2"	"455.0"	"722.8"	"1039.4"	"1194.2"	"1190.5"	"3638.2"	"3425.2"	"2494.6"	"3085.9"	"4143.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05114"	"Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3"	"55"	"6"	"19"	"6"	"100"	"10.7"	"9.60"	"3369.86"	"33.29"	"5"	"6"	"cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01101"	"3150"	"ENSG00000205581"	"HMGN1"	"hsa:3150; P05114; Q3KQR8"	"ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum"	"Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER"	"8"	"0"	"505.4"	"226.0"	"376.4"	"473.7"	"602.4"	"583.3"	"3175.6"	"3086.8"	"1896.3"	"2645.9"	"4176.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NR30"	"Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5"	"15"	"11"	"22"	"11"	"783"	"87.3"	"9.28"	"4460.68"	"33.16"	"11"	"9"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf08152"	"9188"	"ENSG00000165732"	"DDX21"	"B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30"	"10q11.21q11.23 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol"	"3"	"0"	"281.6"	"151.4"	"248.9"	"301.6"	"413.2"	"336.2"	"1213.7"	"1155.8"	"612.4"	"919.3"	"1344.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16531"	"DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1"	"9"	"11"	"22"	"11"	"1140"	"126.9"	"5.26"	"3230.13"	"33.02"	"10"	"11"	"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03178, Pf10433"	"1642"	"ENSG00000167986"	"DDB1"	"A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96"	"Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER"	"14"	"0"	"708.7"	"555.4"	"694.6"	"913.8"	"1058.9"	"1015.7"	"1834.7"	"1838.6"	"1235.1"	"1622.9"	"2493.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P15924"	"Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3"	"5"	"12"	"21"	"12"	"2871"	"331.6"	"6.81"	"3183.25"	"32.94"	"10"	"11"	"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00681, Pf17902, Pf18373"	"1832"	"ENSG00000096696"	"DSP"	"B2RTT2; D7RX09; hsa:1832; O75993; P15924; Q14189; Q9UHN4"	"Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer"	"Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion  proteins"	"9"	"0"	"499.7"	"307.9"	"438.2"	"531.9"	"703.2"	"575.9"	"867.9"	"1107.8"	"613.0"	"809.4"	"1230.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q09028"	"Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3"	"26"	"11"	"23"	"4"	"425"	"47.6"	"4.89"	"3628.90"	"32.70"	"10"	"9"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00400, Pf12265"	"5928"	"ENSG00000162521"	"RBBP4"	"B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9"	"Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development"	"RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"	"28"	"8"	"1009.5"	"710.0"	"1022.4"	"1458.5"	"1651.1"	"1535.3"	"3037.5"	"3043.8"	"1838.8"	"2282.9"	"3086.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P40227"	"T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3"	"23"	"10"	"19"	"10"	"531"	"58.0"	"6.68"	"3136.16"	"32.58"	"8"	"10"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00118"	"908"	"ENSG00000146731"	"CCT6A"	"A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46"	"16p11.2 proximal deletion syndrome"	"Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC"	"7"	"0"	"735.7"	"586.8"	"801.1"	"1096.7"	"1302.9"	"1266.8"	"1870.3"	"1775.9"	"1083.2"	"1448.2"	"2152.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95232"	"Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2"	"21"	"10"	"19"	"10"	"432"	"51.4"	"9.79"	"3033.01"	"32.50"	"8"	"10"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf03194"	"51747"	"ENSG00000108848"	"LUC7L3"	"B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"825.6"	"471.7"	"700.1"	"853.2"	"1219.4"	"1045.7"	"3195.4"	"2927.9"	"1456.7"	"2690.7"	"3690.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P32119"	"Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5"	"33"	"8"	"20"	"7"	"198"	"21.9"	"5.97"	"4989.10"	"32.45"	"8"	"7"	"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00578, Pf10417"	"7001"	"ENSG00000167815"	"PRDX2"	"A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23"	"Selenium micronutrient network; VEGFA-VEGFR2 signaling"	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes"	"5"	"0"	"500.1"	"333.0"	"461.8"	"726.2"	"943.0"	"858.5"	"1566.0"	"1546.9"	"969.8"	"1376.6"	"2356.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30101"	"Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4"	"21"	"9"	"17"	"9"	"505"	"56.7"	"6.35"	"2894.50"	"32.22"	"7"	"8"	"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00085, Pf13848"	"2923"	"ENSG00000167004"	"PDIA3"	"hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7"	"Prion disease pathway"	"ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle"	"4"	"0"	"384.6"	"323.1"	"451.3"	"514.3"	"626.7"	"580.8"	"1479.1"	"1446.6"	"970.4"	"1248.7"	"1742.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62277"	"40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2"	"52"	"10"	"22"	"10"	"151"	"17.2"	"10.54"	"3438.28"	"32.14"	"9"	"8"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00312, Pf08069"	"6207"	"ENSG00000110700"	"RPS13"	"B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0"	"Cytoplasmic ribosomal proteins"	"Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"948.4"	"655.1"	"866.3"	"1100.8"	"1317.2"	"1174.7"	"3525.7"	"3348.5"	"1968.9"	"2634.9"	"3995.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H078"	"Caseinolytic peptidase B protein homolog OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1"	"18"	"8"	"13"	"8"	"707"	"78.7"	"9.01"	"2048.41"	"31.84"	"5"	"8"	"stress response;signal transduction;other biological processes"	"mitochondrion;other cell component"	"other molecular function"	"Pf07724, Pf10431, Pf12796, Pf13857"	"81570"	"ENSG00000162129"	"CLPB"	"B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0"	""	""	"0"	"0"	"102.6"	"91.1"	"102.5"	"139.2"	"179.9"	"147.8"	"990.1"	"1079.5"	"867.8"	"1308.7"	"2029.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16576"	"Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1"	"19"	"9"	"23"	"3"	"425"	"47.8"	"5.05"	"3968.41"	"31.75"	"9"	"8"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00400, Pf12265"	"5931"	"ENSG00000102054"	"RBBP7"	"hsa:5931; Q16576; Q5JP00"	"Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome"	"HCMV Early Events; Neddylation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation"	"20"	"0"	"89.0"	"68.8"	"97.4"	"140.6"	"151.2"	"136.5"	"321.3"	"343.4"	"239.9"	"302.8"	"298.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P36873"	"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1"	"29"	"7"	"15"	"2"	"323"	"37.0"	"6.54"	"3006.90"	"31.68"	"6"	"7"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00149, Pf16891"	"5501"	"ENSG00000186298"	"PPP1CC"	"hsa:5501; P36873"	"Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling"	"16"	"0"	"102.1"	"81.2"	"110.7"	"133.3"	"157.8"	"130.7"	"842.4"	"890.2"	"542.1"	"611.1"	"651.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60256"	"Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1"	"25"	"9"	"20"	"7"	"369"	"40.9"	"7.44"	"3406.90"	"31.51"	"9"	"8"	"other metabolic processes;developmental processes"	"other cell component"	"enzyme regulator activity;other molecular function"	"Pf13793, Pf14572"	"5636"	"ENSG00000141127"	"PRPSAP2"	"B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2"	""	""	"0"	"1"	"321.5"	"252.2"	"368.8"	"571.8"	"676.1"	"629.4"	"1082.3"	"1230.7"	"949.7"	"1367.8"	"2150.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TBX8"	"Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3"	"19"	"8"	"19"	"8"	"421"	"47.3"	"6.84"	"3341.91"	"31.48"	"7"	"8"	"other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"kinase activity;other molecular function"	"Pf01504"	"79837"	"ENSG00000166908"	"PIP4K2C"	"B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2"	"Regulation of actin cytoskeleton"	"Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus"	"5"	"0"	"88.8"	"64.9"	"104.6"	"110.4"	"166.8"	"150.8"	"521.7"	"758.3"	"713.6"	"1204.9"	"1614.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08559"	"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3"	"26"	"12"	"24"	"12"	"390"	"43.3"	"8.06"	"4180.80"	"31.26"	"11"	"11"	"other metabolic processes"	"mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00676"	"5160"	"ENSG00000131828"	"PDHA1"	"A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5"	"TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid"	"15"	"0"	"1009.8"	"711.3"	"1012.8"	"1147.4"	"1326.9"	"1241.0"	"2631.0"	"2707.3"	"1933.8"	"2275.9"	"2803.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35232"	"Prohibitin OS=Homo sapiens OX=9606 GN=PHB PE=1 SV=1"	"37"	"9"	"21"	"9"	"272"	"29.8"	"5.76"	"4424.47"	"31.20"	"8"	"8"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf01145"	"5245"	"ENSG00000167085"	"PHB1"	"B4DY47; hsa:5245; P35232; Q4VBQ0"	""	"Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; RAF activation; Processing of SMDT1"	"5"	"0"	"645.5"	"452.5"	"533.7"	"657.0"	"907.6"	"711.6"	"1580.6"	"1367.6"	"744.5"	"1126.6"	"1324.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6PI48"	"Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1"	"14"	"9"	"19"	"8"	"645"	"73.5"	"8.02"	"3614.63"	"31.14"	"8"	"8"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"mitochondrion;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00152, Pf01336, Pf02938"	"55157"	"ENSG00000117593"	"DARS2"	"hsa:55157; Q6PI48"	""	"Mitochondrial tRNA aminoacylation"	"1"	"0"	"313.5"	"199.9"	"313.5"	"410.4"	"541.9"	"481.3"	"2503.2"	"2434.0"	"1655.4"	"1957.5"	"2764.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3I0"	"RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1"	"24"	"10"	"18"	"10"	"505"	"55.2"	"7.23"	"2521.86"	"31.14"	"7"	"9"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf01139"	"51493"	"ENSG00000100220"	"RTCB"	"B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0"	"Unfolded protein response"	"tRNA processing in the nucleus"	"2"	"0"	"523.3"	"307.0"	"526.6"	"631.2"	"821.4"	"708.3"	"2129.5"	"2028.6"	"1319.8"	"1533.3"	"1925.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14554"	"Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1"	"19"	"8"	"17"	"8"	"519"	"59.6"	"7.91"	"2872.18"	"31.05"	"7"	"8"	"protein metabolism;other metabolic processes"	"other membranes;ER/Golgi"	"other molecular function"	"Pf00085"	"10954"	"ENSG00000065485"	"PDIA5"	"D3DN95; hsa:10954; Q14554; Q9BV43"	""	"XBP1(S) activates chaperone genes"	"1"	"0"	"127.8"	"92.8"	"130.8"	"184.7"	"215.1"	"189.0"	"712.8"	"889.7"	"1153.7"	"1997.2"	"3121.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62140"	"Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3"	"30"	"7"	"15"	"1"	"327"	"37.2"	"6.19"	"3019.87"	"31.05"	"6"	"7"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00149, Pf16891"	"5500"	"ENSG00000213639"	"PPP1CB"	"B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45"	"Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway"	"RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling"	"18"	"0"	"9.9"	"6.1"	"11.6"	"15.1"	"14.4"	"14.4"	"35.2"	"38.4"	"28.3"	"30.7"	"37.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13573"	"SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1"	"20"	"11"	"19"	"11"	"536"	"61.5"	"9.52"	"3320.91"	"31.05"	"8"	"10"	"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus"	"signal transduction activity or receptor binding;other molecular function"	"Pf02731"	"22938"	"ENSG00000100603"	"SNW1"	"A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6"	"Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway"	"mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling"	"15"	"0"	"479.8"	"321.2"	"439.3"	"560.7"	"711.5"	"637.0"	"1781.4"	"1627.6"	"1138.2"	"1577.1"	"1889.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63279"	"SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1"	"40"	"8"	"17"	"8"	"158"	"18.0"	"8.66"	"3609.79"	"31.02"	"8"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00179"	"7329"	"ENSG00000103275"	"UBE2I"	"D3DU69; hsa:7329; P50550; P63279; Q15698; Q59GX1; Q86VB3"	"Androgen receptor signaling pathway; TAR syndrome"	"SUMOylation of RNA binding proteins; Formation of Incision Complex in GG-NER; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; Postmitotic nuclear pore complex (NPC) reformation; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Meiotic synapsis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)"	"25"	"0"	"224.2"	"151.0"	"294.5"	"412.8"	"457.0"	"448.8"	"934.5"	"1059.1"	"804.1"	"1157.8"	"2853.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKM9"	"RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1"	"31"	"9"	"20"	"9"	"306"	"32.4"	"9.17"	"3889.66"	"30.95"	"8"	"7"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf00076"	"22913"	"ENSG00000125970"	"RALY"	"hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9"	""	""	"0"	"0"	"1208.9"	"670.5"	"1076.8"	"1460.1"	"1854.8"	"1600.0"	"3475.6"	"2850.7"	"1489.9"	"2461.3"	"3901.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92945"	"Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4"	"17"	"9"	"17"	"6"	"711"	"73.1"	"7.30"	"2741.49"	"30.90"	"7"	"8"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf09005"	"8570"	"ENSG00000088247"	"KHSRP"	"hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5"	"Pre-implantation embryo"	"ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA"	"3"	"0"	"324.9"	"239.5"	"294.7"	"434.2"	"544.2"	"438.5"	"1035.1"	"907.0"	"633.0"	"888.6"	"932.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07237"	"Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3"	"19"	"9"	"18"	"9"	"508"	"57.1"	"4.87"	"2662.45"	"30.85"	"7"	"9"	"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00085, Pf13848"	"5034"	"ENSG00000185624"	"P4HB"	"B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5"	"VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta"	"Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling; Chylomicron assembly; VLDL assembly; LDL remodeling"	"13"	"0"	"553.8"	"429.1"	"663.3"	"932.9"	"1055.9"	"977.5"	"1742.7"	"1721.7"	"1067.1"	"1476.9"	"2154.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y262"	"Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1"	"17"	"8"	"19"	"8"	"564"	"66.7"	"6.34"	"3160.46"	"30.71"	"7"	"7"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity"	"Pf10255"	"51386"	"ENSG00000100129"	"EIF3L"	"B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262"	""	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition"	"6"	"0"	"564.3"	"383.1"	"542.6"	"823.9"	"981.0"	"835.4"	"1842.8"	"1894.3"	"1258.2"	"1629.2"	"2777.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZI8"	"Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2"	"16"	"8"	"17"	"7"	"577"	"63.4"	"9.20"	"3499.55"	"30.50"	"8"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf00076"	"10642"	"ENSG00000159217"	"IGF2BP1"	"C9JT33; hsa:10642; Q9NZI8"	"Brain-derived neurotrophic factor (BDNF) signaling pathway; eIF5A regulation in response to inhibition of the nuclear export system"	"MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"	"4"	"1"	"479.3"	"299.6"	"464.5"	"593.9"	"773.1"	"676.3"	"1716.2"	"1503.9"	"902.9"	"1307.9"	"1862.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P84103"	"Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1"	"45"	"8"	"17"	"8"	"164"	"19.3"	"11.65"	"2791.24"	"30.47"	"6"	"7"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"6428"	"ENSG00000112081"	"SRSF3"	"B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"6"	"0"	"962.5"	"679.4"	"779.4"	"994.7"	"1323.6"	"1026.0"	"4299.9"	"3924.2"	"2688.3"	"3001.4"	"2736.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06899"	"Histone H2B type 1-J OS=Homo sapiens OX=9606 GN=H2BC11 PE=1 SV=3"	"36"	"5"	"17"	"2"	"126"	"13.9"	"10.32"	"3667.41"	"30.46"	"5"	"4"	"cell organization and biogenesis;stress response;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00125"	"8970"	"ENSG00000124635"	"H2BC11"	"B2R4J4; hsa:8970; O60816; P06899"	""	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Deposition of new CENPA-containing nucleosomes at the centromere; E3 ubiquitin ligases ubiquitinate target proteins; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis"	"43"	"0"	"107.9"	"73.6"	"100.8"	"119.8"	"141.6"	"125.5"	"527.4"	"435.1"	"515.3"	"616.6"	"645.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12081"	"Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2"	"22"	"12"	"18"	"12"	"509"	"57.4"	"5.88"	"2588.76"	"30.46"	"7"	"9"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00458, Pf03129, Pf13393"	"3035"	"ENSG00000170445"	"HARS1"	"B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081"	"Allograft rejection"	"Cytosolic tRNA aminoacylation"	"2"	"0"	"349.7"	"273.4"	"369.8"	"479.1"	"599.9"	"540.1"	"1400.5"	"1605.1"	"1575.8"	"2861.2"	"6223.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96T37"	"RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2"	"11"	"9"	"17"	"8"	"977"	"107.1"	"10.08"	"2890.54"	"30.42"	"7"	"8"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"other membranes;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf07744"	"64783"	"ENSG00000162775"	"RBM15"	"A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0"	""	""	"0"	"1"	"205.7"	"121.6"	"193.7"	"253.9"	"326.6"	"285.4"	"1442.0"	"2258.1"	"1669.8"	"3415.2"	"4731.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01844"	"RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1"	"14"	"6"	"16"	"6"	"656"	"68.4"	"9.33"	"2414.76"	"30.35"	"4"	"6"	"other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	"other molecular function"	"Pf00076, Pf00641"	"2130"	"ENSG00000182944"	"EWSR1"	"B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"377.9"	"335.5"	"358.8"	"433.5"	"526.3"	"453.9"	"1359.9"	"1283.3"	"1140.9"	"997.1"	"1192.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6UN15"	"Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1"	"18"	"8"	"21"	"8"	"594"	"66.5"	"5.59"	"4128.46"	"30.29"	"8"	"7"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus"	""	"Pf05182"	"81608"	"ENSG00000145216"	"FIP1L1"	"B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077"	""	"Transport of Mature mRNA Derived from an Intronless Transcript; RNA Polymerase II Transcription Termination; mRNA 3'-end processing; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins"	"6"	"0"	"509.6"	"371.3"	"500.5"	"740.7"	"833.8"	"767.0"	"1640.1"	"1634.8"	"1163.7"	"1451.8"	"1761.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60814"	"Histone H2B type 1-K OS=Homo sapiens OX=9606 GN=H2BC12 PE=1 SV=3"	"36"	"5"	"17"	"2"	"126"	"13.9"	"10.32"	"3727.52"	"30.25"	"5"	"4"	"stress response;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00125"	"85236"	"ENSG00000197903"	"H2BC12"	"A8K7P7; hsa:85236; O60814; Q2VPI7"	""	"Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; E3 ubiquitin ligases ubiquitinate target proteins; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HATs acetylate histones; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis"	"43"	"6"	"454.8"	"412.1"	"455.1"	"466.3"	"576.5"	"534.9"	"2215.9"	"1985.8"	"2348.9"	"2374.0"	"2205.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13242"	"Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1"	"45"	"11"	"22"	"10"	"221"	"25.5"	"8.65"	"4362.47"	"30.21"	"9"	"10"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf00076"	"8683"	"ENSG00000111786"	"SRSF9"	"hsa:8683; Q13242; Q52LD1"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"6"	"1"	"1099.7"	"891.4"	"1176.1"	"1538.3"	"1794.9"	"1456.6"	"3488.0"	"3119.3"	"1823.1"	"2189.3"	"2166.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62826"	"GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3"	"36"	"6"	"15"	"6"	"216"	"24.4"	"7.49"	"2062.11"	"30.19"	"5"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00071"	"5901"	"ENSG00000132341"	"RAN"	"A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9"	"Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome"	"Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation"	"11"	"0"	"561.3"	"526.4"	"657.2"	"804.6"	"906.3"	"908.2"	"1439.7"	"1478.7"	"1237.1"	"1284.2"	"1799.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P57721"	"Poly(rC)-binding protein 3 OS=Homo sapiens OX=9606 GN=PCBP3 PE=1 SV=2"	"21"	"7"	"16"	"1"	"371"	"39.4"	"8.07"	"3524.02"	"30.01"	"6"	"7"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013"	"54039"	"ENSG00000183570"	"PCBP3"	"A8MPS2; A8MQ26; B7WNN9; B7WPC1; hsa:54039; P57721; Q8N9K6; Q96EP6"	""	""	"0"	"0"	"22.2"	"12.5"	"28.7"	"23.2"	"47.4"	"37.8"	"96.0"	"100.4"	"64.0"	"86.5"	"88.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5VT25"	"Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1"	"7"	"9"	"16"	"9"	"1732"	"197.2"	"6.58"	"2910.41"	"29.98"	"8"	"8"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;other cell component"	"kinase activity;other molecular function"	"Pf00069, Pf00130, Pf00433, Pf00780, Pf08826, Pf15796"	"8476"	"ENSG00000143776"	"CDC42BPA"	"hsa:8476; O75039; Q59GZ1; Q5H9N9; Q5T797; Q5VT25; Q5VT26; Q5VT27; Q86XX2; Q86XX3; Q99646"	"Male infertility"	"CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle"	"5"	"0"	"159.1"	"120.6"	"160.1"	"220.3"	"282.1"	"237.1"	"671.1"	"964.4"	"870.6"	"1109.2"	"1195.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WUM0"	"Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2"	"9"	"10"	"20"	"10"	"1156"	"128.9"	"5.10"	"3617.85"	"29.79"	"9"	"10"	"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes"	"other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf03177"	"55746"	"ENSG00000069248"	"NUP133"	"B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4"	"Ciliary landscape"	"HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"36"	"0"	"587.3"	"403.7"	"622.1"	"1213.8"	"1388.2"	"1123.9"	"1971.6"	"1929.9"	"989.4"	"1414.7"	"1571.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75821"	"Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2"	"21"	"7"	"14"	"7"	"320"	"35.6"	"6.13"	"2365.53"	"29.62"	"6"	"7"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf12353"	"8666"	"ENSG00000130811"	"EIF3G"	"hsa:8666; O14801; O75821; Q969U5"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"8"	"0"	"774.1"	"489.4"	"704.8"	"833.0"	"994.3"	"916.9"	"2336.7"	"2092.1"	"1324.5"	"1622.2"	"2271.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06753"	"Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2"	"27"	"8"	"22"	"4"	"285"	"32.9"	"4.72"	"3637.87"	"29.59"	"8"	"7"	"cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton"	"cytoskeletal activity"	"Pf00261"	"7170"	"ENSG00000143549"	"TPM3"	"D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8"	"Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling"	"Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction"	"7"	"4"	"1295.0"	"826.8"	"1321.9"	"1949.5"	"2356.2"	"2207.4"	"4013.3"	"3895.2"	"2278.0"	"2812.3"	"4535.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12955"	"Ankyrin-3 OS=Homo sapiens OX=9606 GN=ANK3 PE=1 SV=3"	"3"	"10"	"18"	"10"	"4377"	"480.1"	"6.49"	"2541.40"	"29.56"	"8"	"10"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00531, Pf00791, Pf12796, Pf17809"	"288"	"ENSG00000151150"	"ANK3"	"B1AQT2; B4DIL1; E9PE32; hsa:288; Q12955; Q13484; Q5CZH9; Q5VXD5; Q7Z3G4; Q9H0P5"	"Splicing factor NOVA regulated synaptic proteins"	"COPI-mediated anterograde transport; Interaction between L1 and Ankyrins"	"3"	"0"	"190.2"	"146.5"	"223.3"	"329.6"	"388.1"	"326.3"	"1030.5"	"929.9"	"741.1"	"886.0"	"973.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15046"	"Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3"	"15"	"7"	"15"	"7"	"597"	"68.0"	"6.35"	"2591.77"	"29.49"	"5"	"7"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00152, Pf01336"	"3735"	"ENSG00000065427"	"KARS1"	"A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23"	""	"Cytosolic tRNA aminoacylation; Selenoamino acid metabolism; Mitochondrial tRNA aminoacylation"	"3"	"0"	"239.8"	"156.1"	"287.0"	"366.1"	"490.5"	"440.3"	"1488.9"	"1545.6"	"941.1"	"1257.8"	"1679.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P47985"	"Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2"	"34"	"9"	"16"	"9"	"274"	"29.6"	"8.32"	"2333.64"	"29.41"	"7"	"9"	"cell organization and biogenesis;other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf00355, Pf02921, Pf09165"	"7386"	"ENSG00000169021"	"UQCRFS1"	"A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation"	"Respiratory electron transport"	"6"	"0"	"575.4"	"370.3"	"562.1"	"1031.2"	"1193.5"	"967.2"	"2197.6"	"2143.4"	"1461.8"	"1808.6"	"2803.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62979"	"Ubiquitin-40S ribosomal protein S27a OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2"	"52"	"7"	"17"	"7"	"156"	"18.0"	"9.64"	"2743.13"	"29.32"	"5"	"6"	"protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00240, Pf01599"	"6233"	"ENSG00000143947"	"RPS27A"	"hsa:6233; P02248; P02249; P02250; P14798; P62979; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BQ77; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7"	"Cytoplasmic ribosomal proteins"	"Oxidative Stress Induced Senescence; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Orc1 removal from chromatin; Assembly of the pre-replicative complex; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation  ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Formation of Incision Complex in GG-NER; Iron uptake and transport; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"	"201"	"0"	"1085.5"	"875.3"	"1121.9"	"1285.3"	"1530.5"	"1474.8"	"2841.8"	"2546.9"	"1867.3"	"2424.9"	"3156.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62753"	"40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1"	"26"	"8"	"24"	"8"	"249"	"28.7"	"10.84"	"4241.56"	"29.21"	"8"	"6"	"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01092"	"6194"	"ENSG00000137154"	"RPS6"	"hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7"	"IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; A network map of Macrophage-stimulating protein (MSP) signaling; Interferon type I signaling pathways"	"Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; rRNA modification in the nucleus and cytosol; Nuclear events stimulated by ALK signaling in cancer; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"47"	"0"	"1085.0"	"598.5"	"858.6"	"1002.9"	"1190.5"	"1049.7"	"3952.0"	"3490.1"	"2351.9"	"2681.0"	"3106.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5JSL3"	"Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2"	"7"	"11"	"20"	"10"	"2073"	"237.5"	"7.74"	"4960.11"	"29.16"	"10"	"9"	"signal transduction;other biological processes"	"cytosol"	"enzyme regulator activity;other molecular function"	"Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422"	"139818"	"ENSG00000147251"	"DOCK11"	"A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3"	""	"CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production"	"3"	"1"	"160.7"	"109.1"	"181.5"	"224.9"	"298.2"	"261.6"	"910.8"	"1047.7"	"1421.0"	"2441.7"	"2557.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P16152"	"Carbonyl reductase [NADPH] 1 OS=Homo sapiens OX=9606 GN=CBR1 PE=1 SV=3"	"35"	"8"	"17"	"8"	"277"	"30.4"	"8.32"	"2428.47"	"29.12"	"6"	"8"	"other metabolic processes;other biological processes"	"cytosol"	"other molecular function"	"Pf00106"	"873"	"ENSG00000159228"	"CBR1"	"B2RBZ7; B4DFK7; hsa:873; P16152; Q3LHW8"	"Nuclear receptors meta-pathway; NRF2 pathway; Prostaglandin synthesis and regulation"	"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"	"4"	"0"	"272.3"	"262.0"	"304.6"	"413.7"	"438.8"	"427.0"	"650.3"	"623.7"	"491.8"	"563.8"	"930.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60716"	"Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1"	"8"	"8"	"18"	"8"	"968"	"108.1"	"6.23"	"3491.98"	"29.11"	"7"	"7"	"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00514"	"1500"	"ENSG00000198561"	"CTNND1"	"A8K939; hsa:1500; O15088; O60713; O60714; O60715; O60716; O60935; Q6DHZ7; Q6RBX8; Q9UP71; Q9UP72; Q9UP73"	"VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency"	"VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions"	"8"	"0"	"463.8"	"382.4"	"489.7"	"715.1"	"859.2"	"731.8"	"1851.1"	"1671.3"	"1168.5"	"1332.5"	"1378.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86UE4"	"Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2"	"18"	"7"	"14"	"7"	"582"	"63.8"	"9.32"	"2900.34"	"29.09"	"6"	"7"	"signal transduction;other biological processes"	"plasma membrane;other membranes;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf15686"	"92140"	"ENSG00000147649"	"MTDH"	"hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3"	"Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway"	""	"3"	"0"	"254.4"	"151.1"	"218.9"	"272.4"	"377.2"	"316.2"	"1113.7"	"1078.3"	"772.6"	"1096.6"	"1751.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25705"	"ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1"	"22"	"10"	"19"	"10"	"553"	"59.7"	"9.13"	"3053.40"	"29.00"	"8"	"9"	"other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;transporter activity;other molecular function"	"Pf00006, Pf00306, Pf02874"	"498"	"ENSG00000152234"	"ATP5F1A"	"A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8"	"Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation"	"Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling"	"6"	"0"	"420.4"	"349.7"	"397.0"	"588.8"	"723.1"	"642.8"	"1278.4"	"1383.2"	"880.7"	"1141.2"	"1290.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P47897"	"Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1"	"16"	"10"	"22"	"10"	"775"	"87.7"	"7.15"	"3761.30"	"28.91"	"9"	"9"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;mitochondrion;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00749, Pf03950, Pf04557, Pf04558"	"5859"	"ENSG00000172053"	"QARS1"	"B4DWJ2; hsa:5859; P47897"	""	"Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation"	"3"	"0"	"248.6"	"167.2"	"243.6"	"361.5"	"413.4"	"349.7"	"783.2"	"804.2"	"515.1"	"680.4"	"884.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23528"	"Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3"	"63"	"10"	"19"	"10"	"166"	"18.5"	"8.09"	"4454.40"	"28.83"	"10"	"8"	"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity"	"Pf00241"	"1072"	"ENSG00000172757"	"CFL1"	"B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2"	"Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway"	"Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Platelet degranulation ; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs"	"15"	"0"	"868.5"	"616.2"	"988.1"	"1130.9"	"1490.9"	"1606.8"	"2819.3"	"2402.2"	"1601.5"	"2651.5"	"5605.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99623"	"Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2"	"26"	"7"	"18"	"7"	"299"	"33.3"	"9.83"	"3432.50"	"28.82"	"7"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf01145"	"11331"	"ENSG00000215021"	"PHB2"	"B4DP75; hsa:11331; Q2YDA4; Q7KYU3; Q92978; Q99623"	""	"Processing of SMDT1"	"1"	"0"	"431.6"	"306.2"	"376.0"	"438.4"	"618.5"	"471.8"	"1041.1"	"956.0"	"556.1"	"814.0"	"972.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96EP5"	"DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1"	"20"	"7"	"15"	"7"	"407"	"43.4"	"8.56"	"3436.56"	"28.79"	"6"	"7"	"cell cycle OR cell proliferation;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"26528"	"ENSG00000071626"	"DAZAP1"	"hsa:26528; Q96EP5; Q96MJ3; Q9NRR9"	""	""	"0"	"0"	"326.0"	"254.9"	"347.2"	"531.8"	"591.1"	"537.5"	"1860.2"	"1797.7"	"1119.7"	"1289.2"	"1237.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3F4"	"Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1"	"31"	"7"	"14"	"7"	"350"	"38.4"	"5.12"	"2860.68"	"28.77"	"6"	"6"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf00400"	"11171"	"ENSG00000023734"	"STRAP"	"B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4"	"Epithelial to mesenchymal transition in colorectal cancer"	"Downregulation of TGF-beta receptor signaling"	"2"	"0"	"321.5"	"234.2"	"374.0"	"492.4"	"542.0"	"516.1"	"907.5"	"865.4"	"532.2"	"735.1"	"911.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P41091"	"Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3"	"18"	"7"	"14"	"7"	"472"	"51.1"	"8.40"	"2248.53"	"28.73"	"4"	"7"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00009, Pf03144, Pf09173"	"1968"	"ENSG00000130741"	"EIF2S3"	"A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency"	"12"	"0"	"377.2"	"212.4"	"318.4"	"446.6"	"596.8"	"529.3"	"1725.6"	"1623.0"	"1088.5"	"1634.8"	"2940.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBU9"	"Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1"	"18"	"7"	"13"	"7"	"619"	"70.1"	"8.51"	"2301.99"	"28.72"	"5"	"7"	"other metabolic processes;transport"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf02136, Pf03943, Pf09162"	"10482"	"ENSG00000162231"	"NXF1"	"B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2"	"mRNA processing"	"Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"5"	"0"	"106.1"	"84.1"	"119.4"	"141.2"	"185.6"	"146.9"	"704.9"	"715.7"	"517.1"	"645.1"	"711.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UQ13"	"Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2"	"16"	"7"	"15"	"7"	"582"	"64.8"	"8.46"	"2307.07"	"28.37"	"6"	"7"	"signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf13855"	"8036"	"ENSG00000108061"	"SHOC2"	"A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13"	"Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma"	"RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling"	"6"	"0"	"45.7"	"33.1"	"53.5"	"62.0"	"78.9"	"62.5"	"402.4"	"424.7"	"307.2"	"523.6"	"1009.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26373"	"60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4"	"32"	"8"	"16"	"8"	"211"	"24.2"	"11.65"	"2528.59"	"28.21"	"6"	"8"	"protein metabolism;other metabolic processes;developmental processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01294"	"6137"	"ENSG00000167526"	"RPL13"	"B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"581.5"	"388.7"	"553.9"	"658.4"	"872.9"	"717.2"	"3115.9"	"2757.7"	"1788.1"	"2221.1"	"2579.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13642"	"Four and a half LIM domains protein 1 OS=Homo sapiens OX=9606 GN=FHL1 PE=1 SV=4"	"25"	"7"	"12"	"7"	"323"	"36.2"	"8.97"	"1848.07"	"27.97"	"4"	"6"	"other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00412"	"2273"	"ENSG00000022267"	"FHL1"	"B7Z5T4; B7Z793; hsa:2273; O95212; Q13230; Q13642; Q13645; Q5JXI7; Q5M7Y6; Q6IB30; Q9NZ40; Q9UKZ8; Q9Y630"	"Notch signaling pathway"	""	"1"	"0"	"493.5"	"364.1"	"614.0"	"618.7"	"684.0"	"638.4"	"1633.6"	"1642.4"	"1080.1"	"1240.6"	"2084.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28370"	"Probable global transcription activator SNF2L1 OS=Homo sapiens OX=9606 GN=SMARCA1 PE=1 SV=2"	"8"	"10"	"19"	"5"	"1054"	"122.5"	"8.09"	"2841.31"	"27.92"	"8"	"9"	"cell organization and biogenesis;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00176, Pf00271, Pf09110, Pf09111"	"6594"	"ENSG00000102038"	"SMARCA1"	"hsa:6594; P28370; Q5JV41; Q5JV42"	"Nuclear receptors meta-pathway; Rett syndrome causing genes"	""	"2"	"0"	"142.9"	"103.1"	"162.6"	"191.0"	"252.3"	"206.2"	"759.5"	"681.2"	"496.6"	"664.3"	"860.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15293"	"Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1"	"20"	"6"	"13"	"6"	"331"	"38.9"	"5.00"	"2859.67"	"27.64"	"5"	"6"	"developmental processes"	"ER/Golgi"	"other molecular function"	"Pf13202"	"5954"	"ENSG00000049449"	"RCN1"	"B7Z1M1; D3DR00; hsa:5954; Q15293"	"VEGFA-VEGFR2 signaling"	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation"	"3"	"0"	"543.4"	"380.8"	"567.6"	"937.9"	"933.2"	"859.1"	"2945.9"	"2889.4"	"1641.3"	"2272.3"	"2800.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62280"	"40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3"	"45"	"9"	"20"	"9"	"158"	"18.4"	"10.30"	"3941.29"	"27.64"	"9"	"7"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00366, Pf16205"	"6205"	"ENSG00000142534"	"RPS11"	"B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0"	"VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins"	"Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"21"	"0"	"1134.5"	"675.5"	"1003.2"	"1188.1"	"1445.7"	"1271.3"	"4101.4"	"4075.3"	"2062.7"	"2669.1"	"3903.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60264"	"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1"	"11"	"12"	"21"	"7"	"1052"	"121.8"	"8.09"	"3428.62"	"27.61"	"11"	"10"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00176, Pf00271, Pf09110, Pf09111"	"8467"	"ENSG00000153147"	"SMARCA5"	"hsa:8467; O60264"	"10q11.21q11.23 copy number variation syndrome"	"Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression"	"5"	"5"	"491.3"	"310.5"	"456.7"	"623.7"	"803.1"	"667.2"	"2352.3"	"2159.1"	"1463.9"	"1831.3"	"2308.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78356"	"Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1"	"18"	"6"	"12"	"6"	"416"	"47.3"	"7.33"	"1644.33"	"27.56"	"4"	"6"	"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle"	"kinase activity;other molecular function"	"Pf01504"	"8396"	"ENSG00000276293; ENSG00000277292"	"PIP4K2B"	"hsa:8396; P78356; Q5U0E8; Q8TBP2"	"Regulation of actin cytoskeleton; 17q12 copy number variation syndrome"	"Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus"	"6"	"0"	"87.4"	"64.6"	"118.8"	"137.5"	"220.6"	"175.9"	"751.0"	"1160.2"	"1076.1"	"1956.8"	"2172.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y237"	"Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1"	"37"	"6"	"18"	"6"	"131"	"13.8"	"9.77"	"2767.02"	"27.51"	"4"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytoskeleton;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf13616"	"5303"	"ENSG00000102309"	"PIN4"	"A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237"	""	""	"0"	"0"	"249.8"	"160.2"	"238.6"	"306.6"	"430.3"	"357.9"	"3783.6"	"3962.2"	"2916.2"	"3075.7"	"4035.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01085"	"Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1"	"21"	"7"	"19"	"5"	"375"	"41.6"	"7.74"	"3360.24"	"27.29"	"7"	"6"	"cell cycle OR cell proliferation;stress response;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"7073"	"ENSG00000151923"	"TIAL1"	"A8K3T0; A8K4L9; hsa:7073; Q01085"	""	"FGFR2 alternative splicing"	"1"	"2"	"572.3"	"357.1"	"576.7"	"922.7"	"1038.9"	"843.2"	"2488.8"	"2389.4"	"1403.7"	"1595.8"	"1774.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15428"	"Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2"	"11"	"7"	"17"	"7"	"464"	"49.2"	"9.64"	"3566.01"	"27.27"	"7"	"6"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf12874, Pf16835"	"8175"	"ENSG00000104897"	"SF3A2"	"B2RBU1; D6W605; hsa:8175; O75245; Q15428"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"509.8"	"377.6"	"554.9"	"647.4"	"794.6"	"720.7"	"1843.4"	"1653.7"	"1215.2"	"1557.1"	"1766.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H4G4"	"Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens OX=9606 GN=GLIPR2 PE=1 SV=3"	"55"	"6"	"13"	"6"	"154"	"17.2"	"9.41"	"2728.82"	"27.20"	"5"	"6"	"other biological processes"	"non-structural extracellular;other membranes;ER/Golgi"	"other molecular function"	"Pf00188"	"152007"	"ENSG00000122694"	"GLIPR2"	"hsa:152007; Q5VZR1; Q8N2S6; Q8WWC9; Q8WX36; Q9H4G4"	""	""	"0"	"0"	"134.0"	"103.5"	"139.3"	"172.7"	"238.7"	"212.4"	"1086.9"	"1112.2"	"1168.8"	"1768.6"	"2083.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13151"	"Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1"	"21"	"7"	"22"	"5"	"305"	"30.8"	"9.29"	"4201.41"	"27.05"	"5"	"6"	"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"10949"	"ENSG00000177733"	"HNRNPA0"	"hsa:10949; Q13151; Q6IB18"	""	""	"0"	"0"	"513.2"	"291.3"	"428.5"	"542.7"	"670.1"	"566.0"	"1860.3"	"1544.1"	"967.2"	"1204.5"	"1677.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H9Y6"	"DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2"	"8"	"7"	"16"	"7"	"1135"	"128.1"	"7.83"	"3146.69"	"26.88"	"7"	"7"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883"	"84172"	"ENSG00000125630"	"POLR1B"	"B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6"	"Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination"	"8"	"0"	"154.5"	"99.0"	"152.3"	"226.0"	"270.1"	"236.5"	"541.2"	"1072.4"	"1091.5"	"1777.7"	"2273.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96AG4"	"Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1"	"20"	"5"	"12"	"5"	"307"	"34.9"	"9.57"	"1843.42"	"26.78"	"4"	"5"	""	"other membranes;mitochondrion;ER/Golgi;nucleus;other cell component"	""	"Pf13855"	"55379"	"ENSG00000108829"	"LRRC59"	"B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"303.4"	"213.7"	"287.0"	"330.0"	"461.2"	"383.2"	"1693.5"	"1708.5"	"1352.6"	"2147.1"	"2669.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14625"	"Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1"	"17"	"11"	"17"	"11"	"803"	"92.4"	"4.84"	"2688.07"	"26.73"	"8"	"9"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf00183, Pf02518"	"7184"	"ENSG00000166598"	"HSP90B1"	"hsa:7184; P14625; Q96A97"	"Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes"	"11"	"0"	"642.6"	"430.7"	"655.8"	"1076.7"	"1330.6"	"1157.0"	"2172.0"	"1992.0"	"1085.4"	"1591.3"	"2149.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43660"	"Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1"	"10"	"6"	"17"	"6"	"514"	"57.2"	"9.17"	"2661.66"	"26.67"	"6"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other membranes;nucleus;other cell component"	""	"Pf00400"	"5356"	"ENSG00000171566"	"PLRG1"	"B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"383.4"	"232.7"	"320.3"	"410.5"	"555.0"	"450.1"	"3645.0"	"3455.9"	"1796.0"	"2357.3"	"3246.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18621"	"60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3"	"33"	"6"	"17"	"6"	"184"	"21.4"	"10.17"	"2151.60"	"26.56"	"5"	"6"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf00237"	"6139"	"ENSG00000265681"	"RPL17"	"B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5"	"Cytoplasmic ribosomal proteins"	"SRP-dependent cotranslational protein targeting to membrane; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"548.8"	"343.6"	"493.9"	"628.1"	"822.0"	"632.3"	"3389.6"	"3025.7"	"1741.6"	"2234.7"	"2491.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43172"	"U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2"	"21"	"9"	"16"	"9"	"522"	"58.4"	"7.42"	"2852.85"	"26.54"	"8"	"8"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf00400, Pf08799"	"9128"	"ENSG00000136875"	"PRPF4"	"hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"244.6"	"146.7"	"199.7"	"268.2"	"338.7"	"285.9"	"768.2"	"763.0"	"514.0"	"699.1"	"951.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06576"	"ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3"	"12"	"5"	"16"	"5"	"529"	"56.5"	"5.40"	"3130.73"	"26.47"	"5"	"5"	"other metabolic processes;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;mitochondrion;other cell component"	"signal transduction activity or receptor binding;transporter activity;other molecular function"	"Pf00006, Pf02874"	"506"	"ENSG00000110955"	"ATP5F1B"	"A8K4X0; hsa:506; P06576; Q14283"	"Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation"	"Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling"	"7"	"0"	"218.2"	"153.7"	"203.7"	"261.6"	"324.0"	"306.7"	"602.4"	"642.1"	"386.8"	"532.7"	"708.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15042"	"U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2"	"9"	"9"	"15"	"8"	"1029"	"118.2"	"8.47"	"2565.53"	"26.44"	"7"	"8"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf00076, Pf01805, Pf04818, Pf08312"	"23350"	"ENSG00000163714"	"U2SURP"	"A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"639.1"	"331.9"	"590.1"	"719.5"	"933.9"	"787.3"	"1977.2"	"1708.1"	"837.8"	"1194.4"	"1648.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q4VCS5"	"Angiomotin OS=Homo sapiens OX=9606 GN=AMOT PE=1 SV=1"	"7"	"7"	"14"	"5"	"1084"	"118.0"	"7.64"	"1745.51"	"26.28"	"5"	"7"	"cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf12240"	"154796"	"ENSG00000126016"	"AMOT"	"hsa:154796; Q4VCS5; Q504X5; Q9HD27; Q9UPT1"	"VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Pleural mesothelioma"	""	"3"	"1"	"225.2"	"160.8"	"196.2"	"240.4"	"362.6"	"314.1"	"791.1"	"669.8"	"452.3"	"592.2"	"762.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N1F7"	"Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2"	"11"	"9"	"19"	"9"	"819"	"93.4"	"5.72"	"3344.98"	"26.27"	"9"	"8"	"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus"	"other molecular function"	"Pf04097"	"9688"	"ENSG00000102900"	"NUP93"	"B3KPQ8; hsa:9688; Q14705; Q8N1F7"	""	"SUMOylation of DNA replication proteins; Regulation of HSF1-mediated heat shock response; HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation"	"29"	"0"	"405.9"	"317.2"	"433.0"	"681.8"	"791.8"	"636.9"	"1171.7"	"1160.6"	"664.6"	"980.9"	"1048.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94906"	"Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1"	"10"	"9"	"18"	"9"	"941"	"106.9"	"8.25"	"2791.81"	"26.22"	"8"	"8"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf06424, Pf13181"	"24148"	"ENSG00000101161"	"PRPF6"	"B2RAR5; B3KMC6; hsa:24148; O94906; O95109; Q5VXS5; Q9H3Z1; Q9H4T9; Q9H4U8; Q9NTE6"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"374.1"	"261.6"	"373.0"	"450.1"	"566.9"	"502.2"	"1397.4"	"1210.3"	"829.7"	"1112.4"	"1332.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P80723"	"Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2"	"37"	"7"	"15"	"7"	"227"	"22.7"	"4.63"	"4036.42"	"26.06"	"6"	"5"	"developmental processes;other biological processes"	"plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf05466"	"10409"	"ENSG00000176788"	"BASP1"	"B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5"	""	"RHOF GTPase cycle"	"1"	"0"	"700.8"	"300.6"	"605.3"	"545.1"	"640.3"	"598.1"	"1426.1"	"1366.7"	"794.7"	"1092.1"	"2169.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13243"	"Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1"	"23"	"7"	"12"	"6"	"272"	"31.2"	"11.59"	"1297.36"	"25.93"	"4"	"7"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf00076"	"6430"	"ENSG00000100650"	"SRSF5"	"hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0"	"mRNA processing"	"mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"6"	"0"	"282.0"	"150.3"	"279.8"	"327.1"	"423.2"	"325.7"	"1092.5"	"1035.4"	"605.5"	"858.2"	"930.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14854"	"Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2"	"63"	"6"	"12"	"6"	"86"	"10.2"	"7.05"	"1755.54"	"25.92"	"4"	"6"	"other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity"	"Pf02297"	"1340"	"ENSG00000126267"	"COX6B1"	"B2R5C9; hsa:1340; P14854; Q6IBL4"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation"	"Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1"	"7"	"0"	"531.7"	"332.8"	"452.3"	"691.3"	"886.7"	"820.9"	"1214.1"	"1240.9"	"996.2"	"1074.6"	"1534.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZT1"	"Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2"	"53"	"5"	"13"	"5"	"146"	"15.9"	"4.44"	"2388.90"	"25.92"	"4"	"5"	"signal transduction;other biological processes"	"non-structural extracellular;other cell component"	"enzyme regulator activity;other molecular function"	"Pf13499"	"51806"	"ENSG00000178372"	"CALML5"	"hsa:51806; Q5SQI3; Q8IXU8; Q9NZT1"	"Alzheimer's disease and miRNA effects; Ras signaling; Melanoma; Alzheimer's disease"	"Neutrophil degranulation"	"5"	"0"	"99.8"	"61.8"	"90.9"	"119.3"	"156.7"	"160.3"	"886.8"	"903.0"	"643.9"	"780.5"	"649.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30419"	"Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2"	"14"	"5"	"12"	"5"	"496"	"56.8"	"7.80"	"2474.26"	"25.89"	"5"	"5"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf01233, Pf02799"	"4836"	"ENSG00000136448"	"NMT1"	"A8K7C1; hsa:4836; P30419; Q9UE09"	""	"Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria"	"3"	"0"	"68.7"	"42.1"	"72.6"	"100.6"	"127.1"	"98.8"	"391.3"	"417.7"	"322.4"	"549.5"	"995.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75475"	"PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1"	"18"	"7"	"12"	"7"	"530"	"60.1"	"9.13"	"2318.21"	"25.88"	"5"	"7"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00855, Pf11467"	"11168"	"ENSG00000164985"	"PSIP1"	"D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6"	"MECP2 and associated Rett syndrome"	"Formation of WDR5-containing histone-modifying complexes; Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection"	"8"	"0"	"262.0"	"138.3"	"233.6"	"284.7"	"368.0"	"304.6"	"1632.9"	"1683.9"	"984.5"	"1486.4"	"2455.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15185"	"Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1"	"38"	"5"	"15"	"5"	"160"	"18.7"	"4.54"	"3080.58"	"25.86"	"5"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf04969"	"10728"	"ENSG00000110958"	"PTGES3"	"A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70"	"Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway"	"Estrogen-dependent gene expression; Potential therapeutics for SARS; HSF1 activation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Attenuation phase"	"11"	"0"	"859.6"	"507.6"	"797.0"	"954.8"	"1095.4"	"1112.4"	"2651.2"	"2577.6"	"1466.3"	"1640.1"	"1873.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55084"	"Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3"	"19"	"10"	"19"	"10"	"474"	"51.3"	"9.41"	"3611.13"	"25.83"	"10"	"9"	"other metabolic processes;other biological processes"	"other membranes;mitochondrion;ER/Golgi"	"nucleic acid binding activity;other molecular function"	"Pf00108, Pf02803"	"3032"	"ENSG00000138029"	"HADHB"	"B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8"	"Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA"	"12"	"0"	"582.0"	"369.7"	"539.7"	"660.2"	"888.3"	"745.3"	"1955.0"	"1866.4"	"1145.6"	"1693.5"	"2040.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50991"	"T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4"	"19"	"7"	"15"	"7"	"539"	"57.9"	"7.83"	"2545.15"	"25.73"	"6"	"6"	"protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00118"	"10575"	"ENSG00000115484"	"CCT4"	"B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51"	"16p11.2 proximal deletion syndrome"	"Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; Folding of actin by CCT/TriC"	"7"	"0"	"335.9"	"293.8"	"385.6"	"544.0"	"582.9"	"573.4"	"819.1"	"797.2"	"551.1"	"756.3"	"870.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75934"	"Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1"	"26"	"5"	"12"	"5"	"225"	"26.1"	"5.66"	"2908.93"	"25.69"	"5"	"5"	"RNA metabolism OR transcription;other metabolic processes"	"cytoskeleton;nucleus;other cell component"	""	"Pf05700"	"10286"	"ENSG00000116752"	"BCAS2"	"hsa:10286; O75934; Q6FGS0"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"185.9"	"122.9"	"160.6"	"211.7"	"305.5"	"263.6"	"800.2"	"806.4"	"559.8"	"810.0"	"1275.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78371"	"T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4"	"27"	"13"	"22"	"13"	"535"	"57.5"	"6.46"	"4935.87"	"25.66"	"13"	"8"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00118"	"10576"	"ENSG00000166226"	"CCT2"	"A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3"	"16p11.2 proximal deletion syndrome"	"Neutrophil degranulation; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC; BBSome-mediated cargo-targeting to cilium; RHOBTB1 GTPase cycle"	"10"	"0"	"612.1"	"490.5"	"649.7"	"845.6"	"991.2"	"902.3"	"1425.7"	"1361.2"	"949.9"	"1244.5"	"1600.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46109"	"Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1"	"33"	"7"	"13"	"7"	"303"	"33.8"	"6.74"	"2186.42"	"25.59"	"6"	"7"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00017, Pf00018, Pf07653"	"1399"	"ENSG00000099942"	"CRKL"	"A8KA44; D3DX35; hsa:1399; P46109"	"Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; A network map of Macrophage-stimulating protein (MSP) signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway"	"Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling"	"21"	"0"	"462.4"	"314.8"	"483.9"	"523.3"	"552.3"	"584.9"	"864.4"	"878.7"	"570.0"	"772.0"	"974.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UHB6"	"LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1"	"10"	"8"	"16"	"8"	"759"	"85.2"	"6.84"	"2452.31"	"25.49"	"6"	"8"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00412"	"51474"	"ENSG00000050405"	"LIMA1"	"B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6"	""	""	"0"	"0"	"428.2"	"259.5"	"405.6"	"645.4"	"784.9"	"673.9"	"1834.7"	"1708.1"	"1058.3"	"1391.0"	"1698.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q00341"	"Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=2"	"8"	"8"	"16"	"8"	"1268"	"141.4"	"6.87"	"2727.16"	"25.46"	"8"	"8"	"other metabolic processes;transport"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013"	"3069"	"ENSG00000115677"	"HDLBP"	"B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3"	"2q37 copy number variation syndrome"	"HDL clearance"	"2"	"0"	"104.3"	"64.3"	"92.4"	"116.6"	"163.7"	"124.8"	"475.4"	"438.4"	"291.0"	"367.4"	"463.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35268"	"60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2"	"61"	"6"	"11"	"6"	"128"	"14.8"	"9.19"	"1412.93"	"25.42"	"4"	"6"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01776"	"6146"	"ENSG00000116251"	"RPL22"	"B2R495; hsa:6146; P35268; Q6IBD1"	"Cytoplasmic ribosomal proteins"	"SRP-dependent cotranslational protein targeting to membrane; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"93.6"	"56.9"	"82.5"	"121.4"	"161.9"	"126.4"	"803.9"	"824.4"	"565.5"	"779.4"	"1009.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05387"	"60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1"	"46"	"5"	"14"	"4"	"115"	"11.7"	"4.54"	"2881.01"	"25.38"	"5"	"4"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf00428"	"6181"	"ENSG00000177600"	"RPLP2"	"hsa:6181; P05387; Q6FG96"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"16"	"0"	"269.1"	"143.0"	"216.1"	"326.8"	"391.0"	"352.5"	"1546.2"	"1365.0"	"857.1"	"1219.2"	"1379.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BUJ2"	"Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2"	"11"	"10"	"18"	"9"	"856"	"95.7"	"6.92"	"3261.16"	"25.25"	"8"	"8"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00622, Pf02037, Pf13671"	"11100"	"ENSG00000105323"	"HNRNPUL1"	"B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75"	""	""	"0"	"0"	"591.8"	"344.9"	"551.9"	"689.7"	"862.6"	"728.2"	"1740.9"	"1660.4"	"926.4"	"1243.0"	"1820.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23588"	"Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2"	"12"	"9"	"15"	"9"	"611"	"69.1"	"5.73"	"3002.95"	"25.21"	"7"	"7"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus"	"nucleic acid binding activity"	"Pf00076"	"1975"	"ENSG00000063046"	"EIF4B"	"B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5"	"Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; mTORC1-mediated signalling"	"14"	"0"	"627.3"	"354.6"	"558.0"	"720.4"	"898.9"	"832.0"	"1903.5"	"2024.2"	"1080.5"	"1469.6"	"2215.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06733"	"Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2"	"21"	"8"	"15"	"8"	"434"	"47.1"	"7.39"	"2848.73"	"25.07"	"7"	"7"	"other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00113, Pf03952"	"2023"	"ENSG00000074800"	"ENO1"	"B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55"	"Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism"	"9"	"0"	"960.1"	"701.5"	"1018.3"	"1273.2"	"1551.7"	"1770.5"	"2567.3"	"2180.3"	"1323.7"	"2213.4"	"4664.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46782"	"40S ribosomal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4"	"23"	"6"	"13"	"6"	"204"	"22.9"	"9.72"	"2278.78"	"24.97"	"6"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00177"	"6193"	"ENSG00000083845"	"RPS5"	"B2R4T2; hsa:6193; P46782; Q96BN0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"397.3"	"285.1"	"353.1"	"414.8"	"497.2"	"441.2"	"1517.2"	"1383.8"	"1050.9"	"1078.4"	"1421.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3A5"	"Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4"	"40"	"8"	"12"	"8"	"250"	"28.7"	"8.75"	"2206.38"	"24.97"	"5"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;translation activity;nucleic acid binding activity"	"Pf01172, Pf09377, Pf20268"	"51119"	"ENSG00000126524"	"SBDS"	"A8K0P4; hsa:51119; Q96FX0; Q9NV53; Q9Y3A5"	"Genetic causes of porto-sinusoidal vascular disease"	""	"1"	"0"	"154.7"	"104.8"	"148.3"	"202.6"	"260.5"	"195.7"	"1580.2"	"1751.6"	"1212.5"	"2465.7"	"6230.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78347"	"General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2"	"9"	"8"	"15"	"8"	"998"	"112.3"	"6.39"	"2886.08"	"24.94"	"5"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02946"	"2969"	"ENSG00000263001"	"GTF2I"	"hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4"	"B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease"	""	"3"	"0"	"355.7"	"267.5"	"344.9"	"538.4"	"614.4"	"542.6"	"1772.9"	"1617.9"	"1149.5"	"1429.5"	"1847.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A0FGR8"	"Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1"	"8"	"6"	"12"	"6"	"921"	"102.3"	"9.26"	"1776.97"	"24.83"	"4"	"6"	"cell organization and biogenesis;transport"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf00168, Pf17047"	"57488"	"ENSG00000117868"	"ESYT2"	"A0FGR8; A4D229; hsa:57488; Q69YJ2; Q6UKI4; Q6ZTU0; Q6ZVU1; Q9BQS0; Q9NW47; Q9ULJ2"	""	"Glycosphingolipid metabolism"	"1"	"0"	"123.6"	"78.5"	"126.6"	"199.5"	"203.3"	"203.1"	"580.5"	"950.3"	"1026.2"	"1789.1"	"2313.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35580"	"Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3"	"4"	"8"	"15"	"5"	"1976"	"228.9"	"5.54"	"2741.24"	"24.70"	"7"	"8"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00063, Pf00612, Pf01576, Pf02736"	"4628"	"ENSG00000133026"	"MYH10"	"B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0"	"Regulation of actin cytoskeleton"	"EPHA-mediated growth cone collapse; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs"	"7"	"0"	"127.4"	"87.6"	"135.9"	"160.9"	"226.0"	"189.1"	"535.3"	"490.2"	"257.6"	"405.4"	"578.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01081"	"Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3"	"30"	"5"	"12"	"5"	"240"	"27.9"	"8.81"	"2161.49"	"24.64"	"3"	"5"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf00642"	"102724594; 7307"	"ENSG00000160201"	"U2AF1"	"hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"5"	"0"	"194.0"	"147.8"	"217.3"	"288.9"	"358.3"	"345.5"	"1397.3"	"1327.0"	"558.1"	"757.1"	"883.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92738"	"USP6 N-terminal-like protein OS=Homo sapiens OX=9606 GN=USP6NL PE=1 SV=3"	"15"	"9"	"16"	"9"	"828"	"94.0"	"9.07"	"3521.97"	"24.62"	"8"	"7"	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00566"	"9712"	"ENSG00000148429"	"USP6NL"	"A8KA79; hsa:9712; Q15400; Q5VV10; Q7L0K9; Q92738"	"EGF/EGFR signaling pathway"	"Retrograde transport at the Trans-Golgi-Network"	"2"	"0"	"72.6"	"54.2"	"84.6"	"89.7"	"136.3"	"136.7"	"1080.4"	"2178.0"	"2243.8"	"2780.4"	"2946.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13868"	"Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2"	"27"	"6"	"15"	"6"	"293"	"32.8"	"7.50"	"3106.97"	"24.59"	"6"	"5"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf14382, Pf15985"	"23404"	"ENSG00000130713"	"EXOSC2"	"A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4"	"Ciliary landscape"	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"7"	"0"	"241.9"	"162.5"	"229.2"	"331.6"	"416.5"	"366.2"	"896.1"	"866.0"	"561.1"	"754.4"	"1028.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P16989"	"Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4"	"28"	"7"	"13"	"4"	"372"	"40.1"	"9.77"	"2200.40"	"24.56"	"6"	"6"	"stress response;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00313"	"8531"	"ENSG00000060138"	"YBX3"	"B2RBW6; hsa:8531; P16989; Q14121; Q969N6; Q96B76"	"RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer"	""	"2"	"0"	"67.6"	"45.5"	"67.3"	"93.2"	"111.7"	"97.8"	"205.9"	"223.6"	"125.1"	"180.7"	"226.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P83731"	"60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1"	"36"	"6"	"16"	"6"	"157"	"17.8"	"11.25"	"3271.26"	"24.55"	"6"	"5"	"protein metabolism;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01246"	"6152"	"ENSG00000114391"	"RPL24"	"B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"409.1"	"263.4"	"392.0"	"450.8"	"636.9"	"521.9"	"2287.7"	"2107.8"	"1278.5"	"1685.2"	"1878.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q07157"	"Tight junction protein ZO-1 OS=Homo sapiens OX=9606 GN=TJP1 PE=1 SV=3"	"5"	"7"	"14"	"7"	"1748"	"195.3"	"6.70"	"2866.82"	"24.54"	"7"	"7"	"cell adhesion;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00595, Pf00625, Pf00791, Pf07653"	"7082"	"ENSG00000104067; ENSG00000277401"	"TJP1"	"B4E3K1; hsa:7082; Q07157; Q2NKP3; Q4ZGJ6"	"Epithelial to mesenchymal transition in colorectal cancer; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Disruption of postsynaptic signaling by CNV; 1q21.1 copy number variation syndrome; CKAP4 signaling pathway map; 15q11q13 copy number variation"	"RUNX1 regulates expression of components of tight junctions; Signaling by Hippo; Regulation of gap junction activity; SARS-CoV-2 targets PDZ proteins in cell-cell junction; Apoptotic cleavage of cell adhesion  proteins"	"12"	"0"	"241.5"	"184.5"	"225.5"	"312.8"	"410.3"	"337.0"	"961.1"	"940.4"	"626.3"	"822.7"	"1024.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50502"	"Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2"	"21"	"7"	"14"	"7"	"369"	"41.3"	"5.27"	"2609.54"	"24.50"	"7"	"7"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf17830, Pf18253"	"6767"	"ENSG00000100380"	"ST13"	"hsa:6767; O14999; P50502; Q2TU77"	""	"Regulation of HSF1-mediated heat shock response"	"1"	"0"	"486.2"	"343.0"	"494.2"	"925.5"	"1083.1"	"962.1"	"1239.6"	"1160.5"	"842.8"	"1133.6"	"1443.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q2TAY7"	"WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2"	"12"	"6"	"15"	"6"	"513"	"57.5"	"7.18"	"2629.79"	"24.48"	"6"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf00400, Pf17814"	"55234"	"ENSG00000122692"	"SMU1"	"B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"155.8"	"117.2"	"160.5"	"220.3"	"283.8"	"238.7"	"1216.7"	"1144.8"	"822.9"	"1142.6"	"1228.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62851"	"40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1"	"38"	"6"	"18"	"6"	"125"	"13.7"	"10.11"	"2759.60"	"24.39"	"6"	"6"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf03297"	"6230"	"ENSG00000118181; ENSG00000280831"	"RPS25"	"B2R4M7; hsa:6230; P25111; P62851"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"565.3"	"402.7"	"502.8"	"585.5"	"680.8"	"632.4"	"2096.7"	"1932.0"	"1402.9"	"1533.7"	"2027.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07737"	"Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2"	"47"	"6"	"14"	"6"	"140"	"15.0"	"8.27"	"2302.94"	"24.37"	"4"	"6"	"cell organization and biogenesis;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00235"	"5216"	"ENSG00000108518"	"PFN1"	"hsa:5216; P07737; Q53Y44"	"Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway"	"RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors"	"9"	"0"	"318.4"	"241.7"	"315.8"	"377.2"	"502.6"	"529.9"	"977.6"	"882.2"	"486.4"	"754.2"	"1491.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9ULV4"	"Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1"	"20"	"11"	"21"	"11"	"474"	"53.2"	"7.08"	"4150.18"	"24.33"	"10"	"7"	"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00400, Pf08953, Pf16300"	"23603"	"ENSG00000110880"	"CORO1C"	"A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4"	""	""	"0"	"0"	"617.1"	"337.9"	"562.1"	"691.4"	"914.4"	"806.8"	"3934.2"	"3649.3"	"2358.0"	"3047.3"	"3730.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P43487"	"Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1"	"28"	"5"	"12"	"5"	"201"	"23.3"	"5.29"	"1858.61"	"24.31"	"4"	"5"	"transport;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00638"	"5902"	"ENSG00000099901"	"RANBP1"	"hsa:5902; P43487; Q53EY3"	"22q11.2 copy number variation syndrome"	"Rev-mediated nuclear export of HIV RNA"	"2"	"0"	"373.6"	"153.5"	"374.2"	"541.2"	"661.5"	"542.5"	"1314.6"	"1217.2"	"574.3"	"860.6"	"1597.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14126"	"Desmoglein-2 OS=Homo sapiens OX=9606 GN=DSG2 PE=1 SV=2"	"9"	"7"	"12"	"7"	"1118"	"122.2"	"5.24"	"1766.32"	"24.30"	"5"	"7"	"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;other cell component"	"other molecular function"	"Pf00028"	"1829"	"ENSG00000046604"	"DSG2"	"hsa:1829; Q14126; Q4KKU6"	"Arrhythmogenic right ventricular cardiomyopathy; GDNF signaling"	"Formation of the cornified envelope; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Apoptotic cleavage of cell adhesion  proteins"	"8"	"0"	"318.3"	"215.1"	"294.1"	"385.7"	"476.4"	"418.0"	"742.8"	"668.5"	"377.0"	"576.3"	"754.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49756"	"RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3"	"9"	"7"	"14"	"7"	"843"	"100.1"	"6.32"	"2650.50"	"24.25"	"6"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf01480"	"58517"	"ENSG00000119707"	"RBM25"	"A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"590.5"	"280.0"	"431.3"	"589.7"	"818.9"	"659.1"	"2336.4"	"1963.2"	"1061.0"	"1890.0"	"2635.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6UX04"	"Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1"	"6"	"3"	"11"	"3"	"472"	"53.8"	"5.80"	"2575.40"	"24.07"	"3"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf00160"	"10283"	"ENSG00000153015"	"CWC27"	"hsa:10283; O60529; O60530; Q6UX04; Q96EM3"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"105.9"	"75.1"	"101.6"	"128.1"	"170.1"	"146.9"	"435.6"	"468.4"	"291.3"	"393.0"	"448.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IX12"	"Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2"	"7"	"7"	"14"	"7"	"1150"	"132.7"	"5.76"	"2535.41"	"24.05"	"7"	"7"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02037, Pf14443, Pf14444, Pf19256, Pf19257"	"55749"	"ENSG00000060339"	"CCAR1"	"A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"426.6"	"249.2"	"370.9"	"558.2"	"732.8"	"549.2"	"1599.5"	"1547.0"	"846.7"	"1260.7"	"1697.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P54886"	"Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2"	"13"	"9"	"17"	"9"	"795"	"87.2"	"7.12"	"2765.48"	"24.05"	"9"	"8"	"other metabolic processes"	"other membranes;mitochondrion"	"kinase activity;other molecular function"	"Pf00171, Pf00696"	"5832"	"ENSG00000059573"	"ALDH18A1"	"B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72"	"Amino acid metabolism"	""	"1"	"0"	"241.0"	"205.4"	"284.8"	"470.1"	"518.1"	"418.4"	"1080.0"	"996.8"	"650.8"	"798.7"	"896.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P67775"	"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1"	"30"	"6"	"10"	"6"	"309"	"35.6"	"5.54"	"1350.73"	"24.05"	"4"	"6"	"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00149"	"5515"	"ENSG00000113575"	"PPP2CA"	"hsa:5515; P05323; P13197; P67775"	"Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome"	"RAF activation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated"	"52"	"0"	"263.8"	"202.3"	"292.9"	"440.7"	"501.3"	"452.1"	"983.2"	"961.9"	"653.4"	"915.3"	"1169.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07197"	"Neurofilament medium polypeptide OS=Homo sapiens OX=9606 GN=NEFM PE=1 SV=3"	"11"	"11"	"20"	"9"	"916"	"102.4"	"4.91"	"3220.44"	"24.04"	"11"	"9"	"cell organization and biogenesis"	"cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf00038, Pf04732"	"4741"	"ENSG00000104722"	"NEFM"	"B4DGN2; E9PBF7; hsa:4741; P07197; Q4QRK6"	"Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways; Ciliary landscape"	""	"3"	"1"	"845.7"	"586.5"	"797.9"	"1220.7"	"1505.7"	"1216.7"	"1878.4"	"1596.3"	"1002.7"	"1472.0"	"1922.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96ST2"	"Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2"	"13"	"10"	"17"	"10"	"819"	"91.9"	"4.69"	"3347.49"	"24.04"	"8"	"8"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus"	""	"Pf08711"	"55677"	"ENSG00000163166"	"IWS1"	"hsa:55677; Q2TB65; Q6P157; Q8N3E8; Q96MI7; Q96ST2; Q9NV97; Q9NWH8"	""	"RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex"	"3"	"0"	"584.4"	"407.0"	"626.9"	"850.7"	"973.5"	"979.4"	"2443.8"	"2418.1"	"1533.9"	"1961.4"	"2508.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07355"	"Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2"	"24"	"8"	"14"	"8"	"339"	"38.6"	"7.75"	"2067.25"	"23.95"	"6"	"8"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00191"	"302"	"ENSG00000182718"	"ANXA2"	"hsa:302; P07355; Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8"	"Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation"	"Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Dissolution of Fibrin Clot"	"7"	"0"	"198.8"	"122.2"	"197.0"	"232.7"	"310.5"	"278.7"	"1531.9"	"1622.5"	"913.0"	"1412.9"	"2298.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P53582"	"Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2"	"26"	"7"	"10"	"7"	"386"	"43.2"	"7.17"	"1115.38"	"23.93"	"3"	"7"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00557, Pf15801"	"23173"	"ENSG00000164024"	"METAP1"	"B4E2E6; hsa:23173; P53582"	""	"Inactivation, recovery and regulation of the phototransduction cascade"	"1"	"0"	"184.1"	"143.9"	"226.4"	"280.0"	"333.1"	"323.9"	"878.5"	"960.2"	"747.0"	"1088.0"	"1551.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35579"	"Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4"	"5"	"10"	"18"	"7"	"1960"	"226.4"	"5.60"	"2820.22"	"23.89"	"9"	"9"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00063, Pf01576, Pf02736"	"4627"	"ENSG00000100345"	"MYH9"	"A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83"	"Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response"	"16"	"3"	"255.9"	"174.2"	"263.3"	"357.7"	"449.8"	"405.6"	"1045.9"	"938.7"	"549.6"	"798.9"	"1159.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51659"	"Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3"	"16"	"7"	"12"	"7"	"736"	"79.6"	"8.84"	"1738.12"	"23.85"	"4"	"6"	"other metabolic processes;developmental processes"	"cytosol;other cytoplasmic organelle"	"other molecular function"	"Pf00106, Pf01575, Pf02036"	"3295"	"ENSG00000133835"	"HSD17B4"	"B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659"	"Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency"	"TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids"	"10"	"0"	"136.8"	"109.0"	"140.6"	"182.8"	"216.1"	"181.5"	"506.7"	"503.7"	"336.5"	"439.7"	"590.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P48739"	"Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2"	"28"	"6"	"10"	"6"	"271"	"31.5"	"6.87"	"1026.88"	"23.80"	"3"	"6"	"cell organization and biogenesis;other metabolic processes;transport"	"other membranes;ER/Golgi;other cell component"	"transporter activity;other molecular function"	"Pf02121"	"23760"	"ENSG00000180957"	"PITPNB"	"B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1"	""	"PI and PC transport between ER and Golgi membranes"	"1"	"0"	"196.5"	"146.6"	"186.7"	"308.6"	"404.7"	"352.2"	"493.5"	"596.3"	"430.4"	"490.8"	"656.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BY44"	"Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3"	"12"	"6"	"14"	"6"	"585"	"64.9"	"8.87"	"2613.43"	"23.77"	"6"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;translational apparatus;other cell component"	"translation activity;nucleic acid binding activity"	"Pf08662"	"83939"	"ENSG00000144895"	"EIF2A"	"A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44"	"Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome"	""	"3"	"0"	"207.2"	"125.5"	"208.7"	"251.9"	"320.7"	"304.0"	"1079.0"	"1019.5"	"795.9"	"1065.2"	"1794.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15637"	"Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4"	"11"	"5"	"12"	"5"	"639"	"68.3"	"8.98"	"1809.39"	"23.65"	"4"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"translational apparatus;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf00098, Pf16275"	"7536"	"ENSG00000168066"	"SF1"	"B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"241.6"	"136.7"	"260.0"	"336.4"	"413.1"	"356.4"	"928.1"	"854.5"	"500.7"	"666.0"	"871.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60174"	"Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=3"	"23"	"7"	"14"	"7"	"286"	"30.8"	"5.92"	"2555.39"	"23.57"	"7"	"7"	"other metabolic processes"	"cytosol"	"other molecular function"	"Pf00121"	""	"ENSPPYG00000004207; ENSPTRG00000004595"	"TPI1"	"A0A2J8JEI5; A0A2J8JEJ3; A0A2J8TBG7; A0A6D2X563; H2NGA4"	""	""	"0"	"0"	"646.1"	"522.0"	"713.2"	"746.4"	"941.5"	"1122.9"	"1644.0"	"1360.0"	"734.4"	"1383.3"	"3205.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14776"	"Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2"	"7"	"7"	"15"	"7"	"1098"	"123.8"	"8.65"	"2465.35"	"23.49"	"7"	"7"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf00397, Pf01846"	"10915"	"ENSG00000113649"	"TCERG1"	"hsa:10915; O14776; Q2NKN2; Q59EA1"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"320.4"	"227.4"	"293.7"	"375.7"	"492.4"	"401.5"	"1387.9"	"1281.3"	"927.4"	"1235.6"	"1772.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92688"	"Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1"	"25"	"6"	"12"	"4"	"251"	"28.8"	"4.06"	"1727.05"	"23.47"	"5"	"5"	"cell organization and biogenesis;developmental processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf12799"	"10541"	"ENSG00000136938"	"ANP32B"	"B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688"	""	""	"0"	"0"	"162.8"	"87.2"	"150.7"	"195.2"	"278.6"	"198.1"	"1132.7"	"1159.4"	"686.8"	"768.5"	"962.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WYA6"	"Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1"	"12"	"8"	"16"	"8"	"563"	"65.1"	"5.05"	"2797.62"	"23.46"	"7"	"8"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf08216"	"56259"	"ENSG00000132792"	"CTNNBL1"	"B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"458.5"	"283.5"	"424.4"	"560.8"	"722.3"	"631.4"	"3027.4"	"3023.7"	"1809.2"	"2259.4"	"2922.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12532"	"Creatine kinase U-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT1A PE=1 SV=1"	"13"	"4"	"11"	"4"	"417"	"47.0"	"8.34"	"1887.62"	"23.43"	"3"	"4"	"other metabolic processes"	"other membranes;mitochondrion"	"kinase activity;other molecular function"	"Pf00217, Pf02807"	"1159; 548596"	"ENSG00000223572; ENSG00000237289"	"CKMT1A; CKMT1B"	"B4DIT8; B7ZA09; hsa:1159; hsa:548596; P12532; Q0VAM3; Q32NF6; Q53FC4"	""	"Creatine metabolism"	"1"	"0"	"150.6"	"92.0"	"142.5"	"187.3"	"227.0"	"161.3"	"1006.0"	"1080.6"	"797.0"	"814.7"	"1134.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P16104"	"Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2"	"32"	"4"	"13"	"4"	"143"	"15.1"	"10.74"	"1937.94"	"23.26"	"3"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00125, Pf16211"	"3014"	"ENSG00000188486"	"H2AX"	"hsa:3014; P16104; Q4ZGJ7; Q6IAS5"	"miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; ATM signaling in development and disease ; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response"	"RUNX1 regulates transcription of genes involved in differentiation of HSCs; RMTs methylate histone arginines; Assembly of the ORC complex at the origin of replication; Amyloid fiber formation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis"	"46"	"0"	"575.4"	"356.3"	"457.4"	"541.1"	"769.9"	"639.8"	"4848.8"	"4608.5"	"1999.3"	"2767.6"	"3457.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13667"	"Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2"	"14"	"9"	"17"	"8"	"645"	"72.9"	"5.07"	"3280.09"	"23.18"	"9"	"8"	"protein metabolism;other metabolic processes;stress response;transport"	"non-structural extracellular;ER/Golgi;other cell component"	"other molecular function"	"Pf00085, Pf13848"	"9601"	"ENSG00000155660"	"PDIA4"	"A8K4K6; hsa:9601; P13667; Q549T6"	""	""	"0"	"1"	"443.8"	"306.5"	"427.5"	"494.3"	"604.9"	"620.2"	"1489.9"	"1413.7"	"932.2"	"1198.4"	"1893.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75822"	"Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2"	"30"	"7"	"11"	"7"	"258"	"29.0"	"4.83"	"2049.76"	"23.14"	"5"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf08597"	"8669"	"ENSG00000104131"	"EIF3J"	"B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"8"	"0"	"352.1"	"198.3"	"330.1"	"406.5"	"524.7"	"445.2"	"1598.4"	"1613.2"	"954.7"	"1230.0"	"1622.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19367"	"Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3"	"12"	"10"	"16"	"10"	"917"	"102.4"	"6.80"	"3076.92"	"23.09"	"8"	"8"	"other metabolic processes;stress response;other biological processes"	"other membranes;cytosol;mitochondrion"	"kinase activity;other molecular function"	"Pf00349, Pf03727"	"3098"	"ENSG00000156515"	"HK1"	"E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5"	"Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation"	"Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)"	"12"	"0"	"340.7"	"264.5"	"381.0"	"699.1"	"829.6"	"721.2"	"1317.7"	"1262.3"	"801.7"	"969.1"	"1193.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96KR1"	"Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2"	"8"	"7"	"12"	"7"	"1074"	"116.9"	"9.04"	"2140.80"	"23.02"	"6"	"6"	""	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf07528, Pf12874"	"51663"	"ENSG00000056097"	"ZFR"	"B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687"	"Exercise-induced circadian regulation"	""	"1"	"0"	"262.0"	"159.4"	"242.2"	"316.1"	"408.5"	"342.7"	"975.3"	"893.1"	"597.0"	"784.5"	"955.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q07020"	"60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2"	"35"	"6"	"14"	"6"	"188"	"21.6"	"11.72"	"2293.17"	"22.94"	"6"	"6"	"protein metabolism;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf17135"	"6141"	"ENSG00000063177"	"RPL18"	"F8VWC5; hsa:6141; Q07020; Q8WTZ6"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"366.6"	"232.7"	"339.8"	"436.6"	"575.9"	"462.2"	"1684.9"	"1537.8"	"903.5"	"1242.6"	"1681.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62913"	"60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2"	"26"	"5"	"12"	"5"	"178"	"20.2"	"9.60"	"1975.42"	"22.89"	"3"	"5"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00281, Pf00673"	"6135"	"ENSG00000142676"	"RPL11"	"hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"537.4"	"322.9"	"478.1"	"570.1"	"696.4"	"568.8"	"2874.1"	"2530.1"	"1632.2"	"2045.5"	"2303.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62750"	"60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1"	"41"	"6"	"16"	"6"	"156"	"17.7"	"10.45"	"2710.41"	"22.89"	"6"	"5"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00276, Pf03939"	"6147"	"ENSG00000198242"	"RPL23A"	"B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"340.1"	"214.1"	"340.0"	"402.2"	"521.6"	"449.8"	"2288.7"	"2047.8"	"1406.3"	"1758.0"	"1896.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92598"	"Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1"	"10"	"7"	"12"	"6"	"858"	"96.8"	"5.39"	"1663.33"	"22.81"	"5"	"7"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00012"	"10808"	"ENSG00000120694"	"HSPH1"	"B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4"	""	"Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors"	"2"	"0"	"222.0"	"150.3"	"245.5"	"339.8"	"411.1"	"390.3"	"641.7"	"669.3"	"379.1"	"559.7"	"765.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVZ3"	"Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1"	"21"	"5"	"13"	"5"	"263"	"28.3"	"8.38"	"2164.36"	"22.77"	"5"	"5"	"transport"	"plasma membrane;other membranes"	""	"Pf07933"	"55707"	"ENSG00000157191"	"NECAP2"	"B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3"	""	"Cargo recognition for clathrin-mediated endocytosis"	"2"	"0"	"120.7"	"79.8"	"115.1"	"150.1"	"189.9"	"170.2"	"539.3"	"1107.1"	"1684.8"	"2682.1"	"4171.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63151"	"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1"	"19"	"8"	"14"	"8"	"447"	"51.7"	"6.20"	"1968.42"	"22.76"	"6"	"8"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity"	""	"5520"	"ENSG00000221914"	"PPP2R2A"	"B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007"	"Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation"	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation"	"7"	"0"	"258.5"	"177.5"	"276.9"	"395.5"	"462.3"	"442.6"	"947.1"	"976.8"	"551.4"	"728.6"	"985.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14166"	"Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2"	"14"	"6"	"10"	"6"	"644"	"74.4"	"5.53"	"1228.46"	"22.71"	"4"	"6"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf03133"	"23170"	"ENSG00000100304"	"TTLL12"	"hsa:23170; Q14166; Q20WK5; Q9UGU3"	""	"Carboxyterminal post-translational modifications of tubulin"	"1"	"0"	"131.0"	"89.8"	"132.3"	"184.5"	"232.1"	"207.0"	"444.9"	"481.4"	"285.6"	"322.7"	"359.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P98175"	"RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3"	"9"	"8"	"14"	"8"	"930"	"103.5"	"5.97"	"2774.98"	"22.70"	"7"	"7"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf00641, Pf01585, Pf17780"	"8241"	"ENSG00000182872"	"RBM10"	"A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1"	""	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"2"	"0"	"513.1"	"368.8"	"515.8"	"801.6"	"902.8"	"737.6"	"2132.7"	"1820.5"	"1190.1"	"1457.0"	"1806.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60869"	"Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1"	"32"	"6"	"16"	"6"	"148"	"16.4"	"9.95"	"3104.54"	"22.50"	"6"	"4"	"other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01381, Pf08523"	"8721"	"ENSG00000107223"	"EDF1"	"hsa:8721; O60869; Q5T5T2; Q9UIM1"	""	""	"0"	"0"	"284.5"	"153.3"	"255.2"	"296.2"	"398.9"	"351.6"	"4119.1"	"4195.8"	"3045.5"	"3121.6"	"4616.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61604"	"10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2"	"63"	"8"	"19"	"8"	"102"	"10.9"	"8.92"	"3556.16"	"22.33"	"8"	"7"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"mitochondrion"	"other molecular function"	"Pf00166"	"3336"	"ENSG00000115541"	"HSPE1"	"hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0"	""	"RHOG GTPase cycle"	"1"	"0"	"466.5"	"334.7"	"501.5"	"640.7"	"714.8"	"787.5"	"1230.8"	"1864.4"	"1106.5"	"1358.9"	"2849.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62841"	"40S ribosomal protein S15 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2"	"42"	"3"	"10"	"3"	"145"	"17.0"	"10.39"	"1668.06"	"22.29"	"1"	"3"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00203"	"6209"	"ENSG00000115268"	"RPS15"	"A5D8V9; hsa:6209; P11174; P62841; Q3KRA1; Q9UDC2"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"243.6"	"139.4"	"226.3"	"274.3"	"358.7"	"307.8"	"1411.5"	"1234.4"	"733.6"	"899.1"	"1202.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6PD62"	"RNA polymerase-associated protein CTR9 homolog OS=Homo sapiens OX=9606 GN=CTR9 PE=1 SV=1"	"8"	"9"	"15"	"9"	"1173"	"133.4"	"6.77"	"2395.94"	"22.28"	"8"	"7"	"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf13181"	"9646"	"ENSG00000198730"	"CTR9"	"D3DQV8; hsa:9646; Q15015; Q6PD62"	"Endoderm differentiation"	"E3 ubiquitin ligases ubiquitinate target proteins; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex"	"5"	"0"	"347.4"	"196.7"	"311.7"	"462.8"	"558.5"	"483.8"	"1777.7"	"1743.1"	"1110.7"	"1422.1"	"1787.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62937"	"Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2"	"58"	"8"	"14"	"8"	"165"	"18.0"	"7.81"	"2275.79"	"22.26"	"6"	"6"	"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00160"	"5478"	"ENSG00000196262"	"PPIA"	"A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61"	"Prolactin signaling pathway"	"Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis"	"16"	"0"	"686.7"	"576.3"	"839.6"	"827.2"	"999.0"	"1104.1"	"1656.4"	"1469.9"	"1024.7"	"1520.9"	"3438.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NFH3"	"Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1"	"20"	"6"	"11"	"6"	"380"	"42.1"	"5.63"	"1936.21"	"22.23"	"5"	"6"	"cell cycle OR cell proliferation;transport;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf00400"	"348995"	"ENSG00000120253"	"NUP43"	"B4E2F0; hsa:348995; Q8NFH3; Q9H8S0"	""	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Early Events; tRNA processing in the nucleus; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation"	"35"	"0"	"98.1"	"62.8"	"100.1"	"154.1"	"175.2"	"163.0"	"459.3"	"467.0"	"222.1"	"278.0"	"434.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P21127"	"Cyclin-dependent kinase 11B OS=Homo sapiens OX=9606 GN=CDK11B PE=1 SV=4"	"9"	"8"	"17"	"8"	"795"	"92.6"	"5.54"	"2926.07"	"22.15"	"8"	"7"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"984"	"ENSG00000248333"	"CDK11B"	"B7ZVY7; hsa:984; J3KTL7; J3QR29; J3QR44; O95265; P21127; Q12817; Q12818; Q12819; Q12820; Q12822; Q8N530; Q9NZS5; Q9UBJ0; Q9UBQ1; Q9UBR0; Q9UNY2; Q9UP57; Q9UP58; Q9UP59"	"1p36 copy number variation syndrome"	"Recruitment of mitotic centrosome proteins and complexes"	"2"	"0"	"298.6"	"191.6"	"255.5"	"351.6"	"491.4"	"437.6"	"1179.9"	"1117.3"	"720.3"	"1054.4"	"1450.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26639"	"Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3"	"11"	"6"	"11"	"6"	"723"	"83.4"	"6.67"	"1311.14"	"22.05"	"4"	"6"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol"	"nucleic acid binding activity;other molecular function"	"Pf00587, Pf02824, Pf03129, Pf07973"	"6897"	"ENSG00000113407"	"TARS1"	"A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6"	""	"Cytosolic tRNA aminoacylation"	"1"	"0"	"84.8"	"56.5"	"86.4"	"103.9"	"154.1"	"134.8"	"393.1"	"464.0"	"259.2"	"471.1"	"1649.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07814"	"Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5"	"6"	"8"	"14"	"8"	"1512"	"170.5"	"7.33"	"2611.60"	"21.98"	"6"	"6"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00043, Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180"	"2058"	"ENSG00000136628"	"EPRS1"	"A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73"	"Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism"	"tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation"	"6"	"0"	"375.7"	"271.0"	"406.2"	"645.5"	"750.4"	"658.0"	"1360.7"	"1254.7"	"840.0"	"1175.0"	"1253.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61158"	"Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3"	"23"	"7"	"13"	"7"	"418"	"47.3"	"5.88"	"1959.96"	"21.93"	"6"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00022"	"10096"	"ENSG00000115091"	"ACTR3"	"hsa:10096; P32391; P61158; Q53QM2"	"Physico-chemical features and toxicity-associated pathways"	"EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis"	"6"	"0"	"130.9"	"96.6"	"135.9"	"178.6"	"222.4"	"253.9"	"632.9"	"773.3"	"562.4"	"897.5"	"1999.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99497"	"Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2"	"50"	"8"	"13"	"8"	"189"	"19.9"	"6.79"	"1908.80"	"21.91"	"6"	"7"	"cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf01965"	"11315"	"ENSG00000116288"	"PARK7"	"B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497"	"Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway"	"Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy"	"7"	"0"	"619.2"	"425.5"	"641.0"	"857.3"	"1012.6"	"961.4"	"1618.1"	"1450.0"	"787.2"	"1016.0"	"1552.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05388"	"60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1"	"24"	"6"	"12"	"6"	"317"	"34.3"	"5.97"	"2310.79"	"21.88"	"6"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00428, Pf00466, Pf17777"	"6175"	"ENSG00000089157"	"RPLP0"	"hsa:6175; P05388; Q3B7A4; Q9BVK4"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"152.3"	"85.8"	"147.7"	"184.5"	"236.8"	"196.4"	"667.8"	"642.0"	"381.9"	"542.3"	"712.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60739"	"Eukaryotic translation initiation factor 1b OS=Homo sapiens OX=9606 GN=EIF1B PE=1 SV=2"	"46"	"4"	"9"	"1"	"113"	"12.8"	"7.37"	"1676.36"	"21.84"	"3"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"translational apparatus"	"translation activity;nucleic acid binding activity"	"Pf01253"	"10289"	"ENSG00000114784"	"EIF1B"	"hsa:10289; O60739; Q9UQF8"	""	""	"0"	"3"	"109.1"	"63.7"	"119.7"	"156.8"	"200.6"	"177.9"	"465.8"	"462.5"	"249.3"	"461.9"	"886.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09972"	"Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2"	"20"	"6"	"10"	"1"	"364"	"39.4"	"6.87"	"1226.47"	"21.79"	"4"	"5"	"other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00274"	"230"	"ENSG00000109107"	"ALDOC"	"B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5"	"Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Neutrophil degranulation; Glycolysis; Gluconeogenesis"	"6"	"0"	"9.0"	"8.6"	"12.1"	"14.8"	"16.4"	"17.1"	"30.9"	"33.4"	"17.4"	"26.2"	"39.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P16403"	"Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2"	"27"	"6"	"16"	"1"	"213"	"21.4"	"10.93"	"2932.20"	"21.79"	"6"	"5"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00538"	"3006"	"ENSG00000187837"	"H1-2"	"A8K4I2; hsa:3006; P16403"	""	"Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation"	"2"	"0"	"42.5"	"20.6"	"31.6"	"37.2"	"43.4"	"45.9"	"222.1"	"204.6"	"137.8"	"166.1"	"202.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10412"	"Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2"	"26"	"6"	"16"	"1"	"219"	"21.9"	"11.03"	"2903.11"	"21.79"	"6"	"5"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00538"	"3008"	"ENSG00000168298"	"H1-4"	"hsa:3008; P10412; Q4VB25"	"Pathways affected in adenoid cystic carcinoma"	"Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation"	"3"	"6"	"549.9"	"323.2"	"431.4"	"553.5"	"740.6"	"622.3"	"3509.2"	"3325.5"	"2399.6"	"2972.8"	"3371.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z794"	"Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3"	"9"	"6"	"14"	"2"	"578"	"61.9"	"5.99"	"2418.10"	"21.77"	"6"	"6"	"other biological processes"	"plasma membrane;cytosol;cytoskeleton"	"bone, tooth or skin structural activity"	"Pf00038, Pf16208"	"374454"	"ENSG00000189182"	"KRT77"	"hsa:374454; Q7RTS8; Q7Z794"	""	"Formation of the cornified envelope"	"2"	"0"	"13.5"	"9.8"	"8.6"	"15.1"	"26.6"	"20.0"	"42.2"	"186.0"	"28.5"	"25.6"	"49.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43447"	"Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1"	"35"	"7"	"17"	"7"	"177"	"19.2"	"8.07"	"3147.61"	"21.76"	"7"	"7"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00160"	"10465"	"ENSG00000171960"	"PPIH"	"A6NNE7; hsa:10465; O43447"	""	"mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses"	"2"	"0"	"652.5"	"486.1"	"631.1"	"798.1"	"929.9"	"852.1"	"1649.8"	"1553.5"	"1144.1"	"1413.6"	"1906.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y697"	"Cysteine desulfurase, mitochondrial OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3"	"14"	"5"	"13"	"5"	"457"	"50.2"	"8.31"	"2677.21"	"21.75"	"5"	"4"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;mitochondrion;nucleus"	"other molecular function"	"Pf00266"	"9054"	"ENSG00000244005"	"NFS1"	"B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697"	"Iron-sulfur cluster biogenesis"	""	"1"	"0"	"145.0"	"94.3"	"157.1"	"213.1"	"254.2"	"239.0"	"464.5"	"502.0"	"371.5"	"556.7"	"801.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62424"	"60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2"	"27"	"8"	"15"	"8"	"266"	"30.0"	"10.61"	"2725.03"	"21.65"	"8"	"7"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01248"	"6130"	"ENSG00000148303; ENSG00000280858"	"RPL7A"	"hsa:6130; P11518; P62424; Q5T8U4"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"515.4"	"325.2"	"464.2"	"576.3"	"712.1"	"591.1"	"2896.9"	"2509.6"	"1640.2"	"2083.7"	"2627.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NQ29"	"Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1"	"15"	"6"	"13"	"3"	"371"	"43.7"	"9.92"	"2101.73"	"21.62"	"5"	"6"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf03194"	"55692"	"ENSG00000007392"	"LUC7L"	"B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"117.6"	"79.7"	"113.6"	"144.8"	"177.9"	"159.7"	"542.4"	"531.0"	"325.4"	"428.7"	"512.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96CT7"	"Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1"	"35"	"7"	"12"	"7"	"223"	"25.8"	"9.54"	"2184.46"	"21.52"	"6"	"6"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf06244"	"115098"	"ENSG00000007080"	"CCDC124"	"hsa:115098; Q96CT7"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"306.5"	"177.1"	"278.7"	"349.6"	"472.4"	"389.3"	"2360.9"	"2263.5"	"1370.9"	"1905.2"	"2620.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P39019"	"40S ribosomal protein S19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2"	"34"	"6"	"15"	"6"	"145"	"16.1"	"10.32"	"2933.92"	"21.50"	"6"	"6"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01090"	"6223"	"ENSG00000105372"	"RPS19"	"hsa:6223; P39019"	"Complement system; Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"20"	"0"	"565.1"	"386.2"	"511.3"	"577.4"	"731.9"	"626.1"	"2480.3"	"2282.8"	"1630.7"	"1666.9"	"2102.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2Z4"	"Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2"	"18"	"8"	"14"	"8"	"477"	"53.2"	"8.98"	"2307.77"	"21.46"	"7"	"7"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;mitochondrion;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00579"	"51067"	"ENSG00000139131"	"YARS2"	"D3DUW8; hsa:51067; Q9H817; Q9Y2Z4"	"Orexin receptor pathway"	"Mitochondrial tRNA aminoacylation"	"2"	"0"	"292.5"	"177.0"	"308.3"	"370.5"	"496.2"	"454.6"	"1694.3"	"1727.2"	"1184.6"	"1584.6"	"2835.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50570"	"Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2"	"10"	"7"	"15"	"7"	"870"	"98.0"	"7.44"	"3191.98"	"21.42"	"7"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00169, Pf00350, Pf01031, Pf02212"	"1785"	"ENSG00000079805"	"DNM2"	"A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4"	"Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy"	"Clathrin-mediated endocytosis; MHC class II antigen presentation; Recycling pathway of L1; Lysosome Vesicle Biogenesis; NGF-stimulated transcription; Golgi Associated Vesicle Biogenesis; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions"	"14"	"0"	"171.4"	"125.3"	"197.9"	"291.0"	"348.2"	"284.6"	"826.2"	"1436.8"	"933.1"	"841.7"	"1182.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13347"	"Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1"	"21"	"7"	"13"	"7"	"325"	"36.5"	"5.64"	"2072.29"	"21.29"	"6"	"7"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity"	"Pf00400"	"8668"	"ENSG00000084623"	"EIF3I"	"hsa:8668; Q13347"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition"	"8"	"0"	"452.5"	"350.3"	"467.0"	"462.6"	"575.0"	"532.6"	"1319.8"	"1167.1"	"836.3"	"932.0"	"1073.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12004"	"Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1"	"26"	"7"	"14"	"7"	"261"	"28.8"	"4.69"	"2333.98"	"21.28"	"6"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00705, Pf02747"	"5111"	"ENSG00000132646"	"PCNA"	"B2R897; D3DW02; hsa:5111; P12004"	"Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; A network map of Macrophage-stimulating protein (MSP) signaling"	"HDR through Homologous Recombination (HRR); E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"	"45"	"0"	"679.5"	"505.2"	"773.3"	"1049.3"	"1210.3"	"1184.0"	"2072.8"	"1958.2"	"1232.9"	"1660.6"	"2420.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P41567"	"Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1"	"46"	"4"	"9"	"1"	"113"	"12.7"	"7.44"	"1655.18"	"21.24"	"3"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"translational apparatus;nucleus;other cell component"	"translation activity;nucleic acid binding activity"	"Pf01253"	"10209"	"ENSG00000173812"	"EIF1"	"hsa:10209; P41567; Q9UNQ9"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	""	"2"	"0"	"21.7"	"7.3"	"23.4"	"32.8"	"37.6"	"35.2"	"99.9"	"95.8"	"68.0"	"91.3"	"181.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43427"	"Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3"	"21"	"8"	"16"	"8"	"364"	"41.9"	"6.48"	"3184.09"	"21.23"	"8"	"6"	"signal transduction"	"other membranes;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf05427"	"9158"	"ENSG00000172500"	"FIBP"	"A8K0J7; hsa:9158; O43427; Q27Q85; Q6IBQ3; Q9HD65"	"Modulators of TCR signaling and T cell activation"	""	"1"	"0"	"208.2"	"124.2"	"203.7"	"266.3"	"353.8"	"291.7"	"1430.7"	"3483.5"	"3070.9"	"4938.3"	"6611.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01130"	"Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4"	"15"	"3"	"12"	"3"	"221"	"25.5"	"11.85"	"3052.81"	"21.18"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf00076"	"6427"	"ENSG00000161547"	"SRSF2"	"B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130"	"mRNA processing"	"mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway"	"7"	"0"	"489.5"	"441.1"	"490.6"	"626.7"	"628.5"	"589.3"	"1786.8"	"1402.7"	"928.1"	"943.1"	"849.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61964"	"WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1"	"21"	"5"	"12"	"5"	"334"	"36.6"	"8.27"	"1437.04"	"21.11"	"4"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00400"	"11091"	"ENSG00000196363"	"WDR5"	"hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9"	"Pleural mesothelioma; Kleefstra syndrome"	"Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Formation of WDR5-containing histone-modifying complexes; RMTs methylate histone arginines; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis"	"10"	"0"	"128.4"	"73.4"	"131.0"	"189.2"	"187.4"	"180.3"	"558.5"	"562.9"	"371.8"	"492.5"	"723.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52209"	"6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3"	"14"	"7"	"15"	"7"	"483"	"53.1"	"7.23"	"2288.22"	"21.09"	"7"	"7"	"other metabolic processes"	"cytosol"	"other molecular function"	"Pf00393, Pf03446"	"5226"	"ENSG00000142657"	"PGD"	"A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8"	"Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer"	"NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway"	"7"	"0"	"585.3"	"354.9"	"517.4"	"802.2"	"949.2"	"913.4"	"1486.0"	"1673.7"	"971.8"	"1345.3"	"3044.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15372"	"Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1"	"23"	"6"	"14"	"6"	"352"	"39.9"	"6.54"	"2437.71"	"21.07"	"6"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01398, Pf19445"	"8667"	"ENSG00000147677"	"EIF3H"	"hsa:8667; O15372"	"Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"10"	"0"	"210.8"	"131.7"	"208.8"	"230.4"	"299.5"	"273.2"	"662.4"	"607.9"	"412.3"	"499.7"	"652.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P68431"	"Histone H3.1 OS=Homo sapiens OX=9606 GN=H3C1 PE=1 SV=2"	"53"	"7"	"13"	"1"	"136"	"15.4"	"11.12"	"2201.10"	"21.05"	"6"	"5"	"cell organization and biogenesis;other metabolic processes"	"non-structural extracellular;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00125"	"8350; 8351; 8352; 8353; 8354; 8355; 8356; 8357; 8358; 8968"	"ENSG00000197153; ENSG00000197409; ENSG00000273983; ENSG00000274750; ENSG00000275379; ENSG00000275714; ENSG00000277775; ENSG00000278828; ENSG00000286522; ENSG00000287080"	"H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8"	"A0PJT7; A5PLR1; hsa:8350; hsa:8351; hsa:8352; hsa:8353; hsa:8354; hsa:8355; hsa:8356; hsa:8357; hsa:8358; hsa:8968; P02295; P02296; P16106; P68431; Q6ISV8; Q6NWP8; Q6NWP9; Q6NXU4; Q71DJ3; Q93081"	"Histone modifications; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma"	"Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Late Events; HCMV Early Events; Amyloid fiber formation; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Meiotic recombination; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Interleukin-7 signaling; RMTs methylate histone arginines; PKMTs methylate histone lysines"	"36"	"7"	"520.7"	"316.2"	"401.5"	"518.9"	"749.2"	"649.5"	"2554.0"	"2409.4"	"1342.5"	"1868.9"	"2791.6"	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P33993"	"DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4"	"13"	"8"	"14"	"8"	"719"	"81.3"	"6.46"	"3000.42"	"21.03"	"7"	"7"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00493, Pf14551, Pf17207, Pf17855"	"4176"	"ENSG00000166508"	"MCM7"	"A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1"	"miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication"	"Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA"	"12"	"0"	"298.8"	"203.6"	"325.2"	"371.4"	"508.8"	"475.5"	"858.6"	"756.3"	"441.3"	"646.9"	"890.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60306"	"RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4"	"5"	"7"	"15"	"6"	"1485"	"171.2"	"6.37"	"2946.25"	"21.01"	"7"	"6"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf13086, Pf13087, Pf16399"	"9716"	"ENSG00000021776"	"AQR"	"A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8"	""	"mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER"	"5"	"0"	"91.6"	"80.3"	"91.7"	"121.8"	"163.3"	"133.0"	"271.4"	"257.8"	"176.0"	"243.1"	"320.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52948"	"Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4"	"5"	"8"	"16"	"8"	"1817"	"197.5"	"6.40"	"2676.94"	"21.00"	"8"	"6"	"cell organization and biogenesis;protein metabolism;transport;other biological processes"	"other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04096, Pf12110"	"4928"	"ENSG00000110713"	"NUP98"	"hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5"	"SARS-CoV-2 innate immunity evasion and cell-specific immune response"	""	"1"	"0"	"268.3"	"193.3"	"277.6"	"471.9"	"566.2"	"432.2"	"961.3"	"905.1"	"558.1"	"733.2"	"781.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6UXN9"	"WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1"	"18"	"6"	"12"	"6"	"313"	"35.1"	"7.69"	"1944.27"	"20.99"	"5"	"5"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00400"	"80335"	"ENSG00000164091"	"WDR82"	"A8K5R5; hsa:80335; Q6UXN9; Q8TEB2"	""	"Formation of WDR5-containing histone-modifying complexes"	"1"	"0"	"458.3"	"337.5"	"369.4"	"511.3"	"704.4"	"649.2"	"1045.7"	"1064.7"	"662.8"	"956.3"	"1383.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02878"	"60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3"	"21"	"6"	"14"	"6"	"288"	"32.7"	"10.58"	"2469.85"	"20.95"	"6"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01159, Pf03868"	"6128"	"ENSG00000089009"	"RPL6"	"hsa:6128; Q02878; Q2M3Q3; Q8WW97"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"510.4"	"351.0"	"493.7"	"547.4"	"670.7"	"565.4"	"2721.0"	"2471.3"	"1804.9"	"2199.6"	"2460.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96A72"	"Protein mago nashi homolog 2 OS=Homo sapiens OX=9606 GN=MAGOHB PE=1 SV=1"	"49"	"7"	"14"	"7"	"148"	"17.3"	"6.39"	"2524.28"	"20.88"	"7"	"7"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf02792"	"55110"	"ENSG00000111196"	"MAGOHB"	"hsa:55110; Q96A72"	""	"Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"	"6"	"0"	"330.6"	"216.1"	"305.5"	"427.7"	"544.0"	"459.8"	"1016.1"	"865.8"	"524.3"	"1079.9"	"1339.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12996"	"Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1"	"15"	"8"	"13"	"8"	"717"	"82.9"	"8.12"	"2507.30"	"20.86"	"6"	"7"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf05843"	"1479"	"ENSG00000176102"	"CSTF3"	"A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4"	"mRNA processing"	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs"	"5"	"0"	"134.0"	"91.1"	"155.6"	"181.1"	"249.2"	"222.9"	"855.6"	"796.3"	"484.4"	"641.9"	"809.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15427"	"Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1"	"17"	"5"	"11"	"5"	"424"	"44.4"	"8.56"	"1594.48"	"20.86"	"4"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf00076"	"10262"	"ENSG00000143368"	"SF3B4"	"hsa:10262; Q15427; Q5SZ63"	"mRNA processing; 10q22q23 copy number variation"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"4"	"0"	"308.7"	"209.7"	"313.0"	"369.4"	"504.2"	"440.3"	"1317.7"	"1203.9"	"839.6"	"1211.4"	"1299.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NQG5"	"Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1"	"25"	"6"	"11"	"4"	"326"	"36.9"	"5.97"	"1775.77"	"20.61"	"5"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf04818, Pf16566"	"58490"	"ENSG00000101413"	"RPRD1B"	"hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5"	"Modulators of TCR signaling and T cell activation"	"RNA polymerase II transcribes snRNA genes"	"2"	"0"	"132.8"	"107.4"	"150.8"	"230.4"	"290.0"	"218.4"	"712.0"	"721.8"	"493.5"	"646.6"	"794.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NFH4"	"Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1"	"17"	"4"	"10"	"4"	"326"	"36.7"	"5.92"	"2345.87"	"20.58"	"4"	"4"	"cell cycle OR cell proliferation;transport;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf00400"	"79023"	"ENSG00000075188"	"NUP37"	"hsa:79023; Q8NFH4; Q9H644"	""	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Early Events; tRNA processing in the nucleus; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation"	"35"	"0"	"199.8"	"130.2"	"190.8"	"255.2"	"281.3"	"259.2"	"562.5"	"576.1"	"393.7"	"513.8"	"669.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P2J5"	"Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2"	"6"	"6"	"15"	"6"	"1176"	"134.4"	"7.30"	"2123.65"	"20.54"	"6"	"6"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00133, Pf08264"	"51520"	"ENSG00000133706"	"LARS1"	"A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5"	""	"Selenoamino acid metabolism; Cytosolic tRNA aminoacylation"	"2"	"0"	"158.6"	"98.8"	"182.4"	"297.2"	"347.0"	"299.6"	"474.4"	"460.2"	"251.7"	"348.9"	"422.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19388"	"DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4"	"28"	"5"	"12"	"5"	"210"	"24.5"	"5.95"	"2347.52"	"20.51"	"5"	"5"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01191, Pf03871"	"5434"	"ENSG00000099817"	"POLR2E"	"B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06"	"Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome"	"mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM"	"57"	"0"	"297.1"	"209.0"	"295.3"	"410.7"	"499.7"	"449.4"	"1143.1"	"1405.9"	"1217.0"	"1711.3"	"2190.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86VM9"	"Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2"	"7"	"8"	"14"	"8"	"953"	"106.3"	"8.32"	"1890.23"	"20.43"	"6"	"8"	"other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf18044"	"124245"	"ENSG00000158545"	"ZC3H18"	"hsa:124245; Q86VM9; Q96DG4; Q96MP7"	""	""	"0"	"0"	"220.2"	"150.9"	"202.9"	"312.2"	"375.3"	"317.2"	"2553.6"	"2434.2"	"1936.9"	"2258.4"	"2409.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15181"	"Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2"	"29"	"5"	"7"	"5"	"289"	"32.6"	"5.86"	"736.59"	"20.42"	"2"	"5"	"other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf00719"	"5464"	"ENSG00000180817"	"PPA1"	"hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1"	""	"Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis"	"2"	"0"	"134.6"	"95.4"	"145.5"	"177.2"	"210.2"	"206.2"	"380.1"	"358.9"	"253.3"	"385.2"	"930.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N684"	"Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1"	"17"	"7"	"13"	"7"	"471"	"52.0"	"8.00"	"2484.33"	"20.40"	"7"	"6"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"79869"	"ENSG00000149532"	"CPSF7"	"B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1"	""	"RHOBTB1 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs"	"5"	"0"	"416.8"	"290.3"	"375.0"	"467.9"	"627.3"	"547.4"	"1468.7"	"1401.0"	"907.0"	"1235.1"	"1666.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NYL9"	"Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1"	"19"	"5"	"10"	"4"	"352"	"39.6"	"5.19"	"2389.38"	"20.38"	"5"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytoskeleton"	"cytoskeletal activity"	"Pf03250"	"29766"	"ENSG00000138594"	"TMOD3"	"B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0"	"VEGFA-VEGFR2 signaling"	"RND3 GTPase cycle; Striated Muscle Contraction; RHOBTB2 GTPase cycle"	"4"	"1"	"252.0"	"164.7"	"236.9"	"305.1"	"381.5"	"349.7"	"812.6"	"884.4"	"601.6"	"721.9"	"1040.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13995"	"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2"	"20"	"7"	"14"	"7"	"350"	"37.9"	"8.73"	"2371.01"	"20.35"	"7"	"7"	"other metabolic processes"	"mitochondrion"	"other molecular function"	"Pf00763, Pf02882"	"10797"	"ENSG00000065911"	"MTHFD2"	"hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650"	"Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways"	"Metabolism of folate and pterines"	"4"	"0"	"480.3"	"339.5"	"499.3"	"707.0"	"871.2"	"737.9"	"2016.8"	"2012.2"	"1195.9"	"1467.2"	"1728.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P53680"	"AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2"	"27"	"4"	"15"	"4"	"142"	"17.0"	"6.18"	"2309.49"	"20.31"	"4"	"3"	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf01217"	"1175"	"ENSG00000042753"	"AP2S1"	"B2R4Z4; hsa:1175; O75977; P53680; Q6PK67"	"Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome"	"MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Potential therapeutics for SARS; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation"	"18"	"0"	"79.5"	"51.6"	"85.0"	"120.3"	"146.1"	"115.0"	"429.2"	"747.1"	"1151.9"	"1843.2"	"2553.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P258"	"Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2"	"14"	"7"	"15"	"7"	"522"	"56.0"	"8.78"	"3052.69"	"20.30"	"7"	"5"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00415"	"55920"	"ENSG00000179051; ENSG00000281540"	"RCC2"	"hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258"	""	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"6"	"0"	"397.6"	"252.3"	"359.7"	"421.4"	"549.3"	"487.0"	"3714.8"	"3088.0"	"1560.0"	"1486.4"	"2025.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5S9"	"RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1"	"17"	"2"	"12"	"2"	"174"	"19.9"	"5.72"	"3737.73"	"20.28"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"9939"	"ENSG00000265241"	"RBM8A"	"B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9"	""	"mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing"	"6"	"0"	"87.4"	"82.9"	"87.3"	"99.2"	"132.1"	"126.6"	"236.7"	"193.1"	"164.9"	"280.4"	"336.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15355"	"Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1"	"14"	"6"	"12"	"6"	"546"	"59.2"	"4.36"	"1499.53"	"20.17"	"4"	"6"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;nucleus;other cell component"	"other molecular function"	"Pf00481"	"5496"	"ENSG00000115241"	"PPM1G"	"hsa:5496; O15355"	"VEGFA-VEGFR2 signaling; mRNA processing"	""	"2"	"0"	"146.4"	"94.6"	"137.2"	"187.4"	"244.7"	"205.4"	"730.4"	"717.7"	"459.6"	"547.0"	"625.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62829"	"60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1"	"65"	"7"	"12"	"7"	"140"	"14.9"	"10.51"	"2287.38"	"20.14"	"6"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00238"	"9349"	"ENSG00000125691"	"RPL23"	"hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1"	"Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"395.8"	"267.8"	"360.6"	"482.0"	"576.5"	"515.1"	"1758.6"	"1586.3"	"958.7"	"1318.1"	"1556.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9GZS1"	"DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3"	"10"	"5"	"11"	"5"	"419"	"47.2"	"8.94"	"1451.30"	"20.06"	"4"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf06870"	"64425"	"ENSG00000137054"	"POLR1E"	"hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1"	"Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination"	"8"	"0"	"143.7"	"93.7"	"140.9"	"179.4"	"243.2"	"198.2"	"607.7"	"1098.5"	"1389.7"	"1982.3"	"2447.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P32969"	"60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1"	"30"	"4"	"12"	"4"	"192"	"21.9"	"9.95"	"2881.96"	"19.97"	"4"	"4"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00347"	"6133"	"ENSG00000163682"	"RPL9; RPL9P7; RPL9P8; RPL9P9"	"hsa:6133; P32969"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"200.7"	"117.2"	"159.0"	"190.4"	"236.5"	"220.1"	"716.6"	"632.8"	"411.4"	"576.1"	"691.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49321"	"Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2"	"7"	"6"	"14"	"6"	"788"	"85.2"	"4.30"	"2815.41"	"19.96"	"6"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf10516"	"4678"	"ENSG00000132780"	"NASP"	"A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2"	""	""	"0"	"0"	"539.1"	"367.8"	"526.0"	"807.4"	"966.2"	"881.4"	"1756.0"	"1620.0"	"1063.4"	"1382.3"	"1823.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P84243"	"Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3A PE=1 SV=2"	"53"	"7"	"13"	"1"	"136"	"15.3"	"11.27"	"2201.10"	"19.92"	"6"	"5"	"cell organization and biogenesis;other biological processes"	"non-structural extracellular;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00125"	"3020; 3021"	"ENSG00000132475; ENSG00000163041"	"H3-3A; H3-3B"	"hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4"	"Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation"	"Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Amyloid fiber formation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Meiotic recombination; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis"	"34"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P36957"	"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4"	"13"	"5"	"11"	"5"	"453"	"48.7"	"8.95"	"1861.35"	"19.86"	"4"	"5"	"protein metabolism;other metabolic processes"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00198, Pf00364"	"1743"	"ENSG00000119689"	"DLST"	"B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32"	"TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)"	"Citric acid cycle (TCA cycle); Glyoxylate metabolism and glycine degradation; Lysine catabolism"	"10"	"0"	"344.5"	"221.2"	"305.2"	"406.5"	"491.3"	"429.5"	"1030.1"	"987.0"	"626.1"	"807.2"	"1126.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75663"	"TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2"	"28"	"6"	"11"	"6"	"272"	"31.4"	"5.91"	"1870.87"	"19.79"	"5"	"6"	"stress response;signal transduction;other biological processes"	"cytosol"	""	"Pf04176"	"261726"	"ENSG00000143155"	"TIPRL"	"B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86"	"Ciliary landscape"	""	"1"	"0"	"273.4"	"212.5"	"334.9"	"609.7"	"668.9"	"647.5"	"1050.2"	"1053.5"	"691.6"	"846.2"	"1060.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P33240"	"Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1"	"15"	"6"	"11"	"6"	"577"	"60.9"	"6.83"	"1903.31"	"19.68"	"5"	"6"	"other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076, Pf14304, Pf14327"	"1478"	"ENSG00000101811"	"CSTF2"	"hsa:1478; P33240; Q5H951; Q6LA74; Q8N502"	"mRNA processing"	"tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs"	"6"	"0"	"360.1"	"231.3"	"334.4"	"470.2"	"561.2"	"501.2"	"1275.4"	"1168.5"	"728.1"	"939.0"	"1248.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10599"	"Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3"	"52"	"5"	"9"	"5"	"105"	"11.7"	"4.92"	"1344.44"	"19.67"	"2"	"5"	"other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00085"	"7295"	"ENSG00000136810"	"TXN"	"B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5"	"Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome"	"Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair"	"19"	"0"	"483.7"	"314.4"	"472.4"	"579.1"	"659.5"	"607.0"	"1035.3"	"1138.2"	"614.1"	"905.0"	"1599.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13185"	"Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4"	"39"	"6"	"12"	"4"	"183"	"20.8"	"5.33"	"2767.45"	"19.66"	"6"	"5"	"cell organization and biogenesis;stress response;other biological processes"	"other membranes;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00385, Pf01393"	"11335"	"ENSG00000122565"	"CBX3"	"hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6"	"Exercise-induced circadian regulation; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome"	"RNA Polymerase I Promoter Escape; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Transcriptional Regulation by E2F6"	"6"	"2"	"563.6"	"352.0"	"549.2"	"754.7"	"851.8"	"939.0"	"1709.7"	"1584.2"	"996.7"	"1498.4"	"2245.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKK9"	"ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1"	"25"	"6"	"13"	"6"	"219"	"24.3"	"4.94"	"2467.18"	"19.61"	"6"	"5"	"cell organization and biogenesis;other metabolic processes"	"cytosol;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00293"	"11164"	"ENSG00000165609"	"NUDT5"	"A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9"	""	"Phosphate bond hydrolysis by NUDT proteins"	"1"	"0"	"354.3"	"197.8"	"321.9"	"399.1"	"487.3"	"452.6"	"724.5"	"740.5"	"411.7"	"593.7"	"988.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P37108"	"Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2"	"37"	"7"	"19"	"7"	"136"	"14.6"	"10.04"	"4353.47"	"19.52"	"7"	"4"	"transport"	"non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02290"	"6727"	"ENSG00000140319"	"SRP14"	"B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14"	""	"Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane"	"2"	"0"	"266.5"	"187.7"	"283.5"	"345.0"	"420.1"	"345.4"	"2542.6"	"3192.6"	"3791.4"	"6935.2"	"9896.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14240"	"Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2"	"15"	"8"	"18"	"1"	"407"	"46.4"	"5.48"	"3290.19"	"19.45"	"7"	"6"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"1974"	"ENSG00000156976"	"EIF4A2"	"D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8"	"Translation factors; Translation inhibitors in chronically activated PDGFRA cells"	"L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism; Translation initiation complex formation; Ribosomal scanning and start codon recognition"	"9"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96NC0"	"Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1"	"23"	"7"	"17"	"7"	"199"	"23.6"	"9.01"	"2871.52"	"19.41"	"7"	"5"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf12171"	"153527"	"ENSG00000146007"	"ZMAT2"	"hsa:153527; Q96NC0"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"416.1"	"223.5"	"378.4"	"573.1"	"727.5"	"590.1"	"5033.3"	"4599.9"	"2844.2"	"3472.1"	"3837.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16629"	"Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1"	"25"	"5"	"10"	"5"	"238"	"27.4"	"11.82"	"860.04"	"19.40"	"2"	"5"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"6432"	"ENSG00000115875"	"SRSF7"	"B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3"	"mRNA processing"	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"7"	"0"	"374.4"	"274.6"	"323.7"	"463.4"	"574.8"	"471.5"	"1441.7"	"1450.0"	"1168.4"	"2466.8"	"3037.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23921"	"Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1"	"7"	"4"	"9"	"4"	"792"	"90.0"	"7.15"	"1576.40"	"19.38"	"3"	"4"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion"	"other molecular function"	"Pf00317, Pf02867, Pf03477"	"6240"	"ENSG00000167325"	"RRM1"	"hsa:6240; P23921; Q9UNN2"	"Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism"	"Interconversion of nucleotide di- and triphosphates"	"4"	"0"	"102.8"	"56.9"	"99.0"	"127.1"	"167.3"	"137.5"	"298.4"	"343.3"	"226.5"	"307.9"	"456.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14927"	"Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2"	"44"	"4"	"10"	"4"	"111"	"13.5"	"8.78"	"2228.89"	"19.37"	"4"	"4"	"other metabolic processes;transport"	"other membranes;mitochondrion"	""	"Pf02271"	"7381"	"ENSG00000156467"	"UQCRB"	"E5RJU0; hsa:7381; P14927; Q6FGD1"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly"	"Respiratory electron transport"	"4"	"0"	"51.6"	"31.9"	"63.8"	"84.3"	"106.9"	"90.8"	"447.1"	"405.5"	"458.2"	"470.3"	"416.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49327"	"Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3"	"3"	"6"	"10"	"6"	"2511"	"273.3"	"6.44"	"1330.58"	"19.34"	"4"	"6"	"other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf14765, Pf16197"	"2194"	"ENSG00000169710"	"FASN"	"hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0"	"AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway"	"ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism"	"18"	"0"	"85.9"	"45.9"	"79.5"	"101.4"	"128.6"	"114.2"	"207.9"	"198.2"	"125.6"	"173.6"	"207.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BWS9"	"Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1"	"13"	"6"	"12"	"6"	"393"	"44.9"	"8.63"	"1979.89"	"19.24"	"5"	"5"	"other metabolic processes;stress response;other biological processes"	"non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00704"	"66005"	"ENSG00000177830"	"CHID1"	"B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52"	""	"Platelet degranulation"	"1"	"0"	"166.6"	"105.5"	"156.1"	"209.1"	"308.7"	"255.7"	"2596.1"	"2583.1"	"1782.6"	"2463.5"	"4621.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P67870"	"Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1"	"27"	"5"	"10"	"5"	"215"	"24.9"	"5.55"	"2017.70"	"19.22"	"5"	"5"	"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function"	"Pf01214"	"1460"	"ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960"	"CSNK2B"	"B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47"	"Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease"	"Neutrophil degranulation; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Synthesis of PC"	"19"	"0"	"155.1"	"98.1"	"145.2"	"213.7"	"229.9"	"227.6"	"1708.5"	"1941.0"	"1301.0"	"1697.5"	"1913.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49750"	"YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4"	"3"	"6"	"10"	"6"	"2146"	"241.5"	"6.55"	"1313.00"	"19.18"	"4"	"6"	"other biological processes"	"cytosol;nucleus"	""	"Pf13671"	"56252"	"ENSG00000119596"	"YLPM1"	"hsa:56252; P49750; P49752; Q96I64; Q9P1V7"	""	""	"0"	"0"	"204.6"	"149.4"	"221.6"	"259.2"	"331.1"	"283.5"	"843.7"	"849.7"	"532.7"	"640.8"	"761.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95881"	"Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1"	"43"	"7"	"11"	"7"	"172"	"19.2"	"5.40"	"2318.59"	"19.14"	"6"	"5"	"other biological processes"	"ER/Golgi"	"other molecular function"	"Pf13899"	"51060"	"ENSG00000117862"	"TXNDC12"	"B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50"	""	""	"0"	"0"	"778.6"	"531.4"	"830.7"	"1329.4"	"1467.2"	"1257.0"	"2188.4"	"2254.7"	"1250.4"	"1322.8"	"1491.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75940"	"Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1"	"26"	"5"	"10"	"5"	"238"	"26.7"	"7.24"	"1292.95"	"19.14"	"4"	"5"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf06003"	"10285"	"ENSG00000119953"	"SMNDC1"	"B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"171.6"	"80.8"	"153.5"	"214.1"	"271.7"	"245.6"	"1073.9"	"998.1"	"653.8"	"924.1"	"1250.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00425"	"Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2"	"9"	"4"	"10"	"3"	"579"	"63.7"	"8.87"	"1734.07"	"19.11"	"4"	"4"	"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf00076"	"10643"	"ENSG00000136231"	"IGF2BP3"	"A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1"	""	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"	"1"	"0"	"58.1"	"36.3"	"56.9"	"73.9"	"92.0"	"87.5"	"158.7"	"148.2"	"90.1"	"133.2"	"185.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95819"	"Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2"	"7"	"6"	"10"	"6"	"1239"	"142.0"	"7.46"	"1168.89"	"18.98"	"4"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"other cell component"	"cytoskeletal activity;kinase activity;other molecular function"	"Pf00069, Pf00780"	"9448"	"ENSG00000071054"	"MAP4K4"	"E7ESS2; hsa:9448; O75172; O95819; Q9NST7"	"MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma"	"Oxidative Stress Induced Senescence"	"7"	"0"	"74.0"	"49.5"	"87.3"	"114.4"	"143.9"	"109.9"	"505.0"	"874.8"	"515.8"	"501.0"	"503.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62906"	"60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2"	"25"	"6"	"16"	"6"	"217"	"24.8"	"9.94"	"4351.58"	"18.98"	"6"	"4"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf00687"	"4736"	"ENSG00000198755"	"RPL10A"	"B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"415.3"	"253.6"	"382.9"	"435.1"	"612.3"	"503.2"	"2371.3"	"2121.8"	"1393.8"	"1833.4"	"2156.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46776"	"60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2"	"30"	"5"	"12"	"5"	"148"	"16.6"	"11.00"	"2212.92"	"18.91"	"5"	"5"	"protein metabolism;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;other cell component"	"other molecular function"	"Pf00828"	"6157"	"ENSG00000166441"	"RPL27A"	"B2R4B3; hsa:6157; P46776"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"223.2"	"151.3"	"235.5"	"266.9"	"349.0"	"303.9"	"1339.9"	"1242.7"	"862.9"	"1143.0"	"1110.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BQ61"	"Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1"	"28"	"4"	"7"	"4"	"176"	"18.4"	"9.44"	"858.61"	"18.91"	"2"	"4"	"RNA metabolism OR transcription;other metabolic processes"	""	"nucleic acid binding activity;other molecular function"	""	"79002"	"ENSG00000123144"	"TRIR"	"hsa:79002; Q9BQ61"	""	""	"0"	"0"	"86.5"	"48.3"	"91.3"	"119.0"	"170.0"	"155.1"	"470.7"	"440.8"	"246.5"	"308.3"	"405.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02543"	"60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2"	"27"	"6"	"12"	"6"	"176"	"20.7"	"10.71"	"1977.25"	"18.90"	"6"	"6"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf01775"	"6142"	"ENSG00000105640"	"RPL18A"	"hsa:6142; Q02543"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins"	"Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"266.8"	"169.9"	"231.1"	"283.7"	"387.2"	"323.5"	"1334.9"	"1189.1"	"707.1"	"1001.5"	"1182.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08754"	"Guanine nucleotide-binding protein G(i) subunit alpha OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3"	"14"	"5"	"14"	"2"	"354"	"40.5"	"5.69"	"2153.52"	"18.86"	"5"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00503"	"2773"	"ENSG00000065135"	"GNAI3"	"hsa:2773; P08754; P17539; Q5TZX1"	"Thyroid stimulating hormone (TSH) signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway"	"G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production"	"18"	"3"	"668.0"	"467.0"	"534.7"	"675.3"	"888.2"	"796.8"	"1214.1"	"1326.0"	"919.3"	"1310.4"	"2022.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18859"	"ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1"	"36"	"3"	"7"	"3"	"108"	"12.6"	"9.52"	"1485.93"	"18.73"	"2"	"3"	"other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity"	"Pf05511"	"522"	"ENSG00000154723"	"ATP5PF"	"hsa:522; J3KQ83; P18859"	"Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation"	"Cristae formation; Formation of ATP by chemiosmotic coupling"	"4"	"0"	"69.7"	"50.1"	"70.7"	"108.2"	"103.0"	"113.6"	"201.7"	"209.1"	"158.3"	"189.7"	"240.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11586"	"C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=3"	"10"	"7"	"12"	"7"	"935"	"101.5"	"7.30"	"1968.14"	"18.71"	"6"	"6"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"101.7"	"82.1"	"108.5"	"142.8"	"153.9"	"150.8"	"455.9"	"453.1"	"275.9"	"381.1"	"417.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30405"	"Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1"	"30"	"6"	"13"	"4"	"207"	"22.0"	"9.38"	"1867.85"	"18.68"	"5"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"other membranes;mitochondrion;other cell component"	"other molecular function"	"Pf00160"	"10105"	"ENSG00000108179"	"PPIF"	"hsa:10105; P30405; Q2YDB7; Q5W131"	"Alzheimer's disease and miRNA effects; Alzheimer's disease"	""	"2"	"1"	"809.4"	"503.7"	"734.4"	"1003.5"	"1263.4"	"1103.9"	"2020.8"	"2055.4"	"1247.5"	"1821.4"	"4460.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06493"	"Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3"	"21"	"5"	"10"	"4"	"297"	"34.1"	"8.40"	"2124.21"	"18.55"	"4"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component"	"enzyme regulator activity;kinase activity;other molecular function"	"Pf00069"	"983"	"ENSG00000170312"	"CDK1"	"A8K7C4; C9J497; hsa:983; O60764; P06493"	"miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; ATM signaling in development and disease ; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response"	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1"	"49"	"1"	"220.8"	"147.2"	"222.6"	"335.6"	"404.5"	"354.5"	"1204.4"	"1180.0"	"822.4"	"981.6"	"1354.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16181"	"Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2"	"14"	"5"	"10"	"4"	"437"	"50.6"	"8.63"	"1734.52"	"18.54"	"5"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00735"	"989"	"ENSG00000122545"	"SEPTIN7"	"hsa:989; Q16181; Q52M76; Q6NX50"	""	"MAPK6/MAPK4 signaling"	"1"	"0"	"68.0"	"44.4"	"89.0"	"98.6"	"129.0"	"110.1"	"424.6"	"414.9"	"305.8"	"392.9"	"562.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3Y2"	"Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2"	"19"	"4"	"11"	"4"	"248"	"26.4"	"12.23"	"2301.21"	"18.52"	"4"	"3"	"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf13865"	"26097"	"ENSG00000160679"	"CHTOP"	"D3DV55; hsa:26097; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0; Q9Y3Y2"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"3"	"0"	"228.5"	"145.1"	"221.3"	"274.6"	"379.0"	"331.9"	"888.2"	"709.9"	"438.7"	"803.4"	"865.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52434"	"DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4"	"37"	"6"	"13"	"6"	"150"	"17.1"	"4.68"	"2492.58"	"18.44"	"6"	"5"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf03870"	"5437"	"ENSG00000163882"	"POLR2H"	"C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0"	"Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome"	"mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"57"	"0"	"117.0"	"87.6"	"123.8"	"182.9"	"222.1"	"198.3"	"462.2"	"599.3"	"613.3"	"800.6"	"1045.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62995"	"Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1"	"15"	"5"	"13"	"5"	"288"	"33.6"	"11.25"	"2225.98"	"18.41"	"5"	"4"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"other membranes;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"6434"	"ENSG00000136527"	"TRA2B"	"B4DVK2; D3DNU3; hsa:6434; O15449; P62995; Q15815; Q64283"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle"	"5"	"0"	"386.7"	"264.0"	"271.8"	"340.9"	"496.3"	"408.0"	"1146.8"	"974.4"	"1189.1"	"2686.7"	"3213.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62314"	"Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1"	"37"	"3"	"10"	"3"	"119"	"13.3"	"11.56"	"1953.30"	"18.38"	"3"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf01423"	"6632"	"ENSG00000167088"	"SNRPD1"	"B5BTZ1; hsa:6632; P13641; P62314"	"mRNA processing"	"mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway"	"5"	"0"	"227.6"	"170.5"	"192.9"	"244.1"	"314.7"	"299.5"	"611.3"	"641.6"	"601.6"	"741.0"	"937.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N1G4"	"Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1"	"12"	"5"	"8"	"5"	"583"	"63.4"	"8.28"	"1311.47"	"18.37"	"3"	"5"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	""	"other molecular function"	"Pf00560, Pf03483, Pf12799"	"57470"	"ENSG00000130764"	"LRRC47"	"hsa:57470; Q8N1G4; Q9ULN5"	""	""	"0"	"0"	"83.7"	"55.2"	"95.6"	"113.6"	"138.3"	"124.7"	"629.5"	"602.0"	"377.3"	"533.1"	"599.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P57740"	"Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1"	"11"	"8"	"11"	"8"	"925"	"106.3"	"5.43"	"1464.53"	"18.34"	"4"	"7"	"cell organization and biogenesis;other metabolic processes;transport;developmental processes"	"other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf04121"	"57122"	"ENSG00000111581"	"NUP107"	"B4DZ67; hsa:57122; P57740; Q6PJE1"	"Gastric cancer network 1; Primary ovarian insufficiency"	"Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of RNA binding proteins; Regulation of HSF1-mediated heat shock response; RHO GTPases Activate Formins; HCMV Late Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation"	"37"	"0"	"194.8"	"153.5"	"217.7"	"426.1"	"481.7"	"376.9"	"719.5"	"698.9"	"400.5"	"533.2"	"622.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09234"	"U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1"	"13"	"3"	"10"	"3"	"159"	"17.4"	"9.67"	"1648.00"	"18.34"	"2"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf06220"	"6631"	"ENSG00000124562"	"SNRPC"	"hsa:6631; P09234; Q5TAL3"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"527.9"	"269.2"	"460.6"	"592.1"	"729.5"	"583.4"	"1977.0"	"1838.7"	"795.5"	"1122.4"	"2445.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15424"	"Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4"	"7"	"6"	"12"	"6"	"915"	"102.6"	"5.47"	"2045.72"	"18.32"	"5"	"5"	"cell organization and biogenesis;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf02037"	"6294"	"ENSG00000160633"	"SAFB"	"A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8"	"Interleukin-1 (IL-1) structural pathway"	"SUMOylation of transcription cofactors"	"2"	"0"	"610.2"	"356.7"	"455.8"	"586.7"	"778.6"	"679.0"	"1717.0"	"1280.5"	"716.3"	"1359.2"	"1657.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P45973"	"Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1"	"28"	"4"	"10"	"3"	"191"	"22.2"	"5.86"	"2521.50"	"18.28"	"4"	"4"	"cell organization and biogenesis;stress response;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00385, Pf01393"	"23468"	"ENSG00000094916"	"CBX5"	"B2R8T9; hsa:23468; P45973"	"Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; 22q11.2 copy number variation syndrome"	"Factors involved in megakaryocyte development and platelet production; SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6"	"5"	"0"	"113.7"	"58.1"	"128.9"	"141.5"	"184.1"	"184.1"	"516.8"	"518.3"	"217.8"	"293.1"	"456.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00422"	"Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1"	"51"	"8"	"15"	"8"	"153"	"17.6"	"9.35"	"3395.64"	"18.25"	"7"	"5"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf06487"	"10284"	"ENSG00000150459"	"SAP18"	"B2R494; hsa:10284; O00422; Q2TTR4; Q6IAW9; Q8N606; Q9UF14; X6RAL5"	"Hedgehog signaling pathway"	"Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway"	"5"	"0"	"718.3"	"423.5"	"634.4"	"803.1"	"1020.4"	"878.6"	"2731.0"	"2372.0"	"1752.7"	"3848.7"	"5179.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49458"	"Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2"	"40"	"5"	"10"	"5"	"86"	"10.1"	"7.97"	"1597.41"	"18.20"	"3"	"5"	"transport;other biological processes"	"other membranes;cytosol;ER/Golgi;translational apparatus"	"nucleic acid binding activity;other molecular function"	"Pf05486"	"6726"	"ENSG00000143742"	"SRP9"	"A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0"	""	"SRP-dependent cotranslational protein targeting to membrane"	"1"	"0"	"127.2"	"72.1"	"132.5"	"160.3"	"217.5"	"168.2"	"1133.5"	"1438.8"	"1019.2"	"2298.2"	"4500.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6NZY4"	"Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2"	"6"	"3"	"9"	"3"	"707"	"78.5"	"4.87"	"1897.27"	"18.19"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00098, Pf04046"	"55596"	"ENSG00000033030"	"ZCCHC8"	"hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3"	""	""	"0"	"0"	"90.7"	"61.5"	"92.4"	"146.3"	"148.3"	"139.5"	"282.8"	"288.1"	"175.0"	"242.9"	"289.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q2NL82"	"Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1"	"13"	"7"	"12"	"7"	"804"	"91.8"	"7.42"	"2070.01"	"18.10"	"6"	"6"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04950, Pf08142"	"55720"	"ENSG00000167721"	"TSR1"	"hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"135.4"	"56.6"	"116.9"	"137.9"	"178.8"	"141.5"	"584.3"	"563.1"	"258.5"	"354.1"	"501.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28066"	"Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3"	"26"	"4"	"9"	"4"	"241"	"26.4"	"4.79"	"1490.66"	"18.05"	"3"	"4"	"protein metabolism;other metabolic processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	""	"Pf00227, Pf10584"	"5686"	"ENSG00000143106"	"PSMA5"	"B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"63"	"0"	"91.9"	"56.7"	"85.1"	"109.0"	"145.9"	"124.0"	"331.2"	"345.8"	"201.5"	"309.2"	"435.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95757"	"Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3"	"8"	"6"	"12"	"3"	"839"	"94.5"	"5.88"	"1872.30"	"18.05"	"5"	"6"	"protein metabolism;other metabolic processes;stress response"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00012"	"22824"	"ENSG00000164070"	"HSPA4L"	"A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2"	""	"Regulation of HSF1-mediated heat shock response"	"1"	"1"	"141.5"	"94.7"	"137.6"	"195.0"	"236.6"	"225.0"	"731.0"	"683.3"	"432.2"	"569.9"	"951.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P29692"	"Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5"	"31"	"9"	"17"	"7"	"281"	"31.1"	"5.01"	"4185.02"	"18.03"	"9"	"5"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00736, Pf10587"	"1936"	"ENSG00000104529; ENSG00000273594"	"EEF1D"	"B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38"	"Translation factors"	"Eukaryotic Translation Elongation"	"2"	"0"	"342.6"	"261.7"	"384.1"	"647.7"	"751.2"	"643.1"	"1525.4"	"1424.6"	"933.4"	"1180.4"	"1321.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62495"	"Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3"	"16"	"7"	"14"	"7"	"437"	"49.0"	"5.71"	"2752.18"	"18.00"	"7"	"5"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function"	"Pf03463, Pf03464, Pf03465"	"2107"	"ENSG00000120705"	"ETF1"	"B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1"	"Translation factors"	"Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"5"	"0"	"204.7"	"165.5"	"203.3"	"308.1"	"392.4"	"347.7"	"1097.1"	"1080.6"	"751.6"	"840.3"	"1312.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15084"	"Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1"	"15"	"5"	"10"	"5"	"440"	"48.1"	"5.08"	"2157.26"	"17.97"	"5"	"5"	"protein metabolism;other metabolic processes;stress response"	"non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf00085"	"10130"	"ENSG00000143870"	"PDIA6"	"B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778"	"Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling"	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes"	"5"	"0"	"198.0"	"169.4"	"258.8"	"355.5"	"431.1"	"327.0"	"721.0"	"703.2"	"408.3"	"413.6"	"477.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15160"	"DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1"	"21"	"6"	"11"	"6"	"346"	"39.2"	"5.50"	"1315.31"	"17.95"	"3"	"6"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01000, Pf01193"	"9533"	"ENSG00000171453"	"POLR1C"	"hsa:9533; O15160; O75395; Q5JTE3"	"Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome"	"RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination"	"15"	"0"	"130.3"	"110.1"	"160.5"	"217.6"	"290.1"	"253.3"	"566.0"	"1170.4"	"1386.0"	"2063.5"	"2443.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25685"	"DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4"	"22"	"7"	"13"	"7"	"340"	"38.0"	"8.63"	"2478.55"	"17.94"	"7"	"6"	"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00226, Pf01556"	"3337"	"ENSG00000132002"	"DNAJB1"	"B4DX52; hsa:3337; P25685"	"Nuclear receptors meta-pathway; NRF2 pathway"	"MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase"	"7"	"0"	"162.7"	"110.0"	"165.7"	"235.3"	"286.6"	"234.2"	"1405.0"	"1323.4"	"944.7"	"1106.5"	"1187.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14011"	"Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1"	"27"	"3"	"6"	"3"	"172"	"18.6"	"9.51"	"746.21"	"17.86"	"2"	"3"	"cell organization and biogenesis;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"1153"	"ENSG00000099622"	"CIRBP"	"B3KT17; B4E2X2; hsa:1153; Q14011"	""	""	"0"	"0"	"277.6"	"194.3"	"253.1"	"251.2"	"293.9"	"254.9"	"727.5"	"676.7"	"541.2"	"653.9"	"747.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P33991"	"DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5"	"5"	"5"	"12"	"5"	"863"	"96.5"	"6.74"	"1962.43"	"17.82"	"5"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00493, Pf14551, Pf17207, Pf17855"	"4173"	"ENSG00000104738"	"MCM4"	"hsa:4173; P33991; Q8NEH1; Q99658"	"Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication"	"Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA"	"12"	"0"	"397.5"	"314.1"	"396.0"	"517.6"	"590.9"	"642.0"	"1039.4"	"982.8"	"580.9"	"822.2"	"1113.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46777"	"60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3"	"24"	"7"	"14"	"7"	"297"	"34.3"	"9.72"	"2930.79"	"17.74"	"7"	"6"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf14204, Pf17144"	"6125"	"ENSG00000122406"	"RPL5"	"hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"588.3"	"384.4"	"531.8"	"646.5"	"779.1"	"696.8"	"2893.5"	"2605.3"	"1980.2"	"2304.0"	"2713.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"E9PAV3"	"Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1"	"3"	"4"	"10"	"4"	"2078"	"205.3"	"9.58"	"1978.74"	"17.66"	"4"	"4"	"transport"	"translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01849, Pf19026"	""	"ENSG00000196531"	"NACA"	"E9PAV3"	""	""	"0"	"0"	"135.4"	"70.7"	"147.3"	"160.6"	"230.3"	"223.1"	"668.4"	"638.7"	"293.4"	"474.1"	"498.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4E8"	"Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3"	"7"	"6"	"11"	"6"	"981"	"112.3"	"5.22"	"1809.19"	"17.64"	"5"	"6"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00443, Pf06337, Pf14533, Pf14836"	"9958"	"ENSG00000135655"	"USP15"	"hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5"	""	"Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling"	"3"	"0"	"190.1"	"149.3"	"201.0"	"371.4"	"383.8"	"351.8"	"764.6"	"742.2"	"478.2"	"571.8"	"627.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25098"	"Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2"	"10"	"6"	"10"	"6"	"689"	"79.5"	"7.28"	"1559.26"	"17.63"	"5"	"5"	"cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"signal transduction activity or receptor binding;kinase activity;other molecular function"	"Pf00069, Pf00169, Pf00615"	"156"	"ENSG00000173020"	"GRK2"	"B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3"	"Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway"	"G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis; Calmodulin induced events"	"8"	"0"	"99.0"	"68.2"	"109.0"	"134.0"	"170.0"	"158.2"	"481.9"	"489.3"	"442.2"	"674.8"	"964.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H857"	"5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1"	"13"	"4"	"9"	"4"	"520"	"60.7"	"6.77"	"1245.15"	"17.60"	"3"	"4"	""	""	"other molecular function"	"Pf05761"	"64943"	"ENSG00000168268"	"NT5DC2"	"C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8"	""	""	"0"	"0"	"37.3"	"22.9"	"45.2"	"64.0"	"79.0"	"83.2"	"201.6"	"207.6"	"101.1"	"185.7"	"302.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62487"	"DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1"	"33"	"6"	"11"	"6"	"172"	"19.3"	"5.54"	"1657.05"	"17.59"	"5"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00575, Pf03876"	"5436"	"ENSG00000168002"	"POLR2G"	"B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4"	"Pyrimidine metabolism; Eukaryotic transcription initiation"	"mRNA Splicing - Major Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Minor Pathway; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"43"	"0"	"171.0"	"122.3"	"167.6"	"228.4"	"273.1"	"248.5"	"430.9"	"434.0"	"309.7"	"377.0"	"535.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16775"	"Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2"	"19"	"4"	"9"	"4"	"308"	"33.8"	"8.12"	"1668.67"	"17.59"	"3"	"4"	"other metabolic processes"	"cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00753, Pf16123"	"3029"	"ENSG00000063854"	"HAGH"	"A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775"	""	""	"0"	"0"	"73.9"	"55.1"	"62.5"	"73.3"	"109.4"	"98.8"	"160.4"	"164.2"	"128.7"	"117.5"	"216.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15056"	"Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5"	"27"	"5"	"11"	"5"	"248"	"27.4"	"7.23"	"2072.10"	"17.57"	"4"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"7458"	"ENSG00000106682"	"EIF4H"	"A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056"	"Translation factors; 7q11.23 copy number variation syndrome"	"L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition"	"7"	"0"	"286.6"	"240.0"	"301.6"	"418.8"	"479.7"	"480.5"	"943.7"	"1028.6"	"651.1"	"817.6"	"1175.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15446"	"DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=CD3EAP PE=1 SV=1"	"12"	"4"	"8"	"4"	"510"	"55.0"	"8.51"	"1790.39"	"17.50"	"4"	"4"	"RNA metabolism OR transcription;other metabolic processes;signal transduction"	"cytosol;mitochondrion;nucleus;other cell component"	""	"Pf08208"	"10849"	"ENSG00000117877"	"POLR1G"	"hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6"	"2q13 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination"	"6"	"0"	"76.2"	"52.7"	"91.2"	"133.2"	"150.9"	"136.0"	"345.4"	"522.1"	"517.0"	"752.7"	"984.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99873"	"Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3"	"18"	"6"	"11"	"6"	"371"	"42.4"	"5.35"	"1594.74"	"17.47"	"5"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf13649"	"3276"	"ENSG00000126457"	"PRMT1"	"A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06"	"Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways"	"Estrogen-dependent gene expression; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein"	"11"	"0"	"88.6"	"85.7"	"111.6"	"136.6"	"173.8"	"153.0"	"260.2"	"248.2"	"172.6"	"234.6"	"323.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96I24"	"Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2"	"12"	"7"	"13"	"4"	"572"	"61.6"	"8.38"	"1723.64"	"17.44"	"6"	"6"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"translational apparatus;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00013"	"8939"	"ENSG00000107164"	"FUBP3"	"A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6"	""	""	"0"	"1"	"267.3"	"182.8"	"228.9"	"289.7"	"433.1"	"359.0"	"842.9"	"882.5"	"392.6"	"661.6"	"885.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y606"	"tRNA pseudouridine synthase A OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3"	"17"	"6"	"9"	"6"	"427"	"47.4"	"8.41"	"1045.54"	"17.41"	"3"	"6"	"RNA metabolism OR transcription;other metabolic processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01416"	"80324"	"ENSG00000177192"	"PUS1"	"A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606"	""	""	"0"	"0"	"59.9"	"43.7"	"68.8"	"91.8"	"109.9"	"99.3"	"212.2"	"373.7"	"182.4"	"446.3"	"760.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46783"	"40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1"	"42"	"7"	"23"	"6"	"165"	"18.9"	"10.15"	"5825.27"	"17.39"	"7"	"4"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf03501"	"6204"	"ENSG00000124614"	"RPS10"	"B2R4E3; hsa:6204; P46783; Q5TZC0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"879.3"	"641.4"	"724.5"	"845.1"	"1004.8"	"913.2"	"3456.1"	"3181.3"	"2342.6"	"2343.8"	"2740.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96FN4"	"Copine-2 OS=Homo sapiens OX=9606 GN=CPNE2 PE=1 SV=3"	"9"	"4"	"10"	"3"	"548"	"61.2"	"6.07"	"1687.72"	"17.31"	"4"	"4"	"other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	"other molecular function"	"Pf00168, Pf07002"	"221184"	"ENSG00000140848"	"CPNE2"	"hsa:221184; Q68D19; Q719H8; Q86XP9; Q96FN4"	""	""	"0"	"0"	"115.5"	"107.4"	"119.9"	"134.7"	"154.8"	"169.2"	"252.0"	"266.6"	"205.8"	"226.7"	"349.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43809"	"Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1"	"24"	"6"	"14"	"6"	"227"	"26.2"	"8.82"	"2337.96"	"17.25"	"6"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf13869"	"11051"	"ENSG00000167005"	"NUDT21"	"hsa:11051; O43809; Q6IB85; Q6NE84"	"mRNA processing"	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs"	"5"	"0"	"630.0"	"444.8"	"585.8"	"700.6"	"917.6"	"821.8"	"2292.8"	"1982.0"	"1286.4"	"1632.7"	"2139.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62857"	"40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1"	"41"	"4"	"11"	"4"	"69"	"7.8"	"10.70"	"2716.29"	"17.23"	"4"	"4"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01200"	"6234"	"ENSG00000233927"	"RPS28"	"hsa:6234; P25112; P62857"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery"	"19"	"0"	"337.2"	"262.9"	"316.7"	"361.9"	"430.1"	"396.0"	"1683.3"	"1480.6"	"1023.9"	"1132.2"	"1189.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q09161"	"Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1"	"10"	"5"	"8"	"5"	"790"	"91.8"	"6.43"	"1146.68"	"17.16"	"3"	"5"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02854, Pf09088, Pf09090"	"4686"	"ENSG00000136937"	"NCBP1"	"B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2"	"mRNA processing; 3q29 copy number variation syndrome"	"Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"	"29"	"0"	"228.8"	"138.4"	"220.0"	"287.6"	"352.4"	"294.4"	"924.8"	"897.8"	"563.8"	"827.3"	"928.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35611"	"Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2"	"11"	"6"	"11"	"6"	"737"	"80.9"	"5.83"	"2289.70"	"17.08"	"6"	"5"	"cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00596"	"118"	"ENSG00000087274"	"ADD1"	"A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6"	""	"XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events"	"3"	"0"	"197.3"	"128.7"	"185.7"	"269.9"	"338.3"	"278.0"	"734.7"	"678.1"	"399.1"	"589.7"	"745.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NCB2"	"CaM kinase-like vesicle-associated protein OS=Homo sapiens OX=9606 GN=CAMKV PE=2 SV=2"	"9"	"4"	"10"	"4"	"501"	"54.3"	"5.55"	"2097.97"	"17.05"	"4"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;other membranes;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"79012"	"ENSG00000164076"	"CAMKV"	"A6NFD4; hsa:79012; Q6FIB8; Q8NBS8; Q8NC85; Q8NCB2; Q8NDU4; Q8WTT8; Q9BQC9; Q9H0Q5"	""	""	"0"	"0"	"21.6"	"13.0"	"15.9"	"24.0"	"23.1"	"21.8"	"83.6"	"148.6"	"315.4"	"538.0"	"514.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46063"	"ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3"	"9"	"4"	"12"	"4"	"649"	"73.4"	"7.88"	"1793.22"	"16.94"	"4"	"4"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf16124"	"5965"	"ENSG00000004700"	"RECQL"	"A8K6G2; hsa:5965; P46063"	"Progeria-associated lipodystrophy"	""	"1"	"0"	"13.7"	"8.9"	"11.7"	"11.8"	"21.3"	"14.2"	"93.4"	"88.6"	"48.8"	"66.7"	"63.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRG1"	"Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1"	"43"	"7"	"12"	"7"	"176"	"20.7"	"6.34"	"2804.21"	"16.91"	"7"	"5"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf05871"	"84313"	"ENSG00000131475"	"VPS25"	"B2R581; hsa:84313; Q9BRG1"	""	"Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events"	"2"	"0"	"83.1"	"55.6"	"89.6"	"121.2"	"151.0"	"131.8"	"348.6"	"510.6"	"495.5"	"799.7"	"1890.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51610"	"Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2"	"4"	"7"	"11"	"7"	"2035"	"208.6"	"7.46"	"2098.89"	"16.80"	"6"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf01344, Pf13415"	"3054"	"ENSG00000172534"	"HCFC1"	"hsa:3054; P51610; Q6P4G5"	"Mitochondrial gene expression; Pleural mesothelioma"	"UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones"	"6"	"0"	"201.2"	"120.3"	"201.5"	"252.7"	"319.8"	"268.6"	"721.8"	"733.9"	"461.2"	"569.3"	"773.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92747"	"Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=2 SV=2"	"16"	"4"	"7"	"3"	"370"	"41.5"	"8.18"	"1234.25"	"16.70"	"3"	"4"	"cell organization and biogenesis"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity"	"Pf00400"	"10552"	"ENSG00000241685"	"ARPC1A"	"A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747"	"Pathogenic Escherichia coli infection"	"Clathrin-mediated endocytosis; FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs"	"6"	"1"	"98.0"	"66.3"	"105.8"	"124.1"	"162.9"	"159.8"	"430.3"	"628.9"	"454.6"	"845.5"	"2268.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35606"	"Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2"	"7"	"5"	"10"	"5"	"906"	"102.4"	"5.27"	"2212.78"	"16.69"	"4"	"4"	"transport"	"other membranes;cytosol;ER/Golgi"	"other molecular function"	"Pf00400, Pf04053"	"9276"	"ENSG00000184432"	"COPB2"	"B4DZI8; hsa:9276; P35606"	""	"COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport"	"2"	"0"	"159.6"	"118.1"	"183.2"	"242.5"	"302.6"	"258.0"	"546.3"	"546.4"	"352.4"	"461.4"	"508.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y285"	"Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3"	"8"	"5"	"10"	"5"	"508"	"57.5"	"7.80"	"1749.66"	"16.63"	"5"	"5"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01409, Pf18552, Pf18553, Pf18554"	"2193"	"ENSG00000179115"	"FARSA"	"B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8"	""	"Cytosolic tRNA aminoacylation"	"1"	"0"	"204.0"	"147.2"	"202.5"	"238.1"	"277.0"	"243.0"	"1060.0"	"1025.6"	"750.8"	"931.5"	"1165.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04899"	"Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3"	"15"	"5"	"11"	"1"	"355"	"40.4"	"5.54"	"1605.70"	"16.62"	"4"	"5"	"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00503"	"2771"	"ENSG00000114353"	"GNAI2"	"B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71"	"Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway"	"G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion"	"22"	"0"	"24.4"	"17.2"	"18.5"	"27.7"	"37.9"	"29.9"	"65.7"	"59.1"	"49.0"	"59.2"	"81.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05141"	"ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7"	"15"	"4"	"9"	"2"	"298"	"32.8"	"9.69"	"1631.21"	"16.59"	"3"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;cytoskeleton;mitochondrion"	"transporter activity;other molecular function"	"Pf00153"	"292"	"ENSG00000005022"	"SLC25A5"	"B2RCV1; hsa:292; O43350; P05141"	"Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization"	"5"	"2"	"343.7"	"204.7"	"288.7"	"388.5"	"500.9"	"387.8"	"774.5"	"693.2"	"401.2"	"600.6"	"831.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49189"	"4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3"	"14"	"7"	"8"	"7"	"494"	"53.8"	"5.87"	"610.53"	"16.59"	"2"	"6"	"cell organization and biogenesis;other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf00171"	"223"	"ENSG00000143149"	"ALDH9A1"	"B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7"	"GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways"	"Carnitine synthesis"	"4"	"0"	"274.1"	"203.8"	"269.1"	"524.9"	"577.6"	"561.8"	"915.8"	"848.2"	"620.2"	"697.7"	"1046.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P013"	"Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2"	"19"	"3"	"6"	"3"	"229"	"26.6"	"5.71"	"772.70"	"16.56"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity"	"Pf04889"	"51503"	"ENSG00000150316"	"CWC15"	"B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"175.3"	"83.1"	"151.0"	"181.2"	"245.6"	"200.6"	"698.8"	"597.0"	"384.3"	"510.8"	"691.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00303"	"Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1"	"18"	"6"	"12"	"6"	"357"	"37.5"	"5.45"	"1901.61"	"16.53"	"6"	"6"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01398, Pf13012"	"8665"	"ENSG00000175390"	"EIF3F"	"A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978"	"Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"9"	"0"	"272.4"	"219.6"	"259.1"	"302.8"	"383.1"	"364.5"	"632.8"	"620.8"	"441.2"	"508.2"	"712.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P2T1"	"GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1"	"12"	"4"	"7"	"4"	"348"	"37.9"	"7.23"	"662.42"	"16.50"	"1"	"4"	"other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf00478"	"51292"	"ENSG00000100938; ENSG00000284752"	"GMPR2"	"D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1"	""	"Purine salvage"	"1"	"0"	"102.2"	"69.1"	"95.0"	"132.8"	"171.5"	"196.1"	"384.8"	"564.1"	"1524.7"	"3687.2"	"5069.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P57076"	"Cilia- and flagella-associated protein 298 OS=Homo sapiens OX=9606 GN=CFAP298 PE=1 SV=1"	"21"	"4"	"8"	"4"	"290"	"33.2"	"7.44"	"1537.08"	"16.50"	"3"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytoskeleton;other cell component"	""	"Pf11069"	"56683"	"ENSG00000159079"	"CFAP298"	"hsa:56683; P57076; Q53FH0"	"Ciliopathies"	""	"1"	"0"	"105.8"	"61.5"	"116.9"	"211.6"	"259.1"	"224.8"	"663.8"	"649.7"	"459.4"	"530.8"	"802.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P40222"	"Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3"	"10"	"5"	"9"	"4"	"546"	"61.9"	"6.52"	"1985.75"	"16.45"	"5"	"4"	"transport;other biological processes"	"non-structural extracellular;cytosol;other cell component"	"other molecular function"	"Pf09728"	"200081"	"ENSG00000084652"	"TXLNA"	"D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3"	""	"Other interleukin signaling"	"1"	"1"	"49.9"	"29.4"	"55.2"	"56.2"	"75.0"	"76.4"	"452.1"	"450.5"	"304.4"	"402.3"	"653.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63208"	"S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2"	"35"	"5"	"10"	"5"	"163"	"18.6"	"4.54"	"1970.48"	"16.43"	"5"	"5"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf01466, Pf03931"	"6500"	"ENSG00000113558"	"SKP1"	"D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2"	"Cell cycle; TNF-alpha signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway"	"Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling"	"38"	"0"	"319.3"	"219.2"	"309.6"	"470.7"	"512.2"	"456.9"	"1066.4"	"1029.8"	"622.0"	"810.6"	"996.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62917"	"60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2"	"22"	"6"	"10"	"6"	"257"	"28.0"	"11.03"	"1689.31"	"16.41"	"5"	"5"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00181, Pf03947"	"6132"	"ENSG00000161016"	"RPL8"	"A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"378.4"	"304.6"	"351.9"	"421.7"	"562.9"	"471.6"	"2179.5"	"1900.3"	"1365.7"	"1604.1"	"1762.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P02768"	"Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2"	"12"	"7"	"12"	"7"	"609"	"69.3"	"6.28"	"3168.17"	"16.36"	"6"	"5"	"stress response;other biological processes"	"non-structural extracellular;ER/Golgi;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00273"	"213"	"ENSG00000163631"	"ALB"	"E7ESS9; hsa:213; O95574; P02768; P04277; Q13140; Q645G4; Q68DN5; Q6UXK4; Q86YG0; Q8IUK7; Q9P157; Q9P1I7; Q9UHS3; Q9UJZ0"	"Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling"	"Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cytoprotection by HMOX1; Aspirin ADME; Ciprofloxacin ADME; Recycling of bile acids and salts; Prednisone ADME; Heme degradation; HDL remodeling; Heme biosynthesis"	"17"	"0"	"111.7"	"61.7"	"79.4"	"126.2"	"143.5"	"140.1"	"807.3"	"866.3"	"628.5"	"730.3"	"882.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12814"	"Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2"	"8"	"5"	"10"	"2"	"892"	"103.0"	"5.41"	"1825.86"	"16.36"	"5"	"5"	"cell adhesion;cell organization and biogenesis;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00307, Pf00435, Pf08726"	"87"	"ENSG00000072110"	"ACTN1"	"B3V8S3; B4DHH3; B7TY16; hsa:87; P12814; Q1HE25; Q9BTN1"	"Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Ebola virus infection in host; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Regulation of actin cytoskeleton"	"RHOD GTPase cycle; RHOF GTPase cycle; Platelet degranulation ; Nephrin family interactions; Syndecan interactions; RHOBTB2 GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"	"12"	"3"	"155.0"	"138.5"	"158.6"	"173.2"	"233.4"	"266.9"	"438.3"	"422.5"	"265.6"	"402.0"	"700.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95400"	"CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1"	"28"	"7"	"11"	"7"	"341"	"37.6"	"4.61"	"2536.30"	"16.35"	"6"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf02213"	"10421"	"ENSG00000169217"	"CD2BP2"	"B2RDX2; hsa:10421; O95400; Q9ULP2"	"mRNA processing; Ciliary landscape"	""	"2"	"0"	"226.1"	"154.1"	"224.8"	"240.8"	"322.3"	"278.4"	"741.6"	"793.5"	"601.0"	"689.9"	"864.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09496"	"Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1"	"20"	"6"	"12"	"6"	"248"	"27.1"	"4.51"	"1699.98"	"16.29"	"6"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf01086"	"1211"	"ENSG00000122705"	"CLTA"	"A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1"	"Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome"	"MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Recycling pathway of L1; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions"	"17"	"0"	"831.1"	"642.0"	"977.8"	"1303.5"	"1338.3"	"1245.9"	"1973.9"	"1801.4"	"1176.7"	"1435.5"	"1832.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26196"	"Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2"	"12"	"5"	"10"	"5"	"483"	"54.4"	"8.66"	"2067.89"	"16.27"	"4"	"4"	"cell organization and biogenesis;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"1656"	"ENSG00000110367"	"DDX6"	"hsa:1656; P26196; Q5D048"	""	"mRNA decay by 5' to 3' exoribonuclease"	"1"	"0"	"90.3"	"53.0"	"85.5"	"109.9"	"161.3"	"124.1"	"642.9"	"670.3"	"413.6"	"550.3"	"698.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49006"	"MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2"	"28"	"3"	"7"	"3"	"195"	"19.5"	"4.67"	"876.54"	"16.27"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf02063"	"65108"	"ENSG00000175130"	"MARCKSL1"	"D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5"	""	""	"0"	"0"	"284.2"	"209.1"	"243.4"	"317.7"	"414.2"	"418.7"	"730.9"	"688.5"	"438.1"	"686.6"	"1057.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55769"	"NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3"	"32"	"4"	"7"	"4"	"128"	"14.2"	"8.46"	"925.99"	"16.19"	"3"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01248"	"4809"	"ENSG00000100138"	"SNU13"	"hsa:4809; P55769"	"mRNA processing"	"mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"4"	"0"	"115.9"	"92.9"	"130.6"	"156.9"	"185.8"	"164.1"	"477.9"	"483.1"	"429.1"	"650.1"	"1158.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14314"	"Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2"	"15"	"8"	"12"	"8"	"528"	"59.4"	"4.41"	"1824.75"	"16.16"	"6"	"6"	"protein metabolism;other metabolic processes;developmental processes;signal transduction"	"ER/Golgi;other cell component"	"other molecular function"	"Pf12999, Pf13015, Pf13202"	"5589"	"ENSG00000130175"	"PRKCSH"	"A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9"	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein"	"7"	"0"	"464.0"	"320.3"	"604.4"	"849.6"	"960.0"	"941.7"	"1890.9"	"1873.0"	"1118.7"	"1378.9"	"2002.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11387"	"DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2"	"10"	"5"	"7"	"5"	"765"	"90.7"	"9.31"	"533.40"	"16.15"	"2"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf01028, Pf02919, Pf14370"	"7150"	"ENSG00000198900"	"TOP1"	"A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0"	"Ebola virus infection in host; 15q25 copy number variation"	"SUMOylation of DNA replication proteins"	"3"	"0"	"64.7"	"28.4"	"60.1"	"57.4"	"70.7"	"66.4"	"210.1"	"270.4"	"256.2"	"446.6"	"929.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVP1"	"ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2"	"6"	"3"	"4"	"3"	"670"	"75.4"	"9.50"	"245.55"	"16.13"	"1"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"other molecular function"	"Pf00270, Pf00271, Pf13959"	"8886"	"ENSG00000088205"	"DDX18"	"hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1"	""	""	"0"	"0"	"10.5"	"4.4"	"13.1"	"17.9"	"13.1"	"12.5"	"59.3"	"67.2"	"54.5"	"82.6"	"106.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IY18"	"Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2"	"6"	"5"	"10"	"5"	"1101"	"128.7"	"8.38"	"1617.85"	"16.11"	"5"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02463"	"23137"	"ENSG00000198887"	"SMC5"	"A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9"	""	"SUMOylation of DNA damage response and repair proteins"	"1"	"0"	"19.7"	"12.2"	"31.3"	"31.2"	"37.9"	"33.1"	"129.6"	"116.7"	"84.3"	"116.3"	"189.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13595"	"Transformer-2 protein homolog alpha OS=Homo sapiens OX=9606 GN=TRA2A PE=1 SV=1"	"13"	"5"	"11"	"5"	"282"	"32.7"	"11.27"	"1666.28"	"16.11"	"4"	"5"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf00076"	"29896"	"ENSG00000164548"	"TRA2A"	"B4DQI6; B4DUA9; E9PD75; hsa:29896; Q13595"	"Orexin receptor pathway"	""	"1"	"0"	"332.7"	"238.0"	"278.5"	"360.9"	"458.3"	"395.0"	"1090.3"	"1014.5"	"1098.8"	"2727.5"	"3625.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62266"	"40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3"	"17"	"3"	"9"	"3"	"143"	"15.8"	"10.49"	"1532.79"	"16.07"	"2"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf00164"	"6228"	"ENSG00000186468"	"RPS23"	"hsa:6228; P39028; P62266; Q6IB08"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"415.1"	"298.9"	"466.9"	"473.1"	"589.1"	"534.0"	"1890.1"	"1749.0"	"1193.2"	"1411.0"	"1633.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P38606"	"V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2"	"10"	"4"	"8"	"4"	"617"	"68.3"	"5.52"	"1150.58"	"16.02"	"2"	"4"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"transporter activity;other molecular function"	"Pf00006, Pf02874, Pf16886"	"523"	"ENSG00000114573"	"ATP6V1A"	"B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3"	"Proximal tubule transport"	"Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport"	"6"	"0"	"58.4"	"49.4"	"64.2"	"84.8"	"122.6"	"99.4"	"216.9"	"205.8"	"126.8"	"161.2"	"255.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14561"	"Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3"	"13"	"3"	"7"	"3"	"156"	"17.4"	"4.93"	"1829.99"	"15.93"	"3"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"other membranes;cytosol;mitochondrion;nucleus"	"translation activity;other molecular function"	"Pf00550"	"4706"	"ENSG00000004779"	"NDUFAB1"	"B2R4M1; hsa:4706; O14561; Q9UNV1"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis"	"7"	"0"	"185.5"	"143.8"	"158.2"	"242.0"	"292.1"	"296.9"	"455.7"	"521.9"	"450.9"	"636.0"	"1516.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P84090"	"Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1"	"34"	"3"	"8"	"3"	"104"	"12.3"	"5.92"	"799.14"	"15.89"	"2"	"3"	"cell cycle OR cell proliferation;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf01133"	"2079"	"ENSG00000100632"	"ERH"	"B2R5H2; hsa:2079; P70659; P84090; Q14259"	""	""	"0"	"0"	"315.9"	"282.7"	"300.5"	"367.5"	"430.7"	"436.1"	"844.0"	"762.6"	"780.8"	"978.8"	"1024.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14644"	"Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3"	"6"	"6"	"12"	"6"	"834"	"95.6"	"7.15"	"1829.37"	"15.87"	"6"	"6"	"transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol"	"transporter activity;enzyme regulator activity;other molecular function"	"Pf00168, Pf00169, Pf00616, Pf00779"	"22821"	"ENSG00000185989; ENSG00000280477"	"RASA3"	"A6NL15; F8W6X8; hsa:22821; Q14644; Q8IUY2"	"MAPK cascade; Ras signaling; IL-18 signaling pathway"	"Regulation of RAS by GAPs"	"4"	"0"	"226.6"	"185.6"	"261.3"	"326.0"	"361.2"	"537.1"	"1394.9"	"1189.3"	"811.7"	"1323.2"	"1849.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P43490"	"Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1"	"13"	"5"	"9"	"5"	"491"	"55.5"	"7.15"	"1290.96"	"15.83"	"3"	"5"	"cell-cell signaling;other metabolic processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf04095, Pf18127"	"10135"	"ENSG00000105835"	"NAMPT"	"A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95"	"Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence"	"NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging"	"9"	"0"	"204.7"	"133.2"	"247.1"	"460.3"	"528.8"	"366.2"	"893.6"	"851.7"	"521.0"	"640.6"	"664.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P34896"	"Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1"	"8"	"3"	"8"	"2"	"483"	"53.0"	"7.71"	"1386.44"	"15.83"	"3"	"3"	"cell organization and biogenesis;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00464"	"6470"	"ENSG00000176974; ENSG00000284320"	"SHMT1"	"B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2"	"Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation"	"Metabolism of folate and pterines; Carnitine synthesis"	"11"	"0"	"32.5"	"21.4"	"36.5"	"38.5"	"45.0"	"44.9"	"86.0"	"77.7"	"54.3"	"65.6"	"103.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15691"	"Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3"	"28"	"6"	"8"	"6"	"268"	"30.0"	"5.14"	"1177.98"	"15.73"	"3"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf03271"	"22919"	"ENSG00000101367"	"MAPRE1"	"B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8"	"Microtubule cytoskeleton regulation"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; The role of GTSE1 in G2/M progression after G2 checkpoint; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"15"	"0"	"217.4"	"169.3"	"242.9"	"284.0"	"345.1"	"336.1"	"681.6"	"711.3"	"541.0"	"664.3"	"896.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09493"	"Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2"	"18"	"5"	"13"	"1"	"284"	"32.7"	"4.74"	"2481.25"	"15.66"	"5"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00261"	"7168"	"ENSG00000140416"	"TPM1"	"B7Z5T7; D9YZV2; D9YZV3; D9YZV8; hsa:7168; P09493; P09494; P10469; Q6DV89; Q6DV90; Q7Z6L8; Q86W64; Q96IK2; Q9UCI1; Q9UCI2; Q9UCY9; Q9Y427"	"Vitamin D receptor pathway; Striated muscle contraction pathway"	"Smooth Muscle Contraction; Striated Muscle Contraction"	"4"	"0"	"8.5"	"7.1"	"6.9"	"7.1"	"12.3"	"7.2"	"22.8"	"21.3"	"18.1"	"23.0"	"24.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86U42"	"Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3"	"19"	"5"	"10"	"5"	"306"	"32.7"	"5.06"	"1600.48"	"15.65"	"4"	"4"	"RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"8106"	"ENSG00000100836"	"PABPN1"	"D3DS49; hsa:8106; O43484; Q86U42"	"mRNA processing"	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing"	"6"	"0"	"627.8"	"368.1"	"615.0"	"915.6"	"1077.2"	"938.2"	"1612.5"	"1274.7"	"729.7"	"1142.5"	"2004.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94842"	"TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1"	"9"	"4"	"7"	"4"	"621"	"66.2"	"5.06"	"1038.83"	"15.63"	"3"	"4"	"other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00505"	"9878"	"ENSG00000092203"	"TOX4"	"B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842"	""	""	"0"	"0"	"53.5"	"39.7"	"56.1"	"86.8"	"93.9"	"88.5"	"243.4"	"217.1"	"153.9"	"176.6"	"250.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16352"	"Alpha-internexin OS=Homo sapiens OX=9606 GN=INA PE=1 SV=2"	"11"	"6"	"13"	"4"	"499"	"55.4"	"5.40"	"2360.26"	"15.57"	"6"	"5"	"cell organization and biogenesis;other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf00038, Pf04732"	"9118"	"ENSG00000148798"	"INA"	"B1AQK0; hsa:9118; Q16352; Q9BRC5"	""	""	"0"	"0"	"231.3"	"139.9"	"227.3"	"341.3"	"455.3"	"354.8"	"522.9"	"488.3"	"275.9"	"428.9"	"637.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13123"	"Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3"	"12"	"7"	"12"	"7"	"557"	"65.6"	"6.64"	"2437.35"	"15.43"	"7"	"5"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf07807, Pf07808"	"3550"	"ENSG00000113141"	"IK"	"hsa:3550; Q13123; Q6IPD8"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"207.8"	"120.0"	"178.2"	"244.1"	"344.4"	"308.2"	"987.2"	"974.9"	"599.6"	"848.6"	"1228.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKA9"	"Polypyrimidine tract-binding protein 2 OS=Homo sapiens OX=9606 GN=PTBP2 PE=1 SV=1"	"8"	"4"	"11"	"2"	"531"	"57.5"	"8.66"	"1674.98"	"15.41"	"3"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf11835, Pf13893"	"58155"	"ENSG00000117569"	"PTBP2"	"hsa:58155; Q8N0Z1; Q8N160; Q8NFB0; Q8NFB1; Q969N9; Q96Q76; Q9UKA9"	"Genes targeted by miRNAs in adipocytes; mRNA processing"	""	"2"	"0"	"103.7"	"66.7"	"95.4"	"159.0"	"191.9"	"164.1"	"485.5"	"437.4"	"294.6"	"354.5"	"502.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92917"	"G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2"	"11"	"4"	"8"	"4"	"476"	"52.2"	"6.15"	"1498.62"	"15.40"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf00467, Pf12656"	"27238"	"ENSG00000068394"	"GPKOW"	"hsa:27238; Q59EK5; Q92917; Q9BQA8"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"51.6"	"39.7"	"70.3"	"79.3"	"94.2"	"85.5"	"192.8"	"199.6"	"125.2"	"209.5"	"295.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25398"	"40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3"	"42"	"5"	"9"	"5"	"132"	"14.5"	"7.21"	"1170.14"	"15.34"	"3"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01248"	"6206"	"ENSG00000112306"	"RPS12"	"hsa:6206; P25398; Q76M58"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"197.6"	"171.2"	"212.9"	"273.6"	"327.6"	"281.3"	"663.7"	"658.7"	"476.1"	"565.3"	"607.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63096"	"Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Homo sapiens OX=9606 GN=GNAI1 PE=1 SV=2"	"14"	"5"	"11"	"1"	"354"	"40.3"	"5.97"	"1491.95"	"15.33"	"4"	"5"	"cell cycle OR cell proliferation;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00503"	"2770"	"ENSG00000127955"	"GNAI1"	"A8KA88; B4E2V1; C9J3A4; hsa:2770; P04898; P11015; P31871; P63096; Q5U074; Q8TAN5; Q9UGA4"	"Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Chemokine signaling pathway; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway"	"G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion"	"25"	"1"	"41.6"	"24.9"	"44.7"	"34.9"	"54.4"	"43.6"	"144.3"	"139.5"	"101.6"	"128.7"	"159.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19784"	"Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1"	"15"	"5"	"10"	"4"	"350"	"41.2"	"8.56"	"1567.30"	"15.28"	"5"	"5"	"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"1459"	"ENSG00000070770"	"CSNK2A2"	"hsa:1459; P19784"	"Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease"	"Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC"	"19"	"0"	"88.9"	"76.1"	"106.4"	"121.5"	"147.1"	"147.9"	"607.3"	"562.0"	"538.7"	"669.3"	"683.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75400"	"Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2"	"6"	"6"	"11"	"6"	"957"	"108.7"	"7.56"	"1910.85"	"15.19"	"6"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	""	"Pf00397, Pf01846"	"55660"	"ENSG00000196504"	"PRPF40A"	"hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"311.4"	"181.9"	"291.2"	"376.8"	"495.9"	"442.7"	"1143.6"	"1139.3"	"783.0"	"1229.3"	"1630.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P53621"	"Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2"	"4"	"6"	"10"	"6"	"1224"	"138.3"	"7.66"	"1286.40"	"15.15"	"4"	"6"	"transport;signal transduction"	"non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00400, Pf04053, Pf06957, Pf12894"	"1314"	"ENSG00000122218"	"COPA"	"hsa:1314; P53621; Q5T201; Q8IXZ9"	""	"COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport"	"2"	"0"	"199.1"	"145.5"	"210.7"	"258.3"	"372.7"	"316.4"	"896.5"	"893.9"	"493.9"	"708.2"	"907.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18583"	"Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4"	"2"	"5"	"11"	"5"	"2426"	"263.7"	"5.64"	"1861.55"	"15.09"	"5"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf01585, Pf14709, Pf17069"	"6651"	"ENSG00000159140"	"SON"	"D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0"	""	""	"0"	"0"	"415.1"	"254.0"	"348.8"	"423.7"	"567.9"	"485.8"	"1200.2"	"962.5"	"587.3"	"936.3"	"1194.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15344"	"E3 ubiquitin-protein ligase Midline-1 OS=Homo sapiens OX=9606 GN=MID1 PE=1 SV=1"	"8"	"5"	"8"	"5"	"667"	"75.2"	"6.80"	"983.37"	"15.07"	"3"	"5"	"cell organization and biogenesis;developmental processes;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00041, Pf00622, Pf00643, Pf13445, Pf13765, Pf18568"	"4281"	"ENSG00000101871"	"MID1"	"B2RCG2; hsa:4281; O15344; O75361; Q9BZX5"	""	"Interferon gamma signaling"	"1"	"0"	"90.1"	"52.7"	"84.4"	"118.0"	"155.5"	"137.6"	"484.2"	"652.4"	"486.0"	"716.0"	"907.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12972"	"Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2"	"16"	"3"	"4"	"3"	"351"	"38.5"	"7.37"	"477.89"	"15.06"	"1"	"3"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00498"	"5511"	"ENSG00000117751"	"PPP1R8"	"hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"97.8"	"53.9"	"114.8"	"120.1"	"153.9"	"159.5"	"342.7"	"327.8"	"231.3"	"290.7"	"408.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14744"	"Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4"	"11"	"5"	"8"	"5"	"637"	"72.6"	"6.29"	"1053.29"	"15.03"	"3"	"5"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf05185, Pf17285, Pf17286"	"10419"	"ENSG00000100462"	"PRMT5"	"A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1"	"Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis"	"snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation"	"5"	"0"	"298.0"	"215.2"	"282.8"	"360.4"	"448.2"	"413.6"	"756.9"	"763.1"	"495.0"	"714.7"	"976.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P42167"	"Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2"	"14"	"6"	"11"	"6"	"454"	"50.6"	"9.38"	"2185.36"	"15.03"	"6"	"5"	""	"other membranes;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03020, Pf08198"	"7112"	"ENSG00000120802"	"TMPO"	"A2T926; hsa:7112; P42167; Q14861"	"Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies"	"RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle"	"12"	"0"	"403.8"	"261.5"	"373.5"	"458.8"	"604.9"	"511.6"	"1328.0"	"1194.9"	"599.1"	"957.8"	"1277.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60832"	"H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3"	"5"	"2"	"6"	"2"	"514"	"57.6"	"9.42"	"1736.22"	"15.03"	"2"	"2"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01472, Pf01509, Pf08068, Pf16198"	"1736"	"ENSG00000130826"	"DKC1"	"F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505"	""	"rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase"	"2"	"0"	"79.2"	"55.0"	"85.6"	"95.6"	"146.1"	"117.7"	"411.0"	"444.2"	"270.7"	"352.5"	"491.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14157"	"Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2"	"5"	"5"	"9"	"5"	"1087"	"114.5"	"7.11"	"1313.11"	"14.98"	"4"	"5"	"cell organization and biogenesis;other biological processes"	"nucleus;other cell component"	""	"Pf12478"	"9898"	"ENSG00000143569"	"UBAP2L"	"B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"279.6"	"170.1"	"278.2"	"373.2"	"474.2"	"424.8"	"1155.3"	"1125.6"	"751.6"	"997.4"	"1317.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P00492"	"Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2"	"32"	"6"	"12"	"6"	"218"	"24.6"	"6.68"	"1872.32"	"14.96"	"6"	"6"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00156"	"3251"	"ENSG00000165704"	"HPRT1"	"A6NHF0; B2R8M9; hsa:3251; P00492"	"Mesodermal commitment pathway"	"Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage"	"4"	"0"	"197.8"	"149.0"	"206.3"	"231.0"	"294.0"	"289.3"	"494.2"	"438.9"	"273.9"	"402.3"	"666.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00505"	"Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2"	"13"	"5"	"9"	"5"	"521"	"57.8"	"4.94"	"1900.73"	"14.94"	"4"	"4"	"cell organization and biogenesis;transport;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00514, Pf01749, Pf16186"	"3839"	"ENSG00000102753"	"KPNA3"	"hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7"	""	"ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways"	"2"	"0"	"336.9"	"210.1"	"300.8"	"438.9"	"539.0"	"470.7"	"838.0"	"834.7"	"520.5"	"624.6"	"875.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13011"	"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2"	"12"	"4"	"8"	"4"	"328"	"35.8"	"8.00"	"1057.47"	"14.93"	"3"	"4"	"other metabolic processes"	"cytosol;mitochondrion;other cytoplasmic organelle"	"other molecular function"	"Pf00378"	"1891"	"ENSG00000104823; ENSG00000282853"	"ECH1"	"A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9"	"Fatty acid biosynthesis; IL-18 signaling pathway"	"Peroxisomal protein import"	"3"	"0"	"213.7"	"143.8"	"210.0"	"278.2"	"351.2"	"319.9"	"842.0"	"884.4"	"621.5"	"971.8"	"1507.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H4G0"	"Band 4.1-like protein 1 OS=Homo sapiens OX=9606 GN=EPB41L1 PE=1 SV=2"	"8"	"5"	"8"	"5"	"881"	"98.4"	"5.62"	"1719.59"	"14.91"	"4"	"4"	"cell organization and biogenesis"	"plasma membrane;other membranes;cytosol;cytoskeleton"	"cytoskeletal activity;other molecular function"	"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380"	"2036"	"ENSG00000088367"	"EPB41L1"	"hsa:2036; O15046; Q4VXM6; Q4VXM7; Q4VXM8; Q4VXN4; Q6ZT61; Q8IUU7; Q96CV5; Q96L65; Q9H4G0"	"Splicing factor NOVA regulated synaptic proteins"	"Trafficking of AMPA receptors; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Neurexins and neuroligins"	"5"	"0"	"83.0"	"44.7"	"65.3"	"112.9"	"111.7"	"102.5"	"476.2"	"475.0"	"370.4"	"623.4"	"799.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NPJ3"	"Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1"	"25"	"3"	"8"	"3"	"140"	"15.0"	"9.14"	"1578.03"	"14.89"	"3"	"3"	"cell organization and biogenesis;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;mitochondrion"	"other molecular function"	"Pf03061"	"55856"	"ENSG00000112304"	"ACOT13"	"F5H2L4; hsa:55856; O95549; Q9NPJ3"	""	"Mitochondrial Fatty Acid Beta-Oxidation"	"1"	"0"	"114.5"	"65.4"	"99.3"	"129.1"	"184.7"	"142.3"	"464.0"	"475.4"	"391.0"	"495.8"	"1319.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P16949"	"Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3"	"29"	"4"	"8"	"4"	"149"	"17.3"	"5.97"	"1525.29"	"14.78"	"4"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf00836"	"3925"	"ENSG00000117632"	"STMN1"	"A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949"	"Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway"	"Nuclear signaling by ERBB4"	"7"	"0"	"185.9"	"128.1"	"202.9"	"292.0"	"377.0"	"360.1"	"649.2"	"683.5"	"368.5"	"602.9"	"985.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25788"	"Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2"	"15"	"4"	"10"	"4"	"255"	"28.4"	"5.33"	"1872.75"	"14.75"	"4"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00227, Pf10584"	"5684"	"ENSG00000100567"	"PSMA3"	"B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis"	"62"	"0"	"233.1"	"178.8"	"231.8"	"305.5"	"399.6"	"354.4"	"1092.6"	"1085.7"	"696.6"	"755.7"	"974.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96F07"	"Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2"	"4"	"5"	"10"	"2"	"1278"	"148.3"	"7.31"	"1543.14"	"14.73"	"5"	"5"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf05994, Pf07159"	"26999"	"ENSG00000055163"	"CYFIP2"	"A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29"	"Fragile X syndrome; Regulation of actin cytoskeleton"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway"	"7"	"2"	"52.6"	"25.5"	"49.2"	"57.4"	"82.6"	"60.4"	"251.7"	"246.6"	"191.1"	"252.5"	"348.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25786"	"Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1"	"25"	"5"	"8"	"5"	"263"	"29.5"	"6.61"	"1360.15"	"14.56"	"4"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00227, Pf10584"	"5682"	"ENSG00000129084"	"PSMA1"	"A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"ER-Phagosome pathway; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"251.9"	"176.6"	"229.7"	"320.1"	"370.8"	"361.1"	"989.1"	"989.3"	"662.1"	"781.9"	"1166.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78527"	"DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3"	"1"	"4"	"9"	"4"	"4128"	"468.8"	"7.12"	"1337.29"	"14.51"	"3"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502"	"5591"	"ENSG00000253729"	"PRKDC"	"hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3"	"miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response"	"E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN"	"14"	"0"	"200.4"	"134.6"	"145.1"	"196.8"	"248.1"	"214.4"	"390.7"	"372.6"	"215.5"	"345.3"	"396.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60660"	"Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2"	"32"	"4"	"8"	"4"	"151"	"16.9"	"4.65"	"1452.20"	"14.47"	"4"	"4"	"other biological processes"	"cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	""	"4637"	"ENSG00000092841"	"MYL6"	"hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5"	"Ciliary landscape"	"RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs"	"8"	"0"	"198.9"	"160.9"	"215.2"	"274.3"	"336.4"	"287.5"	"840.4"	"854.5"	"709.2"	"919.6"	"1153.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14818"	"Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1"	"22"	"6"	"11"	"6"	"248"	"27.9"	"8.46"	"1972.73"	"14.46"	"6"	"5"	"protein metabolism;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00227, Pf10584"	"5688"	"ENSG00000101182"	"PSMA7"	"B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"241.1"	"155.5"	"225.8"	"326.6"	"380.5"	"348.9"	"968.5"	"968.4"	"591.1"	"750.7"	"1105.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5JRX3"	"Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3"	"5"	"4"	"8"	"4"	"1037"	"117.3"	"6.92"	"1339.30"	"14.46"	"4"	"4"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport"	"mitochondrion"	"enzyme regulator activity;other molecular function"	"Pf00675, Pf05193, Pf08367"	"10531"	"ENSG00000107959"	"PITRM1"	"B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8"	""	"Mitochondrial protein import"	"1"	"0"	"57.4"	"41.7"	"69.1"	"80.4"	"98.6"	"92.8"	"193.3"	"189.3"	"144.8"	"325.2"	"1098.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NR31"	"GTP-binding protein SAR1a OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1"	"27"	"4"	"7"	"4"	"198"	"22.4"	"6.68"	"1057.78"	"14.44"	"3"	"3"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;ER/Golgi"	"other molecular function"	"Pf00025"	"56681"	"ENSG00000079332"	"SAR1A"	"B4DQ19; hsa:56681; Q9NR31"	"Sterol regulatory element-binding proteins (SREBP) signaling"	""	"1"	"0"	"45.7"	"25.5"	"53.3"	"93.3"	"95.5"	"90.2"	"138.5"	"146.8"	"100.4"	"129.2"	"188.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43795"	"Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3"	"4"	"5"	"9"	"4"	"1136"	"131.9"	"9.38"	"1365.66"	"14.41"	"4"	"5"	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00063, Pf00612, Pf06017"	"4430"	"ENSG00000128641"	"MYO1B"	"hsa:4430; O43794; O43795; Q7Z6L5"	""	""	"0"	"0"	"73.1"	"46.5"	"66.5"	"95.6"	"119.6"	"113.7"	"242.7"	"261.0"	"193.8"	"262.2"	"295.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99615"	"DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2"	"11"	"6"	"12"	"6"	"494"	"56.4"	"6.96"	"1751.68"	"14.39"	"6"	"6"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00226, Pf13181, Pf13414, Pf13432"	"7266"	"ENSG00000168259"	"DNAJC7"	"hsa:7266; Q7Z784; Q99615"	"Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway"	"Regulation of HSF1-mediated heat shock response"	"4"	"0"	"191.3"	"143.1"	"244.8"	"373.5"	"461.0"	"422.1"	"1478.8"	"1446.6"	"900.6"	"1014.0"	"1020.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L7X3"	"Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1"	"3"	"3"	"8"	"2"	"1001"	"116.0"	"7.65"	"1793.03"	"14.36"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;other cell component"	"enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function"	"Pf00069"	"57551"	"ENSG00000160551"	"TAOK1"	"A2RUT8; B7ZLV6; hsa:57551; Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6"	"Microtubule cytoskeleton regulation; MAPK signaling pathway"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"8"	"1"	"60.8"	"44.4"	"59.7"	"94.4"	"106.4"	"83.3"	"349.0"	"454.5"	"289.0"	"409.2"	"619.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96C36"	"Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1"	"16"	"4"	"8"	"3"	"320"	"33.6"	"7.77"	"1520.82"	"14.34"	"4"	"4"	"other metabolic processes;stress response"	"mitochondrion"	"other molecular function"	"Pf03807, Pf14748"	"29920"	"ENSG00000143811"	"PYCR2"	"A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4"	"Metabolic reprogramming in colon cancer"	"Glutamate and glutamine metabolism"	"2"	"1"	"122.3"	"95.7"	"134.6"	"165.0"	"218.6"	"188.9"	"437.8"	"459.7"	"312.3"	"426.1"	"568.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9GZS3"	"WD repeat-containing protein 61 OS=Homo sapiens OX=9606 GN=WDR61 PE=1 SV=1"	"15"	"3"	"7"	"3"	"305"	"33.6"	"5.47"	"1007.24"	"14.30"	"3"	"3"	"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf00400"	"80349"	"ENSG00000140395"	"SKIC8"	"D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3"	""	"E3 ubiquitin ligases ubiquitinate target proteins; mRNA decay by 3' to 5' exoribonuclease; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events"	"5"	"0"	"46.4"	"31.2"	"37.3"	"59.5"	"72.8"	"72.7"	"146.1"	"148.7"	"93.2"	"118.2"	"136.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4Z0"	"U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1"	"28"	"5"	"11"	"5"	"139"	"15.3"	"9.99"	"2034.54"	"14.30"	"5"	"4"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01423"	"25804"	"ENSG00000130520"	"LSM4"	"hsa:25804; Q9Y4Z0"	"Ciliary landscape"	"mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease"	"3"	"0"	"300.8"	"189.0"	"277.6"	"337.3"	"429.1"	"393.0"	"1095.3"	"1062.1"	"681.7"	"878.1"	"1227.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99733"	"Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1"	"15"	"5"	"9"	"4"	"375"	"42.8"	"4.69"	"1372.60"	"14.27"	"4"	"5"	"cell organization and biogenesis"	"nucleus;other cell component"	"other molecular function"	"Pf00956"	"4676"	"ENSG00000205531; ENSG00000273562"	"NAP1L4"	"B2R6J4; F5HFY4; hsa:4676; Q99733"	""	""	"0"	"0"	"55.5"	"41.0"	"57.2"	"76.9"	"88.5"	"87.6"	"255.6"	"261.3"	"161.9"	"213.1"	"255.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WVV9"	"Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1"	"6"	"3"	"9"	"2"	"542"	"60.0"	"7.72"	"1265.95"	"14.25"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf11835, Pf13893"	"92906"	"ENSG00000143889"	"HNRNPLL"	"hsa:92906; Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q8WVV9; Q96HR5"	""	""	"0"	"0"	"42.8"	"33.3"	"51.0"	"63.3"	"70.2"	"69.9"	"184.0"	"140.4"	"76.1"	"99.1"	"115.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7RTV0"	"PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1"	"45"	"5"	"8"	"5"	"110"	"12.4"	"8.41"	"828.64"	"14.23"	"3"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf03660"	"84844"	"ENSG00000100410"	"PHF5A"	"hsa:84844; Q7RTV0; Q9UH06"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"413.6"	"265.7"	"408.6"	"482.3"	"589.6"	"506.5"	"1686.5"	"1522.2"	"965.3"	"1363.4"	"1620.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30050"	"60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1"	"33"	"5"	"11"	"5"	"165"	"17.8"	"9.42"	"2099.52"	"14.14"	"5"	"4"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00298, Pf03946"	"6136"	"ENSG00000197958"	"RPL12"	"hsa:6136; P30050; Q5VVV2; Q6PB27"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"515.8"	"268.8"	"440.1"	"518.1"	"666.6"	"542.2"	"2778.9"	"2521.5"	"1417.3"	"1815.8"	"2327.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35221"	"Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1"	"7"	"6"	"10"	"6"	"906"	"100.0"	"6.29"	"1560.93"	"14.11"	"5"	"5"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf01044"	"1495"	"ENSG00000044115"	"CTNNA1"	"hsa:1495; P35221; Q12795; Q8N1C0"	"Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma"	"RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions"	"15"	"0"	"180.6"	"146.3"	"178.9"	"253.7"	"346.4"	"287.9"	"645.7"	"582.2"	"366.7"	"525.8"	"672.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20962"	"Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2"	"23"	"2"	"8"	"2"	"102"	"11.5"	"4.16"	"1703.24"	"14.09"	"2"	"2"	"DNA metabolism;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf03247"	"5763"	"ENSG00000159335"	"PTMS"	"hsa:5763; P20962"	"IL-18 signaling pathway"	""	"1"	"0"	"124.3"	"71.3"	"113.0"	"130.3"	"166.8"	"152.2"	"294.6"	"313.1"	"188.5"	"223.5"	"319.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P016"	"Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1"	"26"	"5"	"10"	"5"	"225"	"25.7"	"9.25"	"1841.15"	"14.07"	"5"	"5"	""	""	""	"Pf01878"	"29087"	"ENSG00000151500"	"THYN1"	"hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016"	""	""	"0"	"0"	"117.6"	"68.7"	"125.7"	"159.9"	"193.2"	"176.7"	"791.3"	"761.2"	"478.5"	"630.5"	"860.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q00535"	"Cyclin-dependent-like kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3"	"14"	"4"	"10"	"4"	"292"	"33.3"	"7.66"	"1720.61"	"14.05"	"4"	"4"	"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function"	"Pf00069"	"1020"	"ENSG00000164885"	"CDK5"	"A1XKG3; hsa:1020; Q00535"	"miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response"	"DARPP-32 events; NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Activated NTRK2 signals through CDK5"	"16"	"0"	"109.2"	"86.7"	"121.6"	"163.4"	"206.5"	"178.2"	"811.9"	"1965.4"	"1734.6"	"2587.0"	"3124.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12236"	"ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4"	"11"	"3"	"8"	"1"	"298"	"32.8"	"9.74"	"1543.30"	"14.03"	"3"	"3"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity"	"Pf00153"	"293"	"ENSG00000169100"	"SLC25A6"	"hsa:293; P12236; Q96C49"	"Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Mitochondrial protein import; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Influenza Virus Induced Apoptosis; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization"	"7"	"0"	"57.2"	"32.2"	"48.8"	"66.1"	"73.7"	"55.9"	"152.4"	"135.9"	"71.3"	"121.2"	"160.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P15531"	"Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1"	"32"	"4"	"8"	"1"	"152"	"17.1"	"6.19"	"1520.28"	"14.01"	"4"	"4"	"DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"translation activity;kinase activity;other molecular function"	"Pf00334"	"4830"	"ENSG00000239672"	"NME1"	"hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6"	"Pyrimidine metabolism"	"Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME"	"4"	"3"	"212.3"	"185.5"	"238.1"	"296.6"	"381.8"	"372.6"	"743.9"	"637.5"	"389.1"	"621.9"	"1311.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35240"	"Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1"	"9"	"6"	"11"	"5"	"595"	"69.6"	"6.47"	"1821.11"	"14.01"	"5"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity"	"Pf00373, Pf00769, Pf09379, Pf09380, Pf20492"	"4771"	"ENSG00000186575"	"NF2"	"hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4"	"Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma"	"Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs"	"10"	"0"	"48.9"	"32.1"	"49.6"	"67.2"	"91.2"	"67.5"	"314.1"	"283.0"	"206.4"	"314.9"	"469.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16698"	"2,4-dienoyl-CoA reductase, mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1"	"16"	"4"	"7"	"4"	"335"	"36.0"	"9.28"	"1033.59"	"13.99"	"3"	"4"	"other metabolic processes;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf13561"	"1666"	"ENSG00000104325"	"DECR1"	"B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085"	"Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling"	"mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"	"4"	"0"	"79.8"	"76.6"	"90.4"	"119.0"	"149.5"	"122.9"	"743.9"	"743.5"	"494.7"	"613.9"	"715.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16891"	"MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1"	"7"	"7"	"14"	"7"	"758"	"83.6"	"6.48"	"2559.32"	"13.99"	"7"	"5"	"cell organization and biogenesis;other biological processes"	"other membranes;mitochondrion"	""	"Pf09731"	"10989"	"ENSG00000132305"	"IMMT"	"B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2"	""	"Cristae formation"	"1"	"0"	"980.1"	"519.3"	"725.6"	"929.4"	"1239.4"	"1047.4"	"2130.0"	"1564.5"	"724.0"	"1511.7"	"1897.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NWB6"	"Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1"	"14"	"5"	"10"	"5"	"273"	"33.2"	"10.35"	"1534.57"	"13.97"	"5"	"5"	""	"cytosol;mitochondrion;nucleus"	""	"Pf15346"	"55082"	"ENSG00000134884"	"ARGLU1"	"B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6"	""	""	"0"	"0"	"390.0"	"252.1"	"360.6"	"446.2"	"584.3"	"521.1"	"1692.9"	"1505.8"	"885.4"	"1297.8"	"1778.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43395"	"U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2"	"9"	"5"	"8"	"5"	"683"	"77.5"	"9.50"	"815.53"	"13.93"	"3"	"5"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus"	"other molecular function"	"Pf01480, Pf06544, Pf08572"	"9129"	"ENSG00000117360"	"PRPF3"	"B4DSY9; hsa:9129; O43395; O43446; Q5VT54"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"132.6"	"97.4"	"122.5"	"156.4"	"215.1"	"166.8"	"501.8"	"465.4"	"293.8"	"370.0"	"403.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26358"	"DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2"	"4"	"5"	"10"	"5"	"1616"	"183.1"	"7.75"	"1839.79"	"13.92"	"5"	"5"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00145, Pf01426, Pf02008, Pf06464, Pf12047"	"1786"	"ENSG00000130816"	"DNMT1"	"A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6"	"Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency"	"SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation"	"10"	"0"	"63.0"	"44.3"	"70.3"	"79.7"	"110.8"	"89.5"	"437.5"	"403.4"	"287.7"	"340.5"	"397.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22392"	"Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1"	"35"	"4"	"8"	"1"	"152"	"17.3"	"8.41"	"1367.56"	"13.90"	"4"	"4"	"cell adhesion;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"non-structural extracellular;cytosol;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf00334"	"4831; 654364"	"ENSG00000243678"	"NME2"	"A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6"	"Pyrimidine metabolism"	"Neutrophil degranulation; Azathioprine ADME; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME"	"5"	"0"	"7.3"	"6.9"	"4.7"	"7.3"	"8.3"	"7.5"	"13.4"	"12.8"	"15.2"	"12.0"	"23.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NI27"	"THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2"	"2"	"4"	"10"	"4"	"1593"	"182.7"	"8.44"	"1540.75"	"13.82"	"4"	"4"	"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf11262, Pf11732, Pf16134"	"57187"	"ENSG00000125676"	"THOC2"	"A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"3"	"0"	"275.7"	"177.3"	"258.2"	"340.5"	"456.2"	"380.8"	"1035.5"	"990.3"	"628.4"	"952.8"	"1253.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13263"	"Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5"	"5"	"5"	"9"	"5"	"835"	"88.5"	"5.77"	"1259.24"	"13.80"	"4"	"5"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf00628, Pf00643, Pf14634"	"10155"	"ENSG00000130726"	"TRIM28"	"hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1"	"Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease"	"HCMV Early Events; SUMOylation of transcription cofactors; Generic Transcription Pathway"	"6"	"0"	"330.0"	"225.5"	"317.1"	"441.9"	"572.6"	"472.3"	"976.1"	"857.2"	"497.3"	"775.7"	"935.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L576"	"Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1"	"4"	"5"	"10"	"2"	"1253"	"145.1"	"6.90"	"1554.15"	"13.78"	"5"	"5"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;cytosol;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf05994, Pf07159"	"23191"	"ENSG00000273749; ENSG00000288461"	"CYFIP1"	"A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7"	"Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway"	"Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle"	"15"	"0"	"8.5"	"7.2"	"11.9"	"14.2"	"20.1"	"17.7"	"82.4"	"76.1"	"72.6"	"86.2"	"114.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09497"	"Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1"	"14"	"4"	"8"	"4"	"229"	"25.2"	"4.64"	"1458.89"	"13.78"	"4"	"4"	"transport"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf01086"	"1212"	"ENSG00000175416"	"CLTB"	"hsa:1212; P09497; Q53Y37; Q6FHW1"	"Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation"	"Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions"	"11"	"0"	"211.7"	"129.3"	"237.1"	"294.7"	"352.7"	"303.6"	"593.6"	"552.1"	"332.3"	"470.1"	"525.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62910"	"60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2"	"22"	"3"	"9"	"3"	"135"	"15.9"	"11.33"	"1338.84"	"13.73"	"3"	"3"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf01655"	"6161"	"ENSG00000144713"	"RPL32"	"B2R4Q3; hsa:6161; P02433; P62910"	"Cytoplasmic ribosomal proteins"	"SRP-dependent cotranslational protein targeting to membrane; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"159.1"	"127.7"	"158.6"	"190.0"	"247.5"	"214.9"	"783.7"	"710.6"	"594.3"	"724.8"	"704.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10606"	"Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2"	"34"	"4"	"8"	"4"	"129"	"13.7"	"8.81"	"1483.66"	"13.65"	"4"	"4"	"other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf01215"	"1329"	"ENSG00000135940"	"COX5B"	"hsa:1329; P10606; Q53YB7; Q96J18; Q99610"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation"	"Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1"	"7"	"0"	"437.5"	"286.8"	"369.2"	"511.7"	"661.8"	"593.2"	"1067.2"	"964.2"	"704.0"	"907.8"	"1090.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13428"	"Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3"	"4"	"6"	"11"	"6"	"1488"	"152.0"	"9.04"	"2109.76"	"13.62"	"6"	"5"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf03546"	"6949"	"ENSG00000070814"	"TCOF1"	"A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860"	""	""	"0"	"0"	"265.1"	"164.7"	"239.1"	"355.9"	"446.8"	"437.2"	"1510.9"	"1245.0"	"698.6"	"827.1"	"1114.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WVC0"	"RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1"	"11"	"7"	"11"	"7"	"666"	"75.4"	"4.51"	"1724.95"	"13.58"	"6"	"5"	"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytoskeleton;nucleus"	"other molecular function"	"Pf04004"	"123169"	"ENSG00000166477"	"LEO1"	"hsa:123169; Q8WVC0; Q96N99"	"Endoderm differentiation"	"Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex"	"6"	"0"	"202.7"	"123.6"	"194.0"	"273.5"	"331.7"	"304.8"	"1096.3"	"1122.0"	"663.1"	"909.0"	"1164.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02809"	"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2"	"9"	"4"	"8"	"4"	"727"	"83.5"	"6.95"	"1635.88"	"13.50"	"4"	"4"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"other membranes;ER/Golgi;other cell component"	"other molecular function"	"Pf03171"	"5351"	"ENSG00000083444"	"PLOD1"	"B4DR87; hsa:5351; Q02809; Q96AV9; Q9H132"	"Type I collagen synthesis in the context of osteogenesis imperfecta"	"Collagen biosynthesis and modifying enzymes"	"2"	"0"	"68.4"	"49.4"	"86.1"	"111.6"	"128.4"	"108.0"	"309.0"	"298.3"	"207.1"	"250.3"	"297.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95218"	"Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2"	"12"	"4"	"9"	"4"	"330"	"37.4"	"10.01"	"1832.11"	"13.50"	"4"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00641"	"9406"	"ENSG00000132485"	"ZRANB2"	"D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63"	""	""	"0"	"0"	"376.5"	"229.8"	"380.6"	"505.8"	"567.5"	"549.1"	"2044.7"	"1842.1"	"972.7"	"1226.6"	"1597.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55735"	"Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3"	"12"	"3"	"8"	"3"	"322"	"35.5"	"5.48"	"1394.68"	"13.45"	"3"	"3"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00400"	"6396"	"ENSG00000157020"	"SEC13"	"A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7"	"Sterol regulatory element-binding proteins (SREBP) signaling"	"Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RHO GTPases Activate Formins; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Separation of Sister Chromatids; HCMV Late Events; Resolution of Sister Chromatid Cohesion; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; COPII-mediated vesicle transport; Postmitotic nuclear pore complex (NPC) reformation"	"40"	"0"	"131.0"	"91.5"	"152.5"	"253.1"	"268.2"	"237.5"	"497.7"	"500.3"	"249.4"	"366.5"	"452.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62847"	"40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1"	"29"	"3"	"8"	"3"	"133"	"15.4"	"10.78"	"1471.60"	"13.41"	"3"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01282"	"6229"	"ENSG00000138326"	"RPS24"	"E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"173.4"	"112.8"	"165.0"	"204.0"	"228.6"	"218.2"	"646.0"	"570.9"	"377.3"	"521.7"	"708.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q04760"	"Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4"	"29"	"4"	"7"	"4"	"184"	"20.8"	"5.31"	"1370.37"	"13.39"	"3"	"4"	"other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00903"	"2739"	"ENSG00000124767"	"GLO1"	"B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41"	""	"Pyruvate metabolism"	"1"	"0"	"189.9"	"173.2"	"210.1"	"219.5"	"281.3"	"286.5"	"439.7"	"426.7"	"305.5"	"559.8"	"1092.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20073"	"Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3"	"10"	"4"	"8"	"4"	"488"	"52.7"	"5.68"	"1362.53"	"13.37"	"4"	"4"	"other metabolic processes;other biological processes"	"other membranes;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00191"	"310"	"ENSG00000138279"	"ANXA7"	"hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7"	""	""	"0"	"0"	"88.5"	"58.1"	"74.9"	"110.2"	"145.7"	"134.1"	"217.9"	"216.7"	"154.4"	"195.1"	"305.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IXB1"	"DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2"	"5"	"3"	"7"	"3"	"793"	"91.0"	"7.18"	"1177.02"	"13.35"	"2"	"3"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"ER/Golgi"	"other molecular function"	"Pf00085, Pf00226"	"54431"	"ENSG00000077232"	"DNAJC10"	"hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6"	""	""	"0"	"0"	"81.8"	"60.4"	"92.9"	"129.9"	"163.6"	"152.0"	"479.4"	"494.7"	"357.8"	"468.1"	"583.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P27635"	"60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4"	"16"	"3"	"8"	"3"	"214"	"24.6"	"10.08"	"1470.52"	"13.25"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf00252"	"100137264; 100146244; 100172946; 100415355; 100468790; 100724614; 100982236; 101083663; 101136536; 101344695; 101444008; 101539056; 101690567; 101867181; 101975002; 102028809; 102257301; 102442647; 102878669; 102890423; 102923570; 102957760; 103127392; 103211225; 103250904; 103731218; 104667036; 104872587; 105294701; 105302495; 105467951; 105521640; 105579731; 105727260; 105824536; 105867804; 106000161; 107160308; 108513162; 108518769; 109696857; 110954; 465944; 700795; 81764"	"ENSAMEG00000000227; ENSANAG00000036053; ENSCAFG00020009114; ENSCAFG00030015144; ENSCAFG00040021422; ENSCAFG00845028627; ENSCANG00000032226; ENSCATG00000030970; ENSCCAG00000024992; ENSCGRG00001008387; ENSCJAG00000011822; ENSCLAG00000003108; ENSCPOG00000002355; ENSECAG00000017154; ENSFCAG00000011395; ENSGGOG00000000131; ENSLCNG00005021252; ENSMFAG00000040824; ENSMLUG00000014337; ENSMMMG00000014279; ENSMMUG00000005494; ENSMNEG00000038094; ENSMPUG00000009320; ENSMUSG00000008682; ENSMUSG00000058443; ENSNGAG00000023746; ENSNLEG00000028143; ENSNVIG00000023818; ENSPANG00000008309; ENSPCOG00000027122; ENSPPAG00000034160; ENSPPYG00000020874; ENSPSMG00000015404; ENSPTIG00000005599; ENSPTRG00000043378; ENSRBIG00000042996; ENSRNOG00000056765; ENSRROG00000019247; ENSSSUG00005010590; ENSSTOG00000011857; ENSTGEG00000012563; ENSUAMG00000020454; ENSUMAG00000019583; ENSUPAG00010000252"	"LOC100768740; LOC101344695; LOC105294701; LOC112632580; Rpl10; RPL10"	"A0A091D943; A0A1S3APJ4; A0A1S3GPT7; A0A1U7SU42; A0A250YCK6; A0A286XQR8; A0A2I3FV08; A0A2J8IN69; A0A2J8RLU6; A0A2K5EV78; A0A2K5ILK8; A0A2K5LLF2; A0A2K5QER4; A0A2K5U275; A0A2K6D043; A0A2K6GRP4; A0A2K6MTH0; A0A2K6NK39; A0A2R9B361; A0A2Y9G5G6; A0A384DKX1; A0A3Q0CF07; A0A3Q7NJC4; A0A452S2Z9; A0A485PEW4; A0A667IJV2; A0A673U4F8; A0A6D2WIN2; A0A6D2XTB8; A0A6I9ME29; A0A6J0A9X4; A0A6J2E7G1; A0A6J3GU06; A0A6P3QFP2; A0A6P5P1X6; A0A6P6DLY1; A0A7J7YFN8; A0A7J8J7V5; A0A822A0T4; A0A8B7B976; A0A8B7FW91; A0A8C0K7J7; A0A8C0TBM4; A0A8C2LMI8; A0A8C2UVN1; A0A8C5ZPE8; A0A8C6S1T7; A0A8C7BXJ2; A0A8C8ZPD3; A0A8C9J452; A0A8D2F5T2; A0A8D2GF85; A0A8I3PXJ3; A0A8J8XDM4; A0A8M1M1S6; A0A9B0U593; A2AM97; A6KRS1; A9CB60; aju:106987320; aml:100468790; B0KWW6; B1MTV1; B3RFD9; C3PT02; cang:105521640; caty:105579731; ccan:109696857; cpoc:100724614; csyr:103250904; D3YC00; dnm:101444008; dord:106000161; ecb:100146244; F7AYR2; F7GKJ8; fca:101083663; G1PPT9; G2HFW2; G3S9Q9; G7Q3B3; ggo:101136536; H2PX84; I2CYS4; I3MI39; L5KDV0; L8Y8T7; M3WF14; M3YD39; mcal:110286529; mcc:700795; mcf:101867181; mlf:102442647; mmu:110954; mmur:105867804; mni:105467951; mpuf:101690567; myb:102257301; nsu:110578606; P45634; pale:102878669; pale:102890423; panu:100137264; pcoq:105824536; pps:100982236; ptg:102957760; ptr:465944; pvp:105294701; pvp:105302495; Q569M8; Q5M9K8; Q6PDV7; Q6ZWV3; rbb:108513162; rbb:108518769; rno:81764; rro:104667036; S7NR49; sara:101539056; tmu:101344695; umr:103679662; zca:113931110"	"Cytoplasmic ribosomal proteins"	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"	"15"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5RKV6"	"Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1"	"17"	"3"	"6"	"3"	"272"	"28.2"	"6.28"	"628.87"	"13.24"	"2"	"3"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	""	"Pf01138"	"118460"	"ENSG00000223496"	"EXOSC6"	"hsa:118460; Q5RKV6"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"6"	"0"	"130.4"	"80.2"	"124.0"	"155.5"	"199.0"	"181.6"	"415.9"	"436.3"	"284.8"	"349.4"	"455.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60900"	"Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1"	"22"	"4"	"7"	"4"	"246"	"27.4"	"6.76"	"1221.61"	"13.24"	"3"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00227, Pf10584"	"5687"	"ENSG00000100902"	"PSMA6"	"B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"117.7"	"109.8"	"123.7"	"158.2"	"190.1"	"172.4"	"481.7"	"517.4"	"364.6"	"425.1"	"498.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15226"	"NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2"	"9"	"5"	"9"	"5"	"690"	"77.6"	"8.79"	"1778.03"	"13.22"	"5"	"4"	"other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01424, Pf01585"	"55922"	"ENSG00000186416"	"NKRF"	"G3V1N1; hsa:55922; O15226; Q4VC41; Q9UJ91"	"Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway"	""	"2"	"0"	"111.8"	"77.9"	"118.4"	"173.6"	"193.7"	"170.9"	"509.2"	"429.5"	"279.6"	"393.6"	"492.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13427"	"Peptidyl-prolyl cis-trans isomerase G OS=Homo sapiens OX=9606 GN=PPIG PE=1 SV=2"	"7"	"5"	"10"	"5"	"754"	"88.6"	"10.29"	"1483.43"	"13.21"	"5"	"5"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00160"	"9360"	"ENSG00000138398"	"PPIG"	"D3DPC5; D3DPC6; hsa:9360; O00706; Q13427; Q53R40; Q53SN4; Q96DG9"	""	"mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses"	"2"	"0"	"184.8"	"108.5"	"159.3"	"184.7"	"263.1"	"235.5"	"741.5"	"614.5"	"352.6"	"618.4"	"809.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96SI9"	"Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1"	"6"	"4"	"9"	"2"	"672"	"73.6"	"8.72"	"1858.77"	"13.19"	"4"	"3"	"other biological processes"	"cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity"	"Pf00035, Pf07528"	"55342"	"ENSG00000165209"	"STRBP"	"hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4"	""	""	"0"	"0"	"67.0"	"37.0"	"56.8"	"84.6"	"107.3"	"94.6"	"219.7"	"192.6"	"105.8"	"175.1"	"300.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92769"	"Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2"	"9"	"3"	"8"	"1"	"488"	"55.3"	"5.91"	"1759.26"	"13.18"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00850"	"3066"	"ENSG00000196591"	"HDAC2"	"B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769"	"Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway"	"HDACs deacetylate histones; NoRC negatively regulates rRNA expression; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of chromatin organization proteins; Potential therapeutics for SARS; Factors involved in megakaryocyte development and platelet production; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; Regulation of TP53 Activity through Acetylation; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels"	"30"	"0"	"16.9"	"9.2"	"14.3"	"21.3"	"21.5"	"22.8"	"47.3"	"37.5"	"26.8"	"41.0"	"49.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07195"	"L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2"	"12"	"4"	"8"	"4"	"334"	"36.6"	"6.05"	"1504.65"	"13.14"	"4"	"4"	"other metabolic processes"	"other membranes;cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00056, Pf02866"	"3945"	"ENSG00000111716"	"LDHB"	"hsa:3945; P07195"	"Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Pyruvate metabolism"	"5"	"0"	"364.7"	"235.5"	"363.9"	"440.8"	"545.2"	"659.8"	"849.1"	"732.2"	"450.4"	"718.4"	"1520.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43175"	"D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4"	"6"	"3"	"10"	"3"	"533"	"56.6"	"6.71"	"1657.77"	"13.05"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes"	"cytosol"	"other molecular function"	"Pf00389, Pf02826, Pf19304"	"26227"	"ENSG00000092621"	"PHGDH"	"B2RD08; hsa:26227; O43175; Q5SZU3; Q9BQ01"	"Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells"	"Serine biosynthesis"	"5"	"0"	"159.9"	"109.6"	"152.1"	"226.4"	"274.6"	"204.7"	"446.8"	"409.8"	"269.7"	"350.7"	"369.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NDT2"	"Putative RNA-binding protein 15B OS=Homo sapiens OX=9606 GN=RBM15B PE=1 SV=3"	"5"	"3"	"7"	"2"	"890"	"97.1"	"9.85"	"1023.65"	"13.01"	"2"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf07744"	"29890"	"ENSG00000259956"	"RBM15B"	"A4QPG7; hsa:29890; Q6QE19; Q8NDT2; Q9BV96"	""	""	"0"	"0"	"14.5"	"7.8"	"15.5"	"18.0"	"30.0"	"30.6"	"101.1"	"157.9"	"182.3"	"310.6"	"494.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12931"	"Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3"	"8"	"6"	"12"	"6"	"704"	"80.1"	"8.21"	"2122.59"	"13.00"	"6"	"5"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00183, Pf02518"	"10131"	"ENSG00000126602"	"TRAP1"	"B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5"	"TNF-alpha signaling pathway; Clock-controlled autophagy in bone metabolism"	"Respiratory electron transport"	"3"	"0"	"439.2"	"303.3"	"483.2"	"928.4"	"1055.2"	"839.8"	"1639.9"	"1570.3"	"895.1"	"1135.7"	"1376.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62888"	"60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2"	"48"	"6"	"10"	"5"	"115"	"12.8"	"9.63"	"2233.44"	"13.00"	"6"	"4"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01248"	"6156"	"ENSG00000156482"	"RPL30"	"B2R591; hsa:6156; P04645; P62888; Q502Z6"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"98.7"	"67.4"	"99.6"	"105.6"	"131.7"	"110.3"	"595.5"	"491.3"	"341.5"	"416.5"	"460.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15370"	"Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1"	"31"	"5"	"9"	"5"	"118"	"13.1"	"4.88"	"1954.44"	"12.98"	"5"	"4"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00240"	"6923"	"ENSG00000103363"	"ELOB"	"B7WPD3; hsa:6923; Q15370"	"Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation"	"Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes"	"21"	"0"	"519.3"	"266.1"	"489.4"	"688.9"	"812.5"	"737.9"	"1290.6"	"1318.0"	"731.5"	"966.9"	"1548.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62834"	"Ras-related protein Rap-1A OS=Homo sapiens OX=9606 GN=RAP1A PE=1 SV=1"	"27"	"5"	"9"	"5"	"184"	"21.0"	"6.67"	"1985.43"	"12.96"	"5"	"4"	"cell-cell signaling;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00071"	"5906"	"ENSG00000116473"	"RAP1A"	"hsa:5906; P10113; P62834"	"Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Ras signaling; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; DNA repair pathways, full network; GDNF signaling; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling"	"Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1"	"34"	"0"	"179.2"	"120.3"	"155.4"	"180.5"	"225.5"	"216.4"	"636.2"	"638.2"	"507.7"	"591.4"	"616.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49792"	"E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2"	"3"	"7"	"11"	"6"	"3224"	"358.0"	"6.20"	"1953.20"	"12.96"	"6"	"5"	"protein metabolism;other metabolic processes;transport;other biological processes"	"other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00160, Pf00638, Pf00641, Pf12185"	"5903"	"ENSG00000153201"	"RANBP2"	"hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7"	""	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"	"35"	"1"	"295.1"	"185.3"	"295.2"	"397.8"	"496.2"	"425.8"	"823.5"	"998.0"	"614.7"	"772.8"	"1532.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BTC0"	"Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5"	"2"	"3"	"5"	"3"	"2240"	"243.7"	"7.88"	"949.73"	"12.92"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes;signal transduction"	"cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00628, Pf07500, Pf07744"	"11083"	"ENSG00000101191"	"DIDO1"	"A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6"	""	""	"0"	"0"	"8.9"	"5.1"	"7.4"	"11.6"	"14.9"	"13.1"	"35.1"	"39.9"	"16.0"	"23.2"	"33.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75494"	"Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1"	"16"	"5"	"10"	"3"	"262"	"31.3"	"11.27"	"2067.05"	"12.87"	"5"	"4"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"10772"	"ENSG00000188529"	"SRSF10"	"A6NFM6; A6NI42; A6NIU7; B4DJP9; hsa:10772; O60572; O75494; Q5JRH9; Q5JRI0; Q5JRI2; Q5JRI3; Q5JRI4; Q96G09; Q96P17"	"mRNA processing"	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"3"	"2"	"181.6"	"114.6"	"140.4"	"181.1"	"267.3"	"207.1"	"538.4"	"597.8"	"409.8"	"758.5"	"823.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11940"	"Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2"	"7"	"4"	"9"	"4"	"636"	"70.6"	"9.50"	"1385.85"	"12.86"	"3"	"4"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf00658"	"26986"	"ENSG00000070756"	"PABPC1"	"hsa:26986; P11940; Q15097; Q93004"	"Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"11"	"0"	"323.5"	"192.2"	"288.3"	"393.5"	"500.0"	"401.4"	"1076.7"	"972.2"	"556.9"	"846.0"	"1015.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60610"	"Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2"	"4"	"5"	"9"	"5"	"1272"	"141.3"	"5.41"	"1781.76"	"12.85"	"5"	"4"	"cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf02181, Pf06346, Pf06367, Pf06371"	"1729"	"ENSG00000131504"	"DIAPH1"	"A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76"	"Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway"	"RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility"	"14"	"0"	"215.7"	"198.8"	"288.9"	"431.0"	"454.5"	"382.0"	"528.9"	"519.1"	"397.7"	"542.6"	"561.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86UP2"	"Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1"	"4"	"5"	"8"	"5"	"1357"	"156.2"	"5.64"	"1342.11"	"12.82"	"4"	"4"	"transport;other biological processes"	"plasma membrane;other membranes;ER/Golgi"	"cytoskeletal activity"	"Pf05104"	"3895"	"ENSG00000126777"	"KTN1"	"B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57"	"Glucocorticoid receptor pathway; Nuclear receptors meta-pathway"	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; RHO GTPases activate KTN1"	"11"	"0"	"56.0"	"32.6"	"51.4"	"76.9"	"87.5"	"74.5"	"235.7"	"224.0"	"120.0"	"187.6"	"235.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13547"	"Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1"	"9"	"4"	"9"	"2"	"482"	"55.1"	"5.48"	"2116.02"	"12.78"	"4"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00850"	"3065"	"ENSG00000116478"	"HDAC1"	"hsa:3065; Q13547; Q92534"	"Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome causing genes; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways"	"Potential therapeutics for SARS; Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA"	"54"	"3"	"327.9"	"229.3"	"364.9"	"496.4"	"592.6"	"518.9"	"932.0"	"919.1"	"628.4"	"774.3"	"1038.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P29966"	"Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4"	"12"	"3"	"8"	"3"	"332"	"31.5"	"4.45"	"1297.25"	"12.70"	"3"	"3"	"cell organization and biogenesis;stress response;developmental processes;other biological processes"	"plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf02063"	"4082"	"ENSG00000277443"	"MARCKS"	"E1P560; hsa:4082; P29966; Q2LA83; Q5TDB7"	"Brain-derived neurotrophic factor (BDNF) signaling pathway"	"Acetylcholine regulates insulin secretion"	"2"	"0"	"152.5"	"97.6"	"131.8"	"166.2"	"205.0"	"208.3"	"355.6"	"322.8"	"225.6"	"328.5"	"499.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P15311"	"Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4"	"8"	"4"	"8"	"3"	"586"	"69.4"	"6.27"	"1277.04"	"12.68"	"4"	"4"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00373, Pf00769, Pf09379, Pf09380, Pf20492"	"7430"	"ENSG00000092820"	"EZR"	"E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4"	"Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling"	"Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Netrin-1 signaling"	"11"	"1"	"91.8"	"58.5"	"87.0"	"116.7"	"157.3"	"119.8"	"764.0"	"754.6"	"537.2"	"830.6"	"1318.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20042"	"Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2"	"14"	"4"	"8"	"4"	"333"	"38.4"	"5.80"	"1438.69"	"12.67"	"4"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes"	"cytosol;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01873"	"8894"	"ENSG00000125977"	"EIF2S2"	"hsa:8894; P20042; Q9BVU0; Q9UJE4"	"Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency"	"14"	"0"	"86.5"	"43.8"	"64.6"	"89.2"	"124.9"	"110.6"	"516.8"	"540.7"	"330.9"	"524.3"	"962.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H3K6"	"BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2 PE=1 SV=1"	"49"	"3"	"6"	"3"	"86"	"10.1"	"6.52"	"1337.87"	"12.60"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf01722"	"552900; 654483"	"ENSG00000169627; ENSG00000183336"	"BOLA2; BOLA2B"	"A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6"	""	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"	"1"	"0"	"54.0"	"30.5"	"56.6"	"82.9"	"98.0"	"90.4"	"200.9"	"193.8"	"135.4"	"174.9"	"286.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43707"	"Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2"	"5"	"4"	"8"	"1"	"911"	"104.8"	"5.44"	"1476.25"	"12.59"	"4"	"4"	"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00307, Pf00435, Pf08726"	"81"	"ENSG00000130402; ENSG00000282844"	"ACTN4"	"A4K467; D6PXK4; hsa:81; O43707; O76048"	"Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome"	"Platelet degranulation ; Nephrin family interactions"	"9"	"0"	"43.6"	"32.7"	"56.1"	"66.3"	"73.3"	"78.3"	"128.9"	"140.8"	"94.6"	"139.2"	"213.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P27797"	"Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1"	"20"	"7"	"9"	"7"	"417"	"48.1"	"4.44"	"1413.42"	"12.54"	"5"	"4"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf00262"	"811"	"ENSG00000179218"	"CALR"	"hsa:811; P27797; Q6IAT4; Q9UDG2"	"Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells"	"Scavenging by Class A Receptors; Scavenging by Class F Receptors; ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Assembly of Viral Components at the Budding Site; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle"	"13"	"0"	"375.6"	"234.4"	"366.5"	"475.2"	"595.0"	"574.1"	"1241.1"	"1306.3"	"652.6"	"900.1"	"1485.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10515"	"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3"	"7"	"4"	"7"	"4"	"647"	"69.0"	"7.84"	"1083.93"	"12.51"	"3"	"4"	"other metabolic processes"	"mitochondrion;other cell component"	"other molecular function"	"Pf00198, Pf00364, Pf02817"	"1737"	"ENSG00000150768"	"DLAT"	"hsa:1737; P10515; Q16783; Q53EP3"	"TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid"	"8"	"0"	"304.1"	"228.9"	"324.1"	"431.2"	"472.3"	"421.7"	"448.9"	"432.7"	"313.9"	"405.2"	"855.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WXA9"	"Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1"	"7"	"3"	"5"	"3"	"508"	"59.3"	"10.39"	"601.91"	"12.48"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf00076"	"140890"	"ENSG00000153914"	"SREK1"	"A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9"	"mRNA processing"	""	"1"	"0"	"51.1"	"36.1"	"43.1"	"67.4"	"78.7"	"72.4"	"191.6"	"191.5"	"97.5"	"150.1"	"239.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L2H7"	"Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1"	"13"	"3"	"6"	"3"	"374"	"42.5"	"5.63"	"1286.22"	"12.46"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01399, Pf18005"	"10480"	"ENSG00000149100"	"EIF3M"	"A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1"	""	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition"	"6"	"0"	"58.5"	"27.9"	"54.9"	"63.3"	"81.4"	"68.4"	"136.3"	"128.9"	"72.2"	"115.5"	"141.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46060"	"Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1"	"6"	"4"	"8"	"4"	"587"	"63.5"	"4.68"	"1355.57"	"12.46"	"4"	"4"	"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf07834, Pf13516"	"5905"	"ENSG00000100401"	"RANGAP1"	"hsa:5905; P46060; Q96JJ2"	"22q11.2 copy number variation syndrome; IL-18 signaling pathway"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins"	"12"	"0"	"50.7"	"31.8"	"45.1"	"82.1"	"97.7"	"81.7"	"192.7"	"204.3"	"134.3"	"137.4"	"174.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q32P28"	"Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2"	"7"	"4"	"10"	"4"	"736"	"83.3"	"5.14"	"1473.45"	"12.44"	"4"	"4"	"protein metabolism;other metabolic processes;developmental processes;other biological processes"	"ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf13640"	"64175"	"ENSG00000117385"	"P3H1"	"hsa:64175; Q32P28; Q7KZR4; Q96BR8; Q96SK8; Q96SL5; Q96SN3; Q9H6K3; Q9HC86; Q9HC87"	"Type I collagen synthesis in the context of osteogenesis imperfecta"	"Collagen biosynthesis and modifying enzymes"	"2"	"0"	"219.2"	"177.2"	"241.8"	"334.8"	"397.5"	"381.1"	"653.4"	"676.3"	"499.0"	"674.4"	"955.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y230"	"RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3"	"10"	"4"	"8"	"4"	"463"	"51.1"	"5.64"	"1296.74"	"12.42"	"4"	"4"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf06068, Pf17856"	"10856"	"ENSG00000183207"	"RUVBL2"	"B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361"	""	"Telomere Extension By Telomerase; HATs acetylate histones"	"2"	"0"	"26.1"	"17.8"	"20.6"	"32.8"	"44.2"	"44.7"	"72.9"	"78.6"	"44.1"	"62.3"	"67.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q52LJ0"	"Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2"	"10"	"4"	"8"	"4"	"433"	"45.5"	"8.69"	"1259.40"	"12.42"	"4"	"4"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf10239"	"283742"	"ENSG00000171262"	"FAM98B"	"A8MUW5; hsa:283742; Q52LJ0; Q8N935"	""	"tRNA processing in the nucleus"	"1"	"0"	"94.3"	"70.3"	"111.2"	"133.0"	"174.8"	"153.4"	"499.7"	"411.9"	"304.7"	"358.9"	"499.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBL3"	"Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1"	"10"	"4"	"6"	"4"	"628"	"68.7"	"5.69"	"781.42"	"12.40"	"2"	"4"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00622"	"9070"	"ENSG00000129691"	"ASH2L"	"A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3"	"Kleefstra syndrome"	"Deactivation of the beta-catenin transactivating complex; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"	"7"	"0"	"30.7"	"22.1"	"34.1"	"42.6"	"56.6"	"50.2"	"120.7"	"122.9"	"79.9"	"99.0"	"123.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13825"	"Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1"	"12"	"3"	"6"	"3"	"339"	"35.6"	"9.48"	"987.76"	"12.40"	"2"	"3"	"other metabolic processes"	"mitochondrion"	"nucleic acid binding activity;other molecular function"	"Pf00378"	"549"	"ENSG00000148090"	"AUH"	"B1ALV7; B1ALV8; hsa:549; Q13825; Q8WUE4"	"Amino acid metabolism"	"Branched-chain amino acid catabolism"	"2"	"0"	"39.9"	"57.8"	"41.4"	"53.1"	"67.7"	"54.2"	"389.8"	"428.6"	"403.0"	"558.5"	"820.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P37802"	"Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3"	"31"	"4"	"7"	"4"	"199"	"22.4"	"8.25"	"1205.90"	"12.38"	"3"	"4"	"cell organization and biogenesis;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton"	"cytoskeletal activity"	"Pf00307, Pf00402"	"8407"	"ENSG00000158710"	"TAGLN2"	"E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0"	""	"Platelet degranulation"	"1"	"0"	"53.1"	"37.5"	"61.7"	"71.0"	"98.6"	"85.5"	"160.3"	"125.5"	"85.0"	"145.1"	"271.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P17480"	"Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1"	"4"	"2"	"6"	"2"	"764"	"89.4"	"5.81"	"1317.33"	"12.30"	"2"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00505, Pf09011, Pf14887"	"7343"	"ENSG00000108312"	"UBTF"	"A8K6R8; hsa:7343; P17480"	"Ectoderm differentiation"	"NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening"	"6"	"0"	"23.2"	"14.3"	"21.0"	"31.4"	"30.5"	"27.2"	"162.4"	"157.9"	"142.2"	"231.8"	"287.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61254"	"60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1"	"23"	"5"	"11"	"5"	"145"	"17.2"	"10.55"	"1830.01"	"12.25"	"5"	"4"	"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00467, Pf16906"	"6154"	"ENSG00000161970"	"RPL26"	"B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"370.1"	"208.4"	"308.1"	"379.1"	"482.9"	"436.2"	"2025.2"	"1816.8"	"1065.3"	"1459.5"	"1684.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WWY3"	"U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2"	"12"	"5"	"11"	"5"	"499"	"55.4"	"5.78"	"2312.01"	"12.25"	"5"	"4"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01798, Pf09785"	"26121"	"ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953"	"PRPF31"	"E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"150.8"	"98.1"	"131.1"	"183.6"	"219.1"	"193.9"	"654.6"	"567.7"	"483.8"	"572.2"	"730.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5JWF2"	"Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2"	"4"	"4"	"7"	"3"	"1037"	"111.0"	"5.03"	"1053.85"	"12.24"	"3"	"4"	"cell adhesion;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00503"	"2778"	"ENSG00000087460"	"GNAS"	"A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42"	"Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling"	"G alpha (i) signalling events; G alpha (z) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state"	"28"	"0"	"42.3"	"29.1"	"52.8"	"67.4"	"72.7"	"78.4"	"113.7"	"114.9"	"76.2"	"102.4"	"139.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25789"	"Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1"	"18"	"5"	"10"	"5"	"261"	"29.5"	"7.72"	"1428.83"	"12.23"	"5"	"5"	"protein metabolism;other metabolic processes"	"cytosol;nucleus;other cell component"	""	"Pf00227, Pf10584"	"5685"	"ENSG00000041357"	"PSMA4"	"D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"63"	"0"	"358.7"	"203.7"	"316.8"	"412.8"	"546.1"	"462.5"	"1101.8"	"1103.6"	"632.2"	"801.6"	"1150.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55196"	"Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3"	"3"	"4"	"7"	"4"	"1824"	"206.7"	"6.47"	"1514.38"	"12.19"	"4"	"3"	"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00498, Pf00595, Pf00788, Pf01843"	"4301"	"ENSG00000130396"	"AFDN"	"hsa:4301; O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92"	"VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome"	""	"3"	"0"	"21.9"	"8.3"	"27.8"	"34.2"	"35.7"	"32.8"	"138.3"	"147.2"	"121.3"	"216.6"	"410.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14498"	"RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2"	"7"	"4"	"10"	"4"	"530"	"59.3"	"10.10"	"1517.30"	"12.16"	"4"	"4"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00076, Pf15519"	"9584"	"ENSG00000131051"	"RBM39"	"A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499"	"VEGFA-VEGFR2 signaling; mRNA processing"	"mRNA Splicing - Major Pathway"	"3"	"0"	"389.7"	"278.9"	"347.5"	"544.6"	"673.7"	"556.6"	"1433.8"	"1234.2"	"617.8"	"943.4"	"1127.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15019"	"Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1"	"11"	"4"	"8"	"4"	"361"	"41.5"	"6.60"	"1394.24"	"12.14"	"4"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00735"	"4735"	"ENSG00000168385"	"SEPTIN2"	"B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0"	"2q37 copy number variation syndrome"	"Anchoring of the basal body to the plasma membrane"	"2"	"0"	"109.0"	"76.8"	"109.8"	"177.0"	"204.7"	"187.6"	"948.2"	"934.3"	"583.2"	"782.1"	"1164.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H0C8"	"Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1"	"10"	"4"	"8"	"4"	"392"	"42.9"	"7.09"	"1374.51"	"12.10"	"4"	"4"	"protein metabolism;other metabolic processes"	"cytosol;nucleus"	"other molecular function"	"Pf00481"	"80895"	"ENSG00000132323"	"ILKAP"	"B3KM39; hsa:80895; Q9H0C8"	"2q37 copy number variation syndrome"	""	"1"	"0"	"139.1"	"93.5"	"140.3"	"177.3"	"213.3"	"196.5"	"554.8"	"616.2"	"423.7"	"521.1"	"839.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13112"	"Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1"	"7"	"3"	"6"	"3"	"559"	"61.5"	"7.50"	"677.39"	"12.03"	"1"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response"	"nucleus;other cell component"	"other molecular function"	"Pf00400, Pf15512"	"8208"	"ENSG00000159259"	"CHAF1B"	"hsa:8208; Q13112; Q99548"	""	""	"0"	"0"	"8.2"	"13.3"	"15.6"	"18.1"	"22.8"	"27.2"	"72.8"	"67.9"	"47.9"	"55.2"	"65.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50395"	"Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2"	"10"	"4"	"7"	"4"	"445"	"50.6"	"6.47"	"1079.36"	"12.02"	"3"	"4"	"transport;signal transduction;other biological processes"	"non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00996"	"2665"	"ENSG00000057608"	"GDI2"	"hsa:2665; O43928; P50395; Q5SX88; Q9UQM6"	""	"Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs"	"2"	"0"	"72.8"	"82.1"	"96.8"	"119.6"	"161.1"	"160.5"	"232.0"	"223.7"	"174.7"	"249.4"	"400.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NTI5"	"Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1"	"3"	"3"	"6"	"3"	"1447"	"164.6"	"8.47"	"1138.57"	"11.93"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf20168"	"23047"	"ENSG00000083642"	"PDS5B"	"hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451"	"Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin"	"6"	"0"	"36.7"	"26.1"	"39.9"	"45.0"	"58.3"	"48.7"	"186.7"	"180.9"	"117.8"	"133.9"	"156.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NUP9"	"Protein lin-7 homolog C OS=Homo sapiens OX=9606 GN=LIN7C PE=1 SV=1"	"22"	"5"	"11"	"2"	"197"	"21.8"	"8.43"	"1800.06"	"11.92"	"5"	"4"	"cell-cell signaling;transport;other biological processes"	"plasma membrane;other membranes;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00595, Pf02828"	"55327"	"ENSG00000148943"	"LIN7C"	"hsa:55327; Q9NUP9"	""	"Neurexins and neuroligins; Assembly and cell surface presentation of NMDA receptors; Dopamine Neurotransmitter Release Cycle"	"3"	"3"	"406.7"	"292.9"	"395.3"	"657.2"	"739.4"	"650.7"	"1599.6"	"1560.5"	"1103.2"	"1386.4"	"1831.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UN86"	"Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2"	"9"	"4"	"8"	"4"	"482"	"54.1"	"5.55"	"1414.09"	"11.91"	"4"	"4"	"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes"	"cytosol;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf02136"	"9908"	"ENSG00000138757"	"G3BP2"	"A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1"	""	"SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"1"	"0"	"232.5"	"123.7"	"234.8"	"345.3"	"385.8"	"366.2"	"657.5"	"667.5"	"360.3"	"474.7"	"731.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92979"	"Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4"	"20"	"3"	"5"	"3"	"244"	"26.7"	"9.17"	"1017.21"	"11.85"	"2"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03587"	"10436"	"ENSG00000126749"	"EMG1"	"hsa:10436; O00675; O00726; Q92979"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"26.7"	"20.2"	"29.9"	"34.0"	"49.3"	"40.6"	"134.2"	"141.9"	"110.0"	"173.4"	"198.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IYB3"	"Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2"	"3"	"2"	"6"	"2"	"904"	"102.3"	"11.84"	"1403.44"	"11.84"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"nucleic acid binding activity"	"Pf01480"	"10250"	"ENSG00000133226"	"SRRM1"	"hsa:10250; O60585; Q5VVN4; Q8IYB3"	"mRNA processing"	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle"	"7"	"0"	"103.0"	"65.4"	"90.3"	"118.0"	"154.7"	"127.6"	"430.1"	"396.6"	"240.7"	"355.0"	"379.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75369"	"Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2"	"2"	"5"	"10"	"4"	"2602"	"278.0"	"5.73"	"1370.62"	"11.84"	"5"	"5"	"cell organization and biogenesis;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf00630"	"2317"	"ENSG00000136068"	"FLNB"	"B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9"	"Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome"	"ISG15 antiviral mechanism"	"6"	"0"	"117.1"	"85.3"	"115.5"	"177.4"	"208.8"	"190.0"	"376.2"	"382.9"	"221.3"	"272.4"	"426.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63220"	"40S ribosomal protein S21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1"	"48"	"4"	"9"	"4"	"83"	"9.1"	"8.50"	"1755.51"	"11.80"	"4"	"4"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01249"	"6227"	"ENSG00000171858"	"RPS21"	"hsa:6227; P35265; P63220"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"521.1"	"337.9"	"511.6"	"569.9"	"617.9"	"547.8"	"2296.9"	"2029.2"	"1320.0"	"1462.9"	"1855.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N6N3"	"UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1"	"20"	"3"	"7"	"3"	"182"	"20.6"	"5.21"	"857.48"	"11.79"	"2"	"3"	""	"nucleus"	""	"Pf15559"	"148423"	"ENSG00000162642"	"C1orf52"	"B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6"	""	""	"0"	"0"	"59.5"	"32.9"	"56.9"	"70.3"	"73.8"	"70.3"	"158.2"	"164.6"	"94.9"	"117.1"	"170.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02218"	"2-oxoglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3"	"5"	"4"	"8"	"4"	"1023"	"115.9"	"6.86"	"1291.63"	"11.77"	"4"	"4"	"protein metabolism;other metabolic processes;developmental processes"	"other membranes;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00676, Pf02779, Pf16078, Pf16870"	"4967"	"ENSG00000105953"	"OGDH"	"B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0"	"TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)"	"Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Lysine catabolism"	"8"	"0"	"50.4"	"30.6"	"49.4"	"61.1"	"89.1"	"80.4"	"157.1"	"167.0"	"107.8"	"120.9"	"178.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q4G0J3"	"La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1"	"7"	"4"	"7"	"4"	"582"	"66.9"	"9.55"	"1138.24"	"11.65"	"3"	"4"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf05383, Pf08777"	"51574"	"ENSG00000174720"	"LARP7"	"B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"82.5"	"47.3"	"71.4"	"82.8"	"111.8"	"102.6"	"256.1"	"257.4"	"129.6"	"199.4"	"264.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62244"	"40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2"	"24"	"4"	"11"	"4"	"130"	"14.8"	"10.13"	"1621.26"	"11.65"	"4"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf00410"	"6210"	"ENSG00000134419"	"RPS15A"	"hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Response of EIF2AK4 (GCN2) to amino acid deficiency; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"392.2"	"317.4"	"440.7"	"529.1"	"648.6"	"566.8"	"1507.7"	"1390.6"	"838.4"	"1147.0"	"1449.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75521"	"Enoyl-CoA delta isomerase 2, mitochondrial OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4"	"10"	"3"	"5"	"3"	"394"	"43.6"	"9.00"	"515.01"	"11.62"	"2"	"3"	"other metabolic processes"	"cytosol;mitochondrion;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00378, Pf00887"	"10455"	"ENSG00000198721"	"ECI2"	"hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55"	""	""	"0"	"0"	"118.8"	"88.8"	"130.6"	"186.1"	"234.6"	"186.8"	"556.0"	"540.2"	"472.0"	"553.5"	"815.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6PKG0"	"La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2"	"6"	"5"	"9"	"5"	"1096"	"123.4"	"8.82"	"1178.37"	"11.60"	"4"	"5"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf05383"	"23367"	"ENSG00000155506"	"LARP1"	"hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7"	"Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway"	"SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"4"	"0"	"108.6"	"67.6"	"109.5"	"139.2"	"179.5"	"163.9"	"408.0"	"387.4"	"208.4"	"292.2"	"360.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14174"	"Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4"	"11"	"2"	"8"	"2"	"115"	"12.5"	"7.88"	"1425.63"	"11.44"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf01187"	"4282"	"ENSG00000240972; ENSG00000276701"	"MIF"	"A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0"	"Adipogenesis; Spinal cord injury"	"Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"	"5"	"0"	"276.2"	"251.5"	"288.4"	"271.9"	"352.9"	"343.7"	"526.6"	"471.6"	"232.6"	"486.7"	"889.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q05397"	"Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2"	"3"	"4"	"8"	"4"	"1052"	"119.2"	"6.62"	"1186.57"	"11.43"	"4"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function"	"Pf00373, Pf03623, Pf07714, Pf18038"	"5747"	"ENSG00000169398"	"PTK2"	"B4E2N6; F5H4S4; hsa:5747; J3QT16; Q05397; Q14291; Q8IYN9; Q9UD85"	"Androgen receptor signaling pathway; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Hippo-Merlin signaling dysregulation; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Small cell lung cancer; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q13 copy number variation syndrome; TROP2 regulatory signaling; A network map of Macrophage-stimulating protein (MSP) signaling; ErbB signaling pathway"	"RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Signal regulatory protein family interactions; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; MET activates PTK2 signaling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Apoptotic cleavage of cellular proteins"	"48"	"0"	"125.4"	"83.6"	"114.3"	"190.9"	"247.0"	"215.3"	"503.7"	"843.1"	"1132.9"	"1767.0"	"2221.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P42677"	"40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3"	"25"	"2"	"8"	"2"	"84"	"9.5"	"9.45"	"1169.19"	"11.40"	"2"	"2"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01667"	"6232"	"ENSG00000177954"	"RPS27"	"hsa:6232; P42677; Q5T4L6"	"Cytoplasmic ribosomal proteins"	"Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery"	"25"	"0"	"350.7"	"252.9"	"325.7"	"358.9"	"441.6"	"392.5"	"816.5"	"773.9"	"481.1"	"616.7"	"767.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NC96"	"Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2"	"15"	"4"	"9"	"4"	"275"	"29.7"	"6.80"	"1838.39"	"11.40"	"4"	"3"	"transport"	"plasma membrane;other membranes;cytosol;other cell component"	""	"Pf07933"	"25977"	"ENSG00000089818"	"NECAP1"	"hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407"	""	"Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis"	"3"	"0"	"83.2"	"60.2"	"87.3"	"118.9"	"175.1"	"139.2"	"436.8"	"917.2"	"1236.8"	"2025.8"	"2842.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63167"	"Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1"	"33"	"2"	"4"	"2"	"89"	"10.4"	"7.40"	"256.07"	"11.39"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf01221"	"8655"	"ENSG00000088986"	"DYNLL1"	"hsa:8655; P63167; Q15701"	"Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome"	"MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria"	"27"	"0"	"443.2"	"323.3"	"430.0"	"665.8"	"741.7"	"769.2"	"1188.2"	"1202.1"	"744.6"	"756.0"	"876.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15599"	"Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens OX=9606 GN=SLC9A3R2 PE=1 SV=2"	"8"	"2"	"4"	"2"	"337"	"37.4"	"7.93"	"1208.27"	"11.36"	"2"	"2"	"cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00595, Pf09007"	"9351"	"ENSG00000065054"	"NHERF2"	"D3DU84; D3DU85; H3BSV6; hsa:9351; O00272; O00556; Q15599; Q3KQY7"	""	""	"0"	"0"	"24.2"	"15.9"	"21.7"	"38.4"	"39.3"	"37.1"	"104.6"	"139.0"	"111.7"	"229.1"	"503.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96NB3"	"Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2"	"11"	"4"	"7"	"3"	"372"	"42.0"	"5.31"	"1022.80"	"11.35"	"3"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf12874"	"91603"	"ENSG00000198783"	"ZNF830"	"hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38"	"17q12 copy number variation syndrome"	"mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER"	"6"	"0"	"50.7"	"33.1"	"39.7"	"65.8"	"88.8"	"81.3"	"241.0"	"225.2"	"160.2"	"211.2"	"228.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95777"	"U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3"	"38"	"3"	"6"	"3"	"96"	"10.4"	"4.48"	"1214.51"	"11.34"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf01423"	"51691"	"ENSG00000128534"	"LSM8"	"hsa:51691; O95777"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"147.2"	"96.0"	"120.2"	"191.4"	"237.2"	"246.6"	"579.3"	"525.6"	"306.7"	"444.7"	"756.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60510"	"Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1"	"10"	"2"	"6"	"2"	"307"	"35.1"	"5.06"	"1020.34"	"11.32"	"2"	"2"	"DNA metabolism;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00149"	"5531"	"ENSG00000149923"	"PPP4C"	"hsa:5531; P33172; P60510"	"16p11.2 proximal deletion syndrome"	"Processing of DNA double-strand break ends"	"2"	"0"	"8.7"	"9.9"	"11.1"	"13.7"	"17.8"	"10.6"	"29.8"	"28.2"	"16.6"	"22.6"	"29.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NXW9"	"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1"	"18"	"4"	"8"	"4"	"302"	"33.8"	"6.67"	"1118.67"	"11.31"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"cytoskeletal activity;other molecular function"	""	"54784"	"ENSG00000160993"	"ALKBH4"	"hsa:54784; Q53H92; Q9H6A4; Q9NXW9"	""	""	"0"	"0"	"151.8"	"153.7"	"187.3"	"247.0"	"275.9"	"241.3"	"501.0"	"536.9"	"396.1"	"517.1"	"675.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NV70"	"Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4"	"4"	"4"	"7"	"4"	"894"	"101.9"	"6.61"	"1183.01"	"11.27"	"3"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf09763, Pf15277"	"55763"	"ENSG00000090989"	"EXOC1"	"hsa:55763; Q504V4; Q8WUE7; Q96T15; Q9NV70; Q9NZE4"	"Ciliary landscape"	"Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium"	"4"	"0"	"192.9"	"112.4"	"190.9"	"256.4"	"308.4"	"268.9"	"975.9"	"1366.5"	"993.9"	"1332.7"	"1680.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P17980"	"26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3"	"11"	"3"	"6"	"3"	"439"	"49.2"	"5.24"	"1430.36"	"11.27"	"3"	"3"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00004, Pf16450, Pf17862"	"5702"	"ENSG00000165916"	"PSMC3"	"B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"64"	"0"	"152.6"	"95.9"	"147.8"	"211.8"	"261.9"	"221.0"	"429.5"	"389.5"	"257.1"	"329.6"	"413.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92614"	"Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3"	"3"	"4"	"8"	"4"	"2054"	"233.0"	"6.30"	"1597.17"	"11.25"	"4"	"4"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes"	"other membranes;cytoskeleton;ER/Golgi;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00063, Pf01576, Pf17820"	"399687"	"ENSG00000196535"	"MYO18A"	"hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614"	""	"Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins"	"3"	"0"	"10.5"	"6.6"	"10.2"	"14.5"	"21.2"	"15.9"	"40.0"	"40.1"	"32.8"	"33.3"	"47.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P54725"	"UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1"	"15"	"4"	"6"	"2"	"363"	"39.6"	"4.58"	"993.78"	"11.25"	"3"	"3"	"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00240, Pf00627, Pf09280"	"5886"	"ENSG00000179262"	"RAD23A"	"hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1"	"Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER"	"6"	"2"	"354.9"	"243.0"	"321.3"	"485.0"	"614.9"	"575.1"	"879.0"	"851.5"	"638.1"	"774.7"	"1100.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15369"	"Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1"	"36"	"3"	"6"	"3"	"112"	"12.5"	"4.78"	"1106.32"	"11.24"	"3"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf03931"	"6921"	"ENSG00000154582"	"ELOC"	"E5RGD9; hsa:6921; Q15369; Q567Q6"	"Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2"	"Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling"	"21"	"0"	"57.8"	"61.4"	"58.6"	"82.8"	"94.8"	"96.9"	"129.2"	"144.2"	"140.6"	"157.0"	"193.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55081"	"Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2"	"12"	"5"	"8"	"4"	"439"	"51.9"	"4.98"	"1719.29"	"11.17"	"5"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"extracellular matrix;cytoskeleton;nucleus"	""	"Pf06991"	"4236"	"ENSG00000140259"	"MFAP1"	"hsa:4236; P55081; Q86TG6"	"Canonical and non-canonical Notch signaling; Ciliary landscape"	"mRNA Splicing - Major Pathway"	"3"	"0"	"301.6"	"173.2"	"254.1"	"377.9"	"468.8"	"432.2"	"1190.0"	"1123.5"	"730.7"	"1001.6"	"1294.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBQ5"	"Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1"	"17"	"4"	"7"	"4"	"218"	"25.0"	"4.93"	"1625.90"	"11.17"	"4"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"translation activity;nucleic acid binding activity"	"Pf10075"	"27335"	"ENSG00000178982; ENSG00000282986"	"EIF3K"	"A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1"	""	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"6"	"0"	"358.2"	"241.7"	"340.1"	"439.8"	"517.4"	"443.8"	"882.9"	"838.0"	"672.8"	"760.1"	"834.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P21333"	"Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4"	"2"	"4"	"7"	"3"	"2647"	"280.6"	"6.06"	"1008.01"	"11.16"	"3"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00307, Pf00630"	"2316"	"ENSG00000196924"	"FLNA"	"E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52"	"Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome"	"OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions"	"14"	"0"	"24.7"	"23.0"	"25.2"	"43.6"	"47.5"	"40.7"	"102.4"	"98.6"	"70.5"	"91.1"	"123.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2S6"	"Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1"	"36"	"4"	"12"	"3"	"64"	"7.1"	"9.99"	"2153.15"	"11.10"	"4"	"3"	""	""	""	"Pf09072"	"51372"	"ENSG00000232112"	"TMA7"	"hsa:51372; Q9P052; Q9Y2S6"	""	""	"0"	"2"	"460.9"	"365.2"	"353.5"	"379.0"	"538.3"	"512.6"	"3765.4"	"3723.4"	"4114.2"	"3324.4"	"4892.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BS26"	"Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1"	"16"	"7"	"12"	"6"	"406"	"46.9"	"5.26"	"2345.65"	"11.10"	"6"	"4"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;other membranes;ER/Golgi;other cell component"	"other molecular function"	"Pf00085, Pf13848"	"23071"	"ENSG00000023318"	"ERP44"	"hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26"	""	"Neutrophil degranulation"	"1"	"1"	"548.5"	"442.0"	"548.6"	"845.9"	"1012.5"	"977.3"	"1576.1"	"1692.4"	"1386.4"	"1732.3"	"2556.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2W2"	"WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1"	"6"	"3"	"5"	"3"	"641"	"70.0"	"8.38"	"926.10"	"11.08"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf09429"	"51729"	"ENSG00000084463"	"WBP11"	"hsa:51729; Q96AY8; Q9Y2W2"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"80.9"	"56.9"	"97.3"	"110.8"	"144.2"	"113.1"	"290.6"	"213.8"	"141.1"	"231.8"	"257.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9ULC4"	"Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1"	"27"	"3"	"5"	"3"	"181"	"20.5"	"8.82"	"902.57"	"11.05"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"other cell component"	"nucleic acid binding activity"	"Pf01472, Pf17832"	"28985"	"ENSG00000232119; ENSG00000288295"	"MCTS1"	"B4DGY2; hsa:28985; Q502X6; Q9ULC4"	""	""	"0"	"0"	"21.4"	"11.6"	"13.2"	"19.0"	"30.3"	"27.3"	"107.9"	"105.1"	"74.6"	"101.8"	"154.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P48444"	"Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1"	"10"	"4"	"8"	"4"	"511"	"57.2"	"6.21"	"1330.36"	"11.04"	"4"	"4"	"transport;developmental processes;other biological processes"	"other membranes;cytosol;ER/Golgi"	""	"Pf00928, Pf01217"	"372"	"ENSG00000095139"	"ARCN1"	"B4E1X2; E9PEU4; hsa:372; P48444; Q52M80"	"miR-517 relationship with ARCN1 and USP1"	"COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport"	"3"	"0"	"98.2"	"61.4"	"119.5"	"193.4"	"257.9"	"179.4"	"468.4"	"400.5"	"285.9"	"357.5"	"458.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BVP2"	"Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2"	"9"	"4"	"6"	"4"	"549"	"62.0"	"9.16"	"787.40"	"11.02"	"3"	"3"	"cell cycle OR cell proliferation;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01926, Pf08701"	"26354"	"ENSG00000163938"	"GNL3"	"B2RDC1; hsa:26354; Q5PU80; Q96SV6; Q96SV7; Q9BVP2; Q9UJY0"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"113.9"	"61.9"	"92.8"	"129.2"	"162.0"	"141.3"	"427.9"	"381.3"	"221.5"	"327.5"	"360.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRV9"	"Heme-binding protein 1 OS=Homo sapiens OX=9606 GN=HEBP1 PE=1 SV=1"	"16"	"3"	"7"	"3"	"189"	"21.1"	"5.80"	"1066.64"	"11.02"	"3"	"3"	"other biological processes"	"non-structural extracellular;other cell component"	"other molecular function"	"Pf04832"	"50865"	"ENSG00000013583"	"HEBP1"	"A8K1G2; hsa:50865; Q9NRV9; Q9Y5Z5"	""	"G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands"	"2"	"0"	"126.9"	"95.2"	"122.8"	"236.3"	"284.4"	"276.1"	"481.8"	"522.5"	"439.6"	"471.1"	"713.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NW64"	"Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1"	"10"	"4"	"8"	"4"	"420"	"46.9"	"8.54"	"1572.55"	"11.01"	"4"	"4"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"55696"	"ENSG00000086589"	"RBM22"	"A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"297.6"	"181.4"	"239.3"	"409.2"	"502.0"	"465.6"	"1415.8"	"1186.3"	"601.9"	"809.2"	"889.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95433"	"Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1"	"13"	"5"	"8"	"5"	"338"	"38.3"	"5.53"	"1223.65"	"10.99"	"4"	"4"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;ER/Golgi"	"other molecular function"	"Pf08327, Pf09229"	"10598"	"ENSG00000100591"	"AHSA1"	"B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060"	"T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection"	""	"1"	"0"	"389.4"	"309.5"	"459.9"	"504.7"	"628.2"	"478.5"	"851.1"	"871.2"	"705.4"	"742.2"	"1220.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UK45"	"U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1"	"72"	"5"	"8"	"5"	"103"	"11.6"	"5.27"	"882.86"	"10.97"	"3"	"5"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf01423"	"51690"	"ENSG00000130332"	"LSM7"	"hsa:51690; Q9UK45"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease"	"3"	"0"	"379.4"	"277.4"	"378.5"	"471.3"	"562.5"	"513.7"	"1357.1"	"1283.7"	"790.5"	"1052.6"	"1502.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22314"	"Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3"	"4"	"4"	"7"	"4"	"1058"	"117.8"	"5.76"	"1464.30"	"10.95"	"4"	"3"	"protein metabolism;other metabolic processes;stress response"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00899, Pf09358, Pf10585, Pf16190, Pf16191"	"7317"	"ENSG00000130985"	"UBA1"	"hsa:7317; P22314; Q5JRR8; Q96E13"	"Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway"	"Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation"	"5"	"0"	"249.0"	"174.3"	"258.9"	"267.0"	"355.7"	"404.7"	"535.9"	"481.8"	"304.8"	"498.7"	"745.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15143"	"Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3"	"12"	"3"	"5"	"2"	"372"	"40.9"	"8.35"	"688.23"	"10.94"	"2"	"3"	"cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00400"	"10095"	"ENSG00000130429"	"ARPC1B"	"hsa:10095; O15143; Q9BU00"	"Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling"	"6"	"0"	"34.6"	"26.3"	"31.7"	"36.1"	"49.1"	"59.6"	"144.0"	"167.5"	"145.7"	"177.9"	"418.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60866"	"40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1"	"19"	"2"	"6"	"2"	"119"	"13.4"	"9.94"	"1052.89"	"10.93"	"2"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00338"	"6224"	"ENSG00000008988"	"RPS20"	"B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery"	"19"	"0"	"101.3"	"55.1"	"107.4"	"112.6"	"170.9"	"133.5"	"405.6"	"379.4"	"247.2"	"322.5"	"343.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4Y9"	"U6 snRNA-associated Sm-like protein LSm5 OS=Homo sapiens OX=9606 GN=LSM5 PE=1 SV=3"	"25"	"1"	"2"	"1"	"91"	"9.9"	"4.54"	""	"10.92"	""	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01423"	"23658"	"ENSG00000106355"	"LSM5"	"hsa:23658; Q9Y4Y9"	""	"mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease"	"2"	"0"	"16.1"	"15.5"	"18.0"	"22.2"	"30.6"	"28.4"	"56.5"	"52.1"	"40.0"	"44.9"	"51.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P41250"	"Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3"	"5"	"3"	"5"	"2"	"739"	"83.1"	"7.03"	"603.98"	"10.92"	"2"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"non-structural extracellular;cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00458, Pf00587, Pf03129"	"2617"	"ENSG00000106105"	"GARS1"	"A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1"	""	"Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation"	"2"	"0"	"17.7"	"12.5"	"16.1"	"18.3"	"28.1"	"30.7"	"54.7"	"61.8"	"33.2"	"45.1"	"96.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BZ29"	"Dedicator of cytokinesis protein 9 OS=Homo sapiens OX=9606 GN=DOCK9 PE=1 SV=2"	"2"	"4"	"6"	"3"	"2069"	"236.3"	"7.49"	"696.11"	"10.92"	"2"	"4"	"signal transduction;other biological processes"	"cytosol;other cell component"	"enzyme regulator activity"	"Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422"	"23348"	"ENSG00000088387"	"DOCK9"	"B3KX25; E9PFM9; hsa:23348; Q5JUD4; Q5JUD6; Q5T2Q1; Q5TAN8; Q9BZ25; Q9BZ26; Q9BZ27; Q9BZ28; Q9BZ29; Q9UPU4"	""	"Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle"	"3"	"0"	"80.9"	"30.6"	"67.7"	"84.1"	"95.6"	"90.3"	"176.8"	"186.0"	"209.8"	"325.3"	"391.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NFW8"	"N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2"	"10"	"3"	"6"	"3"	"434"	"48.3"	"7.93"	"1171.37"	"10.91"	"3"	"3"	"other metabolic processes"	"nucleus"	"other molecular function"	"Pf02348"	"55907"	"ENSG00000111726"	"CMAS"	"hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0"	""	"Sialic acid metabolism"	"1"	"0"	"13.2"	"10.8"	"17.7"	"16.8"	"28.5"	"22.2"	"104.7"	"105.9"	"53.3"	"85.2"	"90.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75689"	"Arf-GAP with dual PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ADAP1 PE=1 SV=2"	"13"	"4"	"7"	"4"	"374"	"43.4"	"8.97"	"1292.85"	"10.90"	"4"	"3"	"signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00169, Pf01412"	"11033"	"ENSG00000105963"	"ADAP1"	"A4D2Q2; B3KRZ4; B4DVA6; F6XZ68; H7C2Q4; hsa:11033; O75689"	""	"Nuclear signaling by ERBB4"	"1"	"0"	"44.2"	"38.0"	"60.9"	"71.8"	"96.4"	"98.0"	"306.0"	"288.9"	"307.8"	"787.2"	"1277.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NFY9"	"Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2"	"7"	"4"	"7"	"4"	"601"	"68.8"	"6.29"	"1402.68"	"10.89"	"4"	"3"	"protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;other cell component"	""	"Pf00651, Pf01344, Pf07707"	"84541"	"ENSG00000163376"	"KBTBD8"	"B4DTW6; hsa:84541; Q8NFY9; Q96JI5"	""	"Antigen processing: Ubiquitination & Proteasome degradation; Neddylation"	"2"	"0"	"49.9"	"33.8"	"61.9"	"80.9"	"106.0"	"81.0"	"264.2"	"564.6"	"531.1"	"715.7"	"822.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UIL1"	"Short coiled-coil protein OS=Homo sapiens OX=9606 GN=SCOC PE=1 SV=2"	"18"	"2"	"6"	"2"	"159"	"18.0"	"8.85"	"1341.22"	"10.83"	"2"	"2"	"other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus"	""	"Pf10224"	"60592"	"ENSG00000153130"	"SCOC"	"B7WPH7; D3DNY7; E9PB65; hsa:60592; Q6P5T9; Q7L2Y0; Q7Z4P2; Q96JY9; Q9BZB2; Q9UIL1"	""	"Retrograde transport at the Trans-Golgi-Network"	"1"	"0"	"74.5"	"38.3"	"94.5"	"155.3"	"183.4"	"148.6"	"421.8"	"443.4"	"261.3"	"289.8"	"414.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q06330"	"Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3"	"8"	"4"	"7"	"4"	"500"	"55.6"	"7.18"	"904.84"	"10.82"	"3"	"4"	"cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf09270, Pf09271, Pf20144"	"3516"	"ENSG00000168214"	"RBPJ"	"B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3"	"Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway"	"Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Somitogenesis; Formation of paraxial mesoderm; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling"	"20"	"0"	"120.5"	"73.6"	"134.2"	"139.2"	"209.4"	"169.6"	"919.6"	"1105.8"	"590.7"	"911.2"	"1548.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16836"	"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3"	"11"	"3"	"6"	"3"	"314"	"34.3"	"8.85"	"678.51"	"10.79"	"2"	"3"	"other metabolic processes;other biological processes"	"mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00725, Pf02737"	"3033"	"ENSG00000138796"	"HADH"	"hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4"	"Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders"	"Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"	"11"	"0"	"20.9"	"13.2"	"25.2"	"23.2"	"33.0"	"36.1"	"107.3"	"125.5"	"58.8"	"115.3"	"204.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y277"	"Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3 PE=1 SV=1"	"17"	"4"	"6"	"3"	"283"	"30.6"	"8.66"	"580.91"	"10.78"	"2"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf01459"	"7419"	"ENSG00000078668"	"VDAC3"	"hsa:7419; Q9UIS0; Q9Y277"	"Alzheimer's disease and miRNA effects; Ferroptosis; Hepatitis B infection; Alzheimer's disease"	"Ub-specific processing proteases; Mitochondrial calcium ion transport"	"6"	"0"	"54.0"	"30.9"	"45.9"	"56.7"	"91.6"	"75.5"	"146.6"	"124.4"	"65.9"	"113.7"	"151.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62993"	"Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1"	"17"	"3"	"6"	"3"	"217"	"25.2"	"6.32"	"1097.88"	"10.78"	"3"	"3"	"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00017, Pf00018"	"2885"	"ENSG00000177885"	"GRB2"	"hsa:2885; P29354; P62993; Q14450; Q63057; Q63059"	"IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; A network map of Macrophage-stimulating protein (MSP) signaling; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)"	"Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling"	"68"	"0"	"286.5"	"206.3"	"292.1"	"421.8"	"465.6"	"460.0"	"729.3"	"764.1"	"534.5"	"664.1"	"1002.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60508"	"Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1"	"6"	"3"	"6"	"3"	"579"	"65.5"	"7.06"	"1235.22"	"10.73"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes;developmental processes"	"nucleus"	"nucleic acid binding activity"	"Pf00400"	"51362"	"ENSG00000168438"	"CDC40"	"B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1"	"mRNA processing"	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway"	"5"	"0"	"114.4"	"56.9"	"91.9"	"135.1"	"170.7"	"154.6"	"562.5"	"508.0"	"324.8"	"469.4"	"585.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A8MWD9"	"Putative small nuclear ribonucleoprotein G-like protein 15 OS=Homo sapiens OX=9606 GN=SNRPGP15 PE=5 SV=2"	"28"	"4"	"8"	"4"	"76"	"8.5"	"8.84"	"1555.42"	"10.70"	"3"	"4"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf01423"	""	""	"SNRPGP15"	"A8MWD9"	""	""	"0"	"0"	"283.0"	"146.0"	"211.5"	"259.9"	"355.6"	"281.9"	"890.5"	"870.6"	"545.9"	"684.2"	"1046.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UNE7"	"E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2"	"17"	"5"	"9"	"5"	"303"	"34.8"	"5.87"	"1749.84"	"10.68"	"5"	"4"	"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf04564, Pf12895, Pf18391"	"10273"	"ENSG00000103266"	"STUB1"	"A2IDB9; hsa:10273; O60526; Q969U2; Q9HBT1; Q9UNE7"	"Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway"	"Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Regulation of TNFR1 signaling; Downregulation of TGF-beta receptor signaling"	"10"	"0"	"128.0"	"102.9"	"151.1"	"200.3"	"239.0"	"200.6"	"859.1"	"822.1"	"616.7"	"600.5"	"588.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75955"	"Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3"	"7"	"2"	"6"	"2"	"427"	"47.3"	"7.49"	"1301.97"	"10.68"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf01145"	"10211"	"ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280"	"FLOT1"	"B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8"	"Angiopoietin-like protein 8 regulatory pathway; Insulin signaling"	"RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules"	"8"	"0"	"66.5"	"50.0"	"72.1"	"78.8"	"103.3"	"95.3"	"182.2"	"175.4"	"107.3"	"166.0"	"249.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15287"	"RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1"	"7"	"2"	"6"	"2"	"305"	"34.2"	"11.84"	"1021.50"	"10.59"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"10921"	"ENSG00000205937"	"RNPS1"	"A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3"	"mRNA processing"	"mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"7"	"0"	"107.6"	"82.8"	"108.1"	"123.5"	"198.4"	"157.1"	"410.3"	"355.7"	"314.8"	"712.3"	"764.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19525"	"Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2"	"5"	"2"	"6"	"2"	"551"	"62.1"	"8.40"	"1130.29"	"10.58"	"2"	"2"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function"	"Pf00035, Pf00069"	"5610"	"ENSG00000055332"	"EIF2AK2"	"A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4"	"Translation factors; Alzheimer's disease and miRNA effects; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling"	"ISG15 antiviral mechanism; Interferon alpha/beta signaling; Inhibition of PKR"	"12"	"0"	"24.8"	"16.1"	"35.0"	"36.8"	"48.7"	"44.3"	"204.2"	"204.7"	"101.5"	"156.2"	"197.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IWX8"	"Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3"	"4"	"5"	"9"	"5"	"916"	"103.6"	"9.04"	"1396.37"	"10.58"	"5"	"4"	"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf01585, Pf01805, Pf04818"	"10523"	"ENSG00000085872"	"CHERP"	"hsa:10523; O00302; Q4G0Y5; Q8IWX8; Q8WU30; Q99492"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"465.3"	"378.4"	"445.5"	"589.4"	"728.6"	"579.8"	"1073.0"	"1023.1"	"631.7"	"834.1"	"936.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14558"	"Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2"	"14"	"4"	"7"	"2"	"356"	"39.4"	"7.20"	"1226.72"	"10.57"	"4"	"3"	"other metabolic processes"	"other cell component"	"enzyme regulator activity;other molecular function"	"Pf13793, Pf14572"	"5635"	"ENSG00000161542"	"PRPSAP1"	"B2R6M4; hsa:5635; Q14558; Q96H06"	""	""	"0"	"0"	"8.0"	"3.8"	"7.8"	"11.3"	"21.2"	"13.9"	"29.8"	"27.8"	"18.3"	"22.9"	"37.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62861"	"40S ribosomal protein S30 OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1"	"19"	"2"	"6"	"2"	"59"	"6.6"	"12.15"	"590.09"	"10.57"	"2"	"2"	"protein metabolism;other metabolic processes;stress response"	"non-structural extracellular;cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf04758"	""	"ENSCHIG00000017446; ENSJHYG00000000624; ENSLLEG00000000574"	"Fau; FAU"	"A0A452F0A8; A0A7L0YXB0; A0A8C5IE60; A0A8C5LQJ8; P0C2F0; P62860; P62863; P62864; P62866; P62867; Q05472; Q5RC12; Q8HYI8; Q920W7; Q95261"	""	""	"0"	"0"	"205.9"	"161.9"	"169.1"	"187.0"	"234.2"	"201.9"	"540.7"	"509.8"	"406.5"	"436.8"	"457.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62873"	"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3"	"12"	"3"	"5"	"2"	"340"	"37.4"	"6.00"	"676.33"	"10.54"	"2"	"3"	"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf00400"	"2782"	"ENSG00000078369"	"GNB1"	"B1AJZ7; hsa:2782; P04697; P04901; P62873; Q1RMY8"	"Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; 1p36 copy number variation syndrome; Calcium regulation in cardiac cells; Estrogen signaling pathway"	"G alpha (q) signalling events; G alpha (12/13) signalling events; Olfactory Signaling Pathway; G alpha (i) signalling events; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Inactivation, recovery and regulation of the phototransduction cascade; Glucagon signaling in metabolic regulation; Activation of the phototransduction cascade"	"45"	"1"	"94.6"	"65.3"	"72.5"	"91.5"	"108.5"	"92.5"	"203.4"	"191.7"	"128.0"	"207.3"	"297.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20618"	"Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2"	"8"	"1"	"6"	"1"	"241"	"26.5"	"8.13"	"1181.07"	"10.53"	"1"	"1"	"protein metabolism;other metabolic processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	""	"Pf00227"	"5689"	"ENSG00000008018"	"PSMB1"	"B5BU76; hsa:5689; P20618; Q9BWA8"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"63"	"0"	"45.5"	"31.7"	"49.0"	"53.0"	"72.0"	"66.9"	"161.3"	"159.4"	"117.9"	"136.3"	"150.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13442"	"28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1"	"29"	"4"	"9"	"4"	"181"	"20.6"	"8.87"	"2726.07"	"10.48"	"4"	"3"	"signal transduction"	"non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component"	""	"Pf10252"	"11333"	"ENSG00000106244"	"PDAP1"	"D6W5S5; hsa:11333; Q13442; Q92906"	""	"Neutrophil degranulation"	"1"	"0"	"401.6"	"255.4"	"359.2"	"436.0"	"542.7"	"460.6"	"2182.9"	"1939.1"	"1497.9"	"1625.0"	"1883.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BWJ5"	"Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1"	"28"	"2"	"6"	"2"	"86"	"10.1"	"6.35"	"1032.96"	"10.44"	"2"	"2"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf07189"	"83443"	"ENSG00000169976"	"SF3B5"	"B2R568; hsa:83443; Q7RTV1; Q9BWJ5"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"104.3"	"57.3"	"98.2"	"114.8"	"143.4"	"131.0"	"374.6"	"406.1"	"220.8"	"291.2"	"333.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P59998"	"Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3"	"22"	"4"	"8"	"4"	"168"	"19.7"	"8.43"	"1268.63"	"10.44"	"4"	"4"	"cell organization and biogenesis"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf05856"	"10093"	"ENSG00000241553"	"ARPC4"	"C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3"	"Pathogenic Escherichia coli infection"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling"	"6"	"0"	"112.7"	"73.8"	"97.4"	"123.0"	"168.3"	"160.3"	"464.7"	"619.7"	"448.3"	"694.6"	"2057.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49588"	"Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2"	"3"	"3"	"8"	"3"	"968"	"106.7"	"5.53"	"1075.32"	"10.42"	"3"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;mitochondrion;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01411, Pf02272, Pf07973"	"16"	"ENSG00000090861"	"AARS1"	"A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0"	"IL-18 signaling pathway"	"Cytosolic tRNA aminoacylation"	"2"	"0"	"124.8"	"99.0"	"136.3"	"196.3"	"237.3"	"208.2"	"487.2"	"441.4"	"264.8"	"402.6"	"544.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14974"	"Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2"	"3"	"3"	"6"	"3"	"876"	"97.1"	"4.78"	"1206.39"	"10.40"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes"	"non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00514, Pf03810"	"3837"	"ENSG00000108424"	"KPNB1"	"B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27"	"Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome"	"Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production"	"15"	"0"	"374.7"	"199.8"	"286.1"	"439.4"	"513.5"	"424.3"	"870.0"	"856.2"	"423.8"	"659.5"	"746.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14978"	"Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2"	"7"	"5"	"9"	"5"	"699"	"73.6"	"9.47"	"1701.05"	"10.38"	"5"	"4"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf05022"	"9221"	"ENSG00000166197"	"NOLC1"	"hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3"	""	""	"0"	"0"	"141.1"	"58.8"	"107.0"	"132.6"	"172.4"	"152.0"	"1036.6"	"833.6"	"442.9"	"476.4"	"780.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WXH0"	"Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3"	"1"	"5"	"8"	"4"	"6885"	"795.9"	"5.36"	"1280.26"	"10.36"	"4"	"4"	"cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf00435, Pf10541"	"23224"	"ENSG00000054654"	"SYNE2"	"B4DND7; B4DPR6; hsa:23224; I6XXQ5; Q540G1; Q86YP9; Q8N1S3; Q8NF49; Q8TER7; Q8WWW3; Q8WWW4; Q8WWW5; Q8WXH0; Q8WXH1; Q9NU50; Q9UFQ4; Q9Y2L4; Q9Y4R1"	"Ovarian infertility; Rett syndrome causing genes; Envelope proteins and their potential roles in EDMD physiopathology"	"Meiotic synapsis"	"4"	"1"	"109.0"	"80.6"	"107.4"	"150.4"	"198.4"	"145.0"	"499.4"	"440.4"	"231.2"	"334.4"	"457.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13283"	"Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1"	"8"	"3"	"6"	"3"	"466"	"52.1"	"5.52"	"971.36"	"10.35"	"3"	"3"	"cell organization and biogenesis;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00076, Pf02136"	"10146"	"ENSG00000145907"	"G3BP1"	"hsa:10146; Q13283; Q5HYE9"	""	"SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"1"	"0"	"54.5"	"40.5"	"52.2"	"64.8"	"81.0"	"68.4"	"177.6"	"178.6"	"122.7"	"161.2"	"194.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15530"	"3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1"	"6"	"2"	"6"	"2"	"556"	"63.1"	"7.36"	"1207.07"	"10.30"	"2"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"enzyme regulator activity;kinase activity;other molecular function"	"Pf00069, Pf14593"	"5170"	"ENSG00000140992"	"PDPK1"	"H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5"	"MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; A network map of Macrophage-stimulating protein (MSP) signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway"	"Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways"	"46"	"0"	"3.4"	"3.2"	"5.6"	"10.9"	"8.3"	"15.7"	"25.2"	"19.9"	"12.7"	"23.6"	"33.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P36954"	"DNA-directed RNA polymerase II subunit RPB9 OS=Homo sapiens OX=9606 GN=POLR2I PE=1 SV=1"	"24"	"3"	"4"	"3"	"125"	"14.5"	"5.14"	"371.33"	"10.30"	"1"	"3"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01096, Pf02150"	"5438"	"ENSG00000105258"	"POLR2I"	"B2R5J2; hsa:5438; P36954; Q6NW05"	"Pyrimidine metabolism; Eukaryotic transcription initiation"	"mRNA Splicing - Major Pathway; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Inhibition of DNA recombination at telomere; PIWI-interacting RNA (piRNA) biogenesis; Processing of Capped Intron-Containing Pre-mRNA; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; MicroRNA (miRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM"	"43"	"0"	"126.4"	"104.8"	"151.3"	"183.5"	"243.2"	"205.0"	"551.4"	"554.9"	"456.7"	"567.4"	"549.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15145"	"Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3"	"24"	"4"	"6"	"4"	"178"	"20.5"	"8.59"	"1159.25"	"10.29"	"3"	"3"	"cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity"	"Pf04062"	"10094"	"ENSG00000111229"	"ARPC3"	"hsa:10094; O00554; O15145"	"Pathogenic Escherichia coli infection"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling"	"6"	"0"	"106.5"	"68.5"	"100.2"	"131.2"	"175.8"	"161.5"	"624.6"	"851.1"	"703.0"	"1015.5"	"2513.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P27694"	"Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2"	"12"	"6"	"10"	"6"	"616"	"68.1"	"7.21"	"2445.47"	"10.23"	"6"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01336, Pf04057, Pf08646, Pf16900"	"6117"	"ENSG00000132383"	"RPA1"	"A8K0Y9; hsa:6117; P27694; Q59ES9"	"Homologous recombination; Retinoblastoma gene in cancer; ATR signaling; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair"	"SUMOylation of DNA damage response and repair proteins; PCNA-Dependent Long Patch Base Excision Repair; Regulation of HSF1-mediated heat shock response; Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"	"39"	"0"	"395.8"	"229.8"	"378.9"	"477.3"	"556.8"	"552.4"	"900.4"	"865.6"	"523.9"	"740.4"	"1073.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52298"	"Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1"	"23"	"3"	"6"	"3"	"156"	"18.0"	"8.21"	"1050.80"	"10.22"	"3"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"22916"	"ENSG00000114503"	"NCBP2"	"B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50"	"mRNA processing; 3q29 copy number variation syndrome"	"Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"	"29"	"0"	"251.0"	"166.1"	"228.9"	"274.8"	"340.7"	"294.9"	"847.1"	"826.9"	"451.9"	"752.3"	"1046.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52294"	"Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3"	"6"	"3"	"5"	"3"	"538"	"60.2"	"5.01"	"831.95"	"10.22"	"2"	"3"	"cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00514, Pf01749, Pf16186"	"3836"	"ENSG00000114030"	"KPNA1"	"D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56"	"Ebola virus infection in host"	"ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production"	"10"	"0"	"81.9"	"52.1"	"84.2"	"111.5"	"152.0"	"119.9"	"355.5"	"346.6"	"221.3"	"271.3"	"392.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46779"	"60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3"	"19"	"3"	"8"	"3"	"137"	"15.7"	"12.02"	"1413.86"	"10.19"	"3"	"3"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf01778"	"6158"	"ENSG00000108107"	"RPL28"	"B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"201.9"	"122.9"	"158.5"	"228.8"	"275.0"	"240.1"	"1136.6"	"1032.6"	"580.9"	"787.5"	"1161.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96EE3"	"Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3"	"11"	"2"	"3"	"2"	"360"	"39.6"	"8.09"	"399.93"	"10.18"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes"	"other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00400"	"81929"	"ENSG00000085415"	"SEH1L"	"A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069"	""	"Amino acids regulate mTORC1"	"1"	"0"	"42.2"	"17.6"	"28.4"	"50.6"	"49.1"	"51.3"	"110.5"	"97.6"	"79.0"	"96.3"	"106.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14936"	"Peripheral plasma membrane protein CASK OS=Homo sapiens OX=9606 GN=CASK PE=1 SV=3"	"5"	"4"	"7"	"4"	"926"	"105.1"	"6.43"	"1419.19"	"10.16"	"4"	"3"	"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes"	"extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;kinase activity;other molecular function"	"Pf00018, Pf00069, Pf00595, Pf00625, Pf02828"	"8573"	"ENSG00000147044"	"CASK"	"A6NES1; B7ZKY0; hsa:8573; O14936; O43215; Q17RI4; Q59HA0; Q5VT16; Q5VT17; Q5VT18; Q5VT19; Q66T42; Q9BYH6; Q9NYB2; Q9NYB3"	"Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins"	"Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions"	"9"	"0"	"110.7"	"78.4"	"137.7"	"186.5"	"228.3"	"204.2"	"399.5"	"418.9"	"238.7"	"330.6"	"399.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKF6"	"Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1"	"7"	"5"	"8"	"5"	"684"	"77.4"	"5.60"	"1204.24"	"10.15"	"3"	"4"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00753, Pf07521, Pf10996, Pf11718"	"51692"	"ENSG00000119203"	"CPSF3"	"hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6"	"mRNA processing"	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; Processing of Intronless Pre-mRNAs"	"6"	"0"	"295.3"	"187.3"	"282.5"	"471.2"	"552.1"	"445.1"	"982.5"	"924.8"	"515.3"	"721.7"	"871.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BWF3"	"RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1"	"12"	"4"	"7"	"4"	"364"	"40.3"	"7.08"	"1442.98"	"10.12"	"4"	"3"	"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf00098"	"5936"	"ENSG00000173933"	"RBM4"	"B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3"	""	"Circadian Clock"	"1"	"0"	"219.7"	"154.5"	"201.8"	"323.4"	"372.2"	"322.5"	"858.6"	"802.5"	"496.2"	"647.0"	"702.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09622"	"Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2"	"8"	"4"	"7"	"4"	"509"	"54.1"	"7.85"	"1396.20"	"10.11"	"4"	"3"	"protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf02852, Pf07992"	"1738"	"ENSG00000091140"	"DLD"	"B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4"	"Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)"	"Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Glycine degradation"	"18"	"0"	"233.5"	"143.6"	"228.1"	"311.8"	"367.1"	"327.9"	"980.5"	"990.1"	"565.2"	"836.9"	"1283.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NUQ3"	"Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2"	"9"	"4"	"6"	"3"	"528"	"60.5"	"7.52"	"945.45"	"10.11"	"3"	"3"	"cell cycle OR cell proliferation;other biological processes"	"other membranes;cytosol;nucleus"	"other molecular function"	"Pf09728"	"55787"	"ENSG00000086712"	"TXLNG"	"hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1"	""	""	"0"	"0"	"55.0"	"35.1"	"66.0"	"74.9"	"83.8"	"70.2"	"275.6"	"279.2"	"210.9"	"252.6"	"364.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99575"	"Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2"	"3"	"3"	"6"	"3"	"1024"	"114.6"	"9.22"	"575.14"	"10.11"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf06978, Pf08170"	"10940"	"ENSG00000104356"	"POP1"	"A8K5W9; hsa:10940; Q15037; Q99575"	""	"tRNA processing in the nucleus"	"1"	"0"	"209.7"	"53.5"	"167.2"	"323.5"	"456.1"	"307.7"	"1429.7"	"1536.1"	"166.1"	"275.1"	"686.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60828"	"Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1"	"23"	"4"	"6"	"4"	"265"	"30.5"	"6.33"	"1362.15"	"10.07"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	""	"10084"	"ENSG00000102103"	"PQBP1"	"C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"248.8"	"149.5"	"243.1"	"271.0"	"370.3"	"302.8"	"794.3"	"744.1"	"492.2"	"595.7"	"812.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BW27"	"Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1"	"6"	"3"	"5"	"3"	"656"	"75.0"	"5.55"	"718.62"	"10.05"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf07575"	"79902"	"ENSG00000125450"	"NUP85"	"B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1"	""	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation"	"35"	"0"	"74.2"	"56.1"	"79.1"	"152.0"	"160.5"	"140.3"	"291.4"	"293.3"	"174.6"	"236.6"	"231.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43920"	"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 OS=Homo sapiens OX=9606 GN=NDUFS5 PE=1 SV=3"	"40"	"4"	"6"	"4"	"106"	"12.5"	"9.14"	"955.49"	"10.04"	"3"	"3"	"cell organization and biogenesis;other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity"	"Pf10200"	"4725"	"ENSG00000168653"	"NDUFS5"	"hsa:4725; O43920"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"5"	"0"	"132.5"	"89.5"	"129.3"	"152.3"	"202.0"	"171.7"	"1006.7"	"987.1"	"725.4"	"856.4"	"792.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60568"	"Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1"	"5"	"3"	"6"	"3"	"738"	"84.7"	"6.05"	"1116.32"	"10.03"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"non-structural extracellular;extracellular matrix;other membranes;ER/Golgi"	"other molecular function"	"Pf03171"	"8985"	"ENSG00000106397"	"PLOD3"	"B2R6W6; hsa:8985; O60568; Q540C3"	"VEGFA-VEGFR2 signaling; IL-18 signaling pathway"	"Collagen biosynthesis and modifying enzymes"	"3"	"0"	"100.3"	"81.7"	"109.6"	"140.1"	"178.7"	"157.4"	"363.1"	"382.4"	"220.7"	"285.9"	"447.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3B4"	"Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1"	"15"	"2"	"7"	"2"	"125"	"14.6"	"9.38"	"1327.34"	"9.99"	"2"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076"	"51639"	"ENSG00000115128"	"SF3B6"	"hsa:51639; Q53TM1; Q9Y3B4"	""	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"2"	"0"	"197.4"	"107.0"	"185.6"	"207.5"	"303.3"	"256.2"	"878.4"	"696.2"	"455.9"	"738.1"	"972.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00273"	"DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1"	"12"	"3"	"6"	"3"	"331"	"36.5"	"4.79"	"921.56"	"9.96"	"3"	"3"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf02017, Pf09033"	"1676"	"ENSG00000160049"	"DFFA"	"hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6"	"Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis"	"Apoptosis induced DNA fragmentation"	"4"	"0"	"81.5"	"68.6"	"79.8"	"131.4"	"167.3"	"146.2"	"212.6"	"228.9"	"143.3"	"203.8"	"261.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NX58"	"Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=2"	"9"	"3"	"5"	"3"	"379"	"43.6"	"9.54"	"774.18"	"9.94"	"2"	"3"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"109.7"	"76.2"	"131.2"	"155.8"	"194.9"	"139.3"	"522.5"	"482.6"	"288.1"	"394.5"	"483.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14136"	"Glial fibrillary acidic protein OS=Homo sapiens OX=9606 GN=GFAP PE=1 SV=1"	"8"	"3"	"6"	"1"	"432"	"49.9"	"5.52"	"781.14"	"9.91"	"1"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00038, Pf04732"	"2670"	"ENSG00000131095"	"GFAP"	"A7REI1; B2RD44; D3DX59; E9PAX3; hsa:2670; P14136; Q53H98; Q5D055; Q6ZQS3; Q7Z5J6; Q7Z5J7; Q96KS4; Q96P18; Q9UFD0"	"Neural crest differentiation; Spinal cord injury; Neuroinflammation and glutamatergic signaling"	"Chaperone Mediated Autophagy; Nuclear signaling by ERBB4"	"5"	"0"	"9.5"	"11.9"	"11.0"	"17.4"	"19.3"	"15.6"	"23.1"	"29.7"	"54.1"	"32.7"	"48.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12694"	"2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2"	"9"	"3"	"5"	"3"	"445"	"50.4"	"8.27"	"717.84"	"9.89"	"2"	"3"	"other metabolic processes"	"mitochondrion"	"other molecular function"	"Pf00676"	"593"	"ENSG00000248098"	"BCKDHA"	"B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472"	"Lipid metabolism pathway"	"Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism"	"3"	"0"	"72.5"	"67.6"	"77.6"	"103.9"	"116.5"	"109.3"	"216.1"	"246.3"	"160.0"	"195.3"	"268.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TDN4"	"CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens OX=9606 GN=CABLES1 PE=1 SV=2"	"6"	"3"	"6"	"3"	"633"	"67.6"	"9.17"	"1176.10"	"9.87"	"3"	"3"	"cell cycle OR cell proliferation;developmental processes;other biological processes"	"cytosol;nucleus"	""	"Pf00134"	"91768"	"ENSG00000134508"	"CABLES1"	"B4DK60; hsa:91768; Q8N3Y8; Q8NA22; Q8TDN4; Q9BTG1"	""	"Factors involved in megakaryocyte development and platelet production; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry"	"3"	"0"	"15.8"	"11.5"	"20.6"	"24.9"	"29.8"	"22.2"	"78.1"	"136.1"	"106.5"	"168.7"	"215.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BZK7"	"F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1"	"6"	"3"	"5"	"3"	"514"	"55.6"	"5.55"	"846.36"	"9.87"	"2"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00400, Pf08513"	"79718"	"ENSG00000177565"	"TBL1XR1"	"D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1"	"Rett syndrome causing genes"	"HCMV Early Events; HDACs deacetylate histones; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Loss of MECP2 binding ability to the NCoR/SMRT complex; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression"	"20"	"0"	"108.4"	"83.3"	"124.4"	"221.4"	"278.2"	"258.5"	"370.8"	"390.8"	"256.2"	"333.5"	"454.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96SB8"	"Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2"	"4"	"3"	"5"	"3"	"1091"	"126.2"	"6.99"	"796.54"	"9.85"	"2"	"3"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02463"	"79677"	"ENSG00000163029"	"SMC6"	"A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0"	""	"SUMOylation of DNA damage response and repair proteins"	"1"	"0"	"32.0"	"11.3"	"28.6"	"37.7"	"39.4"	"36.0"	"158.6"	"141.6"	"87.8"	"128.7"	"132.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q06265"	"Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3"	"9"	"3"	"5"	"3"	"439"	"48.9"	"5.29"	"786.66"	"9.84"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01138, Pf03725"	"5393"	"ENSG00000123737"	"EXOSC9"	"hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48"	"Ciliary landscape"	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"7"	"0"	"56.8"	"40.4"	"67.8"	"91.2"	"105.0"	"96.4"	"222.2"	"222.8"	"152.6"	"194.2"	"269.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35244"	"Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1"	"31"	"3"	"6"	"3"	"121"	"13.6"	"5.08"	"1163.97"	"9.82"	"3"	"3"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf08661"	"6119"	"ENSG00000106399"	"RPA3"	"hsa:6119; P35244; Q549U6"	"Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair"	"Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"	"36"	"0"	"55.0"	"28.9"	"52.4"	"59.3"	"82.4"	"82.0"	"138.1"	"134.1"	"87.3"	"104.6"	"163.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86SX6"	"Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2"	"20"	"3"	"8"	"3"	"157"	"16.6"	"6.79"	"1015.68"	"9.81"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00462"	"51218"	"ENSG00000182512"	"GLRX5"	"hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54"	"Iron-sulfur cluster biogenesis"	"Mitochondrial iron-sulfur cluster biogenesis"	"2"	"0"	"148.7"	"110.9"	"142.2"	"212.8"	"253.4"	"224.0"	"360.6"	"362.8"	"258.9"	"292.6"	"422.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y224"	"RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1"	"20"	"4"	"7"	"4"	"244"	"28.1"	"6.65"	"1406.93"	"9.80"	"4"	"2"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf10036"	"51637"	"ENSG00000087302"	"RTRAF"	"hsa:51637; Q9Y224"	""	"tRNA processing in the nucleus"	"1"	"0"	"169.2"	"101.5"	"143.4"	"183.1"	"253.3"	"199.7"	"841.3"	"752.8"	"452.8"	"557.7"	"858.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N163"	"Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2"	"4"	"3"	"6"	"3"	"923"	"102.8"	"5.22"	"850.81"	"9.78"	"3"	"3"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"cytoskeleton;mitochondrion;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf14443, Pf14444, Pf19256, Pf19257"	"57805"	"ENSG00000158941"	"CCAR2"	"A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55"	"TAR syndrome"	"Regulation of HSF1-mediated heat shock response"	"2"	"0"	"51.5"	"42.0"	"59.2"	"89.7"	"109.4"	"77.2"	"135.6"	"135.0"	"77.6"	"122.1"	"146.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15022"	"Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3"	"3"	"1"	"4"	"1"	"739"	"83.0"	"8.81"	"814.52"	"9.78"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf09733"	"23512"	"ENSG00000178691"	"SUZ12"	"hsa:23512; Q15022; Q96BD9"	"Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma"	"HCMV Early Events; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; PKMTs methylate histone lysines; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6"	"14"	"0"	"16.6"	"7.2"	"17.9"	"23.0"	"26.5"	"23.5"	"53.3"	"62.0"	"29.5"	"44.5"	"59.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62899"	"60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1"	"18"	"2"	"6"	"2"	"125"	"14.5"	"10.54"	"1014.89"	"9.78"	"2"	"2"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf01198"	"6160"	"ENSG00000071082"	"RPL31"	"B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"144.6"	"91.4"	"140.3"	"147.6"	"173.2"	"193.5"	"699.0"	"628.3"	"407.8"	"562.1"	"662.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P32929"	"Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3"	"9"	"3"	"6"	"3"	"405"	"44.5"	"6.70"	"966.47"	"9.77"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf01053"	"1491"	"ENSG00000116761"	"CTH"	"B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8"	"Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis"	"Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine"	"11"	"0"	"54.3"	"41.9"	"69.6"	"79.0"	"77.2"	"72.8"	"139.0"	"141.7"	"90.4"	"98.9"	"156.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRP8"	"Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1"	"23"	"3"	"6"	"3"	"204"	"22.6"	"9.45"	"926.13"	"9.76"	"3"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"translation activity"	"Pf09282"	"84305"	"ENSG00000170473"	"PYM1"	"B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8"	"TAR syndrome"	""	"1"	"0"	"57.3"	"41.0"	"54.0"	"63.8"	"76.9"	"77.0"	"242.9"	"237.8"	"188.9"	"246.8"	"303.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13554"	"Calcium/calmodulin-dependent protein kinase type II subunit beta OS=Homo sapiens OX=9606 GN=CAMK2B PE=1 SV=3"	"6"	"3"	"6"	"1"	"666"	"72.6"	"7.27"	"1120.92"	"9.71"	"3"	"3"	"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"cytoskeletal activity;kinase activity;other molecular function"	"Pf00069, Pf08332"	"816"	"ENSG00000058404"	"CAMK2B"	"A4D2K0; A4D2K1; A4D2K2; A4D2K3; A4D2K4; A4D2K5; A4D2K6; hsa:816; O95437; O95438; O95599; Q13554; Q9UGH7; Q9UGH8; Q9UGH9; Q9UNX0; Q9UNX7; Q9UP00; Q9Y5N4; Q9Y6F4"	"Primary focal segmental glomerulosclerosis (FSGS); Myometrial relaxation and contraction pathways; Serotonin and anxiety; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Calcium regulation in cardiac cells; ErbB signaling pathway"	"Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"	"35"	"2"	"35.2"	"20.8"	"38.2"	"59.5"	"64.8"	"58.0"	"118.5"	"119.3"	"66.6"	"91.6"	"119.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q04637"	"Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4"	"3"	"4"	"7"	"4"	"1599"	"175.4"	"5.33"	"1078.28"	"9.70"	"3"	"4"	"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02020, Pf02847, Pf02854"	"1981"	"ENSG00000114867"	"EIF4G1"	"D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102"	"Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma"	"AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Ribosomal scanning and start codon recognition; Deadenylation of mRNA; ISG15 antiviral mechanism; mTORC1-mediated signalling"	"18"	"0"	"43.1"	"27.9"	"28.3"	"51.4"	"56.8"	"59.7"	"133.6"	"104.7"	"80.1"	"112.8"	"121.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14910"	"Protein lin-7 homolog A OS=Homo sapiens OX=9606 GN=LIN7A PE=1 SV=2"	"14"	"4"	"9"	"1"	"233"	"26.0"	"8.72"	"1455.42"	"9.69"	"4"	"3"	"cell-cell signaling;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;other cell component"	"other molecular function"	"Pf00595, Pf02828"	"8825"	"ENSG00000111052"	"LIN7A"	"A4FTY3; hsa:8825; O14910; Q147W1; Q6LES3; Q7LDS4"	""	"Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle"	"3"	"0"	"57.3"	"39.9"	"62.6"	"75.6"	"106.9"	"93.9"	"203.7"	"190.8"	"124.9"	"149.0"	"179.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49959"	"Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3"	"4"	"2"	"6"	"2"	"708"	"80.5"	"5.90"	"1177.48"	"9.66"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00149, Pf04152"	"4361"	"ENSG00000020922"	"MRE11"	"B3KTC7; hsa:4361; O43475; P49959"	"miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response"	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN"	"32"	"0"	"39.8"	"36.6"	"42.5"	"57.3"	"63.7"	"57.5"	"149.4"	"146.2"	"93.5"	"101.1"	"149.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96RF0"	"Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2"	"9"	"4"	"5"	"4"	"628"	"68.9"	"5.68"	"577.48"	"9.64"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00787, Pf10456, Pf14604"	"112574"	"ENSG00000178996"	"SNX18"	"B4E2B3; H7BXX3; hsa:112574; Q05BB3; Q0VG02; Q96RF0"	""	"Clathrin-mediated endocytosis"	"1"	"0"	"91.2"	"50.6"	"107.0"	"139.4"	"180.5"	"157.7"	"432.7"	"704.6"	"537.4"	"875.5"	"1184.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UII2"	"ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1"	"14"	"2"	"8"	"2"	"106"	"12.2"	"9.35"	"1304.74"	"9.61"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"mitochondrion;other cell component"	"enzyme regulator activity;other molecular function"	"Pf04568"	"93974"	"ENSG00000130770; ENSG00000285390"	"ATP5IF1"	"hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2"	"Electron transport chain: OXPHOS system in mitochondria"	""	"1"	"0"	"529.5"	"330.3"	"445.9"	"605.6"	"706.8"	"621.1"	"3325.3"	"2894.1"	"2072.3"	"2364.2"	"2820.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WXF0"	"Serine/arginine-rich splicing factor 12 OS=Homo sapiens OX=9606 GN=SRSF12 PE=2 SV=1"	"9"	"3"	"6"	"1"	"261"	"30.5"	"11.69"	"1235.24"	"9.60"	"3"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf00076"	"135295"	"ENSG00000154548"	"SRSF12"	"B2RA22; hsa:135295; Q5T7K0; Q8WW25; Q8WXF0"	""	"mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA"	"2"	"0"	"4.6"	"3.0"	"6.6"	"10.6"	"12.2"	"10.8"	"16.9"	"17.1"	"11.8"	"37.9"	"23.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52907"	"F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3"	"15"	"2"	"3"	"2"	"286"	"32.9"	"5.69"	"449.13"	"9.58"	"1"	"2"	"cell organization and biogenesis"	"non-structural extracellular;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf01267"	"829"	"ENSG00000116489"	"CAPZA1"	"hsa:829; P52907; Q53FQ6; Q6FHD5"	""	"MHC class II antigen presentation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling"	"8"	"0"	"16.5"	"13.7"	"23.2"	"28.9"	"26.7"	"27.2"	"72.4"	"67.7"	"50.9"	"62.3"	"70.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6X4"	"Soluble lamin-associated protein of 75 kDa OS=Homo sapiens OX=9606 GN=FAM169A PE=1 SV=2"	"10"	"4"	"6"	"4"	"670"	"74.9"	"4.60"	"952.39"	"9.57"	"3"	"3"	""	"other membranes;nucleus"	""	""	"26049"	"ENSG00000198780"	"FAM169A"	"A8K1T9; hsa:26049; Q6MZT0; Q9H989; Q9Y6X4"	""	"RHOF GTPase cycle"	"1"	"0"	"69.2"	"42.9"	"70.3"	"107.0"	"123.9"	"119.4"	"172.4"	"177.2"	"130.7"	"138.3"	"252.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61163"	"Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1"	"9"	"3"	"5"	"2"	"376"	"42.6"	"6.64"	"827.26"	"9.53"	"2"	"3"	"transport"	"cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00022"	"10121"	"ENSG00000138107"	"ACTR1A"	"B2R6B0; hsa:10121; P42024; P61163"	""	"MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2"	"11"	"0"	"115.5"	"61.9"	"102.3"	"149.6"	"163.8"	"143.7"	"314.0"	"284.5"	"176.6"	"204.9"	"320.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13148"	"TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1"	"7"	"3"	"6"	"3"	"414"	"44.7"	"6.19"	"1050.62"	"9.52"	"3"	"3"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf18694"	"23435"	"ENSG00000120948"	"TARDBP"	"A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0"	"MECP2 and associated Rett syndrome"	""	"1"	"0"	"277.8"	"132.9"	"232.2"	"360.0"	"482.7"	"395.1"	"735.8"	"595.9"	"228.0"	"440.4"	"595.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14247"	"Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2"	"7"	"4"	"7"	"4"	"550"	"61.5"	"5.40"	"880.33"	"9.51"	"3"	"4"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component"	"other molecular function"	"Pf02218, Pf14604"	"2017"	"ENSG00000085733; ENSG00000288401"	"CTTN"	"hsa:2017; Q14247; Q8N707; Q96H99"	"Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma"	"Clathrin-mediated endocytosis; RHO GTPases activate PAKs"	"4"	"0"	"110.7"	"78.5"	"127.1"	"184.3"	"226.8"	"194.4"	"405.7"	"437.6"	"301.8"	"365.1"	"534.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14635"	"G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1"	"7"	"3"	"6"	"3"	"433"	"48.3"	"7.47"	"1311.23"	"9.47"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00134, Pf02984"	"891"	"ENSG00000134057"	"CCNB1"	"A8K066; hsa:891; P14635; Q5TZP9"	"AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; DNA damage response"	"The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Phosphorylation of Emi1"	"31"	"0"	"57.2"	"33.3"	"46.7"	"59.5"	"89.6"	"69.0"	"576.0"	"544.9"	"309.7"	"388.9"	"446.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16643"	"Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4"	"4"	"2"	"7"	"2"	"649"	"71.4"	"4.45"	"1566.47"	"9.46"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00241"	"1627"	"ENSG00000113758"	"DBN1"	"A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5"	"5q35 copy number variation"	"RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOH GTPase cycle; RHOD GTPase cycle"	"5"	"0"	"270.5"	"129.7"	"217.3"	"326.6"	"439.4"	"332.9"	"746.0"	"608.7"	"279.3"	"604.0"	"940.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9C005"	"Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1"	"31"	"3"	"6"	"3"	"99"	"11.2"	"4.88"	"768.78"	"9.39"	"3"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport"	"ER/Golgi;nucleus"	"other molecular function"	"Pf05186"	"84661"	"ENSG00000162961"	"DPY30"	"D6W578; hsa:84661; Q9C005"	"Kleefstra syndrome"	"Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes"	"5"	"0"	"231.2"	"185.6"	"247.8"	"341.3"	"407.2"	"379.2"	"794.1"	"744.4"	"452.3"	"580.4"	"654.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61353"	"60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2"	"25"	"5"	"8"	"5"	"136"	"15.8"	"10.56"	"1288.14"	"9.39"	"4"	"4"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf00467, Pf01777"	"6155"	"ENSG00000131469"	"RPL27"	"hsa:6155; P08526; P61353; Q4G0A9"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"260.7"	"174.9"	"219.0"	"266.0"	"369.2"	"307.4"	"1627.8"	"1382.6"	"928.6"	"1128.4"	"1240.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BVJ6"	"U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1"	"5"	"3"	"5"	"3"	"771"	"87.9"	"7.87"	"790.46"	"9.34"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	""	"Pf04615"	"10813"	"ENSG00000156697"	"UTP14A"	"A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"17.5"	"12.4"	"23.8"	"22.4"	"35.9"	"30.8"	"83.8"	"92.8"	"53.6"	"66.5"	"93.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50914"	"60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4"	"19"	"4"	"7"	"4"	"215"	"23.4"	"10.93"	"1322.72"	"9.34"	"4"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf01929"	"9045"	"ENSG00000188846"	"RPL14"	"hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"206.3"	"135.4"	"198.2"	"276.4"	"332.1"	"249.0"	"1264.6"	"1096.7"	"740.0"	"899.5"	"942.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75694"	"Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1"	"2"	"4"	"7"	"4"	"1391"	"155.1"	"6.16"	"773.54"	"9.32"	"3"	"4"	"cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"other membranes;cytosol;nucleus"	"other molecular function"	"Pf03177, Pf08801"	"9631"	"ENSG00000113569"	"NUP155"	"hsa:9631; O75694; Q9UBE9; Q9UFL5"	""	"HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation"	"29"	"0"	"210.5"	"161.9"	"231.0"	"367.7"	"426.0"	"343.1"	"707.8"	"656.9"	"383.3"	"442.0"	"621.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15511"	"Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3"	"21"	"3"	"7"	"3"	"151"	"16.3"	"5.67"	"1454.79"	"9.31"	"3"	"2"	"cell organization and biogenesis;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity"	"Pf04699"	"10092"	"ENSG00000162704"	"ARPC5"	"A6NEC4; hsa:10092; O15511; Q6PG42"	"Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling"	"8"	"0"	"105.1"	"91.6"	"113.7"	"143.4"	"171.1"	"164.5"	"385.2"	"493.1"	"387.0"	"583.6"	"1442.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96N67"	"Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4"	"2"	"3"	"5"	"3"	"2140"	"242.4"	"6.80"	"822.97"	"9.28"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"other cell component"	"enzyme regulator activity;other molecular function"	"Pf06920, Pf11878, Pf14429, Pf20421, Pf20422"	"85440"	"ENSG00000116641"	"DOCK7"	"hsa:85440; Q00M63; Q2PPY7; Q45RE8; Q45RE9; Q5T1B9; Q5T1C0; Q6ZV32; Q8TB82; Q96N67; Q96NG6; Q96NI0; Q9C092"	""	"CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1"	"4"	"0"	"48.0"	"33.3"	"52.9"	"68.6"	"85.8"	"76.3"	"215.4"	"219.4"	"106.0"	"138.0"	"198.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9GZT3"	"SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1"	"39"	"4"	"7"	"4"	"109"	"12.3"	"10.24"	"1244.72"	"9.28"	"4"	"3"	"cell organization and biogenesis;other biological processes"	"cytoskeleton;mitochondrion;nucleus;other cell component"	""	"Pf00076"	"81892"	"ENSG00000119705"	"SLIRP"	"hsa:81892; J3KMY7; Q9GZT3"	""	""	"0"	"0"	"172.9"	"114.5"	"178.9"	"276.1"	"321.1"	"280.0"	"693.2"	"732.7"	"390.3"	"491.2"	"583.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60228"	"Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1"	"11"	"5"	"6"	"5"	"445"	"52.2"	"6.04"	"1153.37"	"9.26"	"3"	"3"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity"	"Pf01399, Pf09440"	"3646"	"ENSG00000104408"	"EIF3E"	"hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit"	"8"	"0"	"241.3"	"151.2"	"220.1"	"309.1"	"391.1"	"344.2"	"793.4"	"767.6"	"468.6"	"558.8"	"889.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q05519"	"Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1"	"8"	"3"	"5"	"3"	"484"	"53.5"	"10.52"	"811.23"	"9.26"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00076"	"9295"	"ENSG00000116754"	"SRSF11"	"hsa:9295; Q05519; Q5T758; Q8IWE6"	""	"mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"5"	"0"	"214.2"	"115.1"	"169.6"	"252.2"	"272.1"	"246.0"	"555.4"	"495.5"	"241.2"	"366.1"	"544.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05386"	"60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1"	"34"	"3"	"7"	"2"	"114"	"11.5"	"4.32"	"1277.23"	"9.24"	"3"	"2"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00428"	"6176"	"ENSG00000137818"	"RPLP1"	"A6NIB2; hsa:6176; P05386"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"277.7"	"147.4"	"227.8"	"275.1"	"338.8"	"276.5"	"1404.2"	"1229.8"	"778.9"	"1043.0"	"1356.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NWH9"	"SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2"	"3"	"3"	"7"	"3"	"1034"	"117.1"	"7.87"	"1057.04"	"9.23"	"3"	"3"	"other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076, Pf02037"	"79811"	"ENSG00000137776"	"SLTM"	"A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9"	""	""	"0"	"0"	"100.8"	"56.1"	"69.5"	"102.5"	"139.6"	"119.9"	"387.2"	"358.6"	"218.0"	"331.9"	"379.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y520"	"Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4"	"1"	"4"	"7"	"4"	"2896"	"316.7"	"9.13"	"1337.37"	"9.21"	"4"	"3"	"cell organization and biogenesis;other biological processes"	"cytosol;other cell component"	""	"Pf07001"	"23215"	"ENSG00000117523"	"PRRC2C"	"hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"26.4"	"10.3"	"26.3"	"38.6"	"35.7"	"37.8"	"173.4"	"172.5"	"163.0"	"193.9"	"197.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01780"	"Exosome component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2"	"5"	"4"	"7"	"4"	"885"	"100.8"	"8.46"	"1183.20"	"9.17"	"4"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00570, Pf01612, Pf08066"	"5394"	"ENSG00000171824"	"EXOSC10"	"B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"60.9"	"44.0"	"54.2"	"81.3"	"97.9"	"80.1"	"231.5"	"277.8"	"210.4"	"274.1"	"359.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25787"	"Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2"	"14"	"3"	"6"	"3"	"234"	"25.9"	"7.43"	"936.23"	"9.16"	"3"	"3"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	""	"Pf00227, Pf10584"	"5683"	"ENSG00000106588"	"PSMA2"	"hsa:5683; P25787; Q6ICS6; Q9BU45"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"ER-Phagosome pathway; Neutrophil degranulation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"63"	"0"	"155.7"	"98.1"	"140.5"	"180.7"	"230.1"	"202.8"	"631.1"	"611.6"	"435.9"	"512.0"	"666.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q05048"	"Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1"	"7"	"3"	"6"	"3"	"431"	"48.3"	"6.58"	"1022.77"	"9.15"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf00400, Pf16699"	"1477"	"ENSG00000101138"	"CSTF1"	"hsa:1477; Q05048; Q5QPD8"	"mRNA processing"	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs"	"5"	"0"	"303.2"	"206.1"	"284.9"	"458.9"	"539.6"	"446.1"	"1188.9"	"1165.4"	"687.4"	"850.0"	"1134.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P24752"	"Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1"	"8"	"3"	"7"	"3"	"427"	"45.2"	"8.85"	"1359.52"	"9.13"	"3"	"2"	"other metabolic processes;stress response;developmental processes;other biological processes"	"mitochondrion;ER/Golgi"	"other molecular function"	"Pf00108, Pf02803"	"38"	"ENSG00000075239"	"ACAT1"	"B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8"	"Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway"	"Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies"	"6"	"0"	"109.1"	"60.0"	"105.7"	"142.9"	"175.3"	"163.8"	"351.2"	"340.9"	"263.3"	"320.4"	"477.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92890"	"Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3"	"12"	"3"	"6"	"3"	"307"	"34.5"	"6.70"	"1081.06"	"9.12"	"3"	"3"	"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf03152"	"7353"	"ENSG00000070010"	"UFD1"	"A8MW31; hsa:7353; Q92890; Q9Y5N0"	"22q11.2 copy number variation syndrome"	"Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH"	"5"	"0"	"62.9"	"63.8"	"73.5"	"105.2"	"124.8"	"107.9"	"243.8"	"226.2"	"190.6"	"225.5"	"234.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2S7"	"Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1"	"10"	"3"	"5"	"3"	"368"	"42.0"	"8.63"	"748.43"	"9.11"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity"	"Pf04379, Pf08755"	"26073"	"ENSG00000004142"	"POLDIP2"	"B2R846; hsa:26073; Q96JE4; Q9Y2S7"	""	""	"0"	"0"	"70.4"	"50.3"	"76.8"	"126.9"	"135.9"	"126.6"	"229.2"	"222.5"	"168.2"	"210.1"	"234.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P21796"	"Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2"	"13"	"4"	"6"	"3"	"283"	"30.8"	"8.54"	"485.75"	"9.09"	"2"	"4"	"cell-cell signaling;other metabolic processes;stress response;transport;other biological processes"	"plasma membrane;other membranes;mitochondrion;other cell component"	"transporter activity;other molecular function"	"Pf01459"	"7416"	"ENSG00000213585"	"VDAC1"	"B3KVK4; D3DQ93; hsa:7416; P21796; Q5FVE7; Q9UIQ5; Q9UPL0"	"Alzheimer's disease and miRNA effects; Alzheimer's disease; Arsenic metabolism and reactive oxygen species generation; Cholesterol metabolism; Fatty Acids and Lipoproteins Transport in Hepatocytes"	"Ub-specific processing proteases; Pyruvate metabolism; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy; Mitochondrial calcium ion transport"	"10"	"0"	"212.8"	"125.3"	"165.0"	"203.4"	"331.0"	"271.3"	"494.6"	"463.8"	"199.8"	"381.9"	"499.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BZZ5"	"Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3"	"6"	"3"	"6"	"3"	"524"	"59.0"	"7.34"	"948.09"	"9.06"	"3"	"3"	"other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf05918"	"8539"	"ENSG00000166181"	"API5"	"B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7"	""	""	"0"	"0"	"20.1"	"12.0"	"26.4"	"24.9"	"41.2"	"35.2"	"113.8"	"102.4"	"46.4"	"86.2"	"106.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P98179"	"RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1"	"24"	"3"	"6"	"3"	"157"	"17.2"	"8.91"	"1213.32"	"9.06"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"translation activity"	"Pf00076"	"5935"	"ENSG00000102317"	"RBM3"	"hsa:5935; P98179"	""	""	"0"	"0"	"321.0"	"337.9"	"336.1"	"334.1"	"376.5"	"368.9"	"881.8"	"734.5"	"978.2"	"912.3"	"819.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75534"	"Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2"	"4"	"3"	"6"	"3"	"798"	"88.8"	"6.25"	"939.14"	"9.06"	"3"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"nucleic acid binding activity"	"Pf00313, Pf12901"	"7812"	"ENSG00000009307"	"CSDE1"	"A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4"	""	""	"0"	"0"	"89.8"	"59.3"	"88.1"	"128.3"	"164.7"	"153.7"	"297.1"	"277.9"	"157.6"	"281.4"	"454.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96FV9"	"THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1"	"5"	"3"	"5"	"3"	"657"	"75.6"	"4.98"	"696.32"	"9.06"	"2"	"3"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00531, Pf11957"	"9984"	"ENSG00000079134"	"THOC1"	"B2RBP6; hsa:9984; Q15219; Q64I72; Q64I73; Q96FV9"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"3"	"0"	"92.6"	"66.7"	"89.9"	"120.6"	"158.5"	"138.6"	"344.7"	"312.4"	"207.6"	"306.4"	"330.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14168"	"MAGUK p55 subfamily member 2 OS=Homo sapiens OX=9606 GN=MPP2 PE=1 SV=3"	"7"	"3"	"6"	"2"	"576"	"64.5"	"6.77"	"1038.35"	"9.06"	"3"	"3"	"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cell component"	""	"Pf00595, Pf00625, Pf02828, Pf07653"	"4355"	"ENSG00000108852"	"MPP2"	"B4DGE9; B4DRJ0; B7Z3G8; E7EV80; E7EV91; E7EX01; hsa:4355; Q14168; Q53ES9; Q5CZB9; Q9BQJ2"	""	""	"0"	"0"	"11.7"	"5.8"	"8.9"	"8.7"	"8.8"	"13.5"	"18.5"	"24.4"	"26.6"	"28.4"	"24.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q68CQ4"	"Digestive organ expansion factor homolog OS=Homo sapiens OX=9606 GN=DIEXF PE=1 SV=2"	"6"	"4"	"7"	"4"	"756"	"87.0"	"5.88"	"1355.11"	"9.03"	"4"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf06862"	"27042"	"ENSG00000117597"	"UTP25"	"hsa:27042; O75992; Q4VY00; Q63HL9; Q68CQ4"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"26.7"	"17.7"	"22.2"	"40.4"	"42.0"	"41.1"	"134.4"	"111.8"	"62.2"	"73.8"	"100.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5D862"	"Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1"	"1"	"2"	"6"	"2"	"2391"	"247.9"	"8.31"	"881.55"	"9.02"	"2"	"2"	"cell adhesion;other biological processes"	"non-structural extracellular;plasma membrane;other cell component"	"other molecular function"	"Pf01023"	"388698"	"ENSG00000143520"	"FLG2"	"hsa:388698; Q5D862; Q9H4U1"	""	"Neutrophil degranulation"	"1"	"0"	"19.1"	"12.5"	"16.7"	"13.9"	"27.4"	"41.2"	"41.4"	"531.1"	"28.1"	"19.0"	"44.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H2U1"	"ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2"	"4"	"3"	"6"	"3"	"1008"	"114.7"	"7.68"	"1009.72"	"8.93"	"3"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf04408, Pf07717"	"170506"	"ENSG00000174953"	"DHX36"	"B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240"	"VEGFA-VEGFR2 signaling"	"DEx/H-box helicases activate type I IFN and inflammatory cytokines production"	"2"	"0"	"52.9"	"34.7"	"58.6"	"70.3"	"81.0"	"64.8"	"174.8"	"198.8"	"121.6"	"155.2"	"204.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49790"	"Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2"	"3"	"4"	"5"	"4"	"1475"	"153.8"	"8.73"	"673.31"	"8.91"	"2"	"3"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00641, Pf08604, Pf10599"	"9972"	"ENSG00000124789"	"NUP153"	"B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743"	""	"Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"28"	"0"	"84.8"	"55.8"	"75.5"	"110.4"	"117.9"	"105.4"	"235.4"	"234.5"	"127.7"	"197.6"	"217.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61313"	"60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2"	"14"	"3"	"6"	"3"	"204"	"24.1"	"11.62"	"1048.40"	"8.88"	"3"	"3"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf00827"	"6138"	"ENSG00000174748"	"RPL15"	"hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"215.2"	"169.5"	"202.5"	"227.4"	"284.2"	"232.3"	"999.5"	"877.0"	"660.7"	"864.7"	"849.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20248"	"Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2"	"6"	"2"	"4"	"2"	"432"	"48.5"	"6.54"	"1023.56"	"8.86"	"2"	"2"	"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00134, Pf02984, Pf16500"	"890"	"ENSG00000145386"	"CCNA2"	"A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8"	"AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; IL-18 signaling pathway"	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes"	"24"	"0"	"47.5"	"29.4"	"41.2"	"61.6"	"65.4"	"52.3"	"194.3"	"211.1"	"162.3"	"166.5"	"299.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15075"	"Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2"	"4"	"4"	"7"	"4"	"1411"	"162.4"	"5.68"	"1493.24"	"8.86"	"4"	"3"	"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf01363"	"8411"	"ENSG00000102189"	"EEA1"	"hsa:8411; Q14221; Q15075"	"VEGFA-VEGFR2 signaling"	"Toll Like Receptor 9 (TLR9) Cascade"	"2"	"0"	"20.1"	"13.3"	"18.9"	"29.9"	"33.2"	"29.0"	"115.3"	"110.4"	"76.0"	"98.3"	"180.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13363"	"C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2"	"8"	"4"	"7"	"2"	"440"	"47.5"	"6.77"	"1371.41"	"8.83"	"4"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00389, Pf02826"	"1487"	"ENSG00000159692"	"CTBP1"	"hsa:1487; Q13363; Q4W5N3; Q7Z2Q5"	"Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma"	"SUMOylation of transcription cofactors; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes; Signaling by TCF7L2 mutants"	"14"	"2"	"281.6"	"222.3"	"343.8"	"534.6"	"586.2"	"477.6"	"905.0"	"1092.6"	"464.7"	"510.1"	"498.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H5V9"	"UPF0428 protein CXorf56 OS=Homo sapiens OX=9606 GN=CXorf56 PE=1 SV=1"	"14"	"3"	"5"	"3"	"222"	"25.6"	"8.73"	"725.19"	"8.83"	"2"	"3"	"cell organization and biogenesis;transport"	"cytoskeleton;nucleus;other cell component"	""	""	"63932"	"ENSG00000018610"	"STEEP1"	"A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"72.3"	"38.0"	"56.3"	"95.6"	"106.6"	"97.1"	"391.8"	"421.7"	"241.0"	"313.5"	"424.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y376"	"Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1"	"10"	"3"	"6"	"3"	"341"	"39.8"	"6.89"	"959.18"	"8.79"	"3"	"3"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component"	"enzyme regulator activity;other molecular function"	"Pf08569"	"51719"	"ENSG00000135932"	"CAB39"	"A8K8L7; hsa:51719; Q9Y376"	"AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias"	"Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK"	"6"	"0"	"12.7"	"9.4"	"15.6"	"16.7"	"23.8"	"20.8"	"51.7"	"56.3"	"42.7"	"72.6"	"67.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43768"	"Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1"	"40"	"4"	"7"	"4"	"121"	"13.4"	"7.24"	"1338.08"	"8.77"	"4"	"3"	"cell cycle OR cell proliferation;other biological processes"	"nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf04667"	"2029"	"ENSG00000143420"	"ENSA"	"A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0"	""	"MASTL Facilitates Mitotic Progression"	"1"	"0"	"252.4"	"152.4"	"235.0"	"257.4"	"340.1"	"352.8"	"653.6"	"642.8"	"429.0"	"528.0"	"966.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6P6C2"	"RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2"	"5"	"2"	"4"	"2"	"394"	"44.2"	"9.09"	"1077.16"	"8.76"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes"	"cytosol;ER/Golgi;nucleus"	"other molecular function"	"Pf13532"	"54890"	"ENSG00000091542"	"ALKBH5"	"B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6"	"Smith-Magenis and Potocki-Lupski syndrome copy number variation"	"Reversal of alkylation damage by DNA dioxygenases"	"2"	"0"	"4.4"	"4.8"	"6.9"	"7.1"	"8.1"	"6.6"	"52.0"	"47.3"	"33.8"	"34.9"	"31.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P83876"	"Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1"	"22"	"3"	"6"	"3"	"142"	"16.8"	"5.85"	"1050.59"	"8.75"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other membranes;cytosol;nucleus"	""	"Pf02966"	"10907"	"ENSG00000141759"	"TXNL4A"	"B2RC18; hsa:10907; O14834; P83876"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway"	"3"	"0"	"39.4"	"26.1"	"39.6"	"49.4"	"69.6"	"61.2"	"136.4"	"133.0"	"82.5"	"143.2"	"189.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P41252"	"Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2"	"4"	"4"	"6"	"4"	"1262"	"144.4"	"6.15"	"1038.77"	"8.74"	"3"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00133, Pf08264, Pf19302"	"3376"	"ENSG00000196305"	"IARS1"	"A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588"	"Amino acid metabolism"	"Selenoamino acid metabolism; Cytosolic tRNA aminoacylation"	"3"	"0"	"88.7"	"62.8"	"86.4"	"119.7"	"153.6"	"133.1"	"235.4"	"238.3"	"163.4"	"212.4"	"247.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61218"	"DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Homo sapiens OX=9606 GN=POLR2F PE=1 SV=1"	"33"	"4"	"6"	"4"	"127"	"14.5"	"4.22"	"940.19"	"8.70"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01192"	"5435"	"ENSG00000100142"	"POLR2F"	"hsa:5435; P41584; P61218; Q6IAY3"	"Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome"	"mRNA Splicing - Major Pathway; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"56"	"0"	"230.8"	"186.5"	"236.3"	"321.3"	"409.8"	"392.4"	"837.7"	"955.5"	"838.2"	"999.4"	"1604.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51970"	"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Homo sapiens OX=9606 GN=NDUFA8 PE=1 SV=3"	"19"	"4"	"8"	"4"	"172"	"20.1"	"7.65"	"1442.36"	"8.69"	"4"	"3"	"cell organization and biogenesis;other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf06747"	"4702"	"ENSG00000119421"	"NDUFA8"	"B1AM93; hsa:4702; P51970; Q9Y6N0"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"5"	"0"	"289.7"	"198.8"	"306.7"	"518.7"	"634.0"	"490.8"	"1763.1"	"1600.8"	"1175.6"	"1383.7"	"1671.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NS86"	"LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1"	"8"	"3"	"5"	"3"	"450"	"50.8"	"7.43"	"715.29"	"8.64"	"2"	"3"	"other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus"	"other molecular function"	"Pf05147"	"55915"	"ENSG00000132434"	"LANCL2"	"B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86"	""	""	"0"	"0"	"55.0"	"48.0"	"65.3"	"83.4"	"95.9"	"84.9"	"201.6"	"220.8"	"169.6"	"200.4"	"263.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07196"	"Neurofilament light polypeptide OS=Homo sapiens OX=9606 GN=NEFL PE=1 SV=3"	"5"	"3"	"6"	"2"	"543"	"61.5"	"4.65"	"908.48"	"8.63"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes"	"cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00038, Pf04732"	"4747"	"ENSG00000277586"	"NEFL"	"B9ZVN2; hsa:4747; P07196; Q16154; Q8IU72"	"Amyotrophic lateral sclerosis (ALS); Physico-chemical features and toxicity-associated pathways; NO/cGMP/PKG mediated neuroprotection; Ciliary landscape; Intracellular trafficking proteins involved in CMT neuropathy; CCL18 signaling pathway"	"Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation"	"12"	"0"	"96.7"	"80.7"	"116.6"	"138.7"	"195.2"	"160.0"	"230.5"	"211.3"	"132.3"	"196.2"	"231.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2D5"	"A-kinase anchor protein 2 OS=Homo sapiens OX=9606 GN=AKAP2 PE=1 SV=3"	"3"	"2"	"6"	"2"	"859"	"94.6"	"5.11"	"1243.02"	"8.61"	"2"	"2"	""	""	""	"Pf15304"	"445815"	""	"AKAP2"	"B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; Q9UG26; Q9Y2D5"	""	""	"0"	"0"	"15.4"	"14.1"	"19.4"	"33.0"	"28.9"	"21.8"	"94.5"	"80.8"	"59.9"	"65.5"	"81.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O76021"	"Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3"	"10"	"4"	"7"	"4"	"490"	"54.9"	"10.13"	"1234.13"	"8.61"	"4"	"3"	"other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00687"	"26156"	"ENSG00000171490"	"RSL1D1"	"B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9"	""	""	"0"	"0"	"35.8"	"24.7"	"32.4"	"35.0"	"62.8"	"57.5"	"140.5"	"124.2"	"75.4"	"115.1"	"140.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P47755"	"F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3"	"19"	"3"	"6"	"3"	"286"	"32.9"	"5.85"	"966.87"	"8.59"	"3"	"3"	"cell organization and biogenesis"	"non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf01267"	"830"	"ENSG00000198898"	"CAPZA2"	"B4DG50; hsa:830; P47755"	""	"MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling"	"7"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31483"	"Nucleolysin TIA-1 isoform p40 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3"	"11"	"4"	"7"	"2"	"386"	"42.9"	"7.74"	"1461.23"	"8.58"	"4"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"7072"	"ENSG00000116001"	"TIA1"	"hsa:7072; P31483; Q53SS9; Q96B58"	""	"FGFR2 alternative splicing"	"1"	"0"	"44.2"	"38.2"	"41.9"	"80.3"	"96.2"	"66.5"	"213.0"	"184.4"	"145.1"	"133.6"	"101.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O96019"	"Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1"	"9"	"3"	"5"	"3"	"429"	"47.4"	"5.60"	"586.33"	"8.57"	"2"	"3"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	"other molecular function"	"Pf00022"	"86"	"ENSG00000136518"	"ACTL6A"	"B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6"	"Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome"	"UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; HATs acetylate histones; DNA Damage Recognition in GG-NER"	"10"	"0"	"68.5"	"43.6"	"75.3"	"80.5"	"101.1"	"97.7"	"201.5"	"180.8"	"119.1"	"153.3"	"230.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P29590"	"Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3"	"4"	"2"	"3"	"2"	"882"	"97.5"	"6.21"	"598.88"	"8.55"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00643, Pf12126"	"5371"	"ENSG00000140464"	"PML"	"E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3"	"miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; p53 transcriptional gene network; DNA damage response"	"Interferon gamma signaling; Regulation of PTEN localization; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of TP53 Activity through Acetylation; Regulation of RUNX1 Expression and Activity"	"11"	"0"	"60.2"	"58.9"	"82.2"	"143.9"	"149.3"	"126.3"	"257.4"	"237.1"	"131.7"	"183.6"	"231.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30086"	"Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3"	"15"	"2"	"4"	"2"	"187"	"21.0"	"7.53"	"854.31"	"8.55"	"2"	"2"	"other biological processes"	"cytosol"	"enzyme regulator activity;other molecular function"	"Pf01161"	"5037"	"ENSG00000089220"	"PEBP1"	"B2R4S1; hsa:5037; P30086"	"Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway"	"Negative regulation of MAPK pathway; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants"	"9"	"0"	"46.0"	"40.0"	"51.1"	"71.1"	"91.6"	"81.8"	"174.9"	"164.8"	"106.0"	"162.6"	"254.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13889"	"General transcription factor IIH subunit 3 OS=Homo sapiens OX=9606 GN=GTF2H3 PE=1 SV=2"	"13"	"2"	"3"	"2"	"308"	"34.4"	"7.02"	"390.75"	"8.54"	"1"	"2"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf03850"	"2967"	"ENSG00000111358"	"GTF2H3"	"B2R819; B4DNZ6; hsa:2967; Q13889; Q7L0G0; Q96AT7"	"Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination"	"33"	"0"	"5.4"	"2.6"	"3.6"	"9.0"	"6.9"	"5.3"	"33.0"	"78.6"	"88.1"	"91.8"	"92.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99569"	"Plakophilin-4 OS=Homo sapiens OX=9606 GN=PKP4 PE=1 SV=2"	"4"	"3"	"6"	"3"	"1192"	"131.8"	"8.94"	"975.03"	"8.54"	"3"	"3"	"cell adhesion;cell-cell signaling;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00514"	"8502"	"ENSG00000144283"	"PKP4"	"hsa:8502; Q86W91; Q99569"	""	"Formation of the cornified envelope; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle"	"5"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92820"	"Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2"	"17"	"5"	"8"	"5"	"318"	"35.9"	"7.11"	"1703.29"	"8.54"	"5"	"3"	"other metabolic processes"	"non-structural extracellular;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf07722"	"8836"	"ENSG00000137563"	"GGH"	"hsa:8836; Q92820"	"Fluoropyrimidine activity"	"Neutrophil degranulation"	"2"	"0"	"81.9"	"60.8"	"91.6"	"109.4"	"124.3"	"147.8"	"387.5"	"706.1"	"602.5"	"957.5"	"1736.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43583"	"Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2"	"20"	"2"	"3"	"2"	"198"	"22.1"	"5.30"	"481.97"	"8.53"	"1"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	""	"nucleic acid binding activity"	"Pf01253"	"8562"	"ENSG00000139726"	"DENR"	"hsa:8562; O43583; Q9H3U6; Q9UKZ0"	""	""	"0"	"0"	"11.3"	"6.7"	"8.9"	"13.1"	"20.4"	"15.7"	"134.2"	"115.3"	"71.0"	"108.9"	"196.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15144"	"Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1"	"8"	"3"	"5"	"3"	"300"	"34.3"	"7.36"	"607.76"	"8.47"	"2"	"3"	"cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity"	"Pf04045"	"10109"	"ENSG00000163466"	"ARPC2"	"hsa:10109; O15144; Q92801; Q9P1D4"	"Pathogenic Escherichia coli infection"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling"	"6"	"0"	"113.9"	"83.2"	"123.3"	"152.7"	"217.2"	"180.7"	"453.9"	"617.1"	"438.5"	"690.8"	"1755.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UEY8"	"Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1"	"4"	"2"	"4"	"2"	"706"	"79.1"	"6.32"	"841.37"	"8.46"	"2"	"2"	"cell organization and biogenesis"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00596"	"120"	"ENSG00000148700"	"ADD3"	"D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8"	""	"Miscellaneous transport and binding events; RHOD GTPase cycle; RHOF GTPase cycle"	"3"	"0"	"42.0"	"29.7"	"44.6"	"60.9"	"79.6"	"66.6"	"173.7"	"173.2"	"111.2"	"157.9"	"184.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61160"	"Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1"	"10"	"3"	"4"	"2"	"394"	"44.7"	"6.74"	"333.97"	"8.44"	"1"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00022"	"10097"	"ENSG00000138071"	"ACTR2"	"B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82"	"Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling"	"8"	"0"	"10.7"	"6.9"	"12.0"	"18.3"	"17.5"	"24.0"	"50.6"	"71.9"	"41.0"	"61.2"	"129.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20674"	"Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2"	"25"	"3"	"6"	"3"	"150"	"16.8"	"6.79"	"1007.87"	"8.44"	"3"	"3"	"other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf02284"	"9377"	"ENSG00000178741"	"COX5A"	"hsa:9377; P20674; P30045; Q8TB65"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase"	"Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1"	"8"	"0"	"173.7"	"138.3"	"132.0"	"178.7"	"234.0"	"207.4"	"333.3"	"285.6"	"145.2"	"318.7"	"328.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28331"	"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3"	"4"	"3"	"6"	"3"	"727"	"79.4"	"6.23"	"873.32"	"8.43"	"3"	"3"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf00384, Pf09326, Pf10588, Pf13510"	"4719"	"ENSG00000023228; ENSG00000283447"	"NDUFS1"	"B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"5"	"0"	"129.2"	"89.6"	"95.2"	"122.7"	"167.9"	"124.0"	"247.2"	"229.4"	"131.7"	"200.4"	"262.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14654"	"Insulin receptor substrate 4 OS=Homo sapiens OX=9606 GN=IRS4 PE=1 SV=1"	"3"	"4"	"7"	"4"	"1257"	"133.7"	"8.44"	"1160.92"	"8.43"	"4"	"3"	"signal transduction"	"plasma membrane;other membranes;cytosol"	"signal transduction activity or receptor binding;other molecular function"	"Pf02174"	"8471"	"ENSG00000133124"	"IRS4"	"hsa:8471; O14654"	"Alzheimer's disease and miRNA effects; Adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; Insulin signaling; Alzheimer's disease"	"IRS-related events triggered by IGF1R"	"8"	"0"	"145.1"	"106.5"	"145.7"	"179.6"	"227.7"	"184.9"	"471.3"	"466.5"	"339.9"	"443.4"	"503.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61956"	"Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3"	"23"	"2"	"5"	"2"	"95"	"10.9"	"5.50"	"651.69"	"8.42"	"2"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf11976"	"6613"	"ENSG00000188612"	"SUMO2"	"B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1"	"TAR syndrome"	"SUMOylation of transcription cofactors; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed"	"15"	"0"	"100.6"	"69.3"	"103.1"	"132.0"	"161.6"	"170.8"	"330.5"	"329.7"	"212.9"	"281.1"	"492.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVA2"	"Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3"	"8"	"3"	"6"	"2"	"429"	"49.4"	"6.81"	"1025.40"	"8.41"	"3"	"3"	"cell cycle OR cell proliferation"	"cytoskeleton;other cell component"	"other molecular function"	"Pf00735"	"55752"	"ENSG00000138758"	"SEPTIN11"	"B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9"	"22q11.2 copy number variation syndrome"	""	"1"	"0"	"16.9"	"12.7"	"22.5"	"25.0"	"33.8"	"36.5"	"137.8"	"139.7"	"117.7"	"144.1"	"180.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15020"	"Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1"	"4"	"3"	"5"	"3"	"963"	"109.9"	"5.57"	"651.20"	"8.40"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00076, Pf05391, Pf16605"	"9733"	"ENSG00000075856"	"SART3"	"A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95"	""	""	"0"	"0"	"53.3"	"25.8"	"42.8"	"64.8"	"86.3"	"73.6"	"224.7"	"203.8"	"103.9"	"144.8"	"177.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61970"	"Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1"	"24"	"3"	"7"	"3"	"127"	"14.5"	"5.38"	"1262.56"	"8.34"	"3"	"2"	"transport;other biological processes"	"other membranes;cytosol;nucleus"	"other molecular function"	"Pf02136"	"10204"	"ENSG00000102898"	"NUTF2"	"B2R4G7; hsa:10204; P13662; P61970; Q6IB67"	""	""	"0"	"0"	"198.7"	"172.0"	"221.7"	"253.9"	"329.7"	"360.4"	"494.2"	"460.8"	"328.6"	"480.8"	"918.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43813"	"Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1"	"8"	"3"	"6"	"3"	"399"	"45.3"	"7.75"	"953.73"	"8.33"	"3"	"3"	"other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf05147"	"10314"	"ENSG00000115365"	"LANCL1"	"hsa:10314; O43813"	""	""	"0"	"0"	"104.5"	"76.4"	"105.0"	"165.3"	"204.1"	"171.1"	"562.2"	"556.1"	"398.0"	"456.1"	"563.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43670"	"BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1"	"4"	"2"	"6"	"2"	"478"	"50.7"	"9.10"	"1013.20"	"8.33"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	""	"7756"	"ENSG00000010244"	"ZNF207"	"A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7"	""	""	"0"	"0"	"91.8"	"34.8"	"76.1"	"104.6"	"127.6"	"106.7"	"1143.3"	"1067.5"	"374.3"	"627.6"	"1070.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NUJ1"	"Mycophenolic acid acyl-glucuronide esterase, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1"	"9"	"2"	"6"	"2"	"306"	"33.9"	"8.57"	"1272.64"	"8.32"	"2"	"2"	"protein metabolism;other metabolic processes"	"cytosol;mitochondrion"	"other molecular function"	"Pf00561"	"55347"	"ENSG00000144827"	"ABHD10"	"B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1"	""	"Glucuronidation"	"1"	"0"	"33.0"	"27.9"	"37.1"	"54.9"	"65.6"	"66.5"	"116.4"	"125.7"	"89.5"	"108.6"	"177.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18077"	"60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2"	"37"	"6"	"9"	"6"	"110"	"12.5"	"11.06"	"1817.41"	"8.31"	"6"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01247"	"6165"	"ENSG00000182899"	"RPL35A"	"hsa:6165; P18077; Q08ES9; Q9BVN7"	"Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"396.8"	"217.5"	"345.7"	"402.8"	"593.8"	"467.2"	"2263.6"	"2056.9"	"1176.7"	"1548.4"	"2099.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75874"	"Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2"	"7"	"3"	"6"	"3"	"414"	"46.6"	"7.01"	"886.74"	"8.31"	"3"	"3"	"other metabolic processes;stress response;developmental processes;other biological processes"	"non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00180"	"3417"	"ENSG00000138413"	"IDH1"	"hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8"	"Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism"	"Neutrophil degranulation; Peroxisomal protein import; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes"	"8"	"0"	"136.9"	"101.4"	"163.0"	"216.2"	"235.2"	"241.7"	"390.7"	"422.4"	"278.7"	"343.1"	"499.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19447"	"General transcription and DNA repair factor IIH helicase subunit XPB OS=Homo sapiens OX=9606 GN=ERCC3 PE=1 SV=1"	"3"	"2"	"6"	"2"	"782"	"89.2"	"7.23"	"1013.26"	"8.29"	"2"	"2"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04851, Pf13625, Pf16203"	"2071"	"ENSG00000163161"	"ERCC3"	"hsa:2071; P19447; Q53QM0"	"Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER"	"33"	"0"	"30.8"	"21.9"	"28.7"	"37.3"	"57.7"	"43.2"	"127.1"	"227.8"	"225.0"	"300.0"	"392.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14737"	"Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3"	"29"	"4"	"6"	"4"	"125"	"14.3"	"6.04"	"850.81"	"8.20"	"3"	"3"	"other biological processes"	"cytosol;nucleus"	"enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf01984"	"9141"	"ENSG00000105185"	"PDCD5"	"B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70"	""	""	"0"	"0"	"403.1"	"252.2"	"392.3"	"460.3"	"558.4"	"630.5"	"909.4"	"915.1"	"694.6"	"847.4"	"1374.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P84098"	"60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1"	"16"	"3"	"5"	"2"	"196"	"23.5"	"11.47"	"1103.19"	"8.18"	"3"	"2"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf01280"	"6143"	"ENSG00000108298"	"RPL19"	"B2R4K2; hsa:6143; P14118; P22908; P84098; Q502Y6; Q7Z6E4"	"Cytoplasmic ribosomal proteins"	"Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"1"	"270.4"	"168.9"	"241.1"	"258.1"	"365.4"	"290.4"	"1376.7"	"1211.8"	"805.5"	"928.3"	"1044.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UNX4"	"WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1"	"3"	"3"	"5"	"3"	"943"	"106.0"	"6.64"	"681.24"	"8.15"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other membranes;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00400, Pf04003, Pf12894"	"10885"	"ENSG00000065183"	"WDR3"	"hsa:10885; Q9UNX4"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"55.8"	"30.5"	"48.1"	"50.5"	"75.3"	"67.9"	"176.4"	"191.8"	"179.2"	"265.0"	"358.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NP97"	"Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3"	"35"	"3"	"5"	"3"	"96"	"10.9"	"7.25"	"660.94"	"8.15"	"2"	"2"	"other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf03259"	"83658"	"ENSG00000125971"	"DYNLRB1"	"B1AKR5; hsa:83658; Q5TC72; Q96IV3; Q9NP97; Q9NQM2"	"Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome"	"Intraflagellar transport"	"4"	"0"	"106.5"	"81.5"	"109.4"	"145.4"	"172.5"	"155.2"	"273.9"	"267.0"	"188.5"	"230.2"	"313.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6ZYL4"	"General transcription factor IIH subunit 5 OS=Homo sapiens OX=9606 GN=GTF2H5 PE=1 SV=1"	"41"	"2"	"4"	"2"	"71"	"8.0"	"4.65"	"728.39"	"8.14"	"2"	"2"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	""	"Pf06331"	"404672"	"ENSG00000272047"	"GTF2H5"	"hsa:404672; Q0P5V8; Q6ZYL4"	"Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"NoRC negatively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER"	"32"	"0"	"30.0"	"18.9"	"22.9"	"41.6"	"55.9"	"48.0"	"108.3"	"169.7"	"158.2"	"232.8"	"286.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99590"	"Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2"	"2"	"3"	"5"	"3"	"1463"	"164.6"	"8.41"	"731.06"	"8.14"	"2"	"3"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	""	"9169"	"ENSG00000139218"	"SCAF11"	"A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590"	"Apoptosis"	""	"1"	"0"	"107.8"	"86.3"	"113.8"	"149.4"	"191.3"	"161.2"	"515.7"	"543.4"	"390.3"	"575.7"	"875.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22087"	"rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2"	"10"	"3"	"6"	"3"	"321"	"33.8"	"10.18"	"1021.56"	"8.09"	"3"	"3"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf01269"	"2091"	"ENSG00000105202; ENSG00000280548"	"FBL"	"B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"45.7"	"27.0"	"34.5"	"57.6"	"76.4"	"56.9"	"195.8"	"201.5"	"152.2"	"205.4"	"292.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28074"	"Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3"	"8"	"2"	"4"	"2"	"263"	"28.5"	"6.92"	"964.78"	"8.06"	"2"	"2"	"protein metabolism;other metabolic processes;stress response"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00227"	"5693"	"ENSG00000100804"	"PSMB5"	"B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"96.9"	"51.1"	"86.7"	"104.7"	"143.3"	"130.2"	"291.8"	"295.6"	"154.1"	"237.5"	"469.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95104"	"SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3"	"3"	"3"	"6"	"3"	"1147"	"125.8"	"9.55"	"976.98"	"8.03"	"3"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf04818"	"57466"	"ENSG00000156304"	"SCAF4"	"C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8"	""	""	"0"	"0"	"74.6"	"38.8"	"64.2"	"82.7"	"100.8"	"87.7"	"252.8"	"249.0"	"160.1"	"233.0"	"298.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96C57"	"Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2"	"11"	"2"	"4"	"2"	"262"	"28.2"	"9.42"	"918.85"	"8.01"	"2"	"2"	"cell-cell signaling;signal transduction;other biological processes"	"nucleus"	""	""	"64897"	"ENSG00000157895"	"CUSTOS"	"hsa:64897; Q53HF0; Q96C57; Q9H9Z7"	""	""	"0"	"0"	"27.3"	"17.1"	"27.5"	"29.4"	"47.9"	"36.2"	"176.6"	"149.6"	"106.4"	"121.9"	"137.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43148"	"mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1"	"8"	"4"	"7"	"4"	"476"	"54.8"	"6.61"	"1276.82"	"7.99"	"4"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf03291"	"8731"	"ENSG00000101654"	"RNMT"	"B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9"	"mRNA processing; 15q25 copy number variation"	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE"	"5"	"0"	"221.6"	"136.3"	"233.8"	"349.7"	"419.8"	"359.1"	"835.8"	"791.2"	"500.4"	"580.0"	"843.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BY77"	"Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2"	"7"	"2"	"4"	"2"	"421"	"46.1"	"9.99"	"738.34"	"7.93"	"2"	"2"	"other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"84271"	"ENSG00000100227"	"POLDIP3"	"A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6"	""	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript"	"3"	"0"	"40.1"	"28.8"	"43.3"	"45.7"	"65.0"	"57.0"	"162.2"	"152.7"	"93.4"	"137.5"	"192.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TAT6"	"Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3"	"5"	"2"	"4"	"2"	"608"	"68.1"	"6.38"	"964.78"	"7.92"	"2"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf05020, Pf05021, Pf11543"	"55666"	"ENSG00000182446"	"NPLOC4"	"hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229"	""	"Translesion Synthesis by POLH; Neddylation; KEAP1-NFE2L2 pathway"	"3"	"0"	"70.0"	"40.7"	"68.1"	"94.8"	"114.1"	"104.4"	"204.4"	"211.8"	"135.5"	"156.4"	"184.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14874"	"[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2"	"8"	"3"	"5"	"3"	"412"	"46.3"	"8.82"	"611.69"	"7.89"	"2"	"3"	"protein metabolism;other metabolic processes;other biological processes"	"mitochondrion"	"kinase activity;other molecular function"	"Pf02518, Pf10436"	"10295"	"ENSG00000103507"	"BCKDK"	"A8MY43; hsa:10295; O14874; Q6FGL4; Q96G95; Q96IN5"	"Thiamine metabolic pathways"	"Branched-chain amino acid catabolism"	"2"	"0"	"55.0"	"40.2"	"53.8"	"76.0"	"95.5"	"74.3"	"421.9"	"409.7"	"300.6"	"342.9"	"439.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63173"	"60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2"	"33"	"3"	"7"	"2"	"70"	"8.2"	"10.10"	"908.86"	"7.87"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01781"	"6169"	"ENSG00000172809"	"RPL38"	"B2R5A8; hsa:6169; P23411; P63173"	"Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"16"	"0"	"109.1"	"62.9"	"81.1"	"120.7"	"203.1"	"132.8"	"613.8"	"579.5"	"416.6"	"639.7"	"667.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRT2"	"Ubiquinol-cytochrome-c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1"	"10"	"1"	"4"	"1"	"126"	"14.9"	"7.37"	"733.51"	"7.85"	"1"	"1"	"cell organization and biogenesis;other biological processes"	"other membranes;mitochondrion;nucleus"	""	"Pf20180"	"84300"	"ENSG00000137288"	"UQCC2"	"B2R4I0; hsa:84300; Q9BRT2"	"Mitochondrial complex III assembly"	""	"1"	"0"	"20.5"	"10.8"	"22.8"	"36.0"	"43.8"	"30.3"	"96.3"	"87.6"	"54.8"	"79.5"	"92.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95347"	"Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2"	"3"	"3"	"5"	"3"	"1197"	"135.6"	"8.43"	"632.35"	"7.83"	"2"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02463, Pf06470"	"10592"	"ENSG00000136824"	"SMC2"	"hsa:10592; O95347; Q6IEE0; Q9P1P2"	"Retinoblastoma gene in cancer"	"Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes"	"3"	"0"	"39.8"	"26.8"	"39.0"	"58.3"	"68.1"	"56.9"	"226.0"	"210.6"	"126.9"	"171.7"	"224.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BTD8"	"RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1"	"6"	"3"	"5"	"3"	"480"	"50.4"	"9.63"	"610.19"	"7.81"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"79171"	"ENSG00000126254"	"RBM42"	"hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"179.5"	"131.3"	"165.0"	"222.1"	"293.9"	"236.2"	"678.6"	"581.5"	"393.9"	"536.4"	"597.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15514"	"DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1"	"24"	"2"	"3"	"2"	"142"	"16.3"	"4.79"	"306.65"	"7.78"	"1"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus"	"other molecular function"	"Pf03874"	"5433"	"ENSG00000144231"	"POLR2D"	"hsa:5433; O15514; Q52LT4"	"Pyrimidine metabolism"	"Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"42"	"0"	"51.0"	"32.5"	"50.6"	"75.3"	"76.9"	"73.7"	"186.8"	"189.6"	"106.8"	"138.0"	"170.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43242"	"26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2"	"7"	"2"	"3"	"2"	"534"	"60.9"	"8.44"	"438.65"	"7.78"	"1"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"enzyme regulator activity"	"Pf01399, Pf08375"	"5709"	"ENSG00000108344"	"PSMD3"	"B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"64"	"0"	"8.6"	"3.9"	"8.8"	"10.1"	"17.7"	"10.9"	"25.6"	"22.9"	"12.5"	"14.9"	"16.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13674"	"Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2"	"7"	"4"	"6"	"4"	"534"	"61.0"	"6.01"	"1390.20"	"7.77"	"4"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"ER/Golgi;other cell component"	"other molecular function"	"Pf08336, Pf13640"	"5033"	"ENSG00000122884"	"P4HA1"	"C9JL12; hsa:5033; P13674; Q15082; Q15083; Q5VSQ5"	"Type I collagen synthesis in the context of osteogenesis imperfecta"	"Collagen biosynthesis and modifying enzymes"	"2"	"0"	"78.2"	"62.4"	"92.0"	"155.3"	"152.3"	"136.9"	"287.7"	"278.1"	"181.3"	"231.3"	"328.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61024"	"Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1"	"20"	"2"	"4"	"2"	"79"	"9.7"	"8.94"	"871.68"	"7.75"	"2"	"2"	"cell cycle OR cell proliferation;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf01111"	"1163"	"ENSG00000173207"	"CKS1B"	"hsa:1163; P33551; P61024"	"Small cell lung cancer"	"SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1"	"3"	"0"	"285.8"	"178.3"	"272.5"	"338.2"	"389.9"	"371.3"	"737.7"	"753.0"	"710.9"	"798.6"	"1107.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P83916"	"Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1"	"24"	"3"	"5"	"2"	"185"	"21.4"	"4.93"	"1318.85"	"7.75"	"3"	"2"	"cell organization and biogenesis;stress response;other biological processes"	"cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00385, Pf01393"	"10951"	"ENSG00000108468"	"CBX1"	"hsa:10951; P23197; P83916"	"Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome"	"HCMV Early Events"	"2"	"0"	"64.9"	"44.5"	"63.3"	"76.3"	"80.1"	"85.2"	"159.1"	"169.4"	"100.7"	"146.3"	"208.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14257"	"Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1"	"11"	"2"	"4"	"2"	"317"	"36.9"	"4.40"	"946.06"	"7.74"	"2"	"2"	""	"ER/Golgi;nucleus"	"other molecular function"	"Pf13202"	"5955"	"ENSG00000117906"	"RCN2"	"A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8"	""	""	"0"	"0"	"7.6"	"7.7"	"7.1"	"8.0"	"13.9"	"10.2"	"40.7"	"36.4"	"20.7"	"35.8"	"32.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HD34"	"LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1"	"25"	"2"	"4"	"2"	"91"	"10.8"	"10.73"	"745.44"	"7.69"	"2"	"2"	"cell organization and biogenesis;other metabolic processes"	"cytosol;mitochondrion;nucleus"	"other molecular function"	"Pf05347"	"57128"	"ENSG00000214113"	"LYRM4"	"A8K543; hsa:57128; Q5XKP1; Q9HD34"	"Iron-sulfur cluster biogenesis"	"Mitochondrial iron-sulfur cluster biogenesis"	"2"	"0"	"57.3"	"41.3"	"58.6"	"95.4"	"112.8"	"101.6"	"225.6"	"245.8"	"221.2"	"302.3"	"447.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16537"	"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1"	"6"	"2"	"4"	"2"	"467"	"54.7"	"6.95"	"841.74"	"7.67"	"2"	"2"	"protein metabolism;other metabolic processes;signal transduction"	"cytosol;nucleus;other cell component"	"enzyme regulator activity"	"Pf01603"	"5529"	"ENSG00000154001"	"PPP2R5E"	"A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4"	"Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Negative regulation of MAPK pathway; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Platelet sensitization by LDL; CTLA4 inhibitory signaling"	"28"	"0"	"22.3"	"10.2"	"25.5"	"34.6"	"40.0"	"34.1"	"83.5"	"92.4"	"51.9"	"61.2"	"87.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61586"	"Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1"	"16"	"2"	"4"	"2"	"193"	"21.8"	"6.10"	"673.70"	"7.66"	"2"	"2"	"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00071"	"387"	"ENSG00000067560"	"RHOA"	"hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4"	"Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; Hypothetical craniofacial development pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway"	"Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; VEGFA-VEGFR2 Pathway; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1"	"70"	"0"	"41.9"	"24.6"	"39.7"	"58.9"	"67.5"	"57.8"	"172.7"	"177.3"	"99.2"	"158.2"	"139.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H2P0"	"Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1"	"3"	"3"	"5"	"3"	"1102"	"123.5"	"7.34"	"733.22"	"7.66"	"2"	"3"	"cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00046, Pf19627"	"23394"	"ENSG00000101126"	"ADNP"	"E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34"	""	""	"0"	"0"	"25.0"	"10.7"	"33.2"	"57.4"	"54.1"	"49.4"	"150.9"	"143.4"	"82.8"	"102.2"	"129.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q09666"	"Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2"	"2"	"3"	"6"	"3"	"5890"	"628.7"	"6.15"	"637.43"	"7.62"	"2"	"3"	"other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	""	"79026"	"ENSG00000124942"	"AHNAK"	"A1A586; hsa:79026; Q09666"	""	""	"0"	"0"	"39.7"	"22.8"	"34.1"	"41.9"	"58.3"	"41.2"	"150.3"	"154.8"	"77.3"	"117.0"	"161.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96GD4"	"Aurora kinase B OS=Homo sapiens OX=9606 GN=AURKB PE=1 SV=3"	"7"	"2"	"4"	"2"	"344"	"39.3"	"9.29"	"836.67"	"7.59"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"9212"	"ENSG00000178999"	"AURKB"	"B4DNM4; C7G533; C7G534; C7G535; D3DTR4; hsa:9212; J9JID1; O14630; O60446; O95083; Q96DV5; Q96GD4; Q9UQ46"	"Microtubule cytoskeleton regulation; ATM signaling in development and disease"	"RHO GTPases Activate Formins; Regulation of MECP2 expression and activity; Resolution of Sister Chromatid Cohesion; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Regulation of TP53 Activity through Phosphorylation; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"12"	"0"	"42.9"	"18.1"	"34.8"	"39.5"	"59.2"	"46.7"	"157.6"	"152.1"	"81.6"	"105.2"	"172.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28340"	"DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2"	"3"	"3"	"6"	"3"	"1107"	"123.6"	"7.03"	"928.82"	"7.57"	"3"	"3"	"DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00136, Pf03104, Pf14260"	"5424"	"ENSG00000062822"	"POLD1"	"hsa:5424; P28340; Q8NER3; Q96H98"	"Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair"	"Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"	"27"	"0"	"63.6"	"62.6"	"67.1"	"114.0"	"149.2"	"115.2"	"239.9"	"319.2"	"233.1"	"254.9"	"265.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61289"	"Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1"	"12"	"3"	"6"	"3"	"254"	"29.5"	"5.95"	"909.95"	"7.57"	"3"	"3"	"cell cycle OR cell proliferation;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf02251, Pf02252"	"10197"	"ENSG00000131467"	"PSME3"	"A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9"	"Proteasome degradation"	"Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Separation of Sister Chromatids; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling"	"60"	"0"	"158.8"	"112.1"	"137.8"	"267.3"	"328.4"	"271.7"	"495.7"	"571.6"	"483.4"	"589.3"	"860.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00257"	"E3 SUMO-protein ligase CBX4 OS=Homo sapiens OX=9606 GN=CBX4 PE=1 SV=3"	"6"	"3"	"6"	"3"	"560"	"61.3"	"9.36"	"831.42"	"7.57"	"3"	"3"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00385, Pf17218"	"8535"	"ENSG00000141582"	"CBX4"	"B1PJR7; hsa:8535; O00257; Q6TPI8; Q96C04"	""	"SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription"	"8"	"0"	"60.4"	"47.2"	"55.3"	"70.4"	"91.0"	"74.3"	"313.3"	"299.1"	"274.7"	"286.3"	"411.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P02533"	"Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4"	"8"	"5"	"9"	"2"	"472"	"51.5"	"5.16"	"1884.64"	"7.57"	"5"	"3"	"cell organization and biogenesis;other biological processes"	"plasma membrane;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00038"	"3861"	"ENSG00000186847"	"KRT14"	"hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4"	"Corticotropin-releasing hormone signaling pathway"	"Formation of the cornified envelope; Type I hemidesmosome assembly"	"4"	"0"	"267.5"	"117.4"	"117.8"	"110.7"	"658.2"	"192.3"	"223.6"	"852.7"	"138.7"	"205.8"	"225.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKX7"	"Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2"	"8"	"3"	"5"	"3"	"468"	"50.1"	"7.06"	"626.20"	"7.56"	"2"	"3"	"transport"	"other membranes;nucleus"	""	"Pf00638, Pf08911"	"10762"	"ENSG00000093000"	"NUP50"	"B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; Regulation of HSF1-mediated heat shock response; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"28"	"0"	"35.2"	"31.3"	"30.0"	"50.1"	"54.5"	"47.1"	"99.5"	"102.5"	"77.1"	"74.9"	"110.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBQ7"	"Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1"	"7"	"1"	"2"	"1"	"328"	"35.6"	"7.39"	""	"7.56"	""	"1"	"other metabolic processes"	"cytosol;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00389, Pf02826"	"9380"	"ENSG00000137106"	"GRHPR"	"hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1"	""	"Glyoxylate metabolism and glycine degradation"	"1"	"0"	"9.5"	"9.9"	"9.9"	"12.8"	"13.3"	"13.4"	"27.8"	"24.0"	"14.5"	"19.8"	"34.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00291"	"Huntingtin-interacting protein 1 OS=Homo sapiens OX=9606 GN=HIP1 PE=1 SV=5"	"5"	"5"	"7"	"5"	"1037"	"116.1"	"5.30"	"1629.83"	"7.55"	"5"	"2"	"cell organization and biogenesis;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf01608, Pf07651, Pf16515"	"3092"	"ENSG00000127946"	"HIP1"	"B4E3I7; E7ES17; hsa:3092; O00291; O00328; Q2TB58; Q8TDL4; V5LU97"	"DYRK1A involvement regarding cell proliferation in brain development; 5q35 copy number variation"	"Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants"	"5"	"0"	"282.4"	"157.6"	"282.1"	"441.6"	"531.8"	"425.9"	"829.2"	"792.6"	"443.3"	"537.5"	"860.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62306"	"Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1"	"22"	"2"	"6"	"2"	"86"	"9.7"	"4.67"	"1388.26"	"7.54"	"2"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf01423"	"6636"	"ENSG00000139343"	"SNRPF"	"A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0"	"mRNA processing"	"snRNP Assembly; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"	"8"	"0"	"170.3"	"130.1"	"158.4"	"217.2"	"272.0"	"275.4"	"884.8"	"794.2"	"551.9"	"687.3"	"960.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9ULP9"	"TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2"	"5"	"2"	"4"	"2"	"559"	"62.9"	"7.36"	"614.54"	"7.53"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;other cell component"	"enzyme regulator activity"	"Pf00566, Pf07534"	"57465"	"ENSG00000162065"	"TBC1D24"	"A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9"	""	"TBC/RABGAPs"	"1"	"0"	"0.0"	"0.0"	"3.0"	"7.7"	"5.8"	"7.5"	"14.5"	"20.2"	"29.9"	"88.3"	"177.2"	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51858"	"Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1"	"11"	"2"	"3"	"2"	"240"	"26.8"	"4.73"	"654.24"	"7.53"	"1"	"2"	"cell organization and biogenesis;signal transduction;other biological processes"	"nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00855"	"3068"	"ENSG00000143321"	"HDGF"	"B3KU21; D3DVC9; hsa:3068; P51858; Q5SZ07; Q5SZ08; Q5SZ09"	"IL-18 signaling pathway"	"XBP1(S) activates chaperone genes"	"2"	"0"	"92.3"	"57.4"	"81.0"	"97.5"	"139.5"	"125.9"	"262.7"	"256.8"	"132.7"	"216.0"	"281.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3C6"	"Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1"	"30"	"4"	"8"	"4"	"166"	"18.2"	"7.99"	"1441.24"	"7.47"	"4"	"3"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes"	"nucleus"	"other molecular function"	"Pf00160"	"51645"	"ENSG00000137168"	"PPIL1"	"hsa:51645; O15001; Q5TDC9; Q9Y3C6"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"170.4"	"131.4"	"167.5"	"202.3"	"255.2"	"253.4"	"583.0"	"552.2"	"396.6"	"542.7"	"874.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14868"	"Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2"	"8"	"3"	"7"	"3"	"501"	"57.1"	"6.55"	"1254.94"	"7.41"	"3"	"2"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf00152, Pf01336"	"1615"	"ENSG00000115866"	"DARS1"	"A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52"	"Alanine and aspartate metabolism"	"Selenoamino acid metabolism; Cytosolic tRNA aminoacylation"	"3"	"0"	"38.2"	"30.6"	"39.3"	"63.0"	"71.5"	"61.7"	"117.6"	"108.7"	"69.6"	"100.2"	"123.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25208"	"Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2"	"8"	"1"	"4"	"1"	"207"	"22.8"	"4.59"	"1022.69"	"7.40"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00808"	"4801"	"ENSG00000120837"	"NFYB"	"A8K7B9; hsa:4801; P25208; Q96IY8"	""	"PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes"	"5"	"0"	"19.7"	"20.3"	"23.5"	"41.2"	"41.4"	"36.3"	"84.9"	"70.7"	"54.4"	"69.7"	"91.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11233"	"Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1"	"10"	"2"	"5"	"2"	"206"	"23.6"	"7.11"	"1044.15"	"7.38"	"2"	"1"	"cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;mitochondrion;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00071"	"5898"	"ENSG00000006451"	"RALA"	"A4D1W3; hsa:5898; P11233"	"RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway"	"Translocation of SLC2A4 (GLUT4) to the plasma membrane; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; p38MAPK events"	"8"	"0"	"40.5"	"19.8"	"36.9"	"46.9"	"55.5"	"41.8"	"139.9"	"125.7"	"53.6"	"97.0"	"169.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13555"	"Calcium/calmodulin-dependent protein kinase type II subunit gamma OS=Homo sapiens OX=9606 GN=CAMK2G PE=1 SV=4"	"8"	"3"	"5"	"1"	"558"	"62.6"	"7.83"	"1014.74"	"7.37"	"3"	"2"	"cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069, Pf08332"	"818"	"ENSG00000148660"	"CAMK2G"	"A0A0A0MS52; A0A0A0MT11; hsa:818; O00561; O15378; Q13279; Q13282; Q13555; Q13556; Q5SQZ3; Q5SQZ4; Q5SWX4; Q7KYX5; Q8N4I3; Q8NIA4"	"Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway"	"Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"	"31"	"0"	"7.3"	"3.4"	"8.4"	"12.0"	"9.1"	"11.1"	"19.4"	"18.1"	"9.7"	"17.1"	"29.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60885"	"Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2"	"2"	"2"	"4"	"2"	"1362"	"152.1"	"9.19"	"822.64"	"7.35"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf00439, Pf17035, Pf17105"	"23476"	"ENSG00000141867"	"BRD4"	"hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3"	"VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome"	"Potential therapeutics for SARS"	"3"	"0"	"37.9"	"25.1"	"44.6"	"60.1"	"86.5"	"51.4"	"191.1"	"180.1"	"124.3"	"137.4"	"181.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00231"	"26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3"	"8"	"2"	"3"	"2"	"422"	"47.4"	"6.48"	"560.46"	"7.35"	"1"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"other molecular function"	"Pf01399, Pf18055, Pf18503"	"5717"	"ENSG00000108671"	"PSMD11"	"A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5"	"Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling"	"Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"63"	"0"	"21.0"	"14.9"	"22.6"	"33.6"	"38.4"	"31.4"	"63.8"	"49.3"	"34.6"	"63.3"	"59.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2A7"	"Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1"	"2"	"3"	"6"	"3"	"1128"	"128.7"	"6.62"	"804.25"	"7.32"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	""	"Pf09735"	"10787"	"ENSG00000061676"	"NCKAP1"	"hsa:10787; O60329; Q53QN5; Q53S94; Q53Y35; Q9Y2A7"	"Exercise-induced circadian regulation; Regulation of actin cytoskeleton"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway"	"9"	"0"	"86.4"	"60.5"	"88.5"	"107.1"	"130.7"	"111.2"	"538.4"	"526.7"	"367.0"	"486.7"	"741.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y265"	"RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1"	"7"	"3"	"6"	"3"	"456"	"50.2"	"6.42"	"848.84"	"7.30"	"3"	"3"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf06068, Pf17856"	"8607"	"ENSG00000175792; ENSG00000284901"	"RUVBL1"	"B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265"	"Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer"	"DNA Damage Recognition in GG-NER; UCH proteinases; Ub-specific processing proteases; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones; Telomere Extension By Telomerase"	"9"	"0"	"43.7"	"26.9"	"38.7"	"44.4"	"71.0"	"51.1"	"101.3"	"104.2"	"55.8"	"98.6"	"118.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P1U0"	"DNA-directed RNA polymerase I subunit RPA12 OS=Homo sapiens OX=9606 GN=ZNRD1 PE=1 SV=1"	"19"	"2"	"3"	"2"	"126"	"13.9"	"5.06"	"292.22"	"7.30"	"1"	"2"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01096"	"30834"	"ENSG00000066379; ENSG00000206502; ENSG00000224859; ENSG00000233795; ENSG00000235176; ENSG00000235443; ENSG00000236808; ENSG00000236949"	"POLR1H"	"hsa:30834; Q9P1U0"	"Pyrimidine metabolism; 2q13 copy number variation syndrome"	"RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination"	"7"	"0"	"50.0"	"31.8"	"47.5"	"66.4"	"88.1"	"79.8"	"224.0"	"407.7"	"340.0"	"585.6"	"731.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13769"	"THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2"	"4"	"3"	"5"	"3"	"683"	"78.5"	"6.87"	"591.07"	"7.30"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf09766"	"8563"	"ENSG00000100296"	"THOC5"	"hsa:8563; O60839; Q13769; Q9UPZ5"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Signaling by CSF1 (M-CSF) in myeloid cells"	"4"	"0"	"103.1"	"91.3"	"105.2"	"159.6"	"200.9"	"172.9"	"409.7"	"388.8"	"224.5"	"333.4"	"426.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96EI5"	"Transcription elongation factor A protein-like 4 OS=Homo sapiens OX=9606 GN=TCEAL4 PE=1 SV=2"	"17"	"3"	"4"	"3"	"215"	"24.6"	"5.20"	"615.87"	"7.29"	"2"	"2"	""	"nucleus"	""	"Pf04538"	"79921"	"ENSG00000133142"	"TCEAL4"	"hsa:79921; Q8WY12; Q96EI5; Q9H2H1; Q9H775"	""	""	"0"	"0"	"173.1"	"80.3"	"162.4"	"321.9"	"348.5"	"311.9"	"639.9"	"615.2"	"393.7"	"408.5"	"566.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BTZ2"	"Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3"	"11"	"3"	"6"	"3"	"278"	"29.5"	"8.56"	"848.00"	"7.28"	"3"	"3"	"other metabolic processes;other biological processes"	"other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle"	"other molecular function"	"Pf13561"	"10901"	"ENSG00000157326; ENSG00000284807"	"DHRS4"	"B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08"	""	"Peroxisomal protein import; RA biosynthesis pathway"	"2"	"0"	"55.2"	"36.2"	"47.6"	"83.7"	"103.0"	"93.9"	"188.4"	"184.0"	"118.4"	"174.5"	"220.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96DV4"	"39S ribosomal protein L38, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2"	"7"	"2"	"6"	"2"	"380"	"44.6"	"7.53"	"898.96"	"7.26"	"2"	"2"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	""	"Pf01161"	"64978"	"ENSG00000204316"	"MRPL38"	"B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"73.7"	"52.9"	"78.0"	"118.3"	"136.6"	"105.3"	"246.3"	"231.4"	"141.1"	"166.4"	"286.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49720"	"Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2"	"15"	"2"	"4"	"2"	"205"	"22.9"	"6.55"	"766.19"	"7.25"	"2"	"2"	"protein metabolism;other metabolic processes"	"cytosol;nucleus;other cell component"	""	"Pf00227"	"5691"	"ENSG00000275903; ENSG00000277791"	"PSMB3"	"hsa:5691; P31147; P49720; Q0P6J7; Q96E27"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"33.6"	"26.6"	"38.3"	"48.1"	"56.3"	"54.7"	"124.8"	"115.4"	"74.6"	"108.3"	"141.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49454"	"Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3"	"1"	"2"	"4"	"2"	"3114"	"357.3"	"5.10"	"769.21"	"7.25"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf10473, Pf10481, Pf10490"	"1063"	"ENSG00000117724"	"CENPF"	"hsa:1063; P49454; Q13171; Q13246; Q5VVM7"	"Gastric cancer network 1; Ciliopathies"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Polo-like kinase mediated events"	"9"	"0"	"37.8"	"20.9"	"37.4"	"53.7"	"51.4"	"46.7"	"162.6"	"161.9"	"103.0"	"137.8"	"190.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UQR0"	"Sex comb on midleg-like protein 2 OS=Homo sapiens OX=9606 GN=SCML2 PE=1 SV=1"	"5"	"2"	"4"	"2"	"700"	"77.2"	"8.54"	"679.19"	"7.24"	"2"	"2"	"other biological processes"	"nucleus"	""	"Pf00536, Pf02820, Pf12140, Pf17208"	"10389"	"ENSG00000102098"	"SCML2"	"hsa:10389; Q5JXE6; Q86U98; Q8IWD0; Q8NDP2; Q9UGC5; Q9UQR0"	""	""	"0"	"0"	"5.6"	"4.9"	"8.3"	"7.3"	"8.5"	"12.6"	"29.6"	"25.3"	"17.6"	"23.5"	"35.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28070"	"Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4"	"13"	"2"	"3"	"2"	"264"	"29.2"	"5.97"	"364.21"	"7.23"	"1"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00227"	"5692"	"ENSG00000159377"	"PSMB4"	"B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"52.7"	"30.7"	"55.0"	"64.8"	"83.6"	"71.7"	"197.9"	"195.8"	"138.1"	"175.6"	"238.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15291"	"Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2"	"3"	"2"	"6"	"2"	"538"	"59.1"	"5.10"	"930.73"	"7.21"	"2"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00400"	"5929"	"ENSG00000117222"	"RBBP5"	"A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7"	"Kleefstra syndrome"	"Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"	"8"	"0"	"59.5"	"52.3"	"73.8"	"85.8"	"113.7"	"107.3"	"262.4"	"291.5"	"179.1"	"256.6"	"403.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92900"	"Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2"	"3"	"2"	"4"	"2"	"1129"	"124.3"	"6.61"	"853.18"	"7.21"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf09416, Pf13086, Pf13087, Pf18141"	"5976"	"ENSG00000005007"	"UPF1"	"hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900"	"Pathophysiological roles of DUX4 in FSHD1"	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"3"	"0"	"31.0"	"18.8"	"32.9"	"45.9"	"55.0"	"54.8"	"156.4"	"129.7"	"105.9"	"127.5"	"151.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19022"	"Cadherin-2 OS=Homo sapiens OX=9606 GN=CDH2 PE=1 SV=4"	"3"	"2"	"3"	"2"	"906"	"99.7"	"4.81"	"433.82"	"7.14"	"1"	"2"	"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;ER/Golgi;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00028, Pf01049, Pf08758"	"1000"	"ENSG00000170558"	"CDH2"	"A8MWK3; B0YIY6; hsa:1000; P19022; Q14923; Q8N173"	"Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Splicing factor NOVA regulated synaptic proteins; Epithelial to mesenchymal transition in colorectal cancer; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; A network map of Macrophage-stimulating protein (MSP) signaling"	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Myogenesis; Adherens junctions interactions"	"16"	"0"	"64.0"	"35.9"	"48.1"	"79.6"	"85.3"	"70.2"	"166.0"	"147.8"	"85.0"	"146.9"	"170.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30041"	"Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3"	"13"	"3"	"7"	"3"	"224"	"25.0"	"6.38"	"1308.14"	"7.14"	"3"	"3"	"other metabolic processes;stress response;other biological processes"	"non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00578, Pf10417"	"9588"	"ENSG00000117592"	"PRDX6"	"A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8"	"Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling"	"Neutrophil degranulation; Detoxification of Reactive Oxygen Species"	"5"	"0"	"282.1"	"234.0"	"288.9"	"339.3"	"446.9"	"435.8"	"734.7"	"635.1"	"392.1"	"601.7"	"1061.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P47813"	"Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2"	"15"	"3"	"5"	"3"	"144"	"16.5"	"5.24"	"985.20"	"7.12"	"3"	"2"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity"	"Pf01176"	"1964"	"ENSG00000173674"	"EIF1AX"	"B2R5U5; hsa:1964; P47813; Q0VGC2; Q5JPS5; Q5JPS6"	"Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell"	"L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition"	"8"	"0"	"372.5"	"228.2"	"376.8"	"367.3"	"489.2"	"423.7"	"1189.7"	"1137.0"	"744.7"	"890.9"	"1451.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96J01"	"THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1"	"8"	"3"	"5"	"3"	"351"	"38.7"	"6.09"	"684.86"	"7.11"	"2"	"3"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00400, Pf08662, Pf12894"	"84321"	"ENSG00000051596"	"THOC3"	"hsa:84321; Q6NZ53; Q96J01"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"3"	"0"	"34.7"	"17.9"	"41.1"	"44.1"	"63.5"	"51.1"	"128.6"	"124.9"	"56.7"	"91.3"	"141.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82650"	"28S ribosomal protein S22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1"	"5"	"2"	"5"	"2"	"360"	"41.3"	"7.90"	"616.87"	"7.09"	"1"	"2"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf10245"	"56945"	"ENSG00000175110"	"MRPS22"	"hsa:56945; P82650; Q9H3I1"	"Primary ovarian insufficiency"	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"4"	"0"	"142.3"	"84.7"	"139.7"	"177.6"	"192.5"	"172.4"	"350.5"	"305.5"	"194.5"	"242.4"	"267.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BV38"	"WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2"	"6"	"2"	"4"	"2"	"432"	"47.4"	"6.70"	"859.15"	"7.08"	"2"	"2"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	""	"Pf00400, Pf14077"	"57418"	"ENSG00000065268"	"WDR18"	"hsa:57418; O60390; Q9BV38; Q9BWR2"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"49.6"	"40.3"	"60.9"	"77.1"	"75.4"	"75.8"	"173.5"	"159.6"	"106.5"	"142.3"	"164.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BQ39"	"ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1"	"5"	"3"	"5"	"3"	"737"	"82.5"	"9.17"	"1069.24"	"7.06"	"3"	"2"	""	"plasma membrane;other membranes;nucleus"	"other molecular function"	"Pf00270, Pf00271, Pf08152"	"79009"	"ENSG00000107625"	"DDX50"	"hsa:79009; Q5VX37; Q8WV76; Q9BQ39; Q9BWI8"	""	""	"0"	"0"	"61.4"	"41.9"	"46.3"	"65.1"	"82.1"	"59.8"	"174.2"	"141.5"	"87.2"	"145.9"	"178.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16630"	"Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2"	"7"	"2"	"2"	"2"	"551"	"59.2"	"7.15"	""	"7.06"	""	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00076"	"11052"	"ENSG00000111605"	"CPSF6"	"A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18"	""	"Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease"	"2"	"0"	"54.6"	"36.0"	"49.1"	"60.0"	"79.3"	"64.8"	"169.5"	"202.9"	"209.3"	"287.6"	"298.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95639"	"Cleavage and polyadenylation specificity factor subunit 4 OS=Homo sapiens OX=9606 GN=CPSF4 PE=1 SV=1"	"13"	"2"	"3"	"2"	"269"	"30.2"	"8.31"	"367.18"	"7.06"	"1"	"2"	""	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00098, Pf00642, Pf15663"	"10898"	"ENSG00000160917"	"CPSF4"	"D6W5S8; hsa:10898; O95639; Q6FGE6; Q86TF8; Q9BTW6"	"mRNA processing"	"Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing"	"8"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NE71"	"ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2"	"4"	"2"	"4"	"2"	"845"	"95.9"	"6.80"	"917.89"	"7.05"	"2"	"2"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00005, Pf12848"	"23"	"ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342"	"ABCF1"	"A2BF75; hsa:23; O14897; Q69YP6; Q8NE71"	"IL-18 signaling pathway"	"ABC-family proteins mediated transport"	"2"	"0"	"34.6"	"13.0"	"28.6"	"38.5"	"63.8"	"39.8"	"222.4"	"245.7"	"68.0"	"150.0"	"314.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07919"	"Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2"	"42"	"4"	"6"	"4"	"91"	"10.7"	"4.44"	"1346.25"	"6.99"	"4"	"2"	"other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity"	"Pf02320"	"7388"	"ENSG00000173660"	"UQCRH"	"B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly"	"Respiratory electron transport"	"4"	"0"	"399.1"	"262.0"	"379.5"	"489.4"	"542.5"	"482.4"	"991.7"	"976.2"	"558.5"	"751.6"	"848.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q53F19"	"Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2"	"3"	"2"	"6"	"2"	"620"	"70.5"	"5.73"	"925.13"	"6.96"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes;stress response;transport"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf10309"	"55421"	"ENSG00000074356"	"NCBP3"	"B3KWG7; hsa:55421; Q53F19; Q7L406; Q96FK1; Q9NXZ4"	""	""	"0"	"0"	"17.2"	"13.8"	"23.1"	"26.8"	"43.0"	"35.0"	"89.6"	"84.3"	"46.7"	"78.4"	"89.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86W42"	"THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1"	"12"	"2"	"3"	"2"	"341"	"37.5"	"7.43"	"328.91"	"6.95"	"1"	"2"	"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00400"	"79228"	"ENSG00000131652"	"THOC6"	"B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"3"	"0"	"41.2"	"23.8"	"41.8"	"48.6"	"63.3"	"54.2"	"119.0"	"117.6"	"67.2"	"99.7"	"122.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00308"	"NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2"	"2"	"2"	"6"	"2"	"870"	"98.9"	"7.12"	"769.85"	"6.95"	"2"	"2"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00397, Pf00632"	"11060"	"ENSG00000198373"	"WWP2"	"A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; hsa:11060; I3RSG8; O00308; Q6ZTQ5; Q96CZ2; Q9BWN6"	""	"RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle"	"5"	"0"	"5.0"	"2.7"	"10.7"	"9.4"	"10.7"	"12.6"	"21.7"	"19.9"	"14.5"	"18.0"	"33.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVM9"	"Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2"	"6"	"3"	"4"	"3"	"706"	"80.2"	"6.70"	"693.72"	"6.92"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf10221"	"55726"	"ENSG00000064102"	"INTS13"	"B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9"	"1p36 copy number variation syndrome"	"RNA polymerase II transcribes snRNA genes"	"2"	"0"	"79.7"	"58.4"	"82.9"	"133.5"	"158.0"	"121.7"	"257.5"	"251.2"	"146.9"	"184.5"	"263.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HAV0"	"Guanine nucleotide-binding protein subunit beta-4 OS=Homo sapiens OX=9606 GN=GNB4 PE=1 SV=3"	"9"	"2"	"4"	"1"	"340"	"37.5"	"6.00"	"635.72"	"6.91"	"2"	"2"	"signal transduction"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf00400"	"59345"	"ENSG00000114450"	"GNB4"	"B3KMH5; D3DNR8; hsa:59345; Q9HAV0"	"Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells"	"G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation"	"34"	"0"	"20.7"	"15.7"	"23.3"	"28.4"	"36.8"	"28.1"	"55.2"	"56.1"	"36.9"	"58.7"	"66.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BTL3"	"RNA guanine-N7 methyltransferase activating subunit OS=Homo sapiens OX=9606 GN=RAMAC PE=1 SV=1"	"19"	"2"	"4"	"2"	"118"	"14.4"	"8.94"	"985.67"	"6.88"	"2"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf15320"	"83640"	"ENSG00000169612"	"RAMAC"	"hsa:83640; Q2M1J8; Q9BTL3"	"15q25 copy number variation"	""	"1"	"0"	"79.3"	"72.8"	"91.3"	"119.0"	"159.2"	"125.5"	"292.4"	"301.8"	"208.1"	"261.1"	"273.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18206"	"Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4"	"2"	"3"	"6"	"3"	"1134"	"123.7"	"5.66"	"793.71"	"6.85"	"3"	"3"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf01044"	"7414"	"ENSG00000035403"	"VCL"	"hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7"	"Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton"	"Neutrophil degranulation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Platelet degranulation ; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants"	"18"	"0"	"26.2"	"15.8"	"22.8"	"36.1"	"50.0"	"46.2"	"67.6"	"75.3"	"42.9"	"59.9"	"89.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UJV9"	"Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2"	"8"	"4"	"6"	"4"	"622"	"69.8"	"6.84"	"951.63"	"6.84"	"3"	"3"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf00270, Pf00271"	"51428"	"ENSG00000183258"	"DDX41"	"B2RDC8; hsa:51428; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9"	"5q35 copy number variation"	"mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN"	"5"	"0"	"16.4"	"12.3"	"20.7"	"22.7"	"32.3"	"21.0"	"72.5"	"76.2"	"44.4"	"61.7"	"77.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96SB4"	"SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2"	"5"	"2"	"3"	"2"	"655"	"74.3"	"6.16"	"337.42"	"6.77"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"6732"	"ENSG00000096063"	"SRPK1"	"B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4"	"VEGFA-VEGFR2 signaling; mRNA processing"	"Maturation of nucleoprotein"	"3"	"0"	"20.0"	"6.9"	"25.7"	"22.0"	"31.7"	"29.8"	"88.5"	"94.1"	"51.4"	"72.8"	"87.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14562"	"ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1"	"3"	"3"	"5"	"3"	"1220"	"139.2"	"8.32"	"1020.79"	"6.77"	"3"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus"	"other molecular function"	"Pf00271, Pf00575, Pf04408, Pf07717"	"1659"	"ENSG00000067596"	"DHX8"	"hsa:1659; Q14562"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"20.1"	"12.0"	"19.1"	"25.4"	"27.7"	"28.5"	"75.8"	"83.0"	"49.3"	"58.4"	"81.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P00403"	"Cytochrome c oxidase subunit 2 OS=Homo sapiens OX=9606 GN=MT-CO2 PE=1 SV=1"	"12"	"3"	"4"	"3"	"227"	"25.5"	"4.82"	"771.15"	"6.75"	"2"	"2"	"other metabolic processes;stress response;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf00116, Pf02790"	"4513"	"ENSG00000198712"	"MT-CO2"	"hsa:4513; P00403; Q37526"	"Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway; 5q35 copy number variation"	"Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1"	"11"	"0"	"83.1"	"59.8"	"62.6"	"76.3"	"118.9"	"90.5"	"166.1"	"145.8"	"101.0"	"174.1"	"186.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKY7"	"Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1"	"9"	"2"	"4"	"2"	"258"	"27.3"	"6.40"	"644.87"	"6.70"	"2"	"2"	""	"plasma membrane;other membranes;cytosol;other cell component"	""	"Pf15359"	"55573"	"ENSG00000091527"	"CDV3"	"B3KUC2; hsa:55573; Q96IP9; Q9UKY7"	""	""	"0"	"0"	"144.5"	"120.2"	"124.2"	"185.3"	"214.2"	"199.7"	"352.1"	"346.6"	"262.3"	"333.9"	"453.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86T24"	"Transcriptional regulator Kaiso OS=Homo sapiens OX=9606 GN=ZBTB33 PE=1 SV=2"	"4"	"2"	"3"	"2"	"672"	"74.4"	"5.12"	"480.52"	"6.68"	"1"	"2"	"cell-cell signaling;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00651"	"10009"	"ENSG00000177485"	"ZBTB33"	"B2R5U6; hsa:10009; O00319; Q7Z361; Q86T24; Q8IVP6; Q8N3P0"	"Wnt signaling pathway and pluripotency"	""	"1"	"0"	"44.5"	"41.7"	"50.4"	"100.6"	"105.3"	"89.4"	"204.9"	"189.0"	"134.6"	"147.5"	"174.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13492"	"Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2"	"4"	"2"	"3"	"2"	"652"	"70.7"	"7.90"	"382.60"	"6.66"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf07651"	"8301"	"ENSG00000073921"	"PICALM"	"B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9"	""	"Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle"	"4"	"0"	"52.9"	"39.2"	"51.1"	"97.2"	"95.2"	"78.5"	"251.3"	"329.6"	"313.7"	"644.3"	"1394.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BZF1"	"Oxysterol-binding protein-related protein 8 OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=3"	"3"	"2"	"4"	"2"	"889"	"101.1"	"6.96"	"666.45"	"6.65"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"transporter activity;other molecular function"	"Pf00169, Pf01237"	"114882"	"ENSG00000091039"	"OSBPL8"	"A8K1T2; E9PE66; E9PE68; hsa:114882; Q52LQ3; Q68D75; Q8WXP8; Q9BZF1; Q9P277"	""	"Acyl chain remodelling of PS"	"1"	"0"	"4.7"	"3.1"	"3.4"	"4.5"	"6.6"	"4.5"	"29.5"	"34.7"	"27.5"	"35.4"	"45.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UFW8"	"CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2"	"12"	"2"	"4"	"2"	"167"	"18.8"	"8.95"	"567.83"	"6.64"	"2"	"2"	"cell organization and biogenesis;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	""	"8545"	"ENSG00000163320"	"CGGBP1"	"D3DU38; hsa:8545; O15183; Q9UFW8"	""	""	"0"	"0"	"58.4"	"33.9"	"55.7"	"73.7"	"90.5"	"76.7"	"283.2"	"284.6"	"191.6"	"206.4"	"274.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O96000"	"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 OS=Homo sapiens OX=9606 GN=NDUFB10 PE=1 SV=3"	"14"	"2"	"4"	"2"	"172"	"20.8"	"8.48"	"664.25"	"6.63"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity"	"Pf10249"	"4716"	"ENSG00000140990"	"NDUFB10"	"hsa:4716; O96000; Q96II6"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation"	"Complex I biogenesis"	"6"	"0"	"64.1"	"48.6"	"69.1"	"86.7"	"98.6"	"88.2"	"187.9"	"149.5"	"113.9"	"139.1"	"181.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H6R4"	"Nucleolar protein 6 OS=Homo sapiens OX=9606 GN=NOL6 PE=1 SV=2"	"1"	"1"	"4"	"1"	"1146"	"127.5"	"7.64"	"668.06"	"6.61"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"mitochondrion;nucleus;other cell component"	""	"Pf03813, Pf17403, Pf17404, Pf17405, Pf17406, Pf17407"	"65083"	"ENSG00000165271"	"NOL6"	"hsa:65083; Q5T5M3; Q5T5M4; Q7L4G6; Q8N6I0; Q8TEY9; Q8TEZ0; Q8TEZ1; Q9H675; Q9H6R4"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"9.9"	"8.1"	"14.3"	"18.9"	"21.6"	"14.2"	"33.2"	"34.0"	"24.8"	"34.4"	"49.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61244"	"Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1"	"13"	"2"	"4"	"2"	"160"	"18.3"	"6.30"	"754.55"	"6.58"	"2"	"2"	"cell organization and biogenesis;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00010"	"4149"	"ENSG00000125952"	"MAX"	"A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8"	"B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation"	"Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry"	"11"	"0"	"24.6"	"18.4"	"24.3"	"38.2"	"51.9"	"36.3"	"90.9"	"106.5"	"63.6"	"93.1"	"155.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14676"	"Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3"	"1"	"2"	"4"	"2"	"2089"	"226.5"	"5.47"	"663.27"	"6.58"	"2"	"2"	"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	""	"Pf00498, Pf16770"	"9656"	"ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095"	"MDC1"	"A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2"	"ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome"	"SUMOylation of DNA damage response and repair proteins; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)"	"9"	"0"	"26.5"	"24.5"	"35.4"	"45.8"	"44.7"	"47.7"	"109.7"	"101.6"	"70.8"	"97.9"	"115.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BSD7"	"Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1"	"14"	"2"	"4"	"2"	"190"	"20.7"	"9.54"	"700.78"	"6.57"	"2"	"2"	""	""	"other molecular function"	"Pf03266"	"84284"	"ENSG00000135778"	"NTPCR"	"hsa:84284; Q9BSD7"	""	""	"0"	"0"	"27.1"	"24.6"	"35.7"	"35.9"	"42.7"	"44.8"	"144.0"	"145.9"	"106.5"	"136.1"	"202.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99633"	"Pre-mRNA-splicing factor 18 OS=Homo sapiens OX=9606 GN=PRPF18 PE=1 SV=1"	"14"	"3"	"3"	"3"	"342"	"39.8"	"8.15"	"493.94"	"6.57"	"1"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf02840, Pf08799"	"8559"	"ENSG00000165630"	"PRPF18"	"hsa:8559; Q5T9P9; Q99633; Q9BUI9"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"17.6"	"9.8"	"21.1"	"25.6"	"37.6"	"27.2"	"99.6"	"99.8"	"63.5"	"100.5"	"154.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6P587"	"Acylpyruvase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=2"	"13"	"2"	"4"	"2"	"224"	"24.8"	"7.39"	"721.08"	"6.49"	"2"	"2"	"other metabolic processes"	"cytosol;mitochondrion;nucleus"	"other molecular function"	"Pf01557"	"81889"	"ENSG00000180185"	"FAHD1"	"B1AK40; B1AK41; hsa:81889; Q6FIC7; Q6P587; Q96RY1; Q9H0N6"	""	"Citric acid cycle (TCA cycle)"	"1"	"0"	"50.7"	"41.7"	"50.7"	"72.8"	"83.1"	"74.5"	"172.9"	"164.3"	"104.4"	"146.3"	"224.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52435"	"DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1"	"17"	"2"	"4"	"2"	"117"	"13.3"	"5.86"	"828.14"	"6.46"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf13656"	"5439"	"ENSG00000005075"	"POLR2J"	"A5D6V8; hsa:5439; O43375; P52435"	"Pyrimidine metabolism; Eukaryotic transcription initiation"	"mRNA Splicing - Major Pathway; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Inhibition of DNA recombination at telomere"	"43"	"0"	"101.2"	"67.6"	"91.8"	"106.3"	"123.1"	"126.9"	"241.1"	"243.2"	"165.7"	"178.3"	"290.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52815"	"39S ribosomal protein L12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2"	"13"	"2"	"4"	"2"	"198"	"21.3"	"8.87"	"689.97"	"6.43"	"2"	"2"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other membranes;mitochondrion;translational apparatus"	"nucleic acid binding activity;other molecular function"	"Pf00542, Pf16320"	"6182"	"ENSG00000262814"	"MRPL12"	"hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"32.2"	"13.3"	"28.2"	"48.7"	"63.5"	"51.8"	"135.9"	"134.8"	"76.1"	"97.5"	"118.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NQT4"	"Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1"	"9"	"2"	"4"	"2"	"235"	"25.2"	"7.59"	"776.01"	"6.39"	"2"	"2"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01138, Pf03725"	"56915"	"ENSG00000077348"	"EXOSC5"	"hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"6"	"0"	"78.5"	"52.5"	"78.7"	"114.8"	"137.5"	"108.8"	"290.3"	"269.4"	"186.2"	"255.0"	"310.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96GC5"	"39S ribosomal protein L48, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL48 PE=1 SV=2"	"11"	"2"	"4"	"2"	"212"	"23.9"	"8.98"	"698.50"	"6.38"	"2"	"2"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	""	"Pf00338"	"51642"	"ENSG00000175581"	"MRPL48"	"B4DN34; hsa:51642; Q49AK7; Q4U2Q4; Q96GC5; Q9P091; Q9Y5J0"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"50.9"	"30.6"	"43.9"	"78.6"	"82.9"	"70.1"	"155.1"	"156.6"	"100.1"	"127.0"	"213.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P21953"	"2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2"	"8"	"2"	"4"	"2"	"392"	"43.1"	"6.29"	"626.04"	"6.36"	"2"	"2"	"other metabolic processes;other biological processes"	"mitochondrion;nucleus"	"other molecular function"	"Pf02779, Pf02780"	"594"	"ENSG00000083123"	"BCKDHB"	"hsa:594; P21953; Q5T2J3; Q9BQL0"	"Primary ovarian insufficiency"	"Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism"	"3"	"0"	"27.5"	"21.4"	"35.1"	"38.3"	"43.3"	"40.9"	"90.2"	"112.1"	"80.8"	"105.6"	"108.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P56192"	"Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2"	"4"	"2"	"3"	"2"	"900"	"101.1"	"6.16"	"332.23"	"6.35"	"1"	"2"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00043, Pf00458, Pf09334, Pf18485, Pf19303"	"4141"	"ENSG00000166986"	"MARS1"	"B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0"	""	"Selenoamino acid metabolism; Cytosolic tRNA aminoacylation"	"2"	"0"	"24.9"	"14.8"	"17.5"	"26.6"	"36.0"	"32.1"	"46.6"	"46.9"	"31.9"	"38.4"	"46.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55036"	"26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1"	"6"	"2"	"4"	"2"	"377"	"40.7"	"4.79"	"724.35"	"6.34"	"2"	"2"	"protein metabolism;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf02809, Pf13519"	"5710"	"ENSG00000159352"	"PSMD4"	"D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease"	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"64"	"0"	"74.4"	"64.2"	"89.5"	"112.5"	"155.0"	"112.2"	"258.6"	"243.8"	"163.6"	"213.7"	"247.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HCD5"	"Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2"	"4"	"2"	"4"	"2"	"579"	"65.5"	"9.60"	"756.81"	"6.33"	"2"	"2"	"signal transduction;other biological processes"	"cytoskeleton;nucleus"	"other molecular function"	""	"57727"	"ENSG00000124160"	"NCOA5"	"B2RTV9; E1P5R0; hsa:57727; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5"	""	""	"0"	"0"	"27.3"	"22.0"	"23.4"	"25.7"	"37.4"	"32.0"	"101.9"	"102.2"	"97.0"	"166.4"	"246.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P32322"	"Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2"	"10"	"3"	"6"	"2"	"319"	"33.3"	"7.61"	"1286.24"	"6.31"	"3"	"2"	"other metabolic processes;stress response;other biological processes"	"mitochondrion"	"other molecular function"	"Pf03807, Pf14748"	"5831"	"ENSG00000183010"	"PYCR1"	"A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4"	"Amino acid metabolism; Metabolic reprogramming in colon cancer"	"Glutamate and glutamine metabolism"	"3"	"0"	"203.6"	"117.7"	"192.4"	"216.7"	"275.4"	"216.3"	"625.6"	"577.4"	"359.0"	"467.5"	"616.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P24941"	"Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2"	"7"	"2"	"3"	"1"	"298"	"33.9"	"8.68"	"463.56"	"6.30"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"1017"	"ENSG00000123374"	"CDK2"	"A8K7C6; hsa:1017; O75100; P24941"	"miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response"	"Senescence-Associated Secretory Phenotype (SASP); Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle"	"47"	"0"	"8.8"	"10.0"	"17.0"	"21.9"	"17.1"	"18.3"	"55.2"	"60.8"	"35.2"	"44.2"	"70.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14950"	"Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2"	"17"	"2"	"4"	"2"	"172"	"19.8"	"4.84"	"836.95"	"6.29"	"2"	"2"	"other biological processes"	"cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf08976, Pf13405"	"103910; 10627"	"ENSG00000118680"	"MYL12B"	"D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4"	"Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion"	"RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs"	"9"	"0"	"40.8"	"32.3"	"40.4"	"55.1"	"58.8"	"53.7"	"135.4"	"132.3"	"85.5"	"113.7"	"164.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61962"	"DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1"	"6"	"2"	"4"	"2"	"342"	"38.9"	"5.52"	"614.20"	"6.29"	"2"	"2"	"protein metabolism;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00400"	"10238"	"ENSG00000136485"	"DCAF7"	"B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4"	"Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development"	"Neddylation; Association of TriC/CCT with target proteins during biosynthesis"	"4"	"0"	"118.1"	"114.1"	"145.3"	"180.3"	"230.7"	"220.0"	"363.9"	"411.8"	"289.8"	"332.7"	"406.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60231"	"Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2"	"3"	"2"	"4"	"2"	"1041"	"119.2"	"6.80"	"716.65"	"6.28"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes;stress response"	"nucleus;other cell component"	"other molecular function"	"Pf00270, Pf00271, Pf04408, Pf07717"	"8449"	"ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561"	"DHX16"	"hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"12.2"	"8.9"	"14.3"	"14.4"	"22.5"	"16.9"	"40.9"	"41.2"	"27.0"	"38.6"	"47.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35659"	"Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1"	"5"	"2"	"4"	"2"	"375"	"42.6"	"8.56"	"641.03"	"6.28"	"2"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytoskeleton;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf08766"	"7913"	"ENSG00000124795"	"DEK"	"B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5"	"IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"	"5"	"0"	"90.8"	"54.8"	"84.7"	"95.8"	"122.4"	"114.9"	"647.4"	"552.8"	"375.5"	"507.0"	"746.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRJ7"	"Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1"	"13"	"2"	"4"	"2"	"211"	"23.3"	"8.91"	"731.47"	"6.27"	"2"	"2"	"other biological processes"	"nucleus"	"nucleic acid binding activity"	""	"84309"	"ENSG00000168101"	"NUDT16L1"	"hsa:84309; Q8NAI2; Q9BRJ7"	""	""	"0"	"0"	"18.5"	"11.6"	"19.9"	"34.6"	"37.8"	"31.1"	"109.8"	"110.4"	"52.0"	"74.4"	"127.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O76003"	"Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2"	"7"	"2"	"4"	"2"	"335"	"37.4"	"5.39"	"598.44"	"6.27"	"2"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00085, Pf00462"	"10539"	"ENSG00000108010"	"GLRX3"	"B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1"	""	"Iron uptake and transport"	"1"	"0"	"60.1"	"47.0"	"79.1"	"112.0"	"140.1"	"105.9"	"172.3"	"158.7"	"120.7"	"159.5"	"178.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IUF8"	"Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1"	"5"	"2"	"4"	"2"	"465"	"52.8"	"6.70"	"522.10"	"6.26"	"2"	"2"	"cell organization and biogenesis;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf08007, Pf20514"	"84864"	"ENSG00000170854"	"RIOX2"	"D3DN35; hsa:84864; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0"	""	"HDMs demethylate histones"	"1"	"0"	"32.8"	"23.3"	"37.2"	"40.0"	"58.7"	"44.3"	"196.6"	"204.4"	"193.2"	"224.4"	"245.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5T8P6"	"RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3"	"3"	"2"	"4"	"2"	"1007"	"113.5"	"9.16"	"655.37"	"6.24"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf01480"	"64062"	"ENSG00000139746"	"RBM26"	"B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7"	""	""	"0"	"0"	"7.9"	"3.8"	"13.2"	"14.5"	"17.5"	"13.9"	"31.7"	"30.3"	"17.6"	"27.4"	"31.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q06587"	"E3 ubiquitin-protein ligase RING1 OS=Homo sapiens OX=9606 GN=RING1 PE=1 SV=2"	"11"	"2"	"3"	"2"	"406"	"42.4"	"5.62"	"508.32"	"6.23"	"1"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00097, Pf16207"	"6015"	"ENSG00000204227; ENSG00000206287; ENSG00000226788; ENSG00000228520; ENSG00000231115; ENSG00000235107"	"RING1"	"A8JZZ0; hsa:6015; Q06587; Q5JP96; Q5SQW2; Q86V19"	"Pleural mesothelioma; Notch signaling pathway"	"Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6"	"11"	"0"	"15.0"	"10.8"	"20.1"	"27.5"	"31.1"	"24.5"	"63.0"	"61.3"	"41.2"	"47.1"	"60.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z3B4"	"Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2"	"6"	"2"	"4"	"2"	"507"	"55.4"	"7.02"	"650.47"	"6.20"	"2"	"2"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;nucleus"	"other molecular function"	"Pf13874, Pf18437"	"53371"	"ENSG00000138750"	"NUP54"	"B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1"	""	"SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Regulation of HSF1-mediated heat shock response; snRNP Assembly; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation"	"29"	"0"	"54.3"	"33.6"	"61.7"	"86.3"	"110.3"	"74.5"	"207.2"	"217.8"	"127.6"	"178.6"	"229.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P58546"	"Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2"	"6"	"1"	"4"	"1"	"118"	"12.9"	"5.52"	"539.80"	"6.19"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity"	"Pf12796"	"136319"	"ENSG00000105887"	"MTPN"	"hsa:136319; P58546"	""	""	"0"	"0"	"87.5"	"57.0"	"99.1"	"113.0"	"139.5"	"132.9"	"258.9"	"253.5"	"196.9"	"253.7"	"445.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07948"	"Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3"	"4"	"2"	"4"	"1"	"512"	"58.5"	"7.11"	"692.67"	"6.18"	"2"	"2"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function"	"Pf00017, Pf00018, Pf07714"	"4067"	"ENSG00000254087"	"LYN"	"A0AVQ5; hsa:4067; P07948"	"IL-5 signaling pathway; RANKL/RANK signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; GDNF signaling"	"FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; EPHB-mediated forward signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; CD28 co-stimulation; PECAM1 interactions; CTLA4 inhibitory signaling; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; Cyclin D associated events in G1; Growth hormone receptor signaling; Inactivation of CSF3 (G-CSF) signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; Dectin-2 family"	"45"	"0"	"34.6"	"21.3"	"32.9"	"43.5"	"49.6"	"39.3"	"89.3"	"92.3"	"50.9"	"77.9"	"103.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z7K0"	"COX assembly mitochondrial protein homolog OS=Homo sapiens OX=9606 GN=CMC1 PE=1 SV=1"	"25"	"2"	"3"	"2"	"106"	"12.5"	"8.63"	"314.28"	"6.15"	"1"	"2"	""	"mitochondrion"	"other molecular function"	"Pf08583"	"152100"	"ENSG00000187118"	"CMC1"	"hsa:152100; Q68DJ7; Q7Z7K0"	"Mitochondrial complex IV assembly"	""	"1"	"0"	"54.3"	"33.5"	"59.0"	"81.0"	"108.2"	"75.1"	"424.4"	"385.7"	"192.5"	"282.7"	"315.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62891"	"60S ribosomal protein L39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2"	"20"	"1"	"4"	"1"	"51"	"6.4"	"12.56"	"592.37"	"6.13"	"1"	"1"	"protein metabolism;other metabolic processes;stress response"	"non-structural extracellular;cytosol;translational apparatus"	"nucleic acid binding activity;other molecular function"	"Pf00832"	"6170"	"ENSG00000198918"	"RPL39"	"hsa:6170; P02404; P39025; P62891; Q9BYF2"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"27.5"	"20.8"	"27.0"	"37.7"	"38.7"	"38.7"	"173.7"	"186.8"	"83.8"	"118.6"	"116.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18669"	"Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2"	"14"	"2"	"3"	"2"	"254"	"28.8"	"7.18"	"450.44"	"6.11"	"1"	"2"	"other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;other cell component"	"other molecular function"	"Pf00300"	"5223"	"ENSG00000171314"	"PGAM1"	"hsa:5223; P18669; Q9BWC0"	"Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Neutrophil degranulation; Glycolysis; Gluconeogenesis"	"8"	"0"	"17.3"	"26.1"	"24.8"	"28.6"	"26.0"	"33.7"	"66.1"	"76.7"	"46.1"	"66.9"	"111.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13952"	"Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3"	"7"	"3"	"5"	"3"	"458"	"50.3"	"6.10"	"953.05"	"6.10"	"3"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00125"	"4802"	"ENSG00000066136"	"NFYC"	"B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7"	""	"PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes"	"5"	"0"	"85.3"	"72.1"	"107.6"	"186.1"	"224.2"	"187.5"	"341.5"	"320.9"	"235.6"	"290.2"	"409.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15007"	"Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2"	"9"	"2"	"4"	"2"	"396"	"44.2"	"5.19"	"625.49"	"6.10"	"2"	"2"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"other membranes;nucleus;other cell component"	"other molecular function"	"Pf17098"	"9589"	"ENSG00000146457"	"WTAP"	"hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2"	""	"Processing of Capped Intron-Containing Pre-mRNA"	"1"	"0"	"20.0"	"13.7"	"21.6"	"24.5"	"31.8"	"34.7"	"60.1"	"58.8"	"28.7"	"49.1"	"76.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60520"	"Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1"	"16"	"2"	"4"	"2"	"117"	"13.7"	"8.10"	"748.41"	"6.09"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf02991"	"11345"	"ENSG00000034713"	"GABARAPL2"	"hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7"	"Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome"	"Macroautophagy; TBC/RABGAPs"	"4"	"0"	"69.9"	"55.6"	"74.2"	"118.0"	"145.2"	"124.8"	"313.7"	"408.4"	"242.1"	"338.5"	"843.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15436"	"Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2"	"3"	"2"	"4"	"2"	"765"	"86.1"	"7.08"	"683.38"	"6.09"	"2"	"2"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033"	"10484"	"ENSG00000100934"	"SEC23A"	"B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16"	"Sterol regulatory element-binding proteins (SREBP) signaling"	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII-mediated vesicle transport; SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)"	"7"	"0"	"19.8"	"16.7"	"29.9"	"34.3"	"45.9"	"39.3"	"152.6"	"176.0"	"130.7"	"170.4"	"204.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3U8"	"60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3"	"25"	"3"	"5"	"3"	"105"	"12.2"	"11.59"	"1008.48"	"6.08"	"3"	"2"	"protein metabolism;other metabolic processes"	"cytosol;translational apparatus;nucleus"	"other molecular function"	"Pf01158"	"25873"	"ENSG00000130255"	"RPL36"	"B2R4Y1; D6W634; hsa:25873; Q6FIG1; Q9UQF6; Q9Y3U8"	"Cytoplasmic ribosomal proteins"	"Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"176.4"	"91.1"	"148.6"	"188.5"	"222.0"	"218.3"	"1013.6"	"928.4"	"568.0"	"779.8"	"1071.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBU8"	"Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2"	"5"	"2"	"4"	"2"	"362"	"41.4"	"9.28"	"693.83"	"6.07"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf05712, Pf11717"	"10933"	"ENSG00000185787"	"MORF4L1"	"B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8"	"Pathways affected in adenoid cystic carcinoma"	"HATs acetylate histones"	"2"	"0"	"35.1"	"26.4"	"38.1"	"59.4"	"65.5"	"53.8"	"355.5"	"359.0"	"312.6"	"375.9"	"371.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99436"	"Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1"	"11"	"3"	"5"	"3"	"277"	"29.9"	"7.68"	"938.43"	"6.07"	"3"	"2"	"protein metabolism;other metabolic processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00227, Pf12465"	"5695"	"ENSG00000136930"	"PSMB7"	"B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"ER-Phagosome pathway; Neutrophil degranulation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"63"	"0"	"156.8"	"105.9"	"134.5"	"172.4"	"239.0"	"193.9"	"613.0"	"628.2"	"409.7"	"453.6"	"575.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y333"	"U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1"	"16"	"2"	"5"	"2"	"95"	"10.8"	"6.52"	"1033.68"	"6.06"	"2"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01423"	"57819"	"ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826"	"LSM2"	"hsa:57819; Q6FGG1; Q9Y333"	"mRNA processing"	"mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease"	"3"	"0"	"184.1"	"148.6"	"215.6"	"262.6"	"337.6"	"340.7"	"942.0"	"851.1"	"609.7"	"789.6"	"1047.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96QC0"	"Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1"	"3"	"3"	"5"	"3"	"940"	"99.0"	"9.17"	"865.58"	"6.02"	"3"	"2"	"transport;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00642, Pf08711"	"5514"	"ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104"	"PPP1R10"	"hsa:5514; O00405; Q96QC0"	""	""	"0"	"0"	"108.2"	"63.1"	"88.4"	"130.4"	"150.2"	"141.6"	"401.3"	"391.2"	"260.6"	"345.0"	"452.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6P5R6"	"60S ribosomal protein L22-like 1 OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2"	"25"	"2"	"3"	"2"	"122"	"14.6"	"9.38"	"311.48"	"5.95"	"1"	"2"	"protein metabolism;other metabolic processes"	"translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01776"	"200916"	"ENSG00000163584"	"RPL22L1"	"hsa:200916; Q32Q77; Q6P5R6"	""	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"13"	"0"	"34.7"	"21.3"	"27.1"	"54.1"	"63.8"	"51.3"	"396.4"	"419.1"	"220.3"	"316.6"	"464.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95747"	"Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1"	"4"	"2"	"2"	"2"	"527"	"58.0"	"6.43"	""	"5.94"	""	"2"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;other cell component"	"kinase activity;other molecular function"	"Pf00069, Pf12202"	"9943"	"ENSG00000172939"	"OXSR1"	"hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1"	""	""	"0"	"0"	"3.7"	"2.1"	"6.5"	"5.0"	"5.3"	"7.1"	"17.8"	"16.2"	"9.6"	"20.5"	"76.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6WKZ4"	"Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3"	"3"	"3"	"5"	"3"	"1283"	"137.1"	"5.43"	"1004.28"	"5.94"	"3"	"2"	"transport;other biological processes"	"other membranes;cytosol;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00168, Pf09457"	"80223"	"ENSG00000156675"	"RAB11FIP1"	"hsa:80223; J3KNP0; Q307T1; Q6AZK4; Q6WKZ2; Q6WKZ4; Q6WKZ6; Q86YV4; Q8TDL1; Q9H642"	""	""	"0"	"0"	"109.8"	"67.5"	"96.9"	"159.1"	"202.3"	"166.0"	"499.9"	"883.7"	"847.0"	"1048.4"	"1001.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P21912"	"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3"	"8"	"2"	"4"	"2"	"280"	"31.6"	"8.76"	"609.85"	"5.91"	"2"	"2"	"other metabolic processes"	"plasma membrane;other membranes;mitochondrion;nucleus"	"other molecular function"	"Pf13085, Pf13534"	"6390"	"ENSG00000117118"	"SDHB"	"B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12"	"Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)"	"Respiratory electron transport; Citric acid cycle (TCA cycle)"	"7"	"0"	"70.6"	"73.9"	"82.6"	"101.5"	"127.3"	"118.3"	"279.0"	"313.2"	"219.9"	"304.4"	"443.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19623"	"Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1"	"8"	"2"	"4"	"2"	"302"	"33.8"	"5.49"	"779.25"	"5.88"	"2"	"2"	"other metabolic processes;other biological processes"	"cytosol"	"other molecular function"	"Pf01564, Pf17284"	"6723"	"ENSG00000116649"	"SRM"	"B1AKP9; hsa:6723; P19623; Q15511"	"Methionine de novo and salvage pathway; Amino acid metabolism"	"Metabolism of polyamines"	"3"	"0"	"75.3"	"73.4"	"76.3"	"114.4"	"148.1"	"120.3"	"188.5"	"178.9"	"151.3"	"172.8"	"256.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49773"	"Histidine triad nucleotide-binding protein 1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2"	"17"	"2"	"4"	"2"	"126"	"13.8"	"6.95"	"688.80"	"5.88"	"2"	"2"	"protein metabolism;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf01230"	"3094"	"ENSG00000169567"	"HINT1"	"hsa:3094; P49773; Q9H5W8"	""	""	"0"	"0"	"183.3"	"153.1"	"181.0"	"188.3"	"224.8"	"221.8"	"433.4"	"425.4"	"305.0"	"359.6"	"522.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15212"	"Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1"	"16"	"2"	"4"	"2"	"129"	"14.6"	"8.88"	"650.53"	"5.88"	"2"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"other cell component"	"other molecular function"	"Pf01920"	"10471"	"ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335"	"PFDN6"	"hsa:10471; O15212"	"Cellular proteostasis"	"Prefoldin mediated transfer of substrate  to CCT/TriC"	"2"	"0"	"29.3"	"23.8"	"32.8"	"46.9"	"53.9"	"45.5"	"101.0"	"101.8"	"70.7"	"88.1"	"125.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NEF9"	"Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1"	"6"	"2"	"4"	"2"	"429"	"48.6"	"9.58"	"661.95"	"5.87"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	""	"Pf09073"	"153443"	"ENSG00000151304"	"SRFBP1"	"hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2"	""	""	"0"	"0"	"23.2"	"23.5"	"27.0"	"34.2"	"42.3"	"41.4"	"119.2"	"105.8"	"76.8"	"95.9"	"111.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBC2"	"Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1"	"2"	"2"	"4"	"2"	"864"	"94.2"	"5.11"	"614.05"	"5.85"	"2"	"2"	"transport"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf12763"	"58513"	"ENSG00000127527"	"EPS15L1"	"A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2"	"EGF/EGFR signaling pathway"	"Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation"	"4"	"0"	"58.6"	"36.3"	"62.9"	"116.7"	"133.4"	"108.0"	"260.4"	"260.4"	"176.1"	"261.9"	"372.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NX63"	"MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1"	"8"	"2"	"4"	"2"	"227"	"26.1"	"8.28"	"745.61"	"5.85"	"2"	"2"	"cell organization and biogenesis"	"other membranes;mitochondrion;nucleus"	"other molecular function"	"Pf05300"	"54927"	"ENSG00000106554"	"CHCHD3"	"hsa:54927; Q9NX63"	""	"Cristae formation; Mitochondrial protein import"	"2"	"0"	"135.2"	"72.5"	"93.9"	"123.2"	"199.0"	"158.5"	"360.0"	"281.3"	"106.1"	"246.8"	"306.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y530"	"ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2"	"13"	"2"	"4"	"2"	"152"	"17.0"	"8.31"	"626.62"	"5.84"	"2"	"2"	"protein metabolism;other metabolic processes;stress response"	"nucleus;other cell component"	"other molecular function"	"Pf01661"	"221443"	"ENSG00000124596"	"OARD1"	"A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530"	""	""	"0"	"0"	"33.5"	"27.8"	"41.2"	"48.6"	"54.6"	"42.8"	"141.0"	"152.4"	"128.0"	"160.1"	"188.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P83881"	"60S ribosomal protein L36a OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2"	"22"	"3"	"4"	"3"	"106"	"12.4"	"10.58"	"578.53"	"5.83"	"2"	"2"	"protein metabolism;other metabolic processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus"	"other molecular function"	"Pf00935"	"6173"	"ENSG00000241343"	"RPL36A"	"hsa:6173; P09896; P10661; P83881; Q08ES5; Q5J9I6"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"362.4"	"228.2"	"341.0"	"364.7"	"480.4"	"406.5"	"2241.0"	"1936.7"	"1328.6"	"1675.8"	"1620.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5L4"	"Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1"	"12"	"1"	"4"	"1"	"95"	"10.5"	"8.18"	"515.40"	"5.79"	"1"	"1"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;mitochondrion;nucleus"	"other molecular function"	"Pf02953"	"26517"	"ENSG00000099800"	"TIMM13"	"hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4"	""	"Mitochondrial protein import"	"1"	"0"	"0.0"	"2.4"	"5.5"	"5.7"	"8.0"	"5.1"	"33.0"	"32.4"	"17.2"	"25.9"	"24.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96HS1"	"Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2"	"8"	"2"	"4"	"2"	"289"	"32.0"	"8.68"	"673.28"	"5.76"	"2"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;mitochondrion"	"enzyme regulator activity;other molecular function"	"Pf00300"	"192111"	"ENSG00000247077"	"PGAM5"	"A9LN06; C9IZY7; hsa:192111; Q96HS1; Q96JB0"	"NRF2-ARE regulation"	""	"1"	"0"	"80.4"	"65.6"	"75.8"	"105.6"	"130.4"	"133.2"	"277.3"	"267.3"	"179.3"	"240.1"	"279.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35222"	"Catenin beta-1 OS=Homo sapiens OX=9606 GN=CTNNB1 PE=1 SV=1"	"4"	"3"	"5"	"2"	"781"	"85.4"	"5.86"	"984.23"	"5.76"	"3"	"2"	"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00514"	"1499"	"ENSG00000168036"	"CTNNB1"	"A8K1L7; hsa:1499; P35222; Q8NEW9; Q8NI94; Q9H391"	"Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Heart development; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Gastric cancer network 2; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Endoderm differentiation; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Focal adhesion; Ectoderm differentiation; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; OSX and miRNAs in tooth development; Wnt signaling pathway and pluripotency; PTF1A related regulatory pathway; Wnt signaling in kidney disease; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Genes controlling nephrogenesis; GDNF/RET signaling axis; Mammalian disorder of sexual development; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; 1q21.1 copy number variation syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system; Pleural mesothelioma; Alzheimer's disease; Urotensin-II-mediated signaling pathway; Markers of kidney cell lineage; TROP2 regulatory signaling; 8p23.1 copy number variation syndrome; A network map of Macrophage-stimulating protein (MSP) signaling; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response (only ATM dependent)"	"Somitogenesis; Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; RHO GTPases activate IQGAPs; Formation of paraxial mesoderm; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Formation of axial mesoderm; Myogenesis; Transcriptional Regulation by VENTX; Ca2+ pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Apoptotic cleavage of cell adhesion  proteins; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"	"96"	"1"	"161.7"	"92.4"	"120.8"	"172.9"	"220.2"	"204.6"	"304.3"	"334.7"	"173.3"	"258.9"	"319.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVA1"	"Ubiquinol-cytochrome-c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3"	"7"	"2"	"4"	"2"	"299"	"34.6"	"8.91"	"595.69"	"5.76"	"2"	"2"	"cell organization and biogenesis"	"other membranes;mitochondrion;other cell component"	""	"Pf03981"	"55245"	"ENSG00000101019"	"UQCC1"	"B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1"	"Ciliary landscape; Mitochondrial complex III assembly"	""	"2"	"0"	"16.7"	"5.0"	"12.4"	"28.6"	"27.5"	"17.8"	"80.5"	"76.8"	"40.1"	"63.5"	"110.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14160"	"Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=4"	"1"	"2"	"4"	"2"	"1630"	"174.8"	"5.07"	"739.46"	"5.75"	"2"	"2"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"60.6"	"52.5"	"61.1"	"83.9"	"101.7"	"83.6"	"160.0"	"174.1"	"112.7"	"144.3"	"156.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BQ67"	"Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1"	"5"	"2"	"4"	"2"	"446"	"49.4"	"4.92"	"542.45"	"5.73"	"2"	"2"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00400, Pf12265"	"83743"	"ENSG00000105447"	"GRWD1"	"A0MNN5; hsa:83743; Q8TF59; Q9BQ67"	""	""	"0"	"0"	"69.0"	"45.8"	"62.2"	"81.4"	"118.7"	"89.7"	"238.4"	"237.2"	"147.2"	"184.3"	"216.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82933"	"28S ribosomal protein S9, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2"	"3"	"1"	"4"	"1"	"396"	"45.8"	"9.51"	"544.01"	"5.70"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	"other molecular function"	"Pf00380"	"64965"	"ENSG00000135972"	"MRPS9"	"hsa:64965; P82933; Q6PG40"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"19.9"	"17.5"	"30.4"	"28.4"	"41.2"	"28.6"	"78.5"	"79.3"	"55.2"	"69.0"	"81.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6A4"	"Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1"	"10"	"2"	"4"	"2"	"193"	"22.8"	"9.76"	"574.05"	"5.68"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytoskeleton;nucleus;other cell component"	""	"Pf05018"	"29105"	"ENSG00000070761"	"CFAP20"	"hsa:29105; Q9Y6A4"	""	""	"0"	"0"	"64.9"	"47.8"	"63.5"	"76.9"	"103.3"	"95.6"	"227.3"	"203.5"	"154.0"	"244.5"	"283.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62875"	"DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1"	"30"	"2"	"3"	"2"	"67"	"7.6"	"7.77"	"352.27"	"5.67"	"1"	"2"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01194"	"5441"	"ENSG00000177700"	"POLR2L"	"hsa:5441; P52436; P62875; Q6FHX3"	"Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome"	"Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; Cytosolic sensors of pathogen-associated DNA ; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"56"	"0"	"29.2"	"17.4"	"28.4"	"27.3"	"49.3"	"42.9"	"112.9"	"137.4"	"114.8"	"163.5"	"187.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P54727"	"UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1"	"6"	"3"	"5"	"1"	"409"	"43.1"	"4.84"	"954.29"	"5.66"	"3"	"2"	"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00240, Pf00627, Pf09280"	"5887"	"ENSG00000119318"	"RAD23B"	"B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0"	"Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"Formation of Incision Complex in GG-NER; Josephin domain DUBs; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle"	"7"	"0"	"72.7"	"46.2"	"78.1"	"112.4"	"121.6"	"111.1"	"241.7"	"220.3"	"135.6"	"186.5"	"240.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99460"	"26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2"	"1"	"1"	"3"	"1"	"953"	"105.8"	"5.39"	"478.45"	"5.64"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf01851, Pf13646, Pf18004"	"5707"	"ENSG00000173692"	"PSMD1"	"B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"64"	"0"	"48.2"	"29.3"	"41.3"	"55.2"	"72.4"	"52.9"	"110.3"	"120.5"	"66.3"	"89.7"	"105.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q69YN2"	"CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2"	"5"	"2"	"4"	"2"	"538"	"60.6"	"7.24"	"649.16"	"5.62"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"enzyme regulator activity"	"Pf04676, Pf04677"	"55280"	"ENSG00000095485"	"CWF19L1"	"B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13"	""	""	"0"	"0"	"16.2"	"9.2"	"16.2"	"16.1"	"29.1"	"21.8"	"47.3"	"51.6"	"34.3"	"47.7"	"65.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95299"	"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA10 PE=1 SV=1"	"8"	"2"	"4"	"2"	"355"	"40.7"	"8.48"	"674.35"	"5.60"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;transport"	"other membranes;mitochondrion;other cell component"	"transporter activity"	"Pf01712"	"4705"	"ENSG00000130414"	"NDUFA10"	"hsa:4705; O95299; Q8WXC9"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; 2q37 copy number variation syndrome; Oxidative phosphorylation"	"Complex I biogenesis"	"6"	"0"	"15.3"	"4.5"	"13.5"	"22.6"	"27.5"	"21.7"	"66.9"	"65.8"	"36.8"	"45.2"	"43.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92759"	"General transcription factor IIH subunit 4 OS=Homo sapiens OX=9606 GN=GTF2H4 PE=1 SV=1"	"3"	"1"	"4"	"1"	"462"	"52.2"	"9.04"	"560.41"	"5.60"	"1"	"1"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf03849, Pf18307"	"2968"	"ENSG00000213780; ENSG00000221974; ENSG00000226384; ENSG00000233149; ENSG00000234370; ENSG00000236895"	"GTF2H4"	"B4DTJ5; hsa:2968; Q76KU4; Q92759"	"Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"RNA Polymerase I Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination"	"33"	"0"	"6.8"	"3.9"	"9.1"	"18.3"	"13.3"	"17.9"	"34.8"	"57.6"	"46.0"	"62.0"	"102.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96DG6"	"Carboxymethylenebutenolidase homolog OS=Homo sapiens OX=9606 GN=CMBL PE=1 SV=1"	"7"	"2"	"4"	"2"	"245"	"28.0"	"7.18"	"605.74"	"5.59"	"2"	"2"	"other metabolic processes"	"cytosol"	"other molecular function"	"Pf01738"	"134147"	"ENSG00000164237"	"CMBL"	"D3DTC7; hsa:134147; Q8TED6; Q96DG6"	""	"Phase I - Functionalization of compounds"	"1"	"0"	"77.2"	"53.0"	"77.6"	"108.3"	"151.3"	"112.5"	"192.1"	"195.0"	"132.4"	"184.3"	"226.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P40429"	"60S ribosomal protein L13a OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2"	"12"	"3"	"5"	"3"	"203"	"23.6"	"10.93"	"910.01"	"5.59"	"3"	"2"	"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00572"	"23521"	"ENSG00000142541"	"RPL13A"	"A8K505; hsa:23521; P40429"	"VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"15"	"0"	"122.4"	"84.5"	"122.1"	"159.3"	"191.5"	"165.4"	"830.9"	"743.5"	"477.7"	"621.5"	"798.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75489"	"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1"	"15"	"3"	"4"	"3"	"264"	"30.2"	"7.50"	"963.30"	"5.58"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion;nucleus"	"transporter activity;other molecular function"	"Pf00329"	"4722"	"ENSG00000213619; ENSG00000285387"	"NDUFS3"	"B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"RHOG GTPase cycle; Complex I biogenesis"	"6"	"0"	"50.6"	"29.2"	"47.9"	"54.0"	"75.2"	"59.5"	"122.1"	"102.7"	"76.2"	"110.0"	"131.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49757"	"Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2"	"2"	"1"	"4"	"1"	"651"	"70.8"	"8.51"	"552.94"	"5.57"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00640, Pf06311"	"8650"	"ENSG00000133961"	"NUMB"	"B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4"	"Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway"	"Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus"	"10"	"0"	"17.6"	"14.6"	"20.7"	"22.0"	"38.1"	"26.7"	"81.7"	"115.4"	"99.3"	"126.4"	"155.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30084"	"Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4"	"9"	"2"	"3"	"2"	"290"	"31.4"	"8.07"	"358.45"	"5.55"	"1"	"2"	"other metabolic processes"	"mitochondrion"	"other molecular function"	"Pf00378"	"1892"	"ENSG00000127884"	"ECHS1"	"hsa:1892; O00739; P30084; Q5VWY1; Q96H54"	"Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism"	"Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"	"10"	"0"	"69.1"	"44.6"	"69.9"	"81.0"	"101.9"	"97.7"	"284.7"	"270.5"	"138.5"	"214.6"	"360.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P12931"	"Proto-oncogene tyrosine-protein kinase Src OS=Homo sapiens OX=9606 GN=SRC PE=1 SV=3"	"6"	"3"	"5"	"1"	"536"	"59.8"	"7.42"	"1114.74"	"5.55"	"3"	"2"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function"	"Pf00017, Pf00018, Pf07714"	"6714"	"ENSG00000197122"	"SRC"	"E1P5V4; hsa:6714; P12931; Q76P87; Q86VB9; Q9H5A8"	"Androgen receptor signaling pathway; Angiogenesis; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Aryl hydrocarbon receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Robo4 and VEGF signaling pathways crosstalk; Fibrin complement receptor 3 signaling pathway; Acute viral myocarditis; NRF2-ARE regulation; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; A network map of Macrophage-stimulating protein (MSP) signaling; 5q35 copy number variation; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway"	"Regulation of RUNX3 expression and activity; G alpha (i) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; PIP3 activates AKT signaling; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DCC mediated attractive signaling; Downstream signal transduction; Signaling by ERBB2; Nuclear signaling by ERBB4; RAF activation; GAB1 signalosome; MET activates PTK2 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; Long-term potentiation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of commissural axon pathfinding by SLIT and ROBO; Netrin mediated repulsion signals; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Activated NTRK2 signals through FYN; Downregulation of ERBB4 signaling; Regulation of RUNX1 Expression and Activity; Activated NTRK3 signals through PI3K"	"87"	"0"	"10.1"	"12.6"	"20.0"	"21.8"	"28.4"	"29.0"	"44.4"	"42.1"	"36.2"	"40.1"	"59.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07947"	"Tyrosine-protein kinase Yes OS=Homo sapiens OX=9606 GN=YES1 PE=1 SV=3"	"6"	"3"	"5"	"1"	"543"	"60.8"	"6.74"	"989.94"	"5.55"	"3"	"2"	"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi"	"signal transduction activity or receptor binding;kinase activity;other molecular function"	"Pf00017, Pf00018, Pf07714"	"7525"	"ENSG00000176105"	"YES1"	"A6NLB3; D3DUH1; hsa:7525; P07947"	"Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; NRF2-ARE regulation; Gastrin signaling pathway; GDNF signaling"	"FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; EPHB-mediated forward signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; Signaling by ERBB2; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; CD28 co-stimulation; PECAM1 interactions; CTLA4 inhibitory signaling"	"22"	"2"	"145.5"	"105.7"	"110.9"	"172.6"	"231.4"	"204.0"	"382.3"	"368.1"	"224.8"	"307.7"	"484.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q08378"	"Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2"	"2"	"2"	"4"	"2"	"1498"	"167.3"	"5.44"	"577.53"	"5.53"	"2"	"2"	""	"other membranes;cytosol;ER/Golgi;nucleus"	""	""	"2802"	"ENSG00000090615"	"GOLGA3"	"A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3"	""	"RND2 GTPase cycle"	"1"	"0"	"3.6"	"0.0"	"5.5"	"7.9"	"8.2"	"7.9"	"16.1"	"16.0"	"10.7"	"16.1"	"22.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5T1J5"	"Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD2P9 PE=5 SV=1"	"19"	"1"	"1"	"1"	"151"	"15.5"	"9.89"	""	"5.52"	""	"1"	"cell organization and biogenesis;other biological processes"	"mitochondrion;nucleus"	"nucleic acid binding activity"	""	""	""	"CHCHD2P9"	"Q5T1J5"	""	""	"0"	"0"	"5.1"	"3.4"	"4.5"	"6.9"	"11.9"	"8.3"	"16.1"	"14.9"	"9.5"	"10.9"	"23.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9C0J8"	"pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2"	"2"	"2"	"4"	"2"	"1336"	"145.8"	"9.17"	"577.48"	"5.52"	"2"	"2"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	""	"Pf00400"	"55339"	"ENSG00000136709"	"WDR33"	"hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1"	""	"Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs"	"5"	"0"	"36.7"	"25.6"	"30.7"	"48.1"	"57.2"	"49.5"	"116.8"	"160.3"	"86.2"	"97.0"	"116.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBS4"	"DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1"	"7"	"2"	"4"	"2"	"358"	"40.5"	"6.18"	"711.46"	"5.51"	"2"	"2"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"non-structural extracellular;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00226, Pf01556"	"51726"	"ENSG00000090520"	"DNAJB11"	"hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4"	"Photodynamic therapy-induced unfolded protein response"	"XBP1(S) activates chaperone genes"	"2"	"0"	"112.9"	"87.2"	"125.6"	"187.3"	"207.1"	"183.3"	"215.6"	"244.8"	"136.3"	"191.7"	"282.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BPX5"	"Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1"	"18"	"1"	"1"	"1"	"153"	"16.9"	"6.60"	""	"5.49"	""	"1"	"cell organization and biogenesis;other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf04699"	"81873"	"ENSG00000136950"	"ARPC5L"	"hsa:81873; Q7Z523; Q9BPX5"	"Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling"	""	"2"	"0"	"6.5"	"3.5"	"8.1"	"11.2"	"13.3"	"10.5"	"26.3"	"24.5"	"15.3"	"22.9"	"32.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12849"	"G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3"	"6"	"2"	"3"	"2"	"480"	"53.1"	"6.19"	"382.47"	"5.49"	"1"	"2"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076"	"2926"	"ENSG00000132463"	"GRSF1"	"B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2"	"VEGFA-VEGFR2 signaling"	"Viral mRNA Translation"	"2"	"0"	"36.3"	"23.0"	"29.6"	"52.5"	"57.9"	"50.4"	"87.7"	"66.9"	"53.6"	"71.8"	"104.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L2E3"	"ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1"	"3"	"3"	"5"	"3"	"1194"	"133.9"	"8.78"	"935.64"	"5.49"	"3"	"2"	"cell organization and biogenesis;developmental processes"	"cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf04408, Pf07717"	"22907"	"ENSG00000132153"	"DHX30"	"A8K5F1; hsa:22907; O94965; Q7L2E3; Q7Z753; Q96CH4; Q9NUQ0"	""	""	"0"	"0"	"43.6"	"37.1"	"42.1"	"52.8"	"71.3"	"59.5"	"136.7"	"152.3"	"83.8"	"135.6"	"132.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NTK5"	"Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2"	"4"	"2"	"4"	"2"	"396"	"44.7"	"7.81"	"669.72"	"5.49"	"2"	"2"	"other metabolic processes"	"non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component"	"translation activity;other molecular function"	"Pf01926, Pf06071"	"29789"	"ENSG00000138430"	"OLA1"	"D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4"	""	"Platelet degranulation"	"1"	"0"	"102.8"	"72.6"	"103.9"	"148.0"	"197.1"	"187.1"	"348.7"	"352.9"	"213.3"	"278.4"	"485.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRZ9"	"Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1"	"3"	"2"	"2"	"2"	"838"	"97.0"	"7.93"	""	"5.48"	""	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00176, Pf00271"	"3070"	"ENSG00000119969"	"HELLS"	"B2RB41; hsa:3070; Q3LID1; Q6I7N7; Q76H76; Q76H77; Q76H78; Q76H79; Q76H80; Q76H81; Q7Z397; Q7Z5X2; Q8N6P4; Q9H4P5; Q9NRZ9"	"Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer"	""	"2"	"0"	"91.7"	"46.6"	"90.5"	"138.7"	"184.2"	"172.3"	"494.2"	"441.7"	"304.0"	"387.5"	"525.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92796"	"Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2"	"2"	"1"	"2"	"1"	"817"	"90.3"	"7.03"	"538.28"	"5.44"	"1"	"1"	"cell-cell signaling;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf00018, Pf00595, Pf00625, Pf10600"	"1741"	"ENSG00000082458"	"DLG3"	"B4E0H1; D3DVU5; hsa:1741; Q5JUW6; Q5JUW7; Q92796; Q9ULI8"	""	"RAF/MAP kinase cascade; Activation of Ca-permeable Kainate Receptor; Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; NrCAM interactions"	"10"	"0"	"7.0"	"3.1"	"9.6"	"9.9"	"11.7"	"12.9"	"23.8"	"31.3"	"24.0"	"23.5"	"41.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04637"	"Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4"	"6"	"3"	"4"	"3"	"393"	"43.6"	"6.79"	"597.76"	"5.43"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00870, Pf07710, Pf08563, Pf18521"	"7157"	"ENSG00000141510"	"TP53"	"hsa:7157; P04637; Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98; Q3LRW1; Q3LRW2; Q3LRW3; Q3LRW4; Q3LRW5; Q86UG1; Q8J016; Q99659; Q9BTM4; Q9HAQ8; Q9NP68; Q9NPJ2; Q9NZD0; Q9UBI2; Q9UQ61"	"AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Pleural mesothelioma; Lipid metabolism in senescent cells; DYRK1A involvement regarding cell proliferation in brain development; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma; 11p11.2 copy number variation syndrome ; A network map of Macrophage-stimulating protein (MSP) signaling; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)"	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-4 and Interleukin-13 signaling; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Factors involved in megakaryocyte development and platelet production; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; Regulation of NF-kappa B signaling; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional  activation of  cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability"	"107"	"0"	"121.9"	"88.0"	"114.8"	"156.1"	"212.4"	"197.4"	"398.8"	"381.5"	"237.2"	"321.2"	"354.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35998"	"26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3"	"8"	"3"	"6"	"3"	"433"	"48.6"	"5.95"	"1151.10"	"5.40"	"3"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"other molecular function"	"Pf00004, Pf17862"	"5701"	"ENSG00000161057"	"PSMC2"	"A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"64"	"0"	"6.9"	"5.1"	"5.3"	"6.3"	"8.1"	"7.0"	"17.1"	"15.8"	"13.3"	"17.2"	"20.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5V0"	"Zinc finger protein 706 OS=Homo sapiens OX=9606 GN=ZNF706 PE=1 SV=1"	"24"	"2"	"3"	"2"	"76"	"8.5"	"10.01"	"269.39"	"5.40"	"1"	"2"	"other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf04419, Pf12874"	"51123"	"ENSG00000120963"	"ZNF706"	"A8K362; hsa:51123; Q9Y5V0"	""	"Generic Transcription Pathway"	"1"	"0"	"134.9"	"75.3"	"127.9"	"131.4"	"157.2"	"125.5"	"666.7"	"681.5"	"525.3"	"717.0"	"1076.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NYU2"	"UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3"	"4"	"5"	"7"	"5"	"1555"	"177.1"	"5.63"	"1743.67"	"5.39"	"4"	"2"	"protein metabolism;other metabolic processes;stress response"	"ER/Golgi;other cell component"	"other molecular function"	"Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404"	"56886"	"ENSG00000136731"	"UGGT1"	"hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2"	"IL-18 signaling pathway"	"ER Quality Control Compartment (ERQC)"	"2"	"0"	"79.7"	"62.2"	"93.5"	"145.8"	"160.6"	"135.8"	"339.0"	"414.2"	"218.0"	"329.7"	"330.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14444"	"Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2"	"5"	"3"	"5"	"3"	"709"	"78.3"	"5.25"	"862.99"	"5.38"	"3"	"2"	"cell organization and biogenesis;other biological processes"	"cytosol;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf12287, Pf18293"	"4076"	"ENSG00000135387"	"CAPRIN1"	"A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09"	""	""	"0"	"0"	"26.2"	"20.3"	"26.6"	"44.4"	"47.2"	"41.1"	"86.6"	"79.2"	"42.0"	"71.9"	"78.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75347"	"Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3"	"19"	"2"	"4"	"2"	"108"	"12.8"	"5.29"	"698.37"	"5.37"	"2"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf02970"	"6902"	"ENSG00000171530"	"TBCA"	"B4DT30; hsa:6902; O75347"	"VEGFA-VEGFR2 signaling"	"Post-chaperonin tubulin folding pathway"	"2"	"0"	"75.4"	"56.2"	"63.9"	"86.9"	"105.8"	"104.2"	"197.9"	"182.6"	"98.0"	"160.9"	"277.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5JSZ5"	"Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2"	"2"	"2"	"3"	"2"	"2229"	"242.8"	"8.34"	"298.24"	"5.36"	"1"	"2"	"other biological processes"	""	""	"Pf07001"	"84726"	"ENSG00000288701"	"PRRC2B"	"hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683"	""	""	"0"	"0"	"12.8"	"10.7"	"14.1"	"17.4"	"17.0"	"17.4"	"36.2"	"43.7"	"24.6"	"34.6"	"39.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5J9"	"Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1"	"31"	"3"	"5"	"3"	"83"	"9.3"	"5.12"	"905.10"	"5.36"	"3"	"2"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf02953"	"26521"	"ENSG00000150779"	"TIMM8B"	"B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9"	""	"Mitochondrial protein import"	"1"	"0"	"164.4"	"94.8"	"170.2"	"211.2"	"265.5"	"213.5"	"1073.8"	"1097.6"	"659.9"	"820.5"	"1071.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62195"	"26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1"	"5"	"2"	"4"	"2"	"406"	"45.6"	"7.55"	"621.76"	"5.35"	"2"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00004, Pf16450, Pf17862"	"5705"	"ENSG00000087191"	"PSMC5"	"A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"65"	"0"	"46.6"	"36.1"	"49.2"	"67.9"	"87.5"	"80.8"	"152.5"	"139.5"	"82.2"	"112.9"	"150.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5A9"	"YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2"	"5"	"3"	"5"	"3"	"579"	"62.3"	"8.79"	"950.39"	"5.35"	"3"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity"	"Pf04146"	"51441"	"ENSG00000198492"	"YTHDF2"	"A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9"	""	""	"0"	"0"	"93.1"	"64.5"	"88.3"	"117.9"	"159.7"	"128.0"	"612.1"	"632.3"	"475.0"	"507.6"	"687.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96FJ2"	"Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1"	"8"	"1"	"4"	"1"	"89"	"10.3"	"7.37"	"575.51"	"5.34"	"1"	"1"	"other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf01221"	"140735"	"ENSG00000264364"	"DYNLL2"	"B2R5B4; hsa:140735; Q96FJ2"	"Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome"	"Separation of Sister Chromatids; Aggrephagy; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; Intraflagellar transport; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Macroautophagy; Activation of BMF and translocation to mitochondria"	"18"	"0"	"630.4"	"432.8"	"556.9"	"765.3"	"893.6"	"868.8"	"1207.2"	"1157.3"	"872.1"	"948.7"	"1381.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IVS2"	"Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2"	"6"	"2"	"3"	"2"	"390"	"42.9"	"8.72"	"345.63"	"5.31"	"1"	"2"	"other metabolic processes"	"mitochondrion"	"other molecular function"	"Pf00698"	"27349"	"ENSG00000100294"	"MCAT"	"B0QY72; hsa:27349; O95510; O95511; Q8IVS2"	"Mitochondrial fatty acid synthesis pathway"	"Mitochondrial Fatty Acid Beta-Oxidation"	"2"	"0"	"45.5"	"31.4"	"51.6"	"62.7"	"80.7"	"76.5"	"203.9"	"234.4"	"146.9"	"201.6"	"278.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35658"	"Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2"	"1"	"2"	"4"	"2"	"2090"	"213.5"	"7.47"	"741.09"	"5.31"	"2"	"2"	"cell cycle OR cell proliferation;other metabolic processes;transport;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf18617"	"8021"	"ENSG00000126883"	"NUP214"	"A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3"	""	"HCMV Early Events; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA"	"29"	"0"	"46.0"	"21.4"	"38.3"	"43.2"	"63.6"	"44.2"	"108.0"	"99.0"	"56.1"	"80.8"	"121.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZR1"	"Tropomodulin-2 OS=Homo sapiens OX=9606 GN=TMOD2 PE=1 SV=1"	"5"	"2"	"4"	"1"	"351"	"39.6"	"5.27"	"574.72"	"5.31"	"2"	"2"	"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf03250"	"29767"	"ENSG00000128872"	"TMOD2"	"B4DEW6; hsa:29767; Q9NZR1"	""	"Striated Muscle Contraction"	"1"	"0"	"50.3"	"33.4"	"51.5"	"51.2"	"72.1"	"62.7"	"85.7"	"73.2"	"57.0"	"70.1"	"160.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92665"	"28S ribosomal protein S31, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3"	"6"	"2"	"3"	"2"	"395"	"45.3"	"9.29"	"341.03"	"5.30"	"1"	"2"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	"other molecular function"	"Pf15433"	"10240"	"ENSG00000102738"	"MRPS31"	"B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"4.1"	"4.3"	"4.6"	"5.9"	"4.2"	"5.4"	"23.4"	"18.0"	"8.2"	"13.5"	"20.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13330"	"Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2"	"5"	"3"	"4"	"3"	"715"	"80.7"	"9.26"	"501.68"	"5.30"	"2"	"2"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00249, Pf00320, Pf01426, Pf01448, Pf17226"	"9112"	"ENSG00000182979"	"MTA1"	"A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8"	"Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; TAR syndrome"	"Potential therapeutics for SARS; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; SUMOylation of transcription factors"	"8"	"0"	"17.3"	"8.8"	"15.5"	"29.4"	"35.0"	"23.0"	"68.3"	"53.2"	"36.5"	"43.6"	"64.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46087"	"Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2"	"3"	"2"	"4"	"2"	"812"	"89.2"	"9.23"	"542.21"	"5.29"	"2"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf01189, Pf08062, Pf17125"	"4839"	"ENSG00000111641"	"NOP2"	"A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30"	"Imatinib and chronic myeloid leukemia"	"rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"	"3"	"0"	"34.9"	"19.0"	"31.7"	"33.9"	"52.2"	"49.1"	"212.7"	"211.7"	"191.2"	"202.5"	"285.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRP1"	"Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1"	"6"	"1"	"2"	"1"	"358"	"39.4"	"4.86"	"525.15"	"5.28"	"1"	"1"	"cell cycle OR cell proliferation;other biological processes"	"other cell component"	""	"Pf04194"	"84306"	"ENSG00000126249"	"PDCD2L"	"hsa:84306; Q9BRP1"	""	""	"0"	"0"	"13.6"	"9.1"	"16.9"	"26.8"	"32.7"	"25.9"	"58.8"	"73.0"	"37.8"	"44.4"	"44.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8ND56"	"Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3"	"6"	"2"	"3"	"2"	"463"	"50.5"	"9.52"	"339.64"	"5.25"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes"	"cytosol;cytoskeleton;other cell component"	"nucleic acid binding activity"	"Pf09532, Pf12701"	"26065"	"ENSG00000257103; ENSG00000262860"	"LSM14A"	"B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3"	""	""	"0"	"0"	"59.1"	"37.9"	"62.2"	"100.3"	"119.6"	"106.3"	"319.1"	"360.4"	"200.1"	"258.2"	"312.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06737"	"Glycogen phosphorylase, liver form OS=Homo sapiens OX=9606 GN=PYGL PE=1 SV=4"	"2"	"2"	"4"	"2"	"847"	"97.1"	"7.17"	"657.52"	"5.21"	"2"	"2"	"other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;other cell component"	"other molecular function"	"Pf00343"	"5836"	"ENSG00000100504"	"PYGL"	"A6NDQ4; B4DUB7; F5H816; hsa:5836; O60567; O60752; O60913; P06737; Q501V9; Q641R5; Q96G82"	"TNF-alpha signaling pathway; Glycogen synthesis and degradation; Disorders of galactose metabolism"	"Neutrophil degranulation; Glycogen breakdown (glycogenolysis)"	"5"	"0"	"41.1"	"25.3"	"33.9"	"55.3"	"56.9"	"77.1"	"101.5"	"94.3"	"73.7"	"98.2"	"159.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60783"	"28S ribosomal protein S14, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1"	"12"	"1"	"2"	"1"	"128"	"15.1"	"11.41"	"438.11"	"5.19"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	"other molecular function"	"Pf00253"	"63931"	"ENSG00000120333"	"MRPS14"	"hsa:63931; O60783; Q5R358"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"14.0"	"11.1"	"18.2"	"24.7"	"31.5"	"26.8"	"50.5"	"63.0"	"35.1"	"37.3"	"58.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07339"	"Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1"	"2"	"1"	"4"	"1"	"412"	"44.5"	"6.54"	"819.37"	"5.18"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"other membranes;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00026, Pf07966"	"1509"	"ENSG00000117984"	"CTSD"	"hsa:1509; P07339; Q6IB57"	"Prolactin signaling pathway; 8p23.1 copy number variation syndrome"	"MHC class II antigen presentation; Collagen degradation; Neutrophil degranulation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins"	"8"	"0"	"56.0"	"30.6"	"45.7"	"73.5"	"87.6"	"76.8"	"122.1"	"148.4"	"76.9"	"110.3"	"160.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UMR2"	"ATP-dependent RNA helicase DDX19B OS=Homo sapiens OX=9606 GN=DDX19B PE=1 SV=1"	"5"	"2"	"4"	"2"	"479"	"53.9"	"6.30"	"634.23"	"5.17"	"2"	"2"	"other metabolic processes;transport"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271"	"11269"	"ENSG00000157349"	"DDX19B"	"B3KNE9; B4DXS6; E7EMK4; hsa:11269; Q6FIB7; Q6IAE0; Q96KE7; Q9H0U0; Q9UMR2"	""	""	"0"	"0"	"34.3"	"22.2"	"34.6"	"43.0"	"61.3"	"49.4"	"212.3"	"221.1"	"149.1"	"173.7"	"191.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96FF9"	"Sororin OS=Homo sapiens OX=9606 GN=CDCA5 PE=1 SV=1"	"9"	"2"	"4"	"2"	"252"	"27.6"	"9.61"	"575.54"	"5.17"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf09666"	"113130"	"ENSG00000146670"	"CDCA5"	"A8K625; hsa:113130; Q96FF9"	""	"Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Establishment of Sister Chromatid Cohesion"	"3"	"0"	"41.7"	"27.6"	"36.4"	"59.6"	"79.1"	"66.8"	"262.5"	"256.9"	"150.7"	"199.5"	"241.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P00338"	"L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2"	"6"	"2"	"5"	"2"	"332"	"36.7"	"8.27"	"932.56"	"5.16"	"2"	"2"	"other metabolic processes"	"cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00056, Pf02866"	"3939"	"ENSG00000134333; ENSG00000288299"	"LDHA"	"B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9"	"Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; A network map of Macrophage-stimulating protein (MSP) signaling; Metabolic Epileptic Disorders"	"Pyruvate metabolism"	"19"	"0"	"160.5"	"159.1"	"182.2"	"194.4"	"250.3"	"296.4"	"431.0"	"361.9"	"231.9"	"360.5"	"693.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35269"	"General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2"	"6"	"3"	"5"	"3"	"517"	"58.2"	"7.49"	"1172.23"	"5.16"	"3"	"2"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf05793"	"2962"	"ENSG00000125651"	"GTF2F1"	"B2RCS0; hsa:2962; P35269; Q9BWN0"	""	"Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM"	"32"	"0"	"14.8"	"14.3"	"18.2"	"23.9"	"26.1"	"25.1"	"129.1"	"135.7"	"158.5"	"215.7"	"211.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86VN1"	"Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1"	"5"	"2"	"4"	"2"	"386"	"43.8"	"7.20"	"737.53"	"5.14"	"2"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport"	"other membranes;cytosol;nucleus;other cytoplasmic organelle"	"other molecular function"	"Pf04157, Pf11605"	"51028"	"ENSG00000136100"	"VPS36"	"A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3"	"Network map of SARS-CoV-2 signaling pathway"	"Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events"	"3"	"0"	"31.0"	"15.7"	"37.0"	"45.6"	"52.1"	"44.5"	"121.2"	"178.8"	"167.1"	"280.7"	"604.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5T200"	"Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1"	"1"	"2"	"4"	"2"	"1668"	"196.5"	"9.42"	"568.75"	"5.12"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00642"	"23091"	"ENSG00000123200"	"ZC3H13"	"A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6"	""	""	"0"	"0"	"71.7"	"33.4"	"62.4"	"90.5"	"107.0"	"93.8"	"331.8"	"310.0"	"187.6"	"270.8"	"317.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28288"	"ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1"	"3"	"2"	"3"	"2"	"659"	"75.4"	"9.36"	"342.14"	"5.11"	"1"	"2"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"cytosol;mitochondrion;other cytoplasmic organelle;other cell component"	"transporter activity;other molecular function"	"Pf00005, Pf06472"	"5825"	"ENSG00000117528"	"ABCD3"	"D3DT46; hsa:5825; P28288; Q15271; Q6NUN5; Q96DA3; Q9H529"	"Nuclear receptors in lipid metabolism and toxicity; Fragile X syndrome"	"RHOA GTPase cycle; RHOC GTPase cycle; Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis"	"6"	"0"	"62.1"	"49.8"	"57.5"	"83.8"	"114.5"	"93.5"	"169.9"	"162.9"	"112.9"	"163.5"	"221.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P56545"	"C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1"	"5"	"3"	"5"	"1"	"445"	"48.9"	"6.95"	"880.35"	"5.11"	"3"	"2"	"cell-cell signaling;cell organization and biogenesis;transport;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00389, Pf02826"	"1488"	"ENSG00000175029"	"CTBP2"	"A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8"	"Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma"	"Repression of WNT target genes; Signaling by TCF7L2 mutants"	"11"	"0"	"86.3"	"73.3"	"102.7"	"169.9"	"178.8"	"128.9"	"287.4"	"284.0"	"155.5"	"171.7"	"160.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5B9"	"FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1"	"3"	"3"	"5"	"3"	"1047"	"119.8"	"5.66"	"782.28"	"5.11"	"3"	"2"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus"	"other molecular function"	"Pf00557, Pf08512, Pf08644, Pf14826"	"11198"	"ENSG00000092201"	"SUPT16H"	"hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9"	""	"TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events"	"12"	"0"	"135.5"	"70.8"	"113.7"	"155.9"	"184.3"	"160.1"	"450.3"	"464.7"	"280.9"	"410.2"	"556.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P43250"	"G protein-coupled receptor kinase 6 OS=Homo sapiens OX=9606 GN=GRK6 PE=1 SV=2"	"4"	"2"	"4"	"2"	"576"	"65.9"	"8.00"	"602.12"	"5.04"	"2"	"2"	"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;other cell component"	"kinase activity;other molecular function"	"Pf00069, Pf00615"	"2870"	"ENSG00000198055"	"GRK6"	"hsa:2870; O60541; P43250; Q13652"	"Follicle stimulating hormone (FSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Calcium regulation in cardiac cells; 5q35 copy number variation"	"G alpha (s) signalling events"	"7"	"0"	"10.4"	"6.6"	"15.3"	"18.0"	"24.5"	"21.2"	"62.7"	"72.5"	"59.2"	"90.8"	"113.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P015"	"39S ribosomal protein L15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1"	"7"	"2"	"4"	"2"	"296"	"33.4"	"10.01"	"595.32"	"5.04"	"2"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf00828"	"29088"	"ENSG00000137547"	"MRPL15"	"hsa:29088; Q96Q54; Q9H0Y1; Q9P015"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"63.3"	"52.8"	"70.2"	"100.1"	"138.3"	"100.4"	"225.5"	"239.4"	"152.1"	"216.8"	"293.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75179"	"Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3"	"0"	"1"	"4"	"1"	"2603"	"274.1"	"6.52"	"591.08"	"5.03"	"1"	"1"	"stress response;developmental processes;other biological processes"	"other membranes;nucleus;other cell component"	"other molecular function"	"Pf00013, Pf12796"	"26057"	"ENSG00000132466"	"ANKRD17"	"E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9"	""	""	"0"	"0"	"4.3"	"6.0"	"7.8"	"10.4"	"13.4"	"11.5"	"22.0"	"22.5"	"12.8"	"17.0"	"21.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BQA1"	"Methylosome protein 50 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1"	"6"	"2"	"3"	"2"	"342"	"36.7"	"5.17"	"238.47"	"5.00"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00400"	"79084"	"ENSG00000116455"	"WDR77"	"B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3"	""	"snRNP Assembly; RMTs methylate histone arginines"	"2"	"0"	"14.4"	"11.3"	"14.1"	"17.5"	"26.4"	"24.2"	"41.8"	"47.6"	"26.8"	"34.4"	"49.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P37837"	"Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2"	"6"	"2"	"4"	"2"	"337"	"37.5"	"6.81"	"557.05"	"4.98"	"2"	"2"	"other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf00923"	"6888"	"ENSG00000177156"	"TALDO1"	"B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45"	"Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer"	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P"	"9"	"0"	"69.6"	"55.5"	"61.2"	"68.6"	"110.1"	"113.7"	"166.3"	"148.1"	"109.0"	"160.2"	"304.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96T58"	"Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1"	"1"	"3"	"5"	"2"	"3664"	"402.0"	"7.64"	"987.35"	"4.97"	"3"	"2"	"signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf07744"	"23013"	"ENSG00000065526"	"SPEN"	"hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556"	"Notch signaling pathway"	"RHOBTB1 GTPase cycle"	"2"	"0"	"39.2"	"26.0"	"38.8"	"50.1"	"60.5"	"54.5"	"135.0"	"122.1"	"72.9"	"104.4"	"120.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NR33"	"DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2"	"18"	"2"	"2"	"2"	"117"	"12.2"	"4.92"	""	"4.96"	""	"2"	"DNA metabolism;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00808"	"56655"	"ENSG00000115350"	"POLE4"	"hsa:56655; Q53TR2; Q9NR33"	"Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair"	"Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER"	"16"	"0"	"6.7"	"6.1"	"6.3"	"6.8"	"12.5"	"8.8"	"17.6"	"19.0"	"17.2"	"16.0"	"29.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14204"	"Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5"	"0"	"2"	"4"	"2"	"4646"	"532.1"	"6.40"	"631.16"	"4.92"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199"	"1778"	"ENSG00000197102"	"DYNC1H1"	"B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5"	"Ciliary landscape; Intraflagellar transport proteins binding to dynein; PAFAH1B1 copy number variation"	"Separation of Sister Chromatids; Neutrophil degranulation; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; HCMV Early Events; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"23"	"0"	"18.6"	"12.1"	"13.7"	"20.9"	"24.3"	"24.2"	"38.8"	"34.4"	"21.4"	"38.5"	"46.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H977"	"WD repeat-containing protein 54 OS=Homo sapiens OX=9606 GN=WDR54 PE=1 SV=1"	"4"	"1"	"2"	"1"	"334"	"35.9"	"6.20"	""	"4.92"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytoskeleton;other cell component"	"other molecular function"	""	"84058"	"ENSG00000005448"	"WDR54"	"B9A049; D6W5I3; hsa:84058; Q53H85; Q86V45; Q9H977"	""	""	"0"	"0"	"59.8"	"12.4"	"49.3"	"83.5"	"119.6"	"91.0"	"629.5"	"583.1"	"72.0"	"146.4"	"462.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WVM7"	"Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3"	"1"	"2"	"3"	"2"	"1258"	"144.3"	"5.59"	"277.88"	"4.92"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf08514"	"10274"	"ENSG00000118007"	"STAG1"	"hsa:10274; O00539; Q6P275; Q8WVM7"	"Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation"	"Separation of Sister Chromatids; Estrogen-dependent gene expression; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin"	"10"	"0"	"69.9"	"37.0"	"59.2"	"70.2"	"99.7"	"80.7"	"230.9"	"207.3"	"110.4"	"181.4"	"222.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92733"	"Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1"	"7"	"4"	"6"	"4"	"491"	"52.4"	"5.10"	"1087.84"	"4.91"	"4"	"2"	"cell cycle OR cell proliferation;other biological processes"	"nucleus"	""	"Pf10253"	"5546"	"ENSG00000143294"	"PRCC"	"A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733"	"Type 2 papillary renal cell carcinoma; IL-18 signaling pathway"	"mRNA Splicing - Major Pathway"	"3"	"0"	"98.9"	"63.5"	"109.7"	"154.3"	"203.0"	"174.5"	"605.9"	"601.1"	"380.7"	"499.8"	"632.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31151"	"Protein S100-A7 OS=Homo sapiens OX=9606 GN=S100A7 PE=1 SV=4"	"35"	"3"	"5"	"3"	"101"	"11.5"	"6.77"	"1276.56"	"4.90"	"3"	"2"	"stress response;developmental processes;other biological processes"	"non-structural extracellular;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf01023"	"6278"	"ENSG00000143556"	"S100A7"	"hsa:6278; P31151; Q5SY67; Q6FGE3; Q9H1E2"	""	"Neutrophil degranulation; Metal sequestration by antimicrobial proteins"	"2"	"0"	"28.4"	"17.0"	"34.3"	"44.6"	"48.5"	"48.0"	"162.7"	"226.2"	"143.8"	"162.7"	"140.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61927"	"60S ribosomal protein L37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2"	"13"	"2"	"3"	"2"	"97"	"11.1"	"11.74"	"281.15"	"4.88"	"1"	"2"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf01907"	"6167"	"ENSG00000145592"	"RPL37"	"B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"185.5"	"124.6"	"176.2"	"208.4"	"256.7"	"231.2"	"1120.6"	"955.9"	"790.6"	"922.8"	"967.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H814"	"Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1"	"3"	"2"	"4"	"2"	"394"	"44.4"	"5.40"	"533.90"	"4.85"	"2"	"2"	"transport;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf10258"	"51808"	"ENSG00000164902"	"PHAX"	"hsa:51808; Q9H814; Q9H8W1"	""	"RNA polymerase II transcribes snRNA genes; snRNP Assembly"	"2"	"0"	"5.6"	"6.2"	"6.5"	"9.3"	"8.8"	"10.6"	"18.2"	"14.6"	"10.3"	"10.7"	"19.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WW12"	"PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2"	"10"	"2"	"4"	"2"	"178"	"18.9"	"7.49"	"578.21"	"4.84"	"2"	"2"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes"	"nucleus"	""	"Pf15473"	"57092"	"ENSG00000081154"	"PCNP"	"B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81"	""	""	"0"	"0"	"48.0"	"30.7"	"40.2"	"58.6"	"63.4"	"62.1"	"174.6"	"166.1"	"120.2"	"151.5"	"232.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P42765"	"3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2"	"4"	"2"	"4"	"2"	"397"	"41.9"	"8.09"	"565.06"	"4.83"	"2"	"2"	"cell organization and biogenesis;other metabolic processes;stress response;transport"	"mitochondrion"	"other molecular function"	"Pf00108, Pf02803"	"10449"	"ENSG00000167315"	"ACAA2"	"hsa:10449; P42765; Q9BUT6"	"Fatty acid biosynthesis"	"Mitochondrial Fatty Acid Beta-Oxidation"	"2"	"0"	"68.4"	"49.1"	"75.3"	"113.6"	"113.5"	"98.5"	"292.9"	"313.6"	"189.0"	"345.0"	"774.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04843"	"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1"	"4"	"2"	"3"	"2"	"607"	"68.5"	"6.38"	"377.76"	"4.83"	"1"	"2"	"protein metabolism;other metabolic processes"	"other membranes;cytosol;ER/Golgi;other cell component"	""	"Pf04597"	"6184"	"ENSG00000163902"	"RPN1"	"B2R5Z0; D3DNB6; hsa:6184; P04843; Q68DT1"	"Proteasome degradation; N-glycan biosynthesis"	"SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein"	"5"	"0"	"39.9"	"30.4"	"26.9"	"40.6"	"55.7"	"47.3"	"96.6"	"85.7"	"63.0"	"81.5"	"102.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P29372"	"DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3"	"8"	"2"	"4"	"2"	"298"	"32.8"	"9.57"	"570.91"	"4.80"	"2"	"2"	"DNA metabolism;other metabolic processes;stress response"	"cytosol;mitochondrion;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf02245"	"4350"	"ENSG00000103152"	"MPG"	"G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5"	"Base excision repair; DNA repair pathways, full network"	"Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1"	"5"	"0"	"48.6"	"35.0"	"62.5"	"83.3"	"108.3"	"80.7"	"466.3"	"462.8"	"235.8"	"285.3"	"363.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NPD3"	"Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3"	"7"	"1"	"2"	"1"	"245"	"26.4"	"6.52"	"397.40"	"4.79"	"1"	"1"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01138, Pf03725"	"54512"	"ENSG00000178896"	"EXOSC4"	"hsa:54512; Q9NPD3"	"Ciliary landscape"	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"7"	"0"	"21.7"	"19.1"	"28.9"	"33.8"	"51.8"	"37.5"	"74.9"	"86.8"	"87.0"	"73.2"	"70.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9ULX6"	"A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4"	"6"	"3"	"6"	"3"	"646"	"71.6"	"5.05"	"1163.11"	"4.78"	"3"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04988"	"26993"	"ENSG00000011243"	"AKAP8L"	"B4DJ74; B5BU90; hsa:26993; O94792; Q96J58; Q9NRQ0; Q9UGM0; Q9ULX6"	""	"Formation of WDR5-containing histone-modifying complexes"	"1"	"0"	"21.4"	"16.5"	"19.1"	"27.3"	"29.1"	"31.0"	"57.5"	"50.7"	"31.5"	"52.5"	"60.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q969S3"	"Zinc finger protein 622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1"	"5"	"2"	"3"	"2"	"477"	"54.2"	"6.15"	"268.27"	"4.77"	"1"	"2"	"signal transduction;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf12171, Pf12756"	"90441"	"ENSG00000173545"	"ZNF622"	"hsa:90441; Q969S3"	""	""	"0"	"0"	"2.3"	"0.0"	"2.3"	"0.0"	"4.1"	"4.8"	"25.4"	"22.1"	"21.9"	"17.2"	"20.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43678"	"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3"	"21"	"1"	"1"	"1"	"99"	"10.9"	"9.57"	""	"4.76"	""	"1"	"cell organization and biogenesis;other metabolic processes;transport;developmental processes"	"other membranes;mitochondrion"	"transporter activity"	"Pf05047"	"4695"	"ENSG00000131495"	"NDUFA2"	"D6RJD6; hsa:4695; O43678; Q6IAY8"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"5"	"0"	"7.1"	"6.9"	"8.6"	"10.3"	"10.0"	"9.2"	"22.8"	"50.6"	"13.2"	"22.1"	"21.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRY2"	"SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1"	"9"	"1"	"3"	"1"	"104"	"11.4"	"9.25"	"373.25"	"4.75"	"1"	"1"	"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	""	"Pf15925"	"58493"	"ENSG00000148153"	"INIP"	"hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43715"	"TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1"	"18"	"1"	"2"	"1"	"76"	"8.8"	"5.48"	"599.87"	"4.73"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes"	"mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf05254"	"51499"	"ENSG00000170855"	"TRIAP1"	"B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7"	"5q35 copy number variation"	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"	"2"	"0"	"30.0"	"25.8"	"33.3"	"50.2"	"65.8"	"63.0"	"130.2"	"121.5"	"96.0"	"118.9"	"123.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99547"	"M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2"	"9"	"2"	"4"	"2"	"160"	"19.0"	"5.20"	"600.16"	"4.73"	"2"	"2"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf10175"	"10200"	"ENSG00000135698"	"MPHOSPH6"	"B2RAF0; hsa:10200; Q99547"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"95.9"	"48.5"	"89.6"	"116.0"	"156.3"	"122.5"	"382.4"	"335.6"	"213.8"	"260.2"	"358.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96MU7"	"YTH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=YTHDC1 PE=1 SV=3"	"2"	"2"	"4"	"2"	"727"	"84.6"	"6.23"	"587.51"	"4.73"	"2"	"2"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;nucleus"	"nucleic acid binding activity"	"Pf04146"	"91746"	"ENSG00000083896; ENSG00000275272"	"YTHDC1"	"hsa:91746; Q4W5Q3; Q7Z622; Q8TF35; Q96MU7"	""	""	"0"	"0"	"144.7"	"106.9"	"162.3"	"189.3"	"250.1"	"223.0"	"462.4"	"414.9"	"305.8"	"432.9"	"490.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46940"	"Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1"	"1"	"2"	"3"	"2"	"1657"	"189.1"	"6.48"	"288.26"	"4.71"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00307, Pf00612, Pf00616, Pf03836"	"8826"	"ENSG00000140575"	"IQGAP1"	"A7MBM3; hsa:8826; P46940"	"VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway"	"Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants"	"25"	"0"	"23.0"	"15.4"	"18.6"	"26.3"	"40.4"	"32.6"	"85.9"	"84.3"	"53.8"	"74.8"	"101.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UNP9"	"Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1"	"8"	"3"	"4"	"2"	"301"	"33.4"	"5.60"	"751.70"	"4.71"	"2"	"2"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf00160"	"10450"	"ENSG00000084072"	"PPIE"	"B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9"	""	"mRNA Splicing - Major Pathway; Neutrophil degranulation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER"	"6"	"0"	"82.0"	"60.6"	"77.1"	"104.8"	"137.5"	"110.0"	"317.6"	"258.4"	"160.0"	"264.5"	"292.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H9F9"	"Actin-related protein 5 OS=Homo sapiens OX=9606 GN=ACTR5 PE=1 SV=2"	"3"	"1"	"2"	"1"	"607"	"68.3"	"5.27"	"337.03"	"4.70"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	""	"Pf00022"	"79913"	"ENSG00000101442"	"ACTR5"	"hsa:79913; Q86WF7; Q8IUY5; Q8N724; Q9BRN0; Q9BVB7; Q9H9F9"	""	"UCH proteinases; DNA Damage Recognition in GG-NER"	"2"	"0"	"13.8"	"10.0"	"18.2"	"28.1"	"24.9"	"21.7"	"55.3"	"59.5"	"39.6"	"43.3"	"57.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96BZ8"	"Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=1"	"6"	"1"	"2"	"1"	"264"	"30.5"	"9.69"	"450.90"	"4.68"	"1"	"1"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13405"	"39S ribosomal protein L49, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1"	"11"	"2"	"3"	"2"	"166"	"19.2"	"9.45"	"351.10"	"4.68"	"1"	"2"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf05046"	"740"	"ENSG00000149792"	"MRPL49"	"B2R4G6; hsa:740; Q13405"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"59.2"	"39.9"	"59.9"	"77.9"	"107.5"	"99.4"	"207.0"	"228.4"	"145.2"	"202.9"	"307.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P21579"	"Synaptotagmin-1 OS=Homo sapiens OX=9606 GN=SYT1 PE=1 SV=1"	"4"	"2"	"3"	"2"	"422"	"47.5"	"8.12"	"257.77"	"4.67"	"1"	"2"	"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00168"	"6857"	"ENSG00000067715"	"SYT1"	"hsa:6857; P21579; Q6AI31"	"Synaptic vesicle pathway"	"Cargo recognition for clathrin-mediated endocytosis; Glutamate Neurotransmitter Release Cycle; Neurexins and neuroligins; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type G (botG)"	"12"	"0"	"30.3"	"20.3"	"29.0"	"35.0"	"47.6"	"49.5"	"106.4"	"159.3"	"134.6"	"191.4"	"248.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13425"	"Beta-2-syntrophin OS=Homo sapiens OX=9606 GN=SNTB2 PE=1 SV=1"	"2"	"1"	"4"	"1"	"540"	"57.9"	"8.82"	"697.71"	"4.66"	"1"	"1"	""	"plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00595, Pf18012"	"6645"	"ENSG00000168807"	"SNTB2"	"hsa:6645; Q13425; Q9BY09"	""	""	"0"	"0"	"49.8"	"49.3"	"53.2"	"71.0"	"82.7"	"76.3"	"191.9"	"176.3"	"109.9"	"143.5"	"135.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11413"	"Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4"	"8"	"3"	"5"	"3"	"515"	"59.2"	"6.84"	"869.46"	"4.65"	"3"	"2"	"other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00479, Pf02781"	"2539"	"ENSG00000160211"	"G6PD"	"D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2"	"Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction"	"TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway"	"16"	"0"	"15.8"	"12.6"	"21.2"	"29.1"	"29.3"	"33.3"	"61.9"	"72.0"	"53.4"	"64.3"	"80.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07311"	"Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2"	"17"	"2"	"3"	"2"	"99"	"11.3"	"9.31"	"248.24"	"4.63"	"1"	"2"	"other metabolic processes"	""	"other molecular function"	"Pf00708"	"97"	"ENSG00000119640"	"ACYP1"	"A6NDV8; B2R590; hsa:97; P07311"	""	""	"0"	"0"	"146.3"	"106.4"	"144.4"	"127.0"	"145.8"	"142.2"	"240.4"	"248.6"	"167.8"	"209.0"	"427.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23919"	"Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4"	"11"	"3"	"5"	"3"	"212"	"23.8"	"8.27"	"916.57"	"4.63"	"3"	"2"	"other metabolic processes;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf02223"	"1841"	"ENSG00000168393"	"DTYMK"	"B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4"	"Pyrimidine metabolism; 2q37 copy number variation syndrome"	"Interconversion of nucleotide di- and triphosphates"	"3"	"0"	"5.2"	"4.2"	"6.7"	"8.0"	"9.2"	"11.4"	"35.2"	"38.7"	"26.4"	"30.3"	"51.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94826"	"Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1"	"5"	"4"	"6"	"4"	"608"	"67.4"	"7.12"	"1085.74"	"4.60"	"4"	"2"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf00515, Pf13181"	"9868"	"ENSG00000154174"	"TOMM70"	"D3DN48; hsa:9868; O94826"	"Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction"	"Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy"	"9"	"0"	"239.5"	"156.4"	"256.9"	"393.7"	"455.4"	"372.4"	"1033.6"	"996.0"	"669.2"	"788.4"	"1007.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86TS9"	"39S ribosomal protein L52, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL52 PE=1 SV=2"	"15"	"1"	"2"	"1"	"123"	"13.7"	"10.26"	"455.88"	"4.60"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	"other molecular function"	"Pf18699"	"122704"	"ENSG00000172590"	"MRPL52"	"A6NMQ8; A8MXK5; A8MYI6; G3XCN9; hsa:122704; Q6NVH8; Q86TS9"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"14.6"	"9.8"	"14.4"	"22.1"	"34.5"	"28.0"	"56.5"	"57.0"	"30.7"	"47.6"	"70.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2Q9"	"28S ribosomal protein S28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1"	"11"	"2"	"4"	"2"	"187"	"20.8"	"9.10"	"492.50"	"4.57"	"2"	"2"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	""	"Pf10246"	"28957"	"ENSG00000147586"	"MRPS28"	"B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"60.0"	"43.3"	"52.7"	"76.3"	"109.4"	"84.7"	"178.2"	"188.7"	"105.7"	"150.0"	"174.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NR28"	"Diablo homolog, mitochondrial OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1"	"8"	"1"	"2"	"1"	"239"	"27.1"	"5.90"	"577.22"	"4.57"	"1"	"1"	"signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion"	""	"Pf09057"	"56616"	"ENSG00000184047"	"DIABLO"	"B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28"	"Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity"	"SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria"	"10"	"0"	"17.3"	"11.2"	"13.4"	"22.5"	"21.6"	"20.7"	"27.3"	"31.5"	"14.3"	"17.9"	"23.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35226"	"Polycomb complex protein BMI-1 OS=Homo sapiens OX=9606 GN=BMI1 PE=1 SV=2"	"5"	"2"	"4"	"2"	"326"	"36.9"	"8.63"	"575.74"	"4.56"	"2"	"2"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf13923, Pf16207"	"100532731; 648"	"ENSG00000168283"	"BMI1"	"hsa:100532731; hsa:648; P35226; Q16030; Q5T8Z3; Q96F37"	"Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; CCL18 signaling pathway"	"SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6"	"12"	"0"	"71.4"	"28.3"	"59.6"	"93.0"	"107.1"	"100.9"	"243.6"	"236.6"	"108.1"	"149.7"	"223.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HCC0"	"Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1"	"8"	"4"	"5"	"4"	"563"	"61.3"	"7.68"	"1103.70"	"4.55"	"3"	"2"	"other metabolic processes"	"cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf01039"	"64087"	"ENSG00000131844"	"MCCC2"	"A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7"	""	"Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency"	"3"	"0"	"153.3"	"149.6"	"188.6"	"171.4"	"200.9"	"203.5"	"401.1"	"418.6"	"333.2"	"441.6"	"610.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75717"	"WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1"	"1"	"1"	"2"	"1"	"1129"	"125.9"	"5.62"	"459.65"	"4.55"	"1"	"1"	"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00400, Pf12341, Pf12894"	"11169"	"ENSG00000198554"	"WDHD1"	"C9JW18; F6W0U7; hsa:11169; O75717"	"Mesodermal commitment pathway"	""	"1"	"0"	"6.0"	"3.1"	"6.4"	"8.4"	"7.8"	"8.2"	"20.3"	"24.1"	"8.9"	"19.8"	"33.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92974"	"Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4"	"1"	"1"	"2"	"1"	"986"	"111.5"	"7.27"	"563.50"	"4.53"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component"	"enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00621, Pf17838"	"9181"	"ENSG00000116584"	"ARHGEF2"	"D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023"	"Pathogenic Escherichia coli infection"	"G alpha (12/13) signalling events; RHOA GTPase cycle; NRAGE signals death through JNK; RHOB GTPase cycle"	"5"	"0"	"20.8"	"16.2"	"16.9"	"24.9"	"36.4"	"21.6"	"88.2"	"96.9"	"70.4"	"85.5"	"88.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9ULR0"	"Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3"	"7"	"1"	"2"	"1"	"285"	"33.0"	"5.17"	"499.78"	"4.53"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	""	"Pf06246"	"100534599; 57461"	"ENSG00000240682"	"ISY1"	"hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0"	""	"Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway"	"5"	"0"	"3.0"	"2.3"	"7.0"	"5.7"	"3.5"	"10.7"	"16.3"	"17.4"	"16.8"	"10.6"	"18.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVM6"	"DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1"	"6"	"1"	"2"	"1"	"304"	"34.7"	"8.53"	"521.34"	"4.53"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf00226"	"55192"	"ENSG00000104129"	"DNAJC17"	"hsa:55192; Q9NVM6"	""	""	"0"	"0"	"4.9"	"3.3"	"4.0"	"1.8"	"6.0"	"6.1"	"28.3"	"26.1"	"24.7"	"34.3"	"60.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43663"	"Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2"	"4"	"3"	"5"	"1"	"620"	"71.6"	"6.68"	"876.93"	"4.51"	"3"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf03999"	"9055"	"ENSG00000198901"	"PRC1"	"A6NC44; B4DLR1; H9KV59; hsa:9055; O43663; Q9BSB6"	""	"RHO GTPases activate CIT"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6DKJ4"	"Nucleoredoxin OS=Homo sapiens OX=9606 GN=NXN PE=1 SV=2"	"4"	"1"	"2"	"1"	"435"	"48.4"	"4.97"	"466.68"	"4.49"	"1"	"1"	"cell-cell signaling;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf13848, Pf13905"	"64359"	"ENSG00000167693"	"NXN"	"B4DXQ0; D3DTH2; hsa:64359; Q3SWW6; Q6DKJ4; Q6P3U6; Q7L4C6; Q9H9Q1"	""	""	"0"	"0"	"31.6"	"13.5"	"37.1"	"48.5"	"52.4"	"61.6"	"75.4"	"84.0"	"55.7"	"72.6"	"101.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52701"	"DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2"	"2"	"3"	"5"	"3"	"1360"	"152.7"	"6.90"	"763.24"	"4.48"	"3"	"2"	"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192"	"2956"	"ENSG00000116062"	"MSH6"	"B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5"	"Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair"	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6"	"8"	"0"	"68.7"	"45.9"	"64.2"	"97.3"	"113.3"	"96.2"	"264.0"	"240.7"	"158.2"	"218.7"	"257.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O96013"	"Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1"	"4"	"1"	"1"	"1"	"591"	"64.0"	"9.73"	""	"4.46"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;ER/Golgi;other cell component"	"kinase activity;other molecular function"	"Pf00069, Pf00786"	"10298"	"ENSG00000130669"	"PAK4"	"B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8"	"Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway"	"CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle"	"24"	"0"	"16.6"	"10.4"	"13.2"	"14.2"	"24.1"	"20.2"	"46.1"	"53.2"	"40.7"	"44.6"	"53.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05198"	"Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3"	"5"	"2"	"3"	"2"	"315"	"36.1"	"5.08"	"303.59"	"4.46"	"1"	"2"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"translation activity;nucleic acid binding activity"	"Pf00575, Pf07541"	"1965"	"ENSG00000134001"	"EIF2S1"	"hsa:1965; P05198"	"Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency"	"19"	"0"	"45.2"	"30.7"	"53.1"	"59.3"	"83.4"	"63.5"	"243.9"	"239.2"	"172.0"	"279.1"	"565.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75718"	"Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1"	"4"	"2"	"3"	"2"	"401"	"46.5"	"5.73"	"243.42"	"4.45"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;ER/Golgi;other cell component"	""	""	"10491"	"ENSG00000170275"	"CRTAP"	"B2RBL6; hsa:10491; O75718"	"Type I collagen synthesis in the context of osteogenesis imperfecta"	"Collagen biosynthesis and modifying enzymes"	"2"	"0"	"38.0"	"27.3"	"44.0"	"62.5"	"69.6"	"62.1"	"173.4"	"167.1"	"118.9"	"181.5"	"243.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NAV1"	"Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1"	"4"	"1"	"2"	"1"	"312"	"37.5"	"9.96"	"537.54"	"4.45"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf03371, Pf12871"	"84950"	"ENSG00000134748"	"PRPF38A"	"hsa:84950; Q8NAV1; Q96JW1; Q9BVZ8"	"MECP2 and associated Rett syndrome"	"mRNA Splicing - Major Pathway"	"2"	"0"	"8.7"	"4.8"	"10.3"	"10.3"	"6.9"	"12.3"	"28.8"	"35.1"	"18.1"	"23.4"	"42.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60953"	"Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2"	"6"	"1"	"2"	"1"	"191"	"21.2"	"6.55"	"547.79"	"4.44"	"1"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00071"	"998"	"ENSG00000070831"	"CDC42"	"hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2"	"Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)"	"RHO GTPases activate IQGAPs; RHOG GTPase cycle; MAPK6/MAPK4 signaling; EGFR downregulation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHOU GTPase cycle; DCC mediated attractive signaling; GPVI-mediated activation cascade; Myogenesis; G beta:gamma signalling through CDC42; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1"	"61"	"0"	"147.1"	"71.8"	"101.4"	"157.1"	"182.1"	"158.8"	"300.7"	"302.7"	"173.8"	"251.5"	"467.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00299"	"Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4"	"11"	"2"	"3"	"2"	"241"	"26.9"	"5.17"	"670.14"	"4.43"	"2"	"1"	"transport;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component"	"transporter activity"	"Pf13409, Pf13410"	"1192"	"ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685"	"CLIC1"	"hsa:1192; O00299; Q15089; Q502X1"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"51.5"	"43.4"	"61.6"	"83.6"	"92.4"	"92.2"	"178.2"	"174.0"	"117.1"	"164.1"	"241.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y657"	"Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3"	"6"	"1"	"2"	"1"	"262"	"29.6"	"6.96"	"413.73"	"4.41"	"1"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus"	"other molecular function"	"Pf02513"	"10927"	"ENSG00000106723"	"SPIN1"	"A8K0X6; B3KRQ4; hsa:10927; Q7KZJ8; Q9GZT2; Q9H0N7; Q9Y657"	""	""	"0"	"0"	"17.4"	"14.7"	"18.1"	"20.9"	"33.3"	"23.9"	"54.4"	"57.2"	"46.5"	"62.3"	"75.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10768"	"S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2"	"6"	"1"	"1"	"1"	"282"	"31.4"	"7.02"	""	"4.40"	""	"1"	"other metabolic processes"	"cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf00756"	"2098"	"ENSG00000139684"	"ESD"	"hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2"	"Phase I biotransformations, non P450"	"Glutathione conjugation"	"2"	"0"	"11.1"	"8.1"	"20.7"	"19.4"	"26.1"	"26.3"	"41.3"	"38.4"	"18.2"	"41.7"	"54.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02952"	"A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4"	"1"	"2"	"2"	"2"	"1782"	"191.4"	"4.41"	""	"4.40"	""	"2"	"signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf03832, Pf10522"	"9590"	"ENSG00000131016"	"AKAP12"	"hsa:9590; O00310; O00498; Q02952; Q4LE68; Q5SZ80; Q5TGN1; Q68D82; Q99970"	"G protein signaling pathways"	"RHOD GTPase cycle; RHOF GTPase cycle"	"3"	"0"	"20.0"	"7.0"	"16.2"	"20.9"	"29.3"	"32.7"	"94.5"	"76.7"	"46.0"	"69.7"	"110.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15504"	"Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1"	"4"	"1"	"2"	"1"	"423"	"44.8"	"9.19"	"436.11"	"4.39"	"1"	"1"	"transport"	"other membranes;cytosol;nucleus"	"other molecular function"	""	"11097"	"ENSG00000136243"	"NUP42"	"A4D143; B4DP42; hsa:11097; O15504; Q49AE7; Q9BS49"	""	"HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"28"	"0"	"3.4"	"4.1"	"2.3"	"7.0"	"8.1"	"7.7"	"17.7"	"23.7"	"14.8"	"15.7"	"17.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6G9"	"Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3"	"5"	"2"	"4"	"2"	"523"	"56.5"	"6.42"	"525.19"	"4.38"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf05783"	"51143"	"ENSG00000144635"	"DYNC1LI1"	"A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9"	"Ciliary landscape; Intraflagellar transport proteins binding to dynein"	"Separation of Sister Chromatids; Neutrophil degranulation; HCMV Early Events; RHO GTPases Activate Formins; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"15"	"0"	"6.1"	"6.7"	"7.0"	"10.4"	"13.8"	"11.7"	"28.9"	"23.2"	"17.1"	"17.8"	"25.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BU76"	"Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1"	"5"	"1"	"2"	"1"	"263"	"29.4"	"10.02"	"478.57"	"4.36"	"1"	"1"	""	"non-structural extracellular;other cell component"	""	"Pf10159"	"79169"	"ENSG00000143793"	"MMTAG2"	"hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76"	""	"Neutrophil degranulation"	"1"	"0"	"13.3"	"8.5"	"14.9"	"19.7"	"14.7"	"23.4"	"42.5"	"40.1"	"32.1"	"48.2"	"52.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TAD8"	"Smad nuclear-interacting protein 1 OS=Homo sapiens OX=9606 GN=SNIP1 PE=1 SV=1"	"5"	"1"	"2"	"1"	"396"	"45.8"	"9.99"	"673.69"	"4.36"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytosol;nucleus"	"nucleic acid binding activity"	"Pf00498"	"79753"	"ENSG00000163877"	"SNIP1"	"hsa:79753; Q8TAD8; Q96SP9; Q9H9T7"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"13.0"	"9.6"	"16.5"	"16.7"	"26.2"	"23.3"	"60.5"	"59.3"	"34.6"	"45.8"	"53.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96EV2"	"RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3"	"2"	"1"	"2"	"1"	"1170"	"129.9"	"6.93"	"633.38"	"4.36"	"1"	"1"	""	""	""	""	"155435"	"ENSG00000184863"	"RBM33"	"A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0"	""	""	"0"	"0"	"16.0"	"10.4"	"14.7"	"29.8"	"28.7"	"25.8"	"121.0"	"127.5"	"86.4"	"92.4"	"115.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28482"	"Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3"	"6"	"3"	"5"	"3"	"360"	"41.4"	"6.98"	"869.33"	"4.36"	"3"	"2"	"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf00069"	"5594"	"ENSG00000100030"	"MAPK1"	"A8CZ64; hsa:5594; P28482"	"IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularisation processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on Titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; A network map of Macrophage-stimulating protein (MSP) signaling; 4p16.3 copy number variation; Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy; NPHP1 deletion syndrome; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway"	"Neutrophil degranulation; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Regulation of HSF1-mediated heat shock response; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; Nuclear events stimulated by ALK signaling in cancer; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants"	"200"	"0"	"192.1"	"111.0"	"194.3"	"320.3"	"407.6"	"317.6"	"812.8"	"874.7"	"558.7"	"682.5"	"999.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78318"	"Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1"	"6"	"1"	"1"	"1"	"339"	"39.2"	"5.38"	""	"4.35"	""	"1"	"signal transduction;other biological processes"	"cytosol;other cell component"	"enzyme regulator activity;other molecular function"	"Pf04177"	"3476"	"ENSG00000089289"	"IGBP1"	"hsa:3476; P78318; Q8TAB2"	"16p11.2 proximal deletion syndrome"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06730"	"Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2"	"10"	"3"	"4"	"3"	"217"	"25.1"	"6.15"	"623.83"	"4.34"	"2"	"2"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01652"	"1977"	"ENSG00000151247"	"EIF4E"	"B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95"	"Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways"	"L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; mTORC1-mediated signalling"	"31"	"0"	"244.5"	"147.5"	"254.7"	"294.9"	"330.7"	"303.8"	"537.9"	"582.5"	"376.9"	"568.0"	"1104.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P40925"	"Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4"	"7"	"3"	"5"	"3"	"334"	"36.4"	"7.36"	"821.62"	"4.33"	"3"	"2"	"other metabolic processes"	"cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00056, Pf02866"	"4190"	"ENSG00000014641"	"MDH1"	"B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0"	"Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders"	"Gluconeogenesis"	"9"	"0"	"212.1"	"148.9"	"201.0"	"226.9"	"311.3"	"321.9"	"508.3"	"452.3"	"293.1"	"448.1"	"904.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L804"	"Rab11 family-interacting protein 2 OS=Homo sapiens OX=9606 GN=RAB11FIP2 PE=1 SV=1"	"3"	"1"	"2"	"1"	"512"	"58.2"	"9.32"	"393.20"	"4.33"	"1"	"1"	"cell-cell signaling;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00168, Pf09457"	"22841"	"ENSG00000107560"	"RAB11FIP2"	"A6NEI4; hsa:22841; Q3I768; Q7L804; Q9Y2F0"	""	"Vasopressin regulates renal water homeostasis via Aquaporins"	"1"	"0"	"17.0"	"12.5"	"23.3"	"34.2"	"36.0"	"28.8"	"82.1"	"130.1"	"106.6"	"144.5"	"148.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UNZ2"	"NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2"	"5"	"1"	"2"	"1"	"370"	"40.5"	"5.10"	"604.86"	"4.33"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00789, Pf08059, Pf14555"	"55968"	"ENSG00000088833"	"NSFL1C"	"A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2"	"Alstrom syndrome"	"RHOH GTPase cycle"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07108"	"Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2"	"23"	"1"	"2"	"1"	"87"	"10.0"	"6.57"	"546.11"	"4.32"	"1"	"1"	"other metabolic processes;other biological processes"	"ER/Golgi;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00887"	"1622"	"ENSG00000155368"	"DBI"	"B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8"	"Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters"	"Mitochondrial Fatty Acid Beta-Oxidation"	"6"	"0"	"20.2"	"18.2"	"19.9"	"21.8"	"27.1"	"40.8"	"83.9"	"93.7"	"59.5"	"91.0"	"146.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7RTP6"	"[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2"	"1"	"2"	"3"	"2"	"2002"	"224.2"	"5.55"	"263.04"	"4.32"	"1"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf00412, Pf01494, Pf12130"	"57553"	"ENSG00000243156"	"MICAL3"	"B2RXJ5; E9PEF0; hsa:57553; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WWK9"	"Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1"	"3"	"3"	"5"	"3"	"683"	"76.9"	"9.41"	"838.27"	"4.30"	"3"	"2"	"cell cycle OR cell proliferation;other biological processes"	"cytoskeleton;other cell component"	""	"Pf15297"	"26586"	"ENSG00000136108"	"CKAP2"	"A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4"	""	""	"0"	"0"	"109.9"	"62.6"	"96.1"	"115.6"	"156.0"	"115.3"	"911.2"	"856.3"	"614.1"	"780.0"	"1042.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H2K8"	"Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2"	"2"	"2"	"4"	"1"	"898"	"105.3"	"7.30"	"508.11"	"4.30"	"2"	"2"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;other cell component"	"enzyme regulator activity;kinase activity;other molecular function"	"Pf00069"	"51347"	"ENSG00000135090"	"TAOK3"	"hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7"	"MAPK signaling pathway"	"RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BWD1"	"Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2"	"6"	"3"	"5"	"3"	"397"	"41.3"	"6.92"	"817.77"	"4.29"	"3"	"2"	"other metabolic processes"	"cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00108, Pf02803"	"39"	"ENSG00000120437"	"ACAT2"	"B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1"	"Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism"	"Cholesterol biosynthesis"	"6"	"0"	"39.7"	"31.4"	"32.2"	"43.5"	"52.8"	"54.2"	"91.0"	"88.8"	"64.3"	"78.6"	"167.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62877"	"E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1"	"13"	"1"	"2"	"1"	"108"	"12.3"	"6.96"	"499.41"	"4.29"	"1"	"1"	"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf12678"	"9978"	"ENSG00000100387"	"RBX1"	"B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254"	"Cell cycle; Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome"	"Potential therapeutics for SARS; Nuclear events stimulated by ALK signaling in cancer; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; DNA Damage Recognition in GG-NER; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling"	"46"	"0"	"124.4"	"72.0"	"126.8"	"153.5"	"151.6"	"153.7"	"340.3"	"311.6"	"203.5"	"298.5"	"496.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H2W6"	"39S ribosomal protein L46, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1"	"8"	"2"	"3"	"2"	"279"	"31.7"	"7.05"	"629.86"	"4.28"	"2"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus;other cell component"	"other molecular function"	"Pf11788"	"26589"	"ENSG00000259494"	"MRPL46"	"B2RD75; hsa:26589; Q9H2W6; Q9HBU8"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"117.6"	"76.0"	"125.6"	"187.3"	"216.5"	"205.6"	"450.5"	"415.4"	"228.1"	"352.9"	"433.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IUH3"	"RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1"	"4"	"3"	"4"	"3"	"476"	"53.5"	"7.17"	"547.91"	"4.27"	"2"	"2"	"developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076"	"129831"	"ENSG00000155636"	"RBM45"	"hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9"	""	""	"0"	"0"	"106.6"	"71.1"	"97.2"	"130.2"	"161.9"	"148.3"	"545.3"	"448.0"	"322.2"	"358.3"	"409.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q68DK7"	"Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3"	"3"	"1"	"2"	"1"	"614"	"67.1"	"8.92"	"427.02"	"4.26"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf15275, Pf16801"	"339287"	"ENSG00000188895"	"MSL1"	"hsa:339287; Q0VF46; Q68DK7; Q69Z03"	""	"HATs acetylate histones"	"1"	"0"	"3.4"	"3.9"	"8.7"	"5.0"	"6.0"	"6.9"	"20.5"	"25.4"	"14.0"	"16.8"	"24.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2X3"	"Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1"	"2"	"1"	"2"	"1"	"529"	"59.5"	"8.92"	"447.33"	"4.24"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01798, Pf08156"	"51602"	"ENSG00000055044"	"NOP58"	"hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3"	""	"SUMOylation of RNA binding proteins; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"3"	"0"	"38.3"	"17.5"	"30.9"	"33.6"	"57.0"	"40.3"	"175.3"	"192.4"	"72.7"	"151.8"	"263.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22570"	"NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3"	"4"	"1"	"1"	"1"	"491"	"53.8"	"8.44"	""	"4.20"	""	"1"	"other metabolic processes"	"other membranes;mitochondrion"	"other molecular function"	"Pf07992"	"2232"	"ENSG00000161513"	"FDXR"	"B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12"	"Iron-sulfur cluster biogenesis"	"Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin"	"5"	"0"	"0.0"	"3.3"	"6.9"	"12.7"	"15.3"	"14.7"	"23.6"	"27.0"	"28.3"	"38.3"	"63.7"	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15349"	"Ribosomal protein S6 kinase alpha-2 OS=Homo sapiens OX=9606 GN=RPS6KA2 PE=1 SV=2"	"3"	"1"	"2"	"1"	"733"	"83.2"	"8.68"	""	"4.15"	""	"1"	"cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069, Pf00433"	"6196"	"ENSG00000071242"	"RPS6KA2"	"B3KTK9; hsa:6196; Q15349; Q15419; Q59GJ3; Q5TI68; Q96J38; Q9UJN5"	"Prolactin signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling"	"Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK"	"15"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NQA3"	"WAS protein family homolog 6 OS=Homo sapiens OX=9606 GN=WASH6P PE=1 SV=3"	"4"	"1"	"2"	"1"	"447"	"48.0"	"5.67"	"405.37"	"4.14"	"1"	"1"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;cytosol;other cytoplasmic organelle;other cell component"	"cytoskeletal activity"	"Pf11945"	""	""	"WASH6P"	"A6NGF1; Q8N305; Q9NQA3"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UHR5"	"SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1"	"4"	"1"	"2"	"1"	"308"	"33.9"	"4.84"	"460.82"	"4.10"	"1"	"1"	"other biological processes"	"cytoskeleton;nucleus"	""	"Pf07818"	"29115"	"ENSG00000161526"	"SAP30BP"	"B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5"	""	"NoRC negatively regulates rRNA expression"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NQW7"	"Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3"	"3"	"1"	"2"	"1"	"623"	"69.9"	"5.67"	"413.43"	"4.09"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00557, Pf01321, Pf16188, Pf16189"	"7511"	"ENSG00000108039"	"XPNPEP1"	"A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7"	""	""	"0"	"0"	"15.8"	"8.4"	"16.7"	"24.3"	"27.0"	"44.0"	"84.1"	"171.4"	"54.0"	"47.7"	"66.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14579"	"Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3"	"6"	"1"	"2"	"1"	"308"	"34.5"	"5.12"	"710.82"	"4.09"	"1"	"1"	"transport;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus"	"other molecular function"	"Pf04733"	"11316"	"ENSG00000105669"	"COPE"	"A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6"	""	"COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport"	"2"	"0"	"44.6"	"24.7"	"46.6"	"59.7"	"64.5"	"56.1"	"198.8"	"163.2"	"103.5"	"133.4"	"127.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVI7"	"ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A PE=1 SV=2"	"3"	"1"	"1"	"1"	"634"	"71.3"	"8.98"	""	"3.98"	""	"1"	"cell organization and biogenesis;stress response;other biological processes"	"other membranes;mitochondrion"	"other molecular function"	"Pf00004, Pf12037"	"55210"	"ENSG00000197785"	"ATAD3A"	"B3KPB3; D2K8Q1; G3V1I6; hsa:55210; Q5SV23; Q8N275; Q96A50; Q9NVI7"	"1p36 copy number variation syndrome"	""	"1"	"0"	"7.5"	"5.6"	"8.7"	"15.3"	"13.2"	"9.5"	"24.1"	"21.4"	"12.6"	"19.5"	"21.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95785"	"Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2"	"1"	"1"	"2"	"1"	"1651"	"178.6"	"6.86"	"414.89"	"3.97"	"1"	"1"	"other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	""	"58525"	"ENSG00000011451"	"WIZ"	"B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WUQ7"	"Cactin OS=Homo sapiens OX=9606 GN=CACTIN PE=1 SV=3"	"3"	"1"	"2"	"1"	"758"	"88.6"	"9.14"	"358.39"	"3.97"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf09732, Pf10312"	"58509"	"ENSG00000105298"	"CACTIN"	"A6NNA9; A9UL12; hsa:58509; O75229; Q7LE08; Q8WUQ7; Q9BTA6; Q9Y5A4"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"11.9"	"7.7"	"8.3"	"11.3"	"21.0"	"15.0"	"39.1"	"48.3"	"31.4"	"53.0"	"65.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96CX2"	"BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1"	"5"	"1"	"2"	"1"	"325"	"35.7"	"5.64"	"540.44"	"3.93"	"1"	"1"	"cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;other cell component"	"other molecular function"	"Pf02214"	"115207"	"ENSG00000178695"	"KCTD12"	"hsa:115207; Q96CX2"	""	""	"0"	"0"	"10.6"	"5.6"	"9.8"	"12.1"	"16.0"	"17.1"	"34.3"	"39.6"	"13.4"	"22.6"	"30.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86TU7"	"Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1"	"2"	"1"	"2"	"1"	"594"	"67.2"	"5.96"	"377.78"	"3.91"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00856, Pf09273"	"84193"	"ENSG00000183576"	"SETD3"	"A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5"	"Histone modifications"	"PKMTs methylate histone lysines"	"2"	"0"	"6.7"	"4.2"	"5.9"	"11.3"	"12.6"	"13.8"	"55.7"	"54.4"	"39.1"	"60.2"	"131.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20290"	"Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1"	"16"	"2"	"2"	"2"	"206"	"22.2"	"9.38"	"335.02"	"3.88"	"1"	"1"	"transport;developmental processes;other biological processes"	"cytosol;translational apparatus;nucleus;other cell component"	""	"Pf01849"	"689"	"ENSG00000145741"	"BTF3"	"A8K510; hsa:689; P20290; Q13893; Q76M56"	"Orexin receptor pathway"	""	"1"	"0"	"90.3"	"56.2"	"72.6"	"97.3"	"94.4"	"123.5"	"448.6"	"425.7"	"210.4"	"267.4"	"262.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00139"	"Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3"	"2"	"1"	"2"	"1"	"706"	"79.9"	"6.68"	"334.56"	"3.88"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00225"	"3796"	"ENSG00000068796"	"KIF2A"	"A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7"	""	"COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"9"	"0"	"11.6"	"9.0"	"12.0"	"14.7"	"13.6"	"11.9"	"56.7"	"50.8"	"35.7"	"50.8"	"50.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96EY5"	"Multivesicular body subunit 12A OS=Homo sapiens OX=9606 GN=MVB12A PE=1 SV=1"	"7"	"1"	"2"	"1"	"273"	"28.8"	"8.91"	"489.10"	"3.87"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf10240"	"93343"	"ENSG00000141971"	"MVB12A"	"hsa:93343; Q96EY5; Q96I18"	"7q11.23 copy number variation syndrome"	"Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events"	"6"	"0"	"11.8"	"9.5"	"14.1"	"18.5"	"20.4"	"19.2"	"43.6"	"47.1"	"42.3"	"54.1"	"75.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49841"	"Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2"	"16"	"4"	"5"	"4"	"420"	"46.7"	"8.78"	"1380.86"	"3.87"	"3"	"2"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"cytoskeletal activity;kinase activity;other molecular function"	"Pf00069"	"2932"	"ENSG00000082701"	"GSK3B"	"D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47"	"IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; A network map of Macrophage-stimulating protein (MSP) signaling; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)"	"Regulation of HSF1-mediated heat shock response; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein"	"93"	"0"	"60.9"	"29.6"	"58.2"	"76.1"	"103.0"	"85.8"	"300.3"	"299.6"	"216.0"	"270.0"	"396.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BQ15"	"SOSS complex subunit B1 OS=Homo sapiens OX=9606 GN=NABP2 PE=1 SV=1"	"6"	"1"	"2"	"1"	"211"	"22.3"	"9.06"	"427.36"	"3.87"	"1"	"1"	"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01336"	"79035"	"ENSG00000139579"	"NABP2"	"A6NDF8; hsa:79035; Q6XYC8; Q9BQ15"	"Mesodermal commitment pathway"	"RNA polymerase II transcribes snRNA genes"	"2"	"0"	"15.3"	"12.2"	"19.2"	"37.9"	"32.7"	"21.8"	"74.7"	"67.7"	"32.0"	"40.6"	"63.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96GA3"	"Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"475"	"54.8"	"4.91"	"465.36"	"3.87"	"1"	"1"	"transport;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf04180"	"84946"	"ENSG00000135521"	"LTV1"	"hsa:84946; Q96GA3; Q96JX8"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"13.3"	"7.5"	"18.6"	"15.3"	"21.1"	"22.2"	"57.7"	"43.0"	"28.4"	"37.9"	"48.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P56537"	"Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1"	"6"	"1"	"1"	"1"	"245"	"26.6"	"4.68"	""	"3.86"	""	"1"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"translation activity;nucleic acid binding activity"	"Pf01912"	"3692"	"ENSG00000242372"	"EIF6"	"B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5"	"Translation factors; Genetic causes of porto-sinusoidal vascular disease"	""	"2"	"0"	"22.3"	"18.6"	"26.8"	"33.9"	"34.7"	"34.6"	"103.1"	"96.6"	"57.6"	"65.3"	"82.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15651"	"High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2"	"15"	"1"	"2"	"1"	"99"	"10.7"	"9.66"	"277.94"	"3.86"	"1"	"1"	"cell organization and biogenesis"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01101"	"9324"	"ENSG00000118418"	"HMGN3"	"B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7"	""	""	"0"	"0"	"12.4"	"9.1"	"15.6"	"19.4"	"22.7"	"15.8"	"132.6"	"134.7"	"106.7"	"127.4"	"150.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IZP0"	"Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4"	"6"	"2"	"3"	"2"	"508"	"55.0"	"7.06"	"1072.31"	"3.84"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00018, Pf07815"	"10006"	"ENSG00000136754"	"ABI1"	"A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8"	"EGF/EGFR signaling pathway"	"RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs"	"8"	"0"	"44.6"	"48.3"	"72.8"	"76.9"	"83.5"	"84.3"	"131.5"	"144.9"	"126.9"	"130.0"	"131.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L5N1"	"COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1"	"5"	"1"	"2"	"1"	"327"	"36.1"	"5.73"	"503.79"	"3.84"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf01398, Pf13012"	"10980"	"ENSG00000168090"	"COPS6"	"A4D2A3; hsa:10980; O15387; Q7L5N1"	"Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape"	"Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis"	"6"	"0"	"13.1"	"6.8"	"16.8"	"16.1"	"33.1"	"23.0"	"41.4"	"41.2"	"20.2"	"35.2"	"45.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9GZL7"	"Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2"	"5"	"1"	"2"	"1"	"423"	"47.7"	"5.90"	"452.81"	"3.83"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00400, Pf08154"	"55759"	"ENSG00000138442"	"WDR12"	"B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"13.3"	"9.1"	"18.7"	"19.4"	"26.8"	"30.3"	"55.5"	"63.6"	"35.3"	"51.9"	"61.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBN7"	"Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1215"	"131.3"	"5.30"	"323.04"	"3.83"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00850, Pf02148"	"10013"	"ENSG00000094631"	"HDAC6"	"hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7"	"Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome"	"Cilium Assembly; Aggrephagy; Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation"	"16"	"0"	"11.8"	"4.4"	"9.6"	"15.2"	"18.6"	"12.4"	"33.2"	"31.4"	"15.8"	"21.8"	"27.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IYS1"	"Peptidase M20 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2"	"3"	"1"	"2"	"1"	"436"	"47.7"	"5.85"	"399.22"	"3.82"	"1"	"1"	"protein metabolism;other biological processes"	"nucleus"	"other molecular function"	"Pf01546, Pf07687"	"135293"	"ENSG00000146281"	"PM20D2"	"B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1"	""	""	"0"	"0"	"20.5"	"16.8"	"27.6"	"39.8"	"63.8"	"42.7"	"86.8"	"82.8"	"52.3"	"59.7"	"84.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00161"	"Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1"	"7"	"1"	"2"	"1"	"211"	"23.3"	"5.01"	"311.83"	"3.80"	"1"	"1"	"cell-cell signaling;cell organization and biogenesis;stress response;transport"	"plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00835"	"8773"	"ENSG00000092531"	"SNAP23"	"hsa:8773; O00161; O00162; Q13602; Q6IAE3"	"Insulin signaling"	"RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding"	"13"	"0"	"33.4"	"22.4"	"23.6"	"31.1"	"53.6"	"47.3"	"76.6"	"79.8"	"48.7"	"74.3"	"85.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86W34"	"Archaemetzincin-2 OS=Homo sapiens OX=9606 GN=AMZ2 PE=1 SV=2"	"5"	"1"	"2"	"1"	"360"	"41.2"	"8.15"	"391.71"	"3.79"	"1"	"1"	"protein metabolism"	""	"other molecular function"	"Pf07998"	"51321"	"ENSG00000196704"	"AMZ2"	"A6NLD9; B3KR44; hsa:51321; Q5XKF1; Q86W34; Q9NZE2"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14203"	"Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3"	"2"	"2"	"3"	"2"	"1278"	"141.6"	"5.81"	"746.98"	"3.79"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf01302, Pf12455"	"1639"	"ENSG00000204843"	"DCTN1"	"A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2"	""	"MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Signaling by ALK fusions and activated point mutants; XBP1(S) activates chaperone genes"	"6"	"0"	"82.5"	"50.2"	"78.6"	"106.6"	"133.8"	"115.5"	"295.9"	"309.0"	"188.2"	"260.2"	"381.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q3SYG4"	"Protein PTHB1 OS=Homo sapiens OX=9606 GN=BBS9 PE=1 SV=1"	"2"	"1"	"2"	"1"	"887"	"99.2"	"5.55"	"470.55"	"3.79"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	""	"Pf14727, Pf14728"	"27241"	"ENSG00000122507"	"BBS9"	"E9PDC9; hsa:27241; P78514; Q3SYG4; Q7KYS6; Q7KYS7; Q8N570; Q99844; Q99854; Q9Y699; Q9Y6A0"	"Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome"	"BBSome-mediated cargo-targeting to cilium"	"6"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P54819"	"Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2"	"5"	"1"	"2"	"1"	"239"	"26.5"	"7.81"	"403.12"	"3.75"	"1"	"1"	"other metabolic processes"	"cytoskeleton;mitochondrion;other cell component"	"kinase activity;other molecular function"	"Pf00406, Pf05191"	"204"	"ENSG00000004455"	"AK2"	"A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3"	""	"Interconversion of nucleotide di- and triphosphates"	"1"	"0"	"24.5"	"18.1"	"32.8"	"47.2"	"52.8"	"50.3"	"100.1"	"88.9"	"52.7"	"90.1"	"155.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63272"	"Transcription elongation factor SPT4 OS=Homo sapiens OX=9606 GN=SUPT4H1 PE=1 SV=1"	"14"	"1"	"2"	"1"	"117"	"13.2"	"8.06"	"520.72"	"3.75"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf06093"	"6827"	"ENSG00000213246"	"SUPT4H1"	"B2R4X8; D3DTZ4; hsa:6827; P63272; Q16550; Q62387; Q6ZP89"	"Initiation of transcription and translation elongation at the HIV-1 LTR"	"Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes"	"16"	"0"	"53.1"	"52.5"	"72.1"	"91.8"	"92.4"	"84.8"	"202.7"	"197.2"	"153.4"	"148.4"	"178.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H7C9"	"Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1"	"13"	"1"	"2"	"1"	"122"	"13.3"	"8.46"	"438.38"	"3.74"	"1"	"1"	"other biological processes"	"other cell component"	""	"Pf04430"	"28971"	"ENSG00000087884"	"AAMDC"	"hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1"	""	""	"0"	"0"	"9.9"	"6.0"	"12.4"	"10.9"	"16.3"	"20.8"	"35.7"	"37.7"	"28.4"	"26.5"	"38.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15831"	"Serine/threonine-protein kinase STK11 OS=Homo sapiens OX=9606 GN=STK11 PE=1 SV=1"	"4"	"1"	"2"	"1"	"433"	"48.6"	"7.43"	"410.92"	"3.73"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"enzyme regulator activity;kinase activity;other molecular function"	"Pf00069"	"6794"	"ENSG00000118046"	"STK11"	"B2RBX7; E7EW76; hsa:6794; Q15831"	"AMP-activated protein kinase signaling; mir-124 predicted interactions with cell cycle and differentiation ; ATM signaling in development and disease ; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Female steroid hormones in cardiomyocyte energy metabolism"	"Regulation of TP53 Activity through Phosphorylation; Energy dependent regulation of mTOR by LKB1-AMPK; FOXO-mediated transcription of cell death genes; AMPK inhibits chREBP transcriptional activation activity"	"12"	"0"	"3.0"	"2.0"	"4.9"	"3.1"	"7.1"	"5.5"	"13.5"	"30.0"	"24.1"	"40.4"	"49.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P29401"	"Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3"	"2"	"1"	"2"	"1"	"623"	"67.8"	"7.66"	"424.53"	"3.73"	"1"	"1"	"other metabolic processes;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle"	"other molecular function"	"Pf00456, Pf02779, Pf02780"	"7086"	"ENSG00000163931"	"TKT"	"A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3"	"Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways"	"NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate"	"7"	"0"	"10.4"	"5.5"	"11.2"	"13.1"	"7.8"	"10.5"	"49.8"	"54.0"	"33.6"	"48.1"	"103.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75909"	"Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2"	"3"	"1"	"2"	"1"	"580"	"64.2"	"8.41"	"409.56"	"3.73"	"1"	"1"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;kinase activity;other molecular function"	"Pf00134"	"8812"	"ENSG00000090061"	"CCNK"	"hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9"	"Male infertility"	"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes"	"10"	"0"	"6.5"	"7.1"	"7.8"	"10.7"	"16.1"	"9.7"	"26.7"	"28.3"	"20.5"	"27.5"	"31.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6P161"	"39S ribosomal protein L54, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1"	"19"	"1"	"1"	"1"	"138"	"15.8"	"9.60"	""	"3.72"	""	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf08561"	"116541"	"ENSG00000183617"	"MRPL54"	"hsa:116541; Q6P161"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"8.4"	"2.6"	"9.0"	"15.3"	"18.7"	"16.7"	"36.1"	"34.0"	"21.0"	"25.2"	"32.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q53EL6"	"Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2"	"3"	"1"	"2"	"1"	"469"	"51.7"	"5.21"	"382.64"	"3.72"	"1"	"1"	"developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf02847"	"27250"	"ENSG00000150593"	"PDCD4"	"B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834"	"Translation inhibitors in chronically activated PDGFRA cells; A network map of Macrophage-stimulating protein (MSP) signaling; Interferon type I signaling pathways"	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"	"4"	"0"	"17.9"	"10.1"	"15.2"	"18.3"	"25.0"	"20.6"	"41.6"	"41.5"	"31.0"	"37.5"	"28.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14192"	"Four and a half LIM domains protein 2 OS=Homo sapiens OX=9606 GN=FHL2 PE=1 SV=3"	"8"	"2"	"2"	"2"	"279"	"32.2"	"7.55"	"384.60"	"3.72"	"1"	"1"	"developmental processes;other biological processes"	"cytoskeleton;nucleus"	"other molecular function"	"Pf00412"	"2274"	"ENSG00000115641"	"FHL2"	"hsa:2274; Q13229; Q13644; Q14192; Q2I5I4; Q5TM15; Q9P294"	"Androgen receptor signaling pathway; RANKL/RANK signaling pathway; Ectoderm differentiation; VEGFA-VEGFR2 signaling"	"PPARA activates gene expression"	"5"	"0"	"76.5"	"66.2"	"89.7"	"99.4"	"111.3"	"98.9"	"169.0"	"166.0"	"158.6"	"173.0"	"220.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P54105"	"Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1"	"5"	"1"	"2"	"1"	"237"	"26.2"	"4.11"	"483.38"	"3.69"	"1"	"1"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	""	"Pf03517"	"1207"	"ENSG00000074201"	"CLNS1A"	"B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3"	""	"snRNP Assembly"	"1"	"0"	"22.9"	"31.5"	"36.3"	"40.2"	"45.0"	"45.4"	"99.6"	"99.1"	"71.4"	"83.3"	"118.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N806"	"Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2"	"3"	"1"	"2"	"1"	"425"	"48.0"	"4.81"	"382.82"	"3.68"	"1"	"1"	"protein metabolism;other metabolic processes"	""	"other molecular function"	"Pf02207"	"55148"	"ENSG00000012963; ENSG00000278787"	"UBR7"	"hsa:55148; Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P47914"	"60S ribosomal protein L29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2"	"9"	"1"	"2"	"1"	"159"	"17.7"	"11.66"	"362.02"	"3.66"	"1"	"1"	"protein metabolism;other metabolic processes;developmental processes"	"cytosol;translational apparatus;other cell component"	"other molecular function"	"Pf01779"	"6159"	"ENSG00000162244"	"RPL29"	"A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"28.7"	"11.0"	"17.8"	"25.5"	"36.7"	"32.9"	"128.2"	"105.3"	"75.0"	"88.7"	"83.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00255"	"Menin OS=Homo sapiens OX=9606 GN=MEN1 PE=1 SV=4"	"2"	"1"	"2"	"1"	"615"	"68.0"	"6.55"	"283.13"	"3.66"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf05053"	"4221"	"ENSG00000133895"	"MEN1"	"A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2; hsa:4221; O00255; O00632; Q9BUF0; Q9BUK2"	"10q11.21q11.23 copy number variation syndrome"	"RHO GTPases activate IQGAPs; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation"	"8"	"0"	"12.0"	"4.8"	"12.4"	"25.5"	"36.4"	"25.0"	"67.1"	"59.3"	"33.5"	"47.8"	"49.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10155"	"60 kDa SS-A/Ro ribonucleoprotein OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2"	"3"	"1"	"2"	"1"	"538"	"60.6"	"8.03"	"563.80"	"3.66"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf05731"	"6738"	"ENSG00000116747"	"RO60"	"B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6"	""	""	"0"	"0"	"30.9"	"25.0"	"30.9"	"42.6"	"50.6"	"35.0"	"85.4"	"84.7"	"42.7"	"69.4"	"94.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6M4"	"Casein kinase I isoform gamma-3 OS=Homo sapiens OX=9606 GN=CSNK1G3 PE=1 SV=2"	"3"	"1"	"2"	"1"	"447"	"51.4"	"9.22"	"480.91"	"3.65"	"1"	"1"	"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069, Pf12605"	"1456"	"ENSG00000151292"	"CSNK1G3"	"A8K040; B4DSH2; B7Z9Q4; E7EVD0; hsa:1456; Q86WZ7; Q9Y6M3; Q9Y6M4"	"Hedgehog signaling pathway"	""	"1"	"0"	"8.9"	"5.8"	"11.8"	"9.3"	"13.1"	"10.0"	"45.8"	"51.4"	"24.4"	"43.6"	"53.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P60604"	"Ubiquitin-conjugating enzyme E2 G2 OS=Homo sapiens OX=9606 GN=UBE2G2 PE=1 SV=1"	"15"	"1"	"2"	"1"	"165"	"18.6"	"4.70"	""	"3.65"	""	"1"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"ER/Golgi;other cell component"	"other molecular function"	"Pf00179"	"7327"	"ENSG00000184787"	"UBE2G2"	"A6NMQ7; A8K3L4; D3DSL7; hsa:7327; P56554; P60604"	"Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway"	"Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes"	"4"	"0"	"10.6"	"2.5"	"5.3"	"10.6"	"15.2"	"10.4"	"29.6"	"23.1"	"12.1"	"20.2"	"25.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96AY3"	"Peptidyl-prolyl cis-trans isomerase FKBP10 OS=Homo sapiens OX=9606 GN=FKBP10 PE=1 SV=1"	"2"	"1"	"2"	"1"	"582"	"64.2"	"5.62"	"419.96"	"3.65"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes"	"other membranes;mitochondrion;ER/Golgi"	"other molecular function"	"Pf00254, Pf13202"	"60681"	"ENSG00000141756"	"FKBP10"	"hsa:60681; Q7Z3R4; Q96AY3; Q9H3N3; Q9H6J3; Q9H6N5; Q9UF89"	"Type I collagen synthesis in the context of osteogenesis imperfecta"	""	"1"	"0"	"16.1"	"16.2"	"20.3"	"33.7"	"29.9"	"35.1"	"50.0"	"42.5"	"39.2"	"55.9"	"77.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H2H8"	"Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1"	"8"	"1"	"2"	"1"	"161"	"18.1"	"6.79"	"374.78"	"3.64"	"1"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00160"	"53938"	"ENSG00000240344"	"PPIL3"	"hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"16.5"	"6.5"	"19.8"	"26.9"	"30.1"	"21.1"	"76.6"	"81.6"	"50.4"	"69.0"	"104.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15008"	"26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1"	"3"	"1"	"2"	"1"	"389"	"45.5"	"5.62"	"574.53"	"3.63"	"1"	"1"	"protein metabolism;other metabolic processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	""	"Pf01399, Pf10602"	"9861"	"ENSG00000163636"	"PSMD6"	"A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; ABC-family proteins mediated transport; Neutrophil degranulation; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-1 signaling; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"64"	"0"	"45.3"	"30.6"	"52.5"	"80.0"	"101.0"	"92.5"	"155.2"	"149.4"	"72.8"	"115.1"	"157.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P24666"	"Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3"	"7"	"1"	"2"	"1"	"158"	"18.0"	"6.74"	"295.41"	"3.61"	"1"	"1"	"protein metabolism;other metabolic processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf01451"	"52"	"ENSG00000143727"	"ACP1"	"A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"40.2"	"18.4"	"38.4"	"40.8"	"62.8"	"61.9"	"84.7"	"75.4"	"50.5"	"78.8"	"95.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P05091"	"Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2"	"2"	"1"	"2"	"1"	"517"	"56.3"	"7.05"	"420.31"	"3.61"	"1"	"1"	"other metabolic processes;other biological processes"	"mitochondrion"	"other molecular function"	"Pf00171"	"217"	"ENSG00000111275"	"ALDH2"	"B4DW54; E7EUE5; hsa:217; P05091; Q03639; Q6IB13; Q6IV71"	"Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity"	"Smooth Muscle Contraction; Ethanol oxidation; Metabolism of serotonin"	"7"	"0"	"5.3"	"4.3"	"9.5"	"9.4"	"10.9"	"12.5"	"16.0"	"13.6"	"10.9"	"12.6"	"24.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75348"	"V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3"	"17"	"2"	"3"	"2"	"118"	"13.7"	"8.79"	"682.09"	"3.59"	"2"	"1"	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"transporter activity;other molecular function"	"Pf03179"	"9550"	"ENSG00000136888"	"ATP6V1G1"	"hsa:9550; O75348; Q6IB33"	"Osteoclast signaling; Proximal tubule transport"	"Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport"	"7"	"0"	"32.0"	"20.7"	"30.7"	"48.0"	"53.4"	"48.8"	"151.7"	"131.6"	"105.4"	"121.5"	"155.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WUA2"	"Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1"	"4"	"1"	"1"	"1"	"492"	"57.2"	"5.92"	""	"3.58"	""	"1"	"protein metabolism;other metabolic processes"	"cytosol;nucleus"	"other molecular function"	"Pf00076, Pf00160"	"85313"	"ENSG00000131013"	"PPIL4"	"B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"4.8"	"3.8"	"2.9"	"9.0"	"10.9"	"9.7"	"22.0"	"19.5"	"19.4"	"21.8"	"20.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16527"	"Cysteine and glycine-rich protein 2 OS=Homo sapiens OX=9606 GN=CSRP2 PE=1 SV=3"	"7"	"1"	"2"	"1"	"193"	"20.9"	"8.62"	"433.14"	"3.56"	"1"	"1"	"cell organization and biogenesis;other biological processes"	"cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00412"	"1466"	"ENSG00000175183"	"CSRP2"	"hsa:1466; Q16527; Q93030"	"Mesodermal commitment pathway; VEGFA-VEGFR2 signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity"	""	"3"	"0"	"4.1"	"2.4"	"6.8"	"8.8"	"7.8"	"10.3"	"21.3"	"22.7"	"13.3"	"16.2"	"19.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRW3"	"DNA dC->dU-editing enzyme APOBEC-3C OS=Homo sapiens OX=9606 GN=APOBEC3C PE=1 SV=2"	"12"	"2"	"2"	"2"	"190"	"22.8"	"7.59"	"241.72"	"3.55"	"1"	"1"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf18782"	"27350"	"ENSG00000244509"	"APOBEC3C"	"B2R884; hsa:27350; Q5JZ92; Q7Z2N7; Q96F12; Q9NRW3"	""	"Formation of the Editosome"	"2"	"0"	"26.5"	"14.1"	"21.4"	"25.2"	"29.1"	"28.2"	"130.2"	"116.5"	"46.7"	"58.3"	"89.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q4J6C6"	"Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1"	"3"	"2"	"2"	"2"	"727"	"83.9"	"6.38"	"330.93"	"3.55"	"1"	"1"	"protein metabolism;transport;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;nucleus"	"other molecular function"	"Pf00326, Pf02897"	"9581"	"ENSG00000138078"	"PREPL"	"A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7"	"Primary ovarian insufficiency"	""	"1"	"0"	"16.5"	"14.2"	"33.9"	"40.7"	"37.9"	"31.9"	"79.9"	"75.4"	"31.0"	"55.2"	"78.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60645"	"Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3"	"2"	"1"	"2"	"1"	"745"	"85.5"	"6.29"	"493.85"	"3.55"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf06046"	"11336"	"ENSG00000180104"	"EXOC3"	"hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4"	"Ciliary landscape"	"Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium"	"4"	"0"	"13.9"	"9.3"	"14.1"	"17.2"	"21.2"	"11.0"	"40.2"	"52.2"	"66.7"	"93.8"	"93.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12769"	"Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3"	"1"	"1"	"2"	"1"	"1436"	"162.0"	"5.50"	"392.55"	"3.55"	"1"	"1"	"other metabolic processes;transport;developmental processes"	"cytosol;nucleus"	"other molecular function"	"Pf11715"	"23279"	"ENSG00000030066"	"NUP160"	"B4DYE8; B4E2J9; hsa:23279; Q08AD3; Q12769; Q7Z5X6; Q96GB3; Q9H660"	""	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses"	"35"	"0"	"34.1"	"9.9"	"22.8"	"45.1"	"45.4"	"36.3"	"93.6"	"69.9"	"45.6"	"60.8"	"65.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13685"	"Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2"	"3"	"1"	"1"	"1"	"434"	"46.7"	"4.42"	""	"3.54"	""	"1"	"developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00400"	"14"	"ENSG00000127837"	"AAMP"	"hsa:14; Q13685; Q8WUJ9; Q96H92"	"Nucleotide-binding oligomerization domain (NOD) pathway"	"Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF"	"5"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13098"	"COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4"	"5"	"2"	"3"	"2"	"491"	"55.5"	"6.74"	"707.69"	"3.54"	"2"	"1"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity"	"Pf01399, Pf10602"	"2873"	"ENSG00000169727"	"GPS1"	"hsa:2873; Q13098; Q8NA10; Q9BWL1"	""	"Neddylation; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER"	"5"	"0"	"92.7"	"30.6"	"40.9"	"40.7"	"119.1"	"111.5"	"125.4"	"1915.3"	"57.5"	"46.7"	"97.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NI36"	"WD repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=WDR36 PE=1 SV=1"	"1"	"1"	"2"	"1"	"951"	"105.3"	"7.53"	"353.61"	"3.53"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf00400, Pf04192, Pf12894"	"134430"	""	"WDR36"	"A2RUS4; hsa:134430; Q68E02; Q8N1Q2; Q8NI36"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"8.3"	"3.4"	"8.3"	"12.6"	"12.3"	"14.0"	"32.8"	"29.0"	"17.2"	"23.0"	"42.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBW8"	"COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1"	"5"	"1"	"2"	"1"	"275"	"30.3"	"8.22"	"431.60"	"3.53"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf01399, Pf18392"	"50813"	"ENSG00000111652"	"COPS7A"	"A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4"	"Ciliary landscape"	"Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER"	"5"	"0"	"10.9"	"6.8"	"11.6"	"14.2"	"17.0"	"14.8"	"28.5"	"25.1"	"12.3"	"25.6"	"41.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z4G4"	"tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1"	"3"	"1"	"2"	"1"	"463"	"53.4"	"7.78"	"450.68"	"3.51"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01170"	"60487"	"ENSG00000066651"	"TRMT11"	"E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13"	""	"tRNA modification in the nucleus and cytosol"	"1"	"0"	"6.6"	"0.0"	"8.3"	"6.7"	"11.6"	"8.2"	"23.7"	"22.2"	"15.8"	"24.4"	"24.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9GZZ1"	"N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1"	"8"	"1"	"2"	"1"	"169"	"19.4"	"8.81"	"354.49"	"3.51"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00583"	"80218"	"ENSG00000121579"	"NAA50"	"D3DN74; hsa:80218; Q68DQ1; Q9GZZ1"	"Metapathway biotransformation Phase I and II"	""	"1"	"0"	"2.9"	"3.0"	"6.2"	"5.4"	"9.7"	"6.8"	"24.7"	"24.9"	"16.0"	"28.0"	"29.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49207"	"60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3"	"15"	"2"	"4"	"2"	"117"	"13.3"	"11.47"	"977.94"	"3.50"	"2"	"1"	"protein metabolism;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01199"	"6164"	"ENSG00000109475"	"RPL34"	"hsa:6164; P49207; Q6FG66; Q9BUZ2"	"Cytoplasmic ribosomal proteins"	"Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"196.5"	"148.2"	"190.4"	"222.9"	"254.5"	"252.5"	"1021.1"	"852.9"	"778.3"	"925.1"	"928.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P38432"	"Coilin OS=Homo sapiens OX=9606 GN=COIL PE=1 SV=1"	"3"	"2"	"3"	"2"	"576"	"62.6"	"9.07"	"558.81"	"3.47"	"2"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf15862"	"8161"	"ENSG00000121058"	"COIL"	"B2R931; hsa:8161; P38432"	""	""	"0"	"0"	"63.1"	"35.7"	"50.5"	"81.4"	"88.7"	"85.4"	"225.3"	"217.4"	"129.5"	"207.2"	"279.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6W5"	"Wiskott-Aldrich syndrome protein family member 2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3"	"3"	"1"	"2"	"1"	"498"	"54.3"	"5.53"	"409.68"	"3.44"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf02205"	"10163"	"ENSG00000158195"	"WASF2"	"B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5"	"Regulation of actin cytoskeleton"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway"	"8"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49840"	"Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2"	"4"	"1"	"2"	"1"	"483"	"50.9"	"8.75"	"348.55"	"3.43"	"1"	"1"	"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function"	"Pf00069"	"2931"	"ENSG00000105723"	"GSK3A"	"hsa:2931; O14959; P49840"	"IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation"	"Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein"	"17"	"0"	"11.8"	"7.3"	"8.8"	"18.1"	"18.7"	"21.6"	"68.9"	"68.9"	"50.4"	"61.8"	"76.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25440"	"Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2"	"2"	"1"	"2"	"1"	"801"	"88.0"	"9.09"	"393.90"	"3.43"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00439, Pf17035"	"6046"	"ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307"	"BRD2"	"A2AAU0; B0S7P0; B1AZT1; hsa:6046; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4"	""	"RUNX3 regulates p14-ARF"	"1"	"0"	"4.3"	"4.5"	"3.7"	"6.3"	"6.5"	"4.9"	"15.1"	"13.4"	"13.4"	"28.5"	"36.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P84022"	"Mothers against decapentaplegic homolog 3 OS=Homo sapiens OX=9606 GN=SMAD3 PE=1 SV=1"	"3"	"1"	"2"	"1"	"425"	"48.1"	"7.15"	"303.24"	"3.42"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf03165, Pf03166"	"4088"	"ENSG00000166949"	"SMAD3"	"A8K4B6; B7Z4Z5; B7Z6M9; B7Z9Q2; F5H383; hsa:4088; O09064; O09144; O14510; O35273; P84022; Q92940; Q93002; Q9GKR4"	"Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularisation processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; GDNF signaling; Urotensin-II-mediated signaling pathway; A network map of Macrophage-stimulating protein (MSP) signaling; TGF-beta receptor signaling; DNA damage response (only ATM dependent)"	"Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; Interleukin-37 signaling; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer"	"55"	"0"	"9.4"	"5.4"	"11.2"	"13.8"	"19.6"	"20.8"	"45.8"	"53.1"	"62.2"	"121.4"	"133.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00232"	"26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3"	"3"	"1"	"2"	"1"	"456"	"52.9"	"7.65"	"324.63"	"3.42"	"1"	"1"	"protein metabolism;other metabolic processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	""	"Pf01399, Pf18098"	"5718"	"ENSG00000197170"	"PSMD12"	"A6NP15; hsa:5718; O00232; Q53HA2; Q6P053"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"65"	"0"	"13.9"	"11.4"	"13.4"	"22.1"	"29.7"	"27.5"	"50.6"	"47.5"	"24.2"	"30.9"	"49.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6IAA8"	"Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2"	"8"	"1"	"2"	"1"	"161"	"17.7"	"5.15"	"420.70"	"3.42"	"1"	"1"	"cell organization and biogenesis;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;other cytoplasmic organelle"	"other molecular function"	"Pf15454"	"55004"	"ENSG00000149357"	"LAMTOR1"	"hsa:55004; Q6IAA8; Q8WZ09; Q9NWT0"	"Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins"	"Neutrophil degranulation; mTORC1-mediated signalling; Regulation of PTEN gene transcription; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; Amino acids regulate mTORC1; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; RHOH GTPase cycle"	"17"	"0"	"30.2"	"13.6"	"20.3"	"30.6"	"39.0"	"35.7"	"61.0"	"73.8"	"34.5"	"69.8"	"84.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49459"	"Ubiquitin-conjugating enzyme E2 A OS=Homo sapiens OX=9606 GN=UBE2A PE=1 SV=2"	"7"	"1"	"2"	"1"	"152"	"17.3"	"5.15"	"339.83"	"3.41"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00179"	"7319"	"ENSG00000077721"	"UBE2A"	"A6NFE9; A6NGR2; A6NMF5; B2R7R9; D3DWI1; hsa:7319; P49459; Q4TTG1; Q96FX4"	""	"E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation"	"3"	"0"	"21.3"	"19.4"	"28.0"	"34.6"	"43.1"	"40.7"	"76.7"	"83.2"	"62.1"	"58.9"	"81.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5JTJ3"	"Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1"	"11"	"1"	"2"	"1"	"125"	"14.1"	"8.25"	"311.83"	"3.41"	"1"	"1"	"cell organization and biogenesis;other metabolic processes"	"plasma membrane;other membranes;mitochondrion;nucleus"	"other molecular function"	"Pf02297"	"388753"	"ENSG00000168275"	"COA6"	"hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88"	"Mitochondrial complex IV assembly"	"Mitochondrial protein import"	"2"	"0"	"14.9"	"7.6"	"11.6"	"24.9"	"29.4"	"27.0"	"55.3"	"59.2"	"43.0"	"70.1"	"84.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96IZ0"	"PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1"	"4"	"1"	"2"	"1"	"340"	"36.5"	"5.41"	"507.68"	"3.39"	"1"	"1"	"cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	""	"5074"	"ENSG00000177425"	"PAWR"	"hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0"	""	""	"0"	"0"	"13.2"	"9.5"	"6.6"	"13.6"	"18.5"	"15.6"	"31.8"	"27.0"	"17.1"	"29.8"	"28.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49721"	"Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1"	"7"	"2"	"2"	"2"	"201"	"22.8"	"7.02"	"234.41"	"3.39"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf00227"	"5690"	"ENSG00000126067"	"PSMB2"	"D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"33.1"	"24.9"	"42.5"	"50.0"	"104.8"	"57.5"	"180.5"	"243.0"	"118.9"	"177.4"	"169.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95163"	"Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3"	"1"	"1"	"2"	"1"	"1332"	"150.2"	"5.94"	"402.84"	"3.39"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04762"	"8518"	"ENSG00000070061"	"ELP1"	"hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87"	""	"HATs acetylate histones"	"1"	"0"	"23.8"	"13.2"	"24.5"	"29.4"	"37.1"	"31.8"	"68.9"	"100.3"	"37.5"	"54.1"	"80.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BXC9"	"Bardet-Biedl syndrome 2 protein OS=Homo sapiens OX=9606 GN=BBS2 PE=1 SV=1"	"2"	"1"	"2"	"1"	"721"	"79.8"	"6.15"	"333.14"	"3.38"	"1"	"1"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"10.4"	"6.0"	"13.4"	"14.1"	"13.9"	"12.7"	"36.0"	"41.7"	"46.9"	"74.8"	"95.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96GM8"	"Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"510"	"56.5"	"7.18"	"317.33"	"3.38"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00642, Pf04857"	"114034"	"ENSG00000132773"	"TOE1"	"B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846"	""	""	"0"	"0"	"13.9"	"7.1"	"15.4"	"16.4"	"22.0"	"18.7"	"41.0"	"37.3"	"27.6"	"38.5"	"31.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94813"	"Slit homolog 2 protein OS=Homo sapiens OX=9606 GN=SLIT2 PE=1 SV=1"	"2"	"2"	"3"	"2"	"1529"	"169.8"	"7.06"	"787.98"	"3.38"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;other membranes;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	"Pf00008, Pf01462, Pf01463, Pf02210, Pf12661, Pf13855"	"9353"	"ENSG00000145147"	"SLIT2"	"A0A0A6YYB8; B7ZLR5; hsa:9353; O94813; O95710; Q17RU3; Q9Y5Q7"	"Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; Genes controlling nephrogenesis; GDNF/RET signaling axis; Development of ureteric collection system"	"Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity"	"13"	"0"	"10.7"	"8.0"	"10.1"	"12.2"	"14.2"	"11.7"	"50.1"	"55.7"	"35.8"	"46.6"	"61.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00170"	"AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=2"	"3"	"1"	"2"	"1"	"330"	"37.6"	"6.29"	"233.87"	"3.37"	"1"	"1"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"24.5"	"15.8"	"29.2"	"32.3"	"55.2"	"36.8"	"98.9"	"106.5"	"58.0"	"76.8"	"88.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WVM8"	"Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4"	"2"	"1"	"2"	"1"	"642"	"72.3"	"6.27"	"362.50"	"3.35"	"1"	"1"	"stress response;transport;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi"	"other molecular function"	"Pf00995"	"23256"	"ENSG00000092108"	"SCFD1"	"A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8"	""	"RHOA GTPase cycle; COPII-mediated vesicle transport"	"2"	"0"	"13.2"	"6.3"	"13.7"	"19.5"	"21.8"	"21.5"	"46.0"	"46.1"	"32.7"	"35.4"	"51.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P28072"	"Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4"	"5"	"1"	"2"	"1"	"239"	"25.3"	"4.92"	"409.52"	"3.33"	"1"	"1"	"protein metabolism;other metabolic processes"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00227"	"5694"	"ENSG00000142507"	"PSMB6"	"hsa:5694; P28072; Q96J55"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"62"	"0"	"54.4"	"45.2"	"56.4"	"77.7"	"84.2"	"96.6"	"266.7"	"255.2"	"181.8"	"217.6"	"273.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96T88"	"E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"793"	"89.8"	"7.56"	"300.48"	"3.32"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00240, Pf00628, Pf02182, Pf12148"	"29128"	"ENSG00000276043"	"UHRF1"	"A0JBR2; A8K024; B2RBA9; hsa:29128; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7"	"Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma"	"DNA methylation"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35249"	"Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2"	"6"	"1"	"2"	"1"	"363"	"39.7"	"8.02"	"319.46"	"3.32"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00004, Pf08542"	"5984"	"ENSG00000163918"	"RFC4"	"B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7"	"Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair"	"Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER"	"28"	"0"	"14.5"	"14.1"	"16.5"	"20.2"	"25.5"	"25.8"	"60.7"	"51.1"	"32.9"	"53.4"	"51.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5T749"	"Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1"	"2"	"1"	"2"	"1"	"579"	"64.1"	"8.27"	"355.53"	"3.31"	"1"	"1"	""	"other cell component"	""	""	"448834"	"ENSG00000203786"	"KPRP"	"hsa:448834; Q5T749"	""	""	"0"	"0"	"38.3"	"32.6"	"44.2"	"45.8"	"72.6"	"57.7"	"129.0"	"188.3"	"79.3"	"104.6"	"119.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6PI98"	"INO80 complex subunit C OS=Homo sapiens OX=9606 GN=INO80C PE=1 SV=1"	"7"	"1"	"2"	"1"	"192"	"20.6"	"10.02"	"497.39"	"3.30"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus"	""	"Pf08265"	"125476"	"ENSG00000153391"	"INO80C"	"B4DUI4; E9PCS7; hsa:125476; Q6PI98; Q86WR1; Q8N994"	""	"UCH proteinases; DNA Damage Recognition in GG-NER"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5JXB2"	"Putative ubiquitin-conjugating enzyme E2 N-like OS=Homo sapiens OX=9606 GN=UBE2NL PE=1 SV=1"	"7"	"1"	"2"	"1"	"153"	"17.4"	"5.92"	"403.67"	"3.28"	"1"	"1"	"protein metabolism;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00179"	"389898"	""	"UBE2NL"	"E9KL27; hsa:389898; Q5JXB2"	""	""	"0"	"0"	"32.2"	"19.6"	"27.7"	"43.1"	"59.7"	"53.8"	"108.9"	"64.5"	"35.3"	"61.8"	"138.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TAM2"	"Tetratricopeptide repeat protein 8 OS=Homo sapiens OX=9606 GN=TTC8 PE=1 SV=2"	"4"	"1"	"1"	"1"	"541"	"61.5"	"6.80"	""	"3.28"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf13176, Pf13432"	"123016"	"ENSG00000165533"	"TTC8"	"A6NFG2; B3KWA5; hsa:123016; Q67B97; Q86SY0; Q86TV9; Q86U26; Q8NDH9; Q8TAM2; Q96DG8"	"Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome"	"BBSome-mediated cargo-targeting to cilium"	"6"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H7B2"	"Ribosome production factor 2 homolog OS=Homo sapiens OX=9606 GN=RPF2 PE=1 SV=2"	"6"	"1"	"2"	"1"	"306"	"35.6"	"9.99"	"487.00"	"3.26"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf04427"	"84154"	"ENSG00000197498"	"RPF2"	"hsa:84154; Q5VXN1; Q8N4A1; Q9H7B2"	""	""	"0"	"0"	"5.3"	"2.6"	"5.7"	"7.1"	"13.6"	"11.7"	"47.3"	"39.5"	"17.3"	"23.7"	"25.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12888"	"TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1972"	"213.4"	"4.70"	""	"3.26"	""	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf09038, Pf18428"	"7158"	"ENSG00000067369"	"TP53BP1"	"F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4"	"ATM signaling pathway; ATM signaling in development and disease"	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); SUMOylation of transcription factors"	"7"	"0"	"7.5"	"5.2"	"10.6"	"15.5"	"16.2"	"17.8"	"33.0"	"36.3"	"19.5"	"32.3"	"36.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35080"	"Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3"	"16"	"2"	"3"	"2"	"140"	"15.0"	"6.99"	"546.16"	"3.25"	"2"	"1"	"cell organization and biogenesis;other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00235"	"5217"	"ENSG00000070087"	"PFN2"	"B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2"	"Physico-chemical features and toxicity-associated pathways"	"RHO GTPases Activate Formins; Signaling by ROBO receptors"	"3"	"0"	"35.5"	"24.7"	"37.5"	"46.6"	"45.8"	"47.6"	"83.0"	"99.9"	"59.3"	"80.8"	"117.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q69YN4"	"Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2"	"1"	"1"	"2"	"1"	"1812"	"201.9"	"5.01"	"334.53"	"3.25"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	""	"Pf15912"	"25962"	"ENSG00000164944"	"VIRMA"	"hsa:25962; Q2M1N0; Q69YN4; Q6AHX9; Q6NT78; Q7Z6C7; Q8IXH4; Q9BTH4; Q9H9C9; Q9NWR3; Q9P2B8; Q9UFW1"	""	""	"0"	"0"	"3.6"	"4.8"	"6.6"	"12.3"	"11.7"	"15.9"	"26.4"	"17.6"	"12.7"	"21.6"	"25.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P80303"	"Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3"	"3"	"1"	"2"	"1"	"420"	"50.2"	"5.12"	"378.09"	"3.24"	"1"	"1"	"signal transduction"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf13499"	"4925"	"ENSG00000070081"	"NUCB2"	"A8K642; D3DQX5; hsa:4925; P80303; Q8NFT5; V9HW75"	""	""	"0"	"0"	"15.9"	"8.6"	"14.2"	"13.4"	"26.6"	"23.0"	"44.6"	"38.3"	"27.4"	"37.9"	"57.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UGI8"	"Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1"	"5"	"1"	"1"	"1"	"421"	"48.0"	"7.68"	""	"3.23"	""	"1"	"other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf00412, Pf06297"	"26136"	"ENSG00000135269"	"TES"	"A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8"	""	""	"0"	"0"	"7.7"	"3.9"	"7.0"	"6.7"	"11.9"	"8.5"	"19.4"	"11.9"	"8.5"	"15.7"	"19.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75531"	"Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1"	"13"	"1"	"2"	"1"	"89"	"10.1"	"6.09"	"374.14"	"3.23"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02961"	"8815"	"ENSG00000175334"	"BANF1"	"hsa:8815; O60558; O75531; Q6FGG7"	"Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy; Progeria-associated lipodystrophy"	"Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation"	"11"	"0"	"22.3"	"14.5"	"27.1"	"25.2"	"33.3"	"34.7"	"59.0"	"56.1"	"47.0"	"76.4"	"90.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRX1"	"RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1"	"7"	"1"	"2"	"1"	"252"	"27.9"	"9.73"	"388.77"	"3.23"	"1"	"1"	"other biological processes"	"cytosol;nucleus;other cell component"	""	""	"56902"	"ENSG00000115946"	"PNO1"	"A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"Q9Y223"	"Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1"	"2"	"1"	"2"	"1"	"722"	"79.2"	"6.80"	"314.74"	"3.22"	"1"	"1"	"cell adhesion;other metabolic processes"	"cytosol;other cell component"	"kinase activity;other molecular function"	"Pf00480, Pf02350"	"10020"	"ENSG00000159921"	"GNE"	"A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223"	""	"Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TER5"	"Rho guanine nucleotide exchange factor 40 OS=Homo sapiens OX=9606 GN=ARHGEF40 PE=1 SV=3"	"1"	"1"	"1"	"1"	"1519"	"164.6"	"6.15"	""	"3.21"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"enzyme regulator activity"	"Pf00621"	"55701"	"ENSG00000165801"	"ARHGEF40"	"A5PL07; hsa:55701; Q8TER5; Q9BWP5; Q9H7L6; Q9NTF9; Q9NW24"	""	"RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events"	"4"	"0"	"57.4"	"29.1"	"40.3"	"82.2"	"100.0"	"89.4"	"122.3"	"106.4"	"69.0"	"80.1"	"107.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95456"	"Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1"	"7"	"1"	"2"	"1"	"288"	"32.8"	"7.17"	"264.13"	"3.21"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf16094"	"8624"	"ENSG00000183527"	"PSMG1"	"B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TDN6"	"Ribosome biogenesis protein BRX1 homolog OS=Homo sapiens OX=9606 GN=BRIX1 PE=1 SV=2"	"4"	"1"	"2"	"1"	"353"	"41.4"	"9.92"	"318.91"	"3.21"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf04427"	"55299"	"ENSG00000113460"	"BRIX1"	"A8K0P5; hsa:55299; Q3ZTT4; Q8N453; Q8TDN6; Q96DH1"	"Gastric cancer network 2"	""	"1"	"0"	"16.4"	"9.1"	"14.6"	"16.5"	"19.7"	"13.2"	"96.1"	"94.9"	"59.2"	"85.8"	"176.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96QZ7"	"Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAGI1 PE=1 SV=3"	"1"	"1"	"2"	"1"	"1491"	"164.5"	"7.58"	"313.01"	"3.20"	"1"	"1"	"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00397, Pf00595, Pf00625, Pf16663, Pf16666"	"9223"	"ENSG00000151276; ENSG00000282956"	"MAGI1"	"A8K188; hsa:9223; O00309; O43863; O75085; Q96QZ7; Q96QZ8; Q96QZ9"	"Pathways affected in adenoid cystic carcinoma"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N1G2"	"Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"835"	"95.3"	"7.05"	"364.97"	"3.19"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01585, Pf01728"	"23070"	"ENSG00000137200"	"CMTR1"	"A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95168"	"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 OS=Homo sapiens OX=9606 GN=NDUFB4 PE=1 SV=3"	"8"	"1"	"2"	"1"	"129"	"15.2"	"9.85"	"329.18"	"3.19"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;stress response;transport"	"other membranes;mitochondrion;nucleus"	"transporter activity"	"Pf07225"	"4710"	"ENSG00000065518"	"NDUFB4"	"B2RUY3; B9EJC7; hsa:4710; O95168"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"5"	"0"	"88.1"	"68.3"	"72.9"	"99.3"	"138.2"	"98.3"	"244.5"	"213.0"	"162.6"	"273.4"	"426.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16864"	"V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2"	"10"	"1"	"2"	"1"	"119"	"13.4"	"5.52"	"469.33"	"3.19"	"1"	"1"	"cell organization and biogenesis;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;other cytoplasmic organelle"	"transporter activity"	"Pf01990"	"9296"	"ENSG00000128524"	"ATP6V1F"	"C9J2K4; hsa:9296; Q16864; Q6IBA8"	"Proximal tubule transport"	"Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport"	"6"	"0"	"22.6"	"17.6"	"20.9"	"29.4"	"36.1"	"31.9"	"67.9"	"86.2"	"33.7"	"47.8"	"71.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14008"	"Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3"	"1"	"2"	"3"	"2"	"2032"	"225.4"	"7.80"	"677.73"	"3.17"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf02985, Pf12348"	"9793"	"ENSG00000175216"	"CKAP5"	"hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4"	"4p16.3 copy number variation"	"Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"14"	"0"	"9.2"	"6.4"	"5.4"	"10.7"	"18.8"	"12.6"	"59.2"	"54.7"	"31.7"	"39.3"	"46.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H0G5"	"Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"558"	"66.4"	"8.84"	"418.71"	"3.16"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf09745, Pf20427"	"84081"	"ENSG00000126653"	"NSRP1"	"hsa:84081; Q6FI71; Q9H0G5"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"15.1"	"6.0"	"13.1"	"10.4"	"16.8"	"17.8"	"59.9"	"57.0"	"41.1"	"54.8"	"61.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q00403"	"Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1"	"5"	"1"	"2"	"1"	"316"	"34.8"	"8.35"	"363.90"	"3.15"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00382, Pf08271"	"2959"	"ENSG00000137947"	"GTF2B"	"A8K1A7; hsa:2959; Q00403; Q5JS30"	"Eukaryotic transcription initiation"	"RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation"	"10"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60613"	"Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4"	"8"	"1"	"2"	"1"	"165"	"18.1"	"5.03"	"328.24"	"3.14"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"ER/Golgi"	"other molecular function"	"Pf08806"	"9403"	"ENSG00000183291"	"SELENOF"	"A0A0B4J1S4; hsa:9403; O60613; Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01"	"Selenium metabolism / selenoproteins; Selenium micronutrient network"	""	"2"	"0"	"12.6"	"9.6"	"13.7"	"21.4"	"20.8"	"20.9"	"63.3"	"52.3"	"28.2"	"44.0"	"61.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92620"	"Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1227"	"140.4"	"6.54"	"344.37"	"3.14"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00270, Pf00271, Pf04408, Pf07717"	"9785"	"ENSG00000140829"	"DHX38"	"B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7"	"mRNA processing"	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"5"	"0"	"47.9"	"40.8"	"65.2"	"81.3"	"86.9"	"90.1"	"225.8"	"248.4"	"149.9"	"217.8"	"267.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NHZ8"	"Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1"	"14"	"1"	"2"	"1"	"85"	"9.8"	"6.81"	"377.10"	"3.13"	"1"	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus"	""	"Pf10471"	"246184"	"ENSG00000176386"	"CDC26"	"hsa:246184; Q8NHZ8"	""	"Assembly of the pre-replicative complex; Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects"	"18"	"0"	"29.7"	"17.5"	"30.4"	"42.9"	"44.0"	"36.9"	"121.8"	"110.6"	"81.5"	"110.3"	"111.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZZ3"	"Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1"	"7"	"1"	"1"	"1"	"219"	"24.6"	"4.83"	""	"3.13"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	""	"Pf03357"	"51510"	"ENSG00000086065"	"CHMP5"	"B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323"	"Ferroptosis"	"Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)"	"3"	"0"	"21.4"	"13.9"	"23.6"	"31.7"	"42.0"	"33.9"	"70.6"	"84.3"	"48.4"	"65.2"	"90.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14254"	"Flotillin-2 OS=Homo sapiens OX=9606 GN=FLOT2 PE=1 SV=2"	"3"	"1"	"2"	"1"	"428"	"47.0"	"5.25"	"286.87"	"3.13"	"1"	"1"	"cell adhesion;transport;other biological processes"	"plasma membrane;other membranes;other cytoplasmic organelle;other cell component"	""	"Pf01145"	"2319"	"ENSG00000132589"	"FLOT2"	"hsa:2319; Q14254"	"Angiopoietin-like protein 8 regulatory pathway; Insulin signaling"	"Regulation of necroptotic cell death; RND1 GTPase cycle; RND3 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Synaptic adhesion-like molecules"	"10"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q969Z0"	"FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1"	"3"	"1"	"2"	"1"	"631"	"70.7"	"7.42"	"441.70"	"3.13"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"mitochondrion;other cell component"	""	"Pf06743, Pf08368, Pf08373"	"9238"	"ENSG00000136270"	"TBRG4"	"A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H974"	"Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1"	"5"	"1"	"1"	"1"	"415"	"46.7"	"6.81"	""	"3.12"	""	"1"	"RNA metabolism OR transcription;other metabolic processes"	"other membranes;mitochondrion;other cell component"	"other molecular function"	"Pf01702"	"79691"	"ENSG00000151576"	"QTRT2"	"A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974"	""	"tRNA modification in the nucleus and cytosol"	"1"	"0"	"11.0"	"6.3"	"12.5"	"16.2"	"18.4"	"18.1"	"40.5"	"44.4"	"25.8"	"34.8"	"47.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BQC6"	"Ribosomal protein 63, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL57 PE=1 SV=1"	"13"	"1"	"2"	"1"	"102"	"12.3"	"11.44"	"304.48"	"3.12"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf14978"	"78988"	"ENSG00000173141"	"MRPL57"	"A2A332; hsa:78988; Q9BQC6"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"9.7"	"8.9"	"10.7"	"14.1"	"22.4"	"19.6"	"42.5"	"38.1"	"35.5"	"48.4"	"74.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UPY8"	"Microtubule-associated protein RP/EB family member 3 OS=Homo sapiens OX=9606 GN=MAPRE3 PE=1 SV=1"	"4"	"1"	"2"	"1"	"281"	"32.0"	"5.54"	"317.45"	"3.11"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00307, Pf03271"	"22924"	"ENSG00000084764"	"MAPRE3"	"B7WPK5; hsa:22924; O00265; Q6FHB0; Q6FI15; Q9BZP7; Q9BZP8; Q9UPY8"	""	""	"0"	"0"	"4.2"	"4.6"	"5.0"	"4.1"	"8.5"	"9.6"	"23.1"	"23.8"	"18.8"	"28.4"	"42.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31350"	"Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1"	"5"	"1"	"2"	"1"	"389"	"44.8"	"5.38"	"247.07"	"3.10"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf00268"	"6241"	"ENSG00000171848"	"RRM2"	"B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7"	"Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway"	"Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription"	"8"	"0"	"17.9"	"6.3"	"12.4"	"18.2"	"22.9"	"20.4"	"53.6"	"46.7"	"28.1"	"38.7"	"52.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IWC1"	"MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2"	"2"	"1"	"2"	"1"	"876"	"98.4"	"9.32"	"513.35"	"3.09"	"1"	"1"	"cell organization and biogenesis"	"cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf05672"	"79649"	"ENSG00000129680"	"MAP7D3"	"A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8"	""	""	"0"	"0"	"30.8"	"14.3"	"19.8"	"37.9"	"44.5"	"39.6"	"129.1"	"134.9"	"75.6"	"95.2"	"138.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14923"	"Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3"	"3"	"2"	"3"	"1"	"745"	"81.7"	"6.14"	"693.23"	"3.09"	"2"	"1"	"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00514"	"3728"	"ENSG00000173801"	"JUP"	"hsa:3728; P14923; Q15093; Q15151; Q7L3S5; Q86W21; Q9BWC4; Q9HCX9"	"Arrhythmogenic right ventricular cardiomyopathy; Corticotropin-releasing hormone signaling pathway; Ectoderm differentiation; Ectoderm differentiation; Epithelial to mesenchymal transition in colorectal cancer; Opioid receptor pathways"	"Neutrophil degranulation; Formation of the cornified envelope; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions; RHOH GTPase cycle"	"21"	"0"	"18.7"	"9.0"	"17.2"	"20.4"	"26.5"	"24.2"	"41.5"	"44.2"	"18.8"	"27.5"	"31.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5TBB1"	"Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1"	"3"	"1"	"2"	"1"	"312"	"35.1"	"9.13"	"392.17"	"3.08"	"1"	"1"	"cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	""	"Pf09468, Pf17745"	"79621"	"ENSG00000136104"	"RNASEH2B"	"G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7"	""	""	"0"	"0"	"47.4"	"28.8"	"45.1"	"49.0"	"71.0"	"67.7"	"196.2"	"196.6"	"126.3"	"154.9"	"211.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00541"	"Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"588"	"68.0"	"7.33"	"369.29"	"3.08"	"1"	"1"	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf06732, Pf16589"	"23481"	"ENSG00000100029"	"PES1"	"hsa:23481; O00541; Q6IC29"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"21.5"	"16.0"	"18.0"	"23.0"	"28.9"	"18.8"	"72.3"	"66.2"	"47.0"	"59.1"	"66.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q56P03"	"E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4"	"4"	"1"	"2"	"1"	"285"	"32.7"	"5.12"	"434.69"	"3.08"	"1"	"1"	"other biological processes"	"nucleus;other cell component"	""	"Pf10238"	"55837"	"ENSG00000129518"	"EAPP"	"hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86"	""	""	"0"	"0"	"17.0"	"13.7"	"18.4"	"23.2"	"23.1"	"17.7"	"48.5"	"51.1"	"33.1"	"37.0"	"49.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HCS7"	"Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2"	"1"	"1"	"2"	"1"	"855"	"99.9"	"6.23"	"476.80"	"3.07"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes"	"nucleus;other cell component"	""	"Pf13181"	"56949"	"ENSG00000076924"	"XAB2"	"hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3"	"Rett syndrome causing genes; Nucleotide excision repair in xeroderma pigmentosum"	"mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER"	"7"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z739"	"YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1"	"2"	"1"	"2"	"1"	"585"	"63.8"	"9.04"	"439.77"	"3.07"	"1"	"1"	"cell organization and biogenesis;other biological processes"	"cytosol;other cell component"	"translation activity;nucleic acid binding activity"	"Pf04146"	"253943"	"ENSG00000185728"	"YTHDF3"	"B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739"	""	""	"0"	"0"	"34.8"	"18.3"	"29.5"	"35.0"	"57.5"	"35.4"	"268.4"	"261.2"	"195.8"	"212.4"	"286.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14331"	"Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1"	"9"	"2"	"3"	"2"	"258"	"29.2"	"9.01"	"715.72"	"3.07"	"2"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytoskeleton;nucleus"	"cytoskeletal activity"	"Pf06229"	"2483"	"ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630"	"FRG1"	"A8K775; hsa:2483; Q14331"	""	""	"0"	"0"	"59.0"	"34.4"	"53.8"	"73.6"	"90.0"	"75.5"	"254.9"	"298.2"	"203.8"	"363.0"	"729.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BZI7"	"Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1"	"2"	"2"	"2"	"2"	"483"	"57.7"	"9.48"	"308.81"	"3.06"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity"	"Pf03467"	"65109"	"ENSG00000125351"	"UPF3B"	"D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0"	""	"mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing"	"6"	"0"	"41.5"	"21.7"	"48.5"	"54.8"	"66.8"	"55.6"	"179.6"	"170.8"	"83.1"	"138.4"	"191.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95619"	"YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1"	"8"	"2"	"3"	"2"	"227"	"26.5"	"8.41"	"671.20"	"3.06"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"other membranes;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf03366"	"8089"	"ENSG00000127337"	"YEATS4"	"hsa:8089; O95619; Q9NQD0"	""	"HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors"	"2"	"0"	"79.9"	"47.3"	"87.2"	"156.3"	"183.7"	"145.7"	"411.0"	"377.8"	"181.1"	"236.8"	"445.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96SB3"	"Neurabin-2 OS=Homo sapiens OX=9606 GN=PPP1R9B PE=1 SV=3"	"2"	"2"	"4"	"1"	"817"	"89.3"	"4.97"	"921.26"	"3.05"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function"	"Pf00595, Pf17817"	"84687"	"ENSG00000108819"	"PPP1R9B"	"D3DTX6; hsa:84687; Q8TCR9; Q96SB3"	""	""	"0"	"0"	"34.3"	"23.6"	"44.8"	"56.7"	"69.4"	"52.9"	"130.1"	"130.0"	"64.3"	"97.2"	"118.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30049"	"ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2"	"5"	"1"	"2"	"1"	"168"	"17.5"	"5.49"	"396.05"	"3.05"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity"	"Pf02823"	"513"	"ENSG00000099624"	"ATP5F1D"	"D6W5Y3; hsa:513; P30049; Q6FG90"	"Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation"	"Cristae formation; Formation of ATP by chemiosmotic coupling"	"5"	"0"	"90.7"	"55.5"	"96.3"	"192.0"	"199.2"	"177.2"	"309.5"	"304.9"	"210.1"	"250.0"	"372.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z2W4"	"Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3"	"1"	"1"	"2"	"1"	"902"	"101.4"	"8.40"	"265.29"	"3.04"	"1"	"1"	"stress response;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00644, Pf02825, Pf18606, Pf18633"	"56829"	"ENSG00000105939"	"ZC3HAV1"	"A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7"	""	"Signaling by BRAF and RAF1 fusions"	"1"	"0"	"11.2"	"8.0"	"10.0"	"18.4"	"23.3"	"17.0"	"45.9"	"49.2"	"35.5"	"35.0"	"47.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BTT0"	"Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1"	"4"	"1"	"2"	"1"	"268"	"30.7"	"3.85"	"387.36"	"3.02"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf14580"	"81611"	"ENSG00000143401"	"ANP32E"	"B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0"	""	""	"0"	"0"	"49.4"	"30.3"	"45.1"	"57.4"	"55.0"	"58.9"	"147.5"	"154.3"	"96.7"	"134.7"	"209.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P0DPB6"	"DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1"	"8"	"1"	"2"	"1"	"133"	"15.2"	"5.80"	"237.80"	"3.02"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf13656"	"51082"	"ENSG00000186184"	"POLR1D"	"hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0"	"Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome"	""	"4"	"0"	"30.2"	"20.6"	"20.5"	"36.7"	"42.0"	"35.8"	"86.9"	"101.6"	"89.0"	"135.7"	"178.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95817"	"BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3"	"2"	"1"	"2"	"1"	"575"	"61.6"	"6.95"	"357.94"	"3.02"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00397, Pf02179"	"9531"	"ENSG00000151929"	"BAG3"	"A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120"	"Cell interactions of the pancreatic cancer microenvironment"	"Regulation of HSF1-mediated heat shock response"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HD47"	"Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1"	"7"	"1"	"2"	"1"	"186"	"20.4"	"4.94"	"339.99"	"3.02"	"1"	"1"	"transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf04603"	"29098"	"ENSG00000108961"	"RANGRF"	"D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2"	""	"Phase 0 - rapid depolarisation"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30040"	"Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4"	"4"	"1"	"2"	"1"	"261"	"29.0"	"7.31"	"360.02"	"3.02"	"1"	"1"	"protein metabolism;other metabolic processes;transport;other biological processes"	"ER/Golgi;other cell component"	"other molecular function"	"Pf07749, Pf07912"	"10961"	"ENSG00000089248"	"ERP29"	"C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4"	""	""	"0"	"0"	"28.6"	"22.6"	"28.1"	"39.3"	"53.6"	"43.5"	"81.2"	"73.6"	"63.7"	"89.6"	"156.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P41208"	"Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1"	"8"	"1"	"2"	"1"	"172"	"19.7"	"5.00"	"336.35"	"3.01"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf13499"	"1069"	"ENSG00000147400"	"CETN2"	"B2R4T4; hsa:1069; P41208; Q53XW1"	"Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER"	"13"	"0"	"17.6"	"10.8"	"21.2"	"31.1"	"34.9"	"27.2"	"81.0"	"103.8"	"64.2"	"90.8"	"100.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q67FW5"	"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 OS=Homo sapiens OX=9606 GN=B3GNTL1 PE=2 SV=2"	"3"	"1"	"1"	"1"	"361"	"40.7"	"7.40"	""	"3.01"	""	"1"	""	""	"other molecular function"	"Pf00535"	"146712"	"ENSG00000175711; ENSG00000277033"	"B3GNTL1"	"hsa:146712; Q67FW5; Q6GV30; Q8WUT3"	""	"O-linked glycosylation of mucins"	"1"	"0"	"0.0"	"0.0"	"0.0"	"4.5"	"4.1"	"2.4"	"4.9"	"8.4"	"15.3"	"32.0"	"65.7"	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96FK6"	"WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=2 SV=1"	"3"	"1"	"2"	"1"	"387"	"43.2"	"6.13"	"386.30"	"3.01"	"1"	"1"	"developmental processes"	""	""	"Pf00400"	"112840"	"ENSG00000140006"	"WDR89"	"hsa:112840; Q96FK6"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13371"	"Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3"	"4"	"1"	"2"	"1"	"301"	"34.3"	"4.73"	"370.19"	"3.01"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes"	"cytosol;other cell component"	""	"Pf02114"	"5082"	"ENSG00000136940"	"PDCL"	"hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2"	""	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95182"	"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFA7 PE=1 SV=3"	"8"	"1"	"2"	"1"	"113"	"12.5"	"10.18"	"295.94"	"2.99"	"1"	"1"	"protein metabolism;other metabolic processes;transport"	"other membranes;mitochondrion;translational apparatus"	"transporter activity;other molecular function"	"Pf07347"	"4701"	"ENSG00000267855"	"NDUFA7"	"hsa:4701; O95182"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"5"	"0"	"62.0"	"44.8"	"57.4"	"69.1"	"80.1"	"68.3"	"144.7"	"122.9"	"96.8"	"128.2"	"117.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H8Y8"	"Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3"	"4"	"1"	"2"	"1"	"452"	"47.1"	"4.82"	"314.50"	"2.99"	"1"	"1"	"cell organization and biogenesis;stress response;other biological processes"	"other membranes;ER/Golgi"	""	"Pf04495"	"26003"	"ENSG00000115806"	"GORASP2"	"B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4"	""	"Golgi Cisternae Pericentriolar Stack Reorganization"	"1"	"0"	"35.0"	"27.3"	"43.4"	"43.6"	"63.0"	"64.6"	"107.3"	"92.1"	"63.0"	"94.1"	"148.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15942"	"Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1"	"3"	"1"	"2"	"1"	"572"	"61.2"	"6.67"	"301.77"	"2.99"	"1"	"1"	"cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf00412"	"7791"	"ENSG00000159840; ENSG00000285443"	"ZYX"	"A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4"	"Integrin-mediated cell adhesion; Focal adhesion"	""	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N5I2"	"Arrestin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARRDC1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"433"	"46.0"	"7.02"	"343.07"	"2.99"	"1"	"1"	"protein metabolism;other metabolic processes;transport;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;other cell component"	"other molecular function"	"Pf00339, Pf02752"	"92714"	"ENSG00000197070"	"ARRDC1"	"hsa:92714; Q8N5I2"	""	""	"0"	"0"	"3.0"	"3.3"	"3.7"	"5.2"	"6.0"	"5.5"	"16.4"	"26.9"	"20.1"	"34.5"	"61.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15910"	"Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2"	"2"	"1"	"2"	"1"	"746"	"85.3"	"7.02"	"381.33"	"2.97"	"1"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00856, Pf11616, Pf18118, Pf18264"	"2146"	"ENSG00000106462"	"EZH2"	"B2RAQ1; B3KS30; B7Z1D6; B7Z7L6; hsa:2146; Q15755; Q15910; Q75MG3; Q92857; Q96FI6"	"Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma"	"HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis"	"19"	"0"	"8.3"	"3.3"	"4.4"	"12.1"	"11.3"	"11.6"	"35.4"	"34.0"	"18.0"	"20.9"	"21.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZQ3"	"NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1"	"2"	"1"	"2"	"1"	"722"	"78.9"	"6.38"	"312.77"	"2.97"	"1"	"1"	"cell organization and biogenesis;transport;other biological processes"	"cytosol;cytoskeleton;nucleus"	"cytoskeletal activity;other molecular function"	"Pf00018, Pf09431"	"51517"	"ENSG00000213672"	"NCKIPSD"	"B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8"	""	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62191"	"26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1"	"6"	"2"	"3"	"2"	"440"	"49.2"	"6.21"	"881.85"	"2.96"	"2"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00004, Pf16450, Pf17862"	"5700"	"ENSG00000100764"	"PSMC1"	"B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle"	"64"	"0"	"61.0"	"28.9"	"40.4"	"69.1"	"74.1"	"67.7"	"144.2"	"177.8"	"87.8"	"119.6"	"162.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96CM8"	"Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2"	"2"	"1"	"2"	"1"	"615"	"68.1"	"7.55"	"346.75"	"2.95"	"1"	"1"	"other metabolic processes"	"mitochondrion"	"other molecular function"	"Pf00501, Pf13193"	"80221"	"ENSG00000167107"	"ACSF2"	"B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2"	"Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders"	"Mitochondrial Fatty Acid Beta-Oxidation"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N5M1"	"ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1"	"4"	"1"	"2"	"1"	"289"	"32.8"	"7.09"	"330.41"	"2.95"	"1"	"1"	"cell organization and biogenesis"	"cytosol;mitochondrion;nucleus"	""	"Pf07542"	"91647"	"ENSG00000171953"	"ATPAF2"	"A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1"	"7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation"	""	"2"	"0"	"9.7"	"10.5"	"14.4"	"22.7"	"30.6"	"26.4"	"42.7"	"46.9"	"27.1"	"36.7"	"67.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92576"	"PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3"	"1"	"1"	"1"	"1"	"2039"	"229.3"	"6.96"	""	"2.94"	""	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00628, Pf07500, Pf07744"	"23469"	"ENSG00000118482"	"PHF3"	"A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"O15294"	"UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3"	"1"	"2"	"3"	"2"	"1046"	"116.9"	"6.70"	"588.37"	"2.93"	"2"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00515, Pf13181, Pf13414, Pf13424, Pf13844"	"8473"	"ENSG00000147162"	"OGT"	"hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57"	"Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma"	"UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones"	"8"	"0"	"71.4"	"61.9"	"85.0"	"126.8"	"127.5"	"128.6"	"195.9"	"195.9"	"103.7"	"126.7"	"167.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P17096"	"High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3"	"23"	"2"	"3"	"2"	"107"	"11.7"	"10.32"	"1052.52"	"2.93"	"2"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	""	"3159"	"ENSG00000137309"	"HMGA1"	"hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0"	"Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway"	"Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)"	"13"	"0"	"81.7"	"47.3"	"72.6"	"80.9"	"92.9"	"80.2"	"455.3"	"474.6"	"293.5"	"380.0"	"542.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKS6"	"Protein kinase C and casein kinase substrate in neurons protein 3 OS=Homo sapiens OX=9606 GN=PACSIN3 PE=1 SV=2"	"3"	"1"	"2"	"1"	"424"	"48.5"	"6.18"	"305.98"	"2.93"	"1"	"1"	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00611, Pf14604"	"29763"	"ENSG00000165912"	"PACSIN3"	"A6NH84; hsa:29763; Q9H331; Q9NWV9; Q9UKS6"	""	"Clathrin-mediated endocytosis"	"1"	"0"	"26.7"	"16.7"	"24.1"	"28.2"	"39.6"	"23.8"	"79.5"	"94.6"	"60.0"	"66.6"	"89.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKV8"	"Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3"	"1"	"1"	"2"	"1"	"859"	"97.1"	"9.19"	"367.91"	"2.90"	"1"	"1"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488"	"27161"	"ENSG00000123908"	"AGO2"	"hsa:27161; Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8"	"exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies"	"Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; MAPK6/MAPK4 signaling; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Small interfering RNA (siRNA) biogenesis; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation"	"22"	"0"	"9.3"	"3.0"	"8.1"	"14.2"	"16.0"	"10.1"	"92.2"	"92.2"	"54.4"	"63.6"	"92.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A6NKF1"	"SAC3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAC3D1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"404"	"43.5"	"8.69"	"332.04"	"2.90"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytoskeleton;nucleus;other cell component"	""	"Pf03399"	""	""	"SAC3D1"	"A6NKF1; A8MX08; Q99773"	""	""	"0"	"0"	"25.8"	"26.0"	"25.6"	"40.6"	"48.1"	"55.5"	"94.5"	"77.1"	"61.3"	"54.3"	"78.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86W92"	"Liprin-beta-1 OS=Homo sapiens OX=9606 GN=PPFIBP1 PE=1 SV=2"	"2"	"1"	"1"	"1"	"1011"	"114.0"	"5.55"	""	"2.89"	""	"1"	"cell adhesion;cell organization and biogenesis"	"plasma membrane;other membranes;cytosol;other cell component"	""	"Pf00536, Pf07647"	"8496"	"ENSG00000110841"	"PPFIBP1"	"hsa:8496; O75336; Q86W92; Q86X70; Q9NY03; Q9ULJ0"	""	"Signaling by ALK fusions and activated point mutants; Receptor-type tyrosine-protein phosphatases"	"2"	"0"	"20.4"	"18.8"	"32.6"	"32.3"	"42.6"	"29.5"	"172.0"	"148.7"	"121.7"	"126.5"	"100.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L4I2"	"Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1"	"3"	"2"	"3"	"2"	"434"	"50.5"	"11.33"	"677.62"	"2.89"	"2"	"1"	""	""	""	"Pf15477"	"65117"	"ENSG00000111011"	"RSRC2"	"hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864"	""	""	"0"	"0"	"93.7"	"56.0"	"89.8"	"126.3"	"169.1"	"132.3"	"338.3"	"328.6"	"177.3"	"260.7"	"302.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L9L4"	"MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3"	"5"	"1"	"2"	"1"	"216"	"25.1"	"6.73"	"352.34"	"2.89"	"1"	"1"	"signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf03637"	"92597"	"ENSG00000173542"	"MOB1B"	"B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23"	"Pleural mesothelioma"	"Signaling by Hippo"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95983"	"Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1"	"4"	"1"	"2"	"1"	"291"	"32.8"	"5.34"	"455.82"	"2.89"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01429, Pf14048, Pf16564"	"53615"	"ENSG00000071655"	"MBD3"	"A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4"	"Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome"	"Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation"	"7"	"0"	"32.2"	"22.5"	"29.8"	"52.0"	"58.5"	"44.3"	"102.2"	"95.6"	"49.8"	"82.0"	"91.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H9C1"	"Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1"	"3"	"1"	"2"	"1"	"493"	"57.0"	"7.40"	"322.01"	"2.89"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf04840"	"63894"	"ENSG00000151445"	"VIPAS39"	"B4DPI6; hsa:63894; O95434; Q9H7E1; Q9H9C1; Q9H9I9"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49915"	"GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1"	"2"	"1"	"2"	"1"	"693"	"76.7"	"6.87"	"376.10"	"2.88"	"1"	"1"	"other metabolic processes"	"cytosol"	"other molecular function"	"Pf00117, Pf00958, Pf02540"	"8833"	"ENSG00000163655"	"GMPS"	"A8K639; B4DXV7; F8W720; hsa:8833; P49915"	""	"Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME"	"2"	"0"	"13.9"	"10.9"	"15.5"	"16.7"	"22.8"	"22.8"	"27.9"	"24.6"	"15.7"	"22.3"	"47.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IVD9"	"NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3"	"4"	"1"	"1"	"1"	"361"	"40.8"	"5.25"	""	"2.88"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytoskeleton;other cell component"	"other molecular function"	"Pf04969, Pf14050"	"23386"	"ENSG00000015676"	"NUDCD3"	"hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4"	""	""	"0"	"0"	"7.2"	"2.5"	"5.6"	"8.8"	"10.9"	"8.5"	"17.3"	"14.5"	"11.8"	"17.2"	"21.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6K1"	"DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens OX=9606 GN=DNMT3A PE=1 SV=4"	"2"	"1"	"2"	"1"	"912"	"101.8"	"6.57"	"344.50"	"2.88"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00145, Pf00855, Pf17980"	"1788"	"ENSG00000119772"	"DNMT3A"	"E9PEB8; hsa:1788; Q86TE8; Q86XF5; Q8IZV0; Q8WXU9; Q9Y6K1"	"One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Opioid receptor pathways"	"RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins"	"10"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P55145"	"Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3"	"5"	"1"	"1"	"1"	"182"	"20.7"	"8.69"	""	"2.87"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;cytosol;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf10208, Pf20145"	"7873"	"ENSG00000145050"	"MANF"	"hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4"	"Orexin receptor pathway"	"Platelet degranulation"	"2"	"0"	"21.2"	"9.3"	"21.8"	"29.3"	"29.4"	"26.5"	"68.6"	"71.8"	"53.5"	"103.8"	"240.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P84101"	"Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1"	"14"	"1"	"2"	"1"	"59"	"6.9"	"10.45"	"368.24"	"2.87"	"1"	"1"	"other biological processes"	"cytosol;nucleus"	""	"Pf04419"	"10169"	"ENSG00000140264"	"SERF2"	"A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7"	""	""	"0"	"0"	"133.8"	"38.3"	"72.7"	"90.6"	"131.7"	"98.6"	"599.4"	"655.7"	"190.0"	"261.5"	"790.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07384"	"Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1"	"5"	"2"	"3"	"2"	"714"	"81.8"	"5.67"	"582.89"	"2.87"	"2"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00648, Pf01067, Pf13833"	"823"	"ENSG00000014216"	"CAPN1"	"hsa:823; P07384; Q2TTR0; Q6DHV4"	"Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"	"7"	"0"	"6.3"	"4.6"	"10.4"	"6.7"	"9.8"	"7.4"	"26.9"	"23.0"	"15.5"	"28.8"	"20.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UJX3"	"Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=4"	"5"	"2"	"3"	"2"	"599"	"66.8"	"5.64"	"597.93"	"2.86"	"2"	"1"	""	""	""	"Pf13432"	"51434"	""	"ANAPC7"	"A0A024RBJ3; hsa:51434"	""	""	"0"	"0"	"19.2"	"11.2"	"14.5"	"23.8"	"24.9"	"30.0"	"47.4"	"48.9"	"30.0"	"38.9"	"47.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NTJ3"	"Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1288"	"147.1"	"6.79"	"317.15"	"2.86"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02463, Pf06470"	"10051"	"ENSG00000113810"	"SMC4"	"A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9"	"Ciliary landscape"	"Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes"	"3"	"0"	"15.0"	"11.1"	"16.3"	"21.7"	"30.4"	"23.8"	"145.7"	"144.0"	"68.3"	"103.6"	"109.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14974"	"Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1"	"1"	"1"	"2"	"1"	"1030"	"115.2"	"5.40"	"306.64"	"2.86"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00023, Pf15898"	"4659"	"ENSG00000058272"	"PPP1R12A"	"B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0"	"Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton"	"Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs"	"8"	"0"	"28.0"	"25.6"	"32.1"	"42.6"	"52.6"	"42.0"	"101.9"	"105.5"	"70.5"	"95.4"	"110.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14684"	"Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3"	"1"	"1"	"2"	"1"	"758"	"84.4"	"9.76"	"260.07"	"2.86"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf05997"	"23076"	"ENSG00000160208"	"RRP1B"	"hsa:23076; Q14684; Q8TBZ4"	""	""	"0"	"0"	"13.7"	"9.4"	"11.3"	"13.5"	"16.2"	"13.4"	"53.2"	"51.0"	"32.6"	"41.0"	"47.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31040"	"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2"	"2"	"1"	"2"	"1"	"664"	"72.6"	"7.39"	"335.91"	"2.85"	"1"	"1"	"other metabolic processes;developmental processes"	"other membranes;mitochondrion;nucleus"	"other molecular function"	"Pf00890, Pf02910"	"6389"	"ENSG00000073578"	"SDHA"	"A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5"	"Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)"	"Respiratory electron transport; Citric acid cycle (TCA cycle)"	"9"	"0"	"106.5"	"65.2"	"93.0"	"125.8"	"143.9"	"147.7"	"267.1"	"260.0"	"182.2"	"216.9"	"232.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NU22"	"Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2"	"0"	"2"	"3"	"2"	"5596"	"632.4"	"5.68"	"505.20"	"2.85"	"2"	"1"	"cell organization and biogenesis;transport"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf07728, Pf17865, Pf17867"	"23195"	"ENSG00000112159; ENSG00000288121"	"MDN1"	"hsa:23195; O15019; Q5T794; Q9NU22"	""	""	"0"	"0"	"14.1"	"9.4"	"11.6"	"12.0"	"16.1"	"13.5"	"25.6"	"14.9"	"11.8"	"16.8"	"24.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q06481"	"Amyloid-like protein 2 OS=Homo sapiens OX=9606 GN=APLP2 PE=1 SV=2"	"2"	"1"	"2"	"1"	"763"	"86.9"	"4.79"	"290.44"	"2.85"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;ER/Golgi;nucleus"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00014, Pf02177, Pf10515, Pf12924, Pf12925"	"334"	"ENSG00000084234"	"APLP2"	"B3KXX9; H7BXI4; hsa:334; Q06481; Q13861; Q14594; Q14662; Q71U10; Q7M4L3; Q9BT36"	"Splicing factor NOVA regulated synaptic proteins"	"Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15532"	"Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3"	"3"	"1"	"2"	"1"	"418"	"45.9"	"6.46"	"400.02"	"2.85"	"1"	"1"	"cell organization and biogenesis;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf05030"	"6760"	"ENSG00000141380"	"SS18"	"B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6"	""	""	"0"	"0"	"9.0"	"0.0"	"8.9"	"9.8"	"8.3"	"8.1"	"23.6"	"27.1"	"20.5"	"14.8"	"19.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96BP3"	"Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"646"	"73.5"	"7.15"	"314.11"	"2.85"	"1"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf00160, Pf00400"	"23398"	"ENSG00000113593"	"PPWD1"	"B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"23.6"	"19.0"	"31.5"	"45.9"	"47.6"	"48.5"	"98.5"	"85.5"	"55.2"	"74.3"	"102.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TE54"	"Anion exchange transporter OS=Homo sapiens OX=9606 GN=SLC26A7 PE=2 SV=2"	"4"	"1"	"1"	"1"	"656"	"72.2"	"7.90"	""	"2.84"	""	"1"	"transport"	"plasma membrane;other membranes;other cytoplasmic organelle;other cell component"	"transporter activity"	"Pf00916, Pf01740"	"115111"	"ENSG00000147606"	"SLC26A7"	"hsa:115111; Q24JS8; Q8TE53; Q8TE54; Q96RN2"	""	"Multifunctional anion exchangers"	"1"	"0"	"15.1"	"10.8"	"16.4"	"18.1"	"22.3"	"21.5"	"77.6"	"85.0"	"47.5"	"79.9"	"112.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92734"	"Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2"	"4"	"1"	"2"	"1"	"400"	"43.4"	"5.10"	"345.35"	"2.84"	"1"	"1"	"cell organization and biogenesis;transport"	"cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf00564"	"10342"	"ENSG00000114354"	"TFG"	"D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2"	""	"Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P36915"	"Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2"	"3"	"1"	"2"	"1"	"607"	"68.6"	"5.80"	"335.25"	"2.84"	"1"	"1"	"stress response;signal transduction;other biological processes"	"non-structural extracellular"	"other molecular function"	"Pf01926"	"2794"	"ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986"	"GNL1"	"B0S838; hsa:2794; P36915; Q96CT5"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"Q8TEA8"	"D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2"	"4"	"1"	"1"	"1"	"209"	"23.4"	"8.24"	""	"2.84"	""	"1"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02580"	"92675"	"ENSG00000125821"	"DTD1"	"A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474"	""	""	"0"	"0"	"24.4"	"13.5"	"23.5"	"30.5"	"37.4"	"38.5"	"147.2"	"237.3"	"139.0"	"216.3"	"579.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P43686"	"26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2"	"3"	"1"	"1"	"1"	"418"	"47.3"	"5.21"	""	"2.84"	""	"1"	"protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00004, Pf16450, Pf17862"	"5704"	"ENSG00000013275; ENSG00000281221"	"PSMC4"	"hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease"	"Neddylation; KEAP1-NFE2L2 pathway; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"64"	"0"	"7.8"	"9.6"	"14.6"	"19.1"	"17.9"	"16.7"	"39.7"	"36.4"	"33.3"	"30.0"	"41.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6NUQ4"	"Transmembrane protein 214 OS=Homo sapiens OX=9606 GN=TMEM214 PE=1 SV=2"	"2"	"1"	"2"	"1"	"689"	"77.1"	"9.14"	"393.61"	"2.83"	"1"	"1"	"other biological processes"	"other membranes;cytosol;cytoskeleton;ER/Golgi"	""	"Pf10151"	"54867"	"ENSG00000119777"	"TMEM214"	"A6NNF2; B3KUI9; B5MCD8; D6W547; hsa:54867; Q53SW1; Q69YH4; Q6NUQ4; Q8NC45; Q8WZ37; Q9NXH2"	""	""	"0"	"0"	"32.2"	"23.0"	"29.0"	"41.0"	"43.1"	"43.7"	"91.9"	"87.8"	"45.8"	"66.6"	"96.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IZ83"	"Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2"	"1"	"1"	"2"	"1"	"802"	"85.1"	"6.79"	"350.20"	"2.83"	"1"	"1"	""	""	"other molecular function"	"Pf00171"	"126133"	"ENSG00000161618"	"ALDH16A1"	"B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8"	""	""	"0"	"0"	"10.9"	"14.1"	"14.4"	"22.6"	"20.8"	"24.3"	"33.1"	"32.5"	"23.7"	"24.7"	"34.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12904"	"Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2"	"4"	"1"	"2"	"1"	"312"	"34.3"	"8.43"	"299.60"	"2.83"	"1"	"1"	"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf01588"	"9255"	"ENSG00000164022"	"AIMP1"	"B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9"	"Ciliary landscape"	"Selenoamino acid metabolism; Cytosolic tRNA aminoacylation"	"3"	"0"	"11.3"	"9.3"	"12.2"	"20.5"	"24.8"	"20.3"	"75.2"	"76.5"	"39.4"	"68.7"	"143.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P09669"	"Cytochrome c oxidase subunit 6C OS=Homo sapiens OX=9606 GN=COX6C PE=1 SV=2"	"11"	"1"	"2"	"1"	"75"	"8.8"	"10.39"	"308.45"	"2.83"	"1"	"1"	"other metabolic processes"	"other membranes;mitochondrion"	""	"Pf02937"	"1345"	"ENSG00000164919"	"COX6C"	"B2R4D7; hsa:1345; P09669"	"Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation"	"TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1"	"8"	"0"	"168.7"	"108.0"	"114.1"	"133.4"	"201.1"	"152.1"	"280.6"	"214.2"	"87.8"	"269.1"	"265.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IXQ4"	"GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"340"	"38.1"	"5.41"	"309.00"	"2.82"	"1"	"1"	""	""	""	"Pf12572"	"55425"	"ENSG00000133114"	"GPALPP1"	"A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6"	""	""	"0"	"0"	"44.8"	"20.7"	"35.0"	"45.4"	"65.1"	"51.9"	"266.3"	"261.1"	"122.0"	"149.3"	"227.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P48729"	"Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2"	"9"	"3"	"4"	"3"	"337"	"38.9"	"9.57"	"1014.40"	"2.82"	"3"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"1452"	"ENSG00000113712"	"CSNK1A1"	"D3DQG0; D3DQG1; hsa:1452; P48729; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3"	"Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development"	"Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein"	"32"	"0"	"93.3"	"43.6"	"88.6"	"121.5"	"152.8"	"130.3"	"806.3"	"813.1"	"420.2"	"584.4"	"853.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75962"	"Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2"	"0"	"1"	"2"	"1"	"3097"	"346.7"	"6.37"	"357.04"	"2.82"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;other cell component"	"enzyme regulator activity;kinase activity;other molecular function"	"Pf00018, Pf00069, Pf00169, Pf00435, Pf00621, Pf00650, Pf07679, Pf16609"	"7204"	"ENSG00000038382"	"TRIO"	"D3DTD1; hsa:7204; O75962; Q13458; Q59EQ7; Q6PJC9; Q6ZN05; Q8IWK8"	"Microtubule cytoskeleton regulation; Neural crest cell migration during development; Neural crest cell migration in cancer"	"RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling"	"14"	"0"	"12.6"	"15.6"	"11.3"	"9.6"	"15.3"	"17.4"	"42.5"	"56.9"	"64.8"	"73.8"	"66.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NCA5"	"Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2"	"4"	"1"	"1"	"1"	"518"	"55.2"	"8.95"	""	"2.82"	""	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf10239"	"25940"	"ENSG00000119812"	"FAM98A"	"B2RNA2; hsa:25940; Q8NCA5; Q9Y3Y6"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99543"	"DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4"	"3"	"1"	"2"	"1"	"621"	"72.0"	"8.70"	"367.27"	"2.81"	"1"	"1"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes"	"other membranes;cytosol;nucleus;other cell component"	"translation activity;other molecular function"	"Pf00226, Pf00249, Pf16717"	"27000"	"ENSG00000105821"	"DNAJC2"	"A4VCI0; hsa:27000; Q99543; Q9BVX1"	""	"Regulation of HSF1-mediated heat shock response"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"Q9H7N4"	"Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3"	"1"	"1"	"2"	"1"	"1312"	"139.2"	"9.25"	"333.58"	"2.81"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	""	"58506"	"ENSG00000126461"	"SCAF1"	"hsa:58506; Q7Z5V7; Q8WVA1; Q9H7N4; Q9NR59"	""	""	"0"	"0"	"16.4"	"13.6"	"14.4"	"19.9"	"31.3"	"19.5"	"60.4"	"42.5"	"27.4"	"43.7"	"36.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82663"	"28S ribosomal protein S25, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1"	"7"	"1"	"2"	"1"	"173"	"20.1"	"8.82"	"276.09"	"2.81"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf05047"	"64432"	"ENSG00000131368"	"MRPS25"	"B4DFJ5; B4DQG6; hsa:64432; P82663; Q9H7P5"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"16.5"	"15.8"	"10.1"	"21.5"	"23.7"	"25.3"	"32.4"	"27.2"	"20.5"	"22.1"	"44.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75608"	"Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"230"	"24.7"	"6.77"	"365.04"	"2.80"	"1"	"1"	"protein metabolism;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf02230"	"10434"	"ENSG00000120992"	"LYPLA1"	"hsa:10434; O43202; O75608; Q9UQF9"	""	"RAS processing; eNOS activation"	"2"	"0"	"87.9"	"51.0"	"72.2"	"133.8"	"182.3"	"146.1"	"224.2"	"217.5"	"150.9"	"153.9"	"247.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BYD3"	"39S ribosomal protein L4, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1"	"4"	"1"	"2"	"1"	"311"	"34.9"	"9.72"	"271.85"	"2.80"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf00573"	"51073"	"ENSG00000105364"	"MRPL4"	"A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"5.2"	"6.7"	"6.8"	"11.7"	"12.2"	"11.8"	"26.2"	"23.5"	"18.5"	"15.1"	"23.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23526"	"Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4"	"3"	"1"	"2"	"1"	"432"	"47.7"	"6.34"	"360.24"	"2.80"	"1"	"1"	"other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf00670, Pf05221"	"191"	"ENSG00000101444"	"AHCY"	"A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36"	"Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications"	"Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD"	"10"	"0"	"27.6"	"18.6"	"27.9"	"23.8"	"40.2"	"51.9"	"48.6"	"36.0"	"30.3"	"51.3"	"85.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86X29"	"Lipolysis-stimulated lipoprotein receptor OS=Homo sapiens OX=9606 GN=LSR PE=1 SV=4"	"2"	"1"	"1"	"1"	"649"	"71.4"	"7.97"	""	"2.79"	""	"1"	"cell organization and biogenesis;developmental processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;other cell component"	""	"Pf05624"	"51599"	"ENSG00000105699"	"LSR"	"A6NDW3; B4DKL4; E9PHD4; hsa:51599; O00112; O00426; Q6ZT80; Q86X29; Q8NBM0; Q9BT33; Q9UQL3"	""	"LDL clearance; VLDL clearance"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3B9"	"RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2"	"6"	"2"	"3"	"2"	"282"	"31.5"	"5.52"	"587.60"	"2.79"	"2"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"other cell component"	""	"Pf07890"	"51018"	"ENSG00000067533"	"RRP15"	"hsa:51018; Q9Y3B9"	""	""	"0"	"0"	"28.8"	"23.1"	"29.9"	"45.0"	"59.8"	"56.8"	"155.5"	"136.4"	"81.2"	"113.2"	"119.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P42766"	"60S ribosomal protein L35 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2"	"18"	"3"	"3"	"2"	"123"	"14.5"	"11.05"	"541.81"	"2.79"	"2"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00831"	"11224"	"ENSG00000136942"	"RPL35"	"A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4"	"Cytoplasmic ribosomal proteins"	"Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"178.6"	"112.0"	"183.1"	"223.4"	"254.6"	"230.6"	"961.7"	"846.4"	"466.9"	"659.1"	"851.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6M9"	"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Homo sapiens OX=9606 GN=NDUFB9 PE=1 SV=3"	"12"	"2"	"3"	"2"	"179"	"21.8"	"8.38"	"769.20"	"2.79"	"2"	"1"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity"	"Pf05347"	"4715"	"ENSG00000147684"	"NDUFB9"	"B2R8M6; hsa:4715; Q9UQE8; Q9Y6M9"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation"	"Complex I biogenesis"	"6"	"0"	"8.1"	"12.2"	"13.8"	"13.6"	"20.3"	"20.6"	"42.7"	"36.0"	"27.3"	"29.5"	"43.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02790"	"Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3"	"5"	"3"	"5"	"3"	"459"	"51.8"	"5.43"	"1076.96"	"2.78"	"3"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00254, Pf00515"	"2288"	"ENSG00000004478"	"FKBP4"	"D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7"	"Androgen receptor signaling pathway"	"Estrogen-dependent gene expression; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Potential therapeutics for SARS; Attenuation phase"	"6"	"0"	"211.1"	"131.5"	"184.2"	"232.8"	"326.3"	"299.3"	"553.6"	"499.4"	"292.7"	"461.1"	"836.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50579"	"Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1"	"4"	"1"	"2"	"1"	"478"	"52.9"	"5.82"	"286.83"	"2.78"	"1"	"1"	"protein metabolism;other metabolic processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf00557"	"10988"	"ENSG00000111142"	"METAP2"	"B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11"	""	"Inactivation, recovery and regulation of the phototransduction cascade"	"1"	"0"	"6.0"	"0.0"	"4.3"	"7.4"	"9.5"	"7.3"	"29.5"	"31.4"	"9.9"	"21.6"	"37.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14966"	"Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2"	"1"	"2"	"3"	"2"	"1978"	"220.5"	"6.38"	"497.51"	"2.77"	"2"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00076, Pf12171"	"27332"	"ENSG00000075292"	"ZNF638"	"A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37"	""	"Transcriptional regulation of white adipocyte differentiation"	"1"	"0"	"17.8"	"13.2"	"20.2"	"29.9"	"35.6"	"31.1"	"105.2"	"89.1"	"51.9"	"74.7"	"107.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P36507"	"Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1"	"2"	"1"	"2"	"1"	"400"	"44.4"	"6.55"	"252.69"	"2.77"	"1"	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;kinase activity;other molecular function"	"Pf00069"	"5605"	"ENSG00000126934"	"MAP2K2"	"hsa:5605; P36507"	"IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; A network map of Macrophage-stimulating protein (MSP) signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway"	"Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants"	"83"	"0"	"8.9"	"7.5"	"9.9"	"7.0"	"13.7"	"13.0"	"22.8"	"22.1"	"14.5"	"18.3"	"27.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46778"	"60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2"	"9"	"2"	"3"	"2"	"160"	"18.6"	"10.49"	"683.77"	"2.77"	"2"	"1"	"protein metabolism;other metabolic processes"	"cytosol;ER/Golgi;translational apparatus;other cell component"	"other molecular function"	"Pf01157"	"6144"	"ENSG00000122026"	"RPL21"	"hsa:6144; P46778; Q16699"	"Cytoplasmic ribosomal proteins"	"SRP-dependent cotranslational protein targeting to membrane; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"	"14"	"0"	"216.4"	"112.9"	"181.0"	"195.8"	"255.2"	"231.8"	"1284.1"	"1106.5"	"742.2"	"953.5"	"1106.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P16278"	"Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"677"	"76.0"	"6.57"	"314.05"	"2.77"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf01301, Pf13364"	"2720"	"ENSG00000170266"	"GLB1"	"B2R7H8; B7Z6B0; hsa:2720; P16278; P16279"	"Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence"	"Neutrophil degranulation; Glycosphingolipid metabolism; HS-GAG degradation; Sialic acid metabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B"	"12"	"0"	"15.7"	"11.1"	"19.9"	"25.6"	"24.9"	"21.9"	"32.2"	"37.6"	"22.5"	"33.9"	"48.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BV57"	"1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1"	"11"	"2"	"3"	"2"	"179"	"21.5"	"5.68"	"519.20"	"2.77"	"2"	"1"	"other metabolic processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf03079"	"55256"	"ENSG00000182551"	"ADI1"	"D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57"	"Methionine de novo and salvage pathway"	"Methionine salvage pathway"	"2"	"0"	"51.8"	"32.9"	"47.0"	"52.3"	"78.5"	"68.4"	"126.6"	"129.5"	"96.7"	"118.0"	"163.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H9J2"	"39S ribosomal protein L44, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1"	"2"	"1"	"2"	"1"	"332"	"37.5"	"8.40"	"334.51"	"2.76"	"1"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus"	"nucleic acid binding activity;other molecular function"	""	"65080"	"ENSG00000135900"	"MRPL44"	"hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"91.3"	"62.5"	"81.8"	"116.9"	"149.5"	"130.0"	"285.2"	"304.5"	"177.1"	"265.7"	"442.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94887"	"FERM, ARHGEF and pleckstrin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FARP2 PE=1 SV=3"	"1"	"1"	"2"	"1"	"1054"	"119.8"	"8.79"	"272.68"	"2.76"	"1"	"1"	"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;other cell component"	"enzyme regulator activity;cytoskeletal activity"	"Pf00169, Pf00373, Pf00621, Pf08736, Pf09379, Pf09380"	"9855"	"ENSG00000006607"	"FARP2"	"B7Z6J8; F5GZ84; hsa:9855; O94887; Q53QM5; Q8WU27; Q9UFE7"	"2q37 copy number variation syndrome; TAR syndrome"	"RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"	"4"	"0"	"42.6"	"30.3"	"48.1"	"54.0"	"75.8"	"70.6"	"203.9"	"195.8"	"140.2"	"185.6"	"255.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92504"	"Zinc transporter SLC39A7 OS=Homo sapiens OX=9606 GN=SLC39A7 PE=1 SV=2"	"3"	"1"	"2"	"1"	"469"	"50.1"	"6.87"	"316.67"	"2.76"	"1"	"1"	"transport;other biological processes"	"other membranes;ER/Golgi;nucleus"	"transporter activity"	"Pf02535"	"7922"	"ENSG00000112473; ENSG00000206288; ENSG00000224399; ENSG00000226614; ENSG00000227402; ENSG00000229802"	"SLC39A7"	"B0UXF6; hsa:7922; Q5STP8; Q92504; Q9UIQ0"	"Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis"	"Zinc influx into cells by the SLC39 gene family"	"4"	"0"	"21.5"	"5.2"	"22.0"	"23.2"	"30.1"	"29.9"	"79.7"	"56.3"	"24.0"	"48.7"	"64.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5UIP0"	"Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2"	"1"	"1"	"2"	"1"	"2472"	"274.3"	"5.52"	"256.41"	"2.75"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytoskeleton;nucleus;other cell component"	""	"Pf12231"	"55183"	"ENSG00000080345"	"RIF1"	"A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4"	"ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome"	"Nonhomologous End-Joining (NHEJ)"	"3"	"0"	"21.2"	"18.1"	"26.7"	"36.2"	"47.9"	"38.7"	"89.1"	"78.8"	"52.4"	"73.5"	"87.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82970"	"High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1"	"9"	"2"	"3"	"2"	"282"	"31.5"	"4.55"	"607.36"	"2.75"	"2"	"1"	"cell organization and biogenesis;other biological processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01101"	"79366"	"ENSG00000198157"	"HMGN5"	"hsa:79366; P82970; Q5JSL1"	""	""	"0"	"0"	"84.9"	"46.9"	"81.8"	"91.9"	"112.4"	"122.0"	"272.2"	"273.9"	"166.5"	"277.1"	"369.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35241"	"Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1"	"3"	"2"	"3"	"1"	"583"	"68.5"	"6.37"	"664.40"	"2.75"	"2"	"1"	"cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00373, Pf00769, Pf09379, Pf09380, Pf20492"	"5962"	"ENSG00000137710"	"RDX"	"A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61"	"Regulation of actin cytoskeleton"	"Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea"	"4"	"0"	"3.6"	"3.0"	"7.4"	"6.5"	"15.8"	"13.4"	"51.1"	"40.8"	"28.6"	"53.3"	"83.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62312"	"U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1"	"10"	"1"	"2"	"1"	"80"	"9.1"	"9.58"	"305.83"	"2.74"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf01423"	"11157"	"ENSG00000164167"	"LSM6"	"hsa:11157; P62312; Q4W5J5; Q9Y4Y8"	""	"mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease"	"2"	"0"	"190.0"	"115.5"	"147.1"	"169.3"	"241.1"	"206.0"	"563.1"	"513.4"	"322.4"	"446.3"	"647.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UJX2"	"Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3"	"2"	"1"	"2"	"1"	"597"	"68.8"	"7.02"	"307.90"	"2.73"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus"	"other molecular function"	"Pf04049"	"8697"	"ENSG00000094880"	"CDC23"	"A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2"	"Cell cycle"	"Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects"	"19"	"0"	"17.9"	"14.8"	"18.2"	"26.1"	"26.4"	"24.4"	"55.8"	"62.2"	"41.5"	"51.4"	"68.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q08209"	"Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1"	"2"	"1"	"2"	"1"	"521"	"58.7"	"5.86"	"341.51"	"2.73"	"1"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00149"	"5530"	"ENSG00000138814"	"PPP3CA"	"A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9"	"Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway"	"DARPP-32 events; FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT"	"25"	"0"	"40.3"	"37.4"	"52.0"	"74.2"	"93.6"	"90.1"	"125.5"	"126.4"	"102.6"	"126.1"	"125.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16851"	"UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5"	"2"	"1"	"2"	"1"	"508"	"56.9"	"8.15"	"300.14"	"2.73"	"1"	"1"	"other metabolic processes;developmental processes"	"cytosol;other cell component"	"other molecular function"	"Pf01704"	"7360"	"ENSG00000169764"	"UGP2"	"hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15"	"Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation"	"Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate"	"5"	"0"	"39.1"	"29.6"	"35.9"	"53.4"	"62.5"	"55.6"	"106.1"	"109.6"	"62.8"	"94.9"	"113.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92558"	"Wiskott-Aldrich syndrome protein family member 1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1"	"2"	"1"	"1"	"1"	"559"	"61.6"	"6.46"	""	"2.73"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;mitochondrion;other cell component"	"cytoskeletal activity;other molecular function"	"Pf02205"	"8936"	"ENSG00000112290"	"WASF1"	"E1P5F2; hsa:8936; Q5SZK7; Q92558"	"VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton"	"VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle"	"8"	"0"	"4.1"	"3.2"	"8.1"	"7.0"	"9.1"	"9.9"	"35.1"	"24.4"	"19.8"	"31.3"	"33.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86X55"	"Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3"	"2"	"1"	"2"	"1"	"608"	"65.8"	"6.73"	"259.15"	"2.73"	"1"	"1"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf06325, Pf11531"	"10498"	"ENSG00000142453"	"CARM1"	"A6NN38; hsa:10498; Q86X55"	"Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis"	"Estrogen-dependent gene expression; PPARA activates gene expression; RMTs methylate histone arginines; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression"	"15"	"0"	"6.8"	"9.0"	"12.3"	"23.2"	"30.2"	"25.0"	"31.4"	"33.3"	"16.9"	"27.7"	"35.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NQ50"	"39S ribosomal protein L40, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1"	"7"	"1"	"2"	"1"	"206"	"24.5"	"9.63"	"434.78"	"2.72"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	""	"Pf09812"	"64976"	"ENSG00000185608"	"MRPL40"	"B3KVZ7; hsa:64976; O95134; Q9NQ50"	"22q11.2 copy number variation syndrome"	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15091"	"Mitochondrial ribonuclease P catalytic subunit OS=Homo sapiens OX=9606 GN=PRORP PE=1 SV=2"	"3"	"1"	"2"	"1"	"583"	"67.3"	"8.78"	"313.71"	"2.72"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"mitochondrion;nucleus"	"other molecular function"	"Pf16953"	"9692"	"ENSG00000100890"	"PRORP"	"B4DXD9; B4E0S8; B4E211; C4AM93; D3DS99; D3DSA1; hsa:9692; O15091; Q86SZ4; Q86YB5; Q8N5L5"	""	"tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q53H12"	"Acylglycerol kinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGK PE=1 SV=2"	"3"	"1"	"2"	"1"	"422"	"47.1"	"8.09"	"278.40"	"2.70"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;transport"	"other membranes;cytosol;mitochondrion;other cell component"	"kinase activity;other molecular function"	"Pf00781, Pf19712"	"55750"	"ENSG00000006530; ENSG00000262327"	"AGK"	"hsa:55750; Q53H12; Q75KN1; Q96GC3; Q9NP48"	""	"Signaling by BRAF and RAF1 fusions; Glycerophospholipid biosynthesis"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96HP4"	"Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1"	"6"	"1"	"2"	"1"	"312"	"34.8"	"8.37"	"344.34"	"2.70"	"1"	"1"	""	""	"other molecular function"	"Pf00175"	"92106"	"ENSG00000154814"	"OXNAD1"	"hsa:92106; Q2HYC7; Q59FA4; Q96HP4"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TAE8"	"Growth arrest and DNA damage-inducible proteins-interacting protein 1 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1"	"5"	"1"	"2"	"1"	"222"	"25.4"	"10.02"	"301.71"	"2.70"	"1"	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	""	"Pf10147"	"90480"	"ENSG00000179271"	"GADD45GIP1"	"hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"10.4"	"7.7"	"8.0"	"13.7"	"17.9"	"19.1"	"44.0"	"51.5"	"35.7"	"56.9"	"72.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O15541"	"E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1"	"3"	"1"	"2"	"1"	"343"	"38.8"	"5.69"	"296.68"	"2.70"	"1"	"1"	"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"nucleus"	"other molecular function"	"Pf00642, Pf13920"	"7737"	"ENSG00000125352"	"RNF113A"	"B2RBR7; hsa:7737; O15541"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"13.4"	"11.5"	"15.8"	"18.5"	"23.8"	"19.3"	"47.3"	"35.6"	"28.0"	"50.1"	"66.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16795"	"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA9 PE=1 SV=2"	"3"	"1"	"2"	"1"	"377"	"42.5"	"9.80"	"323.52"	"2.70"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf01370"	"4704"	"ENSG00000139180"	"NDUFA9"	"hsa:4704; Q14076; Q16795; Q2NKX0"	"Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"6"	"0"	"25.6"	"14.8"	"24.8"	"31.0"	"36.8"	"28.5"	"68.1"	"76.1"	"38.7"	"61.0"	"71.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NR12"	"PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1"	"2"	"1"	"2"	"1"	"457"	"49.8"	"8.41"	"350.56"	"2.70"	"1"	"1"	"cell organization and biogenesis;transport;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00412, Pf00595"	"9260"	"ENSG00000196923"	"PDLIM7"	"hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12"	"Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation"	"RET signaling"	"4"	"0"	"23.6"	"15.7"	"21.7"	"42.0"	"45.8"	"36.0"	"153.8"	"156.6"	"96.1"	"118.1"	"171.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRA2"	"Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1"	"7"	"1"	"2"	"1"	"123"	"13.9"	"5.52"	"364.60"	"2.70"	"1"	"1"	"signal transduction;other biological processes"	"cytosol"	"other molecular function"	"Pf06110"	"84817"	"ENSG00000129235"	"TXNDC17"	"A8K7E8; hsa:84817; Q9BRA2"	""	""	"0"	"0"	"23.7"	"17.2"	"21.0"	"28.0"	"37.0"	"38.4"	"70.1"	"53.5"	"29.8"	"55.2"	"114.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9ULW0"	"Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2"	"2"	"1"	"2"	"1"	"747"	"85.6"	"9.23"	"341.13"	"2.69"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf06886, Pf09041, Pf12214"	"22974"	"ENSG00000088325"	"TPX2"	"hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1"	"Gastric cancer network 1"	"Regulation of TP53 Activity through Phosphorylation; AURKA Activation by TPX2"	"3"	"0"	"11.8"	"8.1"	"16.8"	"15.6"	"26.0"	"21.3"	"55.3"	"57.6"	"30.4"	"48.6"	"54.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75688"	"Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1"	"2"	"1"	"2"	"1"	"479"	"52.6"	"5.05"	"356.01"	"2.69"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"other membranes;cytosol;nucleus"	"other molecular function"	"Pf00481, Pf07830"	"5495"	"ENSG00000138032"	"PPM1B"	"hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8"	"MAPK signaling pathway"	"ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants"	"4"	"0"	"18.4"	"9.9"	"15.7"	"32.4"	"32.9"	"30.8"	"52.8"	"47.0"	"36.7"	"42.0"	"42.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P29144"	"Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4"	"1"	"1"	"1"	"1"	"1249"	"138.3"	"6.32"	""	"2.69"	""	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00082, Pf12580"	"7174"	"ENSG00000134900"	"TPP2"	"hsa:7174; P29144; Q5VZU8"	""	"Antigen processing: Ubiquitination & Proteasome degradation"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14739"	"Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2"	"1"	"1"	"2"	"1"	"615"	"70.7"	"9.36"	"279.56"	"2.68"	"1"	"1"	"other metabolic processes;other biological processes"	"other membranes;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01222, Pf09465"	"3930"	"ENSG00000143815"	"LBR"	"B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6"	"Gastric cancer network 2; ATM signaling in development and disease ; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism"	"RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; RHOG GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Cholesterol biosynthesis"	"19"	"0"	"61.4"	"53.9"	"64.8"	"85.0"	"102.9"	"76.4"	"278.9"	"263.1"	"136.1"	"198.3"	"224.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96I59"	"Probable asparagine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3"	"2"	"1"	"2"	"1"	"477"	"54.1"	"7.24"	"281.43"	"2.68"	"1"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol;mitochondrion;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00152, Pf01336"	"79731"	"ENSG00000137513"	"NARS2"	"G3V178; hsa:79731; Q96I59"	"Ectoderm differentiation"	"Mitochondrial tRNA aminoacylation"	"2"	"0"	"55.7"	"26.7"	"38.5"	"67.2"	"89.1"	"66.9"	"164.7"	"160.5"	"80.0"	"122.1"	"187.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BR76"	"Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1"	"2"	"1"	"2"	"1"	"489"	"54.2"	"5.88"	"304.41"	"2.67"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00400, Pf08953, Pf16300"	"57175"	"ENSG00000172725"	"CORO1B"	"B2RD45; hsa:57175; Q9BR76"	""	""	"0"	"0"	"19.1"	"10.6"	"15.2"	"18.4"	"21.4"	"15.4"	"58.7"	"50.7"	"30.8"	"51.5"	"73.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5VTL8"	"Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1"	"1"	"1"	"2"	"1"	"546"	"64.4"	"10.54"	"310.43"	"2.67"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf03371"	"55119"	"ENSG00000134186"	"PRPF38B"	"hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40"	""	""	"0"	"0"	"98.1"	"61.7"	"89.1"	"105.6"	"150.5"	"127.0"	"335.8"	"317.7"	"182.8"	"335.0"	"474.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P33316"	"Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4"	"5"	"1"	"2"	"1"	"252"	"26.5"	"9.36"	"333.34"	"2.67"	"1"	"1"	"DNA metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;mitochondrion;nucleus"	"signal transduction activity or receptor binding;other molecular function"	"Pf00692"	"1854"	"ENSG00000128951"	"DUT"	"A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81"	"Pyrimidine metabolism"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96F85"	"CB1 cannabinoid receptor-interacting protein 1 OS=Homo sapiens OX=9606 GN=CNRIP1 PE=1 SV=1"	"5"	"1"	"1"	"1"	"164"	"18.6"	"7.94"	""	"2.67"	""	"1"	"other biological processes"	"plasma membrane;other membranes;other cell component"	"signal transduction activity or receptor binding"	"Pf15043"	"25927"	"ENSG00000119865"	"CNRIP1"	"B2R4D0; hsa:25927; Q49AN4; Q96F85; Q9UFZ0"	""	""	"0"	"0"	"26.8"	"17.7"	"24.8"	"31.9"	"36.1"	"33.1"	"72.5"	"94.0"	"180.4"	"336.8"	"519.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12959"	"Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"904"	"100.4"	"5.76"	"309.45"	"2.66"	"1"	"1"	"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes"	"extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"cytoskeletal activity;kinase activity;other molecular function"	"Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608"	"1739"	"ENSG00000075711"	"DLG1"	"A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959"	"Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome"	"Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor"	"14"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TEW0"	"Partitioning defective 3 homolog OS=Homo sapiens OX=9606 GN=PARD3 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1356"	"151.3"	"7.68"	"297.38"	"2.66"	"1"	"1"	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00595, Pf12053"	"56288"	"ENSG00000148498"	"PARD3"	"F5H5T0; hsa:56288; Q5T2U1; Q5VUA2; Q5VUA3; Q5VWV0; Q5VWV1; Q5VWV3; Q5VWV4; Q5VWV5; Q6IQ47; Q8TCZ9; Q8TEW0; Q8TEW1; Q8TEW2; Q8TEW3; Q96K28; Q96RM6; Q96RM7; Q9BY57; Q9BY58; Q9HC48; Q9NWL4; Q9NYE6"	"Chemokine signaling pathway; Complement system in neuronal development and plasticity"	"Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"	"4"	"0"	"8.7"	"6.2"	"9.4"	"12.3"	"12.5"	"12.3"	"33.8"	"33.2"	"20.5"	"31.7"	"43.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P11766"	"Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4"	"2"	"1"	"2"	"1"	"374"	"39.7"	"7.49"	"306.80"	"2.65"	"1"	"1"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion"	"other molecular function"	"Pf00107, Pf08240"	"128"	"ENSG00000197894"	"ADH5"	"hsa:128; P11766; Q6FHR2"	"Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism"	"Ethanol oxidation"	"3"	"0"	"71.0"	"53.1"	"74.9"	"97.9"	"127.8"	"129.5"	"187.4"	"185.7"	"109.0"	"162.7"	"225.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BUL8"	"Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1"	"5"	"1"	"2"	"1"	"212"	"24.7"	"8.19"	"317.97"	"2.64"	"1"	"1"	"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf06840"	"11235"	"ENSG00000114209"	"PDCD10"	"A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8"	""	""	"0"	"0"	"43.7"	"31.0"	"40.5"	"62.3"	"64.3"	"64.8"	"281.4"	"247.5"	"175.5"	"202.6"	"213.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43847"	"Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3"	"1"	"1"	"2"	"1"	"1151"	"131.6"	"4.98"	"329.39"	"2.63"	"1"	"1"	"protein metabolism;other biological processes"	"cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00675, Pf05193, Pf16187"	"4898"	"ENSG00000078618"	"NRDC"	"A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5T9A4"	"ATPase family AAA domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ATAD3B PE=1 SV=1"	"2"	"1"	"2"	"1"	"648"	"72.5"	"9.20"	"272.35"	"2.63"	"1"	"1"	"cell organization and biogenesis"	"plasma membrane;other membranes;mitochondrion"	"other molecular function"	"Pf00004, Pf12037"	"83858"	"ENSG00000160072"	"ATAD3B"	"A8K3H1; hsa:83858; Q5T9A4; Q6ZRB5; Q9BUK4; Q9ULE7"	"1p36 copy number variation syndrome"	"Neutrophil degranulation"	"2"	"0"	"14.6"	"13.0"	"10.8"	"15.9"	"23.6"	"15.8"	"36.4"	"26.0"	"23.0"	"34.5"	"33.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6NYC1"	"Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1"	"3"	"1"	"2"	"1"	"403"	"46.4"	"8.69"	"259.12"	"2.63"	"1"	"1"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02373"	"23210"	"ENSG00000070495"	"JMJD6"	"B3KMN8; B4DGX1; hsa:23210; Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2"	""	"HDMs demethylate histones"	"1"	"0"	"6.8"	"0.0"	"7.9"	"7.6"	"17.5"	"15.4"	"67.6"	"73.0"	"22.6"	"32.0"	"30.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NP81"	"Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1"	"4"	"2"	"3"	"2"	"518"	"58.2"	"8.13"	"518.76"	"2.63"	"2"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"mitochondrion"	"nucleic acid binding activity;other molecular function"	"Pf00587"	"54938"	"ENSG00000104835; ENSG00000283104"	"SARS2"	"A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81"	""	"Mitochondrial tRNA aminoacylation"	"1"	"0"	"12.6"	"6.2"	"10.9"	"15.0"	"21.8"	"17.5"	"39.5"	"41.0"	"23.2"	"30.1"	"42.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y296"	"Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1"	"9"	"2"	"3"	"2"	"219"	"24.3"	"6.21"	"577.77"	"2.62"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component"	""	"Pf04099"	"51399"	"ENSG00000196655; ENSG00000280495"	"TRAPPC4"	"A8K3A5; B4DME1; hsa:51399; Q9Y296"	""	"RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions"	"3"	"0"	"53.4"	"53.6"	"68.1"	"80.3"	"93.2"	"86.6"	"124.8"	"116.0"	"79.5"	"116.6"	"153.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6IQ22"	"Ras-related protein Rab-12 OS=Homo sapiens OX=9606 GN=RAB12 PE=1 SV=3"	"5"	"1"	"2"	"1"	"244"	"27.2"	"8.41"	"382.79"	"2.62"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle"	"other molecular function"	"Pf00071"	"201475"	""	"RAB12"	"A6NEF5; hsa:201475; Q4KMQ3; Q6IQ22"	""	"RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs"	"2"	"0"	"45.8"	"40.2"	"37.8"	"45.2"	"73.6"	"61.6"	"106.9"	"100.5"	"58.9"	"103.7"	"153.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14696"	"LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2"	"5"	"1"	"2"	"1"	"234"	"26.1"	"7.78"	"420.28"	"2.61"	"1"	"1"	"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;ER/Golgi"	"signal transduction activity or receptor binding;other molecular function"	"Pf10185"	"23184"	"ENSG00000117899"	"MESD"	"B4DW84; D3DW96; hsa:23184; Q14696; Q969U1"	""	""	"0"	"0"	"128.6"	"49.7"	"112.2"	"182.3"	"244.1"	"222.1"	"399.2"	"428.7"	"310.3"	"374.8"	"832.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86WR0"	"Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2"	"5"	"1"	"2"	"1"	"208"	"24.5"	"6.80"	"267.02"	"2.61"	"1"	"1"	"other biological processes"	"plasma membrane;other membranes;other cell component"	"nucleic acid binding activity"	"Pf05670"	"55246"	"ENSG00000147419"	"CCDC25"	"hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P47756"	"F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4"	"5"	"1"	"2"	"1"	"277"	"31.3"	"5.59"	"323.05"	"2.61"	"1"	"1"	"cell organization and biogenesis"	"cytoskeleton;other cell component"	"cytoskeletal activity"	"Pf01115"	"100612860; 101140941"	"ENSGGOG00000003982; ENSPPYG00000001789; ENSPTRG00000000268"	"CAPZB"	"A0A2J8KEQ9; A0A2J8T2J3; A0A6D2W7V0; A0A6D2XKL1; A0A8B6ZIG4; A0A9B0TL78; G3QN07; H2N8T0; H2R9E0"	""	""	"0"	"0"	"28.8"	"15.7"	"29.7"	"35.5"	"45.3"	"35.1"	"122.3"	"115.6"	"77.6"	"91.8"	"99.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UJZ1"	"Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1"	"3"	"1"	"2"	"1"	"356"	"38.5"	"7.39"	"338.99"	"2.60"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytoskeleton;mitochondrion"	"signal transduction activity or receptor binding;other molecular function"	"Pf01145, Pf16200"	"30968"	"ENSG00000165283"	"STOML2"	"B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1"	""	"Processing of SMDT1"	"1"	"0"	"10.2"	"5.5"	"8.7"	"8.9"	"14.8"	"10.8"	"30.8"	"33.6"	"20.0"	"29.0"	"30.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30044"	"Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4"	"4"	"1"	"2"	"1"	"214"	"22.1"	"8.70"	"335.47"	"2.59"	"1"	"1"	"other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf08534"	"25824"	"ENSG00000126432"	"PRDX5"	"A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4"	"Selenium micronutrient network"	""	"1"	"0"	"86.1"	"51.7"	"75.7"	"104.5"	"114.6"	"123.9"	"187.2"	"172.4"	"113.3"	"156.0"	"293.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3D3"	"28S ribosomal protein S16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1"	"9"	"1"	"1"	"1"	"137"	"15.3"	"9.50"	""	"2.59"	""	"1"	"protein metabolism;other metabolic processes"	"other membranes;cytosol;mitochondrion;translational apparatus"	"other molecular function"	"Pf00886"	"51021"	"ENSG00000182180"	"MRPS16"	"B4E032; hsa:51021; Q96Q60; Q9Y3D3"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P53999"	"Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3"	"10"	"1"	"2"	"1"	"127"	"14.4"	"9.60"	"239.67"	"2.59"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02229"	"10923"	"ENSG00000113387"	"SUB1"	"hsa:10923; P53999; Q96L29"	""	""	"0"	"0"	"14.6"	"10.7"	"18.8"	"24.6"	"30.4"	"21.8"	"123.8"	"128.0"	"46.7"	"68.2"	"116.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H444"	"Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1"	"5"	"1"	"2"	"1"	"224"	"24.9"	"4.82"	"368.90"	"2.59"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf03357"	"128866"	"ENSG00000101421"	"CHMP4B"	"E1P5N4; hsa:128866; Q53ZD6; Q9H444"	""	"Sealing of the nuclear envelope (NE) by ESCRT-III; HCMV Late Events; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex"	"9"	"0"	"39.5"	"29.9"	"26.8"	"45.3"	"58.0"	"61.2"	"97.1"	"101.6"	"82.2"	"96.5"	"132.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13310"	"Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1"	"2"	"1"	"2"	"1"	"644"	"70.7"	"9.26"	"288.07"	"2.59"	"1"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf00658"	"8761"	"ENSG00000090621"	"PABPC4"	"B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3"	""	""	"0"	"0"	"37.2"	"32.9"	"42.7"	"58.5"	"74.0"	"60.7"	"118.8"	"121.6"	"70.9"	"107.2"	"118.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P41227"	"N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1"	"3"	"1"	"2"	"1"	"235"	"26.4"	"5.64"	"338.30"	"2.58"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00583"	"8260"	"ENSG00000102030"	"NAA10"	"A6NM98; hsa:8260; P41227"	""	""	"0"	"0"	"16.1"	"17.8"	"19.6"	"26.7"	"35.6"	"32.7"	"89.1"	"92.3"	"66.9"	"84.6"	"148.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00401"	"Neural Wiskott-Aldrich syndrome protein OS=Homo sapiens OX=9606 GN=WASL PE=1 SV=2"	"2"	"1"	"2"	"1"	"505"	"54.8"	"7.93"	"312.48"	"2.58"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"enzyme regulator activity;cytoskeletal activity"	"Pf00568, Pf00786, Pf02205"	"8976"	"ENSG00000106299"	"WASL"	"A1JUI9; hsa:8976; O00401; Q7Z746"	"Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway"	"Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling"	"17"	"0"	"20.0"	"19.4"	"20.0"	"26.8"	"33.1"	"27.0"	"88.9"	"90.5"	"68.9"	"89.1"	"146.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UHB9"	"Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2"	"1"	"1"	"2"	"1"	"627"	"70.7"	"8.56"	"274.73"	"2.58"	"1"	"1"	"transport;other biological processes"	"cytosol;ER/Golgi;translational apparatus;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf16969"	"6730"	"ENSG00000167881"	"SRP68"	"B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9"	""	"SRP-dependent cotranslational protein targeting to membrane"	"1"	"0"	"11.1"	"6.5"	"7.3"	"12.6"	"16.5"	"13.2"	"49.3"	"39.2"	"23.2"	"27.3"	"34.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13643"	"Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4"	"4"	"1"	"2"	"1"	"280"	"31.2"	"6.20"	"279.57"	"2.58"	"1"	"1"	"cell organization and biogenesis;other biological processes"	"cytoskeleton;nucleus"	"cytoskeletal activity;other molecular function"	"Pf00412"	"2275"	"ENSG00000183386"	"FHL3"	"D3DPT6; hsa:2275; Q13643; Q6I9T0; Q9BVA2"	""	""	"0"	"0"	"27.6"	"22.2"	"35.3"	"37.2"	"39.1"	"41.3"	"61.1"	"59.6"	"48.9"	"73.6"	"98.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4F1"	"FERM, ARHGEF and pleckstrin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FARP1 PE=1 SV=1"	"1"	"1"	"2"	"1"	"1045"	"118.6"	"8.15"	"351.87"	"2.58"	"1"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00169, Pf00373, Pf00621, Pf08736, Pf09379, Pf09380"	"10160"	"ENSG00000152767"	"FARP1"	"hsa:10160; Q5JVI9; Q6IQ29; Q9Y4F1"	""	"RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOF GTPase cycle"	"4"	"0"	"10.0"	"9.9"	"6.9"	"10.9"	"20.0"	"15.1"	"43.5"	"30.6"	"26.9"	"28.5"	"38.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P81605"	"Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2"	"22"	"3"	"5"	"3"	"110"	"11.3"	"6.54"	"1231.00"	"2.57"	"3"	"1"	"protein metabolism;stress response;transport;other biological processes"	"non-structural extracellular;other membranes"	"transporter activity;other molecular function"	"Pf15291"	"117159"	"ENSG00000161634"	"DCD"	"A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2"	""	"Antimicrobial peptides"	"1"	"0"	"522.0"	"156.7"	"461.9"	"244.2"	"362.1"	"501.8"	"1033.6"	"1033.8"	"687.5"	"813.3"	"1064.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BPW8"	"Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1"	"7"	"2"	"3"	"2"	"284"	"33.3"	"9.31"	"630.38"	"2.57"	"2"	"1"	"other biological processes"	"plasma membrane;other membranes;mitochondrion"	"other molecular function"	"Pf07978"	"8508"	"ENSG00000184117"	"NIPSNAP1"	"B2RAY3; hsa:8508; O43800; Q9BPW8"	""	""	"0"	"0"	"34.7"	"23.1"	"35.2"	"51.4"	"58.2"	"40.9"	"198.0"	"194.2"	"114.0"	"128.3"	"123.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14232"	"Translation initiation factor eIF-2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"305"	"33.7"	"7.33"	"309.64"	"2.56"	"1"	"1"	"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01008"	"1967"	"ENSG00000111361"	"EIF2B1"	"A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4"	"Translation factors"	"Recycling of eIF2:GDP"	"2"	"0"	"29.3"	"15.9"	"31.4"	"50.0"	"56.1"	"49.4"	"105.7"	"81.6"	"60.3"	"86.6"	"108.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P265"	"Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3"	"1"	"1"	"2"	"1"	"1576"	"171.4"	"8.09"	"310.13"	"2.56"	"1"	"1"	"cell organization and biogenesis;developmental processes;other biological processes"	"nucleus;other cell component"	"cytoskeletal activity"	"Pf00501, Pf06464"	"57609"	"ENSG00000066084"	"DIP2B"	"hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265"	""	""	"0"	"0"	"0.0"	"0.0"	"2.5"	"2.3"	"3.3"	"4.1"	"27.5"	"55.2"	"40.3"	"50.2"	"96.2"	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P10619"	"Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2"	"2"	"1"	"2"	"1"	"480"	"54.4"	"6.61"	"326.60"	"2.56"	"1"	"1"	"protein metabolism;transport;other biological processes"	"non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00450"	"5476"	"ENSG00000064601"	"CTSA"	"B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68"	"Ciliary landscape"	"MHC class II antigen presentation; Neutrophil degranulation; Glycosphingolipid metabolism; Sialic acid metabolism; Defective NEU1 causes sialidosis"	"6"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94761"	"ATP-dependent DNA helicase Q4 OS=Homo sapiens OX=9606 GN=RECQL4 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1208"	"133.0"	"8.09"	"386.23"	"2.56"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf11719"	"9401"	"ENSG00000160957"	"RECQL4"	"A0A087WZ30; hsa:9401; O94761; Q3Y424; Q96DW2; Q96F55"	"Primary ovarian insufficiency"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H3G5"	"Probable serine carboxypeptidase CPVL OS=Homo sapiens OX=9606 GN=CPVL PE=1 SV=2"	"2"	"1"	"1"	"1"	"476"	"54.1"	"5.62"	""	"2.56"	""	"1"	"protein metabolism"	""	"other molecular function"	"Pf00450"	"54504"	"ENSG00000106066"	"CPVL"	"A4D1A4; hsa:54504; Q6UX20; Q8NBL7; Q96AR7; Q9H3G5; Q9HB41"	""	""	"0"	"0"	"19.4"	"15.3"	"21.6"	"27.7"	"32.2"	"30.9"	"81.8"	"72.9"	"43.1"	"63.3"	"87.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14241"	"Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=2"	"3"	"2"	"4"	"2"	"798"	"89.9"	"9.57"	"1362.07"	"2.55"	"2"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf06881, Pf08711"	"6924"	"ENSG00000011007"	"ELOA"	"B2R7Q8; hsa:6924; Q14241; Q8IXH1"	"VEGFA-VEGFR2 signaling; 10q11.21q11.23 copy number variation syndrome"	"TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events"	"13"	"0"	"34.5"	"26.0"	"41.4"	"57.2"	"76.8"	"78.2"	"240.1"	"421.9"	"569.4"	"1217.0"	"2304.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BWU0"	"Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=1"	"4"	"3"	"4"	"3"	"796"	"88.8"	"5.19"	"1209.90"	"2.55"	"3"	"1"	""	"plasma membrane;other membranes;nucleus;other cell component"	"nucleic acid binding activity"	"Pf00498"	"22950"	"ENSG00000163798"	"SLC4A1AP"	"A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2"	""	""	"0"	"0"	"70.0"	"60.0"	"79.4"	"109.9"	"113.7"	"105.7"	"273.9"	"257.7"	"171.3"	"181.2"	"245.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13155"	"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2"	"4"	"1"	"2"	"1"	"320"	"35.3"	"8.22"	"299.95"	"2.55"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf14497, Pf16780, Pf18569"	"7965"	"ENSG00000106305"	"AIMP2"	"F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2"	"Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation"	"Selenoamino acid metabolism; Cytosolic tRNA aminoacylation"	"5"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N3R9"	"MAGUK p55 subfamily member 5 OS=Homo sapiens OX=9606 GN=MPP5 PE=1 SV=3"	"3"	"2"	"4"	"2"	"675"	"77.2"	"6.14"	"836.32"	"2.55"	"2"	"1"	"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes"	"plasma membrane;other membranes;ER/Golgi;other cell component"	"other molecular function"	"Pf00595, Pf00625, Pf02828, Pf07653, Pf09060"	"64398"	"ENSG00000072415"	"PALS1"	"A1L380; hsa:64398; Q7Z631; Q86T98; Q8N3R9; Q8N7I5; Q9H9Q0"	"Epithelial to mesenchymal transition in colorectal cancer; Complement system in neuronal development and plasticity"	"Tight junction interactions; SARS-CoV-2 targets PDZ proteins in cell-cell junction; SARS-CoV-1 targets PDZ proteins in cell-cell junction"	"5"	"0"	"21.3"	"14.3"	"27.7"	"41.2"	"40.4"	"42.5"	"75.0"	"78.1"	"42.0"	"53.7"	"53.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00193"	"Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1"	"4"	"1"	"2"	"1"	"183"	"20.3"	"4.72"	"290.81"	"2.55"	"1"	"1"	""	""	""	"Pf15477"	"10944"	"ENSG00000110696"	"SMAP"	"B2RD28; hsa:10944; O00193"	""	""	"0"	"0"	"50.1"	"32.4"	"49.2"	"72.4"	"113.4"	"94.7"	"231.0"	"222.1"	"125.5"	"156.2"	"187.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15118"	"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"436"	"49.2"	"8.81"	"277.04"	"2.55"	"1"	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"mitochondrion"	"kinase activity;other molecular function"	"Pf02518, Pf10436"	"5163"	"ENSG00000152256"	"PDK1"	"B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4"	"T cell receptor and co-stimulatory signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; EPO receptor signaling; DNA damage response (only ATM dependent)"	"Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid"	"19"	"0"	"9.1"	"7.5"	"13.0"	"17.3"	"17.3"	"14.9"	"60.7"	"57.0"	"35.6"	"42.1"	"65.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P21266"	"Glutathione S-transferase Mu 3 OS=Homo sapiens OX=9606 GN=GSTM3 PE=1 SV=3"	"8"	"1"	"2"	"1"	"225"	"26.5"	"5.54"	"279.88"	"2.54"	"1"	"1"	"other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf00043, Pf02798"	"2947"	"ENSG00000134202"	"GSTM3"	"hsa:2947; O60550; P21266; Q96HA3"	"Nuclear receptors meta-pathway; NRF2 pathway; Exercise-induced circadian regulation; Metapathway biotransformation Phase I and II"	"Glutathione conjugation"	"5"	"0"	"9.0"	"2.7"	"7.8"	"10.2"	"9.7"	"8.0"	"24.0"	"16.3"	"10.8"	"17.0"	"36.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13576"	"Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4"	"1"	"1"	"2"	"1"	"1575"	"180.5"	"5.64"	"299.88"	"2.54"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"enzyme regulator activity;cytoskeletal activity;other molecular function"	"Pf00307, Pf00612, Pf00616, Pf03836"	"10788"	"ENSG00000145703"	"IQGAP2"	"A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576"	"Ciliary landscape; G13 signaling pathway"	"Neutrophil degranulation; RHOG GTPase cycle; RHO GTPases activate IQGAPs; CDC42 GTPase cycle; RAC1 GTPase cycle"	"7"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82930"	"28S ribosomal protein S34, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2"	"4"	"1"	"2"	"1"	"218"	"25.6"	"9.98"	"321.33"	"2.54"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf16053"	"65993"	"ENSG00000074071"	"MRPS34"	"hsa:65993; P82930; Q9BVI7"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"71.6"	"49.3"	"67.7"	"99.2"	"114.3"	"107.2"	"212.7"	"177.1"	"119.5"	"145.5"	"194.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12872"	"Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3"	"1"	"1"	"2"	"1"	"951"	"104.8"	"8.05"	"254.48"	"2.54"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf01805, Pf09750"	"6433"	"ENSG00000061936"	"SFSWAP"	"B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7"	"mRNA processing"	""	"1"	"0"	"8.1"	"6.0"	"3.0"	"6.8"	"9.7"	"5.4"	"20.6"	"26.7"	"11.9"	"17.1"	"20.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UL18"	"Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3"	"1"	"1"	"1"	"1"	"857"	"97.2"	"9.16"	""	"2.53"	""	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488"	"26523"	"ENSG00000092847"	"AGO1"	"hsa:26523; Q5TA57; Q6P4S0; Q9UL18"	"Modulators of TCR signaling and T cell activation"	"Oxidative Stress Induced Senescence; Ca2+ pathway; MAPK6/MAPK4 signaling; Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation"	"22"	"0"	"3.0"	"2.9"	"3.9"	"8.3"	"9.6"	"5.7"	"23.9"	"26.6"	"26.8"	"27.2"	"28.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H0W8"	"Protein SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1"	"3"	"1"	"2"	"1"	"520"	"57.6"	"7.01"	"276.99"	"2.53"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;developmental processes"	"cytosol"	"other molecular function"	"Pf10220"	"56006"	"ENSG00000105771"	"SMG9"	"hsa:56006; O60429; Q9H0W8; Q9H9A9"	""	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13984"	"General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2"	"4"	"1"	"2"	"1"	"249"	"28.4"	"9.23"	"290.28"	"2.53"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytoskeleton;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf02270, Pf17683"	"2963"	"ENSG00000188342"	"GTF2F2"	"A6NNS5; hsa:2963; P13984; Q5W0H3"	"Eukaryotic transcription initiation"	"mRNA Splicing - Major Pathway; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM"	"33"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UJ83"	"2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2"	"1"	"1"	"2"	"1"	"578"	"63.7"	"7.36"	"297.30"	"2.52"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;transport"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00205, Pf02775, Pf02776"	"26061"	"ENSG00000131373"	"HACL1"	"B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83"	""	"Peroxisomal protein import; Alpha-oxidation of phytanate"	"2"	"0"	"14.2"	"12.0"	"18.8"	"22.4"	"28.1"	"19.5"	"67.1"	"82.8"	"52.8"	"73.0"	"162.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14137"	"Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2"	"1"	"1"	"2"	"1"	"746"	"83.6"	"6.19"	"278.28"	"2.52"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00400, Pf08145"	"23246"	"ENSG00000261236; ENSG00000285301"	"BOP1"	"hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NAN2"	"Mitoguardin 1 OS=Homo sapiens OX=9606 GN=MIGA1 PE=1 SV=1"	"3"	"1"	"1"	"1"	"632"	"71.0"	"5.63"	""	"2.51"	""	"1"	"cell organization and biogenesis"	"plasma membrane;other membranes;mitochondrion"	"other molecular function"	"Pf10265"	"374986"	"ENSG00000180488"	"MIGA1"	"hsa:374986; Q6MZG0; Q8NAN2"	""	"Synthesis of PA"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HD33"	"39S ribosomal protein L47, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2"	"4"	"1"	"2"	"1"	"250"	"29.4"	"10.37"	"289.07"	"2.51"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf06984"	"57129"	"ENSG00000136522"	"MRPL47"	"hsa:57129; Q6XRG1; Q8N5D1; Q9HD33"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"15.2"	"12.4"	"16.4"	"23.6"	"28.1"	"22.5"	"47.4"	"38.3"	"24.8"	"37.3"	"43.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P07954"	"Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3"	"2"	"1"	"2"	"1"	"510"	"54.6"	"8.76"	"249.98"	"2.51"	"1"	"1"	"DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00206, Pf10415"	"2271"	"ENSG00000091483"	"FH"	"B1ANK7; hsa:2271; P07954"	"TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)"	"Citric acid cycle (TCA cycle)"	"8"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12789"	"General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4"	"0"	"1"	"2"	"1"	"2109"	"238.7"	"7.30"	"275.57"	"2.51"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04182"	"2975"	"ENSG00000077235"	"GTF3C1"	"B2RP21; hsa:2975; Q12789; Q12838; Q6DKN9; Q9Y4W9"	""	"RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter"	"3"	"0"	"8.8"	"6.8"	"9.6"	"15.0"	"19.9"	"13.2"	"37.5"	"40.7"	"21.6"	"24.3"	"33.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51452"	"Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1"	"6"	"1"	"2"	"1"	"185"	"20.5"	"7.80"	"343.15"	"2.50"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00782"	"1845"	"ENSG00000108861"	"DUSP3"	"D3DX45; hsa:1845; P51452; Q5U0J1; Q8IYJ9"	"MAPK signaling pathway; Fragile X syndrome"	"ERKs are inactivated"	"3"	"0"	"8.5"	"5.7"	"11.7"	"16.7"	"19.0"	"12.6"	"40.8"	"40.1"	"23.7"	"42.3"	"39.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00418"	"Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2"	"1"	"1"	"2"	"1"	"725"	"82.1"	"5.33"	"299.10"	"2.50"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;other cell component"	"nucleic acid binding activity;kinase activity;other molecular function"	"Pf02816, Pf08238"	"29904"	"ENSG00000103319"	"EEF2K"	"hsa:29904; O00418; Q8N588"	"Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling"	"mTORC1-mediated signalling"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99848"	"Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2"	"3"	"1"	"2"	"1"	"306"	"34.8"	"10.10"	"349.10"	"2.49"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf05890"	"10969"	"ENSG00000117395"	"EBNA1BP2"	"hsa:10969; Q96A66; Q99848"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"48.3"	"33.2"	"47.1"	"58.4"	"75.5"	"65.5"	"193.1"	"194.4"	"135.7"	"159.3"	"172.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WWM7"	"Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2"	"1"	"1"	"2"	"1"	"1075"	"113.3"	"8.59"	"263.37"	"2.49"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf06741, Pf07145, Pf14438"	"11273"	"ENSG00000168488"	"ATXN2L"	"A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703"	"16p11.2 distal deletion syndrome"	""	"1"	"0"	"24.1"	"19.9"	"25.1"	"27.5"	"33.2"	"30.8"	"80.4"	"63.1"	"52.4"	"62.3"	"53.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O96008"	"Mitochondrial import receptor subunit TOM40 homolog OS=Homo sapiens OX=9606 GN=TOMM40 PE=1 SV=1"	"3"	"1"	"2"	"1"	"361"	"37.9"	"7.25"	"285.66"	"2.49"	"1"	"1"	"cell organization and biogenesis;transport"	"other membranes;cytosol;mitochondrion;other cell component"	"transporter activity"	"Pf01459"	"10452"	"ENSG00000130204"	"TOMM40"	"A0A024R0P9; hsa:10452; O96008; Q86VW4; Q8WY09; Q8WY10; Q8WY11; Q9BR95"	"IL-18 signaling pathway"	"Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P17812"	"CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"591"	"66.6"	"6.46"	"373.54"	"2.49"	"1"	"1"	"cell cycle OR cell proliferation;other metabolic processes;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00117, Pf06418"	"1503"	"ENSG00000171793"	"CTPS1"	"B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6"	"Pyrimidine metabolism"	"Interconversion of nucleotide di- and triphosphates"	"2"	"0"	"21.2"	"10.7"	"23.1"	"35.3"	"42.3"	"39.0"	"63.5"	"63.9"	"45.0"	"52.6"	"63.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NYJ1"	"Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2"	"20"	"2"	"2"	"2"	"87"	"10.1"	"6.04"	"719.40"	"2.48"	"1"	"1"	"cell organization and biogenesis"	"mitochondrion"	""	""	"51287"	"ENSG00000181924"	"COA4"	"B2RAA0; hsa:51287; Q69YU4; Q9NYJ1"	""	"Mitochondrial protein import"	"1"	"0"	"27.4"	"10.9"	"25.7"	"40.3"	"51.1"	"47.5"	"81.3"	"72.7"	"37.0"	"50.6"	"74.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P1F3"	"Costars family protein ABRACL OS=Homo sapiens OX=9606 GN=ABRACL PE=1 SV=1"	"16"	"1"	"2"	"1"	"81"	"9.1"	"6.29"	"307.95"	"2.48"	"1"	"1"	"other biological processes"	""	""	"Pf14705"	"58527"	"ENSG00000146386"	"ABRACL"	"hsa:58527; Q5SZC8; Q9P0A1; Q9P1F3"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NY12"	"H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1"	"4"	"1"	"2"	"1"	"217"	"22.3"	"10.92"	"300.64"	"2.48"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf04410"	"54433"	"ENSG00000109534"	"GAR1"	"hsa:54433; Q5MJQ2; Q9NY12"	""	"rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase"	"2"	"0"	"35.5"	"14.0"	"26.1"	"37.2"	"53.6"	"52.8"	"112.0"	"106.6"	"53.5"	"84.3"	"137.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IWZ8"	"SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2"	"2"	"1"	"1"	"1"	"645"	"72.4"	"7.61"	""	"2.47"	""	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf01585, Pf01805"	"57794"	"ENSG00000105705"	"SUGP1"	"hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3"	"mRNA processing"	"mRNA Splicing - Major Pathway"	"2"	"0"	"19.5"	"10.5"	"23.9"	"25.7"	"30.2"	"30.4"	"69.2"	"60.7"	"34.1"	"52.8"	"61.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00268"	"Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1085"	"110.0"	"9.94"	""	"2.47"	""	"1"	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function"	"Pf05236, Pf07531"	"6874"	"ENSG00000130699"	"TAF4"	"A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42"	""	"RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation"	"9"	"0"	"9.3"	"7.7"	"6.4"	"5.3"	"14.3"	"12.0"	"21.9"	"25.5"	"17.4"	"21.9"	"19.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BVS5"	"tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2"	"3"	"1"	"2"	"1"	"477"	"52.9"	"6.62"	"277.88"	"2.47"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"mitochondrion;other cell component"	"other molecular function"	"Pf08704"	"55006"	"ENSG00000171103"	"TRMT61B"	"hsa:55006; Q9BVS5; Q9H0Q9; Q9NWS7"	""	"tRNA modification in the mitochondrion"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q2VIQ3"	"Chromosome-associated kinesin KIF4B OS=Homo sapiens OX=9606 GN=KIF4B PE=2 SV=2"	"1"	"1"	"2"	"1"	"1234"	"139.9"	"6.18"	"240.28"	"2.47"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00225"	"285643"	"ENSG00000226650"	"KIF4B"	"hsa:285643; Q2VIQ3"	""	"COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Recycling pathway of L1; Kinesins"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12899"	"Tripartite motif-containing protein 26 OS=Homo sapiens OX=9606 GN=TRIM26 PE=1 SV=1"	"2"	"1"	"2"	"1"	"539"	"62.1"	"5.03"	"273.44"	"2.47"	"1"	"1"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00622, Pf00643, Pf13765, Pf15227"	"7726"	"ENSG00000137313; ENSG00000226060; ENSG00000228881; ENSG00000230230; ENSG00000231002; ENSG00000231641; ENSG00000234046; ENSG00000234127"	"TRIM26"	"A6NG96; hsa:7726; Q12899; Q5SRL2"	""	"Interferon gamma signaling"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49674"	"Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1"	"6"	"2"	"3"	"2"	"416"	"47.3"	"9.66"	"700.11"	"2.47"	"2"	"1"	"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"102800317; 1454"	"ENSG00000213923"	"CSNK1E"	"hsa:102800317; hsa:1454; P49674"	"Alzheimer's disease and miRNA effects; Melatonin metabolism and effects; Wnt signaling pathway; Wnt signaling pathway and pluripotency; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease"	"Major pathway of rRNA processing in the nucleolus and cytosol; WNT mediated activation of DVL; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock"	"20"	"0"	"13.1"	"6.3"	"8.7"	"13.3"	"15.0"	"12.1"	"41.3"	"59.1"	"27.7"	"37.3"	"47.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62328"	"Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2"	"16"	"1"	"2"	"1"	"44"	"5.1"	"5.06"	"310.59"	"2.47"	"1"	"1"	"cell organization and biogenesis;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf01290"	"7114"	"ENSG00000205542"	"TMSB4X"	"hsa:7114; P01253; P01254; P62328; Q546P5; Q63576; Q9UE55"	"Genes targeted by miRNAs in adipocytes; VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Regulation of actin cytoskeleton"	"Platelet degranulation"	"5"	"0"	"98.7"	"70.0"	"107.9"	"128.6"	"155.2"	"187.3"	"287.0"	"225.7"	"140.0"	"254.3"	"495.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NVR2"	"Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2"	"2"	"1"	"1"	"1"	"710"	"82.2"	"7.44"	""	"2.46"	""	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	""	""	"55174"	"ENSG00000104613"	"INTS10"	"hsa:55174; Q6IA93; Q7L538; Q7L8C8; Q9H3W8; Q9NVR2"	"1p36 copy number variation syndrome"	"RNA polymerase II transcribes snRNA genes"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BXF6"	"Rab11 family-interacting protein 5 OS=Homo sapiens OX=9606 GN=RAB11FIP5 PE=1 SV=1"	"2"	"1"	"2"	"1"	"653"	"70.4"	"9.23"	"234.30"	"2.46"	"1"	"1"	"cell-cell signaling;transport;other biological processes"	"other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00168, Pf09457"	"26056"	"ENSG00000135631"	"RAB11FIP5"	"hsa:26056; O94939; Q9BXF6; Q9P0M1"	""	""	"0"	"0"	"10.8"	"10.9"	"7.6"	"8.3"	"21.5"	"18.6"	"47.8"	"48.0"	"40.5"	"45.0"	"40.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BT88"	"Synaptotagmin-11 OS=Homo sapiens OX=9606 GN=SYT11 PE=1 SV=2"	"4"	"1"	"1"	"1"	"431"	"48.3"	"9.04"	""	"2.46"	""	"1"	"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes"	"plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00168"	"23208"	"ENSG00000132718"	"SYT11"	"hsa:23208; Q14998; Q5W0D4; Q68CT5; Q8IXU3; Q96SU2; Q9BT88"	"Parkinson's disease pathway"	"Cargo recognition for clathrin-mediated endocytosis"	"3"	"0"	"79.9"	"20.6"	"56.0"	"93.9"	"139.1"	"96.4"	"491.8"	"370.7"	"63.1"	"149.1"	"299.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UMS0"	"NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Homo sapiens OX=9606 GN=NFU1 PE=1 SV=2"	"5"	"1"	"1"	"1"	"254"	"28.4"	"5.07"	""	"2.46"	""	"1"	"cell organization and biogenesis;other metabolic processes"	"cytosol;mitochondrion;nucleus"	"other molecular function"	"Pf01106, Pf08712"	"27247"	"ENSG00000169599"	"NFU1"	"B4DUL9; hsa:27247; Q53QE5; Q6VNZ8; Q7Z5B1; Q7Z5B2; Q9UMS0; Q9Y322"	"Iron-sulfur cluster biogenesis"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96A65"	"Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1"	"1"	"1"	"1"	"1"	"974"	"110.4"	"6.49"	""	"2.46"	""	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf04048"	"60412"	"ENSG00000131558"	"EXOC4"	"E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102"	"Ciliary landscape"	"Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O14773"	"Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"563"	"61.2"	"6.48"	"302.25"	"2.46"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"other membranes;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00082, Pf09286"	"1200"	"ENSG00000166340"	"TPP1"	"hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37"	"VEGFA-VEGFR2 signaling"	"XBP1(S) activates chaperone genes"	"2"	"0"	"16.6"	"11.2"	"18.3"	"35.0"	"36.1"	"26.9"	"62.4"	"72.9"	"36.8"	"58.9"	"65.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96DR8"	"Mucin-like protein 1 OS=Homo sapiens OX=9606 GN=MUCL1 PE=1 SV=1"	"8"	"1"	"1"	"1"	"90"	"9.0"	"4.64"	""	"2.45"	""	"1"	""	"non-structural extracellular;plasma membrane;other membranes;ER/Golgi"	""	""	"118430"	"ENSG00000172551"	"MUCL1"	"hsa:118430; Q0VG95; Q32ZB5; Q96DR8"	""	"Dectin-2 family; Termination of O-glycan biosynthesis; Defective GALNT3 causes HFTC; Defective C1GALT1C1 causes TNPS; Defective GALNT12 causes CRCS1"	"6"	"0"	"51.4"	"34.0"	"40.0"	"38.9"	"61.1"	"66.2"	"295.4"	"340.5"	"223.2"	"272.1"	"253.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HAV7"	"GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2"	"5"	"1"	"2"	"1"	"217"	"24.3"	"8.12"	"346.23"	"2.45"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport"	"other membranes;mitochondrion;nucleus"	"other molecular function"	"Pf01025"	"80273"	"ENSG00000109519"	"GRPEL1"	"B2R783; hsa:80273; Q549M6; Q9HAV7"	""	"Mitochondrial protein import"	"1"	"0"	"8.0"	"0.0"	"7.4"	"12.3"	"15.4"	"13.5"	"21.6"	"27.1"	"13.7"	"15.6"	"36.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BQG0"	"Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2"	"1"	"1"	"2"	"1"	"1328"	"148.8"	"9.28"	"262.18"	"2.45"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04931"	"10514"	"ENSG00000132382"	"MYBBP1A"	"hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99"	"Energy metabolism; 10q11.21q11.23 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q29RF7"	"Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1"	"1"	"1"	"2"	"1"	"1337"	"150.7"	"7.91"	"312.53"	"2.45"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	""	"Pf20168"	"23244"	"ENSG00000121892"	"PDS5A"	"hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4"	"Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin"	"6"	"0"	"41.2"	"29.6"	"45.0"	"46.4"	"58.9"	"62.9"	"147.4"	"153.0"	"100.8"	"127.3"	"204.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q06323"	"Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1"	"5"	"1"	"1"	"1"	"249"	"28.7"	"6.02"	""	"2.45"	""	"1"	"other biological processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity"	"Pf02251, Pf02252"	"5720"	"ENSG00000092010; ENSG00000284916"	"PSME1"	"A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4"	"Proteasome degradation"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"60"	"0"	"10.3"	"7.6"	"12.7"	"15.3"	"17.8"	"16.2"	"43.5"	"42.9"	"27.8"	"44.3"	"71.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82914"	"28S ribosomal protein S15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1"	"3"	"1"	"2"	"1"	"257"	"29.8"	"10.48"	"276.76"	"2.45"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	"other molecular function"	"Pf00312"	"64960"	"ENSG00000116898"	"MRPS15"	"B2RD82; hsa:64960; P82914; Q9H2K1"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"48.1"	"41.7"	"41.2"	"67.0"	"93.7"	"83.8"	"147.2"	"126.4"	"76.1"	"108.6"	"136.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25325"	"3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3"	"6"	"2"	"3"	"1"	"297"	"33.2"	"6.60"	"561.81"	"2.45"	"2"	"1"	"other metabolic processes;developmental processes;other biological processes"	"cytosol;mitochondrion;other cell component"	"other molecular function"	"Pf00581"	"4357"	"ENSG00000128309"	"MPST"	"A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9"	"Trans-sulfuration pathway; Amino acid metabolism"	"Degradation of cysteine and homocysteine"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5SRE5"	"Nucleoporin NUP188 homolog OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1"	"1"	"1"	"2"	"1"	"1749"	"195.9"	"6.73"	"328.38"	"2.45"	"1"	"1"	"transport"	"cytosol;nucleus"	"other molecular function"	"Pf10487"	"23511"	"ENSG00000095319"	"NUP188"	"hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; Vpr-mediated nuclear import of PICs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of chromatin organization proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation"	"29"	"0"	"17.1"	"12.0"	"13.9"	"19.5"	"21.4"	"18.6"	"37.1"	"43.3"	"24.0"	"39.9"	"39.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49903"	"Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2"	"5"	"1"	"1"	"1"	"392"	"42.9"	"5.97"	""	"2.45"	""	"1"	"protein metabolism;other metabolic processes"	"plasma membrane;other membranes;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00586, Pf02769"	"22929"	"ENSG00000086475"	"SEPHS1"	"B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4"	""	""	"0"	"0"	"11.0"	"11.8"	"9.0"	"13.6"	"19.6"	"17.5"	"40.8"	"42.8"	"19.7"	"39.2"	"47.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P0M9"	"39S ribosomal protein L27, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1"	"4"	"1"	"1"	"1"	"148"	"16.1"	"10.42"	""	"2.44"	""	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf01016"	"51264"	"ENSG00000108826"	"MRPL27"	"B2RE14; hsa:51264; Q9P0M9"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"15.2"	"8.9"	"14.1"	"15.5"	"18.3"	"19.9"	"45.9"	"42.8"	"31.7"	"43.3"	"49.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16637"	"Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"294"	"31.8"	"6.55"	"272.90"	"2.44"	"1"	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf06003"	"6606; 6607"	"ENSG00000172062; ENSG00000205571; ENSG00000273772; ENSG00000275349; ENSG00000277773"	"SMN1; SMN2"	"A8K0V4; hsa:6606; hsa:6607; Q13119; Q16637; Q549U5; Q96J51"	""	"snRNP Assembly; SARS-CoV-2 modulates host translation machinery"	"2"	"0"	"13.5"	"3.5"	"9.6"	"12.1"	"18.7"	"14.5"	"47.0"	"33.2"	"11.1"	"30.2"	"32.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H1Z9"	"Tetraspanin-10 OS=Homo sapiens OX=9606 GN=TSPAN10 PE=2 SV=1"	"2"	"1"	"1"	"1"	"355"	"36.5"	"5.86"	""	"2.44"	""	"1"	"other biological processes"	"other membranes"	"other molecular function"	"Pf00335"	"83882"	""	"TSPAN10"	"hsa:83882; Q8N548; Q9H1Z9"	""	""	"0"	"0"	"64.2"	"55.7"	"64.6"	"79.2"	"129.6"	"128.1"	"225.0"	"240.7"	"150.1"	"199.4"	"299.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95336"	"6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2"	"5"	"1"	"1"	"1"	"258"	"27.5"	"6.05"	""	"2.44"	""	"1"	"other metabolic processes"	"cytosol"	"other molecular function"	"Pf01182"	"25796"	"ENSG00000130313"	"PGLS"	"hsa:25796; O95336"	"Pentose phosphate metabolism"	"Pentose phosphate pathway"	"2"	"0"	"31.5"	"21.4"	"27.0"	"43.4"	"45.8"	"42.1"	"77.0"	"77.9"	"57.5"	"80.1"	"115.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31153"	"S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1"	"2"	"1"	"2"	"1"	"395"	"43.6"	"6.48"	"277.71"	"2.44"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00438, Pf02772, Pf02773"	"4144"	"ENSG00000168906"	"MAT2A"	"A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5"	"Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Methylation pathways"	"Methylation"	"4"	"0"	"53.8"	"48.3"	"55.8"	"68.2"	"87.1"	"84.5"	"126.3"	"114.0"	"93.4"	"122.4"	"171.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z6Z7"	"E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3"	"1"	"1"	"1"	"1"	"4374"	"481.6"	"5.22"	""	"2.44"	""	"1"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377"	"10075"	"ENSG00000086758"	"HUWE1"	"hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9"	""	"Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"High"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"P31939"	"Bifunctional purine biosynthesis protein PURH OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3"	"2"	"1"	"2"	"1"	"592"	"64.6"	"6.71"	"269.23"	"2.43"	"1"	"1"	"other metabolic processes;developmental processes;other biological processes"	"plasma membrane;other membranes;cytosol"	"other molecular function"	"Pf01808, Pf02142"	"471"	"ENSG00000138363"	"ATIC"	"A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28"	"One-carbon metabolism"	"Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis"	"3"	"0"	"4.0"	"3.6"	"3.7"	"6.4"	"10.3"	"5.0"	"16.0"	"18.0"	"15.2"	"19.9"	"34.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51160"	"Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' OS=Homo sapiens OX=9606 GN=PDE6C PE=1 SV=2"	"1"	"1"	"2"	"1"	"858"	"99.1"	"5.72"	"318.20"	"2.43"	"1"	"1"	"developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes"	"other molecular function"	"Pf00233, Pf01590"	"5146"	"ENSG00000095464"	"PDE6C"	"A6NCR6; hsa:5146; P51160; Q5VY29"	"Phosphodiesterases in neuronal function"	""	"1"	"0"	"16.7"	"12.3"	"22.8"	"29.1"	"41.0"	"32.8"	"92.2"	"74.9"	"56.8"	"84.7"	"141.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13200"	"26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3"	"1"	"1"	"2"	"1"	"908"	"100.1"	"5.20"	"332.78"	"2.42"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"enzyme regulator activity"	"Pf01851, Pf17781, Pf18051"	"5708"	"ENSG00000175166"	"PSMD2"	"B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12"	"Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"ER-Phagosome pathway; Neutrophil degranulation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"65"	"0"	"12.4"	"7.6"	"11.6"	"18.1"	"21.8"	"23.0"	"38.9"	"47.9"	"26.3"	"31.3"	"50.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P61204"	"ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2"	"6"	"1"	"1"	"1"	"181"	"20.6"	"7.43"	""	"2.42"	""	"1"	"transport"	"plasma membrane;other membranes;ER/Golgi;other cell component"	"other molecular function"	"Pf00025"	"377"	"ENSG00000134287"	"ARF3"	"A8K6G8; B7ZB63; hsa:377; P16587; P61204"	""	"COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P56381"	"ATP synthase subunit epsilon, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1E PE=1 SV=2"	"16"	"1"	"2"	"1"	"51"	"5.8"	"9.92"	"295.03"	"2.42"	"1"	"1"	"other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf04627"	"514"	"ENSG00000124172"	"ATP5F1E"	"B2RDD0; E1P5H6; hsa:514; P56381; Q53XU6"	"Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation"	"Cristae formation; Formation of ATP by chemiosmotic coupling"	"5"	"0"	"48.3"	"37.6"	"48.9"	"86.8"	"102.5"	"96.8"	"159.9"	"163.5"	"128.8"	"177.7"	"207.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30048"	"Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3"	"3"	"1"	"2"	"1"	"256"	"27.7"	"7.78"	"338.64"	"2.42"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00578, Pf10417"	"10935"	"ENSG00000165672"	"PRDX3"	"B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4"	"Selenium micronutrient network"	"Detoxification of Reactive Oxygen Species"	"2"	"0"	"90.1"	"38.3"	"59.6"	"104.8"	"120.0"	"141.5"	"226.0"	"196.4"	"101.6"	"157.5"	"278.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P32238"	"Cholecystokinin receptor type A OS=Homo sapiens OX=9606 GN=CCKAR PE=1 SV=1"	"3"	"1"	"1"	"1"	"428"	"47.8"	"9.20"	""	"2.42"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus"	"other molecular function"	"Pf00001, Pf09193"	"886"	"ENSG00000163394"	"CCKAR"	"B2R9Z5; hsa:886; P32238"	"Peptide GPCRs; GPCRs, class A rhodopsin-like"	"G alpha (q) signalling events; Peptide ligand-binding receptors"	"4"	"0"	"38.0"	"26.8"	"32.3"	"42.7"	"61.3"	"43.1"	"114.0"	"116.5"	"89.7"	"100.9"	"122.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3E1"	"Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1"	"4"	"1"	"2"	"1"	"203"	"22.6"	"7.99"	"305.55"	"2.42"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"cytosol;nucleus"	"signal transduction activity or receptor binding;cytoskeletal activity"	"Pf00855"	"50810"	"ENSG00000166503"	"HDGFL3"	"hsa:50810; Q9Y3E1"	""	""	"0"	"0"	"31.1"	"19.7"	"36.3"	"40.3"	"64.2"	"44.7"	"253.5"	"263.5"	"149.5"	"206.2"	"249.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5Z4"	"Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1"	"6"	"1"	"2"	"1"	"205"	"22.9"	"4.63"	"264.44"	"2.42"	"1"	"1"	"cell organization and biogenesis;transport;other biological processes"	"non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf04832"	"23593"	"ENSG00000051620"	"HEBP2"	"hsa:23593; Q96P57; Q9Y5Z4"	""	"Neutrophil degranulation"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A0AVT1"	"Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1"	"1"	"1"	"2"	"1"	"1052"	"117.9"	"6.14"	"253.99"	"2.42"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;other cell component"	"other molecular function"	"Pf00899, Pf09358, Pf10585, Pf16190, Pf16191"	"55236"	"ENSG00000033178"	"UBA6"	"A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9"	""	"Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P48201"	"ATP synthase F(0) complex subunit C3, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MC3 PE=1 SV=1"	"5"	"1"	"2"	"1"	"142"	"14.7"	"9.45"	"309.52"	"2.42"	"1"	"1"	"other metabolic processes;transport"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf00137"	"518"	"ENSG00000154518"	"ATP5MC3"	"B2R4Z0; D3DPF0; hsa:518; P48201; Q4ZFX7"	"Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation"	"Cristae formation; Formation of ATP by chemiosmotic coupling"	"5"	"0"	"112.2"	"61.7"	"95.7"	"115.6"	"138.6"	"106.0"	"678.4"	"1643.4"	"619.4"	"620.7"	"675.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23258"	"Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"451"	"51.1"	"6.14"	"299.69"	"2.41"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis"	"cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00091, Pf03953"	"7283"	"ENSG00000131462"	"TUBG1"	"hsa:7283; P23258; Q53X79; Q9BW59"	"Alstrom syndrome"	"Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2"	"8"	"0"	"14.9"	"15.3"	"21.2"	"22.3"	"28.4"	"30.2"	"81.4"	"77.3"	"66.1"	"107.6"	"210.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKJ3"	"G patch domain-containing protein 8 OS=Homo sapiens OX=9606 GN=GPATCH8 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1502"	"164.1"	"8.66"	""	"2.41"	""	"1"	""	"nucleus"	"other molecular function"	"Pf01585, Pf12171"	"23131"	"ENSG00000186566"	"GPATCH8"	"B9EGP9; hsa:23131; O60300; Q8TB99; Q9UKJ3"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P36776"	"Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2"	"1"	"1"	"2"	"1"	"959"	"106.4"	"6.39"	"246.83"	"2.41"	"1"	"1"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00004, Pf02190, Pf05362"	"9361"	"ENSG00000196365"	"LONP1"	"B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95"	""	""	"0"	"0"	"6.6"	"3.8"	"5.5"	"8.5"	"12.9"	"10.8"	"17.4"	"19.6"	"8.8"	"19.1"	"23.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6PRD1"	"Probable G-protein coupled receptor 179 OS=Homo sapiens OX=9606 GN=GPR179 PE=1 SV=2"	"1"	"1"	"1"	"1"	"2367"	"257.2"	"5.71"	""	"2.41"	""	"1"	"signal transduction;other biological processes"	"plasma membrane;other membranes"	"other molecular function"	"Pf00003"	"440435"	"ENSG00000276469"	"GPR179"	"hsa:440435; Q6PRD1"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NBL1"	"Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1"	"3"	"1"	"1"	"1"	"392"	"46.2"	"8.72"	""	"2.40"	""	"1"	"protein metabolism;other metabolic processes;developmental processes;other biological processes"	"ER/Golgi;other cell component"	"other molecular function"	"Pf05686"	"56983"	"ENSG00000163389"	"POGLUT1"	"B2RD13; hsa:56983; Q53GJ4; Q8N2T1; Q8NBL1"	""	"Pre-NOTCH Processing in the Endoplasmic Reticulum"	"1"	"0"	"5.9"	"5.0"	"6.4"	"12.2"	"11.0"	"12.4"	"22.4"	"24.2"	"16.4"	"20.8"	"37.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H081"	"Protein MIS12 homolog OS=Homo sapiens OX=9606 GN=MIS12 PE=1 SV=1"	"5"	"1"	"2"	"1"	"205"	"24.1"	"5.69"	"277.30"	"2.40"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf05859"	"79003"	"ENSG00000167842"	"MIS12"	"hsa:79003; Q96N24; Q9H081"	""	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"6"	"0"	"6.7"	"3.4"	"5.6"	"8.2"	"11.2"	"11.5"	"23.2"	"24.9"	"13.2"	"19.4"	"32.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BVG4"	"Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1"	"5"	"1"	"2"	"1"	"233"	"26.0"	"4.79"	"310.14"	"2.40"	"1"	"1"	""	""	""	"Pf04669"	"51260"	"ENSG00000102390"	"PBDC1"	"hsa:51260; Q9BVG4"	""	""	"0"	"0"	"0.0"	"3.1"	"3.7"	"7.7"	"8.3"	"5.4"	"19.9"	"19.9"	"16.6"	"13.6"	"21.5"	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75367"	"Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=4"	"5"	"1"	"2"	"1"	"372"	"39.6"	"9.79"	"271.36"	"2.40"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00125, Pf01661, Pf16211"	"100394084; 100998964; 101131222; 101381952; 101564704; 101706296; 102008188; 102123677; 103079324; 104855290; 105467125; 105506940; 105531308; 105816031; 105869993; 108529540; 462076; 481514; 711836"	"ENSAMEG00000017887; ENSBMSG00010001156; ENSCAFG00000001076; ENSCAFG00020007175; ENSCAFG00030007355; ENSCAFG00040009734; ENSCANG00000022762; ENSCJAG00000005818; ENSCLAG00000016530; ENSCWAG00000001657; ENSFCAG00000013924; ENSGGOG00000001707; ENSLCNG00005003680; ENSMICG00000005677; ENSMLEG00000037795; ENSMMNG00015002866; ENSMNEG00000031666; ENSMPUG00000010011; ENSPANG00000002758; ENSPCOG00000013464; ENSPCTG00005011747; ENSPLOG00000000479; ENSPPAG00000029258; ENSPPYG00000015799; ENSPSMG00000021213; ENSPSNG00000019193; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSSVLG00005008251; ENSTGEG00000021330; ENSVVUG00000017487"	"H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC105869993; LOC106989149; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112625777; LOC112815157; LOC112861289; LOC112917035; LOC113928700; LOC114891795; LOC115516119; LOC116529369; LOC116750637; MACROH2A1"	"A0A091CNU6; A0A096N0E8; A0A2J8LRK8; A0A2J8VQ67; A0A2K5HRC8; A0A2K5W7N1; A0A2K5ZHE4; A0A2K6BUT6; A0A2K6EU20; A0A2K6LBL0; A0A2K6RXM8; A0A2K6UYW1; A0A2R9A926; A0A2U3WAW1; A0A2Y9IU30; A0A2Y9PFA0; A0A2Y9SS16; A0A340XJ26; A0A341BZA5; A0A3Q7NDG6; A0A3Q7S763; A0A484GVZ9; A0A485NYK5; A0A5S6R987; A0A667GC30; A0A673T0D7; A0A6G1ASZ6; A0A6J2AVA7; A0A6J2DX40; A0A6J3FC37; A0A6J3R528; A0A6P3F5E4; A0A6P6HX24; A0A8B7G616; A0A8C0C880; A0A8C0K484; A0A8C0S4U0; A0A8C2W4Z6; A0A8C3VQP8; A0A8C6F240; A0A8C8WAC0; A0A8C9AAB1; A0A8C9CK62; A0A8D2BC14; A0A8D2FWT2; A0A8I5UBU0; A0A8J8XTA7; A0A8M1F844; A0A8M1MQV0; A0A8P0N4A7; aju:106989149; cang:105506940; D2GVK3; dle:111182462; elk:111141291; F7HN69; G3QH59; G5BQ26; G7MUD7; ggo:101131222; H2QRI8; I2CUE9; lve:103079324; M3WJR3; M3YF29; mcf:102123677; mleu:105531308; mmur:105869993; mni:105467125; mpuf:101692673; nsu:110591142; oro:101381952; panu:100998964; pcad:102987354; pcoq:105816031; ptr:462076; rbb:108529540; sbq:101050376; umr:103663804; vvp:112917035; zca:113928700"	""	""	"0"	"0"	"4.5"	"3.1"	"7.3"	"6.6"	"7.7"	"11.8"	"20.1"	"21.0"	"14.8"	"16.6"	"23.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P00390"	"Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2"	"2"	"1"	"2"	"1"	"522"	"56.2"	"8.50"	"282.09"	"2.39"	"1"	"1"	"other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion"	"other molecular function"	"Pf00070, Pf02852"	"2936"	"ENSG00000104687"	"GSR"	"C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63"	"Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II"	""	"10"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08758"	"Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2"	"5"	"2"	"3"	"2"	"320"	"35.9"	"5.05"	"548.61"	"2.39"	"2"	"1"	"stress response;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00191"	"308"	"ENSG00000164111"	"ANXA5"	"D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9"	"Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation"	"Platelet degranulation"	"4"	"0"	"72.9"	"76.1"	"87.9"	"94.0"	"118.6"	"134.6"	"215.5"	"180.2"	"125.9"	"177.9"	"297.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96GQ7"	"Probable ATP-dependent RNA helicase DDX27 OS=Homo sapiens OX=9606 GN=DDX27 PE=1 SV=2"	"4"	"3"	"5"	"3"	"796"	"89.8"	"9.28"	"973.60"	"2.39"	"3"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"other molecular function"	"Pf00270, Pf00271"	"55661"	""	"DDX27"	"A0AVB6; B7ZLY1; hsa:55661; Q5VXM7; Q8WYG4; Q969N7; Q96F57; Q96GQ7; Q96L97; Q9BWY9; Q9BXF0; Q9H990; Q9NWU3; Q9P0C2; Q9UGD6"	""	""	"0"	"0"	"11.8"	"4.2"	"7.1"	"15.6"	"13.5"	"15.2"	"51.7"	"50.7"	"32.7"	"45.6"	"53.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6SPF0"	"Atherin OS=Homo sapiens OX=9606 GN=SAMD1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"538"	"56.0"	"7.58"	"264.81"	"2.38"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;nucleus;other cell component"	"other molecular function"	"Pf00536"	"90378"	"ENSG00000288488"	"SAMD1"	"hsa:90378; Q6P0R3; Q6PIS7; Q6SPF0; Q96IM4"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"P41223"	"Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2"	"20"	"2"	"3"	"2"	"144"	"17.0"	"8.82"	"876.67"	"2.38"	"2"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf01125"	"8896"	"ENSG00000106245"	"BUD31"	"A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"16.8"	"12.7"	"14.4"	"18.5"	"26.0"	"27.3"	"143.9"	"126.1"	"82.6"	"105.5"	"106.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7L0Y3"	"tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2"	"5"	"2"	"3"	"2"	"403"	"47.3"	"9.36"	"485.84"	"2.38"	"2"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01746"	"54931"	"ENSG00000174173"	"TRMT10C"	"hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596"	""	"tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion"	"3"	"0"	"29.8"	"23.8"	"26.4"	"46.5"	"59.4"	"53.3"	"187.7"	"192.3"	"126.1"	"139.1"	"195.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5QJE6"	"Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Homo sapiens OX=9606 GN=DNTTIP2 PE=1 SV=2"	"2"	"2"	"2"	"2"	"756"	"84.4"	"6.16"	"250.08"	"2.37"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf08698"	"30836"	"ENSG00000067334"	"DNTTIP2"	"hsa:30836; Q12987; Q53H59; Q5QJE6; Q5TFJ4; Q6TLI0; Q76MJ8; Q86WX9"	""	""	"0"	"0"	"17.0"	"9.0"	"13.9"	"20.1"	"24.6"	"22.8"	"55.5"	"52.1"	"25.6"	"37.6"	"46.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P50402"	"Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1"	"5"	"1"	"2"	"1"	"254"	"29.0"	"5.50"	"276.34"	"2.37"	"1"	"1"	"cell organization and biogenesis;other biological processes"	"other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"cytoskeletal activity"	"Pf03020"	"2010"	"ENSG00000102119"	"EMD"	"hsa:2010; P50402; Q6FI02"	"Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling"	"RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina"	"12"	"0"	"8.8"	"4.8"	"4.4"	"11.0"	"14.5"	"10.7"	"18.9"	"15.0"	"11.2"	"15.5"	"18.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35914"	"Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2"	"3"	"1"	"2"	"1"	"325"	"34.3"	"8.54"	"277.18"	"2.37"	"1"	"1"	"cell organization and biogenesis;other metabolic processes"	"cytosol;mitochondrion;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00682"	"3155"	"ENSG00000117305"	"HMGCL"	"B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8"	"Amino acid metabolism"	"Peroxisomal protein import; Synthesis of Ketone Bodies"	"3"	"0"	"4.2"	"6.9"	"7.0"	"9.4"	"11.4"	"13.8"	"16.9"	"18.9"	"14.1"	"15.9"	"12.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15560"	"Transcription elongation factor A protein 2 OS=Homo sapiens OX=9606 GN=TCEA2 PE=1 SV=1"	"4"	"1"	"2"	"1"	"299"	"33.6"	"9.13"	"302.07"	"2.37"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytoskeleton;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01096, Pf07500, Pf08711"	"6919"	"ENSG00000171703"	"TCEA2"	"B3KNM1; hsa:6919; Q15560; Q8TD37; Q8TD38"	""	""	"0"	"0"	"12.9"	"8.6"	"12.0"	"16.0"	"18.9"	"12.5"	"70.0"	"64.6"	"44.4"	"50.7"	"62.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N488"	"RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2"	"7"	"2"	"3"	"2"	"228"	"24.8"	"9.63"	"619.95"	"2.37"	"2"	"1"	"cell organization and biogenesis;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00641, Pf17219"	"23429"	"ENSG00000163602; ENSG00000281766"	"RYBP"	"hsa:23429; Q8N488; Q9P2W5; Q9UMW4"	""	"Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"	"2"	"0"	"143.0"	"75.1"	"141.9"	"210.3"	"228.7"	"211.1"	"826.9"	"881.5"	"416.8"	"490.0"	"740.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A3KMH1"	"von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1905"	"214.7"	"7.40"	"296.65"	"2.36"	"1"	"1"	""	"mitochondrion;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf07728"	"23078"	"ENSG00000102763"	"VWA8"	"A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5SW79"	"Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1"	"1"	"1"	"1"	"1"	"1584"	"175.2"	"7.11"	""	"2.35"	""	"1"	""	"cytosol;cytoskeleton;other cell component"	""	"Pf00498, Pf15308"	"9859"	"ENSG00000143702; ENSG00000276725"	"CEP170"	"hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09"	"Ciliary landscape"	""	"1"	"0"	"23.3"	"14.7"	"29.6"	"33.7"	"40.2"	"43.4"	"123.6"	"125.2"	"89.6"	"109.7"	"137.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75152"	"Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3"	"1"	"1"	"2"	"1"	"810"	"89.1"	"8.37"	"292.73"	"2.35"	"1"	"1"	"other metabolic processes;transport"	"nucleus"	"other molecular function"	"Pf15663"	"9877"	"ENSG00000058673"	"ZC3H11A"	"hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7"	""	"Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination"	"3"	"0"	"16.5"	"12.0"	"12.9"	"19.0"	"24.1"	"21.5"	"51.3"	"52.7"	"25.0"	"41.0"	"53.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5TC12"	"ATP synthase mitochondrial F1 complex assembly factor 1 OS=Homo sapiens OX=9606 GN=ATPAF1 PE=1 SV=1"	"4"	"1"	"1"	"1"	"328"	"36.4"	"7.96"	""	"2.35"	""	"1"	"cell organization and biogenesis"	"mitochondrion"	""	"Pf06644"	"64756"	"ENSG00000123472"	"ATPAF1"	"B1AQW7; B7Z7D6; B7Z7I6; hsa:64756; Q5TC12; Q9H6E3"	"7q11.23 copy number variation syndrome"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94905"	"Erlin-2 OS=Homo sapiens OX=9606 GN=ERLIN2 PE=1 SV=1"	"7"	"2"	"3"	"2"	"339"	"37.8"	"5.62"	"631.31"	"2.35"	"2"	"1"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"other molecular function"	"Pf01145"	"11160"	"ENSG00000147475"	"ERLIN2"	"A0JLQ1; A8K5S9; B4DM38; D3DSW0; hsa:11160; O94905; Q6NW21; Q86VS6; Q86W49"	""	"ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions"	"4"	"0"	"36.2"	"33.2"	"39.2"	"49.6"	"61.0"	"52.6"	"88.4"	"99.5"	"66.1"	"91.8"	"83.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51116"	"Fragile X mental retardation syndrome-related protein 2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2"	"1"	"1"	"2"	"1"	"673"	"74.2"	"6.23"	"276.64"	"2.34"	"1"	"1"	"developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00013, Pf05641, Pf12235, Pf16096, Pf17904, Pf18336"	"9513"	"ENSG00000129245"	"FXR2"	"B2R9M2; D3DTQ1; hsa:9513; P51116; Q86V09; Q8WUM2"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"48.2"	"41.7"	"57.7"	"75.3"	"98.0"	"97.1"	"239.5"	"241.3"	"180.1"	"192.5"	"194.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14258"	"E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2"	"2"	"1"	"1"	"1"	"630"	"70.9"	"8.09"	""	"2.34"	""	"1"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00622, Pf13445, Pf13765"	"7706"	"ENSG00000121060"	"TRIM25"	"hsa:7706; Q14258"	"Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome"	"SARS-CoV-1 activates/modulates innate immune responses; Termination of translesion DNA synthesis; ISG15 antiviral mechanism; Interferon gamma signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation"	"16"	"0"	"2.9"	"3.7"	"6.4"	"5.0"	"6.9"	"5.5"	"27.0"	"22.1"	"18.5"	"18.1"	"21.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NEZ5"	"F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1"	"2"	"1"	"2"	"1"	"403"	"44.5"	"7.03"	"333.40"	"2.34"	"1"	"1"	"protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"cytosol;cytoskeleton;nucleus"	"other molecular function"	"Pf00646, Pf10442"	"26263"	"ENSG00000167196"	"FBXO22"	"hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0"	""	"Antigen processing: Ubiquitination & Proteasome degradation; Neddylation"	"2"	"0"	"29.6"	"27.4"	"32.3"	"38.3"	"40.3"	"39.0"	"60.3"	"55.2"	"39.1"	"51.1"	"64.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99504"	"Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3"	"2"	"1"	"2"	"1"	"573"	"62.6"	"5.21"	"359.33"	"2.34"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"cytoskeleton;nucleus;other cell component"	"other molecular function"	""	"2140"	"ENSG00000158161"	"EYA3"	"A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813"	""	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"	"1"	"0"	"4.5"	"6.7"	"6.1"	"10.1"	"17.0"	"10.8"	"15.0"	"14.2"	"11.5"	"12.8"	"9.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BUK0"	"Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Homo sapiens OX=9606 GN=CHCHD7 PE=1 SV=1"	"11"	"1"	"2"	"1"	"85"	"10.1"	"8.82"	"296.93"	"2.34"	"1"	"1"	"cell organization and biogenesis"	"mitochondrion"	""	""	"79145"	"ENSG00000170791"	"CHCHD7"	"A8K223; E9PBH3; hsa:79145; J3KNE9; Q7Z588; Q9BUK0"	""	"Mitochondrial protein import"	"1"	"0"	"48.7"	"35.0"	"40.6"	"51.5"	"63.2"	"60.6"	"115.3"	"128.5"	"92.9"	"123.3"	"147.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13640"	"Metallothionein-1G OS=Homo sapiens OX=9606 GN=MT1G PE=1 SV=2"	"19"	"1"	"1"	"1"	"62"	"6.1"	"7.96"	""	"2.34"	""	"1"	"other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00131"	"4495"	"ENSG00000125144"	"MT1G"	"hsa:4495; P13640; P80296"	"Copper homeostasis; Zinc homeostasis"	"Metallothioneins bind metals"	"3"	"0"	"14.4"	"9.1"	"15.1"	"15.5"	"22.3"	"16.3"	"39.9"	"46.2"	"21.9"	"35.4"	"37.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86TV6"	"Tetratricopeptide repeat protein 7B OS=Homo sapiens OX=9606 GN=TTC7B PE=1 SV=3"	"1"	"1"	"2"	"1"	"843"	"94.1"	"6.89"	"248.20"	"2.34"	"1"	"1"	"other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol"	""	"Pf12895, Pf13181, Pf13424, Pf19440"	"145567"	"ENSG00000165914"	"TTC7B"	"hsa:145567; Q86TV6; Q86U24; Q86VT3"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22830"	"Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2"	"5"	"1"	"1"	"1"	"423"	"47.8"	"8.73"	""	"2.34"	""	"1"	"cell organization and biogenesis;other metabolic processes;other biological processes"	"other membranes;mitochondrion"	"nucleic acid binding activity;other molecular function"	"Pf00762"	"2235"	"ENSG00000066926"	"FECH"	"A8KA72; hsa:2235; P22830; Q8IXN1; Q8NAN0"	"Hemesynthesis defects and porphyrias; Heme biosynthesis"	"Heme biosynthesis"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P2E9"	"Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5"	"2"	"4"	"4"	"3"	"1410"	"152.4"	"8.60"	"1187.30"	"2.33"	"3"	"1"	"protein metabolism;other metabolic processes;transport"	"other membranes;ER/Golgi;translational apparatus"	"other molecular function"	"Pf05104"	"6238"	"ENSG00000125844"	"RRBP1"	"A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9"	"Ectoderm differentiation"	"Signaling by ALK fusions and activated point mutants"	"2"	"0"	"107.2"	"56.3"	"84.1"	"99.7"	"130.3"	"127.8"	"485.1"	"461.8"	"324.3"	"389.6"	"618.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92466"	"DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1"	"4"	"1"	"1"	"1"	"427"	"47.8"	"9.47"	""	"2.33"	""	"1"	"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00400"	"1643"	"ENSG00000134574"	"DDB2"	"B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466"	"miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response"	"Ub-specific processing proteases; Dual Incision in GG-NER; DNA Damage Recognition in GG-NER; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; Formation of Incision Complex in GG-NER"	"21"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N122"	"Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1"	"1"	"1"	"2"	"1"	"1335"	"148.9"	"6.89"	"246.68"	"2.33"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00400, Pf02985, Pf14538"	"57521"	"ENSG00000141564"	"RPTOR"	"B2RN36; C6KEF2; F5H7J5; hsa:57521; Q8N122; Q8N4V9; Q8TB32; Q9P2P3"	"AMP-activated protein kinase signaling; Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of Beta-cells; Interferon type I signaling pathways"	"Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Amino acids regulate mTORC1; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation"	"33"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4W6"	"AFG3-like protein 2 OS=Homo sapiens OX=9606 GN=AFG3L2 PE=1 SV=2"	"2"	"2"	"3"	"2"	"797"	"88.5"	"8.66"	"482.87"	"2.33"	"2"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes"	"other membranes;mitochondrion"	"other molecular function"	"Pf00004, Pf01434, Pf06480, Pf17862"	"10939"	"ENSG00000141385"	"AFG3L2"	"hsa:10939; Q6P1L0; Q9Y4W6"	"Ciliary landscape; 10q22q23 copy number variation"	"Processing of SMDT1"	"3"	"0"	"22.6"	"12.4"	"20.8"	"27.3"	"35.1"	"29.0"	"83.8"	"81.9"	"60.9"	"79.0"	"132.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86VP6"	"Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1230"	"136.3"	"5.78"	""	"2.33"	""	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf08623"	"55832"	"ENSG00000111530"	"CAND1"	"B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85"	"Endoderm differentiation"	"Neutrophil degranulation; Neddylation; Iron uptake and transport"	"4"	"0"	"6.5"	"2.9"	"7.7"	"7.3"	"9.1"	"9.3"	"18.3"	"20.5"	"12.1"	"21.8"	"27.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75446"	"Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1"	"5"	"1"	"2"	"1"	"220"	"23.3"	"9.17"	"247.55"	"2.32"	"1"	"1"	"other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf13866, Pf13867"	"8819"	"ENSG00000164105"	"SAP30"	"D3DP38; hsa:8819; O75446"	"Retinoblastoma gene in cancer; Notch signaling pathway"	"HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Potential therapeutics for SARS"	"5"	"0"	"6.0"	"7.1"	"7.7"	"11.1"	"14.3"	"16.0"	"40.4"	"39.7"	"21.9"	"38.1"	"52.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BTT6"	"Leucine-rich repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRRC1 PE=1 SV=1"	"2"	"1"	"2"	"1"	"524"	"59.2"	"5.02"	"246.10"	"2.32"	"1"	"1"	""	"other membranes;cytosol"	""	"Pf13855"	"55227"	"ENSG00000137269"	"LRRC1"	"hsa:55227; Q5TGN3; Q9BTT6; Q9HAC0; Q9NVF1"	""	"RND2 GTPase cycle"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75691"	"Small subunit processome component 20 homolog OS=Homo sapiens OX=9606 GN=UTP20 PE=1 SV=3"	"1"	"1"	"1"	"1"	"2785"	"318.2"	"7.39"	""	"2.31"	""	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	""	"Pf07539, Pf20416"	"27340"	"ENSG00000120800"	"UTP20"	"hsa:27340; O75691; Q9H3H4"	""	"rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol"	"2"	"0"	"15.6"	"6.1"	"12.7"	"25.7"	"38.1"	"21.4"	"92.9"	"68.9"	"7.9"	"36.3"	"66.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IYB5"	"Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2"	"2"	"1"	"1"	"1"	"467"	"50.4"	"8.75"	""	"2.31"	""	"1"	"other biological processes"	"plasma membrane;other membranes;other cell component"	"enzyme regulator activity;other molecular function"	"Pf01412"	"60682"	"ENSG00000112305"	"SMAP1"	"hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NYB0"	"Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1"	"2"	"1"	"1"	"1"	"399"	"44.2"	"4.73"	""	"2.31"	""	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf08914, Pf11626, Pf16589"	"54386"	"ENSG00000166848"	"TERF2IP"	"B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0"	"Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction"	"DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Polymerase switching on the C-strand of the telomere; Removal of the Flap Intermediate from the C-strand; Telomere Extension By Telomerase; Telomere C-strand synthesis initiation"	"16"	"0"	"40.7"	"38.0"	"42.2"	"60.2"	"85.8"	"56.6"	"157.2"	"166.9"	"102.5"	"127.7"	"152.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UM13"	"Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1"	"6"	"1"	"1"	"1"	"185"	"21.2"	"9.06"	""	"2.31"	""	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus"	""	"Pf03256"	"10393"	"ENSG00000164162"	"ANAPC10"	"D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0"	"Cell cycle"	"Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects"	"19"	"0"	"5.8"	"5.5"	"11.0"	"18.5"	"15.9"	"15.7"	"42.6"	"33.7"	"28.1"	"45.4"	"66.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZL9"	"Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1"	"4"	"1"	"2"	"1"	"334"	"37.5"	"7.36"	"443.77"	"2.31"	"1"	"1"	"other metabolic processes"	"cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf04321"	"27430"	"ENSG00000038274"	"MAT2B"	"B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54"	"Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Methylation pathways"	"Ub-specific processing proteases; Methylation"	"7"	"0"	"26.4"	"24.9"	"23.8"	"31.4"	"37.7"	"37.8"	"54.4"	"56.8"	"44.1"	"46.3"	"78.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13232"	"Nucleoside diphosphate kinase 3 OS=Homo sapiens OX=9606 GN=NME3 PE=1 SV=2"	"7"	"1"	"2"	"1"	"169"	"19.0"	"7.84"	"345.39"	"2.31"	"1"	"1"	"other metabolic processes;other biological processes"	"cytosol"	"kinase activity;other molecular function"	"Pf00334"	"4832"	"ENSG00000103024"	"NME3"	"hsa:4832; Q13232; Q9BWH4"	"Pyrimidine metabolism"	"Interconversion of nucleotide di- and triphosphates"	"2"	"0"	"23.5"	"18.4"	"35.6"	"51.4"	"58.7"	"47.4"	"103.8"	"87.2"	"45.5"	"79.2"	"126.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P43034"	"Platelet-activating factor acetylhydrolase IB subunit alpha OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2"	"3"	"2"	"5"	"1"	"410"	"46.6"	"7.37"	"1010.30"	"2.31"	"2"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00400, Pf08513"	"5048"	"ENSG00000007168"	"PAFAH1B1"	"B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89"	"Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"	"18"	"0"	"68.2"	"49.2"	"61.9"	"92.0"	"113.4"	"114.2"	"325.5"	"346.4"	"222.3"	"321.4"	"444.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q2KHT3"	"Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2"	"1"	"1"	"2"	"1"	"1053"	"117.6"	"5.86"	"238.39"	"2.30"	"1"	"1"	"other metabolic processes;stress response;transport;other biological processes"	"other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component"	""	"Pf09758, Pf19439"	"23274"	"ENSG00000038532"	"CLEC16A"	"hsa:23274; O15058; Q2KHT3; Q6ZTB2"	"Vitamin D receptor pathway"	""	"1"	"0"	"95.8"	"51.5"	"88.1"	"116.3"	"147.0"	"117.6"	"300.9"	"293.4"	"176.7"	"233.6"	"361.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O96033"	"Molybdopterin synthase sulfur carrier subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1"	"13"	"1"	"1"	"1"	"88"	"9.7"	"4.72"	""	"2.30"	""	"1"	"protein metabolism;other metabolic processes"	"cytosol;other cell component"	"other molecular function"	"Pf02597"	"4338"	"ENSG00000164172"	"MOCS2"	"O96033"	"Metabolic Epileptic Disorders"	"Molybdenum cofactor biosynthesis"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51665"	"26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2"	"3"	"1"	"1"	"1"	"324"	"37.0"	"6.77"	""	"2.30"	""	"1"	"protein metabolism;other metabolic processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"other molecular function"	"Pf01398, Pf13012"	"5713"	"ENSG00000103035"	"PSMD7"	"D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease"	"Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"65"	"0"	"6.1"	"7.4"	"12.5"	"10.4"	"12.1"	"15.4"	"39.0"	"27.9"	"18.3"	"20.1"	"29.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92696"	"Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2"	"2"	"1"	"2"	"1"	"567"	"65.0"	"5.67"	"258.73"	"2.30"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	"Pf01239, Pf07711"	"5875"	"ENSG00000100949; ENSG00000285193"	"RABGGTA"	"A8K5N2; D3DS69; hsa:5875; Q92696"	""	"RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6W3E5"	"Glycerophosphodiester phosphodiesterase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GDPD4 PE=2 SV=1"	"3"	"1"	"1"	"1"	"623"	"71.9"	"9.03"	""	"2.30"	""	"1"	"other metabolic processes"	"other membranes"	"other molecular function"	"Pf03009"	"220032"	"ENSG00000178795"	"GDPD4"	"hsa:220032; Q6W3E5; Q7Z5B0"	""	""	"0"	"0"	"44.3"	"14.9"	"30.3"	"30.9"	"51.2"	"40.5"	"99.4"	"81.3"	"44.4"	"68.1"	"113.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86YV5"	"Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4"	"1"	"1"	"1"	"1"	"1406"	"149.5"	"7.20"	""	"2.29"	""	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"157285"	"ENSG00000275342"	"PRAG1"	"hsa:157285; Q86YV5; Q8N3N5"	""	"RND2 GTPase cycle"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z7F7"	"39S ribosomal protein L55, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL55 PE=1 SV=1"	"6"	"1"	"2"	"1"	"128"	"15.1"	"11.15"	"333.47"	"2.29"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;other cell component"	"other molecular function"	"Pf09776"	"128308"	"ENSG00000162910"	"MRPL55"	"hsa:128308; Q5TBY3; Q5TBY6; Q6UWI8; Q7Z7F7"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"26.5"	"23.1"	"35.6"	"47.3"	"53.5"	"42.7"	"114.4"	"108.9"	"84.2"	"103.6"	"138.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18074"	"General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1"	"1"	"1"	"2"	"1"	"760"	"86.9"	"7.15"	"262.55"	"2.29"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf06733, Pf06777, Pf13307"	"2068"	"ENSG00000104884"	"ERCC2"	"hsa:2068; P18074; Q2TB78; Q2YDY2; Q7KZU6; Q8N721"	"Fluoropyrimidine activity; Eukaryotic transcription initiation; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Cytosolic iron-sulfur cluster assembly; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER"	"36"	"0"	"10.5"	"7.2"	"14.5"	"13.8"	"16.0"	"17.3"	"27.1"	"34.1"	"22.0"	"30.3"	"39.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43617"	"Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1"	"4"	"1"	"2"	"1"	"180"	"20.3"	"4.96"	"291.96"	"2.29"	"1"	"1"	"cell organization and biogenesis;transport"	"other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component"	""	"Pf04051"	"27095"	"ENSG00000054116"	"TRAPPC3"	"A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617"	""	"RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport"	"2"	"0"	"27.5"	"16.6"	"30.8"	"38.8"	"44.3"	"39.7"	"82.2"	"79.5"	"67.3"	"82.9"	"110.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q00796"	"Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4"	"2"	"1"	"2"	"1"	"357"	"38.3"	"7.97"	"240.17"	"2.29"	"1"	"1"	"other metabolic processes;stress response;other biological processes"	"non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion"	"other molecular function"	"Pf00107, Pf08240"	"6652"	"ENSG00000140263"	"SORD"	"B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6"	"Disorders of fructose metabolism; Polyol pathway"	"Formation of xylulose-5-phosphate; Fructose biosynthesis"	"4"	"0"	"35.0"	"24.7"	"38.4"	"42.6"	"59.4"	"60.6"	"127.4"	"153.7"	"114.9"	"126.8"	"264.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15024"	"Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3"	"2"	"1"	"2"	"1"	"291"	"31.8"	"5.19"	"253.27"	"2.28"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01138, Pf03725"	"23016"	"ENSG00000075914"	"EXOSC7"	"hsa:23016; Q15024; Q96E72"	"Ciliary landscape"	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"7"	"0"	"66.5"	"38.5"	"58.1"	"75.6"	"93.3"	"99.3"	"260.4"	"250.8"	"138.3"	"184.1"	"245.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02880"	"DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3"	"1"	"1"	"1"	"1"	"1626"	"183.2"	"8.00"	""	"2.28"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898"	"7155"	"ENSG00000077097"	"TOP2B"	"hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8"	""	"SUMOylation of DNA replication proteins"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15014"	"Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1"	"3"	"1"	"2"	"1"	"288"	"32.3"	"9.72"	"290.72"	"2.28"	"1"	"1"	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	""	"Pf05712"	"9643"	"ENSG00000123562"	"MORF4L2"	"B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026"	""	"HATs acetylate histones"	"1"	"0"	"30.4"	"18.8"	"31.5"	"43.0"	"62.1"	"45.5"	"259.1"	"267.3"	"140.9"	"202.6"	"221.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13619"	"Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3"	"2"	"2"	"3"	"2"	"759"	"87.6"	"8.13"	"578.66"	"2.28"	"2"	"1"	"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00888, Pf10557"	"8451"	"ENSG00000139842"	"CUL4A"	"A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17"	"Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum"	"Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER"	"13"	"0"	"34.7"	"31.6"	"39.5"	"52.1"	"63.9"	"62.4"	"107.9"	"113.8"	"78.9"	"101.7"	"209.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20929"	"Nebulin OS=Homo sapiens OX=9606 GN=NEB PE=1 SV=5"	"0"	"1"	"1"	"1"	"6669"	"772.4"	"9.07"	""	"2.28"	""	"1"	"cell organization and biogenesis;developmental processes;other biological processes"	"cytosol;cytoskeleton"	"cytoskeletal activity;other molecular function"	"Pf00880, Pf14604"	"4703"	"ENSG00000183091"	"NEB"	"F8WCL5; F8WCP0; hsa:4703; P20929; Q15346; Q53QQ2; Q53TG8"	"Striated muscle contraction pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling"	"Striated Muscle Contraction"	"3"	"0"	"59.7"	"31.6"	"46.8"	"67.5"	"78.9"	"62.7"	"144.0"	"149.2"	"97.7"	"140.6"	"194.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6UB35"	"Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1"	"2"	"1"	"1"	"1"	"978"	"105.7"	"8.06"	""	"2.27"	""	"1"	"other metabolic processes;developmental processes"	"cytosol;mitochondrion"	"other molecular function"	"Pf00763, Pf01268, Pf02882"	"25902"	"ENSG00000120254"	"MTHFD1L"	"hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8"	"One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways"	"Metabolism of folate and pterines"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P43155"	"Carnitine O-acetyltransferase OS=Homo sapiens OX=9606 GN=CRAT PE=1 SV=5"	"4"	"2"	"2"	"2"	"626"	"70.8"	"8.44"	"248.20"	"2.27"	"1"	"1"	"other metabolic processes"	"other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle"	"other molecular function"	"Pf00755"	"1384"	"ENSG00000095321"	"CRAT"	"P43155; Q5T952; Q9BW16"	"Fatty acid beta-oxidation"	"Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA"	"3"	"0"	"36.3"	"30.1"	"37.6"	"47.6"	"70.1"	"71.0"	"245.8"	"238.3"	"208.2"	"256.2"	"445.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60563"	"Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1"	"1"	"1"	"2"	"1"	"726"	"80.6"	"8.78"	"379.46"	"2.27"	"1"	"1"	"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"enzyme regulator activity;nucleic acid binding activity;other molecular function"	"Pf00134"	"904"	"ENSG00000129315"	"CCNT1"	"A9XU13; E7EX76; hsa:904; O60563; O60581"	"Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility"	"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins"	"17"	"0"	"41.1"	"26.6"	"35.8"	"40.6"	"66.9"	"52.4"	"235.4"	"274.0"	"195.5"	"359.2"	"548.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P19404"	"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2"	"4"	"1"	"2"	"1"	"249"	"27.4"	"8.06"	"274.30"	"2.26"	"1"	"1"	"other metabolic processes;transport;developmental processes"	"other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf01257"	"4729"	"ENSG00000178127"	"NDUFV2"	"hsa:4729; P19404; Q9BV41"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Complex I biogenesis"	"5"	"0"	"4.3"	"0.0"	"5.3"	"8.5"	"7.6"	"5.1"	"22.2"	"18.5"	"8.2"	"12.7"	"19.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TDJ6"	"DmX-like protein 2 OS=Homo sapiens OX=9606 GN=DMXL2 PE=1 SV=2"	"0"	"1"	"1"	"1"	"3036"	"339.4"	"6.38"	""	"2.26"	""	"1"	"other biological processes"	"other membranes;ER/Golgi;other cell component"	"other molecular function"	"Pf00400, Pf12234"	"23312"	"ENSG00000104093"	"DMXL2"	"B2RTR3; B7ZMH3; F5GWF1; hsa:23312; O94938; Q8TDJ6"	""	""	"0"	"0"	"12.0"	"5.2"	"8.8"	"15.2"	"23.0"	"12.7"	"109.9"	"118.3"	"27.3"	"38.3"	"69.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZM3"	"Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3"	"1"	"1"	"2"	"1"	"1697"	"193.3"	"8.12"	"251.13"	"2.25"	"1"	"1"	"transport;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652"	"50618"	"ENSG00000198399"	"ITSN2"	"hsa:50618; O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4"	""	"Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NZI7"	"Upstream-binding protein 1 OS=Homo sapiens OX=9606 GN=UBP1 PE=1 SV=1"	"2"	"1"	"1"	"1"	"540"	"60.5"	"6.35"	""	"2.25"	""	"1"	"developmental processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf04516, Pf18016"	"7342"	"ENSG00000153560"	"UBP1"	"hsa:7342; Q68CT0; Q86Y57; Q9H8V0; Q9NZI7; Q9UD76; Q9UD78"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRJ2"	"39S ribosomal protein L45, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2"	"3"	"1"	"1"	"1"	"306"	"35.3"	"9.03"	""	"2.25"	""	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	""	"Pf04280"	""	"ENSG00000277936"	"MRPL45"	"A1L436; Q6ZMJ5; Q9BRJ2"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"8.8"	"6.3"	"7.4"	"9.1"	"14.7"	"7.8"	"30.1"	"33.1"	"21.8"	"22.4"	"35.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NYK5"	"39S ribosomal protein L39, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3"	"3"	"1"	"1"	"1"	"338"	"38.7"	"7.65"	""	"2.25"	""	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	""	"54148"	"ENSG00000154719"	"MRPL39"	"C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5EBL8"	"PDZ domain-containing protein 11 OS=Homo sapiens OX=9606 GN=PDZD11 PE=1 SV=2"	"20"	"3"	"4"	"2"	"140"	"16.1"	"7.21"	"895.51"	"2.25"	"3"	"1"	"cell-cell signaling;cell organization and biogenesis;transport;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component"	""	"Pf00595"	"51248"	"ENSG00000120509"	"PDZD11"	"D3DVU3; hsa:51248; Q5EBL8; Q6UWE1; Q9P0Q1"	""	"Ion transport by P-type ATPases; Ion influx/efflux at host-pathogen interface; Transport of vitamins, nucleosides, and related molecules; Biotin transport and metabolism; Vitamin B5 (pantothenate) metabolism"	"5"	"0"	"43.2"	"35.4"	"40.6"	"50.1"	"67.6"	"59.5"	"128.8"	"127.5"	"106.3"	"128.4"	"191.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78346"	"Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1"	"4"	"1"	"1"	"1"	"268"	"29.3"	"8.91"	""	"2.25"	""	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01876"	"10556"	"ENSG00000148688"	"RPP30"	"B2R799; E9PB02; hsa:10556; P78346"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus"	"2"	"0"	"4.6"	"0.0"	"4.8"	"5.6"	"3.3"	"4.6"	"25.4"	"18.8"	"10.1"	"19.2"	"29.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P22033"	"Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4"	"1"	"1"	"2"	"1"	"750"	"83.1"	"6.93"	"257.78"	"2.24"	"1"	"1"	"other metabolic processes;developmental processes;other biological processes"	"mitochondrion;other cell component"	"other molecular function"	"Pf01642, Pf02310"	"4594"	"ENSG00000146085"	"MMUT"	"A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64"	"Vitamin B12 metabolism; Amino acid metabolism"	"Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism"	"6"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P35613"	"Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2"	"2"	"1"	"1"	"1"	"385"	"42.2"	"5.66"	""	"2.24"	""	"1"	"developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf13927"	"682"	"ENSG00000172270"	"BSG"	"A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7"	"Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway"	"Degradation of the extracellular matrix; Integrin cell surface interactions; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)"	"10"	"0"	"33.2"	"25.6"	"22.7"	"30.8"	"46.1"	"38.4"	"71.4"	"82.5"	"38.6"	"88.5"	"71.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IWJ2"	"GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4"	"0"	"1"	"2"	"1"	"1684"	"195.8"	"5.14"	"315.83"	"2.24"	"1"	"1"	"cell organization and biogenesis;transport;other biological processes"	"cytosol;ER/Golgi;nucleus"	"other molecular function"	"Pf01465, Pf16704"	"9648"	"ENSG00000135968"	"GCC2"	"A6H8X8; hsa:9648; O15045; Q4ZG46; Q8IWJ2; Q8TDH3; Q9H2G8"	"Deregulation of Rab and Rab effector genes in bladder cancer"	"Signaling by ALK fusions and activated point mutants; Retrograde transport at the Trans-Golgi-Network"	"3"	"0"	"20.4"	"11.3"	"19.1"	"20.8"	"27.2"	"32.3"	"71.7"	"63.2"	"37.2"	"56.1"	"76.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6NSJ5"	"Volume-regulated anion channel subunit LRRC8E OS=Homo sapiens OX=9606 GN=LRRC8E PE=1 SV=2"	"3"	"1"	"1"	"1"	"796"	"90.2"	"6.96"	""	"2.24"	""	"1"	"cell organization and biogenesis;stress response;transport"	"plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component"	"transporter activity"	"Pf12534, Pf13855"	"80131"	"ENSG00000171017"	"LRRC8E"	"B3KR78; hsa:80131; Q2YDY3; Q6NSJ5; Q7L236; Q8N3B0; Q9H5H8"	"Neuroinflammation and glutamatergic signaling"	"Miscellaneous transport and binding events"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P27824"	"Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2"	"4"	"2"	"3"	"2"	"592"	"67.5"	"4.60"	"767.08"	"2.23"	"2"	"1"	"protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"plasma membrane;other membranes;ER/Golgi;translational apparatus;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00262"	"821"	"ENSG00000127022; ENSG00000283777"	"CANX"	"B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824"	"15q11q13 copy number variation"	"Maturation of spike protein; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Calnexin/calreticulin cycle; Maturation of spike protein"	"9"	"0"	"134.5"	"64.5"	"111.2"	"140.6"	"201.6"	"175.6"	"281.1"	"239.3"	"104.6"	"241.0"	"276.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13526"	"Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1"	"5"	"1"	"2"	"1"	"163"	"18.2"	"8.82"	"288.10"	"2.23"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00397, Pf00639"	"5300"	"ENSG00000127445"	"PIN1"	"A8K4V9; hsa:5300; Q13526; Q53X75"	"Novel intracellular components of RIG-I-like receptor pathway"	"ISG15 antiviral mechanism; RHO GTPases Activate NADPH Oxidases; Regulation of TP53 Activity through Phosphorylation; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation"	"6"	"0"	"77.0"	"45.7"	"59.8"	"90.4"	"123.4"	"96.2"	"321.2"	"313.5"	"176.4"	"243.3"	"388.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75340"	"Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1"	"5"	"1"	"2"	"1"	"191"	"21.9"	"5.40"	"351.05"	"2.23"	"1"	"1"	"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf13202, Pf13499"	"10016"	"ENSG00000249915"	"PDCD6"	"B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0"	"Epithelial to mesenchymal transition in colorectal cancer"	""	"1"	"0"	"36.8"	"31.6"	"37.0"	"65.1"	"80.7"	"52.2"	"106.5"	"102.6"	"74.7"	"98.2"	"119.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WVK2"	"U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP27 PE=1 SV=1"	"7"	"1"	"1"	"1"	"155"	"18.8"	"11.62"	""	"2.22"	""	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf08648"	"11017"	"ENSG00000124380"	"SNRNP27"	"hsa:11017; Q15410; Q8WVK2"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"8.0"	"2.4"	"5.5"	"6.2"	"11.1"	"7.2"	"20.5"	"19.2"	"9.9"	"14.3"	"21.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q4U2R6"	"39S ribosomal protein L51, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL51 PE=1 SV=1"	"9"	"1"	"2"	"1"	"128"	"15.1"	"11.27"	"271.37"	"2.22"	"1"	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf10244"	"51258"	"ENSG00000111639"	"MRPL51"	"hsa:51258; Q4U2R6; Q96Q57; Q9BQ36; Q9P0N7"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"2.2"	"4.3"	"5.2"	"4.7"	"5.6"	"5.5"	"21.2"	"23.0"	"8.3"	"15.0"	"17.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9ULH0"	"Kinase D-interacting substrate of 220 kDa OS=Homo sapiens OX=9606 GN=KIDINS220 PE=1 SV=3"	"1"	"1"	"1"	"1"	"1771"	"196.4"	"6.62"	""	"2.22"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"cytosol;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf07693, Pf12796"	"57498"	"ENSG00000134313"	"KIDINS220"	"A1L4N4; hsa:57498; Q4VC08; Q6MZU2; Q9H889; Q9H9E4; Q9NT37; Q9UF42; Q9ULH0"	"Brain-derived neurotrophic factor (BDNF) signaling pathway; Neural crest cell migration in cancer"	"RND1 GTPase cycle; RND2 GTPase cycle; ARMS-mediated activation"	"5"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4P3"	"Transducin beta-like protein 2 OS=Homo sapiens OX=9606 GN=TBL2 PE=1 SV=1"	"3"	"1"	"1"	"1"	"447"	"49.8"	"9.44"	""	"2.22"	""	"1"	"stress response;signal transduction"	"other membranes;ER/Golgi"	"other molecular function"	"Pf00400"	"26608"	"ENSG00000106638"	"TBL2"	"hsa:26608; Q9UQE2; Q9Y4P3"	"7q11.23 copy number variation syndrome"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P20585"	"DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4"	"2"	"2"	"2"	"2"	"1137"	"127.3"	"8.02"	"295.04"	"2.21"	"1"	"1"	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00488, Pf01624, Pf05188, Pf05192"	"4437"	"ENSG00000113318"	"MSH3"	"A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867"	"Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network"	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2"	"5"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q32P41"	"tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=2"	"2"	"1"	"1"	"1"	"509"	"58.2"	"8.62"	""	"2.21"	""	"1"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"40.9"	"19.8"	"36.6"	"45.5"	"49.4"	"57.7"	"215.1"	"176.4"	"103.0"	"139.9"	"237.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O94827"	"Pleckstrin homology domain-containing family G member 5 OS=Homo sapiens OX=9606 GN=PLEKHG5 PE=1 SV=3"	"1"	"1"	"1"	"1"	"1062"	"117.4"	"6.30"	""	"2.21"	""	"1"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"31.8"	"29.0"	"31.6"	"41.3"	"57.6"	"51.1"	"126.8"	"139.0"	"84.7"	"108.6"	"149.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60313"	"Dynamin-like 120 kDa protein, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3"	"1"	"1"	"1"	"1"	"960"	"111.6"	"7.87"	""	"2.21"	""	"1"	"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes"	"other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00350, Pf19434"	"4976"	"ENSG00000198836"	"OPA1"	"D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313"	"Orexin receptor pathway"	"Regulation of Apoptosis"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15398"	"Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2"	"1"	"1"	"2"	"1"	"846"	"95.1"	"9.00"	"248.62"	"2.21"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity"	"Pf03359"	"9787"	"ENSG00000126787"	"DLGAP5"	"A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58"	"Complement system in neuronal development and plasticity"	"NOTCH3 Intracellular Domain Regulates Transcription"	"2"	"0"	"15.8"	"11.6"	"16.4"	"29.2"	"26.1"	"24.8"	"65.0"	"59.9"	"47.2"	"53.8"	"66.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P53041"	"Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1"	"2"	"1"	"2"	"1"	"499"	"56.8"	"6.28"	"390.08"	"2.21"	"1"	"1"	"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00149, Pf00515, Pf08321"	"5536"	"ENSG00000011485"	"PPP5C"	"hsa:5536; P53041; Q16722; Q53XV2"	"MAPK signaling pathway; ATM signaling in development and disease"	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling"	"5"	"0"	"18.3"	"13.0"	"14.4"	"20.7"	"24.9"	"27.2"	"55.8"	"50.5"	"43.7"	"61.4"	"121.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14324"	"Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4"	"2"	"1"	"2"	"1"	"419"	"48.2"	"6.15"	"242.89"	"2.21"	"1"	"1"	"other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00348"	"2224"	"ENSG00000160752"	"FDPS"	"D3DV91; E9PCI9; hsa:2224; P14324; Q96G29"	"Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism"	"Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis"	"9"	"0"	"8.1"	"6.3"	"9.0"	"10.4"	"13.4"	"10.3"	"15.8"	"17.8"	"13.8"	"16.8"	"33.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2R9"	"28S ribosomal protein S7, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2"	"5"	"1"	"1"	"1"	"242"	"28.1"	"9.99"	""	"2.20"	""	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"nucleic acid binding activity;other molecular function"	"Pf00177"	"51081"	"ENSG00000125445"	"MRPS7"	"B2R9N5; hsa:51081; Q53GD6; Q9Y2R9"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51572"	"B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3"	"4"	"1"	"2"	"1"	"246"	"28.0"	"8.44"	"327.06"	"2.20"	"1"	"1"	"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf05529, Pf18035"	"10134"	"ENSG00000185825"	"BCAP31"	"B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0"	""	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins"	"4"	"0"	"61.0"	"36.8"	"57.6"	"73.2"	"87.6"	"82.6"	"199.2"	"185.0"	"103.0"	"158.7"	"258.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5VTR2"	"E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2"	"1"	"1"	"2"	"1"	"975"	"113.6"	"5.94"	"237.41"	"2.20"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00097"	"56254"	"ENSG00000155827"	"RNF20"	"A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83"	"ATM signaling in development and disease"	"E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60733"	"85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2"	"1"	"1"	"1"	"1"	"806"	"89.8"	"7.27"	""	"2.20"	""	"1"	"other metabolic processes;stress response;transport;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component"	"other molecular function"	"Pf00023, Pf01734"	"8398"	"ENSG00000184381"	"PLA2G6"	"A8K597; B0QYE8; hsa:8398; O60733; O75645; Q8N452; Q9UG29; Q9UIT0; Q9Y671"	"Spinal cord injury; Ras signaling; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Eicosanoid metabolism via cyclooxygenases (COX); Omega-3 / omega-6 fatty acid synthesis; Lipid metabolism in senescent cells"	"Role of phospholipids in phagocytosis; COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodeling of CL"	"11"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96RT1"	"Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2"	"1"	"1"	"2"	"1"	"1412"	"158.2"	"5.50"	"283.52"	"2.19"	"1"	"1"	"cell adhesion;cell organization and biogenesis;transport;signal transduction;other biological processes"	"extracellular matrix;plasma membrane;other membranes;nucleus;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity"	"Pf00595, Pf13855"	"55914"	"ENSG00000112851"	"ERBIN"	"A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5"	"Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma"	"RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; RHOG GTPase cycle; Downregulation of ERBB2 signaling; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants"	"26"	"0"	"6.1"	"2.9"	"5.5"	"12.7"	"17.1"	"11.0"	"26.2"	"25.7"	"18.5"	"22.7"	"38.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBB4"	"Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1"	"1"	"1"	"2"	"1"	"475"	"53.5"	"5.25"	"290.77"	"2.19"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes"	"plasma membrane;other membranes;cytosol;other cell component"	""	"Pf09759"	"25814"	"ENSG00000130638"	"ATXN10"	"A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4"	"Ciliopathies"	""	"1"	"0"	"15.6"	"10.2"	"11.2"	"18.1"	"19.5"	"26.3"	"43.1"	"39.3"	"21.3"	"36.2"	"45.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P53803"	"DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1"	"10"	"1"	"1"	"1"	"58"	"7.0"	"9.06"	""	"2.19"	""	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf03604"	"5440"	"ENSG00000147669"	"POLR2K"	"hsa:5440; P53803; Q6IBD4"	"Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome"	"Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; Cytosolic sensors of pathogen-associated DNA ; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere"	"57"	"0"	"52.2"	"39.5"	"54.7"	"69.7"	"90.3"	"66.2"	"200.6"	"248.1"	"210.7"	"282.6"	"374.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UJS0"	"Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens OX=9606 GN=SLC25A13 PE=1 SV=2"	"2"	"1"	"2"	"1"	"675"	"74.1"	"8.62"	"273.58"	"2.19"	"1"	"1"	"other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;mitochondrion"	"transporter activity;other molecular function"	"Pf00153"	"10165"	"ENSG00000004864"	"SLC25A13"	"hsa:10165; O14566; O14575; Q546F9; Q9NZW1; Q9UJS0; Q9UNI7"	""	"Gluconeogenesis; Mitochondrial protein import; Aspartate and asparagine metabolism"	"3"	"0"	"8.8"	"5.8"	"9.7"	"20.7"	"15.0"	"16.2"	"25.4"	"27.6"	"11.6"	"22.9"	"31.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75554"	"WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1"	"3"	"1"	"2"	"1"	"376"	"42.5"	"5.57"	"282.12"	"2.19"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00397, Pf06220"	"11193"	"ENSG00000120688"	"WBP4"	"B7Z4M2; hsa:11193; O75554; Q32P29"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q6UB99"	"Ankyrin repeat domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ANKRD11 PE=1 SV=3"	"0"	"1"	"2"	"1"	"2663"	"297.7"	"7.11"	"259.18"	"2.18"	"1"	"1"	"developmental processes;other biological processes"	"cytosol;nucleus"	""	"Pf12796"	"29123"	"ENSG00000167522"	"ANKRD11"	"hsa:29123; Q6NTG1; Q6QMF8; Q6UB99"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62333"	"26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1"	"4"	"1"	"2"	"1"	"389"	"44.1"	"7.49"	"384.59"	"2.18"	"1"	"1"	"protein metabolism;other metabolic processes;stress response;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00004, Pf16450, Pf17862"	"5706"	"ENSG00000100519"	"PSMC6"	"B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524"	"Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease"	"Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways"	"65"	"0"	"20.8"	"10.7"	"19.5"	"26.1"	"36.6"	"28.9"	"65.0"	"72.4"	"33.1"	"58.4"	"73.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P46937"	"Transcriptional coactivator YAP1 OS=Homo sapiens OX=9606 GN=YAP1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"504"	"54.4"	"5.17"	"296.70"	"2.18"	"1"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes"	"other membranes;cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00397"	"10413"	"ENSG00000137693"	"YAP1"	"B4DTY1; B7ZA01; E3WEB5; E3WEB6; E9PRV2; F5H202; hsa:10413; K0KQ18; K0KYZ8; K0L195; K0L1G3; P46937; Q7Z574; Q8IUY9"	"Mesodermal commitment pathway; Mesodermal commitment pathway; RAC1/PAK1/p38/MMP2 pathway; miR-509-3p alteration of YAP1/ECM axis; Ciliary landscape; Leukocyte-intrinsic Hippo pathway functions; Netrin-UNC5B signaling pathway; Galanin receptor pathway; Pleural mesothelioma"	"Nuclear signaling by ERBB4; RUNX2 regulates osteoblast differentiation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of axial mesoderm; Signaling by Hippo; YAP1- and WWTR1 (TAZ)-stimulated gene expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; RUNX3 regulates YAP1-mediated transcription"	"17"	"0"	"31.3"	"25.8"	"41.7"	"56.2"	"64.9"	"55.4"	"122.7"	"120.4"	"69.7"	"100.9"	"114.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04181"	"Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1"	"4"	"1"	"2"	"1"	"439"	"48.5"	"7.03"	"249.97"	"2.18"	"1"	"1"	"other metabolic processes;other biological processes"	"mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00202"	"4942"	"ENSG00000065154"	"OAT"	"D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03"	"Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway"	"Glutamate and glutamine metabolism"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P38935"	"DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3"	"1"	"1"	"1"	"1"	"993"	"109.1"	"8.97"	""	"2.18"	""	"1"	"cell organization and biogenesis;RNA metabolism OR transcription"	"nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf01424, Pf01428, Pf13086, Pf13087"	"3508"	"ENSG00000132740"	"IGHMBP2"	"A0PJD2; hsa:3508; P38935; Q00443; Q14177"	""	""	"0"	"0"	"23.7"	"15.5"	"22.8"	"29.1"	"33.5"	"29.2"	"106.4"	"106.4"	"81.9"	"103.9"	"193.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TBB5"	"Kelch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KLHDC4 PE=1 SV=1"	"2"	"1"	"1"	"1"	"520"	"57.9"	"5.72"	""	"2.18"	""	"1"	""	""	""	"Pf07646, Pf13418, Pf13854, Pf13964"	"54758"	"ENSG00000104731"	"KLHDC4"	"D3DUN3; D3DUN4; D3DUN5; hsa:54758; Q8TBB5; Q96F29; Q9BVN3"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z2W9"	"39S ribosomal protein L21, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2"	"5"	"1"	"1"	"1"	"205"	"22.8"	"9.89"	""	"2.17"	""	"1"	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf00829"	"219927"	"ENSG00000197345"	"MRPL21"	"A6NKU0; C9JPR2; hsa:219927; Q7Z2W9"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q93008"	"Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=3"	"0"	"1"	"1"	"1"	"2570"	"292.1"	"5.80"	""	"2.17"	""	"1"	"protein metabolism;other metabolic processes"	""	"other molecular function"	"Pf00443, Pf12030"	"100971796; 465582"	"ENSPPAG00000039671; ENSPTRG00000045541"	"USP9X"	"A0A2I3RAB4; A0A2J8JDU7; A0A2R9BVD0; A0A6D2WW26"	""	""	"0"	"0"	"27.5"	"15.4"	"26.1"	"31.6"	"49.2"	"33.1"	"97.1"	"98.2"	"56.2"	"90.9"	"115.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3C4"	"EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1"	"4"	"1"	"2"	"1"	"175"	"19.6"	"6.79"	"309.11"	"2.17"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf08617"	"51002"	"ENSG00000144034"	"TPRKB"	"D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4"	""	"tRNA modification in the nucleus and cytosol"	"1"	"0"	"29.4"	"18.3"	"30.0"	"36.2"	"48.0"	"39.6"	"184.1"	"197.2"	"127.1"	"161.6"	"203.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12788"	"Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2"	"2"	"1"	"2"	"1"	"808"	"89.0"	"6.90"	"292.53"	"2.17"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00400, Pf08625"	"10607"	"ENSG00000183751"	"TBL3"	"hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60244"	"Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2"	"0"	"1"	"1"	"1"	"1454"	"160.5"	"8.73"	""	"2.17"	""	"1"	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf08638"	"9282"	"ENSG00000180182"	"MED14"	"hsa:9282; O60244; Q4KMR7; Q9UNB3"	"Vitamin D in inflammatory diseases"	"PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway"	"4"	"0"	"15.6"	"10.7"	"10.9"	"17.2"	"24.2"	"21.9"	"49.4"	"64.7"	"29.4"	"34.0"	"39.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UPT8"	"Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3"	"2"	"1"	"1"	"1"	"1303"	"140.2"	"6.27"	""	"2.16"	""	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00642, Pf14608, Pf18044"	"23211"	"ENSG00000130749"	"ZC3H4"	"hsa:23211; Q9UPT8; Q9Y420"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14493"	"Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1"	"3"	"1"	"2"	"1"	"270"	"31.3"	"7.47"	"264.19"	"2.16"	"1"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf15247"	"7884"	"ENSG00000163950"	"SLBP"	"B3KRJ5; hsa:7884; Q14493"	"8p23.1 copy number variation syndrome; 4p16.3 copy number variation"	"RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA"	"5"	"0"	"41.1"	"30.6"	"44.2"	"52.4"	"69.4"	"71.2"	"132.6"	"133.7"	"105.8"	"121.8"	"131.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P68402"	"Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1"	"4"	"1"	"2"	"1"	"229"	"25.6"	"5.92"	"253.20"	"2.16"	"1"	"1"	"other metabolic processes;developmental processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component"	"other molecular function"	"Pf13472"	"5049"	"ENSG00000168092"	"PAFAH1B2"	"A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6"	"PAFAH1B1 copy number variation"	"COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation"	"3"	"0"	"21.0"	"15.1"	"21.1"	"23.1"	"35.7"	"33.4"	"53.5"	"48.7"	"32.2"	"53.5"	"66.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A0A0B4J2F2"	"Probable serine/threonine-protein kinase SIK1B OS=Homo sapiens OX=9606 GN=SIK1B PE=1 SV=1"	"1"	"1"	"1"	"1"	"783"	"84.9"	"7.20"	""	"2.16"	""	"1"	"protein metabolism;other metabolic processes;signal transduction"	"nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"102724428"	""	"SIK1B"	"A0A0B4J2F2; hsa:102724428"	""	""	"0"	"0"	"85.3"	"55.0"	"88.5"	"115.9"	"144.1"	"122.1"	"529.1"	"480.2"	"305.2"	"372.8"	"427.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78332"	"RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5"	"1"	"1"	"1"	"1"	"1123"	"128.6"	"6.32"	""	"2.16"	""	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf01585, Pf17780"	"10180"	"ENSG00000004534"	"RBM6"	"B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3"	""	""	"0"	"0"	"19.0"	"12.4"	"15.1"	"27.3"	"31.0"	"24.2"	"78.0"	"72.2"	"59.6"	"58.1"	"71.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z460"	"CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1"	"1"	"1"	"2"	"1"	"1538"	"169.3"	"9.03"	"250.91"	"2.15"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;other cell component"	"cytoskeletal activity;other molecular function"	"Pf02985, Pf12348"	"23332"	"ENSG00000074054"	"CLASP1"	"A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5"	"Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Role of ABL in ROBO-SLIT signaling"	"17"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13601"	"KRR1 small subunit processome component homolog OS=Homo sapiens OX=9606 GN=KRR1 PE=1 SV=4"	"5"	"2"	"3"	"2"	"381"	"43.6"	"9.77"	"814.66"	"2.15"	"2"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	""	"Pf17903"	"11103"	"ENSG00000111615"	"KRR1"	"A0FIK6; A0JLP0; B2R989; E7EUQ0; hsa:11103; Q13601; Q8NEA8; Q8TC37; Q96AT5"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"98.0"	"49.6"	"73.8"	"93.5"	"124.1"	"110.0"	"472.9"	"466.5"	"415.2"	"538.0"	"775.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q01664"	"Transcription factor AP-4 OS=Homo sapiens OX=9606 GN=TFAP4 PE=1 SV=2"	"4"	"1"	"2"	"1"	"338"	"38.7"	"5.87"	"267.51"	"2.15"	"1"	"1"	"cell organization and biogenesis;stress response;signal transduction;other biological processes"	"mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00010"	"7023"	"ENSG00000090447"	"TFAP4"	"hsa:7023; O60409; Q01664"	"DYRK1A involvement regarding cell proliferation in brain development"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y6E0"	"Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1"	"2"	"1"	"3"	"1"	"443"	"49.3"	"5.69"	"539.99"	"2.15"	"1"	"1"	"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"8428"	"ENSG00000102572"	"STK24"	"hsa:8428; O14840; Q5JV92; Q9Y6E0"	""	"Apoptotic cleavage of cellular proteins"	"2"	"0"	"59.3"	"44.4"	"74.3"	"104.2"	"118.9"	"99.2"	"493.6"	"477.2"	"325.2"	"383.5"	"411.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q4VC05"	"B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1"	"9"	"2"	"3"	"2"	"210"	"22.8"	"5.14"	"603.99"	"2.15"	"2"	"1"	"cell organization and biogenesis;other biological processes"	"nucleus;other cell component"	""	"Pf04714"	"605"	"ENSG00000110987; ENSG00000282873"	"BCL7A"	"B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05"	""	""	"0"	"0"	"67.1"	"44.9"	"65.7"	"112.3"	"131.0"	"121.1"	"262.5"	"288.4"	"168.8"	"210.4"	"302.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14571"	"Inositol 1,4,5-trisphosphate receptor type 2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2"	"0"	"2"	"3"	"1"	"2701"	"307.9"	"6.43"	"534.78"	"2.15"	"2"	"1"	"stress response;transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"transporter activity;other molecular function"	"Pf00520, Pf01365, Pf02815, Pf08454, Pf08709"	"3709"	"ENSG00000123104"	"ITPR2"	"hsa:3709; O94773; Q14571"	"Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells"	"Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis"	"21"	"0"	"206.1"	"104.5"	"132.1"	"179.0"	"216.3"	"179.6"	"706.6"	"700.0"	"457.2"	"585.4"	"779.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BZG8"	"2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"443"	"48.8"	"8.18"	"250.12"	"2.15"	"1"	"1"	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"27.2"	"19.1"	"26.9"	"34.6"	"44.4"	"46.0"	"75.6"	"84.7"	"48.7"	"66.7"	"89.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P31323"	"cAMP-dependent protein kinase type II-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2B PE=1 SV=3"	"1"	"1"	"2"	"1"	"418"	"46.3"	"4.92"	"251.48"	"2.15"	"1"	"1"	"other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00027, Pf02197"	"5577"	"ENSG00000005249; ENSG00000284096"	"PRKAR2B"	"A4D0R9; hsa:5577; P31323"	"Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways"	"FCGR3A-mediated IL10 synthesis; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase"	"26"	"0"	"48.2"	"24.6"	"29.2"	"53.5"	"60.7"	"52.8"	"86.1"	"79.2"	"51.0"	"89.1"	"115.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H6S0"	"3'-5' RNA helicase YTHDC2 OS=Homo sapiens OX=9606 GN=YTHDC2 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1430"	"160.1"	"8.40"	"295.57"	"2.14"	"1"	"1"	"cell cycle OR cell proliferation;other biological processes"	"ER/Golgi;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf01424, Pf04146, Pf04408, Pf07717"	"64848"	"ENSG00000047188"	"YTHDC2"	"B2RP66; hsa:64848; Q9H6S0"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96PY5"	"Formin-like protein 2 OS=Homo sapiens OX=9606 GN=FMNL2 PE=1 SV=3"	"2"	"2"	"3"	"2"	"1086"	"123.2"	"7.40"	"548.75"	"2.14"	"2"	"1"	"cell organization and biogenesis;other biological processes"	"cytosol"	"cytoskeletal activity;other molecular function"	"Pf02181, Pf06367, Pf06371"	"114793"	"ENSG00000157827"	"FMNL2"	"B2RZH5; hsa:114793; Q14CC9; Q4ZG52; Q8N3E0; Q96PY5"	"Epithelial to mesenchymal transition in colorectal cancer"	"RHOC GTPase cycle; CDC42 GTPase cycle; RHO GTPases Activate Formins"	"4"	"0"	"7.0"	"4.8"	"6.8"	"6.2"	"7.8"	"8.5"	"39.8"	"29.6"	"20.5"	"25.5"	"34.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q4G0F5"	"Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2"	"2"	"1"	"1"	"1"	"336"	"39.1"	"7.36"	""	"2.14"	""	"1"	"stress response;transport;other biological processes"	"other membranes;cytosol;other cytoplasmic organelle;other cell component"	""	"Pf03643"	"112936"	"ENSG00000151502"	"VPS26B"	"hsa:112936; Q4G0F5; Q96A55"	""	""	"0"	"0"	"125.6"	"100.0"	"109.7"	"141.0"	"195.1"	"141.0"	"423.2"	"361.1"	"229.6"	"280.0"	"337.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y490"	"Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3"	"0"	"1"	"2"	"1"	"2541"	"269.6"	"6.07"	"277.40"	"2.14"	"1"	"1"	"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component"	"signal transduction activity or receptor binding;cytoskeletal activity;other molecular function"	"Pf00373, Pf01608, Pf08913, Pf09141, Pf16511"	"7094"	"ENSG00000137076"	"TLN1"	"A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490"	"Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling"	"Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins"	"18"	"0"	"18.6"	"18.7"	"31.5"	"35.3"	"37.7"	"29.8"	"254.4"	"250.9"	"204.5"	"341.0"	"708.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12767"	"Transmembrane protein 94 OS=Homo sapiens OX=9606 GN=TMEM94 PE=1 SV=1"	"0"	"1"	"1"	"1"	"1356"	"151.1"	"6.44"	""	"2.14"	""	"1"	""	"other membranes"	""	""	"9772"	"ENSG00000177728"	"TMEM94"	"C9JL75; hsa:9772; O75536; Q12767; Q86XF1"	""	""	"0"	"0"	"7.4"	"2.6"	"7.6"	"7.1"	"5.7"	"9.0"	"36.9"	"148.2"	"175.9"	"253.8"	"289.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q02040"	"A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2"	"1"	"1"	"2"	"1"	"695"	"80.7"	"9.73"	"378.89"	"2.14"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes"	"cytosol;nucleus"	"other molecular function"	""	"8227"	"ENSG00000197976"	"AKAP17A"	"hsa:8227; Q02040; Q02832; Q2TB98; Q5JQ74; Q5JQ76; Q8N6U9"	""	""	"0"	"0"	"28.2"	"18.8"	"26.6"	"29.7"	"42.6"	"37.4"	"96.9"	"79.7"	"53.4"	"88.0"	"100.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96SU4"	"Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2"	"3"	"2"	"2"	"2"	"736"	"83.1"	"6.18"	"396.67"	"2.14"	"1"	"1"	"other metabolic processes;transport"	"other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component"	"transporter activity;other molecular function"	"Pf00169, Pf01237"	"114883"	"ENSG00000117859"	"OSBPL9"	"B1AKJ8; B3KPQ4; D3DQ31; hsa:114883; Q5TFC0; Q6IA67; Q86YQ3; Q8NB17; Q8TAS8; Q96SK4; Q96SU4; Q9H9X2"	""	"Synthesis of bile acids and bile salts"	"1"	"0"	"47.5"	"26.1"	"40.3"	"68.5"	"82.4"	"65.8"	"126.1"	"108.4"	"85.7"	"104.6"	"160.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P2I0"	"Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2"	"1"	"1"	"2"	"1"	"782"	"88.4"	"5.11"	"258.66"	"2.13"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf07521, Pf10996, Pf13299, Pf16661"	"53981"	"ENSG00000165934"	"CPSF2"	"B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0"	"mRNA processing"	"mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript"	"6"	"0"	"62.7"	"44.2"	"51.9"	"90.4"	"105.2"	"85.8"	"182.1"	"176.4"	"90.1"	"135.7"	"131.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UJU3"	"Zinc finger protein 112 OS=Homo sapiens OX=9606 GN=ZNF112 PE=1 SV=2"	"1"	"1"	"1"	"1"	"913"	"105.8"	"8.27"	""	"2.13"	""	"1"	"other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00096, Pf01352"	"7771"	"ENSG00000062370"	"ZNF112"	"A4FU53; hsa:7771; Q9HCA7; Q9UJU3"	""	"Generic Transcription Pathway"	"1"	"0"	"82.7"	"57.0"	"85.3"	"88.4"	"113.2"	"115.5"	"308.7"	"280.2"	"167.5"	"226.8"	"299.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRG9"	"Aladin OS=Homo sapiens OX=9606 GN=AAAS PE=1 SV=1"	"2"	"1"	"1"	"1"	"546"	"59.5"	"7.50"	""	"2.13"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes"	"other membranes;cytosol;cytoskeleton;nucleus"	""	"Pf00400"	"8086"	"ENSG00000094914"	"AAAS"	"hsa:8086; Q5JB47; Q9NRG9; Q9NWI6; Q9UG19"	""	"HCMV Early Events; RHOA GTPase cycle; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Vpr-mediated nuclear import of PICs; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; tRNA processing in the nucleus; SUMOylation of DNA damage response and repair proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"	"29"	"0"	"21.4"	"12.8"	"16.1"	"19.6"	"26.6"	"18.7"	"50.4"	"50.4"	"21.0"	"44.3"	"47.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95298"	"NADH dehydrogenase [ubiquinone] 1 subunit C2 OS=Homo sapiens OX=9606 GN=NDUFC2 PE=1 SV=1"	"6"	"1"	"1"	"1"	"119"	"14.2"	"8.98"	""	"2.13"	""	"1"	"cell organization and biogenesis;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component"	"transporter activity"	"Pf06374"	"4718"	"ENSG00000151366"	"NDUFC2"	"E9PNU8; E9PRB2; hsa:4718; O95298; Q549M5; Q6FIH8; Q9UBJ9"	"Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation"	"Neutrophil degranulation; Complex I biogenesis"	"6"	"0"	"53.6"	"40.6"	"52.8"	"67.3"	"92.4"	"84.8"	"167.1"	"150.8"	"87.0"	"141.6"	"142.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IZS8"	"Voltage-dependent calcium channel subunit alpha-2/delta-3 OS=Homo sapiens OX=9606 GN=CACNA2D3 PE=1 SV=1"	"1"	"1"	"1"	"1"	"1091"	"122.9"	"5.78"	""	"2.13"	""	"1"	"transport;other biological processes"	"plasma membrane;other membranes"	"transporter activity;other molecular function"	"Pf08399, Pf08473, Pf13768"	"55799"	"ENSG00000157445"	"CACNA2D3"	"B2RPL6; hsa:55799; Q8IZS8; Q9NY16; Q9NY18"	"Arrhythmogenic right ventricular cardiomyopathy; MAPK signaling pathway"	"Presynaptic depolarization and calcium channel opening"	"3"	"0"	"27.3"	"22.5"	"28.0"	"36.7"	"42.2"	"41.3"	"101.3"	"94.8"	"50.1"	"75.3"	"100.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UIG0"	"Tyrosine-protein kinase BAZ1B OS=Homo sapiens OX=9606 GN=BAZ1B PE=1 SV=2"	"2"	"2"	"2"	"2"	"1483"	"170.8"	"8.48"	"446.55"	"2.13"	"1"	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00439, Pf00628, Pf10537, Pf15612, Pf15613"	"9031"	"ENSG00000009954"	"BAZ1B"	"B9EGK3; D3DXE9; hsa:9031; O95039; O95247; O95277; Q6P1K4; Q86UJ6; Q9UIG0"	"IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome"	"B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"	"5"	"0"	"12.6"	"10.2"	"12.8"	"16.8"	"21.4"	"19.0"	"71.1"	"63.9"	"34.9"	"53.7"	"66.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P39060"	"Collagen alpha-1(XVIII) chain OS=Homo sapiens OX=9606 GN=COL18A1 PE=1 SV=5"	"1"	"1"	"1"	"1"	"1754"	"178.1"	"6.01"	""	"2.13"	""	"1"	"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes"	"extracellular matrix;ER/Golgi;other cell component"	"extracellular structural activity;other molecular function"	"Pf01391, Pf01392, Pf06121, Pf06482, Pf20010"	"80781"	"ENSG00000182871"	"COL18A1"	"A8MVI4; hsa:80781; P39060; Q58EX6; Q6RZ39; Q6RZ40; Q6RZ41; Q8N4S4; Q8WXI5; Q96T70; Q9UK38; Q9Y6Q7; Q9Y6Q8"	""	"Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Laminin interactions; Activation of Matrix Metalloproteinases"	"7"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4X5"	"E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"557"	"64.1"	"5.08"	"240.13"	"2.13"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf01485, Pf19422"	"25820"	"ENSG00000166233"	"ARIH1"	"B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5"	""	"ISG15 antiviral mechanism"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H5Y7"	"SLIT and NTRK-like protein 6 OS=Homo sapiens OX=9606 GN=SLITRK6 PE=2 SV=3"	"2"	"1"	"1"	"1"	"841"	"95.0"	"6.52"	""	"2.13"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;other cell component"	""	"Pf13855"	"84189"	"ENSG00000184564"	"SLITRK6"	"A8K9S8; hsa:84189; Q495Q0; Q6AW93; Q9H5Y7; Q9HAA8; Q9NT60"	""	"Receptor-type tyrosine-protein phosphatases"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q93096"	"Protein tyrosine phosphatase type IVA 1 OS=Homo sapiens OX=9606 GN=PTP4A1 PE=1 SV=2"	"7"	"1"	"2"	"1"	"173"	"19.8"	"8.97"	"261.78"	"2.13"	"1"	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes"	"plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00782"	"7803"	"ENSG00000112245"	"PTP4A1"	"B2R6C8; hsa:7803; O00648; Q49A54; Q93096"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q06203"	"Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1"	"2"	"1"	"1"	"1"	"517"	"57.4"	"6.76"	""	"2.12"	""	"1"	"other metabolic processes"	"cytosol"	"other molecular function"	"Pf00156, Pf13522"	"5471"	"ENSG00000128059"	"PPAT"	"hsa:5471; Q06203"	"Fluoropyrimidine activity; Metabolic reprogramming in colon cancer"	"Purine ribonucleoside monophosphate biosynthesis"	"3"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78556"	"C-C motif chemokine 20 OS=Homo sapiens OX=9606 GN=CCL20 PE=1 SV=1"	"14"	"1"	"1"	"1"	"96"	"10.8"	"8.94"	""	"2.12"	""	"1"	"cell-cell signaling;stress response;signal transduction;other biological processes"	"non-structural extracellular"	"signal transduction activity or receptor binding"	"Pf00048"	"6364"	"ENSG00000115009"	"CCL20"	"hsa:6364; P78556; Q53S51; Q99664"	"Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Chemokine signaling pathway; IL-18 signaling pathway; Overview of proinflammatory and profibrotic mediators; Immune infiltration in pancreatic cancer; IL-26 signaling pathways"	"G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling"	"11"	"0"	"148.9"	"37.4"	"108.4"	"209.8"	"262.7"	"157.8"	"569.8"	"572.7"	"108.7"	"223.8"	"381.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P79522"	"Proline-rich protein 3 OS=Homo sapiens OX=9606 GN=PRR3 PE=1 SV=2"	"3"	"1"	"2"	"1"	"188"	"20.6"	"9.83"	"251.44"	"2.12"	"1"	"1"	""	""	"other molecular function"	"Pf00642"	"80742"	"ENSG00000204576; ENSG00000206491; ENSG00000223766; ENSG00000223887; ENSG00000228186; ENSG00000229202; ENSG00000233564"	"PRR3"	"A1A4H4; hsa:80742; P79522; Q5RJB5; Q5STN6"	""	""	"0"	"0"	"120.3"	"69.7"	"115.1"	"145.5"	"176.4"	"157.1"	"374.9"	"341.7"	"225.5"	"334.1"	"473.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P26640"	"Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4"	"2"	"2"	"3"	"2"	"1264"	"140.4"	"7.59"	"852.03"	"2.12"	"2"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"cytosol"	"other molecular function"	"Pf00043, Pf00133, Pf08264"	"7407"	"ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116"	"VARS1"	"B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2"	"Amino acid metabolism"	"Cytosolic tRNA aminoacylation"	"2"	"0"	"37.0"	"23.6"	"38.9"	"60.9"	"76.2"	"68.8"	"116.2"	"105.7"	"83.4"	"89.7"	"129.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A0A087WXM9"	"Meiosis-specific kinetochore protein OS=Homo sapiens OX=9606 GN=MEIKIN PE=2 SV=2"	"3"	"1"	"1"	"1"	"373"	"40.8"	"8.43"	""	"2.12"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis"	"other cell component"	""	""	"728637"	"ENSG00000239642"	"MEIKIN"	"A0A087WXM9; A0A0A8IBZ9; hsa:728637"	""	""	"0"	"0"	"228.5"	"68.7"	"138.5"	"173.4"	"224.2"	"218.7"	"257.4"	"313.0"	"115.0"	"211.0"	"391.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75563"	"Src kinase-associated phosphoprotein 2 OS=Homo sapiens OX=9606 GN=SKAP2 PE=1 SV=1"	"2"	"1"	"1"	"1"	"359"	"41.2"	"4.69"	""	"2.12"	""	"1"	"signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	""	"Pf00018, Pf00169"	"8935"	"ENSG00000005020"	"SKAP2"	"A4D173; hsa:8935; O75563; Q53GP6; Q75MK6; Q75MZ4; Q9UBZ3; Q9UED8"	""	"Signal regulatory protein family interactions"	"1"	"0"	"56.6"	"41.7"	"63.5"	"92.5"	"111.3"	"91.9"	"297.7"	"266.8"	"215.1"	"275.0"	"346.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NQP4"	"Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1"	"9"	"1"	"2"	"1"	"134"	"15.3"	"4.53"	"379.33"	"2.12"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf01920"	"5203"	"ENSG00000101132"	"PFDN4"	"hsa:5203; Q5TD11; Q92779; Q9NQP4"	"Cellular proteostasis"	"Prefoldin mediated transfer of substrate  to CCT/TriC"	"2"	"0"	"15.2"	"20.4"	"13.3"	"19.9"	"25.3"	"24.5"	"57.9"	"46.4"	"50.8"	"43.5"	"47.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBF8"	"Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1"	"1"	"1"	"2"	"1"	"816"	"91.3"	"6.25"	"255.19"	"2.12"	"1"	"1"	"cell organization and biogenesis;other metabolic processes;transport;signal transduction"	"other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component"	"kinase activity;other molecular function"	"Pf00454"	"5298"	"ENSG00000143393"	"PI4KB"	"B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8"	""	"Synthesis of PIPs at the Golgi membrane"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43488"	"Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3"	"2"	"1"	"1"	"1"	"359"	"39.6"	"7.17"	""	"2.12"	""	"1"	"other metabolic processes"	"cytosol;mitochondrion;ER/Golgi;other cell component"	"other molecular function"	"Pf00248"	"8574"	"ENSG00000053371"	"AKR7A2"	"hsa:8574; O43488; O75749; Q5TG63"	"Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II"	"Aflatoxin activation and detoxification"	"3"	"0"	"115.3"	"63.6"	"104.8"	"140.0"	"167.2"	"188.3"	"258.2"	"236.8"	"176.0"	"210.5"	"365.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UKL3"	"CASP8-associated protein 2 OS=Homo sapiens OX=9606 GN=CASP8AP2 PE=1 SV=1"	"1"	"1"	"1"	"1"	"1982"	"222.5"	"6.58"	""	"2.11"	""	"1"	"cell cycle OR cell proliferation;signal transduction;other biological processes"	"mitochondrion;nucleus;other cell component"	"signal transduction activity or receptor binding;enzyme regulator activity;other molecular function"	""	"9994"	""	"CASP8AP2"	"A2RUB7; E1P553; hsa:9994; Q6PH76; Q7LCQ7; Q86YD9; Q9NUQ4; Q9NZV9; Q9P2N1; Q9UKL3; Q9Y563"	""	"SUMOylation of transcription cofactors"	"1"	"0"	"64.0"	"37.7"	"50.9"	"62.3"	"90.2"	"79.4"	"167.6"	"173.2"	"87.5"	"114.6"	"140.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86VF2"	"Immunoglobulin-like and fibronectin type III domain-containing protein 1 OS=Homo sapiens OX=9606 GN=IGFN1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1251"	"137.7"	"7.56"	""	"2.11"	""	"1"	""	"cytoskeleton;nucleus"	""	"Pf00041, Pf07679, Pf18362"	"91156"	"ENSG00000163395"	"IGFN1"	"F8WAI1; hsa:91156; Q86VF2; Q9NT72"	""	""	"0"	"0"	"216.6"	"146.6"	"264.4"	"277.6"	"314.7"	"324.3"	"667.9"	"600.9"	"363.8"	"402.6"	"549.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P14735"	"Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4"	"1"	"1"	"1"	"1"	"1019"	"117.9"	"6.61"	""	"2.11"	""	"1"	"protein metabolism;other metabolic processes;signal transduction;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00675, Pf05193, Pf16187"	"3416"	"ENSG00000119912"	"IDE"	"B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2"	"Alzheimer's disease and miRNA effects; Alzheimer's disease"	"Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling"	"5"	"0"	"23.5"	"16.8"	"28.9"	"32.8"	"42.2"	"38.3"	"54.4"	"45.6"	"30.7"	"47.6"	"80.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99661"	"Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2"	"1"	"1"	"1"	"1"	"725"	"81.3"	"7.83"	""	"2.11"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf00225"	"11004"	"ENSG00000142945"	"KIF2C"	"B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8"	"Microtubule cytoskeleton regulation"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; MHC class II antigen presentation; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins"	"10"	"0"	"5.8"	"3.7"	"4.3"	"9.4"	"14.1"	"12.6"	"28.2"	"20.5"	"15.4"	"19.5"	"16.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q07065"	"Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2"	"2"	"1"	"1"	"1"	"602"	"66.0"	"5.92"	""	"2.11"	""	"1"	""	"plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component"	""	""	"10970"	"ENSG00000136026"	"CKAP4"	"hsa:10970; Q07065; Q504S5; Q53ES6"	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; RND2 GTPase cycle; RND3 GTPase cycle; Surfactant metabolism"	"6"	"0"	"8.2"	"3.3"	"6.9"	"14.1"	"14.1"	"14.0"	"35.2"	"39.2"	"14.7"	"22.0"	"33.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TDP1"	"Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1"	"4"	"1"	"1"	"1"	"164"	"17.8"	"5.03"	""	"2.11"	""	"1"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response"	"nucleus;other cell component"	""	"Pf08615"	"84153"	"ENSG00000172922"	"RNASEH2C"	"hsa:84153; Q8TDP1; Q9H7F5"	""	""	"0"	"0"	"22.8"	"26.0"	"38.4"	"38.2"	"64.4"	"55.4"	"129.7"	"138.7"	"84.5"	"132.6"	"122.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14517"	"Protocadherin Fat 1 OS=Homo sapiens OX=9606 GN=FAT1 PE=1 SV=2"	"0"	"1"	"1"	"1"	"4588"	"506.0"	"5.00"	""	"2.10"	""	"1"	"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;nucleus;other cell component"	"other molecular function"	"Pf00008, Pf00028, Pf02210"	"2195"	"ENSG00000083857"	"FAT1"	"hsa:2195; Q14517"	"Primary focal segmental glomerulosclerosis (FSGS); Head and neck squamous cell carcinoma"	""	"2"	"0"	"31.8"	"22.5"	"38.5"	"44.3"	"44.0"	"34.9"	"173.4"	"160.2"	"89.1"	"124.2"	"158.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13356"	"RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1"	"2"	"1"	"1"	"1"	"520"	"58.8"	"8.78"	""	"2.10"	""	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"plasma membrane;other membranes;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00160"	"23759"	"ENSG00000100023"	"PPIL2"	"hsa:23759; Q13356; Q13357; Q8TAH2; Q9BWR8"	""	"mRNA Splicing - Major Pathway; Basigin interactions"	"2"	"0"	"5.0"	"3.7"	"3.4"	"3.3"	"6.0"	"5.4"	"23.6"	"21.3"	"24.3"	"17.6"	"28.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P15927"	"Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1"	"2"	"1"	"1"	"1"	"270"	"29.2"	"6.15"	""	"2.10"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf08784"	"6118"	"ENSG00000117748"	"RPA2"	"hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5"	"miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response"	"Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"	"38"	"0"	"168.5"	"128.2"	"199.5"	"254.8"	"308.3"	"271.0"	"474.0"	"464.3"	"302.0"	"363.9"	"569.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P45880"	"Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2"	"4"	"1"	"1"	"1"	"294"	"31.5"	"7.56"	""	"2.10"	""	"1"	"cell organization and biogenesis;transport;signal transduction;other biological processes"	"other membranes;cytoskeleton;mitochondrion;other cell component"	"transporter activity;other molecular function"	"Pf01459"	"7417"	"ENSG00000165637"	"VDAC2"	"hsa:7417; P45880; Q5VWK1; Q5VWK3; Q6IB40; Q7L3J5; Q9BWK8; Q9Y5I6"	"Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease"	"Ub-specific processing proteases; Mitochondrial calcium ion transport"	"5"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75312"	"Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"459"	"50.9"	"4.73"	"245.52"	"2.10"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf03367"	"8882"	"ENSG00000109917"	"ZPR1"	"hsa:8882; O75312; Q2TAA0"	""	""	"0"	"0"	"8.9"	"4.4"	"8.9"	"13.0"	"14.4"	"14.0"	"20.3"	"33.0"	"13.0"	"19.9"	"27.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BPZ3"	"Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1"	"6"	"1"	"2"	"1"	"127"	"15.0"	"4.12"	"247.56"	"2.09"	"1"	"1"	"protein metabolism;other metabolic processes;other biological processes"	"other cell component"	"nucleic acid binding activity;other molecular function"	"Pf07145"	"51247"	"ENSG00000120727"	"PAIP2"	"B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8"	""	""	"0"	"0"	"60.5"	"41.7"	"63.8"	"74.4"	"100.2"	"85.9"	"348.8"	"324.3"	"237.5"	"278.4"	"292.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O43818"	"U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1"	"1"	"1"	"2"	"1"	"475"	"51.8"	"7.85"	"234.02"	"2.08"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00400"	"9136"	"ENSG00000114767"	"RRP9"	"B2R996; hsa:9136; O43818; Q8IZ30"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	"87.3"	"67.6"	"77.3"	"74.3"	"94.2"	"90.3"	"246.2"	"253.8"	"216.4"	"393.0"	"290.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P08243"	"Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4"	"2"	"1"	"2"	"1"	"561"	"64.3"	"6.86"	"299.23"	"2.08"	"1"	"1"	"other metabolic processes;stress response;other biological processes"	"cytosol"	"other molecular function"	"Pf00733, Pf13537"	"440"	"ENSG00000070669"	"ASNS"	"A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0"	"Photodynamic therapy-induced unfolded protein response; Amino acid metabolism"	"Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum  stress; Response of EIF2AK4 (GCN2) to amino acid deficiency"	"6"	"0"	"67.8"	"67.8"	"74.8"	"80.8"	"113.6"	"97.0"	"200.0"	"173.7"	"120.1"	"172.4"	"210.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14C86"	"GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1478"	"164.9"	"5.22"	""	"2.08"	""	"1"	"transport;other biological processes"	"plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component"	"enzyme regulator activity;other molecular function"	"Pf00616, Pf02204, Pf18151"	"26130"	"ENSG00000165219"	"GAPVD1"	"A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0"	""	"RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23193"	"Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2"	"11"	"3"	"4"	"3"	"301"	"33.9"	"8.38"	"973.13"	"2.08"	"3"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"nucleic acid binding activity;other molecular function"	"Pf01096, Pf07500, Pf08711"	"6917"	"ENSG00000187735"	"TCEA1"	"A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87"	""	"Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER"	"15"	"0"	"51.6"	"25.5"	"53.7"	"71.8"	"97.3"	"92.4"	"280.0"	"309.2"	"165.7"	"247.3"	"391.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P13489"	"Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2"	"2"	"1"	"2"	"1"	"461"	"49.9"	"4.82"	"372.18"	"2.08"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component"	"enzyme regulator activity"	"Pf13516, Pf18779"	"6050"	"ENSG00000023191; ENSG00000276230"	"RNH1"	"hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6"	""	""	"0"	"0"	"13.2"	"12.1"	"17.5"	"25.4"	"30.9"	"28.0"	"48.7"	"45.8"	"30.4"	"40.1"	"47.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95644"	"Nuclear factor of activated T-cells, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=NFATC1 PE=1 SV=3"	"1"	"1"	"2"	"1"	"943"	"101.2"	"6.99"	"254.66"	"2.08"	"1"	"1"	"developmental processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00554, Pf16179"	"4772"	"ENSG00000131196"	"NFATC1"	"B5B2M4; B5B2M5; B5B2M6; B5B2M7; B5B2M8; B5B2M9; B5B2N1; hsa:4772; O95644; Q12865; Q15793; Q2M1S3"	"Heart development; RANKL/RANK signaling pathway; Ectoderm differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Wnt signaling; Vitamin D in inflammatory diseases; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; Th17 cell differentiation pathway; DYRK1A involvement regarding cell proliferation in brain development; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; IL-26 signaling pathways; T-cell receptor signaling pathway"	"FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT"	"20"	"0"	"67.3"	"47.3"	"68.6"	"97.9"	"116.3"	"103.6"	"213.4"	"225.5"	"109.0"	"158.9"	"234.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z2Y5"	"Nik-related protein kinase OS=Homo sapiens OX=9606 GN=NRK PE=1 SV=2"	"1"	"1"	"1"	"1"	"1582"	"178.4"	"6.33"	""	"2.07"	""	"1"	"protein metabolism;other metabolic processes"	""	"kinase activity;other molecular function"	"Pf00069, Pf00780"	"203447"	"ENSG00000123572"	"NRK"	"hsa:203447; Q32ND6; Q5H9K2; Q6ZMP2; Q7Z2Y5"	"NAD+ metabolism"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N4Q1"	"Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1"	"4"	"1"	"1"	"1"	"142"	"16.0"	"4.31"	""	"2.07"	""	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport"	"mitochondrion"	"other molecular function"	"Pf06747"	"131474"	"ENSG00000163528"	"CHCHD4"	"A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6"	""	"Mitochondrial protein import"	"1"	"0"	"113.6"	"61.1"	"95.8"	"120.8"	"147.3"	"119.0"	"270.5"	"281.1"	"160.2"	"164.4"	"271.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TCX5"	"Rhophilin-1 OS=Homo sapiens OX=9606 GN=RHPN1 PE=1 SV=2"	"2"	"1"	"1"	"1"	"670"	"73.5"	"7.53"	""	"2.07"	""	"1"	"protein metabolism;signal transduction;other biological processes"	"cytosol"	""	"Pf00595, Pf02163, Pf02185, Pf03097"	"114822"	"ENSG00000158106"	"RHPN1"	"hsa:114822; Q8TAV1; Q8TCX5; Q96PV9"	"Ectoderm differentiation"	"RHOA GTPase cycle; RHO GTPases Activate Rhotekin and Rhophilins"	"3"	"0"	"11.4"	"2.4"	"12.2"	"14.5"	"17.5"	"18.4"	"149.5"	"439.3"	"568.9"	"1262.5"	"2248.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75935"	"Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1"	"6"	"1"	"2"	"1"	"186"	"21.1"	"5.47"	"256.46"	"2.07"	"1"	"1"	"cell cycle OR cell proliferation;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf07426"	"11258"	"ENSG00000137100"	"DCTN3"	"A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8"	""	"MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2"	"11"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q12797"	"Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH PE=1 SV=3"	"2"	"2"	"3"	"2"	"758"	"85.8"	"5.01"	"507.16"	"2.07"	"2"	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi"	"other molecular function"	"Pf05118, Pf05279, Pf13432"	"444"	"ENSG00000198363"	"ASPH"	"A0A0A0MSK8; A6NDF4; A6NHI2; B4DIC9; B4E2K4; B7ZM95; E5RGP5; F5H667; hsa:444; Q12797; Q6NXR7; Q8TB28; Q9H291; Q9H2C4; Q9NRI0; Q9NRI1; Q9Y4J0"	""	"Stimuli-sensing channels; Ion homeostasis"	"2"	"0"	"46.3"	"23.5"	"35.0"	"39.1"	"57.5"	"44.4"	"118.8"	"125.9"	"74.5"	"119.0"	"165.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P23511"	"Nuclear transcription factor Y subunit alpha OS=Homo sapiens OX=9606 GN=NFYA PE=1 SV=2"	"2"	"1"	"2"	"1"	"347"	"36.9"	"8.94"	"376.16"	"2.07"	"1"	"1"	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02045"	"4800"	"ENSG00000001167"	"NFYA"	"hsa:4800; P23511; Q8IXU0"	"Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways"	"PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes"	"8"	"0"	"47.9"	"22.2"	"41.3"	"66.9"	"97.6"	"67.7"	"217.6"	"228.1"	"136.8"	"169.7"	"323.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P37198"	"Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3"	"3"	"1"	"1"	"1"	"522"	"53.2"	"5.31"	""	"2.07"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes"	"other membranes;cytoskeleton;nucleus;other cell component"	"other molecular function"	"Pf05064"	"23636"	"ENSG00000213024"	"NUP62"	"B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1"	"7q11.23 copy number variation syndrome"	"Regulation of HSF1-mediated heat shock response; Nuclear Pore Complex (NPC) Disassembly; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation"	"30"	"0"	"8.4"	"6.1"	"5.5"	"9.0"	"11.6"	"11.0"	"35.2"	"29.0"	"17.3"	"20.0"	"33.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95721"	"Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1"	"4"	"1"	"2"	"1"	"258"	"29.0"	"5.81"	"293.34"	"2.06"	"1"	"1"	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	""	"9342"	"ENSG00000099940"	"SNAP29"	"hsa:9342; O95721"	"Ciliary landscape; 22q11.2 copy number variation syndrome"	"Neutrophil degranulation; Intra-Golgi traffic"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IXM3"	"39S ribosomal protein L41, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1"	"5"	"1"	"1"	"1"	"137"	"15.4"	"9.57"	""	"2.06"	""	"1"	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes"	"other membranes;mitochondrion;translational apparatus;other cell component"	"other molecular function"	"Pf09809"	"64975"	"ENSG00000182154"	"MRPL41"	"hsa:64975; Q8IXM3; Q96Q49"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"16.7"	"15.1"	"26.2"	"30.6"	"39.1"	"22.9"	"62.7"	"59.1"	"35.6"	"53.5"	"48.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P51178"	"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Homo sapiens OX=9606 GN=PLCD1 PE=1 SV=2"	"2"	"1"	"1"	"1"	"756"	"85.6"	"6.70"	""	"2.06"	""	"1"	"other metabolic processes;transport;signal transduction"	"plasma membrane;other membranes;other cell component"	"other molecular function"	"Pf00168, Pf00387, Pf00388, Pf09279"	"5333"	"ENSG00000187091"	"PLCD1"	"B3KR14; hsa:5333; P51178; Q86VN8"	"Myometrial relaxation and contraction pathways; GPR40 pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Orexin receptor pathway"	"Synthesis of IP3 and IP4 in the cytosol"	"6"	"0"	"33.7"	"18.3"	"25.0"	"16.1"	"30.9"	"56.8"	"53.5"	"439.6"	"24.6"	"30.1"	"42.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15050"	"Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2"	"3"	"1"	"2"	"1"	"365"	"41.2"	"10.70"	"444.20"	"2.06"	"1"	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity"	"Pf04939"	"23212"	"ENSG00000179041"	"RRS1"	"hsa:23212; Q15050; Q9BUX8"	""	""	"0"	"0"	"19.0"	"5.5"	"11.0"	"21.3"	"19.9"	"17.6"	"58.1"	"57.6"	"21.7"	"39.1"	"48.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H5V8"	"CUB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CDCP1 PE=1 SV=3"	"2"	"1"	"1"	"1"	"836"	"92.9"	"7.96"	""	"2.06"	""	"1"	""	"non-structural extracellular;plasma membrane;other membranes"	""	""	"64866"	"ENSG00000163814"	"CDCP1"	"hsa:64866; Q49UB4; Q6NT71; Q6U9Y2; Q8WU91; Q96QU7; Q9H5V8; Q9H676; Q9H8C2"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P30046"	"D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3"	"9"	"1"	"1"	"1"	"118"	"12.7"	"7.30"	""	"2.05"	""	"1"	"other metabolic processes;other biological processes"	"non-structural extracellular;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf01187"	"1652"	"ENSG00000099977; ENSG00000275003"	"DDT"	"B7Z522; hsa:1652; O00774; O60787; P30046; Q13534"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H4X1"	"Regulator of cell cycle RGCC OS=Homo sapiens OX=9606 GN=RGCC PE=1 SV=1"	"8"	"1"	"2"	"1"	"137"	"14.6"	"4.75"	"246.64"	"2.05"	"1"	"1"	"cell cycle OR cell proliferation;stress response;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf15151"	"28984"	"ENSG00000102760"	"RGCC"	"hsa:28984; Q6NZ48; Q9H4X1; Q9UL69"	""	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q53H96"	"Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3"	"4"	"1"	"1"	"1"	"274"	"28.6"	"7.72"	""	"2.04"	""	"1"	"other metabolic processes"	"cytosol;cytoskeleton;other cell component"	"other molecular function"	"Pf03807, Pf14748"	"65263"	"ENSG00000104524; ENSG00000276657"	"PYCR3"	"B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896"	""	"Glutamate and glutamine metabolism"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9GZZ9"	"Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1"	"3"	"1"	"1"	"1"	"404"	"44.8"	"4.84"	""	"2.04"	""	"1"	"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00899"	"79876"	"ENSG00000081307"	"UBA5"	"A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9"	""	"Antigen processing: Ubiquitination & Proteasome degradation"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14690"	"Protein RRP5 homolog OS=Homo sapiens OX=9606 GN=PDCD11 PE=1 SV=3"	"1"	"1"	"1"	"1"	"1871"	"208.6"	"8.87"	""	"2.03"	""	"1"	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00575, Pf05843"	"22984"	"ENSG00000148843"	"PDCD11"	"hsa:22984; Q14690; Q2TA92; Q5W093; Q6P2J3; Q86VQ8; Q9H4P1"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IX01"	"SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2"	"1"	"1"	"2"	"1"	"1082"	"120.1"	"7.28"	"446.31"	"2.03"	"1"	"1"	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf01585, Pf01805"	"10147"	"ENSG00000064607"	"SUGP2"	"C9JI71; hsa:10147; O15071; O60369; Q5JPH7; Q8IX01; Q8WUF7"	"mRNA processing"	""	"1"	"0"	"23.1"	"11.4"	"13.8"	"22.2"	"38.2"	"29.8"	"67.1"	"50.8"	"33.6"	"56.1"	"77.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H0U3"	"Magnesium transporter protein 1 OS=Homo sapiens OX=9606 GN=MAGT1 PE=1 SV=1"	"3"	"1"	"2"	"1"	"335"	"38.0"	"9.63"	"284.04"	"2.03"	"1"	"1"	"protein metabolism;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle"	"transporter activity"	"Pf04756"	"84061"	"ENSG00000102158"	"MAGT1"	"B2RAR4; D3DTE3; hsa:84061; Q53G00; Q6P577; Q8NBN6; Q9H0U3"	""	"Neutrophil degranulation; Miscellaneous transport and binding events; Asparagine N-linked glycosylation; Maturation of spike protein"	"4"	"0"	"9.2"	"3.8"	"5.4"	"6.7"	"12.0"	"12.2"	"49.2"	"44.4"	"30.6"	"41.3"	"38.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P02671"	"Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2"	"1"	"1"	"1"	"1"	"866"	"94.9"	"6.01"	""	"2.03"	""	"1"	"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf00147, Pf08702, Pf12160"	"2243"	"ENSG00000171560"	"FGA"	"A8K3E4; D3DP14; D3DP15; hsa:2243; P02671; Q4QQH7; Q9BX62; Q9UCH2"	"Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway"	"ER-Phagosome pathway; Amyloid fiber formation; Integrin cell surface interactions; Platelet degranulation ; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins"	"29"	"0"	"104.1"	"53.2"	"108.4"	"121.8"	"163.4"	"137.5"	"640.0"	"504.2"	"273.5"	"299.6"	"296.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92905"	"COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4"	"3"	"1"	"1"	"1"	"334"	"37.6"	"6.54"	""	"2.03"	""	"1"	"protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01398, Pf18323"	"10987"	"ENSG00000121022"	"COPS5"	"hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17"	""	"Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; Neddylation; DNA Damage Recognition in GG-NER"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"Q641Q2"	"WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3"	"2"	"2"	"2"	"2"	"1341"	"147.1"	"4.81"	"317.34"	"2.03"	"1"	"1"	"transport;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf15255"	"387680"	"ENSG00000099290"	"WASHC2A"	"A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0"	""	""	"0"	"0"	"8.7"	"6.5"	"9.6"	"12.7"	"18.0"	"14.7"	"40.2"	"44.4"	"24.3"	"39.4"	"40.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49642"	"DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1"	"3"	"1"	"1"	"1"	"420"	"49.9"	"8.21"	""	"2.02"	""	"1"	"DNA metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf01896"	"5557"	"ENSG00000198056"	"PRIM1"	"hsa:5557; P49642"	"Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication"	"Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation"	"13"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P04632"	"Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1"	"9"	"1"	"1"	"1"	"268"	"28.3"	"5.20"	""	"0.00"	""	"1"	"protein metabolism;other biological processes"	"plasma membrane;other membranes;cytosol;other cell component"	"other molecular function"	""	"826"	"ENSG00000126247"	"CAPNS1"	"A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0"	"Integrin-mediated cell adhesion"	"Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"	"4"	"0"	"25.8"	"14.9"	"26.4"	"33.5"	"40.4"	"41.3"	"77.6"	"74.3"	"41.2"	"59.6"	"94.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H0B6"	"Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1"	"4"	"1"	"1"	"1"	"622"	"68.9"	"7.15"	""	"0.00"	""	"1"	"other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component"	"cytoskeletal activity"	"Pf13424"	"64837"	"ENSG00000174996"	"KLC2"	"A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20"	"Alzheimer's disease and miRNA effects; Alzheimer's disease"	"MHC class II antigen presentation; RHO GTPases activate KTN1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins"	"6"	"0"	"52.1"	"35.1"	"65.2"	"70.6"	"79.7"	"71.3"	"82.5"	"47.3"	"47.2"	"62.1"	"120.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5T7B8"	"Kinesin-like protein KIF24 OS=Homo sapiens OX=9606 GN=KIF24 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1368"	"151.8"	"7.14"	""	"0.00"	""	"1"	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00225, Pf00536"	"347240"	"ENSG00000186638"	"KIF24"	"hsa:347240; Q2TB93; Q5T7B5; Q5T7B7; Q5T7B8; Q6ZU97; Q6ZUZ2; Q86XZ0; Q9NV43"	""	"Anchoring of the basal body to the plasma membrane"	"1"	"0"	"20.1"	"18.4"	"27.0"	"24.7"	"29.3"	"33.9"	"41.0"	"38.1"	"30.4"	"32.2"	"47.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y5H8"	"Protocadherin alpha-3 OS=Homo sapiens OX=9606 GN=PCDHA3 PE=2 SV=1"	"5"	"1"	"1"	"1"	"950"	"102.4"	"5.08"	""	"0.00"	""	"1"	"cell adhesion;developmental processes"	"plasma membrane;other membranes"	"other molecular function"	"Pf00028, Pf08266, Pf15974"	"56145"	"ENSG00000255408"	"PCDHA3"	"hsa:56145; O75286; Q9Y5H8"	""	""	"0"	"0"	"30.4"	"7.8"	"18.2"	"21.3"	"29.1"	"19.9"	"41.6"	"42.1"	"21.0"	"38.6"	"42.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q08174"	"Protocadherin-1 OS=Homo sapiens OX=9606 GN=PCDH1 PE=1 SV=2"	"2"	"1"	"1"	"1"	"1060"	"114.7"	"5.03"	""	"0.00"	""	"1"	"cell adhesion;cell-cell signaling;developmental processes"	"plasma membrane;other membranes;nucleus;other cell component"	"other molecular function"	"Pf00028, Pf08266, Pf08374"	"5097"	"ENSG00000156453"	"PCDH1"	"hsa:5097; Q08174; Q8IUP2"	""	""	"0"	"0"	"18.6"	"5.6"	"15.1"	"14.7"	"21.0"	"24.9"	"100.7"	"116.0"	"39.7"	"63.1"	"84.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q0VD83"	"Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3"	"3"	"1"	"1"	"1"	"1097"	"115.6"	"4.40"	""	"0.00"	""	"1"	"other metabolic processes;transport"	"non-structural extracellular;plasma membrane;other membranes"	"other molecular function"	""	"55911"	"ENSG00000184730"	"APOBR"	"H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9"	""	"VLDL clearance"	"1"	"0"	"17.7"	"3.0"	"10.4"	"17.8"	"26.0"	"18.4"	"44.4"	"47.0"	"12.7"	"16.6"	"36.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P39059"	"Collagen alpha-1(XV) chain OS=Homo sapiens OX=9606 GN=COL15A1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1388"	"141.6"	"5.00"	""	"0.00"	""	"1"	"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;extracellular matrix;other membranes;ER/Golgi"	"extracellular structural activity"	"Pf01391, Pf06482, Pf20010"	"1306"	"ENSG00000204291"	"COL15A1"	"hsa:1306; P39059; Q5T6J4; Q9UDC5; Q9Y4W4"	""	"Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TAL5"	"Uncharacterized protein C9orf43 OS=Homo sapiens OX=9606 GN=C9orf43 PE=1 SV=1"	"5"	"1"	"1"	"1"	"461"	"52.2"	"8.87"	""	"0.00"	""	"1"	""	""	""	"Pf15504"	"257169"	"ENSG00000157653"	"C9orf43"	"hsa:257169; Q8TAL5"	""	""	"0"	"0"	"10.2"	"2.8"	"11.2"	"13.1"	"17.9"	"14.1"	"132.2"	"157.7"	"88.2"	"119.5"	"126.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P45974"	"Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2"	"5"	"3"	"3"	"3"	"858"	"95.7"	"5.03"	"1565.24"	""	"3"	""	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cytoplasmic organelle"	"other molecular function"	"Pf00443, Pf00627, Pf02148, Pf17807"	"8078"	"ENSG00000111667"	"USP5"	"D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22"	"IL-18 signaling pathway"	"Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases"	"3"	"0"	"28.2"	"26.1"	"29.1"	"50.6"	"59.4"	"59.6"	"104.4"	"113.8"	"63.7"	"99.8"	"176.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49591"	"Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3"	"5"	"3"	"3"	"3"	"514"	"58.7"	"6.43"	"1175.53"	""	"3"	""	"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00587, Pf02403"	"6301"	"ENSG00000031698"	"SARS1"	"B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3"	"VEGFA-VEGFR2 signaling"	"Selenocysteine synthesis; Cytosolic tRNA aminoacylation"	"3"	"0"	"70.9"	"76.4"	"99.5"	"123.0"	"137.3"	"130.9"	"258.2"	"242.1"	"180.7"	"261.2"	"324.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P49411"	"Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2"	"5"	"2"	"2"	"2"	"452"	"49.5"	"7.61"	"843.73"	""	"2"	""	""	""	""	""	""	""	""	""	""	""	"0"	"0"	"168.5"	"129.8"	"176.3"	"239.0"	"270.5"	"257.2"	"618.7"	"548.8"	"456.6"	"589.0"	"748.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P021"	"Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1"	"12"	"1"	"2"	"1"	"101"	"11.2"	"9.47"	"676.85"	""	"1"	""	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf10235"	"9419"	"ENSG00000119878"	"CRIPT"	"hsa:9419; Q9P021"	""	""	"0"	"0"	"17.0"	"8.8"	"17.7"	"19.3"	"22.1"	"28.6"	"89.8"	"87.3"	"76.7"	"112.2"	"171.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q99627"	"COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1"	"6"	"1"	"1"	"1"	"209"	"23.2"	"5.38"	"567.99"	""	"1"	""	"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf10075"	"10920"	"ENSG00000198612"	"COPS8"	"A8K1H6; hsa:10920; Q53QS9; Q99627"	"Ciliary landscape; 2q37 copy number variation syndrome"	"DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex"	"6"	"0"	"33.4"	"21.3"	"27.0"	"39.6"	"47.8"	"45.3"	"85.8"	"78.1"	"54.3"	"85.2"	"105.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q7Z478"	"ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2"	"2"	"2"	"2"	"2"	"1369"	"155.1"	"8.09"	"567.07"	""	"2"	""	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf04408, Pf07717"	"54505"	"ENSG00000067248"	"DHX29"	"hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"4.4"	"3.9"	"6.9"	"11.6"	"9.5"	"4.8"	"36.1"	"32.7"	"33.0"	"34.5"	"48.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IZL8"	"Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1130"	"119.6"	"4.34"	"566.81"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf08166, Pf08167"	"27043"	"ENSG00000141456"	"PELP1"	"hsa:27043; O15450; Q5EGN3; Q6NTE6; Q8IZL8; Q96FT1; Q9BU60"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression"	"2"	"0"	"4.4"	"0.0"	"3.3"	"6.0"	"10.3"	"6.4"	"24.2"	"27.0"	"12.5"	"11.8"	"15.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16543"	"Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1"	"5"	"2"	"2"	"2"	"378"	"44.4"	"5.25"	"561.37"	""	"2"	""	"protein metabolism;other metabolic processes;stress response;transport;other biological processes"	"cytosol;other cell component"	"enzyme regulator activity;other molecular function"	"Pf03234, Pf08564, Pf08565"	"11140"	"ENSG00000105401"	"CDC37"	"hsa:11140; Q16543; Q53YA2"	"TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway"	"Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants"	"27"	"0"	"58.2"	"38.2"	"70.4"	"87.8"	"135.0"	"103.4"	"205.7"	"197.1"	"127.3"	"167.3"	"217.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q71RC2"	"La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3"	"2"	"1"	"1"	"1"	"724"	"80.5"	"6.61"	"547.01"	""	"1"	""	"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes"	"cytosol;other cell component"	"nucleic acid binding activity"	"Pf05383"	"113251"	"ENSG00000161813"	"LARP4"	"A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9"	""	""	"0"	"0"	"6.5"	"7.4"	"8.4"	"15.4"	"17.2"	"16.6"	"33.0"	"40.3"	"20.1"	"16.5"	"15.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8IY81"	"pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 OS=Homo sapiens OX=9606 GN=FTSJ3 PE=1 SV=2"	"2"	"1"	"1"	"1"	"847"	"96.5"	"8.40"	"503.66"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"other molecular function"	"Pf01728, Pf07780, Pf11861"	"117246"	"ENSG00000108592"	"FTSJ3"	"B2RCA5; D3DU22; hsa:117246; Q8IY81; Q8N3A3; Q8WXX1; Q9BWM4; Q9NXT6"	""	"Major pathway of rRNA processing in the nucleolus and cytosol"	"1"	"0"	"8.5"	"4.0"	"4.5"	"6.5"	"6.8"	"4.7"	"38.9"	"31.9"	"21.7"	"27.6"	"31.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y4A5"	"Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3"	"0"	"2"	"2"	"2"	"3859"	"437.3"	"8.19"	"494.19"	""	"2"	""	"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00454, Pf02259, Pf20175, Pf20206"	"8295"	"ENSG00000196367"	"TRRAP"	"A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4"	"Rett syndrome causing genes"	"Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones"	"4"	"0"	"50.9"	"29.8"	"40.6"	"58.1"	"77.5"	"86.3"	"96.9"	"90.7"	"69.9"	"70.5"	"157.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P25490"	"Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2"	"4"	"1"	"1"	"1"	"414"	"44.7"	"6.25"	"459.48"	""	"1"	""	"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00096"	"7528"	"ENSG00000100811"	"YY1"	"hsa:7528; P25490; Q14935"	"Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma"	"Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"	"8"	"0"	"5.7"	"3.6"	"3.9"	"6.6"	"10.5"	"6.9"	"52.7"	"49.4"	"30.5"	"30.8"	"46.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3C1"	"Nucleolar protein 16 OS=Homo sapiens OX=9606 GN=NOP16 PE=1 SV=2"	"10"	"1"	"1"	"1"	"178"	"21.2"	"9.94"	"451.75"	""	"1"	""	"other biological processes"	"nucleus;other cell component"	""	"Pf09420"	"51491"	"ENSG00000048162"	"NOP16"	"B4DV13; D6RGD3; hsa:51491; Q05D05; Q6IAI6; Q6PIM0; Q8IXL5; Q9Y3C1"	"5q35 copy number variation"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H6R0"	"ATP-dependent RNA helicase DHX33 OS=Homo sapiens OX=9606 GN=DHX33 PE=1 SV=2"	"2"	"1"	"1"	"1"	"707"	"78.8"	"8.91"	"449.23"	""	"1"	""	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	"translation activity;nucleic acid binding activity;other molecular function"	"Pf00270, Pf00271, Pf04408, Pf07717"	"56919"	"ENSG00000005100"	"DHX33"	"B4DHF9; hsa:56919; Q4G149; Q5CZ73; Q9H5M9; Q9H6R0"	""	""	"0"	"0"	"4.5"	"2.4"	"7.2"	"4.0"	"6.1"	"5.6"	"19.7"	"17.5"	"17.8"	"17.6"	"15.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P63000"	"Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1"	"8"	"1"	"1"	"1"	"192"	"21.4"	"8.50"	"443.81"	""	"1"	""	"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf00071"	"5879"	"ENSG00000136238"	"RAC1"	"hsa:5879; O95501; P15154; P63000; Q3Y4D3; Q5JAA8; Q9BTB4"	"Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Target of rapamycin signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Cardiac hypertrophic response; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Robo4 and VEGF signaling pathways crosstalk; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Ciliary landscape; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Netrin-UNC5B signaling pathway; Insulin signaling; CAMKK2 pathway; Opioid receptor pathways; Regulation of actin cytoskeleton; GDNF signaling; 2q13 copy number variation syndrome; 2q21.1 copy number variation syndrome; 2q37 copy number variation syndrome; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; 13q12.12 copy number variation; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway"	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; RAC1 GTPase cycle; NRAGE signals death through JNK; DCC mediated attractive signaling; FCERI mediated MAPK activation; Neutrophil degranulation; Signaling by SCF-KIT; DAP12 signaling; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; EPH-ephrin mediated repulsion of cells; MAPK6/MAPK4 signaling; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Ephrin signaling; Factors involved in megakaryocyte development and platelet production; RHO GTPases activate CIT; PCP/CE pathway; WNT5:FZD7-mediated leishmania damping; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signal transduction by L1; RHO GTPases activate PKNs; RHO GTPases activate PAKs; DSCAM interactions; Azathioprine ADME; VEGFR2 mediated vascular permeability; Sema4D mediated inhibition of cell attachment and migration; Inactivation of CDC42 and RAC1; Activation of RAC1; CD28 dependent Vav1 pathway; Nef and signal transduction; RHO GTPases Activate NADPH Oxidases; NTRK2 activates RAC1; MET activates RAP1 and RAC1; Activation of RAC1 downstream of NMDARs; Activated NTRK2 signals through CDK5; RHO GTPases activate KTN1"	"108"	"0"	"6.7"	"5.2"	"7.4"	"10.2"	"10.9"	"9.2"	"24.4"	"24.6"	"19.4"	"27.6"	"28.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52926"	"High mobility group protein HMGI-C OS=Homo sapiens OX=9606 GN=HMGA2 PE=1 SV=1"	"8"	"1"	"1"	"1"	"109"	"11.8"	"10.62"	"442.77"	""	"1"	""	"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf02178"	"8091"	"ENSG00000149948"	"HMGA2"	"E7EP85; E7EWA2; hsa:8091; P52926; Q1M182; Q1M185; Q1M186; Q1M187; Q1M188"	"Mesodermal commitment pathway; Mesodermal commitment pathway; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway"	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"	"6"	"0"	"52.1"	"22.7"	"46.8"	"54.9"	"63.4"	"66.3"	"203.1"	"188.4"	"124.3"	"154.9"	"229.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P48634"	"Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3"	"1"	"1"	"1"	"1"	"2157"	"228.7"	"9.45"	"433.89"	""	"1"	""	"other biological processes"	"plasma membrane;other membranes;cytosol;nucleus"	""	"Pf07001"	"7916"	"ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825"	"PRRC2A"	"B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6"	""	""	"0"	"0"	"3.0"	"4.6"	"8.4"	"9.7"	"9.3"	"7.6"	"48.7"	"45.6"	"54.1"	"48.9"	"56.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BW85"	"Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1"	"5"	"1"	"1"	"1"	"323"	"37.1"	"5.92"	"432.21"	""	"1"	""	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus"	"other molecular function"	"Pf04502"	"55702"	"ENSG00000105248"	"YJU2"	"hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O60934"	"Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1"	"2"	"1"	"1"	"1"	"754"	"84.9"	"6.90"	"417.54"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00498, Pf08599, Pf16508"	"4683"	"ENSG00000104320"	"NBN"	"B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2"	"miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response"	"Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks"	"29"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3D8"	"Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1"	"9"	"1"	"1"	"1"	"172"	"20.0"	"4.58"	"416.99"	""	"1"	""	"other metabolic processes"	"cytoskeleton;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf13238"	"102157402"	"ENSG00000085231; ENSG00000279247"	"AK6"	"A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8"	""	"Interconversion of nucleotide di- and triphosphates"	"1"	"0"	"20.5"	"23.8"	"28.5"	"28.7"	"38.1"	"32.2"	"70.5"	"66.1"	"64.8"	"70.6"	"76.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8NFH5"	"Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1"	"2"	"1"	"1"	"1"	"326"	"34.8"	"9.09"	"380.82"	""	"1"	""	"cell organization and biogenesis;transport;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf05172"	"129401"	"ENSG00000163002"	"NUP35"	"B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1"	""	"Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of RNA binding proteins; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation"	"29"	"0"	"57.6"	"27.5"	"49.7"	"58.2"	"71.5"	"62.9"	"227.1"	"212.1"	"127.1"	"154.7"	"179.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92552"	"28S ribosomal protein S27, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3"	"3"	"1"	"1"	"1"	"414"	"47.6"	"6.18"	"378.26"	""	"1"	""	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes"	"other membranes;mitochondrion;translational apparatus;nucleus;other cell component"	"translation activity;nucleic acid binding activity"	"Pf10037"	"23107"	"ENSG00000113048"	"MRPS27"	"B4DRT2; hsa:23107; Q6P1S1; Q92552"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"28.7"	"16.1"	"24.9"	"37.6"	"41.0"	"34.6"	"64.6"	"62.1"	"43.7"	"44.3"	"65.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BYN8"	"28S ribosomal protein S26, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1"	"5"	"1"	"1"	"1"	"205"	"24.2"	"10.39"	"372.52"	""	"1"	""	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	""	"Pf14943"	"64949"	"ENSG00000125901"	"MRPS26"	"hsa:64949; Q96Q58; Q9BYN8"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"54.9"	"41.2"	"57.9"	"72.2"	"106.6"	"85.6"	"164.0"	"137.6"	"88.7"	"123.0"	"161.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q08426"	"Peroxisomal bifunctional enzyme OS=Homo sapiens OX=9606 GN=EHHADH PE=1 SV=3"	"2"	"1"	"1"	"1"	"723"	"79.4"	"9.14"	"364.88"	""	"1"	""	"other metabolic processes"	"cytosol;other cytoplasmic organelle"	"other molecular function"	"Pf00378, Pf00725, Pf02737"	"1962"	"ENSG00000113790"	"EHHADH"	"A8K6Y3; B4DWG3; D3DNU0; hsa:1962; Q08426; Q58EZ5"	"Constitutive androstane receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Mitochondrial fatty acid oxidation disorders"	"Peroxisomal protein import; Beta-oxidation of very long chain fatty acids"	"12"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86UE8"	"Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2"	"2"	"1"	"1"	"1"	"772"	"87.6"	"8.41"	"360.20"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"kinase activity;other molecular function"	"Pf00069"	"11011"	"ENSG00000146872"	"TLK2"	"D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7"	"miRNA regulation of DNA damage response; DNA damage response"	""	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BY32"	"Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2"	"6"	"1"	"1"	"1"	"194"	"21.4"	"5.66"	"357.94"	""	"1"	""	"cell organization and biogenesis;other metabolic processes"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf01725"	"3704"	"ENSG00000125877"	"ITPA"	"A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8"	""	"Purine catabolism; Ribavirin ADME"	"2"	"0"	"7.2"	"4.4"	"8.0"	"14.2"	"16.2"	"15.4"	"32.6"	"29.0"	"18.5"	"22.0"	"31.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P34741"	"Syndecan-2 OS=Homo sapiens OX=9606 GN=SDC2 PE=1 SV=2"	"4"	"1"	"1"	"1"	"201"	"22.1"	"4.86"	"340.83"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component"	"other molecular function"	"Pf01034"	"6383"	"ENSG00000169439"	"SDC2"	"B3KQA3; hsa:6383; P34741; Q6PIS6; Q9H6V1"	"miRNA targets in ECM and membrane receptors"	"Cell surface interactions at the vascular wall; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; EPHB-mediated forward signaling; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Attachment and Entry; Retinoid metabolism and transport; Syndecan interactions"	"16"	"0"	"6.6"	"5.4"	"5.7"	"6.9"	"5.8"	"8.7"	"25.3"	"17.6"	"16.2"	"19.1"	"27.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82673"	"28S ribosomal protein S35, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1"	"3"	"1"	"1"	"1"	"323"	"36.8"	"8.24"	"335.69"	""	"1"	""	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"other molecular function"	"Pf10213"	"60488"	"ENSG00000061794"	"MRPS35"	"hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"5.4"	"5.3"	"6.9"	"9.0"	"10.1"	"9.7"	"28.3"	"21.7"	"15.1"	"20.9"	"24.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"B7ZAP0"	"Rab GTPase-activating protein 1-like, isoform 10 OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1"	"4"	"1"	"1"	"1"	"253"	"29.0"	"5.33"	"335.00"	""	"1"	""	""	""	""	""	"9910"	"ENSG00000152061"	"RABGAP1L"	"B7ZAA4; B7ZAP0; hsa:9910"	""	""	"0"	"0"	"152.3"	"74.0"	"153.3"	"211.3"	"266.2"	"215.1"	"534.4"	"484.3"	"263.5"	"397.4"	"458.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00442"	"RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1"	"3"	"1"	"1"	"1"	"366"	"39.3"	"7.85"	"332.84"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"other molecular function"	"Pf01137, Pf05189"	"8634"	"ENSG00000137996"	"RTCA"	"hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99"	""	""	"0"	"0"	"6.2"	"3.2"	"7.0"	"12.7"	"15.7"	"11.8"	"24.1"	"31.5"	"14.8"	"28.4"	"76.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y266"	"Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1"	"5"	"1"	"1"	"1"	"331"	"38.2"	"5.38"	"327.11"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf04969, Pf14050, Pf16273"	"10726"	"ENSG00000090273"	"NUDC"	"hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6"	"Ciliary landscape; PAFAH1B1 copy number variation"	"Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; RND2 GTPase cycle"	"9"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BT40"	"Inositol polyphosphate 5-phosphatase K OS=Homo sapiens OX=9606 GN=INPP5K PE=1 SV=3"	"2"	"1"	"1"	"1"	"448"	"51.1"	"6.54"	"309.97"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf03372, Pf17751"	"51763"	"ENSG00000132376"	"INPP5K"	"B2R6I2; B2R750; D3DTH8; hsa:51763; Q15733; Q9BT40; Q9NPJ5; Q9P2R5"	"Notch signaling; VEGFA-VEGFR2 signaling; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome"	"Synthesis of PIPs at the plasma membrane"	"4"	"0"	"63.6"	"33.2"	"64.0"	"96.5"	"131.5"	"87.6"	"230.3"	"242.0"	"174.6"	"230.2"	"245.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P78344"	"Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1"	"1"	"1"	"1"	"1"	"907"	"102.3"	"7.14"	"301.33"	""	"1"	""	"protein metabolism;other metabolic processes;other biological processes"	"cytosol;translational apparatus"	"nucleic acid binding activity"	"Pf02020, Pf02847, Pf02854"	"1982"	"ENSG00000110321"	"EIF4G2"	"hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16"	"VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis"	"ISG15 antiviral mechanism"	"4"	"0"	"15.1"	"10.2"	"14.6"	"26.8"	"31.6"	"27.2"	"45.2"	"51.9"	"35.2"	"41.0"	"56.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q92686"	"Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1"	"19"	"1"	"1"	"1"	"78"	"7.6"	"7.87"	"295.24"	""	"1"	""	"developmental processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component"	"other molecular function"	"Pf00612"	"4900"	"ENSG00000154146"	"NRGN"	"hsa:4900; Q92686"	""	"Long-term potentiation"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WUB8"	"PHD finger protein 10 OS=Homo sapiens OX=9606 GN=PHF10 PE=1 SV=3"	"2"	"1"	"1"	"1"	"498"	"56.0"	"6.62"	"293.61"	""	"1"	""	"cell organization and biogenesis;developmental processes;other biological processes"	"nucleus;other cell component"	"other molecular function"	"Pf00628"	"55274"	"ENSG00000130024"	"PHF10"	"hsa:55274; Q2YDA3; Q53HG8; Q8WUB8; Q9BXD2; Q9NV26"	""	""	"0"	"0"	"49.7"	"48.1"	"59.8"	"84.1"	"109.3"	"93.5"	"190.8"	"189.1"	"143.6"	"160.8"	"203.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q969E8"	"Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1"	"4"	"1"	"1"	"1"	"191"	"20.9"	"4.39"	"289.89"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	""	"Pf10273"	"90121"	"ENSG00000158526"	"TSR2"	"hsa:90121; Q969E8"	""	""	"0"	"0"	"29.8"	"17.6"	"27.8"	"35.8"	"45.2"	"46.9"	"89.4"	"85.4"	"57.3"	"70.8"	"84.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NPA8"	"Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1"	"7"	"1"	"1"	"1"	"101"	"11.5"	"9.33"	"285.14"	""	"1"	""	"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes"	"mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf10163"	"56943"	"ENSG00000120533"	"ENY2"	"B2RE52; G3V117; hsa:56943; Q9NPA8"	""	"HATs acetylate histones"	"1"	"0"	"72.1"	"56.1"	"80.9"	"104.4"	"130.3"	"120.9"	"317.3"	"296.2"	"203.9"	"310.3"	"409.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P18846"	"Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2"	"3"	"1"	"1"	"1"	"271"	"29.2"	"8.37"	"277.44"	""	"1"	""	"cell organization and biogenesis;signal transduction;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00170, Pf02173"	"466"	"ENSG00000123268"	"ATF1"	"B4DRF9; hsa:466; P18846; P25168; Q9H4A8"	"Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling"	"NGF-stimulated transcription; CREB phosphorylation"	"9"	"0"	"53.4"	"29.0"	"47.5"	"101.1"	"120.0"	"102.4"	"239.7"	"241.0"	"99.0"	"162.0"	"254.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75334"	"Liprin-alpha-2 OS=Homo sapiens OX=9606 GN=PPFIA2 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1257"	"143.2"	"6.11"	"274.94"	""	"1"	""	"cell adhesion;cell organization and biogenesis;transport;other biological processes"	"cytosol;other cell component"	""	"Pf00536, Pf07647"	"8499"	"ENSG00000139220"	"PPFIA2"	"B3KVT5; B3KXA0; B7Z2A6; B7Z3U9; B7Z663; B7ZKZ5; E7ERB8; E7ETG6; F8VP68; hsa:8499; O75334; Q2M3G8"	""	"Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases"	"6"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"High"	"n/a"	"High"	"n/a"	"n/a"	"High"	"High"	"n/a"	"n/a"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"P43307"	"Translocon-associated protein subunit alpha OS=Homo sapiens OX=9606 GN=SSR1 PE=1 SV=3"	"3"	"1"	"1"	"1"	"286"	"32.2"	"4.49"	"274.65"	""	"1"	""	"transport;other biological processes"	"other membranes;ER/Golgi"	""	"Pf03896"	"6745"	"ENSG00000124783"	"SSR1"	"A8K685; hsa:6745; P43307; Q53GX2; Q53H19; Q5TAM3; Q6IB43; Q8NBH9; Q96IA2; Q9TNQ8; Q9UN49"	""	"XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane"	"2"	"0"	"38.4"	"32.6"	"39.3"	"60.8"	"77.4"	"58.8"	"113.4"	"112.5"	"62.3"	"89.4"	"124.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3B2"	"Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1"	"6"	"1"	"1"	"1"	"195"	"21.4"	"8.24"	"272.16"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cytoplasmic organelle;other cell component"	"nucleic acid binding activity"	"Pf10447, Pf14382"	"51013"	"ENSG00000171311"	"EXOSC1"	"B2R9B3; hsa:51013; Q5JTH3; Q9Y3B2"	""	"Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease"	"6"	"0"	"7.9"	"0.0"	"5.9"	"9.8"	"9.5"	"8.1"	"22.1"	"22.5"	"17.9"	"17.8"	"23.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O76094"	"Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3"	"2"	"1"	"1"	"1"	"671"	"74.6"	"9.26"	"272.15"	""	"1"	""	"transport"	"cytosol;ER/Golgi;translational apparatus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf08492, Pf13181, Pf17004"	"6731"	"ENSG00000174780"	"SRP72"	"G5E9Z8; hsa:6731; O76094; Q7Z3C0"	""	"SRP-dependent cotranslational protein targeting to membrane"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BZL1"	"Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1"	"14"	"1"	"1"	"1"	"73"	"8.5"	"8.44"	"271.41"	""	"1"	""	"protein metabolism;RNA metabolism OR transcription;other metabolic processes"	"nucleus;other cell component"	"other molecular function"	"Pf00240"	"59286"	"ENSG00000198258"	"UBL5"	"hsa:59286; Q2NL89; Q9BZL1"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"10.3"	"7.3"	"5.2"	"11.2"	"16.7"	"13.0"	"24.4"	"23.4"	"23.4"	"21.8"	"54.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96DE0"	"U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2"	"8"	"1"	"1"	"1"	"195"	"21.3"	"6.89"	"271.25"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00293"	"131870"	"ENSG00000198585"	"NUDT16"	"B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82"	""	"Phosphate bond hydrolysis by NUDT proteins"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"1"	""
"False"	"IsMasterProtein"	"Q9BVC5"	"Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1"	"7"	"1"	"1"	"1"	"232"	"25.8"	"9.74"	"270.17"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes;developmental processes"	"nucleus;other cell component"	""	"Pf15323"	"79074"	"ENSG00000135974"	"C2orf49"	"B3KXN3; B4E2G9; hsa:79074; Q9BVC5"	""	"tRNA processing in the nucleus"	"1"	"0"	"8.3"	"4.8"	"9.4"	"8.8"	"12.2"	"10.3"	"31.7"	"31.9"	"16.8"	"22.8"	"24.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8TF01"	"Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2"	"2"	"1"	"1"	"1"	"805"	"92.5"	"10.02"	"268.75"	""	"1"	""	""	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	""	"Pf15996"	"25957"	"ENSG00000132424"	"PNISR"	"A8K540; E1P5D2; hsa:25957; Q5T064; Q5T065; Q6P2B4; Q6P2N4; Q6PJ93; Q6PK36; Q7Z640; Q8N2L1; Q8TF00; Q8TF01; Q96K10; Q96SI3; Q96SM5; Q9P076; Q9P0C0; Q9Y4N3"	""	""	"0"	"0"	"7.5"	"4.2"	"11.4"	"16.1"	"17.4"	"19.8"	"31.7"	"32.3"	"26.7"	"37.3"	"47.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q2TAA2"	"Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1"	"5"	"1"	"1"	"1"	"248"	"27.6"	"5.30"	"264.94"	""	"1"	""	"other metabolic processes"	""	"other molecular function"	"Pf13472"	"285148"	"ENSG00000134330"	"IAH1"	"B4DMV3; hsa:285148; Q2TAA2"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P06746"	"DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3"	"2"	"1"	"1"	"1"	"335"	"38.2"	"8.95"	"264.39"	""	"1"	""	"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes"	"cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;nucleic acid binding activity;other molecular function"	"Pf10391, Pf14716, Pf14791, Pf14792"	"5423"	"ENSG00000070501"	"POLB"	"B2RC78; hsa:5423; P06746; Q3KP48; Q6FI34"	"Male infertility; Base excision repair; DNA repair pathways, full network"	"Ub-specific processing proteases; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"	"10"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q659A1"	"Little elongation complex subunit 2 OS=Homo sapiens OX=9606 GN=ICE2 PE=1 SV=2"	"1"	"1"	"1"	"1"	"982"	"109.9"	"7.09"	"263.51"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes;other biological processes"	"cytosol;nucleus;other cell component"	""	"Pf10505"	"79664"	"ENSG00000128915"	"ICE2"	"B2RU08; hsa:79664; Q05CT1; Q3B7W6; Q63HP4; Q658Q0; Q659A1; Q68CN8; Q6IPW7; Q6UX23; Q71H65; Q96CY5; Q9HAA2"	""	"RNA polymerase II transcribes snRNA genes"	"1"	"0"	"8.3"	"5.4"	"5.9"	"13.5"	"19.3"	"10.9"	"52.5"	"45.9"	"22.7"	"37.0"	"37.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HD67"	"Unconventional myosin-X OS=Homo sapiens OX=9606 GN=MYO10 PE=1 SV=3"	"0"	"1"	"1"	"1"	"2058"	"237.2"	"6.21"	"262.98"	""	"1"	""	"transport;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf00063, Pf00169, Pf00373, Pf00612, Pf00784, Pf00788, Pf16735, Pf18597"	"4651"	"ENSG00000145555"	"MYO10"	"A7E2D1; hsa:4651; O94893; Q8IVX5; Q9HD67; Q9NYM7; Q9P110; Q9P111; Q9UHF6"	""	"Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Netrin-1 signaling"	"3"	"0"	"57.1"	"37.1"	"72.9"	"100.3"	"124.5"	"109.5"	"337.2"	"337.6"	"169.7"	"216.2"	"335.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13617"	"Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2"	"1"	"1"	"1"	"1"	"745"	"86.9"	"6.92"	"261.53"	""	"1"	""	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction"	"cytosol;nucleus;other cell component"	"other molecular function"	"Pf00888, Pf10557"	"8453"	"ENSG00000108094"	"CUL2"	"B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9"	"Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2"	"Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation"	"6"	"0"	"7.7"	"5.6"	"6.2"	"12.7"	"12.6"	"12.0"	"25.8"	"16.5"	"10.4"	"13.6"	"18.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H2J4"	"Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1"	"5"	"1"	"1"	"1"	"239"	"27.6"	"4.84"	"260.15"	""	"1"	""	"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes"	"cytosol;ER/Golgi;nucleus;other cell component"	"signal transduction activity or receptor binding;other molecular function"	"Pf02114"	"79031"	"ENSG00000115539"	"PDCL3"	"B2RA00; hsa:79031; Q53S68; Q9H2J4"	""	""	"0"	"0"	"15.0"	"8.4"	"15.1"	"18.4"	"22.5"	"21.0"	"47.2"	"54.3"	"37.4"	"43.4"	"61.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NX07"	"tRNA selenocysteine 1-associated protein 1 OS=Homo sapiens OX=9606 GN=TRNAU1AP PE=1 SV=1"	"2"	"1"	"1"	"1"	"287"	"32.5"	"4.74"	"259.73"	""	"1"	""	"protein metabolism;other metabolic processes"	"nucleus;other cell component"	"nucleic acid binding activity"	"Pf00076, Pf17654"	"54952"	"ENSG00000180098"	"TRNAU1AP"	"hsa:54952; Q86SU7; Q9NX07"	""	""	"0"	"0"	"9.7"	"6.4"	"8.1"	"18.0"	"19.4"	"17.0"	"33.7"	"27.5"	"15.1"	"18.0"	"25.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9H0U9"	"Testis-specific Y-encoded-like protein 1 OS=Homo sapiens OX=9606 GN=TSPYL1 PE=1 SV=3"	"3"	"1"	"1"	"1"	"437"	"49.2"	"5.45"	"259.23"	""	"1"	""	"cell organization and biogenesis"	"nucleus;other cell component"	"other molecular function"	"Pf00956"	"7259"	"ENSG00000189241"	"TSPYL1"	"hsa:7259; O75885; Q5TFE6; Q9H0U9"	"Sudden infant death syndrome (SIDS) susceptibility pathways"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O00487"	"26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1"	"2"	"1"	"1"	"1"	"310"	"34.6"	"6.52"	"258.57"	""	"1"	""	"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes"	"non-structural extracellular;cytosol;nucleus;other cell component"	"enzyme regulator activity;other molecular function"	"Pf01398, Pf13012"	"10213"	"ENSG00000115233"	"PSMD14"	"B3KNW2; hsa:10213; O00176; O00487"	"Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease"	"Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs"	"64"	"0"	"38.7"	"36.7"	"35.4"	"59.6"	"77.4"	"70.0"	"83.5"	"98.0"	"53.0"	"80.1"	"90.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75832"	"26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1"	"3"	"1"	"1"	"1"	"226"	"24.4"	"6.10"	"257.31"	""	"1"	""	"cell organization and biogenesis;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"cytoskeletal activity;other molecular function"	"Pf12796"	"5716"	"ENSG00000101843"	"PSMD10"	"hsa:5716; O75832; Q5U0B2; Q8IZK9"	"Proteasome degradation; Parkin-ubiquitin proteasomal system pathway"	"FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"	"61"	"0"	"87.1"	"52.4"	"81.3"	"96.9"	"112.0"	"114.0"	"209.0"	"180.4"	"93.0"	"163.2"	"253.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P62310"	"U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2"	"8"	"1"	"1"	"1"	"102"	"11.8"	"4.70"	"256.56"	""	"1"	""	"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity"	"Pf01423"	"27258"	"ENSG00000170860"	"LSM3"	"hsa:27258; P62310; Q6IAH0; Q9Y4Z1"	""	"mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease"	"2"	"0"	"51.5"	"32.8"	"57.9"	"70.4"	"78.5"	"80.3"	"273.5"	"274.8"	"138.1"	"188.3"	"199.2"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NW82"	"WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1"	"2"	"1"	"1"	"1"	"654"	"73.2"	"6.33"	"256.36"	""	"1"	""	""	"nucleus;other cell component"	"other molecular function"	"Pf00400"	"55100"	"ENSG00000082068"	"WDR70"	"hsa:55100; Q9H053; Q9NW82"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"6.7"	"3.4"	"5.8"	"10.2"	"14.1"	"9.6"	"29.6"	"28.5"	"18.7"	"20.2"	"22.6"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96FS4"	"Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1"	"1"	"1"	"1"	"1"	"1042"	"112.1"	"6.60"	"254.93"	""	"1"	""	"cell organization and biogenesis;stress response;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component"	"enzyme regulator activity"	"Pf00595, Pf02145"	"6494"	"ENSG00000213445"	"SIPA1"	"hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4"	"MAPK cascade"	"Rap1 signalling"	"2"	"0"	"3.0"	"4.7"	"3.4"	"6.9"	"6.4"	"5.1"	"23.7"	"19.4"	"9.9"	"16.2"	"15.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5T011"	"KICSTOR complex protein SZT2 OS=Homo sapiens OX=9606 GN=SZT2 PE=1 SV=3"	"0"	"1"	"1"	"1"	"3432"	"377.8"	"6.27"	"254.81"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes"	"other membranes;other cytoplasmic organelle;other cell component"	""	""	"23334"	"ENSG00000198198"	"SZT2"	"A0PJK5; A7E2X4; hsa:23334; O75055; Q5JUY7; Q5T011; Q5T012; Q5XKC7; Q6ZNI8; Q6ZT24; Q7Z636; Q8NAY9; Q9H5H7; Q9UFQ8"	""	"Amino acids regulate mTORC1"	"1"	"0"	"23.6"	"16.6"	"20.6"	"34.3"	"38.5"	"35.3"	"71.4"	"57.8"	"37.4"	"45.7"	"51.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75376"	"Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2"	"0"	"1"	"1"	"1"	"2440"	"270.0"	"7.11"	"254.53"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes"	"cytosol;cytoskeleton;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00249, Pf15784"	"9611"	"ENSG00000141027"	"NCOR1"	"B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18"	"Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway"	"PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"	"30"	"0"	"21.9"	"14.3"	"21.0"	"40.7"	"49.6"	"42.7"	"56.7"	"47.5"	"32.6"	"53.6"	"71.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q08J23"	"RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2"	"2"	"1"	"1"	"1"	"767"	"86.4"	"6.77"	"254.48"	""	"1"	""	"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes"	"non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf01189"	"54888"	"ENSG00000037474"	"NSUN2"	"A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9"	""	"tRNA modification in the nucleus and cytosol"	"1"	"0"	"6.2"	"3.0"	"3.9"	"8.0"	"8.2"	"6.9"	"28.4"	"22.9"	"11.0"	"17.0"	"22.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UQ84"	"Exonuclease 1 OS=Homo sapiens OX=9606 GN=EXO1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"846"	"94.0"	"8.31"	"253.84"	""	"1"	""	"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes"	"plasma membrane;other membranes;nucleus"	"nucleic acid binding activity;other molecular function"	"Pf00752, Pf00867"	"9156"	"ENSG00000174371"	"EXO1"	"hsa:9156; O60545; O75214; O75466; Q5T396; Q96IJ1; Q9UG38; Q9UNW0; Q9UQ84"	"DNA repair pathways, full network; DNA mismatch repair; Primary ovarian insufficiency"	"Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"	"19"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q0ZGT2"	"Nexilin OS=Homo sapiens OX=9606 GN=NEXN PE=1 SV=1"	"1"	"1"	"1"	"1"	"675"	"80.6"	"5.33"	"253.76"	""	"1"	""	"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes"	"plasma membrane;other membranes;cytoskeleton;other cell component"	"cytoskeletal activity;other molecular function"	"Pf07679"	"91624"	"ENSG00000162614"	"NEXN"	"A0PJ84; B4DPZ7; hsa:91624; Q0D2H2; Q0ZGT2; Q14CC2; Q14CC3; Q16081; Q7Z2X0; Q96DL0; Q9Y2V1"	"VEGFA-VEGFR2 signaling"	""	"1"	"0"	"51.4"	"39.0"	"50.2"	"66.4"	"84.9"	"71.8"	"154.2"	"151.6"	"111.2"	"157.6"	"182.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BRR8"	"G patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GPATCH1 PE=1 SV=1"	"1"	"1"	"1"	"1"	"931"	"103.3"	"7.05"	"253.53"	""	"1"	""	"RNA metabolism OR transcription;other metabolic processes"	"nucleus"	"nucleic acid binding activity"	"Pf01585, Pf07713"	"55094"	"ENSG00000076650"	"GPATCH1"	"hsa:55094; Q8IZV6; Q8N3B7; Q9BRR8; Q9NW94"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O75487"	"Glypican-4 OS=Homo sapiens OX=9606 GN=GPC4 PE=1 SV=4"	"1"	"1"	"1"	"1"	"556"	"62.4"	"6.68"	"253.13"	""	"1"	""	"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes"	"extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component"	""	"Pf01153"	"2239"	"ENSG00000076716"	"GPC4"	"B2R6J7; B4E2C0; hsa:2239; O75487; Q6ZMA6; Q96L43; Q9NU08; Q9UJN1; Q9UPD9"	"Wnt signaling"	"A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Attachment and Entry; Retinoid metabolism and transport"	"11"	"0"	"13.3"	"4.2"	"8.2"	"10.3"	"12.6"	"13.4"	"66.9"	"52.9"	"43.6"	"48.0"	"40.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q13084"	"39S ribosomal protein L28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4"	"2"	"1"	"1"	"1"	"256"	"30.1"	"8.29"	"252.73"	""	"1"	""	"protein metabolism;other metabolic processes"	"other membranes;cytosol;mitochondrion;translational apparatus"	"other molecular function"	"Pf00830"	"10573"	"ENSG00000086504"	"MRPL28"	"B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"19.5"	"16.1"	"14.7"	"30.3"	"34.2"	"27.5"	"74.0"	"68.9"	"43.3"	"54.1"	"68.7"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P42356"	"Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4"	"1"	"1"	"1"	"1"	"2102"	"236.7"	"7.06"	"251.34"	""	"1"	""	"other metabolic processes;signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;ER/Golgi;other cell component"	"kinase activity;other molecular function"	"Pf00454, Pf00613, Pf19274"	"5297"	"ENSG00000241973"	"PI4KA"	"hsa:5297; P42356; Q7Z625; Q9UPG2"	"Ectoderm differentiation; 22q11.2 copy number variation syndrome"	"Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane"	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q86XH1"	"Dynein regulatory complex protein 11 OS=Homo sapiens OX=9606 GN=IQCA1 PE=2 SV=1"	"1"	"1"	"1"	"1"	"822"	"95.3"	"9.47"	"251.19"	""	"1"	""	"cell organization and biogenesis"	"cytoskeleton;other cell component"	"other molecular function"	"Pf00004"	"79781"	"ENSG00000132321"	"IQCA1"	"B4DFH9; E7EWQ0; hsa:79781; Q4G164; Q53R37; Q53RV3; Q86XH1; Q96NS7; Q9H680"	"2q37 copy number variation syndrome"	""	"1"	"0"	"44.6"	"26.0"	"41.6"	"66.5"	"80.5"	"63.6"	"147.2"	"133.0"	"101.7"	"140.7"	"191.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q15435"	"Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1"	"3"	"1"	"1"	"1"	"360"	"41.5"	"4.91"	"250.69"	""	"1"	""	"other biological processes"	"other cell component"	"enzyme regulator activity"	"Pf14580"	"5510"	"ENSG00000115685"	"PPP1R7"	"B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4"	"2q37 copy number variation syndrome"	""	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9P2K5"	"Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3"	"2"	"1"	"1"	"1"	"600"	"64.1"	"8.75"	"250.49"	""	"1"	""	"developmental processes;other biological processes"	"nucleus"	"nucleic acid binding activity"	"Pf00076"	"50804"	"ENSG00000104177"	"MYEF2"	"A7MCZ9; C9J921; C9K0J4; hsa:50804; Q6NUM5; Q7L388; Q7Z4B7; Q9H922; Q9NUQ1; Q9P2K5"	"Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression"	""	"4"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P52565"	"Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3"	"3"	"1"	"1"	"1"	"204"	"23.2"	"5.11"	"250.39"	""	"1"	""	"signal transduction;other biological processes"	"plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component"	"enzyme regulator activity"	"Pf02115"	"396"	"ENSG00000141522"	"ARHGDIA"	"A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5"	"Ciliary landscape; Nephrotic syndrome"	"CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)"	"11"	"0"	"26.0"	"37.7"	"34.0"	"30.3"	"53.8"	"69.0"	"101.6"	"80.5"	"74.2"	"100.8"	"231.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9C099"	"Leucine-rich repeat and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LRRCC1 PE=1 SV=2"	"1"	"1"	"1"	"1"	"1032"	"119.5"	"5.88"	"250.01"	""	"1"	""	"cell cycle OR cell proliferation;other biological processes"	"cytoskeleton;other cell component"	""	""	"85444"	"ENSG00000133739"	"LRRCC1"	"B4DYX6; B5RI11; hsa:85444; Q8N768; Q96DK7; Q96N01; Q9C099"	""	""	"0"	"0"	"94.7"	"51.3"	"77.9"	"110.4"	"113.7"	"101.2"	"502.9"	"506.4"	"352.3"	"386.5"	"645.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRL2"	"Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2"	"1"	"1"	"1"	"1"	"1556"	"178.6"	"6.60"	"249.34"	""	"1"	""	"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00439, Pf00628, Pf02791, Pf10537, Pf15612, Pf15613"	"11177"	"ENSG00000198604"	"BAZ1A"	"hsa:11177; Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3"	"Ectoderm differentiation"	""	"1"	"0"	"2.6"	"0.0"	"2.9"	"3.4"	"6.8"	"4.8"	"26.8"	"25.9"	"20.7"	"19.3"	"51.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"n/a"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q96HT8"	"MORF4 family-associated protein 1-like 1 OS=Homo sapiens OX=9606 GN=MRFAP1L1 PE=1 SV=1"	"9"	"1"	"1"	"1"	"127"	"14.8"	"4.49"	"248.28"	""	"1"	""	""	""	"other molecular function"	"Pf15155"	"114932"	"ENSG00000178988"	"MRFAP1L1"	"B2R6R0; hsa:114932; Q6NXT8; Q96HT8; Q9P0J5"	""	""	"0"	"0"	"20.5"	"13.2"	"19.6"	"38.5"	"39.3"	"35.9"	"66.3"	"57.9"	"41.8"	"42.0"	"75.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8N4H5"	"Mitochondrial import receptor subunit TOM5 homolog OS=Homo sapiens OX=9606 GN=TOMM5 PE=1 SV=1"	"14"	"1"	"1"	"1"	"51"	"6.0"	"9.70"	"247.78"	""	"1"	""	"cell organization and biogenesis;transport"	"other membranes;mitochondrion"	""	"Pf10642"	"401505"	"ENSG00000175768"	"TOMM5"	"B2DG07; F6S928; hsa:401505; Q5JRT7; Q8N4H5"	""	"Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy"	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y2Q5"	"Ragulator complex protein LAMTOR2 OS=Homo sapiens OX=9606 GN=LAMTOR2 PE=1 SV=1"	"9"	"1"	"1"	"1"	"125"	"13.5"	"5.40"	"246.82"	""	"1"	""	"signal transduction;other biological processes"	"plasma membrane;other membranes;other cytoplasmic organelle"	"enzyme regulator activity;other molecular function"	"Pf03259"	"28956"	"ENSG00000116586"	"LAMTOR2"	"hsa:28956; Q5VY97; Q5VY98; Q5VY99; Q9Y2Q5"	""	"Neutrophil degranulation; MAP2K and MAPK activation; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK"	"9"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q14135"	"Transcription cofactor vestigial-like protein 4 OS=Homo sapiens OX=9606 GN=VGLL4 PE=1 SV=4"	"6"	"1"	"1"	"1"	"290"	"30.9"	"8.22"	"246.40"	""	"1"	""	"other biological processes"	"nucleus"	"other molecular function"	"Pf15245"	"9686"	"ENSG00000144560"	"VGLL4"	"B4DTS7; hsa:9686; J3KN68; Q14135; Q7L5V0; Q9BQ78"	"Hippo-Merlin signaling dysregulation; Pleural mesothelioma"	""	"2"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q5VZE5"	"N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1"	"2"	"1"	"1"	"1"	"725"	"83.6"	"7.05"	"244.71"	""	"1"	""	"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes"	"plasma membrane;other membranes;cytosol;nucleus;other cell component"	""	"Pf04112"	"60560"	"ENSG00000135040"	"NAA35"	"hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703"	""	"Retrograde transport at the Trans-Golgi-Network"	"1"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"O95759"	"TBC1 domain family member 8 OS=Homo sapiens OX=9606 GN=TBC1D8 PE=1 SV=3"	"1"	"1"	"1"	"1"	"1140"	"130.8"	"5.52"	"243.22"	""	"1"	""	"other biological processes"	"other membranes"	"enzyme regulator activity"	"Pf00566, Pf02893"	"11138"	"ENSG00000204634"	"TBC1D8"	"A6NDL4; A8K9W1; B9A6K4; hsa:11138; O95759; Q53SQ4; Q9UQ32"	""	""	"0"	"0"	"9.3"	"3.7"	"7.1"	"10.6"	"11.6"	"10.8"	"102.1"	"296.4"	"488.8"	"905.9"	"1460.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9Y3D9"	"28S ribosomal protein S23, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2"	"5"	"1"	"1"	"1"	"190"	"21.8"	"8.90"	"241.89"	""	"1"	""	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus;nucleus"	"other molecular function"	"Pf10484"	"51649"	"ENSG00000181610"	"MRPS23"	"B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"13.8"	"16.1"	"15.6"	"22.5"	"29.0"	"20.6"	"49.7"	"44.5"	"41.0"	"39.1"	"50.9"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"P82932"	"28S ribosomal protein S6, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3"	"10"	"1"	"1"	"1"	"125"	"14.2"	"9.26"	"240.68"	""	"1"	""	"protein metabolism;other metabolic processes"	"other membranes;mitochondrion;translational apparatus"	"nucleic acid binding activity;other molecular function"	"Pf01250"	"64968"	"ENSG00000243927"	"MRPS6"	"B2R573; hsa:64968; P82932; Q96Q64; Q9BSK8; Q9BW89"	""	"Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination"	"3"	"0"	"11.0"	"3.9"	"1.5"	"10.0"	"10.9"	"11.1"	"20.5"	"18.3"	"24.9"	"18.7"	"14.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9UBI6"	"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 OS=Homo sapiens OX=9606 GN=GNG12 PE=1 SV=3"	"10"	"1"	"1"	"1"	"72"	"8.0"	"8.97"	"240.23"	""	"1"	""	"signal transduction"	"plasma membrane;other membranes"	"other molecular function"	"Pf00631"	"55970"	"ENSG00000172380"	"GNG12"	"hsa:55970; Q69YP5; Q9BRV5; Q9UBI6"	"Myometrial relaxation and contraction pathways; G protein signaling pathways; MAPK signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Regulation of actin cytoskeleton; Calcium regulation in cardiac cells"	"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation"	"37"	"0"	"107.4"	"85.4"	"95.3"	"98.1"	"128.6"	"125.9"	"203.6"	"222.7"	"141.9"	"188.7"	"233.1"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q3B7T1"	"Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1"	"0"	"1"	"1"	"1"	"1238"	"138.4"	"6.33"	"238.93"	""	"1"	""	"other biological processes"	"nucleus"	""	""	"26098"	"ENSG00000107938"	"EDRF1"	"B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4"	""	""	"0"	"0"	"6.1"	"5.3"	"8.2"	"10.5"	"16.3"	"14.7"	"39.1"	"25.2"	"16.0"	"22.7"	"29.5"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q8WUD4"	"Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1"	"4"	"1"	"1"	"1"	"166"	"19.2"	"7.34"	"236.12"	""	"1"	""	""	"nucleus"	""	"Pf08315"	"151903"	"ENSG00000160799"	"CCDC12"	"hsa:151903; Q8N8I4; Q8WUD4"	""	"mRNA Splicing - Major Pathway"	"1"	"0"	"39.6"	"27.3"	"38.1"	"64.2"	"88.0"	"76.2"	"189.1"	"183.0"	"144.1"	"187.1"	"210.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9HC38"	"Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1"	"4"	"1"	"1"	"1"	"313"	"34.8"	"5.60"	"234.85"	""	"1"	""	""	"mitochondrion"	""	""	"51031"	"ENSG00000167699"	"GLOD4"	"D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1"	""	""	"0"	"0"	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	""	"n/a"	"n/a"	"n/a"	"n/a"	"High"	"n/a"	"High"	"n/a"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q16719"	"Kynureninase OS=Homo sapiens OX=9606 GN=KYNU PE=1 SV=1"	"1"	"1"	"1"	"1"	"465"	"52.3"	"7.03"	"234.82"	""	"1"	""	"other metabolic processes;stress response;other biological processes"	"cytosol;mitochondrion;nucleus;other cell component"	"other molecular function"	"Pf00266"	"8942"	"ENSG00000115919"	"KYNU"	"B2RCZ5; D3DP79; hsa:8942; Q16719; Q6I9T2; Q9BVW3"	"Selenium micronutrient network; NAD biosynthesis II (from tryptophan); Tryptophan metabolism"	"Tryptophan catabolism"	"4"	"0"	"45.6"	"22.6"	"33.8"	"43.6"	"60.0"	"55.9"	"109.2"	"101.7"	"72.2"	"63.6"	"96.3"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9NRG0"	"Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1"	"6"	"1"	"1"	"1"	"131"	"14.7"	"5.10"	"234.62"	""	"1"	""	"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes"	"nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00808"	"54108"	"ENSG00000104472"	"CHRAC1"	"hsa:54108; Q9NRG0"	"Acute viral myocarditis"	""	"1"	"0"	"22.6"	"22.0"	"20.9"	"25.0"	"28.2"	"25.1"	"58.0"	"47.2"	"34.4"	"41.8"	"55.4"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"A0A024RBG1"	"Diphosphoinositol polyphosphate phosphohydrolase NUDT4B OS=Homo sapiens OX=9606 GN=NUDT4B PE=3 SV=1"	"3"	"1"	"1"	"1"	"181"	"20.4"	"6.35"	"234.37"	""	"1"	""	"other metabolic processes"	"cytosol;nucleus;other cell component"	"nucleic acid binding activity;other molecular function"	"Pf00293"	"11163"	"ENSG00000177144"	"NUDT4B"	"A0A024RBG1"	""	""	"0"	"0"	"38.0"	"27.1"	"48.0"	"61.3"	"65.3"	"62.8"	"181.8"	"220.1"	"146.5"	"239.3"	"359.0"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""
"False"	"IsMasterProtein"	"Q9BX84"	"Transient receptor potential cation channel subfamily M member 6 OS=Homo sapiens OX=9606 GN=TRPM6 PE=1 SV=2"	"0"	"1"	"1"	"1"	"2022"	"231.6"	"7.77"	"233.96"	""	"1"	""	"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes"	"plasma membrane;other membranes"	"transporter activity;kinase activity;other molecular function"	"Pf00520, Pf02816, Pf16519, Pf18139"	"140803"	"ENSG00000119121"	"TRPM6"	"hsa:140803; Q6VPR8; Q6VPR9; Q6VPS0; Q6VPS1; Q6VPS2; Q9BX84"	""	"TRP channels"	"1"	"0"	"25.2"	"15.9"	"22.9"	"28.2"	"43.9"	"40.2"	"71.6"	"74.0"	"45.9"	"69.7"	"112.8"	""	""	""	""	""	""	""	""	""	""	""	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"High"	"1"	""