Entry Entry Name Protein names Gene Names Organism Gene Ontology (biological process) Gene Ontology (cellular component) Gene Ontology (molecular function) N: Peptides N: Sequence coverage [%] N: Q-value N: Score T: Peptide sequences CNA-1 CNA-2 CNA-3 CPA-1 CPA-2 CPA-3 CPN-1 CPN-2 CPN-3 NNA-1 NNA-2 NNA-3 NPA-1 NPA-2 NPA-3 NPN-1 NPN-2 NPN-3 label CNA CNA CNA CPA CPA CPA CPN CPN CPN NNA NNA NNA NPA NPA NPA NPN NPN NPN A0A0A1CEZ7 A0A0A1CEZ7_HOLGL Klf1/2/4 Holothuria glaberrima (Brown rock sea cucumber) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 2.5 0.95224 -0.068637 GPHMSLLT 21.7786 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0AA48P7H3 A0AA48P7H3_HOLGL Protein Wnt Holothuria glaberrima (Brown rock sea cucumber) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576]; membrane [GO:0016020] 1 2.6 0.9875 -0.39854 PLKRPRRPKP 0 0 0 0 0 0 0 0 0 0 25.8994 25.8994 22.4617 0 0 0 0 0 A0AA48SEZ1 A0AA48SEZ1_HOLGL Protein Wnt Holothuria glaberrima (Brown rock sea cucumber) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] 1 2.1 1.0008 -23.777 NGNPSSRG 0 0 0 0 0 0 19.8553 0 0 0 0 0 0 0 0 0 0 0 A0AA48SI58 A0AA48SI58_HOLGL Protein Wnt Holothuria glaberrima (Brown rock sea cucumber) system development [GO:0048731]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] 2 4.4 0.99673 -30.026 GCDVMCCGRGYNT;SSGPDGCD 0 0 0 0 0 0 0 0 0 18.3752 25.2635 25.2635 0 0 0 0 0 0 A0A060Q0R5 A0A060Q0R5_HOLLE Protein Wnt wnt5 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] 1 4.5 1.0129 -5.2234 GTDGCDLMCCGRGYNSY 0 0 0 0 0 0 0 0 0 22.2029 24.5391 24.5391 0 0 0 0 0 0 A0A146I884 A0A146I884_HOLLE Aristaless-like homeobox protein Hlalx1 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" 1 2.9 1.0285 -23.631 PDFHCQDNGMD 0 0 0 0 0 0 19.841 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0Y8C6 A0A9Q0Y8C6_HOLLE Mitochondrial inner membrane protease subunit (EC 3.4.21.-) HOLleu_45151 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein processing involved in protein targeting to mitochondrion [GO:0006627]; signal peptide processing [GO:0006465] mitochondrial inner membrane peptidase complex [GO:0042720] serine-type endopeptidase activity [GO:0004252] 1 16.9 1.0153 -22.715 TTWKYHQLRQYVPR 0 0 0 0 0 0 17.8298 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0Y8H6 A0A9Q0Y8H6_HOLLE Sushi domain-containing protein 2 HOLleu_44946 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576]; membrane [GO:0016020] 1 2.4 0.91176 -0.068637 CGFPGKVK 0 0 0 0 0 0 0 0 0 0 0 0 0 21.651 21.651 0 0 0 A0A9Q0Y8R0 A0A9Q0Y8R0_HOLLE Zinc finger CCHC domain-containing protein 3 HOLleu_44579 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) activation of innate immune response [GO:0002218] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] 1 4.2 1.0227 -23.631 TEPNEGNTTEE 0 0 0 0 0 0 0 19.0011 19.0011 0 0 0 0 0 0 0 0 0 A0A9Q0Y8W1 A0A9Q0Y8W1_HOLLE "NACHT, LRR and PYD domains-containing protein 10" HOLleu_44440 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2 1.0113 -11.621 IIVTTVIITKRTKGKPLR 0 0 0 0 21.4738 21.4738 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0Y8Y6 A0A9Q0Y8Y6_HOLLE Uncharacterized protein HOLleu_44263 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 30.5 1.013 -10.991 MACVCMYVCM;YVCMCVCVCACV 0 22.3438 22.3438 0 0 0 0 21.6589 21.6589 20.533 0 0 15.1673 0 0 0 0 0 A0A9Q0Y996 A0A9Q0Y996_HOLLE Uncharacterized protein HOLleu_45020 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 25.8 1.0159 -16.819 QNSDHGYCFTAYQSCTA 0 0 0 0 0 0 0 20.0381 20.0381 0 0 0 0 0 0 0 0 0 A0A9Q0Y9B3 A0A9Q0Y9B3_HOLLE Uncharacterized protein HOLleu_43749 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.5 1 -4.979 PTQWVNRGPV 0 0 0 19.7991 20.4901 20.4901 0 0 0 23.1634 22.8741 22.8741 0 0 0 18.8688 0 19.4153 A0A9Q0Y9E4 A0A9Q0Y9E4_HOLLE Uncharacterized protein HOLleu_44761 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6 1.017 -2.6427 ARPKIRAPK 0 0 0 24.6175 24.4925 24.4925 0 24.0947 0 0 23.3204 23.3204 0 0 0 24.2488 21.5404 23.9516 A0A9Q0Y9F7 A0A9Q0Y9F7_HOLLE Uncharacterized protein HOLleu_44709 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0165 -2.6427 WGMTESEEG 0 22.3032 22.3032 0 0 0 0 0 0 20.8589 0 0 0 0 0 0 0 0 A0A9Q0Y9T7 A0A9Q0Y9T7_HOLLE Serum response factor-binding protein 1 HOLleu_44239 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.6 0.93769 -0.068637 RPAPAAIA 19.2651 20.8035 20.8035 0 0 0 20.3556 0 0 22.6648 22.2737 22.2737 21.9712 19.8322 19.8322 0 0 0 A0A9Q0Y9V1 A0A9Q0Y9V1_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_43029 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] membrane [GO:0016020] kinase activity [GO:0016301] 1 2.7 0.93498 -0.068637 CPAGYFGSDCTEKCLCMNNEACDRD 0 0 0 0 0 0 17.6995 18.1831 18.1831 0 0 0 0 0 0 0 0 0 A0A9Q0YA39 A0A9Q0YA39_HOLLE Immunoglobulin superfamily member 5 HOLleu_42918 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; membrane [GO:0016020] 1 2.2 1.0007 -4.979 KPLPDDDDSE 20.4997 0 0 0 0 0 0 0 0 21.6808 21.5326 21.5326 19.0803 18.6558 18.6558 0 0 0 A0A9Q0YA67 A0A9Q0YA67_HOLLE MAM and LDL-receptor class A domain-containing protein 2 HOLleu_42602 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 4 3.8 0.9968 -50.245 CDLMIDCCGDEADEDQCDDYN;DEDQCDDY;HAESQDCSSSYT;MIDCCGDEADED 21.8496 19.387 19.387 0 0 0 18.1086 0 0 0 0 0 19.723 18.5467 18.5467 0 0 0 A0A9Q0YA73 A0A9Q0YA73_HOLLE C2H2-type domain-containing protein HOLleu_43939 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1.9 1.0123 -11.832 PESMSSIEECEDTEM;SSIEECEDTEMVGC 0 23.8435 23.8435 0 0 0 24.1262 22.9508 22.9508 0 0 0 16.896 16.4034 16.4034 0 0 0 A0A9Q0YAC3 A0A9Q0YAC3_HOLLE Uncharacterized protein HOLleu_43791 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.2 1.0058 -23.777 YSCDEHAA 0 0 0 0 0 0 0 0 0 0 17.7573 17.7573 0 0 0 0 0 0 A0A9Q0YAE9 A0A9Q0YAE9_HOLLE Uncharacterized protein HOLleu_42571 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 15.3 1.0159 -16.819 HGCSGEEENCGHGQHQF 0 0 0 0 0 0 0 20.062 20.062 0 0 0 0 0 0 0 0 0 A0A9Q0YAG0 A0A9Q0YAG0_HOLLE Uncharacterized protein HOLleu_44743 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3'-5'-RNA exonuclease activity [GO:0000175] 1 6.7 1.0169 -21.924 VVCYLCDELCKFFDS 0 0 0 0 0 0 19.9872 19.3701 19.3701 0 0 0 0 0 0 0 0 0 A0A9Q0YAH4 A0A9Q0YAH4_HOLLE Peroxisomal acyl-coenzyme A oxidase 1 HOLleu_42475 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ascaroside biosynthetic process [GO:1904070]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038] peroxisome [GO:0005777] FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; palmitoyl-CoA oxidase activity [GO:0016401] 1 4.5 1.0118 -11.621 INQVDLVSKQLINLLAVI 0 0 0 0 0 0 19.5851 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YAL3 A0A9Q0YAL3_HOLLE NLR family CARD domain-containing protein 4 HOLleu_42204 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.2 1.0171 -22.715 FDEYPDQDKGYESD 0 0 0 0 0 0 18.0551 21.9194 21.9194 0 0 0 0 0 0 0 0 0 A0A9Q0YAP7 A0A9Q0YAP7_HOLLE Chromobox protein-like 7 HOLleu_42151 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7 1.008 -6.0118 VRISKLKLKFEK 0 0 0 0 0 0 0 22.4944 22.4944 0 0 0 0 0 0 0 0 0 A0A9Q0YAW2 A0A9Q0YAW2_HOLLE Uncharacterized protein HOLleu_43245 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.2 1.0293 -23.442 NIRLLLVALKNH 20.9989 0 0 19.6019 20.6108 20.6108 20.9117 20.4806 20.4806 22.7857 22.667 22.667 0 20.9719 20.9719 18.7751 0 19.5373 A0A9Q0YAX5 A0A9Q0YAX5_HOLLE PHD-type domain-containing protein HOLleu_42043 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion involved in heart morphogenesis [GO:0061343]; larval heart development [GO:0007508] extracellular matrix [GO:0031012] metal ion binding [GO:0046872] 1 6.1 1.0183 -23.723 ECEQCGSWF 0 0 0 0 0 0 15.9941 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YAZ4 A0A9Q0YAZ4_HOLLE Uncharacterized protein HOLleu_44337 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9 1 -4.979 NGEDCNCQSE 0 21.6512 21.6512 0 0 0 0 0 0 0 0 0 18.8 0 0 0 0 0 A0A9Q0YB10 A0A9Q0YB10_HOLLE BMP-binding endothelial regulator protein HOLleu_41052 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of BMP signaling pathway [GO:0030513] extracellular region [GO:0005576] BMP binding [GO:0036122] 1 1.6 1 -4.979 DSCCPVCPGC 0 0 0 0 0 0 0 0 0 0 22.0807 22.0807 0 0 0 0 0 0 A0A9Q0YB49 A0A9Q0YB49_HOLLE Uncharacterized protein HOLleu_43005 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 14 1.0027 -5.0477 GPCQGDGPCH;VGGGGSGP 0 0 0 0 0 0 0 0 0 0 0 0 0 24.6094 24.6094 0 0 0 A0A9Q0YB59 A0A9Q0YB59_HOLLE Uncharacterized protein HOLleu_44159 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3 0.1 -0.068637 SSDDDGYV 0 24.1831 24.1831 0 0 0 0 0 0 25.7284 23.8776 23.8776 0 0 0 0 0 0 A0A9Q0YBB3 A0A9Q0YBB3_HOLLE Protoporphyrinogen oxidase HOLleu_43671 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carotenoid biosynthetic process [GO:0016117] phytoene dehydrogenase activity [GO:0016166] 1 9.9 1.0139 -5.7538 RRKAYNLRRRKISDY 0 0 0 0 0 0 0 0 0 21.1859 20.6167 20.6167 0 0 0 0 0 0 A0A9Q0YBB9 A0A9Q0YBB9_HOLLE Sperm-specific antigen 2 HOLleu_41248 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor binding [GO:0005102] 1 1.5 1.0088 -5.2234 ESNPDRVDEDSEQEDNS 21.6607 26.8137 26.8137 16.2901 17.8584 17.8584 0 0 0 22.5209 22.5277 22.5277 0 18.1533 18.1533 0 0 0 A0A9Q0YBF4 A0A9Q0YBF4_HOLLE Ig-like domain-containing protein HOLleu_41101 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-cell adhesion [GO:0098609] cell-cell junction [GO:0005911]; membrane [GO:0016020] cell adhesion molecule binding [GO:0050839] 1 1.2 1.0183 -23.723 VSRQLTVKV 0 19.7182 19.7182 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YBI7 A0A9Q0YBI7_HOLLE C2H2-type domain-containing protein HOLleu_42575 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0046 -23.777 DGSPGQNA 0 0 0 0 0 0 0 20.7236 20.7236 0 0 0 0 0 0 0 0 0 A0A9Q0YBJ9 A0A9Q0YBJ9_HOLLE Trafficking kinesin-binding protein 1 HOLleu_41433 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anterograde axonal transport of mitochondrion [GO:0098957]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; protein targeting [GO:0006605]; vesicle transport along microtubule [GO:0047496] cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; mitochondrion [GO:0005739] myosin binding [GO:0017022]; signaling receptor binding [GO:0005102] 1 1.6 1.0105 -6.0779 FNSFGPGYSDEYTS 0 21.7573 21.7573 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YBM0 A0A9Q0YBM0_HOLLE Zinc finger protein Gfi-1 HOLleu_41253 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 2 3.5 1.026 -23.199 EEAVNMEQEEEEFEQEDDGDDDEDD;PEEDSDCGSDSDG 0 0 0 0 0 0 16.5488 22.3931 22.3931 0 0 0 0 0 0 0 0 0 A0A9Q0YBQ2 A0A9Q0YBQ2_HOLLE Ribonucleoside-diphosphate reductase (EC 1.17.4.1) HOLleu_43316 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260] ribonucleoside-diphosphate reductase complex [GO:0005971] "ATP binding [GO:0005524]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" 1 1.1 1.0226 -23.723 VQDPEHDWN 0 0 0 0 0 0 0 0 0 0 19.2158 19.2158 0 0 0 0 0 0 A0A9Q0YBU1 A0A9Q0YBU1_HOLLE C2H2-type domain-containing protein HOLleu_41465 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3 1.0157 -2.6427 SEEEEVCKE 0 0 0 0 0 0 21.5459 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YBU2 A0A9Q0YBU2_HOLLE Uncharacterized protein HOLleu_42200 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.9 1.0148 -2.6427 TVNCSFMTS 0 27.3778 27.3778 0 0 0 21.0893 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YBU5 A0A9Q0YBU5_HOLLE Carboxypeptidase A1 HOLleu_41490 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] 1 3.2 1.0292 -23.442 TVVFAAKDYSGF 0 0 0 0 0 0 0 0 0 0 19.8373 19.8373 0 0 0 0 0 0 A0A9Q0YBU8 A0A9Q0YBU8_HOLLE Triple functional domain protein HOLleu_41677 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] 1 0.4 1.0239 -23.675 CCEEGTGEIQ 0 0 0 0 0 0 0 0 0 0 0 0 0 16.0276 16.0276 0 0 0 A0A9Q0YBV6 A0A9Q0YBV6_HOLLE Ryncolin-4 HOLleu_45066 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 6.3 0.99788 -0.31124 CNDGYSGD;RSYYYCNYYYYYTYHYYRRCTKTN 21.0695 22.8101 22.8101 0 20.2395 20.2395 21.9238 21.41 21.41 23.5527 22.95 22.95 20.8833 20.1448 20.1448 18.6291 0 0 A0A9Q0YBY5 A0A9Q0YBY5_HOLLE Uncharacterized protein HOLleu_41607 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.2 0.93921 -0.068637 CTDCTDTQ 0 0 0 0 0 0 0 0 0 0 21.2264 21.2264 0 0 0 0 0 0 A0A9Q0YBZ7 A0A9Q0YBZ7_HOLLE Peptidase A2 domain-containing protein HOLleu_40984 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1.6 0.99822 -47.554 GMPHAEAA;NSPPTDHD 0 0 0 0 0 0 0 0 0 0 0 0 0 20.688 20.688 0 0 0 A0A9Q0YC04 A0A9Q0YC04_HOLLE Uncharacterized protein HOLleu_43321 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.2 1.0162 -22.715 DDFIWGGDQEFEDI 0 18.549 18.549 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YC31 A0A9Q0YC31_HOLLE Uncharacterized protein HOLleu_43097 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.8 0.95918 -0.068637 DSLYMKWPNLFKKVLQYADKQVNWK 20.8425 22.9292 22.9292 0 0 0 0 0 0 0 20.1977 20.1977 0 0 0 0 0 0 A0A9Q0YC57 A0A9Q0YC57_HOLLE Uncharacterized protein HOLleu_43116 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) deoxyribonucleotide biosynthetic process [GO:0009263] cytosol [GO:0005829] "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" 1 4.7 0.96783 -0.17167 FGAKRRRCVKRRRPKKTPKKKKKPI 21.3596 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YC82 A0A9Q0YC82_HOLLE N-lysine methyltransferase KMT5A-A HOLleu_39663 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] methyltransferase activity [GO:0008168] 1 0.6 1.0117 -23.777 SRLLLPPP 0 0 0 0 0 0 0 18.5088 18.5088 0 0 0 0 0 0 0 0 0 A0A9Q0YC85 A0A9Q0YC85_HOLLE C-type lectin domain-containing protein HOLleu_41960 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 3 1.0117 -23.777 DRWQDAPC 0 0 0 0 0 0 0 19.9962 19.9962 0 0 0 0 18.2822 18.2822 0 0 0 A0A9Q0YC97 A0A9Q0YC97_HOLLE RING-type domain-containing protein HOLleu_43028 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell cycle [GO:0007049]; negative regulation of apoptotic process [GO:0043066]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] endosome [GO:0005768] metal ion binding [GO:0046872]; p53 binding [GO:0002039]; ubiquitin protein ligase activity [GO:0061630] 1 2.3 0.97436 -0.068637 CICMPCGS 0 0 0 20.929 0 0 0 0 0 0 0 0 0 0 0 17.5541 0 0 A0A9Q0YCA3 A0A9Q0YCA3_HOLLE Low-density lipoprotein receptor-related protein 2 HOLleu_41857 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) receptor-mediated endocytosis [GO:0006898] apical plasma membrane [GO:0016324]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; hormone binding [GO:0042562] 5 1.6 1.0177 -17.081 CDIDDDCGDMSDEN;CENQECGSD;HWECDGHKDCSDFSDEHSDCAP;QCSSGHCISSSYQCDG;WQCDSWNDC 18.1262 23.4397 23.4397 15.6514 0 0 0 0 0 19.1509 18.3373 18.3373 22.6267 0 0 0 0 0 A0A9Q0YCH5 A0A9Q0YCH5_HOLLE Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein HOLleu_41996 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.8 1.0184 -23.777 YWHWTSSN 0 0 0 0 0 0 18.5043 18.239 18.239 0 0 0 0 0 0 0 0 0 A0A9Q0YCJ2 A0A9Q0YCJ2_HOLLE Uncharacterized protein HOLleu_42719 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.5 1.0231 -23.723 QHAARECQE 0 0 0 0 0 0 0 0 0 19.5503 0 0 0 0 0 0 0 0 A0A9Q0YCN6 A0A9Q0YCN6_HOLLE Ribose-phosphate pyrophosphokinase 4 HOLleu_39748 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189] magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749] 1 2.4 1.0196 -23.723 SSGSDPPFM 0 0 0 0 0 0 21.3341 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YCT8 A0A9Q0YCT8_HOLLE Uncharacterized protein HOLleu_44135 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.5 1.0113 -11.621 SSHLQDQLSRDHFVDCLE 0 0 0 0 0 0 0 18.7196 18.7196 0 0 0 0 0 0 0 0 0 A0A9Q0YCV0 A0A9Q0YCV0_HOLLE C2H2-type domain-containing protein HOLleu_44835 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0143 -2.6427 YPDMMLCFG 0 22.2065 22.2065 0 0 0 0 0 0 23.0468 22.2693 22.2693 0 0 0 0 0 0 A0A9Q0YCV4 A0A9Q0YCV4_HOLLE Proton channel OtopLc HOLleu_40084 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] proton channel activity [GO:0015252] 1 1.4 0.96199 -0.068637 GGYDPGYG 24.8327 24.6805 24.6805 0 0 0 0 0 0 0 0 0 0 19.5952 19.5952 0 0 0 A0A9Q0YCY1 A0A9Q0YCY1_HOLLE Uncharacterized protein HOLleu_40139 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 0.8 1.0111 -2.2424 PGAGGGGG;YGMGGGGG 0 0 0 0 18.9916 18.9916 22.3807 0 0 0 19.7576 19.7576 0 0 0 0 0 0 A0A9Q0YCY7 A0A9Q0YCY7_HOLLE Replication factor C subunit 1 HOLleu_39941 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281]; DNA replication [GO:0006260] DNA replication factor C complex [GO:0005663]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA clamp unloader activity [GO:0061860] 1 1.1 1.0223 -5.5496 DTQEEEEEDDM 0 0 0 0 0 0 0 0 0 0 0 0 0 22.9848 22.9848 0 0 0 A0A9Q0YD07 A0A9Q0YD07_HOLLE Armadillo repeat-containing protein 4 HOLleu_41851 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.8 1.0121 -23.777 GEYDHSDD 0 19.6466 19.6466 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YD14 A0A9Q0YD14_HOLLE Solute carrier organic anion transporter family member 4A1 HOLleu_39997 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] 1 5.8 1.0197 -5.6907 QFEFFSPCHAGCSQHFEDNMCS 0 0 0 0 0 0 20.8673 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YD23 A0A9Q0YD23_HOLLE Protein kinase C-binding protein 1 HOLleu_40014 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] cytoplasm [GO:0005737]; nucleus [GO:0005634] kinase activity [GO:0016301]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] 1 0.5 0.96532 -0.068637 LKMKHKLK 0 0 0 0 0 0 22.346 0 0 0 0 0 0 19.343 19.343 18.5211 0 0 A0A9Q0YD34 A0A9Q0YD34_HOLLE Uncharacterized protein HOLleu_40255 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 1.0148 -2.6427 PMRGSFQSD 20.8355 0 0 0 16.6073 16.6073 0 0 0 20.0096 0 0 0 16.8905 16.8905 0 0 0 A0A9Q0YD48 A0A9Q0YD48_HOLLE Pseudouridine-metabolizing bifunctional protein C1861.05 HOLleu_40072 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphate-containing compound metabolic process [GO:0006796] "hydrolase activity, acting on glycosyl bonds [GO:0016798]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; pseudouridylate synthase activity [GO:0004730]" 1 1.1 0.96542 -0.068637 ECSGDGDM 0 21.538 21.538 0 0 0 0 0 0 17.8539 17.1648 17.1648 0 0 0 0 0 0 A0A9Q0YD50 A0A9Q0YD50_HOLLE Leucine-rich repeat-containing G-protein coupled receptor 4 HOLleu_41926 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] 1 0.9 0.99927 -4.979 HERGGNSSSS 21.4965 22.541 22.541 0 0 0 0 0 0 22.741 22.2466 22.2466 18.6131 18.9812 18.9812 0 0 0 A0A9Q0YD63 A0A9Q0YD63_HOLLE Transmembrane protease serine 9 HOLleu_41076 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] 1 1.4 1.0208 -21.924 QVCDNIVDCDDYSDE 0 0 0 0 0 0 0 19.5166 19.5166 0 0 0 0 0 0 0 0 0 A0A9Q0YD86 A0A9Q0YD86_HOLLE Sterile alpha motif domain-containing protein 3 HOLleu_42190 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 16.9 1.0203 -21.924 EEVLMKRAKFGRKGR 0 0 0 0 0 0 0 0 0 21.0878 0 0 0 0 0 0 0 0 A0A9Q0YDA9 A0A9Q0YDA9_HOLLE Uncharacterized protein HOLleu_42113 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.2 1.0148 -2.6427 LPKPITPIS 0 0 0 0 0 0 0 21.5239 21.5239 0 0 0 0 0 0 0 0 0 A0A9Q0YDB4 A0A9Q0YDB4_HOLLE Protein Wnt HOLleu_41233 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] 2 5.2 1.0113 -7.7234 SCGCDTSY;TSMDYDGCDSM 0 0 0 0 0 0 0 0 0 21.6048 21.0116 21.0116 0 0 0 0 0 0 A0A9Q0YDC5 A0A9Q0YDC5_HOLLE Lupus La protein-like HOLleu_41010 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) tRNA processing [GO:0008033] nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] 1 3.3 1.0163 -6.0779 AEKVETKEEDGGGD 22.9303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YDC7 A0A9Q0YDC7_HOLLE Uncharacterized protein HOLleu_44409 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.9 0.90645 -0.068637 MGAGLAVV 0 0 0 0 21.4645 21.4645 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YDE3 A0A9Q0YDE3_HOLLE Prolow-density lipoprotein receptor-related protein 1 HOLleu_41055 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) receptor-mediated endocytosis [GO:0006898] apical plasma membrane [GO:0016324]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; hormone binding [GO:0042562] 5 1.5 0.99711 -34.224 CDGDDDCGDGSD;MEAMDEADYD;NTCSDYETQCRED;PDCPKGEDEANCDEACDL;VCDGEQDCADNS 20.4974 0 0 0 0 0 22.9205 22.6517 22.6517 0 0 0 24.7915 0 0 0 0 0 A0A9Q0YDF0 A0A9Q0YDF0_HOLLE G-protein coupled receptors family 3 profile domain-containing protein HOLleu_40991 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 2 1.2 1.0041 -26.317 IPKLVIIHRI;PKLVIIHRI 0 20.8993 20.8993 17.6734 19.8516 19.8516 21.5016 20.6077 21.5555 23.2686 0 0 0 19.3756 19.3756 17.4401 0 18.0917 A0A9Q0YDF3 A0A9Q0YDF3_HOLLE Adhesion G-protein coupled receptor G6 HOLleu_39810 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 0.9 1.0146 -6.0118 TPKENKSISKNT 22.9445 0 0 0 18.6251 0 0 0 18.9634 21.656 21.2212 21.2212 19.4399 19.6715 19.6715 0 0 0 A0A9Q0YDH5 A0A9Q0YDH5_HOLLE Squalene synthase (SQS) (SS) (EC 2.5.1.21) HOLleu_39865 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholesterol biosynthetic process [GO:0006695]; ergosterol biosynthetic process [GO:0006696]; farnesyl diphosphate metabolic process [GO:0045338] endoplasmic reticulum membrane [GO:0005789] farnesyl-diphosphate farnesyltransferase activity [GO:0004310]; farnesyltranstransferase activity [GO:0004311]; squalene synthase activity [GO:0051996] 1 3.1 1.014 -2.6427 MADWDMYCH 0 0 0 0 0 0 0 0 0 21.4559 0 0 0 0 0 0 0 0 A0A9Q0YDL3 A0A9Q0YDL3_HOLLE IgGFc-binding protein N-terminal domain-containing protein HOLleu_43605 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 1.0209 -23.723 YCHHRCHGS 0 0 0 0 0 0 0 0 0 19.9158 19.7082 19.7082 0 0 0 0 0 0 A0A9Q0YDQ2 A0A9Q0YDQ2_HOLLE Uncharacterized protein HOLleu_40011 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 4 23.4 1.0204 -17.98 DCESEYENEYE;DCESEYENEYESESKSEYE;GSEYEYVYE;YESEYEYESDSEYEYES 21.2123 19.9188 19.9188 0 0 0 24.948 0 0 22.1979 22.4766 22.4766 17.7664 17.5369 17.5369 0 0 0 A0A9Q0YDQ3 A0A9Q0YDQ3_HOLLE Endonuclease HOLleu_44067 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 0.5 1.0131 -2.6427 HQTHFKLIR 0 0 0 0 0 0 0 0 0 21.823 0 0 0 0 0 0 0 0 A0A9Q0YDQ6 A0A9Q0YDQ6_HOLLE Mucin-5B HOLleu_40620 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.0088 -2.6427 TPTTVRTTT 0 23.5393 23.5393 0 20.9344 20.9344 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YDR3 A0A9Q0YDR3_HOLLE Uncharacterized protein HOLleu_41270 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 14.3 1.0204 -5.5496 CVANYCGGCFA 22.0504 23.0525 23.0525 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YDS2 A0A9Q0YDS2_HOLLE Uncharacterized protein HOLleu_41288 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.2 1.0069 -6.2493 CCTGDQCYSQAIC 0 23.4408 23.4408 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YDT3 A0A9Q0YDT3_HOLLE Secreted protein HOLleu_40566 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 12.2 1.0141 -6.0118 TPQCKLTLKGNN 0 24.9212 24.9212 0 0 0 0 0 0 0 0 0 19.7611 19.9645 19.9645 0 0 0 A0A9Q0YDT5 A0A9Q0YDT5_HOLLE Enteropeptidase HOLleu_40680 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] 2 1.7 1.0066 -6.1466 GEEGGMVECSDEMP;GWGDTSEG 23.581 21.5305 21.5305 0 0 0 0 0 0 23.8322 0 0 0 0 0 0 0 0 A0A9Q0YDU1 A0A9Q0YDU1_HOLLE Frizzled-5 HOLleu_41333 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070]; non-canonical Wnt signaling pathway [GO:0035567] plasma membrane [GO:0005886] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] 1 1.8 0.99929 -4.979 TTPETCPCSC 0 25.2677 25.2677 0 0 0 0 0 0 0 24.0406 24.0406 0 0 0 0 0 0 A0A9Q0YDU6 A0A9Q0YDU6_HOLLE Epoxide hydrolase (EC 3.3.2.9) HOLleu_40702 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) aromatic compound catabolic process [GO:0019439]; epoxide metabolic process [GO:0097176] endoplasmic reticulum membrane [GO:0005789] cis-stilbene-oxide hydrolase activity [GO:0033961]; epoxide hydrolase activity [GO:0004301] 1 1.7 0.87541 -0.068637 LPKLMAED 0 0 0 19.7636 20.9007 20.9007 0 21.2166 21.2166 0 0 0 0 0 0 18.6358 19.6945 19.6945 A0A9Q0YDV0 A0A9Q0YDV0_HOLLE Uncharacterized protein HOLleu_43389 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 27 0.9957 -0.31124 DIKKLLKLSFSKLLLVYLVHFLSI 18.6936 0 0 0 0 0 0 0 0 22.6565 21.8003 21.8003 0 0 0 0 0 0 A0A9Q0YDZ5 A0A9Q0YDZ5_HOLLE Uncharacterized protein HOLleu_41437 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 23.8 1.0162 -5.7538 EDDDDLDLSPVMMGE 0 0 0 0 0 0 0 22.9068 22.9068 0 0 0 0 0 0 0 0 0 A0A9Q0YE01 A0A9Q0YE01_HOLLE G-protein coupled receptors family 1 profile domain-containing protein HOLleu_40711 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528] 4 3.1 0.99676 -34.605 ENCEDYECP;GFWNCQDYSDEE;GMEVQGGH;LNLWIVGL 26.2741 0 0 19.8717 20.0159 19.8296 20.6514 0 0 25.0317 0 0 20.4803 18.1122 18.1122 19.3389 0 19.4044 A0A9Q0YE19 A0A9Q0YE19_HOLLE Uncharacterized protein HOLleu_40258 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 4.3 1.0193 -23.742 ETYDDVASDNNAFDW;SDNNAFDWQESYD 0 0 0 0 0 0 0 0 0 0 0 0 0 20.6215 20.6215 0 0 0 A0A9Q0YE68 A0A9Q0YE68_HOLLE Solute carrier organic anion transporter family member HOLleu_40370 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] 1 1.3 1.0115 -2.6427 QCNMNCNCQ 0 0 0 0 0 0 0 0 0 21.5186 0 0 0 0 0 0 0 0 A0A9Q0YEE5 A0A9Q0YEE5_HOLLE Mesenchyme-specific cell surface glycoprotein HOLleu_38488 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 0.94462 -0.068637 LLTTLTLL 0 0 0 0 22.4589 22.4589 0 0 0 0 0 0 0 0 0 0 22.0541 22.0541 A0A9Q0YEE9 A0A9Q0YEE9_HOLLE Vacuolar protein sorting-associated protein 13B HOLleu_40563 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 0.6 1.0108 -7.7234 IKPITVLASVH;NHDGSMTW 0 23.8751 23.8751 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YEG9 A0A9Q0YEG9_HOLLE Methyltransferase-like protein 15 HOLleu_38522 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) rRNA base methylation [GO:0070475] cytoplasm [GO:0005737] rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424] 2 4.8 1.0083 -6.9147 FTDLDKLLK;IKPYLKKGGKL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 22.6835 22.6835 A0A9Q0YEJ2 A0A9Q0YEJ2_HOLLE Transmembrane protease serine 3 HOLleu_39885 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] 1 3.3 1.0118 -11.621 SFDDEENCECPDDYFTCN 0 0 0 0 0 0 17.0999 17.5915 17.5915 0 0 0 0 0 0 0 0 0 A0A9Q0YEJ4 A0A9Q0YEJ4_HOLLE Multiple epidermal growth factor-like domains protein 6 HOLleu_38579 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] calcium ion binding [GO:0005509]; scavenger receptor activity [GO:0005044] 1 0.9 1.0179 -21.924 ECRDGYYGHNCQYTC 0 0 0 0 0 0 21.1641 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YEK9 A0A9Q0YEK9_HOLLE BRCT domain-containing protein HOLleu_43290 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 1.0247 -23.631 FYLTGDEMFFE 0 0 0 0 0 0 0 0 0 22.5662 0 0 0 0 0 0 0 0 A0A9Q0YEL4 A0A9Q0YEL4_HOLLE Activin-binding protein HOLleu_38622 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; receptor clustering [GO:0043113] plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509]; laminin binding [GO:0043236] 3 1.3 0.99747 -31.969 DCGQDPCDNHK;DMECPEEMD;MGENMEGC 25.4206 23.9453 23.9453 0 0 0 0 0 0 23.2154 19.9296 19.9296 21.9811 19.8573 19.8573 0 0 0 A0A9Q0YEM6 A0A9Q0YEM6_HOLLE Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein HOLleu_39976 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.2 1.009 -2.6427 MCTECEEGY 20.0829 23.8742 23.8742 0 0 0 0 0 0 22.6864 22.9078 22.9078 18.4806 19.0624 19.0624 0 0 0 A0A9Q0YEN4 A0A9Q0YEN4_HOLLE Cadherin EGF LAG seven-pass G-type receptor 1 HOLleu_40760 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1.3 1.0169 -5.5496 DACLFYGDCCY 0 0 0 0 0 0 0 0 0 0 0 0 22.938 0 0 0 0 0 A0A9Q0YEP1 A0A9Q0YEP1_HOLLE VWFC domain-containing protein HOLleu_41785 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.4 1.0227 -23.631 QDECSRCFCNN 0 0 0 0 0 0 0 20.8719 20.8719 0 0 0 0 0 0 0 0 0 A0A9Q0YEP3 A0A9Q0YEP3_HOLLE TOG domain-containing protein HOLleu_38689 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cilium [GO:0005929] 1 2.1 1.013 -11.395 NILRATVFLINKLLKDKVI 0 21.9144 21.9144 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YEP5 A0A9Q0YEP5_HOLLE NACHT domain-containing protein HOLleu_40027 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 1.0022 -4.979 GRDSGGSASS 0 23.3657 23.3657 0 0 0 23.8833 0 0 0 23.6581 23.6581 0 21.6413 21.6413 0 0 0 A0A9Q0YET7 A0A9Q0YET7_HOLLE Tenascin-X HOLleu_40141 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 12 1 0.99506 -109.97 CNNRGICNDTIDPPTCTGC;CQDLCSGYGECSGGSCDCVNE;GDGNDKGG;GMGAGHGG;HGTCNSATLECLCD;HTRLIIQAKFVYC;PVCIDCDEGWM;QAGKGGGV;SCVCDEGYEG;SPESSNCTCDPCW;SSCDQDST;WTQESGCFECSGNWTGSDCSS 25.0189 23.2424 23.2424 0 0 0 21.9927 22.8924 22.8924 22.4431 23.4686 23.4686 23.6267 0 0 0 0 0 A0A9Q0YEU2 A0A9Q0YEU2_HOLLE IgGFc-binding protein N-terminal domain-containing protein HOLleu_38630 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.1 1.028 -23.631 THCQRSRKEKA 20.7029 22.9631 22.9631 0 16.6287 16.6287 0 18.1849 18.1849 20.3226 0 0 18.5874 0 0 0 0 16.492 A0A9Q0YEU6 A0A9Q0YEU6_HOLLE CUB and sushi domain-containing protein 1 HOLleu_40160 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] 3 1.4 1.0092 -15.316 CEDDTCQNGG;CNYEWYCDDGSDERDCDG;PGYPEGEDYEN 0 25.3885 25.3885 0 0 0 0 0 0 23.5466 22.9098 22.9098 0 0 0 0 0 0 A0A9Q0YF31 A0A9Q0YF31_HOLLE NPC intracellular cholesterol transporter 1 HOLleu_40331 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; intestinal cholesterol absorption [GO:0030299] plasma membrane [GO:0005886] cholesterol binding [GO:0015485] 2 1.3 0.99857 -46.438 IPKLLVSHI;QDGYCMTYGHCGTD 0 0 0 0 0 0 0 0 0 0 20.6829 20.6829 0 0 0 0 0 0 A0A9Q0YF36 A0A9Q0YF36_HOLLE U11/U12 small nuclear ribonucleoprotein 25 kDa protein HOLleu_39732 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA splicing, via spliceosome [GO:0000398]" U12-type spliceosomal complex [GO:0005689] DNA binding [GO:0003677] 1 3.4 1.0128 -6.0118 LPPSRKIPLKIP 0 0 0 0 0 0 0 0 0 0 24.9076 24.9076 0 0 0 0 0 0 A0A9Q0YF48 A0A9Q0YF48_HOLLE Solute carrier organic anion transporter family member HOLleu_40369 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] 1 1.5 1.0252 -23.675 NLDCSCSNDF 0 0 0 0 0 0 0 0 0 19.0763 18.8116 18.8116 0 0 0 0 0 0 A0A9Q0YF52 A0A9Q0YF52_HOLLE Uncharacterized protein HOLleu_38434 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.1 1.0252 -23.675 VDDDDDDDDE 0 0 0 0 0 0 0 0 0 16.7102 0 0 0 0 0 0 0 0 A0A9Q0YF90 A0A9Q0YF90_HOLLE Rho guanine nucleotide exchange factor 26 HOLleu_38543 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) guanyl-nucleotide exchange factor activity [GO:0005085] 2 1.9 1.0278 -23.473 GEGGTDMNHDNDSDSN;HDYSEFDDDDDYF 20.8316 21.5432 21.5432 0 0 0 0 0 0 0 19.6853 19.6853 0 0 0 0 0 0 A0A9Q0YFC3 A0A9Q0YFC3_HOLLE Uncharacterized protein HOLleu_40545 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.8 1.0272 -23.442 LLDLLKVRRHPL 0 0 0 17.4823 0 0 0 0 0 0 20.6109 20.6109 0 0 0 0 0 0 A0A9Q0YFC8 A0A9Q0YFC8_HOLLE Uncharacterized protein HOLleu_44888 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.1 0.95349 -0.17167 KESKEIYYVFREHEKIRSRLWRLNR 0 19.8655 19.8655 21.0834 0 0 0 21.6467 21.6467 22.6401 22.4364 22.4364 22.23 20.0685 20.0685 19.0935 0 18.6942 A0A9Q0YFG4 A0A9Q0YFG4_HOLLE SCO-spondin HOLleu_40639 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 2 2.6 1.0056 -9.2583 NCTNATCGENEEYVAC;NDLYRLNYLKKLSRLKSQLRV 19.8347 21.4999 21.4999 0 0 0 0 0 0 24.2936 23.6563 23.6563 0 0 0 0 0 0 A0A9Q0YFH2 A0A9Q0YFH2_HOLLE Condensin complex subunit 1 HOLleu_38720 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076] "condensed chromosome, centromeric region [GO:0000779]; nucleus [GO:0005634]" histone binding [GO:0042393] 2 1.5 1.0163 -16.819 DDGDDGDD;QQRGKEDEEGEEDDNDD 0 19.2724 19.2724 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YFH6 A0A9Q0YFH6_HOLLE Uncharacterized protein HOLleu_39084 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 17 1.0187 -23.723 MGWMDGWMD 0 16.8269 16.8269 0 16.8302 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YFI7 A0A9Q0YFI7_HOLLE Caveolin HOLleu_40242 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) caveola assembly [GO:0070836] caveola [GO:0005901]; Golgi membrane [GO:0000139] molecular adaptor activity [GO:0060090] 1 5.4 1.0174 -2.6427 PRMVGTLIG 0 0 0 0 0 0 0 0 0 0 0 0 22.0283 0 0 0 0 0 A0A9Q0YFJ1 A0A9Q0YFJ1_HOLLE Uncharacterized protein HOLleu_40259 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 1.6 1.0157 -22.727 WKEEEDEEYDDDEEDK;YDYIWKEEEDEEYDDD 0 0 0 0 0 0 0 22.9508 22.9508 0 0 0 0 0 0 0 0 0 A0A9Q0YFJ5 A0A9Q0YFJ5_HOLLE Uncharacterized protein HOLleu_44700 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 20 1.0295 -23.631 NLYKCHMDYFT 20.9902 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YFK9 A0A9Q0YFK9_HOLLE Adhesion G protein-coupled receptor L3 HOLleu_40759 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1.6 1.0248 -23.027 TADSSGESCTYTH 0 0 0 0 0 0 0 0 0 18.8505 0 0 0 0 0 0 0 0 A0A9Q0YFL4 A0A9Q0YFL4_HOLLE Hyalin HOLleu_40778 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] 2 1.2 1.0041 -8.7206 ETNENCTDTCGPSD;GRDYCGDQD 0 0 0 20.9806 0 0 0 22.8483 22.8483 23.4324 0 0 0 0 0 18.0642 0 0 A0A9Q0YFQ9 A0A9Q0YFQ9_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_39126 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] kinase activity [GO:0016301] 1 0.9 1.026 -23.675 NGGECMDSCD 0 0 0 0 0 0 0 18.4226 18.4226 0 0 0 0 0 0 0 0 0 A0A9Q0YG11 A0A9Q0YG11_HOLLE NACHT domain-containing protein HOLleu_40378 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 1.029 -23.442 IMKQLENIIMED 21.1104 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YG15 A0A9Q0YG15_HOLLE CUB domain-containing protein HOLleu_44279 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.4 1.0256 -23.631 NICDFYWDCEE 0 0 0 0 0 0 0 0 0 20.1502 0 0 0 0 0 0 0 0 A0A9Q0YG33 A0A9Q0YG33_HOLLE Uncharacterized protein HOLleu_39365 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "negative regulation of telomere maintenance via recombination [GO:0032208]; negative regulation of telomeric D-loop disassembly [GO:1905839]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance via telomerase [GO:0032210]; telomeric D-loop disassembly [GO:0061820]; telomeric loop formation [GO:0031627]" shelterin complex [GO:0070187] double-stranded telomeric DNA binding [GO:0003691]; G-rich strand telomeric DNA binding [GO:0098505]; telomerase activity [GO:0003720] 1 1.6 1.0214 -5.5496 DDCSEYHSAEE 0 0 0 0 0 0 0 0 0 0 21.5344 21.5344 0 0 0 0 0 0 A0A9Q0YG57 A0A9Q0YG57_HOLLE Apple domain-containing protein HOLleu_41609 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.3 1.0182 -2.6427 VCYYCCNTD 23.5544 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YG61 A0A9Q0YG61_HOLLE Uncharacterized protein HOLleu_40492 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3 1.0216 -23.027 LNKLPEEQSDKNG 20.6528 20.9383 20.9383 17.2975 17.7612 17.7612 19.1759 0 0 20.6693 0 0 18.464 18.777 18.777 0 0 17.235 A0A9Q0YG69 A0A9Q0YG69_HOLLE Zinc finger CW-type PWWP domain protein 1 HOLleu_38580 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] 1 1.7 0.99486 -4.7869 ESDPDTGCFMEHEGVDTE 0 0 0 0 0 0 0 21.4492 21.4492 19.7605 0 0 18.0795 0 0 0 0 0 A0A9Q0YG70 A0A9Q0YG70_HOLLE Epidermal retinol dehydrogenase 2 HOLleu_40511 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lipid droplet [GO:0005811] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" 1 7.5 0.91374 -0.068637 AMKNCMDA 0 0 0 0 0 0 0 0 0 0 21.1008 21.1008 0 0 0 0 0 0 A0A9Q0YG99 A0A9Q0YG99_HOLLE Tripartite motif-containing protein 3 HOLleu_39606 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 3.3 0.86842 -0.068637 TFCCQCVS 0 25.2482 25.2482 0 0 0 0 0 0 25.8136 0 0 0 0 0 0 0 0 A0A9Q0YGC8 A0A9Q0YGC8_HOLLE Arylsulfatase B HOLleu_39564 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sulfuric ester hydrolase activity [GO:0008484] 1 1.5 0.87417 -0.068637 GMIACMDE 0 0 0 0 0 0 0 0 0 0 26.3969 26.3969 0 0 0 0 0 0 A0A9Q0YGD1 A0A9Q0YGD1_HOLLE Suppressor of cytokine signaling 7 HOLleu_41334 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] phosphatidylinositol 3-kinase complex [GO:0005942] 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] 1 1.6 1.0143 -6.0118 DFGWYWGPMSWD 0 0 0 0 0 0 0 0 0 22.0307 0 0 0 0 0 0 0 0 A0A9Q0YGD3 A0A9Q0YGD3_HOLLE Mucin-5B HOLleu_40628 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 1 0.9 0.96144 -0.17167 NNTDGLCGWCGLNETNCQERGDCCE 0 0 0 0 0 0 21.7763 21.6963 21.6963 0 0 0 0 0 0 0 0 0 A0A9Q0YGK1 A0A9Q0YGK1_HOLLE Reverse transcriptase domain-containing protein HOLleu_40818 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.8 1 -4.979 PKIHKLETLI 0 0 0 0 0 0 0 0 0 0 21.6356 21.6356 0 0 0 0 0 0 A0A9Q0YGL9 A0A9Q0YGL9_HOLLE MAGUK p55 subfamily member 7 HOLleu_41553 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] 1 1.3 1.0087 -23.777 GWCGAHPD 0 0 0 0 0 0 0 0 0 23.0496 0 0 0 0 0 0 0 0 A0A9Q0YGM2 A0A9Q0YGM2_HOLLE Uncharacterized protein HOLleu_41949 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5 0 -0.068637 KDDNNYDC 0 25.2772 25.2772 0 0 0 19.3757 19.1615 19.1615 20.835 20.3777 20.3777 0 0 0 0 0 0 A0A9Q0YGM5 A0A9Q0YGM5_HOLLE Glutathione hydrolase 1 proenzyme HOLleu_40874 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutathione catabolic process [GO:0006751] plasma membrane [GO:0005886] acyltransferase activity [GO:0016746]; glutathione hydrolase activity [GO:0036374] 2 4.3 1.0106 -10.202 ENGGSMSSFDFDMYEAE;TQEGASTSTM 0 22.6352 22.6352 0 0 0 23.8223 0 0 21.6727 20.8173 20.8173 0 22.6035 22.6035 0 0 0 A0A9Q0YGT3 A0A9Q0YGT3_HOLLE Sarcalumenin HOLleu_43579 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] GTP binding [GO:0005525] 1 2.4 1.0125 -6.0118 RAITVRIHALLL 26.7184 0 0 25.2746 0 0 24.3649 23.2534 23.2534 26.2068 28.3672 28.3672 25.418 22.6636 23.1972 24.8253 0 0 A0A9Q0YGV8 A0A9Q0YGV8_HOLLE NACHT and WD repeat domain-containing protein 2 HOLleu_37269 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.9 1.0158 -6.0779 NGICPDECEEHEQY 0 17.6554 17.6554 0 0 0 22.1345 21.0177 21.0177 18.1881 17.2363 17.2363 0 15.4931 15.4931 0 0 0 A0A9Q0YGZ9 A0A9Q0YGZ9_HOLLE Reverse transcriptase domain-containing protein HOLleu_37335 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 1.0207 -23.027 VGVDDSQCDYYDD 18.9541 19.7335 19.7335 0 0 0 0 0 0 20.266 21.0313 21.0313 17.7592 15.5853 15.5853 0 0 0 A0A9Q0YH00 A0A9Q0YH00_HOLLE TNFR-Cys domain-containing protein HOLleu_39202 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 9.9 0.99786 -0.31124 YKIPFFVVLVLLVLVVIVLGGIIW 0 0 0 0 0 0 0 0 0 0 0 0 22.4585 0 0 0 0 0 A0A9Q0YH11 A0A9Q0YH11_HOLLE Transmembrane protease serine 9 HOLleu_41892 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] 2 1.9 1.006 -23.845 FVGASSSG;QNTGDAFQ 0 18.6284 18.6284 0 0 0 0 25.5814 25.5814 0 0 0 0 0 0 0 0 0 A0A9Q0YH40 A0A9Q0YH40_HOLLE Ankyrin-2 HOLleu_37418 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] 1 0.6 1.0022 -4.979 LRLVVPPKRA 0 23.1675 23.1675 22.8275 0 0 23.1232 22.791 22.791 0 0 0 0 0 0 21.6498 21.7692 22.578 A0A9Q0YH59 A0A9Q0YH59_HOLLE Glutathione S-transferase HOLleu_37463 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutathione metabolic process [GO:0006749] glutathione transferase activity [GO:0004364] 1 3.5 1.0099 -23.777 PKVIALLE 0 0 0 0 0 0 0 0 0 0 21.1805 21.1805 0 0 0 0 0 0 A0A9Q0YHA3 A0A9Q0YHA3_HOLLE Serine incorporator HOLleu_40093 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.5 1.0132 -6.0118 TSTACSCCCAAC 22.1302 23.5827 23.5827 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YHA7 A0A9Q0YHA7_HOLLE Hermansky-Pudlak syndrome 3 protein-like HOLleu_38610 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) organelle organization [GO:0006996] BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737] 1 2.8 1.0118 -5.5027 TGSPSSHTCNCLDCQA 0 24.2472 24.2472 0 15.9133 15.9133 19.4494 17.5773 0 0 0 0 18.7892 19.299 19.299 0 0 0 A0A9Q0YHB6 A0A9Q0YHB6_HOLLE Antistasin HOLleu_38632 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615]; membrane [GO:0016020] serine-type endopeptidase inhibitor activity [GO:0004867] 14 5.9 0.99506 -131.14 CHHDGDCA;CPPVMCMMFCDH;CQHECDSDMACPDDQKCC;DADGCDICDCEVCPPIMCT;DANGCSVCECLE;HTCQDPVTCPPVMCFM;KNDGDCSVNQKCCSNGC;MCMMFCEYG;MFCNMWCEHGYDRNHDGC;MGTCQHECDSDMACP;NMKCCSNG;PPVMCTMFCENGFQTDSNGCE;SDSDCNGAKKCCSNGCGHTCMD;VQDDNGCD 26.3823 26.7878 26.7878 0 0 0 23.8567 23.0974 23.0974 27.5674 26.4737 26.4737 19.6409 19.3823 19.3823 0 0 0 A0A9Q0YHD6 A0A9Q0YHD6_HOLLE RNA-directed DNA polymerase from mobile element jockey HOLleu_37589 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) RNA-directed DNA polymerase activity [GO:0003964] 1 4.9 1.0167 -22.715 FLCRLKASIPRKEL 0 0 0 0 0 0 0 0 0 21.2548 0 0 0 0 0 0 0 0 A0A9Q0YHH2 A0A9Q0YHH2_HOLLE Tripartite motif-containing protein 3 HOLleu_39608 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 3.7 1.0125 -16.819 RATYCEDYENSEDFYGD 0 19.7548 19.7548 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YHH4 A0A9Q0YHH4_HOLLE Pleckstrin-likey domain-containing family M member 3 HOLleu_38763 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) autophagy [GO:0006914] endosome [GO:0005768] metal ion binding [GO:0046872] 2 2.5 0.99821 -46.491 KKIGVGGG;TFWPFITKFTHRDV 0 17.7275 17.7275 0 0 0 0 19.1316 19.1316 0 0 0 0 0 0 0 0 0 A0A9Q0YHI0 A0A9Q0YHI0_HOLLE Fat-like cadherin-related tumor suppressor-like HOLleu_37675 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] 1 1 1.0231 -5.5496 VILFIGIIIMI 0 25.3362 25.3362 0 0 0 0 0 0 26.091 0 0 0 0 0 0 0 0 A0A9Q0YHK5 A0A9Q0YHK5_HOLLE Extracellular matrix protein FRAS1 HOLleu_37607 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154] collagen-containing extracellular matrix [GO:0062023]; membrane [GO:0016020] 1 0.5 1.0134 -11.621 NCNACNGPSPNDCVECME 19.6429 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YHM0 A0A9Q0YHM0_HOLLE Twitchin HOLleu_40358 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] 1 0.2 0.9564 -0.068637 KPTSDGGA 0 0 0 0 0 0 0 0 0 22.8525 22.5394 22.5394 0 0 0 0 0 0 A0A9Q0YHP1 A0A9Q0YHP1_HOLLE Protein unc-93-like A HOLleu_39958 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of muscle contraction [GO:0006937]; regulation of potassium ion transport [GO:0043266] plasma membrane [GO:0005886]; striated muscle dense body [GO:0055120] potassium channel regulator activity [GO:0015459] 1 3.7 1.0095 -5.2234 DFTCGAQDCSTETRDEN 23.1082 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YHP7 A0A9Q0YHP7_HOLLE Sulfotransferase HOLleu_37756 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.1 1.0183 -2.6427 RPCDEDMDD 0 0 0 0 0 0 0 0 0 22.8479 0 0 0 0 0 0 0 0 A0A9Q0YHQ7 A0A9Q0YHQ7_HOLLE Uncharacterized protein HOLleu_37213 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.4 0.97429 -0.068637 VRARPPRL 0 0 0 19.9818 0 0 21.1549 0 0 0 0 0 0 0 0 17.3168 0 18.3535 A0A9Q0YHS3 A0A9Q0YHS3_HOLLE Amiloride-sensitive sodium channel subunit gamma HOLleu_37811 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] ligand-gated sodium channel activity [GO:0015280] 1 1.9 1.0251 -23.631 WEELPDWWGDY 19.9357 18.2656 18.2656 0 0 0 0 0 0 17.0401 0 0 0 0 0 0 0 0 A0A9Q0YHU1 A0A9Q0YHU1_HOLLE ATP-binding cassette sub-family G member 2 HOLleu_37290 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] 1 1.2 0.9497 -0.068637 YWMMGFQA 24.561 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YHU4 A0A9Q0YHU4_HOLLE Angiopoietin-1 HOLleu_37850 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4.7 1.0022 -27.848 ATCDDSHGCDNSCNEEEGCV;DDSHGCDNS 21.3071 25.4341 25.4341 0 18.3438 0 19.0768 19.3829 19.3829 21.2012 0 0 19.2109 18.4988 18.4988 0 0 0 A0A9Q0YHW0 A0A9Q0YHW0_HOLLE Glucosidase 2 subunit beta HOLleu_40146 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) liver development [GO:0001889]; N-glycan processing [GO:0006491] glucosidase II complex [GO:0017177]; membrane [GO:0016020] 2 4.8 1.006 -24.379 NDDYCDCQQDGSDE;QQDGSDEP 0 20.7593 20.7593 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YI03 A0A9Q0YI03_HOLLE Protein slit HOLleu_37386 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.1 0.99925 -4.564 PSECSCTSNSDGNGIIDCS 19.4809 19.2916 19.2916 0 0 0 22.8268 22.7413 22.7413 20.7752 19.7459 19.7459 17.0988 16.8869 16.8869 19.2706 0 20.6173 A0A9Q0YI04 A0A9Q0YI04_HOLLE Protein RCC2 HOLleu_39024 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] small GTPase binding [GO:0031267] 1 1 1.0075 -23.777 CGGEFSMM 0 0 0 0 15.705 15.705 0 0 0 18.9924 18.7916 18.7916 18.6743 18.8007 18.8007 0 0 0 A0A9Q0YI13 A0A9Q0YI13_HOLLE Uncharacterized protein HOLleu_37403 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.4 0.95308 -0.068637 HIGCNEGN 0 0 0 0 0 0 21.2775 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YI33 A0A9Q0YI33_HOLLE Sulfotransferase HOLleu_39227 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 0.95294 -0.068637 RKLKLPPA 22.5634 24.468 24.468 20.9275 21.3095 21.3095 21.9326 21.4701 21.4701 24.1052 23.34 23.34 21.5818 21.4919 21.4919 20.4175 0 20.8517 A0A9Q0YI45 A0A9Q0YI45_HOLLE Anthrax toxin receptor 2 HOLleu_38007 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] signaling receptor activity [GO:0038023] 1 7 1.0164 -21.924 AATGETDGCCSCFST 0 0 0 0 0 0 0 0 0 18.5486 18.4425 18.4425 0 0 0 0 0 0 A0A9Q0YI75 A0A9Q0YI75_HOLLE Cyclin-dependent kinase 1 HOLleu_37551 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; phosphorylation [GO:0016310] nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] 1 3.2 0.99928 -4.979 IFAELVTKKP 0 0 0 0 0 0 0 0 0 0 0 0 0 20.7584 20.7584 0 0 0 A0A9Q0YI85 A0A9Q0YI85_HOLLE GRB2-associated and regulator of MAPK protein 2 HOLleu_40801 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 2.2 0.99929 -47.554 MGSSFDSG;SSSSGKSK 0 0 0 18.869 0 0 0 0 0 0 0 0 18.0517 0 0 0 0 0 A0A9Q0YI91 A0A9Q0YI91_HOLLE Reverse transcriptase domain-containing protein HOLleu_39169 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.8 1.027 -5.5496 ADDNRCNYDNN 0 21.7067 21.7067 0 0 0 0 0 0 24.3863 0 0 0 0 0 0 0 0 A0A9Q0YIA1 A0A9Q0YIA1_HOLLE Uncharacterized protein HOLleu_39187 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.7 0.94955 -0.068637 VVDVVGGT 0 0 0 0 0 0 0 0 0 0 0 0 21.3358 0 0 0 0 0 A0A9Q0YIB7 A0A9Q0YIB7_HOLLE Solute carrier organic anion transporter family member 1C1 HOLleu_40489 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347] 2 2.2 1.0048 -25.951 VGCFMCAG;VPGVMVRN 0 19.0373 19.0373 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YIC2 A0A9Q0YIC2_HOLLE histone acetyltransferase (EC 2.3.1.48) HOLleu_37639 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944] MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleosome [GO:0000786] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] 4 1.6 1.0123 -11.933 HSNSSSPH;KPKKPVLKPLD;TSDEDDDDDDDD;VRKAKDIEKKKK 23.7179 24.7989 24.7989 0 0 0 0 26.2486 26.2486 21.9174 0 0 18.2733 18.2885 18.2885 0 0 0 A0A9Q0YIH2 A0A9Q0YIH2_HOLLE Death domain-containing protein HOLleu_42122 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 5.1 1.0228 -23.631 HTYQENEKKLK 0 0 0 0 0 0 0 0 0 0 20.8044 20.8044 0 0 0 0 0 0 A0A9Q0YIL9 A0A9Q0YIL9_HOLLE E3 ubiquitin-protein ligase TRIM39 HOLleu_39610 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 2.9 1.0261 -23.723 LMEFYCETC 0 18.7696 18.7696 0 0 0 0 0 0 17.5576 16.9807 16.9807 0 0 0 0 0 0 A0A9Q0YIM0 A0A9Q0YIM0_HOLLE Uncharacterized protein HOLleu_38400 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.8 1.0104 -23.777 LLRHARQK 0 0 0 0 0 0 18.8136 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YIP7 A0A9Q0YIP7_HOLLE Uncharacterized protein HOLleu_39512 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2 0.90615 -0.068637 WDVSPGGT 19.1013 21.5203 21.5203 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YIQ0 A0A9Q0YIQ0_HOLLE Hyalin HOLleu_38457 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 2 0.8 1.0056 -24.457 SFFCLCESGFSGNTCAMMDPDP;TCTCTDSGGLSSGCS 21.1779 21.8357 21.8357 0 0 0 0 0 0 0 0 0 18.1738 0 0 0 0 0 A0A9Q0YIR6 A0A9Q0YIR6_HOLLE Structural maintenance of chromosomes flexible hinge domain-containing protein 1 HOLleu_40798 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chromosome organization [GO:0051276]; double-strand break repair [GO:0006302] chromosome [GO:0005694] ATP binding [GO:0005524] 2 1.5 1.0086 -5.4314 NIERTPRRRCSLPRFQSSDPDVL;PLKRLPQR 21.389 21.6851 21.6851 0 19.8227 0 0 19.7696 19.7696 0 0 0 19.9526 20.4635 20.4635 0 0 0 A0A9Q0YIT3 A0A9Q0YIT3_HOLLE DIS3-like exonuclease 2 (EC 3.1.13.-) HOLleu_38512 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "miRNA catabolic process [GO:0010587]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyuridylation-dependent mRNA catabolic process [GO:1990074]" cytosol [GO:0005829]; P-body [GO:0000932] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] 1 1.1 1.0213 -5.5496 SSEESSCSGDN 0 0 0 0 0 0 0 0 0 20.7095 0 0 0 0 0 0 0 0 A0A9Q0YIT9 A0A9Q0YIT9_HOLLE Cysteine-rich motor neuron 1 protein HOLleu_41165 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 0.99928 -4.979 VSCHEQECAA 20.4268 21.5342 21.5342 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YIU8 A0A9Q0YIU8_HOLLE RUN and FYVE domain-containing protein 2 HOLleu_37174 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 2.5 1.0302 -23.442 QHSLRLILHVLH 0 0 0 0 0 0 0 0 0 0 0 0 19.8322 0 0 0 0 0 A0A9Q0YIV2 A0A9Q0YIV2_HOLLE Kelch-like protein 20 HOLleu_40875 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.8 1.0119 -5.5027 GGADSESSYNTVECYD 0 22.7402 22.7402 0 15.0028 15.0028 0 0 0 22.281 22.5235 22.5235 0 0 0 0 0 0 A0A9Q0YIV5 A0A9Q0YIV5_HOLLE Histone H4 HOLleu_35749 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] 1 11.6 0.94895 -0.068637 MSGRGKGG 0 0 0 0 0 0 0 0 0 0 0 0 20.8753 0 0 0 0 0 A0A9Q0YIV7 A0A9Q0YIV7_HOLLE EGF-like domain-containing protein HOLleu_38058 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.2 1.0191 -23.723 SNPEDDCED 0 0 0 0 0 0 0 0 0 18.2599 0 0 0 0 0 0 0 0 A0A9Q0YIX8 A0A9Q0YIX8_HOLLE Atrial natriuretic peptide receptor 1 HOLleu_38609 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653] 1 1.4 1.02 -2.6427 IPLILYIAW 0 0 0 0 0 0 0 0 0 0 0 0 21.3473 0 0 0 0 0 A0A9Q0YJ07 A0A9Q0YJ07_HOLLE Low-density lipoprotein receptor-related protein 2 HOLleu_41318 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) receptor-mediated endocytosis [GO:0006898] apical plasma membrane [GO:0016324]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; hormone binding [GO:0042562] 7 2.5 0.99575 -65.955 CDFPECEEDQFE;CDFYDDCGYHDDENQFCG;CGYHDDENQFCGY;DCGDKSDE;FDDCGDKSDETDDRCSDCDH;GSDEVNCDRDEC;ILDFWHCDGENDCFD 22.3562 23.5925 23.5925 0 15.0153 15.0153 24.064 22.7119 22.7119 23.3119 24.0889 24.0917 0 16.9979 16.9979 0 0 0 A0A9Q0YJ36 A0A9Q0YJ36_HOLLE Doublecortin domain-containing protein 5 HOLleu_35824 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412] midbody [GO:0030496] microtubule binding [GO:0008017] 1 0.4 0.94578 -0.068637 GLGSHPFP 0 0 0 0 20.3394 20.3394 0 0 0 17.0628 0 0 0 0 0 18.2694 0 19.4401 A0A9Q0YJ54 A0A9Q0YJ54_HOLLE Phosphatidylserine synthase (EC 2.7.8.29) (Serine-exchange enzyme) HOLleu_35978 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphatidylserine biosynthetic process [GO:0006659] endoplasmic reticulum membrane [GO:0005789] L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245] 2 5.1 1.0037 -24.698 PLVMKLPP;RPYRKHKRKQLMEAKRER 0 0 0 0 0 0 0 0 0 0 0 0 18.8677 19.4229 19.4229 0 0 0 A0A9Q0YJ55 A0A9Q0YJ55_HOLLE Activated RNA polymerase II transcriptional coactivator p15 HOLleu_38398 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of transcription initiation by RNA polymerase II [GO:0060261] nucleus [GO:0005634] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713] 1 4.5 1.0204 -5.5496 TPQQWFQPGKI 22.724 0 0 0 0 0 0 0 0 0 0 0 19.8999 0 0 0 0 0 A0A9Q0YJ58 A0A9Q0YJ58_HOLLE Adenosine deaminase 2 HOLleu_35981 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103] extracellular space [GO:0005615] adenosine deaminase activity [GO:0004000] 1 3.3 1.029 -23.631 EREDFCDDSWI 0 0 0 0 0 0 0 0 0 0 0 0 0 20.7692 20.7692 0 0 0 A0A9Q0YJ74 A0A9Q0YJ74_HOLLE "NAD-dependent protein deacetylase sirtuin-3, mitochondrial" HOLleu_35957 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; transferase activity [GO:0016740] 1 1.5 0.9426 -0.068637 VVMAGAGI 0 0 0 22.1095 0 0 0 0 0 0 0 0 0 0 0 20.9181 21.1161 21.8861 A0A9Q0YJ81 A0A9Q0YJ81_HOLLE Histone-lysine N-methyltransferase SETD2 HOLleu_41519 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259]; regulation of DNA-templated transcription [GO:0006355] chromosome [GO:0005694]; nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975] 2 0.7 1.006 -24.438 ERSGDRYKRRRRWSE;RPISSKEAM 0 20.404 20.404 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YJB5 A0A9Q0YJB5_HOLLE Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) HOLleu_41585 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to thyroid hormone stimulus [GO:0097067]; positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coregulator activity [GO:0003712] 1 0.4 0.99445 -0.39854 TSDGDEDDDE 0 23.3158 23.3158 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YJB7 A0A9Q0YJB7_HOLLE Protein phosphatase 1 regulatory subunit 15B HOLleu_36069 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of phosphate metabolic process [GO:0045936]; negative regulation of protein modification process [GO:0031400]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; protein phosphatase type 1 complex [GO:0000164] protein phosphatase regulator activity [GO:0019888] 1 2.4 1.0031 -4.125 ADCDWDMLDESNDTNDTWDE 0 0 0 0 0 0 0 0 0 0 0 0 21.2291 22.3868 22.3868 0 0 0 A0A9Q0YJD5 A0A9Q0YJD5_HOLLE Peptidase inhibitor 16 HOLleu_36009 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] 1 7.1 1.0184 -5.6907 CEDKHYYCGANPGWPTRWCNDS 0 0 0 0 0 0 0 19.8128 19.8128 0 0 0 0 0 0 0 0 0 A0A9Q0YJE5 A0A9Q0YJE5_HOLLE Cytoskeleton-associated protein 5 HOLleu_36026 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) centrosome duplication [GO:0051298]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; microtubule polymerization [GO:0046785]; mitotic spindle organization [GO:0007052] centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule plus-end [GO:0035371]; spindle pole [GO:0000922] microtubule plus end polymerase [GO:0061863]; microtubule plus-end binding [GO:0051010] 2 1.3 1.019 -5.7055 KRPKTAPSKS;NIRKGVRKVMKLLMKL 0 23.9554 23.9554 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YJF9 A0A9Q0YJF9_HOLLE Chromodomain-helicase-DNA-binding protein 3 HOLleu_38565 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872] 4 3 0.99609 -51.442 FYCKFHGMSYWHC;LSDNSSDYSAKSDEEDEDEDFD;RAPKIPTPKL;YGGGSSEEDGYETDHQDYCEVCQ 0 0 0 0 0 0 0 0 0 25.3091 25.383 25.383 17.5792 0 0 0 0 0 A0A9Q0YJG8 A0A9Q0YJG8_HOLLE [histone H4]-N-methyl-L-lysine(20) N-methyltransferase (EC 2.1.1.362) HOLleu_36066 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; methylation [GO:0032259] nucleus [GO:0005634] histone H4K20 methyltransferase activity [GO:0042799]; nucleic acid binding [GO:0003676] 3 2 1.0052 -24.458 GEDFFGEGNCYCECE;GNCYCECE;PRVVIPKAIQ 0 24.3774 24.3774 0 0 0 0 0 0 21.5707 0 0 0 0 0 0 0 0 A0A9Q0YJH0 A0A9Q0YJH0_HOLLE Hexosyltransferase (EC 2.4.1.-) HOLleu_38584 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glycosaminoglycan biosynthetic process [GO:0006024]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] UDP-galactosyltransferase activity [GO:0035250] 1 4.7 1.0195 -17.224 FVIGTAKISDAEIKQL 0 0 0 0 0 0 0 0 0 20.4896 0 0 0 0 0 0 0 0 A0A9Q0YJL2 A0A9Q0YJL2_HOLLE Uncharacterized protein HOLleu_36159 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8 1.0016 -6.2493 FQSYEDDEDLESM 0 0 0 0 0 0 0 0 0 0 22.1948 22.1948 17.8215 17.9001 17.9001 0 0 0 A0A9Q0YJP6 A0A9Q0YJP6_HOLLE branched-chain-amino-acid transaminase (EC 2.6.1.42) HOLleu_36030 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) amino acid biosynthetic process [GO:0008652]; leucine biosynthetic process [GO:0009098]; valine biosynthetic process [GO:0009099] mitochondrion [GO:0005739] branched-chain-amino-acid transaminase activity [GO:0004084] 1 1.9 0.93902 -0.068637 MFGAGTAC 0 0 0 0 0 0 0 0 0 0 22.5827 22.5827 0 0 0 0 0 0 A0A9Q0YJQ1 A0A9Q0YJQ1_HOLLE Uncharacterized protein HOLleu_37625 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.2 1.009 -2.6427 KDDDEDEED 0 27.2151 27.2151 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YJQ4 A0A9Q0YJQ4_HOLLE Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) HOLleu_36050 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair [GO:0006302] membrane [GO:0016020]; nucleolus [GO:0005730] NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779] 1 2.3 1.0146 -6.0118 TKQIKLRYLVKV 0 0 0 0 0 0 0 0 0 27.8094 0 0 0 0 0 0 0 0 A0A9Q0YJQ5 A0A9Q0YJQ5_HOLLE Uncharacterized protein HOLleu_37518 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion involved in heart morphogenesis [GO:0061343]; DNA repair [GO:0006281]; larval heart development [GO:0007508] extracellular matrix [GO:0031012] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] 1 0.9 1.0216 -23.675 RIIETEDDCC 0 0 0 0 0 0 18.3069 18.6942 18.6942 0 0 0 0 0 0 0 0 0 A0A9Q0YJQ8 A0A9Q0YJQ8_HOLLE Netrin receptor UNC5 HOLleu_36421 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] 1 0.5 1.0261 -23.723 MYTWEDVDE 0 0 0 0 18.5948 0 0 19.6598 19.6598 0 0 0 0 0 0 0 0 0 A0A9Q0YJQ9 A0A9Q0YJQ9_HOLLE Condensin-2 complex subunit H2 (Non-SMC condensin II complex subunit H2) HOLleu_36071 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) meiotic chromosome condensation [GO:0010032]; mitotic sister chromatid separation [GO:0051306] condensin complex [GO:0000796]; nucleus [GO:0005634] chromatin binding [GO:0003682] 2 1.6 1.0121 -2.2424 GMMGGFDG;MGGFDGME 0 0 0 0 0 0 0 22.8373 22.8373 0 0 0 0 0 0 0 0 0 A0A9Q0YJT7 A0A9Q0YJT7_HOLLE DNA damage-regulated autophagy modulator protein 2 HOLleu_36496 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 1 3.1 1.0112 -23.777 MMCFGIGS 17.0732 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YJT8 A0A9Q0YJT8_HOLLE Potassium voltage-gated channel subfamily A member 2 HOLleu_36500 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] 1 1.7 1.0014 -4.979 DESVESNMDI 0 0 0 0 0 0 0 0 0 0 0 0 0 21.0328 21.0328 0 0 0 A0A9Q0YJW1 A0A9Q0YJW1_HOLLE Uncharacterized protein HOLleu_36539 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 0.96232 -0.068637 TLMAGPSG 0 22.5879 22.5879 0 0 0 0 0 0 0 0 0 15.1748 0 0 18.1327 0 17.041 A0A9Q0YJZ0 A0A9Q0YJZ0_HOLLE Tetraspanin HOLleu_41951 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of vascular endothelial growth factor signaling pathway [GO:1900746] membrane [GO:0016020] 1 5.5 1.0167 -22.715 EKCCVLIIVVLTII 0 0 0 0 0 0 0 0 0 20.9644 0 0 0 0 0 0 0 0 A0A9Q0YK01 A0A9Q0YK01_HOLLE Lysosomal amino acid transporter 1-like HOLleu_39251 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.8 1.0182 -23.723 YKIKNRRKV 0 0 0 0 17.132 17.132 0 0 0 0 0 0 0 0 0 0 16.0319 16.0319 A0A9Q0YK20 A0A9Q0YK20_HOLLE Uncharacterized protein HOLleu_38846 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 13.9 1.0169 -5.5496 CSCGYCGSNGI 0 0 0 0 0 0 20.9493 20.5148 20.5148 0 0 0 0 0 0 0 0 0 A0A9Q0YK36 A0A9Q0YK36_HOLLE "Rhodopsin, GQ-coupled" HOLleu_37833 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to light stimulus [GO:0071482]; phototransduction [GO:0007602] membrane [GO:0016020] G protein-coupled photoreceptor activity [GO:0008020] 1 1.9 1.0183 -23.723 YHTVRKGFK 18.3977 0 0 0 0 0 17.942 0 0 19.5561 19.3385 19.3385 19.0333 18.0856 18.0856 0 0 0 A0A9Q0YK47 A0A9Q0YK47_HOLLE SCY1-like protein 2 HOLleu_36420 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] 1 5 0.96552 -0.17167 KGLPKILSKLPKRVVLQRVLPCLCK 0 19.2344 19.2344 0 0 0 0 0 0 23.0945 22.4177 22.4177 20.4408 0 0 16.3377 0 0 A0A9Q0YK72 A0A9Q0YK72_HOLLE MFS-type transporter SLC18B1 HOLleu_39751 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 1 2.3 1.0007 -4.979 DMEGESDDEE 24.7421 20.8047 20.8047 0 0 0 0 0 0 0 25.2718 25.2718 0 0 0 0 0 0 A0A9Q0YK75 A0A9Q0YK75_HOLLE exodeoxyribonuclease III (EC 3.1.11.2) HOLleu_36700 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) base-excision repair [GO:0006284] nucleus [GO:0005634] DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; phosphoric diester hydrolase activity [GO:0008081] 1 4 0.84375 -0.068637 CTSSGCSV 24.5925 24.7723 24.7723 0 0 0 0 0 0 0 24.1866 24.1866 0 16.6243 16.6243 0 0 0 A0A9Q0YK80 A0A9Q0YK80_HOLLE Tenascin-R HOLleu_36494 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] ATP binding [GO:0005524]; transferase activity [GO:0016740] 1 3.2 1.0048 -6.2493 DGQGQFDVYCDMD 21.4516 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YKB0 A0A9Q0YKB0_HOLLE HORMA domain-containing protein 1 HOLleu_36766 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) meiotic recombination checkpoint signaling [GO:0051598]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694]; nucleus [GO:0005634] 1 1.5 1.0192 -2.6427 KPLIGVKPV 0 0 0 0 0 0 22.3803 22.5779 22.5779 24.1598 0 0 0 0 0 0 0 0 A0A9Q0YKB9 A0A9Q0YKB9_HOLLE Synaptonemal complex protein 3 HOLleu_36789 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] synaptonemal complex [GO:0000795] 1 3.9 1.0183 -2.6427 YEEDEDDEL 19.9334 21.5474 21.5474 0 0 0 0 0 0 19.0196 17.0212 17.0212 0 0 0 0 0 0 A0A9Q0YKC2 A0A9Q0YKC2_HOLLE Core-binding (CB) domain-containing protein HOLleu_36791 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677] 2 2.6 1.0044 -26.419 KRPPRRRLA;SHSQPSGG 0 0 0 0 0 0 25.5588 0 0 0 0 0 19.151 0 0 0 0 0 A0A9Q0YKD5 A0A9Q0YKD5_HOLLE C2H2-type domain-containing protein HOLleu_38031 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.4 1.0146 -5.7538 NQDGGPEEEGDADGT 0 0 0 0 0 0 0 22.6706 22.6706 0 0 0 0 0 0 0 0 0 A0A9Q0YKF2 A0A9Q0YKF2_HOLLE Uncharacterized protein HOLleu_38066 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.8 1.011 -2.5328 VDGDDDHDDDDADSCSKDDDTY 0 0 0 0 0 0 24.6561 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YKF4 A0A9Q0YKF4_HOLLE Nuclear receptor coactivator 4 HOLleu_38103 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular iron ion homeostasis [GO:0006879]; response to hormone [GO:0009725] transcription coactivator activity [GO:0003713] 1 2.7 1.0173 -16.819 CQANEMCQSFSECVCDE 0 0 0 0 0 0 0 0 0 0 0 0 0 20.6724 20.6724 0 0 0 A0A9Q0YKF7 A0A9Q0YKF7_HOLLE Tetraspanin HOLleu_36694 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5.1 1.0007 -4.979 VVLLLLLAEV 24.3623 21.7948 21.7948 0 0 0 0 0 0 21.6829 20.8951 20.8951 19.3569 18.2123 0 0 0 0 A0A9Q0YKF8 A0A9Q0YKF8_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_39125 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] kinase activity [GO:0016301] 2 1.9 1.0166 -6.0118 CSCGCGWRGSDC;GGGAPDAA 0 22.977 22.977 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YKH4 A0A9Q0YKH4_HOLLE L-rhamnose-binding lectin ELEL-1 HOLleu_39183 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate binding [GO:0030246] 1 3 1.0238 -23.675 ILDKPTKGIM 0 0 0 0 0 0 0 20.2478 20.2478 0 0 0 0 0 0 0 0 0 A0A9Q0YKK3 A0A9Q0YKK3_HOLLE Basement membrane-specific heparan sulfate proteoglycan core protein HOLleu_36811 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] axon [GO:0030424]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; cell-cell adhesion mediator activity [GO:0098632] 1 1.3 1.014 -6.0779 MFSTESYRTTKEPD 0 0 0 0 0 0 0 21.9075 21.9075 0 0 0 0 0 0 0 0 0 A0A9Q0YKM2 A0A9Q0YKM2_HOLLE YTH domain-containing family protein 2 HOLleu_40095 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA destabilization [GO:0061157] cytoplasm [GO:0005737] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247] 1 2.3 1.0083 -6.0779 NSGNSGGYSSSSSS 0 25.2286 25.2286 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YKP8 A0A9Q0YKP8_HOLLE Protein lin-54-like HOLleu_37240 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] 2 1.9 1.0007 -5.0477 EFCHECNC;HECNCCNCLN 0 0 0 0 0 0 0 0 0 24.4661 0 0 0 0 0 0 0 0 A0A9Q0YKQ3 A0A9Q0YKQ3_HOLLE Uncharacterized protein HOLleu_34252 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4 1.0055 -6.2493 MQQERCMCNEGLS 0 23.6279 23.6279 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YKS3 A0A9Q0YKS3_HOLLE Uncharacterized protein HOLleu_35550 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 0.90997 -0.068637 RVAHGSTT 0 23.0153 23.0153 18.9762 20.1448 20.1448 0 0 0 22.0608 21.8817 21.8817 0 0 0 17.6786 0 18.5794 A0A9Q0YKU6 A0A9Q0YKU6_HOLLE Uncharacterized protein HOLleu_37037 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.4 1.0047 -23.777 MGGCGDFS 0 20.3073 20.3073 0 0 0 0 0 0 19.5758 18.8235 18.8235 0 0 0 0 0 0 A0A9Q0YKV7 A0A9Q0YKV7_HOLLE CCHC-type domain-containing protein HOLleu_37375 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 2 3.9 1.0202 -1.4337 DSYLKRFER;VDNSMFTG 0 0 0 0 0 0 22.9657 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YKV8 A0A9Q0YKV8_HOLLE Cadherin-23 HOLleu_38280 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] 4 1.2 1.003 -27.649 CQDQSDESQQECFPPCASD;EADGSEYSCVCQSGFT;EFMCEDPQPCD;TDQNCQTPDPCFSSPCLNGATCIS 0 24.6466 24.6466 0 0 0 22.4801 22.4823 22.4823 0 19.586 19.586 0 0 0 0 0 0 A0A9Q0YL00 A0A9Q0YL00_HOLLE Kin of IRRE-like protein 1 HOLleu_34411 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.9 0.99858 -4.979 ILVVFIIFRI 0 0 0 0 0 0 0 0 0 21.907 0 0 0 0 0 0 0 0 A0A9Q0YL03 A0A9Q0YL03_HOLLE Uncharacterized protein HOLleu_34409 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 7.7 1.0049 -6.2493 PKIIKETNFWSFT 0 0 0 0 0 0 0 0 0 22.6478 0 0 0 0 0 0 0 0 A0A9Q0YL27 A0A9Q0YL27_HOLLE NLR family CARD domain-containing protein 4 HOLleu_37535 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) aggrephagy [GO:0035973]; endosome organization [GO:0007032]; mitophagy [GO:0000423]; signal transduction [GO:0007165] aggresome [GO:0016235]; amphisome [GO:0044753]; nucleus [GO:0005634] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; protein kinase C binding [GO:0005080]; zinc ion binding [GO:0008270] 1 0.9 1.0278 -23.442 CKVCDDYDLCEC 0 0 0 0 0 0 0 0 0 0 0 0 20.9858 20.2288 20.2288 0 0 0 A0A9Q0YL42 A0A9Q0YL42_HOLLE Sulfotransferase HOLleu_34484 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.4 0.99858 -4.979 LRRYVLRRTT 0 0 0 0 18.9845 18.9845 21.786 21.6042 21.6042 0 0 0 0 22.2637 22.2637 0 0 15.7504 A0A9Q0YL50 A0A9Q0YL50_HOLLE CMP/dCMP-type deaminase domain-containing protein HOLleu_35667 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 5 10.7 0.99751 -49.035 CGYSGESYVWCYLEDGGWEY;CTSNCEQYGESYDWCSAGSE;DYAWCYTNDGSWDYCCTG;HSCGYHGYDYS;SNWDYCCSSSC 23.2269 0 0 0 0 0 0 0 0 23.554 0 0 19.6094 0 0 0 0 0 A0A9Q0YL80 A0A9Q0YL80_HOLLE Calpain-7 HOLleu_34465 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] 1 1 1.0209 -23.723 PRISQGGGG 0 0 0 0 0 0 0 0 0 23.4624 0 0 0 0 0 0 0 0 A0A9Q0YL88 A0A9Q0YL88_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_37663 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 0.8 1.025 -5.5496 FVLERRCVFWD 18.4069 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLA7 A0A9Q0YLA7_HOLLE Uncharacterized protein HOLleu_37706 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.9 1.0209 -23.723 MFCYYQASN 0 19.511 19.511 0 0 0 0 0 0 17.0782 0 0 0 0 0 0 0 0 A0A9Q0YLA8 A0A9Q0YLA8_HOLLE Endonuclease-reverse transcriptase HOLleu_35835 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 19.5 1.0055 -2.5328 DVLNRVKAKKKLLSELKNRKLQ 23.4977 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLC8 A0A9Q0YLC8_HOLLE Kin of IRRE-like protein 1 HOLleu_34410 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.3 0.99858 -4.979 LPILLVISTT 0 0 0 21.5044 0 0 22.5491 22.3091 22.3091 0 0 0 0 0 0 0 0 0 A0A9Q0YLD5 A0A9Q0YLD5_HOLLE Protein FAM221A HOLleu_34656 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 1.0035 -23.777 RDGGFSDE 0 0 0 18.0815 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLD9 A0A9Q0YLD9_HOLLE Neurotrypsin HOLleu_36054 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zymogen activation [GO:0031638] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] 1 2.4 0.94062 -0.068637 PLKPPVNI 0 20.1554 20.1554 17.2574 17.0238 17.0238 19.3158 19.0356 19.0356 20.7223 19.9865 19.9865 17.6773 17.4026 17.4026 0 0 0 A0A9Q0YLE1 A0A9Q0YLE1_HOLLE S-crystallin 4 HOLleu_37774 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutathione metabolic process [GO:0006749] glutathione transferase activity [GO:0004364] 1 6.4 1.0049 -6.2493 PKLKALLEKIKAH 0 0 0 0 0 0 0 24.2222 24.2222 0 0 0 0 0 0 0 0 0 A0A9Q0YLF7 A0A9Q0YLF7_HOLLE Carbohydrate sulfotransferase (EC 2.8.2.-) HOLleu_37118 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate biosynthetic process [GO:0016051]; proteoglycan biosynthetic process [GO:0030166] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] 1 2.5 1.0183 -2.6427 DFDMFGYDM 23.589 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLG5 A0A9Q0YLG5_HOLLE Aladin HOLleu_34704 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleocytoplasmic transport [GO:0006913] nuclear pore [GO:0005643] 1 1.5 1.0031 -23.777 SDEDHADN 17.64 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLH7 A0A9Q0YLH7_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_37158 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dephosphorylation [GO:0016311] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] protein tyrosine phosphatase activity [GO:0004725] 1 0.3 0.99858 -4.979 HKVAKSKKSS 0 23.9554 23.9554 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLJ4 A0A9Q0YLJ4_HOLLE Uncharacterized protein HOLleu_34762 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.8 1.0031 -23.777 CNHVFTIE 0 18.4966 18.4966 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLP8 A0A9Q0YLP8_HOLLE AP-2 complex subunit alpha HOLleu_36135 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] AP-2 adaptor complex [GO:0030122] clathrin adaptor activity [GO:0035615] 2 1.6 1.0064 -23.845 INLKLPVM;TPGAEENF 23.3723 0 0 0 0 0 0 0 0 17.5453 22.2228 22.2228 20.6466 19.9582 19.9582 0 0 0 A0A9Q0YLP9 A0A9Q0YLP9_HOLLE "WW domain binding protein VOPP1 (Vesicular, overexpressed in cancer, prosurvival protein 1)" HOLleu_34767 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] 1 9 0.99629 -4.7869 DYTNEQYYICRTDQYCCE 0 0 0 0 0 0 0 0 0 22.3511 22.1335 22.1335 0 0 0 0 0 0 A0A9Q0YLQ7 A0A9Q0YLQ7_HOLLE Cullin-associated NEDD8-dissociated protein 1 HOLleu_40974 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265] nucleus [GO:0005634] 1 0.7 1.0166 -2.6427 VETLCNNML 21.0962 24.2235 24.2235 0 0 0 0 0 0 0 20.877 20.877 0 0 0 0 0 0 A0A9Q0YLR7 A0A9Q0YLR7_HOLLE ZP domain-containing protein HOLleu_36324 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface [GO:0009986]; extracellular space [GO:0005615]; membrane [GO:0016020] 1 1.3 1.0153 -6.0118 TDTNEEGEDCTP 0 0 0 0 0 0 23.0633 23.1775 23.1775 0 22.3463 22.3463 19.3215 18.7074 18.7074 0 0 0 A0A9Q0YLS2 A0A9Q0YLS2_HOLLE Uncharacterized protein HOLleu_37370 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.9 0.99786 -4.979 CTCSDCSSLN 0 0 0 0 22.1254 22.1254 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLT3 A0A9Q0YLT3_HOLLE Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 HOLleu_34818 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263] 1 3.5 1.0256 -5.5496 PENIQFMALLH 21.2159 23.7477 23.7477 0 0 0 19.766 0 19.9805 21.0971 20.8391 20.8391 19.1583 19.1314 19.1314 0 0 0 A0A9Q0YLU3 A0A9Q0YLU3_HOLLE Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 HOLleu_34838 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.4 1.0141 -6.0118 LLLLVLLFFETT 0 0 0 0 0 0 0 21.6988 21.6988 0 0 0 0 0 0 0 0 0 A0A9Q0YLV1 A0A9Q0YLV1_HOLLE "60 kDa heat shock protein, mitochondrial" HOLleu_34855 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) apoptotic mitochondrial changes [GO:0008637]; chaperone cofactor-dependent protein refolding [GO:0051085]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell activation [GO:0050870]; positive regulation of type II interferon production [GO:0032729]; protein import into mitochondrial intermembrane space [GO:0045041]; protein refolding [GO:0042026]; response to heat [GO:0009408] GroEL-GroES complex [GO:1990220]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] 4 3.4 0.99819 -34.136 AMGGMGGM;AMGGMGGMGGMG;GMGGMGGM;MGGMGGMG 0 20.8249 20.8249 0 0 0 22.8555 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLW4 A0A9Q0YLW4_HOLLE EF-hand calcium-binding domain-containing protein 6 HOLleu_38128 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 0.9 1.0063 -23.777 RSKVDYRW 22.9144 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YLY0 A0A9Q0YLY0_HOLLE WD repeat-containing protein 46 HOLleu_34842 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] 1 1.6 0.99786 -4.979 KIPLKKVQKY 23.7438 0 0 0 22.0706 22.0706 0 24.1378 24.1378 0 0 0 0 0 0 19.3886 0 0 A0A9Q0YM01 A0A9Q0YM01_HOLLE Paraneoplastic antigen Ma-like C-terminal domain-containing protein HOLleu_34967 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 1.027 -23.723 KPICRFCNI 0 0 0 18.2645 0 0 0 0 0 0 0 0 18.3987 19.4397 19.4397 0 0 0 A0A9Q0YM08 A0A9Q0YM08_HOLLE EGF-like domain-containing protein HOLleu_36497 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.5 1.0158 -2.6427 VSRGNALRA 0 0 0 21.3069 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YM12 A0A9Q0YM12_HOLLE Sialidase HOLleu_34989 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] 1 1.2 1.014 -6.0118 HSNWEMNCNCCK 0 24.6187 24.6187 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YM37 A0A9Q0YM37_HOLLE Indole-3-acetic acid-amido synthetase GH3.1 HOLleu_34980 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; membrane [GO:0016020] indole-3-acetic acid amido synthetase activity [GO:0010279] 1 3.8 0.96154 -0.17167 EREFKKGFDGIIRRVWPDMAFIMSI 19.6254 0 0 0 18.9464 18.9464 20.3562 20.2314 20.2314 21.698 21.28 21.28 0 19.8503 19.8503 0 0 18.4876 A0A9Q0YM42 A0A9Q0YM42_HOLLE Proline-rich AKT1 substrate 1 HOLleu_36556 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of TOR signaling [GO:0032007]; neurotrophin TRK receptor signaling pathway [GO:0048011] cytoplasm [GO:0005737] 1 3.1 1.0049 -6.2493 TYKCSNCETWCYA 0 0 0 0 0 0 0 0 0 0 23.3516 23.3516 0 0 0 0 0 0 A0A9Q0YM44 A0A9Q0YM44_HOLLE Translational activator of cytochrome c oxidase 1 HOLleu_35001 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytosol [GO:0005829]; mitochondrion [GO:0005739] 1 2.4 1.0067 -23.777 VKHIKGPK 0 0 0 0 16.6161 16.6161 0 0 0 19.4452 0 0 0 0 0 0 0 0 A0A9Q0YM53 A0A9Q0YM53_HOLLE Uncharacterized protein HOLleu_36576 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1 -4.979 WFEQSDSDDE 0 23.1427 23.1427 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YM76 A0A9Q0YM76_HOLLE RNA-binding protein 45 HOLleu_35076 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) RNA binding [GO:0003723] 2 3.4 1.0056 -23.976 PAASSGNH;RDDHRRDRDRG 0 0 0 18.3786 18.724 18.724 0 0 0 20.3316 0 0 0 0 0 0 0 0 A0A9Q0YM83 A0A9Q0YM83_HOLLE WAP four-disulfide core domain protein 3 HOLleu_38633 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] 1 4.5 1.0257 -5.5496 QECTSDDDCPD 0 23.3357 23.3357 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YM92 A0A9Q0YM92_HOLLE Corticotropin-releasing factor receptor 1 HOLleu_35118 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] corticotrophin-releasing factor receptor activity [GO:0015056]; corticotropin-releasing hormone receptor activity [GO:0043404]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046] 2 7 1.0068 -6.3892 ISYVFPIFVLNLIKGLPKIVLVVI;TYTAECSNDMQGLH 0 0 0 0 0 0 0 0 0 24.8357 0 0 0 0 0 0 0 0 A0A9Q0YMB9 A0A9Q0YMB9_HOLLE Betaine--homocysteine S-methyltransferase 1 HOLleu_35272 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] 1 4.8 0.99929 -4.979 IELLLPIGVP 0 0 0 0 0 0 20.1881 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YMD9 A0A9Q0YMD9_HOLLE SAM domain-containing protein HOLleu_35311 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.8 1.0045 -26.085 AEAEESDEESDE;VSTEHKLLR 0 23.2153 23.261 0 0 0 18.1444 17.0632 17.0632 0 20.3856 20.3856 0 18.5349 18.5349 0 0 0 A0A9Q0YME4 A0A9Q0YME4_HOLLE Cytochrome b reductase 1 HOLleu_35253 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] oxidoreductase activity [GO:0016491] 1 3.2 1.0071 -23.777 YHRQHGYP 0 0 0 0 0 0 0 0 0 0 0 0 0 19.8834 19.8834 0 0 0 A0A9Q0YMG4 A0A9Q0YMG4_HOLLE G-protein coupled receptor moody HOLleu_35233 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] 2 5.9 1.0056 -8.3965 IHRIVVAVI;IIIFSYTWLYIHIRL 0 0 0 0 0 0 0 0 0 21.3167 21.3329 21.3329 24.5097 0 0 0 0 0 A0A9Q0YMM1 A0A9Q0YMM1_HOLLE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HOLleu_35433 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of membrane depolarization [GO:0003254]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855] voltage-gated potassium channel activity [GO:0005249] 1 1.3 0.94025 -0.068637 LLRLTRLM 0 0 0 0 0 0 0 24.0674 24.0674 0 0 0 0 0 0 0 0 0 A0A9Q0YMT2 A0A9Q0YMT2_HOLLE Uncharacterized protein HOLleu_32897 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome assembly [GO:0006334] nucleosome [GO:0000786] DNA binding [GO:0003677]; structural constituent of chromatin [GO:0030527] 1 11.1 1.015 -2.2078 RRREEEEKKKKKKKKKKKKKKKK 0 0 0 0 22.2987 22.2987 0 0 0 0 0 0 0 0 0 0 22.0045 22.0045 A0A9Q0YMT6 A0A9Q0YMT6_HOLLE Heat shock 70 kDa protein 12A HOLleu_32894 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 0.9 1.0018 -27.963 SDDEEEKE;SSSSCSSESDE;YHDMNFTEAQKWLYFDKYKLTL 18.2261 0 0 0 0 0 0 0 0 21.4988 20.9063 20.9063 16.7612 0 0 0 0 0 A0A9Q0YMV5 A0A9Q0YMV5_HOLLE Nuclear pore complex protein HOLleu_32935 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA export from nucleus [GO:0006406]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606] nuclear membrane [GO:0031965]; nuclear pore outer ring [GO:0031080] structural constituent of nuclear pore [GO:0017056] 1 1.6 1.0171 -5.7538 FVDGGWMVDQQASMD 23.2344 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YMX7 A0A9Q0YMX7_HOLLE Biorientation of chromosomes in cell division protein 1-like 1 HOLleu_32969 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell division [GO:0051301] 1 0.5 0.93478 -0.068637 LEETGVGH 0 0 0 0 0 0 20.4223 20.1561 20.1561 18.4844 18.0908 18.0908 0 0 0 0 0 0 A0A9Q0YN11 A0A9Q0YN11_HOLLE G protein-coupled receptor kinase (EC 2.7.11.-) HOLleu_33047 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165] cytoplasm [GO:0005737] ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703] 3 6.5 0.99645 -51.256 MHQLAHDIYNKYIAPEAPIRL;VNAKRGGG;YRVLGKGGF 0 0 0 0 0 0 20.9032 0 18.408 0 0 0 19.4764 19.8337 19.8337 0 0 0 A0A9Q0YN20 A0A9Q0YN20_HOLLE DNA-directed DNA polymerase (EC 2.7.7.7) HOLleu_36096 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA replication [GO:0006260] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166] 2 1.5 0.99709 -29.789 AGYDLEEIWECD;NICLGCFN 0 20.0899 20.0899 0 0 0 0 0 0 18.55 0 0 22.5261 0 0 0 0 0 A0A9Q0YN38 A0A9Q0YN38_HOLLE Nucleolar protein 14 HOLleu_33006 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) maturation of SSU-rRNA [GO:0030490] Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] 1 1.1 0.99781 -4.979 GEEDDSDMEE 0 21.8195 21.8195 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YN52 A0A9Q0YN52_HOLLE Sulfotransferase family cytosolic 2B member 1 HOLleu_36151 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sulfation [GO:0051923] cytoplasm [GO:0005737] sulfotransferase activity [GO:0008146] 1 2.5 1.0051 -23.777 PKIIYIYR 0 0 0 0 0 0 0 0 0 21.4723 0 0 0 0 0 0 0 0 A0A9Q0YNB6 A0A9Q0YNB6_HOLLE Nuclear pore complex protein Nup50 HOLleu_36271 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein import into nucleus [GO:0006606] 1 2.6 1.023 -5.5496 DNWQDEEEEDE 0 0 0 0 0 0 0 0 0 0 24.321 24.321 0 0 0 0 0 0 A0A9Q0YNE4 A0A9Q0YNE4_HOLLE ATP-dependent DNA helicase (EC 3.6.4.12) HOLleu_33236 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] 3 1.7 1.0127 -13.21 EDDNEDEWDIQEQDDNTT;EMTPDSDDEWTEE;ILLKPLDY 19.9245 20.8978 20.8978 0 0 0 22.3761 0 0 20.8971 20.6199 20.6199 0 0 0 0 0 0 A0A9Q0YNF5 A0A9Q0YNF5_HOLLE Zonadhesin HOLleu_33331 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012] extracellular matrix structural constituent [GO:0005201] 1 0.7 1.0236 -5.5496 WGDPHFGTCDG 20.1624 21.5719 21.5719 0 15.2664 0 16.3507 0 0 21.8807 20.1786 20.1786 17.7975 17.4799 17.4799 0 0 0 A0A9Q0YNH8 A0A9Q0YNH8_HOLLE Gustatory receptor HOLleu_33371 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 1.0115 -2.6427 KPLPKIGVV 25.1925 24.4839 24.4839 0 0 0 0 0 0 0 24.1746 24.1746 23.4443 23.1392 23.1392 0 0 0 A0A9Q0YNJ2 A0A9Q0YNJ2_HOLLE Tetraspanin HOLleu_35927 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of vascular endothelial growth factor signaling pathway [GO:1900746] membrane [GO:0016020] 2 11.7 1.0103 -7.4296 CGIDGPSDWMTNGNFDDN;SCMVQSAYT 0 19.8714 19.8714 0 0 0 21.5494 24.9232 24.9232 0 0 0 23.9747 0 0 0 0 0 A0A9Q0YNJ8 A0A9Q0YNJ8_HOLLE Dysferlin HOLleu_33409 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane fusion [GO:0061025]; plasma membrane organization [GO:0007009] cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] 1 0.4 1.0149 -2.6427 APGAGDGDG 0 0 0 0 0 0 0 0 0 0 0 0 21.7897 21.7164 21.7164 0 0 0 A0A9Q0YNL3 A0A9Q0YNL3_HOLLE Uncharacterized protein HOLleu_33428 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.9 1.0039 -23.777 CKTCHVTT 0 0 0 0 0 0 18.7814 18.8566 18.8566 0 0 0 0 0 0 0 0 0 A0A9Q0YNP8 A0A9Q0YNP8_HOLLE Nematocin receptor 2 HOLleu_33468 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] 1 2.3 0.87129 -0.068637 PEALVATT 22.5854 23.9408 23.9408 0 0 0 0 0 0 22.8035 0 0 18.6284 0 0 0 0 0 A0A9Q0YNQ1 A0A9Q0YNQ1_HOLLE C2H2-type domain-containing protein HOLleu_33485 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 2 3.7 1.0026 -27.694 HEIIHQKEKPFKCT;YQCRMCTFED 0 21.4853 21.4853 0 0 0 17.982 18.0021 18.0021 19.9253 19.4649 19.4649 0 0 0 0 0 0 A0A9Q0YNR7 A0A9Q0YNR7_HOLLE Hexosyltransferase (EC 2.4.1.-) HOLleu_34666 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chondroitin sulfate biosynthetic process [GO:0030206] Golgi cisterna membrane [GO:0032580] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238] 1 1.8 1.0166 -22.715 DLDLFEMFLNAKVH 20.0466 23.0082 23.0082 0 17.8134 17.8134 0 19.2275 19.2275 20.2254 20.3835 20.3835 18.3207 18.9127 18.9127 0 0 0 A0A9Q0YNV1 A0A9Q0YNV1_HOLLE Prolyl 4-hydroxylase 4 HOLleu_34769 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] 1 3.2 1.0174 -21.924 IFLVVGLMIFPPWGK 0 0 0 0 0 0 0 0 0 21.1028 20.9235 20.9235 0 0 0 0 0 0 A0A9Q0YP01 A0A9Q0YP01_HOLLE DNA replication complex GINS protein SLD5 HOLleu_33619 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA-templated DNA replication [GO:0006261]; double-strand break repair via break-induced replication [GO:0000727] GINS complex [GO:0000811] 1 4.9 1.0241 -5.5496 ALDESYDEEHE 0 0 0 0 0 0 0 0 0 22.1792 0 0 0 0 0 0 0 0 A0A9Q0YP12 A0A9Q0YP12_HOLLE FGFR1 oncogene partner 2-like HOLleu_36247 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 1.0247 -5.5496 DCDETYCFQME 0 0 0 0 0 0 0 0 0 24.7828 0 0 0 0 0 0 0 0 A0A9Q0YP14 A0A9Q0YP14_HOLLE Folliculin-interacting protein 1 HOLleu_37558 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lysosomal membrane [GO:0005765] ATPase inhibitor activity [GO:0042030]; protein-folding chaperone binding [GO:0051087] 1 1.8 1.0023 -4.125 LNTSSCSSQDGSSSDGSSNE 0 22.1116 22.1116 0 0 0 0 18.2179 18.2179 0 0 0 0 0 0 0 0 0 A0A9Q0YP15 A0A9Q0YP15_HOLLE Ellis-van Creveld syndrome protein HOLleu_33660 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane protein complex [GO:0098797] 1 1.4 1.007 -6.2493 QDTAMEHDEDETE 0 21.253 21.253 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YP18 A0A9Q0YP18_HOLLE Nucleolar MIF4G domain-containing protein 1 HOLleu_34928 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ribosomal small subunit biogenesis [GO:0042274] nucleolus [GO:0005730] RNA binding [GO:0003723] 1 1.3 1.008 -6.0118 EGEGSDCDSRDD 0 0 0 0 0 0 0 0 0 26.0161 0 0 0 0 0 0 0 0 A0A9Q0YP26 A0A9Q0YP26_HOLLE Rho GTPase-activating protein 19 HOLleu_33673 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] 1 3.8 1.0166 -5.6907 LKVLRRANHIKALRYLAFLLPP 19.5455 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YP36 A0A9Q0YP36_HOLLE Exocyst complex component Sec8 HOLleu_33689 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chemical synaptic transmission [GO:0007268]; Golgi to plasma membrane transport [GO:0006893]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] exocyst [GO:0000145]; growth cone membrane [GO:0032584]; synapse [GO:0045202] 1 7.4 1.0157 -22.715 KMNQYITEKRYLHA 0 0 0 0 0 0 0 0 0 18.0119 0 0 0 0 0 0 0 0 A0A9Q0YP51 A0A9Q0YP51_HOLLE Indole-3-acetic acid-amido synthetase GH3.17 HOLleu_36775 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; membrane [GO:0016020] indole-3-acetic acid amido synthetase activity [GO:0010279] 1 1.4 1.0183 -23.723 WQPMRPKLF 19.835 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YP69 A0A9Q0YP69_HOLLE Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) HOLleu_33726 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) L-phenylalanine catabolic process [GO:0006559]; tetrahydrobiopterin biosynthetic process [GO:0006729] cytoplasm [GO:0005737] "6,7-dihydropteridine reductase activity [GO:0004155]; NADH binding [GO:0070404]; NADPH binding [GO:0070402]" 1 3.1 0.96264 -0.068637 GMAKAAVH 0 0 0 19.0224 0 0 0 0 0 21.9577 21.3654 21.3654 0 0 0 0 0 16.7998 A0A9Q0YP71 A0A9Q0YP71_HOLLE Bcl-2 Bcl-2 homology region 1-3 domain-containing protein HOLleu_33748 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] 1 11.8 1.0087 -5.3628 SSEGESSEDDTVTDNDGEEDDGS 0 18.6069 18.6069 0 0 0 0 0 0 0 17.2483 17.2483 0 0 0 0 0 0 A0A9Q0YP91 A0A9Q0YP91_HOLLE E3 ubiquitin-protein ligase KCMF1 (RING-type E3 ubiquitin transferase KCMF1) HOLleu_33724 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) synaptic signaling [GO:0099536] plasma membrane [GO:0005886] zinc ion binding [GO:0008270] 1 2.5 0.99708 -4.979 YDYDLCAQCY 0 20.8267 20.8267 0 0 0 0 0 0 18.3659 0 0 0 0 0 0 0 0 A0A9Q0YPD0 A0A9Q0YPD0_HOLLE Insulin-like growth factor-binding protein-related protein 1 HOLleu_33853 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] insulin-like growth factor binding [GO:0005520] 1 8.3 1.0131 -2.2078 GCCYVCGNEEWYYCDPDPTDYPE 0 0 0 0 0 0 0 22.8114 22.8114 0 0 0 0 0 0 0 0 0 A0A9Q0YPD5 A0A9Q0YPD5_HOLLE Ciliary microtubule inner protein 2A-C-like domain-containing protein HOLleu_33839 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] 1 3.3 1.0242 -5.5496 EDCDVCIDDFM 0 22.8703 22.8703 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YPE1 A0A9Q0YPE1_HOLLE Uncharacterized protein HOLleu_33874 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.7 1.0044 -6.2493 YHGDSDCDLEDDE 0 0 0 0 0 0 0 0 0 22.2871 0 0 0 0 0 0 0 0 A0A9Q0YPF7 A0A9Q0YPF7_HOLLE Ankyrin and armadillo repeat-containing protein HOLleu_35223 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0157 -6.0779 PTQPLWVHAFYEKI 22.98 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YPG4 A0A9Q0YPG4_HOLLE receptor protein-tyrosine kinase (EC 2.7.10.1) HOLleu_35244 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; growth factor binding [GO:0019838]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 1 1.1 1 -4.564 HTESNGNCNQTSTGGTCDS 0 0 0 0 0 0 23.077 21.4912 21.4912 0 0 0 0 0 0 15.981 0 17.2452 A0A9Q0YPG5 A0A9Q0YPG5_HOLLE "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-methylbutyryl-coenzyme A dehydrogenase)" HOLleu_33901 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrion [GO:0005739] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] 1 1.8 1.0155 -23.777 KKKYLPKL 0 0 0 0 20.9286 20.9286 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YPH6 A0A9Q0YPH6_HOLLE Bardet-Biedl syndrome 12 protein-like HOLleu_35260 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chaperone-mediated protein complex assembly [GO:0051131]; photoreceptor cell maintenance [GO:0045494] ATP binding [GO:0005524] 1 0.7 0.071429 -0.068637 EPPMMSYF 0 0 0 0 19.5237 0 0 0 0 22.8656 22.6041 22.6041 21.4581 21.9228 21.9228 0 0 0 A0A9Q0YPK7 A0A9Q0YPK7_HOLLE DNA cross-link repair 1A protein HOLleu_32899 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297] 5'-3' DNA exonuclease activity [GO:0035312]; damaged DNA binding [GO:0003684] 1 1.1 1.0042 -23.777 RKSVKGKT 0 0 0 17.3119 0 0 0 0 0 20.3335 0 0 0 0 0 15.4084 0 0 A0A9Q0YPM1 A0A9Q0YPM1_HOLLE "Protein Skeletor, isoforms B/C" HOLleu_34023 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 1.1 1.0104 -6.0118 DTQPCQNGGTCT 0 0 0 0 0 0 23.2269 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YPM7 A0A9Q0YPM7_HOLLE "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" HOLleu_34026 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 3 8.3 0.99964 -35.77 CPCNYCHPELCPEG;IAALVAIVIRRR;NQVNPLCACCAKE 21.423 21.7469 21.7469 0 0 0 0 0 0 20.7096 23.1987 23.1987 0 0 0 0 0 0 A0A9Q0YPU8 A0A9Q0YPU8_HOLLE Transmembrane protein 129 HOLleu_34202 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein ubiquitination [GO:0016567] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ubiquitin protein ligase activity [GO:0061630] 1 2.1 1.0146 -23.777 SHESSAGA 0 0 0 0 0 0 0 0 0 0 19.4976 19.4976 0 0 0 0 0 0 A0A9Q0YPV6 A0A9Q0YPV6_HOLLE B box-type domain-containing protein HOLleu_38130 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 1 2.9 0.99558 -4.7869 EEYGKDDDEADDENHELT 0 0 0 0 0 0 0 0 0 0 21.6997 21.6997 0 0 0 0 0 0 A0A9Q0YPZ9 A0A9Q0YPZ9_HOLLE Uncharacterized protein HOLleu_31252 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 1.0108 -11.621 HSVCQNWEETVCYWEPYC 0 0 0 0 0 0 19.7057 20.0817 20.0817 0 0 0 0 0 0 0 0 0 A0A9Q0YQ07 A0A9Q0YQ07_HOLLE Uncharacterized protein HOLleu_31272 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.6 0.97708 -0.068637 YSDETMEG 0 0 0 0 0 0 0 0 0 23.2887 0 0 0 0 0 0 0 0 A0A9Q0YQ08 A0A9Q0YQ08_HOLLE ELL-associated factor 1 HOLleu_34528 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA-templated transcription [GO:0006355]; transcription elongation by RNA polymerase II [GO:0006368] super elongation complex [GO:0032783] transcription elongation factor activity [GO:0003711] 1 3.4 1.0247 -5.5496 EEDEDESSSNN 23.7388 0 0 0 0 0 0 0 0 0 23.2349 23.2349 0 0 0 0 0 0 A0A9Q0YQ09 A0A9Q0YQ09_HOLLE Uncharacterized protein HOLleu_38247 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 1.024 -5.5496 GWMCTTCQEGY 0 29.0322 29.0322 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YQ27 A0A9Q0YQ27_HOLLE Angiopoietin-related protein 1 HOLleu_31295 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.2 1.0175 -6.0779 WWHSKEWCNECCHS 0 21.1612 21.1612 16.7073 0 0 18.7501 18.8867 18.8867 20.303 19.4653 19.4653 0 18.4291 18.4291 0 0 0 A0A9Q0YQA2 A0A9Q0YQA2_HOLLE Kelch-like protein 10 HOLleu_34601 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 2.5 1.0007 -4.979 EDEDEDDD;QQWESCPSMY 0 0 0 0 0 0 0 0 0 22.5518 0 0 0 0 0 0 0 0 A0A9Q0YQA8 A0A9Q0YQA8_HOLLE Uncharacterized protein HOLleu_31509 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled peptide receptor activity [GO:0008528] 2 0.6 0.99744 -29.224 DETDCEYPAC;PACEVDEYQCD 19.9506 22.5984 22.5984 0 0 0 0 0 0 24.7673 24.3313 24.3313 22.9154 22.5495 22.5495 0 0 0 A0A9Q0YQE0 A0A9Q0YQE0_HOLLE Uncharacterized protein HOLleu_33529 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 10.3 1.0109 -11.561 ACQPPDCDRNDC;CDRNDCGSCGN 0 16.8366 16.8366 0 0 0 22.8481 21.3863 21.3863 16.6161 16.8402 16.8402 23.6423 16.6822 16.6822 0 0 0 A0A9Q0YQE5 A0A9Q0YQE5_HOLLE Carboxypeptidase N subunit 2 HOLleu_31588 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] carboxypeptidase activity [GO:0004180] 2 4.3 1.0132 -13.054 LLKNLPKLRKLFLAQNKI;PIKLLKNLPKLRKLFLAQNK 0 22.0798 22.0798 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YQJ2 A0A9Q0YQJ2_HOLLE Baculoviral IAP repeat-containing protein 7-B HOLleu_31777 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630] 1 1.2 1.0015 -4.979 KGDNPWDEHA 0 0 0 0 0 0 20.2167 23.257 23.257 0 0 0 0 0 0 0 0 0 A0A9Q0YQK5 A0A9Q0YQK5_HOLLE Stereocilin HOLleu_34768 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] cell surface [GO:0009986] 1 0.9 1.0134 -6.0118 GDPSTWDQEEMS 0 24.4118 24.4118 0 0 0 0 0 0 24.9064 23.8293 23.8293 0 0 0 0 0 0 A0A9Q0YQL4 A0A9Q0YQL4_HOLLE Serine/arginine repetitive matrix protein 1 HOLleu_31699 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA processing [GO:0006397]; regulation of mRNA splicing, via spliceosome [GO:0048024]" spliceosomal complex [GO:0005681] RNA binding [GO:0003723] 1 2.7 0.98161 -0.20876 AKKKKKKEKKHKKHKKHKKHKKMK 20.5114 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YQL5 A0A9Q0YQL5_HOLLE "ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific] (EC 2.5.1.87)" HOLleu_31567 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dolichol biosynthetic process [GO:0019408]; protein glycosylation [GO:0006486] dehydrodolichyl diphosphate synthase complex [GO:1904423]; endoplasmic reticulum membrane [GO:0005789] dehydrodolichyl diphosphate synthase activity [GO:0045547] 1 3.1 1.0271 -23.723 LLYRTVHAV 19.5172 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YQM9 A0A9Q0YQM9_HOLLE Meiotic recombination protein REC8-like HOLleu_33359 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sister chromatid cohesion [GO:0007062] cohesin complex [GO:0008278]; nucleus [GO:0005634] chromatin binding [GO:0003682] 1 1.3 1.017 -23.723 RKIAAKIFA 0 0 0 19.6662 19.0704 19.0704 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YQQ1 A0A9Q0YQQ1_HOLLE Angiopoietin-related protein 1 HOLleu_31621 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 4.3 1.0102 -16.446 CYSNYCGNFQQGGCYTSCTY;WCPNCYSNYCGNFQQG 0 20.5789 20.5789 0 0 0 0 21.4492 21.4492 0 0 0 0 0 0 0 0 0 A0A9Q0YQQ6 A0A9Q0YQQ6_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_31776 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1 1.0171 -23.777 VHDCTHDE 0 17.7506 17.7506 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YQR3 A0A9Q0YQR3_HOLLE Adenylate kinase 9 HOLleu_31686 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) CDP biosynthetic process [GO:0046705]; phosphorylation [GO:0016310]; UDP biosynthetic process [GO:0006225] cytosol [GO:0005829]; nucleus [GO:0005634] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550]; UMP kinase activity [GO:0033862] 1 0.4 1.0174 -2.6427 VRLVMLGPR 22.8596 0 0 0 0 0 0 0 0 0 0 0 22.6279 0 0 0 0 0 A0A9Q0YQX1 A0A9Q0YQX1_HOLLE Synaptic vesicular amine transporter HOLleu_33857 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) aminergic neurotransmitter loading into synaptic vesicle [GO:0015842] synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] serotonin:sodium:chloride symporter activity [GO:0005335] 1 2 1.0252 -5.5496 EIVSTAEECHE 0 0 0 0 0 0 22.1432 21.7877 21.7877 0 0 0 0 0 0 0 0 0 A0A9Q0YQZ8 A0A9Q0YQZ8_HOLLE Uncharacterized protein HOLleu_31973 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0138 -23.777 INVLHLIA 18.5053 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YR37 A0A9Q0YR37_HOLLE Cilia- and flagella-associated protein 69 HOLleu_35186 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) olfactory behavior [GO:0042048]; positive regulation of flagellated sperm motility [GO:1902093]; response to odorant [GO:1990834] non-motile cilium [GO:0097730]; sperm midpiece [GO:0097225] 2 3.7 1.0214 -1.4337 ANTILSIYIRKPSNQAFRDQLPCSQ;YLKTDPKKL 0 0 0 0 0 0 0 0 0 0 21.2228 21.2228 0 0 0 0 0 0 A0A9Q0YR46 A0A9Q0YR46_HOLLE Peroxisomal (S)-2-hydroxy-acid oxidase GLO5 HOLleu_31956 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid alpha-oxidation [GO:0001561]; lactate oxidation [GO:0019516] peroxisome [GO:0005777]; plasma membrane [GO:0005886] FMN binding [GO:0010181]; L-lactate dehydrogenase activity [GO:0004459] 1 6.5 0.97043 -0.17167 AWLKSETKLPIVLKGILTAKAARRA 0 0 0 0 0 0 0 0 0 0 0 0 0 21.6904 21.6904 0 0 0 A0A9Q0YR47 A0A9Q0YR47_HOLLE Serine-protein kinase ATM HOLleu_32194 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281]; phosphorylation [GO:0016310] protein serine/threonine kinase activity [GO:0004674] 1 0.3 1.013 -23.777 EKSHTMED 0 18.9769 18.9769 0 0 0 19.1341 0 0 0 0 0 16.7691 16.2726 16.2726 0 0 0 A0A9Q0YR59 A0A9Q0YR59_HOLLE Uncharacterized protein HOLleu_34802 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.3 0.9419 -0.068637 HEHETTGF 0 0 0 0 0 0 16.781 0 16.8323 21.8169 0 0 16.7243 0 0 0 0 0 A0A9Q0YR94 A0A9Q0YR94_HOLLE Cleavage stimulation factor subunit 2 HOLleu_32160 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA 3'-end processing [GO:0031124] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] mRNA binding [GO:0003729] 1 1.8 1.0113 -23.777 PMGAPGGA 0 0 0 0 0 0 0 0 0 20.917 0 0 0 0 0 0 0 0 A0A9Q0YRA9 A0A9Q0YRA9_HOLLE Cation-independent mannose-6-phosphate receptor HOLleu_32091 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lysosomal transport [GO:0007041] late endosome [GO:0005770]; plasma membrane [GO:0005886] insulin-like growth factor binding [GO:0005520]; mannose binding [GO:0005537]; signaling receptor activity [GO:0038023] 3 1.2 0.99783 -31.154 FSDSDDDCTYSF;PDGSTSSC;YFINVCKPA 0 19.2444 19.2444 0 0 0 21.3139 0 0 17.159 16.2104 16.2104 0 16.299 16.299 0 0 0 A0A9Q0YRB5 A0A9Q0YRB5_HOLLE Uncharacterized protein HOLleu_34966 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 0.90909 -0.068637 KVSRKASK 21.2494 21.8232 21.8232 0 18.0914 18.0914 19.8652 19.6086 19.6086 21.3161 21.3402 21.3402 0 18.4812 18.4812 15.9339 0 0 A0A9Q0YRC1 A0A9Q0YRC1_HOLLE Mucin-5AC HOLleu_34988 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 4 3.2 0.99783 -31.603 ACDSACYVEGSEDFGCEETCVEG;NGNEEDDFNCG;PGETNTPG;YNGNEEDD 25.0366 25.5687 25.5687 0 0 0 21.3597 0 0 0 26.3198 26.3198 0 21.7916 21.7916 0 0 0 A0A9Q0YRD3 A0A9Q0YRD3_HOLLE RNA-binding protein 33 HOLleu_35023 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) RNA binding [GO:0003723] 3 3.7 0.99604 -34.97 ADVEEEEEQYNEGASE;DSGDASEADDDPVDDDDEDEDG;HSGGGDAP 23.8965 0 0 0 0 0 0 0 0 17.7382 19.838 19.838 0 0 0 0 0 0 A0A9Q0YRE2 A0A9Q0YRE2_HOLLE Uncharacterized protein HOLleu_35044 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.8 1.009 -2.6427 RLVMRRLTT 0 0 0 0 0 0 0 0 0 0 0 0 21.005 20.7584 20.7584 0 0 0 A0A9Q0YRF5 A0A9Q0YRF5_HOLLE E3 ubiquitin-protein ligase TRIM33 HOLleu_36542 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion binding [GO:0008270] 1 1 1.0271 -23.631 DDNAQSTWFCE 0 19.2886 19.2886 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YRF8 A0A9Q0YRF8_HOLLE Metabotropic glutamate receptor 4 HOLleu_32195 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "regulation of synaptic transmission, glutamatergic [GO:0051966]" membrane [GO:0016020] group II metabotropic glutamate receptor activity [GO:0001641] 1 1.2 1.0104 -23.777 INNHCCWE 0 0 0 0 0 0 0 0 0 0 17.0468 17.0468 14.514 0 0 0 0 0 A0A9Q0YRH4 A0A9Q0YRH4_HOLLE SNF-related serine/threonine-protein kinase HOLleu_35080 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 1 0.9 1.01 -23.777 CNDDGHGC 0 20.2721 20.2721 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YRH7 A0A9Q0YRH7_HOLLE Uncharacterized protein HOLleu_32317 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.8 0 -0.068637 SSENCNFG 0 20.5453 20.5453 0 0 0 0 0 0 21.9475 21.442 21.442 16.8629 16.5175 16.5175 0 0 0 A0A9Q0YRK4 A0A9Q0YRK4_HOLLE "Splicing factor, proline- and glutamine-rich" HOLleu_32283 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of meiotic nuclear division [GO:0045836]; regulation of DNA-templated transcription [GO:0006355] Nrd1 complex [GO:0035649]; nucleus [GO:0005634] RNA binding [GO:0003723] 2 2.3 1.0111 -2.2424 GGINTNPR;LGGDRRGD 0 0 0 0 0 0 0 0 0 23.0374 0 0 0 0 0 0 0 0 A0A9Q0YRL1 A0A9Q0YRL1_HOLLE Cytosolic purine 5'-nucleotidase HOLleu_34203 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] 1 1.4 0.93827 -0.068637 LMFDKLYG 0 0 0 0 0 0 25.8296 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YRR1 A0A9Q0YRR1_HOLLE Integrase catalytic domain-containing protein HOLleu_31340 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] 2 3.4 1.016 -5.938 YGNSSGTTSYSGSQSGS;YVEFAYQKERHFDRW 23.5299 24.4546 24.4546 16.6983 18.3064 18.3064 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YRT4 A0A9Q0YRT4_HOLLE receptor protein-tyrosine kinase (EC 2.7.10.1) HOLleu_33167 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; metal ion binding [GO:0046872] 1 1.2 1.0121 -6.0118 EEITEDNRTEEV 23.1658 0 0 0 0 0 0 0 0 0 0 0 0 21.1392 21.1392 0 0 0 A0A9Q0YRY2 A0A9Q0YRY2_HOLLE p-selectin HOLleu_34276 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576]; plasma membrane [GO:0005886] 1 1.4 1.0252 -23.027 GFYPPFSNEALCD 0 0 0 0 0 0 0 20.3496 20.3496 19.5606 18.881 18.881 0 17.0009 17.0009 0 0 0 A0A9Q0YS37 A0A9Q0YS37_HOLLE BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like HOLleu_32988 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial outer membrane permeabilization [GO:0097345]; positive regulation of apoptotic process [GO:0043065]; regulation of metabolic process [GO:0019222] endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635] identical protein binding [GO:0042802] 1 3.9 1.0246 -23.723 KPLPIHCTT 21.201 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17.3561 0 0 A0A9Q0YS39 A0A9Q0YS39_HOLLE Melatonin receptor type 1C HOLleu_34399 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] 1 5.2 0.99559 -4.7869 YFYIKRHNRNLDEIRQRM 0 0 0 0 0 0 21.335 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YS73 A0A9Q0YS73_HOLLE Uncharacterized protein HOLleu_33090 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 1.0072 -2.7235 DWSKLTDYCEQDDTTYDGDCE 0 0 0 0 0 0 0 0 0 0 0 0 0 21.8854 21.8854 0 0 0 A0A9Q0YS77 A0A9Q0YS77_HOLLE Autocrine proliferation repressor protein A HOLleu_34494 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.7 1.025 -23.723 DSHYFFDQM 0 0 0 0 0 0 0 0 0 0 0 0 18.3929 0 0 0 0 0 A0A9Q0YS83 A0A9Q0YS83_HOLLE Extracellular calcium-sensing receptor HOLleu_31851 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "regulation of synaptic transmission, glutamatergic [GO:0051966]" membrane [GO:0016020] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640] 1 1.3 1.0116 -6.0118 MLLESDAFFYNN 20.8832 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YSB0 A0A9Q0YSB0_HOLLE Sulfotransferase HOLleu_33202 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 0.75 -0.068637 DSGRDPHS 0 20.338 20.338 0 0 0 0 0 0 23.8218 0 0 20.6441 20.7934 20.7934 0 0 0 A0A9Q0YSF6 A0A9Q0YSF6_HOLLE Metabotropic glutamate receptor 8 HOLleu_32106 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "regulation of synaptic transmission, glutamatergic [GO:0051966]" plasma membrane [GO:0005886] group II metabotropic glutamate receptor activity [GO:0001641] 1 1.8 1.0213 -23.723 ENGTRCESC 0 23.0887 23.0887 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YSH1 A0A9Q0YSH1_HOLLE Protein-glucosylgalactosylhydroxylysine glucosidase HOLleu_31729 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) trehalose catabolic process [GO:0005993] cytosol [GO:0005829] "alpha,alpha-trehalase activity [GO:0004555]; protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]" 1 1.1 1.016 -2.6427 YSGYEVCPA 0 21.1946 21.1946 0 0 0 19.0134 16.6021 0 0 19.9291 19.9291 0 0 0 0 0 0 A0A9Q0YSJ2 A0A9Q0YSJ2_HOLLE E3 ubiquitin-protein ligase XIAP HOLleu_32200 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630] 1 1 0.94322 -0.068637 GMGFDAST 0 0 0 21.3763 21.205 21.205 0 0 0 25.3999 24.9975 24.9975 21.0035 20.8629 20.8629 0 0 0 A0A9Q0YSK9 A0A9Q0YSK9_HOLLE POU domain protein HOLleu_34849 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.2 1.0121 -23.777 DSPGGHGT 0 19.2278 19.2278 0 0 0 0 0 0 18.7924 18.3989 18.3989 0 0 0 0 0 0 A0A9Q0YSN1 A0A9Q0YSN1_HOLLE Bifunctional lysine-specific demethylase and histidyl-hydroxylase (EC 1.14.11.-) HOLleu_32303 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleolus [GO:0005730] histone H3K36 demethylase activity [GO:0051864]; histone H3K4 demethylase activity [GO:0032453]; iron ion binding [GO:0005506] 1 4.3 1.0112 -2.2078 DCMEEDEDGEDVAERNGDVEDDD 20.4909 20.8226 20.8226 0 0 0 0 0 0 21.3914 20.8773 20.8773 0 0 0 0 0 0 A0A9Q0YSQ1 A0A9Q0YSQ1_HOLLE Otogelin HOLleu_34993 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 3 1.7 1.0114 -7.3832 GGDCLQCEEGKVYTECGSSCNS;HCECTNGQWTCTEDECTDGETDK;QWTCTEDEC 25.2368 24.6283 24.6283 16.5299 0 0 21.3315 23.0714 23.0714 25.1767 23.399 23.399 21.1857 21.4395 21.4395 0 0 0 A0A9Q0YST5 A0A9Q0YST5_HOLLE Uncharacterized protein HOLleu_32027 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 19.5 1.021 -5.5713 FMSTVCGQYCCSFCFT;WVAMYFDD 0 0 0 0 16.0647 0 23.4814 0 0 0 20.7664 20.7664 0 0 0 0 0 0 A0A9Q0YSV9 A0A9Q0YSV9_HOLLE Bromodomain and WD repeat-containing protein 3 HOLleu_32151 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] 2 1.5 1.0108 -7.3972 DSSGDEVNMSNLSDSEE;GADGCICF 0 0 0 0 0 0 0 0 0 23.5776 0 0 0 0 0 0 0 0 A0A9Q0YT00 A0A9Q0YT00_HOLLE Fibrocystin-L HOLleu_34210 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] metal ion binding [GO:0046872] 2 0.6 1 -47.554 DNSSEYTL;SWGAVPAA 0 21.6311 21.6311 0 0 0 0 18.3854 18.3854 0 20.4359 20.4359 0 0 0 0 0 0 A0A9Q0YT42 A0A9Q0YT42_HOLLE Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) HOLleu_35441 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial glycyl-tRNA aminoacylation [GO:0070150] mitochondrion [GO:0005739] ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820]; transferase activity [GO:0016740] 1 1.7 1.0014 -4.979 NEMAHYACDC 0 24.0895 24.0895 0 0 0 0 0 0 25.4082 0 0 0 0 0 0 0 0 A0A9Q0YT61 A0A9Q0YT61_HOLLE Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) HOLleu_31388 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] NAD+ ADP-ribosyltransferase activity [GO:0003950] 2 1.3 1.0077 -6.0804 DGMHDDEP;NYAPKPRQAPRH 0 25.4962 25.4962 0 0 0 0 0 0 20.6047 0 0 0 0 0 0 0 0 A0A9Q0YT76 A0A9Q0YT76_HOLLE Transcription factor Sox-5 HOLleu_34134 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" 1 0.6 0.91205 -0.068637 PGVPNGGV 0 24.0996 24.0996 0 0 0 0 0 0 21.2484 0 0 0 0 0 0 0 0 A0A9Q0YT79 A0A9Q0YT79_HOLLE Adenosine receptor A2b HOLleu_31495 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled adenosine receptor signaling pathway [GO:0001973] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 3.2 1.0116 -6.0118 TRPFKYFTIMTT 0 23.9835 23.9835 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YT84 A0A9Q0YT84_HOLLE Sortilin-related receptor HOLleu_31514 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) clathrin-coated pit [GO:0005905]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] 1 1.2 1.0131 -5.8824 NSDETNCEYPTCESHEAECTN 0 0 0 0 0 0 0 0 0 21.4623 18.8636 18.8636 0 0 0 0 0 0 A0A9Q0YT89 A0A9Q0YT89_HOLLE Neurotrypsin HOLleu_31532 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 6 1.0149 -5.8824 RYLADCENDGWYYNNCDHNED 0 0 0 0 0 0 17.4598 20.8073 20.8073 0 0 0 0 0 0 0 0 0 A0A9Q0YT91 A0A9Q0YT91_HOLLE Tetraspanin HOLleu_34189 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.3 1.0174 -23.723 VFLLLVGIF 0 0 0 0 0 0 0 0 0 0 21.5016 21.5016 0 0 0 0 0 0 A0A9Q0YTI7 A0A9Q0YTI7_HOLLE RNA-binding S4 domain-containing protein HOLleu_31570 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of mitochondrial transcription [GO:1903108] mitochondrion [GO:0005739] RNA binding [GO:0003723] 1 4.5 1.0223 -23.631 LNGKKITKKSK 0 0 0 0 0 0 0 0 0 0 0 0 0 22.7874 22.7874 0 0 0 A0A9Q0YTJ9 A0A9Q0YTJ9_HOLLE PWWP domain-containing protein 2A HOLleu_33360 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chromocenter [GO:0010369]; nucleus [GO:0005634] chromatin binding [GO:0003682] 2 1.9 0.99927 -28.756 PLKLRPRQ;PLKLRPRQIL 0 0 0 18.7957 0 19.8227 0 22.0589 22.0589 21.7741 0 0 0 0 0 17.845 0 18.9184 A0A9Q0YTL1 A0A9Q0YTL1_HOLLE Adenosine receptor A2b HOLleu_32109 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled adenosine receptor signaling pathway [GO:0001973] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 2.1 1.0117 -23.777 TGSNDSDD 0 19.8783 19.8783 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YTL3 A0A9Q0YTL3_HOLLE Uncharacterized protein HOLleu_33416 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment of protein localization [GO:0045184]; mitotic cytokinesis [GO:0000281]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] midbody [GO:0030496] 1 3 1.0048 -2.6427 PKIFLFVRI 0 20.7907 20.7907 17.6414 18.9312 18.9312 0 20.7089 20.7089 0 0 0 0 0 0 0 0 17.6857 A0A9Q0YTN0 A0A9Q0YTN0_HOLLE Vacuolar protein sorting-associated protein 13C HOLleu_31744 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) late endosome to vacuole transport [GO:0045324]; mitochondrion organization [GO:0007005]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] extrinsic component of membrane [GO:0019898] 1 0.6 1.0126 -16.819 FTLALKDRSLLPASYVL 0 0 0 0 0 0 0 0 0 21.0997 0 0 0 0 0 0 0 0 A0A9Q0YTQ0 A0A9Q0YTQ0_HOLLE "Adrenodoxin, mitochondrial" HOLleu_31870 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) P450-containing electron transport chain [GO:0140647] cytosol [GO:0005829] "2 iron, 2 sulfur cluster binding [GO:0051537]" 1 4.1 1.0121 -23.777 GASDEEMD 22.5278 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YTY9 A0A9Q0YTY9_HOLLE SMC5-SMC6 complex localization factor protein 2 HOLleu_33905 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA damage response [GO:0006974]; positive regulation of double-strand break repair [GO:2000781]; protein localization to site of double-strand break [GO:1990166] nucleus [GO:0005634]; site of double-strand break [GO:0035861] 1 0.7 1.0162 -22.715 QNSEGSAGLEIEET 0 20.6775 20.6775 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YU02 A0A9Q0YU02_HOLLE PHD-type domain-containing protein HOLleu_33988 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 5.4 0.99788 -0.31124 RGKRKMNKKKGKGKGKGKKSKRVQ 0 0 0 0 0 0 0 0 0 21.6372 21.3501 21.3501 0 0 0 0 0 0 A0A9Q0YU65 A0A9Q0YU65_HOLLE Elongin-A HOLleu_31302 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) transcription elongation by RNA polymerase II [GO:0006368] elongin complex [GO:0070449] 2 2.5 1.0103 -7.6144 KSLKLMKRV;PIKQRTDHKDSQP 22.7472 25.2138 25.2138 0 0 0 19.7934 0 0 0 0 0 19.7714 19.8244 19.8244 0 0 0 A0A9Q0YU76 A0A9Q0YU76_HOLLE "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" HOLleu_31435 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2 1.0198 -21.924 EPTCQASFCDTPNPD 0 19.5866 19.5866 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q0YUE9 A0A9Q0YUE9_HOLLE Complement factor H HOLleu_31962 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4.5 1.0264 -23.699 CASDQCELDDE;SGGSWDPD 0 20.5513 20.5513 0 0 0 0 21.2392 21.2392 20.8973 0 0 0 0 0 0 0 0 A0A9Q1B8E9 A0A9Q1B8E9_HOLLE Protein stu1 HOLleu_45267 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10 1.0046 -2.5328 YEDESEDESEDECEDESEDECE 0 0 0 0 0 0 21.6278 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1B8T2 A0A9Q1B8T2_HOLLE Transposase domain-containing protein HOLleu_44057 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0065 -2.6427 PLKARLPSR 20.2939 21.5998 21.5998 17.8218 18.4407 18.4407 0 0 0 22.4864 21.5742 21.5742 0 0 0 0 0 0 A0A9Q1B8Y2 A0A9Q1B8Y2_HOLLE Uncharacterized protein HOLleu_43728 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.8 1.0112 -12.327 NPSCYWNFMDSFET;PSCYWNFMDSFET 26.4238 0 0 0 0 0 0 0 0 22.1756 0 0 0 0 0 0 0 0 A0A9Q1B912 A0A9Q1B912_HOLLE Uncharacterized protein HOLleu_43478 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 11.1 0.95575 -0.068637 CSGSGGGC;VGGGGSGP 22.7469 23.3314 23.3314 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1B938 A0A9Q1B938_HOLLE C2H2-type domain-containing protein HOLleu_45243 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.2 1.0232 -23.675 DAYMYDYCDG 0 0 0 0 0 0 0 0 0 0 0 0 0 17.7959 17.7959 0 0 0 A0A9Q1B999 A0A9Q1B999_HOLLE CCHC-type domain-containing protein HOLleu_42618 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 4.7 1.0254 -5.5496 ECDEDVAMEED 0 0 0 0 0 0 0 0 0 0 25.0186 25.0186 0 0 0 0 0 0 A0A9Q1B9N2 A0A9Q1B9N2_HOLLE A disintegrin and metalloproteinase with thrombospondin motifs 20 HOLleu_41431 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 0.8 0.96757 -0.15169 WGSCSQTCGDG 0 0 0 21.7645 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1B9N6 A0A9Q1B9N6_HOLLE Membrane frizzled-related protein HOLleu_43578 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) acrosome reaction [GO:0007340] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] 1 1.4 1.0014 -4.979 HCVDGEDEDN 22.8781 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1B9Q9 A0A9Q1B9Q9_HOLLE Zinc finger PHD-type domain-containing protein HOLleu_43399 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 0.99727 -1.3651 KVRSLRIFL 20.5756 24.7482 24.7482 21.921 23.1447 23.1447 21.4673 0 0 25.4401 25.5684 25.5684 21.7471 22.2961 22.2961 0 0 0 A0A9Q1B9S7 A0A9Q1B9S7_HOLLE V(D)J recombination activating protein 1 HOLleu_43231 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 1.3 1.026 -23.723 RTKTLRLFL 0 0 0 0 0 0 0 0 0 0 19.1163 19.1163 0 0 0 0 0 0 A0A9Q1B9Y6 A0A9Q1B9Y6_HOLLE Flavin-containing monooxygenase (EC 1.-.-.-) HOLleu_41939 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" 1 2.3 1.0227 -23.675 LKGHIRFKTT 0 0 0 0 0 0 0 0 0 0 0 0 0 17.6632 17.6632 0 0 0 A0A9Q1BA10 A0A9Q1BA10_HOLLE DNA-directed DNA polymerase (EC 2.7.7.7) HOLleu_42671 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA replication [GO:0006260] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166] 1 0.9 1.007 -6.2493 TYDSTNFQNDDDD 21.6527 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BA73 A0A9Q1BA73_HOLLE Protein NLRC5 HOLleu_42333 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.004 -2.6427 VWMKGKLRK 0 19.8618 19.8618 0 0 0 19.3031 19.227 19.227 22.0646 20.7299 20.7299 0 0 0 0 0 0 A0A9Q1BA74 A0A9Q1BA74_HOLLE SWIM-type domain-containing protein HOLleu_44425 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion binding [GO:0008270] 1 5 1.0238 -23.631 KFKFKKPPRTT 0 0 0 0 0 0 0 0 0 0 0 0 0 22.2815 22.2815 0 0 0 A0A9Q1BA82 A0A9Q1BA82_HOLLE Fibropellin-1 HOLleu_42278 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Notch signaling pathway [GO:0007219] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 1 2.7 1.0098 -6.0118 DLDECDSGPCMN 21.3036 22.2177 22.2177 0 0 0 0 0 0 21.5669 22.1643 22.1643 17.7174 18.2724 18.2724 0 0 0 A0A9Q1BAB3 A0A9Q1BAB3_HOLLE GIY-YIG domain-containing protein HOLleu_42097 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.9 1.0055 -23.777 VGKRRTAN 0 0 0 0 0 0 0 0 0 21.5799 0 0 0 19.3682 19.3682 0 0 0 A0A9Q1BAC8 A0A9Q1BAC8_HOLLE Arylsulfatase B HOLleu_44128 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sulfuric ester hydrolase activity [GO:0008484] 1 1.5 0.91818 -0.068637 GGQIHEGG 0 0 0 0 0 0 0 0 0 24.2325 0 0 0 0 0 0 0 0 A0A9Q1BAC9 A0A9Q1BAC9_HOLLE receptor protein-tyrosine kinase (EC 2.7.10.1) HOLleu_40999 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ERBB signaling pathway [GO:0038127]; negative regulation of apoptotic process [GO:0043066]; neurogenesis [GO:0022008]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284] basal plasma membrane [GO:0009925]; receptor complex [GO:0043235] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 2 1.5 1.0125 -11.057 CAAGCFDSSPTGCH;CSHEDYRCHE 0 26.2161 26.2161 16.3669 16.9724 16.9724 0 21.881 21.881 22.5816 0 0 0 0 0 0 0 17.2183 A0A9Q1BAE2 A0A9Q1BAE2_HOLLE Sterile alpha motif domain-containing protein 3 HOLleu_44543 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 1.0109 -6.0118 ENEHVFDYCDSA 0 0 0 21.3506 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BAE7 A0A9Q1BAE7_HOLLE Low-density lipoprotein receptor-related protein 1 HOLleu_44525 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 1 17.3 1.0121 -2.2078 NTMCITECDLCDGYYIDCADGSD 0 0 0 0 0 0 23.3156 22.459 22.459 0 0 0 0 0 0 16.7823 0 0 A0A9Q1BAG5 A0A9Q1BAG5_HOLLE ATP-dependent DNA helicase (EC 3.6.4.12) HOLleu_43895 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] 2 1.1 1.0068 -6.6479 PLGIFQDTYS;QDGNESEDGNEDE 18.7958 0 0 0 0 0 0 0 0 0 0 0 25.4636 24.9945 24.9945 0 0 0 A0A9Q1BAG6 A0A9Q1BAG6_HOLLE ABC transmembrane type-1 domain-containing protein HOLleu_44445 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2 0.91892 -0.068637 VFSYCCFS 20.4575 21.0369 21.0369 0 0 0 0 0 0 20.9604 20.9869 20.9869 0 0 0 0 0 0 A0A9Q1BAH4 A0A9Q1BAH4_HOLLE Immunoglobulin subtype domain-containing protein HOLleu_40410 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.2 1.0007 -4.979 TPLIVTISIL 0 0 0 21.5044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BAI1 A0A9Q1BAI1_HOLLE LINE-1 reverse transcriptase-like HOLleu_43847 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion involved in heart morphogenesis [GO:0061343]; larval heart development [GO:0007508] extracellular matrix [GO:0031012] RNA-directed DNA polymerase activity [GO:0003964] 1 1.2 1.019 -17.224 KKANWEIMINDYKDSD 0 0 0 0 0 0 0 0 0 0 0 0 0 17.1188 17.1188 0 0 0 A0A9Q1BAI8 A0A9Q1BAI8_HOLLE TBCC domain-containing protein 1 HOLleu_45112 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) maintenance of centrosome location [GO:0051661]; maintenance of Golgi location [GO:0051684] spindle pole centrosome [GO:0031616] 1 7.5 1.0115 -6.0118 ILTPLRPLILGG 0 0 0 0 0 0 0 23.7843 23.7843 0 0 0 0 0 0 25.4183 24.9743 24.9743 A0A9Q1BAL4 A0A9Q1BAL4_HOLLE Ryncolin-4 HOLleu_41281 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 3.8 1.0088 -2.7235 SCDDPTGVRHCHENCEGHNEA 0 23.9213 23.9213 0 0 0 0 0 0 0 21.5976 21.5976 0 18.428 18.428 0 0 0 A0A9Q1BAL9 A0A9Q1BAL9_HOLLE Uncharacterized protein HOLleu_43680 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.8 1.0161 -22.715 FSFEAGERNIRFIL 0 0 0 0 0 0 0 0 0 0 0 0 0 20.3806 20.3806 0 0 0 A0A9Q1BAN7 A0A9Q1BAN7_HOLLE Protein pinocchio HOLleu_40655 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.5 1.02 -17.224 SSSWYDGQFSTQCQEC 0 0 0 0 0 0 20.8552 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BAR7 A0A9Q1BAR7_HOLLE Transmembrane 9 superfamily member HOLleu_40775 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein localization to membrane [GO:0072657] autophagosome membrane [GO:0000421] 1 1.9 1.0249 -5.5496 LLIGFVIIILM 0 0 0 0 0 0 0 0 0 0 0 0 22.4549 0 0 0 0 0 A0A9Q1BAU3 A0A9Q1BAU3_HOLLE SWIM-type domain-containing protein HOLleu_43823 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion binding [GO:0008270] 1 2 1.0172 -17.224 WNYSGEMMFVDSSGNM 20.4205 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BAU4 A0A9Q1BAU4_HOLLE Inactive dipeptidyl peptidase 10 HOLleu_41615 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] plasma membrane [GO:0005886] dipeptidyl-peptidase activity [GO:0008239]; serine-type peptidase activity [GO:0008236] 1 1.4 1.0276 -23.631 YFYKYVVWRNR 0 0 0 17.723 18.5373 18.5373 20.0483 19.985 19.985 22.0594 0 0 0 0 0 16.7091 0 17.0547 A0A9Q1BB03 A0A9Q1BB03_HOLLE Uncharacterized protein HOLleu_43555 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.8 1.0262 -23.631 PDWDCEDLTDS 0 17.6886 17.6886 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BB23 A0A9Q1BB23_HOLLE Collectin-12 HOLleu_41958 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.8 0.77419 -0.068637 EDEAGSWF 19.9617 21.6968 21.6968 0 0 0 0 0 0 23.4408 21.5683 21.5683 0 0 0 0 0 0 A0A9Q1BB27 A0A9Q1BB27_HOLLE MAM and LDL-receptor class A domain-containing protein 2 HOLleu_38521 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 1.1 1.0077 -6.0804 AGDGFFGD;HLDCCDGTDESE 28.6301 24.6805 24.6805 0 0 0 0 0 0 0 0 0 22.0955 22.9914 22.9914 0 0 0 A0A9Q1BB67 A0A9Q1BB67_HOLLE RING-type E3 ubiquitin transferase (EC 2.3.2.27) HOLleu_38686 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] 1 0.8 1.0027 -23.777 GNQDGGDG 0 0 0 0 0 0 0 21.0368 21.0368 0 0 0 0 0 0 0 0 0 A0A9Q1BB92 A0A9Q1BB92_HOLLE Uncharacterized protein HOLleu_42606 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 6.4 1.0167 -17.171 KKLLVGRNSRKVILLGVF;SRKVILLGVFL 0 25.0337 25.0337 0 0 0 0 22.9411 22.9411 0 25.0249 25.0249 0 16.8781 16.8781 0 0 0 A0A9Q1BBA2 A0A9Q1BBA2_HOLLE ATP-dependent DNA helicase (EC 3.6.4.12) HOLleu_39916 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial genome maintenance [GO:0000002]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723] mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596] ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697] 1 2.2 0.99706 -4.7869 GDCFLECIDMCVCCDSCD 0 0 0 0 0 0 21.7571 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BBE4 A0A9Q1BBE4_HOLLE BEN domain-containing protein HOLleu_38972 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA binding [GO:0003677] 1 4.2 1.0134 -5.7538 HFSPMNHNGEFDEDE 22.2736 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BBM1 A0A9Q1BBM1_HOLLE Transmembrane protein 45B HOLleu_41107 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 8.2 0.98372 -0.20876 HYIWKMFRLIPWEGCIFFFSGLVG 0 21.4313 21.4313 0 0 0 0 19.1834 19.1834 0 0 0 0 0 0 0 0 0 A0A9Q1BBN0 A0A9Q1BBN0_HOLLE Uncharacterized protein HOLleu_42363 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.2 1.0192 -23.723 GESGSGSPD 0 0 0 0 0 0 0 19.7017 19.7017 0 0 0 0 0 0 0 0 0 A0A9Q1BBN2 A0A9Q1BBN2_HOLLE Peptidoglycan recognition protein 3 HOLleu_41147 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; peptidoglycan catabolic process [GO:0009253] membrane [GO:0016020] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270] 1 2 1.0073 -2.6427 NECFDFDTC 20.068 21.5744 21.5744 0 0 0 0 0 0 0 19.9802 19.9802 0 0 0 0 0 0 A0A9Q1BBN6 A0A9Q1BBN6_HOLLE Uncharacterized protein HOLleu_39280 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] sulfotransferase activity [GO:0008146] 1 1.5 0.9373 -0.068637 GGGWMSDY 0 23.2707 23.2707 0 0 0 0 0 0 22.0589 21.0933 21.0933 0 0 0 0 0 0 A0A9Q1BBQ0 A0A9Q1BBQ0_HOLLE PiggyBac transposable element-derived protein 4 HOLleu_40444 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 1.0121 -5.7538 TPPYPPGPKCNLLPN 0 24.4135 24.4135 0 18.1041 18.1041 0 0 0 0 0 0 0 19.1276 19.1276 0 0 15.6745 A0A9Q1BBT0 A0A9Q1BBT0_HOLLE Cilia- and flagella-associated protein 65 HOLleu_41362 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sperm axoneme assembly [GO:0007288] cytoplasm [GO:0005737]; sperm flagellum [GO:0036126] 1 0.7 1.0053 -6.2493 HTDAEYQQSLMEE 0 0 0 0 0 0 21.6467 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BBX4 A0A9Q1BBX4_HOLLE C2H2-type domain-containing protein HOLleu_41613 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 1 1.6 1.0225 -5.5496 DADNDDDEEET 0 0 0 0 0 0 0 0 0 22.3267 0 0 0 0 0 0 0 0 A0A9Q1BBX9 A0A9Q1BBX9_HOLLE Uncharacterized protein HOLleu_41189 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 11 1.0248 -23.723 RKSVLFSND 0 0 0 0 0 0 20.928 0 0 23.3827 0 0 0 0 0 0 0 0 A0A9Q1BBY2 A0A9Q1BBY2_HOLLE "L-cysteine desulfhydrase, chloroplastic" HOLleu_41649 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.8 1.0008 -23.777 VPKKLIIR 0 0 0 0 0 0 0 14.7526 14.7526 16.2267 0 0 0 14.8509 14.8509 0 0 0 A0A9Q1BC14 A0A9Q1BC14_HOLLE Tetraspanin HOLleu_40924 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.6 0.77143 -0.068637 VIPPQVTT 0 0 0 0 0 0 20.331 0 0 22.3423 21.5512 21.5512 0 0 0 0 0 0 A0A9Q1BC22 A0A9Q1BC22_HOLLE A disintegrin and metalloproteinase with thrombospondin motifs 20 HOLleu_41363 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 0.7 1.0146 -6.0118 CGNGQWCMSGSC 24.4173 25.0792 25.0792 0 0 0 0 0 0 26.4776 0 0 0 0 0 0 0 0 A0A9Q1BC36 A0A9Q1BC36_HOLLE Mucin-3A HOLleu_41863 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 1.0175 -6.0779 YYMDDMGEEGYLCR 0 0 0 0 0 0 22.207 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BC86 A0A9Q1BC86_HOLLE von Willebrand factor A domain-containing protein 5B1 HOLleu_38485 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 0.90678 -0.068637 PLKLHLPS 20.7646 22.473 22.473 0 19.5926 19.5926 21.315 21.676 21.676 0 0 0 0 0 0 0 18.5689 18.5689 A0A9Q1BC90 A0A9Q1BC90_HOLLE Integral membrane protein 2 HOLleu_39700 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.8 1.022 -23.675 CSCSFPCCVY 0 18.9366 18.9366 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BC92 A0A9Q1BC92_HOLLE Cubilin HOLleu_41711 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] signaling receptor activity [GO:0038023] 2 0.4 1.0088 -7.1188 TVYDDSCLDQTYTDT;WVDCMDFND 21.5054 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCD4 A0A9Q1BCD4_HOLLE Collagen alpha-1(XXVII) chain B HOLleu_41880 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] 1 1.1 1.0048 -6.2493 AGRDGTNCSCSEG 0 21.5821 21.5821 0 0 0 0 0 0 0 24.8356 24.8356 0 0 0 0 0 0 A0A9Q1BCD8 A0A9Q1BCD8_HOLLE Ribosome biogenesis protein BMS1-like HOLleu_38642 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; U3 snoRNA binding [GO:0034511] 1 0.7 1.0191 -23.723 SDDDNDDDD 18.3007 19.6735 19.6735 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCE1 A0A9Q1BCE1_HOLLE C2H2-type domain-containing protein HOLleu_41018 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 1.0019 -23.777 SHSGAGGT 0 0 0 0 16.7342 0 0 0 0 0 17.0873 17.0873 0 0 0 0 0 0 A0A9Q1BCF4 A0A9Q1BCF4_HOLLE Endonuclease/exonuclease/phosphatase domain-containing protein HOLleu_41957 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) catalytic activity [GO:0003824]; metal ion binding [GO:0046872] 1 3.3 1.0154 -16.819 EFLKFKIRSLSINYSKK 0 0 0 0 0 0 0 0 0 0 20.0646 20.0646 0 0 0 0 0 0 A0A9Q1BCG1 A0A9Q1BCG1_HOLLE Neurotrypsin HOLleu_37602 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "blood coagulation [GO:0007596]; regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; zymogen activation [GO:0031638]" extracellular space [GO:0005615]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791] fucose binding [GO:0042806]; serine-type endopeptidase activity [GO:0004252] 1 0.7 1.0187 -23.723 DPNDEDHWE 0 26.1598 26.1598 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCH1 A0A9Q1BCH1_HOLLE Solute carrier organic anion transporter family member HOLleu_40020 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] 1 1.4 1.0073 -2.6427 CHAGCTQDF 0 23.7793 23.7793 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCK2 A0A9Q1BCK2_HOLLE RNA-directed DNA polymerase from mobile element jockey HOLleu_38855 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; methyltransferase activity [GO:0008168]; RNA-directed DNA polymerase activity [GO:0003964] 1 1.3 0.94118 -0.068637 GKATSPDG 23.6601 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCN9 A0A9Q1BCN9_HOLLE BRCT domain-containing protein HOLleu_41495 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.0147 -6.0118 KIHKGRVRRKLP 0 0 0 0 0 0 0 0 0 0 23.1904 23.1904 20.8657 0 0 0 0 0 A0A9Q1BCQ3 A0A9Q1BCQ3_HOLLE Low-density lipoprotein receptor-related protein 2 HOLleu_41565 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) receptor-mediated endocytosis [GO:0006898] apical plasma membrane [GO:0016324]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; hormone binding [GO:0042562] 2 0.9 1.0053 -23.845 DHTDEADC;NGRSDCED 20.8715 22.1169 22.1169 0 0 0 0 0 0 21.2054 20.4926 20.4926 0 0 0 0 0 0 A0A9Q1BCQ6 A0A9Q1BCQ6_HOLLE ER membrane protein complex subunit 1 HOLleu_39063 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein folding in endoplasmic reticulum [GO:0034975] EMC complex [GO:0072546] 1 0.8 1.0034 -23.777 YFVHLKKK 0 0 0 0 0 0 0 18.294 18.294 0 0 0 0 0 0 0 0 0 A0A9Q1BCQ9 A0A9Q1BCQ9_HOLLE Protein eyes shut-like HOLleu_40040 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 3 0.9 1.0068 -6.5451 CMEGWTGD;CNCPFRFGGNFCEY;PTCEEIEGNC 23.5784 0 0 0 0 0 0 21.3182 21.3182 0 0 0 0 0 0 0 0 0 A0A9Q1BCR2 A0A9Q1BCR2_HOLLE Uncharacterized protein HOLleu_41612 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 0.93333 -0.068637 IKDNQINN 22.0823 0 0 19.1952 19.5644 19.5644 0 0 0 0 0 0 0 0 0 18.2422 0 0 A0A9Q1BCR3 A0A9Q1BCR3_HOLLE Vinexin HOLleu_37918 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] 1 0.6 1.0019 -23.777 PNGGFTMS 0 18.1412 18.1412 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCS1 A0A9Q1BCS1_HOLLE G-protein coupled receptors family 1 profile domain-containing protein HOLleu_41669 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled adenosine receptor signaling pathway [GO:0001973] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 3.1 1.0226 -23.723 VSLKKYYVI 0 0 0 0 0 0 0 0 0 0 0 0 17.7197 0 0 0 0 0 A0A9Q1BCS6 A0A9Q1BCS6_HOLLE Phospholipase A2 (EC 3.1.1.4) HOLleu_38005 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; phospholipase A2 activity [GO:0004623] 1 6.1 1.0224 -23.675 CCSEHDQCYE 0 0 0 22.5078 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCS8 A0A9Q1BCS8_HOLLE Uncharacterized protein HOLleu_39197 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 9.3 1.0151 -6.0779 SPVIIVVPVIAVIG 0 0 0 0 21.776 21.776 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCU3 A0A9Q1BCU3_HOLLE Nucleolar transcription factor 1 HOLleu_40079 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] DNA binding [GO:0003677] 1 2.8 1.0166 -5.8824 SDSDSSDDDDDDDEDDDDDDD 0 0 0 0 0 0 0 0 0 0 0 0 0 18.3817 18.3817 0 0 0 A0A9Q1BCV1 A0A9Q1BCV1_HOLLE LINE-1 retrotransposable element ORF2 protein HOLleu_39279 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4 1.0014 -4.979 NVCCAWGTMN 0 21.2671 21.2671 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BCW2 A0A9Q1BCW2_HOLLE Heterogeneous nuclear ribonucleoprotein H2 HOLleu_38154 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] 3 4.6 1.0057 -23.845 GGYGGYGG;GYGGGGGA;YGGYGGGG 0 0 0 0 0 0 0 21.3802 21.3802 0 0 0 0 17.618 17.618 0 0 0 A0A9Q1BCZ5 A0A9Q1BCZ5_HOLLE Twitchin HOLleu_42023 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] 4 0.1 0.99747 -34.202 QDGQHYSFEYGDDN;REPAGHPS;RPPGVAPH;VTVAALEP 21.8801 0 0 0 16.7803 16.7803 0 0 0 0 20.5687 20.5687 0 0 0 0 0 0 A0A9Q1BD35 A0A9Q1BD35_HOLLE Deleted in malignant brain tumors 1 protein (Hensin) HOLleu_37091 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; protein transport [GO:0015031]; proteolysis [GO:0006508] membrane [GO:0016020] serine-type peptidase activity [GO:0008236] 5 2.6 1.0172 -16.973 CDDWCGLTGECCSYCQRLNC;CHCEYWCA;GWCHCSYWC;NCTFEYDTCGYYQRNDDDFD;NNECCYYCPGGT 25.5487 23.5833 23.5833 0 18.3513 0 0 0 0 26.1594 23.9633 23.9633 23.5238 22.9728 22.9728 0 0 0 A0A9Q1BD41 A0A9Q1BD41_HOLLE Octopamine receptor HOLleu_40345 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] 2 9.3 1.0149 -21.993 LIIPLEIHYWLYEFN;NFGVKFTCSRIKETESTRDRNRLNE 0 22.3395 22.3395 0 0 0 0 18.5751 18.5751 0 19.8368 19.8368 0 0 0 0 0 0 A0A9Q1BD65 A0A9Q1BD65_HOLLE E3 ubiquitin-protein ligase UBR5 HOLleu_40443 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] 2 1 0.99707 -4.9626 ILRKKLLLAI;NEAEEESENEFEEDEETME 0 0 0 0 0 0 22.2906 22.0837 22.0837 0 0 0 0 0 0 0 0 0 A0A9Q1BD98 A0A9Q1BD98_HOLLE 60S acidic ribosomal protein P0 HOLleu_40976 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasmic translation [GO:0002181]; ribosome biogenesis [GO:0042254] cytosolic large ribosomal subunit [GO:0022625] large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] 1 2.5 0.92593 -0.068637 LRGHGIVL 0 20.2155 20.2155 20.194 0 0 20.5396 0 0 23.1211 0 0 21.7207 19.8822 19.8822 18.1121 0 0 A0A9Q1BDA6 A0A9Q1BDA6_HOLLE Lipid droplet-associated hydrolase (Lipid droplet-associated serine hydrolase) HOLleu_40737 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lipid storage [GO:0019915] lipid droplet [GO:0005811] lipase activity [GO:0016298] 1 3.7 1.0137 -6.0118 DKWCPIEFYEDM 21.6626 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BDF5 A0A9Q1BDF5_HOLLE Lysosomal amino acid transporter 1-like HOLleu_38517 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.5 1.0039 -23.777 PEMYDGDM 0 0 0 0 0 0 0 0 0 17.8084 0 0 0 0 0 0 0 0 A0A9Q1BDG2 A0A9Q1BDG2_HOLLE Fibulin-1 HOLleu_37600 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion import across plasma membrane [GO:0098703]; cell communication [GO:0007154] axon [GO:0030424]; postsynapse [GO:0098794]; sarcolemma [GO:0042383] calcium ion binding [GO:0005509]; calcium:sodium antiporter activity [GO:0005432] 2 0.5 1.0073 -6.3441 DVTTEGANDY;VTCNIMDND 0 0 0 0 0 0 0 20.7398 20.7398 0 0 0 0 0 0 0 0 0 A0A9Q1BDM4 A0A9Q1BDM4_HOLLE Tesmin/TSO1-like CXC domain-containing protein HOLleu_37802 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1.2 1.0034 -25.04 HVVRRSDRYW;VRDMLPYFA 23.135 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BDN2 A0A9Q1BDN2_HOLLE WAP four-disulfide core domain protein 1 HOLleu_38835 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of cell growth [GO:0001558] extracellular space [GO:0005615] peptidase inhibitor activity [GO:0030414] 1 6.6 1.0119 -6.0118 KCCYNGCKNTCM 0 23.9071 23.9071 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BDN9 A0A9Q1BDN9_HOLLE Neurotrypsin HOLleu_37859 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.6 0.72093 -0.068637 YCHGTFYS 0 0 0 0 0 0 22.4202 21.9958 21.9958 0 0 0 0 0 0 0 0 0 A0A9Q1BDQ2 A0A9Q1BDQ2_HOLLE Acetylcholine receptor subunit alpha-type acr-16 HOLleu_37917 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; neuron projection [GO:0043005]; synapse [GO:0045202] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] 1 3.3 1.0195 -17.224 EFYYSCCPEPYPDVEY 0 19.2585 19.2585 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BDS2 A0A9Q1BDS2_HOLLE RNA-directed DNA polymerase (EC 2.7.7.49) HOLleu_36568 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 0.6 0.91589 -0.068637 WDDECMDE 20.2334 20.7014 20.7014 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BDS7 A0A9Q1BDS7_HOLLE Hyalin HOLleu_40716 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.3 1.0007 -4.979 SCPENVTGST 25.1685 25.9224 25.9224 0 0 0 0 0 0 0 16.8793 16.8793 19.9934 20.1529 20.1529 0 0 0 A0A9Q1BDS9 A0A9Q1BDS9_HOLLE Protocadherin Fat 4 HOLleu_38020 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] 1 0.5 1.0054 -5.2234 SPSYVYAGATDDDEMDT 20.065 24.7102 24.7102 0 0 0 0 0 0 21.5084 22.6629 22.6629 19.8331 0 0 0 0 0 A0A9Q1BDT8 A0A9Q1BDT8_HOLLE Carbohydrate sulfotransferase (EC 2.8.2.-) HOLleu_36726 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate biosynthetic process [GO:0016051]; proteoglycan biosynthetic process [GO:0030166] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] 1 2.5 1.0248 -23.675 YFHKLPEEKR 0 24.2849 24.2849 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BDU7 A0A9Q1BDU7_HOLLE Cadherin EGF LAG seven-pass G-type receptor 1 HOLleu_40752 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1.5 1.0272 -23.442 NLIILILSIVFT 18.8272 20.9225 20.9225 17.5891 0 0 0 0 0 0 0 0 0 18.9503 18.9503 16.3345 0 0 A0A9Q1BDU9 A0A9Q1BDU9_HOLLE Neprilysin-1 HOLleu_39044 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein processing [GO:0016485] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 2.5 0.99851 -4.564 ESMNTEADPCEDFYEYACG 23.5005 24.0026 24.0026 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BDW2 A0A9Q1BDW2_HOLLE Kielin/chordin-like protein HOLleu_40824 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 2 5.8 0.9978 -4.9586 AYVRSTMIKIKFNGKSKLKLEKKKP;NCVCQNGTFDCFTEVCDT 19.496 0 0 0 0 0 0 0 0 24.8124 22.8564 22.8564 0 0 0 0 0 0 A0A9Q1BE24 A0A9Q1BE24_HOLLE C2H2-type domain-containing protein HOLleu_34264 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 1.1 1.0163 -6.0779 CCQFCGKQLSSMEC 0 24.1021 24.1021 0 0 0 0 0 0 24.112 23.2797 23.2797 0 0 0 0 0 0 A0A9Q1BE25 A0A9Q1BE25_HOLLE Uncharacterized protein HOLleu_39374 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 20.3 1.0064 -6.2493 RGCYCCEGGQCIF 0 23.6145 23.6145 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BE37 A0A9Q1BE37_HOLLE Basement membrane-specific heparan sulfate proteoglycan core protein HOLleu_39432 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; basement membrane [GO:0005604]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509] 7 2.7 0.99575 -67.472 CDGDDDCGDGSD;DNDYDCIDRSD;ECFCNGHSDLCDPETGVCQDC;IPCECNGYSNECDAE;VTIGNSVTFECRA;WLCDGDDDCGDGSDEENCPT;YLREGNYYWS 0 22.9034 22.9034 0 0 0 0 20.722 19.7787 22.0164 20.5277 20.5277 0 0 0 0 0 0 A0A9Q1BE45 A0A9Q1BE45_HOLLE MDS1 and EVI1 complex locus protein HOLleu_38461 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA-binding transcription factor activity [GO:0003700] 1 0.9 1.016 -2.6427 GEFQCPYCP 0 0 0 0 0 0 21.7892 15.6229 15.6229 0 0 0 0 0 0 0 0 0 A0A9Q1BE73 A0A9Q1BE73_HOLLE Corticotropin-releasing factor receptor 2 HOLleu_34445 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528] 1 2.6 1.0161 -23.027 VRVPLILAIFLNT 0 0 0 0 0 0 0 17.5437 17.5437 0 0 0 0 0 0 0 0 0 A0A9Q1BE85 A0A9Q1BE85_HOLLE arylamine N-acetyltransferase (EC 2.3.1.5) HOLleu_34480 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) arylamine N-acetyltransferase activity [GO:0004060] 2 10.9 0.99932 -5.1507 LLHGNKPVPP;QVLLRYNLRKPMARYHINKYWQMLL 0 0 0 20.4921 0 0 20.7561 21.1359 21.1359 22.6017 22.87 22.87 21.6993 20.2967 20.2967 19.1819 0 0 A0A9Q1BE88 A0A9Q1BE88_HOLLE "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17)" HOLleu_38612 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694] membrane [GO:0016020] 17-alpha-hydroxyprogesterone aldolase activity [GO:0047442]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508] 1 1.5 1.0066 -23.777 MAACSNHF 0 0 0 0 0 0 0 20.4533 20.4533 0 0 0 0 0 0 0 0 0 A0A9Q1BE93 A0A9Q1BE93_HOLLE Transformation/transcription domain-associated protein HOLleu_34520 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281]; phosphorylation [GO:0016310]; regulation of DNA-templated transcription [GO:0006355] NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; SAGA complex [GO:0000124] kinase activity [GO:0016301] 2 0.5 1.0045 -25.201 LVRLMGIF;LYLKLFKLVFGSV 0 0 0 0 0 0 0 20.359 20.359 0 0 0 0 0 0 0 0 0 A0A9Q1BEA8 A0A9Q1BEA8_HOLLE Flavin-containing monooxygenase (EC 1.-.-.-) HOLleu_37148 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" 1 1.5 1.0062 -23.777 RHPRLAWR 0 20.1613 20.1613 0 0 0 0 0 0 19.23 18.98 18.98 0 16.7269 16.7269 0 0 0 A0A9Q1BED3 A0A9Q1BED3_HOLLE Uncharacterized protein HOLleu_36007 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.1 1.0131 -6.0118 SDNTRNSDDNDD 0 23.4107 23.4107 0 0 0 23.7719 23.8314 23.8314 23.5008 23.4726 23.4726 0 0 0 0 0 0 A0A9Q1BEE5 A0A9Q1BEE5_HOLLE Matrix metalloproteinase-17 HOLleu_37284 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] 1 3 1.0178 -16.819 PPVVPPMPTYTPPTTTT 0 23.1484 23.1484 16.9253 17.3971 17.3971 0 19.562 19.562 20.5449 20.2652 20.2652 18.0341 0 0 0 0 0 A0A9Q1BEF4 A0A9Q1BEF4_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_37325 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 2 1.4 1.0193 -23.743 PESCGEGEYN;VHLYISTT 0 22.6745 22.6745 0 0 0 0 0 0 22.9789 0 0 0 19.2612 19.2612 0 0 0 A0A9Q1BEG2 A0A9Q1BEG2_HOLLE Potassium channel subfamily K member 16 HOLleu_37358 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) stabilization of membrane potential [GO:0030322] membrane [GO:0016020] outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] 2 3.3 1.0111 -10.202 SFDNDDGHYS;YSEDESDASEGSSHCST 22.6396 0 0 0 0 0 0 0 0 20.7243 0 0 0 0 0 0 0 0 A0A9Q1BEH4 A0A9Q1BEH4_HOLLE WSC domain-containing protein 2 HOLleu_36175 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sulfotransferase activity [GO:0008146] 1 3.2 0.90625 -0.068637 SRRVLKGG 0 0 0 0 0 0 0 0 0 0 0 0 0 22.0831 22.0831 0 0 0 A0A9Q1BEL4 A0A9Q1BEL4_HOLLE Uncharacterized protein HOLleu_37561 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 11.2 1.0273 -23.631 DCSGCDWSSWK 0 19.9661 19.9661 0 0 0 0 0 0 0 18.4718 18.4718 0 0 0 0 0 0 A0A9Q1BEM2 A0A9Q1BEM2_HOLLE Formin-binding protein 4 HOLleu_36372 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.7 1.0119 -5.5027 EEEESSKEEDREEDDD 0 0 0 0 0 0 22.8086 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BEM4 A0A9Q1BEM4_HOLLE Hemicentin-1 HOLleu_37598 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion import across plasma membrane [GO:0098703]; cell communication [GO:0007154] axon [GO:0030424]; postsynapse [GO:0098794]; sarcolemma [GO:0042383] calcium ion binding [GO:0005509]; calcium:sodium antiporter activity [GO:0005432] 1 0.5 1.0027 -23.777 FYHCKCME 0 0 0 0 0 0 0 0 0 19.7665 0 0 0 17.8226 17.8226 0 0 0 A0A9Q1BEM8 A0A9Q1BEM8_HOLLE Sacsin HOLleu_36395 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.2 1.0032 -2.6427 TMITEENCN 21.8863 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BEM9 A0A9Q1BEM9_HOLLE Polycystin-2 HOLleu_37616 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) detection of mechanical stimulus [GO:0050982] cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509] 1 2.8 0.95844 -0.17167 EGFDMGSEEPDMQENYDEQEDDSSD 0 0 0 0 0 0 0 0 0 0 0 0 21.3927 21.4984 21.4984 0 0 0 A0A9Q1BEP0 A0A9Q1BEP0_HOLLE Cdc42-like HOLleu_39153 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; modification of synaptic structure [GO:0099563]; regulation of filopodium assembly [GO:0051489] dendritic spine [GO:0043197]; membrane-bounded organelle [GO:0043227]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] 1 5.4 0.90722 -0.068637 EPPKLLQK 0 0 0 18.3987 0 0 19.64 20.5987 20.5987 21.903 20.7369 20.7369 0 19.9679 19.9679 0 0 0 A0A9Q1BER3 A0A9Q1BER3_HOLLE Titin HOLleu_37415 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 0.6 1.013 -2.2424 DESGAHTE;TEESPGDG 0 0 0 0 0 0 0 0 0 0 22.6707 22.6707 0 0 0 0 0 0 A0A9Q1BES4 A0A9Q1BES4_HOLLE Cyclin-dependent kinase 5 activator 1 HOLleu_35214 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axon guidance [GO:0007411]; brain development [GO:0007420]; phosphorylation [GO:0016310] cytoplasm [GO:0005737]; growth cone [GO:0030426]; protein kinase 5 complex [GO:0016533] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; kinase activity [GO:0016301]; protein kinase binding [GO:0019901] 1 3.3 1.0068 -6.2493 LDSSCTSSSCSSC 0 24.2082 24.2082 0 0 0 0 0 0 26.9728 0 0 0 0 0 0 0 0 A0A9Q1BEV1 A0A9Q1BEV1_HOLLE Stress-activated protein kinase JNK (EC 2.7.11.24) HOLleu_37898 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; protein serine kinase activity [GO:0106310] 1 1.9 1.0023 -23.777 SGGPGGAP 0 0 0 0 0 0 0 0 0 0 0 0 0 18.8989 18.8989 0 0 0 A0A9Q1BEV4 A0A9Q1BEV4_HOLLE General transcription factor IIH subunit HOLleu_39431 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA-templated transcription [GO:0006351]; nucleotide-excision repair [GO:0006289]; regulation of transcription by RNA polymerase II [GO:0006357] transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] zinc ion binding [GO:0008270] 1 2 0.90816 -0.068637 VSAPHLAR 0 28.6973 28.6973 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BEW5 A0A9Q1BEW5_HOLLE Cation-dependent mannose-6-phosphate receptor HOLleu_35367 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; trans-Golgi network [GO:0005802] 1 5.4 1.0163 -6.0779 NPCYPVTDTDDCKD 21.2776 0 0 0 0 0 0 0 0 0 20.137 20.137 0 0 0 0 0 0 A0A9Q1BEX5 A0A9Q1BEX5_HOLLE Uncharacterized protein HOLleu_38002 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 6.8 1.0092 -2.5328 IIIYYYYYYYYYYYYYYYYYYF 0 0 0 19.4622 0 0 21.9683 0 0 23.0611 22.9933 22.9933 20.1061 20.4744 20.4744 0 0 18.4349 A0A9Q1BEX6 A0A9Q1BEX6_HOLLE Uncharacterized protein HOLleu_37670 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 15.3 1.0094 -5.354 IKKKMLLYL;KKKMLLYLL;VVPATSTT 0 0 0 0 0 0 26.6911 0 0 0 27.4203 27.4203 25.1914 24.7692 24.7692 0 0 0 A0A9Q1BF03 A0A9Q1BF03_HOLLE D-3-phosphoglycerate dehydrogenase HOLleu_35504 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617] 1 3.8 1.0298 -23.442 HTPLIPQTKGLI 0 0 0 0 0 0 0 0 0 0 18.9298 18.9298 0 0 0 0 0 0 A0A9Q1BF05 A0A9Q1BF05_HOLLE Amiloride-sensitive sodium channel subunit gamma HOLleu_37782 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] ligand-gated sodium channel activity [GO:0015280] 1 2 1.0037 -6.2493 FDFSSDWWNAYSY 21.8893 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BF08 A0A9Q1BF08_HOLLE DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) HOLleu_32873 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; RNA polymerase III activity [GO:0001056] 1 0.7 0.91919 -0.068637 QKLKHMVL 0 0 0 18.527 0 0 18.8883 19.8931 19.8931 20.957 0 0 0 0 0 0 0 0 A0A9Q1BF14 A0A9Q1BF14_HOLLE Uncharacterized protein HOLleu_37088 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 21.3 1.0141 -2.2078 PTDHPCYGHWSSASSCSCSAPYY 0 0 0 0 0 0 24.7942 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BF37 A0A9Q1BF37_HOLLE Uncharacterized protein HOLleu_38228 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.3 0.91 -0.068637 DDKGQGHG 0 0 0 0 0 0 0 21.5747 21.5747 0 0 0 20.8899 0 0 0 0 0 A0A9Q1BF46 A0A9Q1BF46_HOLLE cGMP-dependent protein kinase (EC 2.7.11.12) HOLleu_37222 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692] 1 1 0.90099 -0.068637 DMGHGAGA 20.4801 21.1693 21.1693 0 0 0 0 0 0 21.0069 20.2614 20.2614 17.8896 18.3414 18.3414 0 0 0 A0A9Q1BF49 A0A9Q1BF49_HOLLE "Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" HOLleu_37955 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell motility [GO:0048870]; negative regulation of cell population proliferation [GO:0008285]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] cell projection [GO:0042995]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; protein tyrosine phosphatase activity [GO:0004725]" 2 7.9 1.0066 -6.2292 EESTESDIDNSEWESA;KVFSPNLKVTLTFSRG 23.5784 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BF53 A0A9Q1BF53_HOLLE Protein Dok-7 HOLleu_37262 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) neuromuscular junction development [GO:0007528] protein kinase binding [GO:0019901] 1 0.9 1.0047 -23.777 SVRHHHSR 0 17.6776 17.6776 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BF64 A0A9Q1BF64_HOLLE Low-density lipoprotein receptor-related protein 4 HOLleu_37298 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070] membrane [GO:0016020] calcium ion binding [GO:0005509]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] 2 3 1.0033 -27.567 FYNGDCTTWNNC;TDSKAKSVMRCLLNGSNPEI 0 0 0 0 0 0 22.0638 21.8654 21.8654 18.4296 20.2641 20.2641 0 0 0 0 0 0 A0A9Q1BF98 A0A9Q1BF98_HOLLE Fibrinogen-like protein A HOLleu_38134 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 5.1 1.0167 -22.715 DHCYYSNFNGEYEP 0 0 0 0 0 0 0 0 0 21.3899 0 0 0 0 0 0 0 0 A0A9Q1BFD6 A0A9Q1BFD6_HOLLE Calcineurin-like phosphoesterase domain-containing protein HOLleu_33366 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) hydrolase activity [GO:0016787] 1 2.6 0.89216 -0.068637 MDFHHCVW 0 0 0 0 0 0 0 0 0 0 0 0 0 20.9029 20.9029 0 0 0 A0A9Q1BFH6 A0A9Q1BFH6_HOLLE Caprin-1 HOLleu_35618 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] RNA binding [GO:0003723] 1 1.9 1.0088 -6.0779 NTSQMDQSQSVGYN 0 26.7509 26.7509 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BFL0 A0A9Q1BFL0_HOLLE Histone H2B HOLleu_35754 HOLleu_35757 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] 1 7 1.0116 -23.777 KGAKKAAK 0 0 0 0 0 0 20.0217 20.1995 20.1995 0 0 0 0 0 0 0 20.3302 20.3302 A0A9Q1BFL4 A0A9Q1BFL4_HOLLE Neurogenic locus notch-like protein 1 HOLleu_34776 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 2 4.3 1 -5.1754 HCETDIDECAENEQHCEHGASC;QHCEHGASC 0 24.4298 24.4298 0 0 0 22.6848 0 0 25.7155 0 0 0 0 0 0 0 0 A0A9Q1BFL6 A0A9Q1BFL6_HOLLE Zinc finger CCCH domain-containing protein 11A HOLleu_36334 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) poly(A)+ mRNA export from nucleus [GO:0016973] metal ion binding [GO:0046872]; mRNA binding [GO:0003729] 2 2.6 0.99707 -4.8555 GSEGPDQYEDDDDALLNE;MAAQGDDC 19.9349 22.5019 22.5019 0 0 0 0 0 0 22.2171 21.8487 21.8487 16.925 0 0 0 0 0 A0A9Q1BFL8 A0A9Q1BFL8_HOLLE Major vault protein HOLleu_33685 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] 2 2 1.0048 -26.419 PLKLIVVPP;VRKTVLQK 0 0 0 18.6588 19.6183 19.6183 20.1141 20.3218 20.3218 22.5659 21.2374 21.2374 0 0 0 17.5356 21.0035 21.2395 A0A9Q1BFL9 A0A9Q1BFL9_HOLLE Granulin HOLleu_34794 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of inflammatory response [GO:0050727] extracellular region [GO:0005576] 2 1.1 1.0098 -7.8661 CCSDDLHCC;HCCPSGYTCDVSAGTCS 23.851 24.7262 24.7262 0 17.055 17.055 0 0 0 22.5931 22.0213 22.0213 0 17.19 17.19 0 0 0 A0A9Q1BFN6 A0A9Q1BFN6_HOLLE Prominin-1-A HOLleu_33743 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; microvillus [GO:0005902]; prominosome [GO:0071914] cholesterol binding [GO:0015485] 1 1.1 1.0175 -2.6427 TDRECMANC 0 0 0 0 0 0 0 0 0 0 20.6695 20.6695 0 0 0 0 0 0 A0A9Q1BFP3 A0A9Q1BFP3_HOLLE "Protein Skeletor, isoforms D/E" HOLleu_33762 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 1.8 0.99963 -28.702 EDYENFDDY;VYYQCYQHRF 0 22.527 22.527 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BFP8 A0A9Q1BFP8_HOLLE Uncharacterized protein HOLleu_33780 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.8 1.02 -23.723 DCVYENNFY 0 0 0 0 20.5174 20.5174 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BFQ3 A0A9Q1BFQ3_HOLLE Palmitoyltransferase (EC 2.3.1.225) HOLleu_37982 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] 1 2.3 1.0074 -6.2493 QTPMTVLKEGGTR 0 25.11 25.11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BFU1 A0A9Q1BFU1_HOLLE Uncharacterized protein HOLleu_36103 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.9 1.0115 -11.395 GVDMEDDNAVAGDQEETED 0 0 0 19.0654 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BFV0 A0A9Q1BFV0_HOLLE Zinc finger CCHC domain-containing protein 3 HOLleu_36705 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) activation of innate immune response [GO:0002218] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] 1 4.3 1.0067 -5.2234 DNQEMDENTMEQDLEDS 0 0 0 0 0 0 21.9357 22.2358 22.2358 0 0 0 0 0 0 0 0 0 A0A9Q1BFW5 A0A9Q1BFW5_HOLLE Large ribosomal subunit protein eL39 (60S ribosomal protein L39) HOLleu_36759 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] 1 49 0.96094 -0.17167 PQWIRLRTGNTIRYNAKRRHWKRTK 0 0 0 0 0 0 0 22.1829 22.1829 0 0 0 0 0 0 0 0 0 A0A9Q1BFX8 A0A9Q1BFX8_HOLLE Low-density lipoprotein receptor-related protein 6 HOLleu_36279 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070]; endocytosis [GO:0006897] membrane [GO:0016020] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] 1 1 1.0274 -23.027 PCAFNNGYCSGLC 0 0 0 0 0 0 0 0 0 19.6419 18.9702 18.9702 0 0 0 0 0 0 A0A9Q1BG05 A0A9Q1BG05_HOLLE VCBS repeat-containing protein HOLleu_36392 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.3 0 -0.068637 GWCSNDGS 20.2374 21.5897 21.5897 0 0 0 0 0 0 0 19.7101 19.7101 0 0 0 0 0 0 A0A9Q1BG27 A0A9Q1BG27_HOLLE Low-density lipoprotein receptor-related protein 4 HOLleu_36488 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) receptor-mediated endocytosis [GO:0006898] apical plasma membrane [GO:0016324]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; hormone binding [GO:0042562] 2 1.4 1.0064 -24.345 PEDWVCDGDND;QISRKLYWTDAEKDR 0 19.4789 19.4789 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BG49 A0A9Q1BG49_HOLLE Telomere-associated protein RIF1 HOLleu_35467 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell cycle [GO:0007049]; telomere maintenance [GO:0000723] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" 2 0.8 1.0163 -5.5133 PLTKKKIRILKKNKKGKE;QNVPLTKKKIRILKKN 0 0 0 0 0 0 0 0 0 21.034 0 0 0 0 0 0 0 0 A0A9Q1BG99 A0A9Q1BG99_HOLLE Complement factor H HOLleu_31445 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] 2 4.3 1.0192 -23.743 CHDGAWAD;YFYDCICNDT 0 21.6952 21.6952 0 0 0 24.3038 19.4504 19.6339 25.1762 19.7153 19.7153 0 0 0 0 0 0 A0A9Q1BGA5 A0A9Q1BGA5_HOLLE Protein tincar HOLleu_33000 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 4.2 0.99777 -4.7869 GPSDSDQDQGSSNSDTDV 0 25.6967 25.6967 16.3124 17.1961 17.1961 0 21.3933 21.3933 25.6624 0 0 0 0 0 16.0664 0 0 A0A9Q1BGC0 A0A9Q1BGC0_HOLLE Teneurin-a HOLleu_34566 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.4 1.0169 -21.924 HYNSSKTLLLPQNHG 0 24.0711 24.0711 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BGD4 A0A9Q1BGD4_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_34625 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 0.7 1.017 -23.723 TENPENVDE 26.2149 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BGD9 A0A9Q1BGD9_HOLLE Polycystic kidney disease protein 1-like 1 HOLleu_34650 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion transport [GO:0006816] cilium [GO:0005929]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; monoatomic cation channel activity [GO:0005261] 1 0.3 1.0219 -23.631 VVVLDKSISNL 0 0 0 0 0 0 0 0 0 0 0 0 18.8739 18.3188 18.3188 0 0 0 A0A9Q1BGH2 A0A9Q1BGH2_HOLLE Tenascin-R HOLleu_34773 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.9 0.88571 -0.068637 YANECLFE 0 21.1946 21.1946 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BGI7 A0A9Q1BGI7_HOLLE Rho GTPase-activating protein 12 HOLleu_34262 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] cytoplasm [GO:0005737] 1 1.1 1.0239 -23.723 KPKSPTRDF 0 0 0 0 0 0 0 0 0 0 0 0 20.3232 0 0 0 0 0 A0A9Q1BGI9 A0A9Q1BGI9_HOLLE Dentin sialophosphoprotein-like HOLleu_34851 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.9 1.0244 -5.5496 DNDDDGSSEFD 0 0 0 0 0 0 0 0 0 0 24.3203 24.3203 0 0 0 0 0 0 A0A9Q1BGJ3 A0A9Q1BGJ3_HOLLE Midasin HOLleu_36350 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8 0.96524 -0.17167 YGYEDDERQSEEDDVSENSDEGNDS 0 0 0 0 0 0 21.6058 21.407 21.407 0 0 0 0 0 0 18.0396 0 19.2772 A0A9Q1BGM2 A0A9Q1BGM2_HOLLE Attractin-like protein 1 HOLleu_33462 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi apparatus [GO:0005794]; membrane [GO:0016020] 3 5.2 1.0127 -12.103 CNSNCANETNYYTCEDMNCQFYKN;CPNNCTMGDCIN;LNGANCSACECNGHSEYCDPN 0 0 0 0 0 0 0 19.2442 19.2442 19.6789 18.7935 18.7935 22.3199 22.1498 22.1498 0 0 0 A0A9Q1BGU9 A0A9Q1BGU9_HOLLE Methyltransferase-like protein 2-A HOLleu_35383 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) RNA methylation [GO:0001510] tRNA (cytidine-3-)-methyltransferase activity [GO:0052735] 1 1.8 1.0058 -23.777 LKPGGLLL 0 0 0 0 0 0 0 17.3795 17.3795 20.0063 0 0 0 0 0 0 0 0 A0A9Q1BGV1 A0A9Q1BGV1_HOLLE Cytosolic carboxypeptidase 2 HOLleu_36758 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] 1 0.6 1.0262 -5.5496 DGDTCFFAHCY 0 22.2615 22.2615 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BGV3 A0A9Q1BGV3_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_34627 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1.1 1.025 -5.5496 LLMIIVIFLAV 0 0 0 0 0 0 0 0 0 0 0 0 0 22.5167 22.5167 0 0 0 A0A9Q1BH23 A0A9Q1BH23_HOLLE Stress response protein nst1 HOLleu_34049 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.4 1.0257 -23.675 DDYQNCSWFH 0 19.0402 19.0402 0 0 0 0 16.9284 16.9284 20.1824 20.0461 20.0461 0 0 0 0 0 0 A0A9Q1BH24 A0A9Q1BH24_HOLLE Transcriptional repressor NF-X1 HOLleu_34933 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" 1 1.6 1 -4.979 AVEGSDGWMC 0 0 0 0 0 0 0 0 0 0 21.5866 21.5866 0 0 0 0 0 0 A0A9Q1BH25 A0A9Q1BH25_HOLLE Sulfotransferase 1C2A HOLleu_33135 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sulfation [GO:0051923] cytoplasm [GO:0005737] sulfotransferase activity [GO:0008146] 1 2.6 1.0057 -23.777 WNHRNDDH 0 0 0 0 0 0 0 0 0 0 0 0 20.3487 0 0 0 0 0 A0A9Q1BH41 A0A9Q1BH41_HOLLE Cuticle-degrading protease HOLleu_34106 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] 1 2.1 1.005 -23.777 SSMSAQAQ 0 18.6449 18.6449 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BH55 A0A9Q1BH55_HOLLE Large ribosomal subunit protein eL43 (60S ribosomal protein L37a) HOLleu_35090 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] 1 6.6 1.0042 -23.777 TKKVGIVG 0 0 0 0 0 0 0 23.6527 23.6527 0 0 0 0 0 0 0 0 0 A0A9Q1BH63 A0A9Q1BH63_HOLLE Alstrom syndrome protein 1 HOLleu_33341 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) centrosome [GO:0005813]; cytoplasm [GO:0005737] microtubule binding [GO:0008017] 2 0.8 1.0041 -26.419 GSDSDYDVG;PGGSHADG 0 0 0 0 0 0 0 0 0 21.9254 21.3156 21.3156 0 0 0 0 0 0 A0A9Q1BH71 A0A9Q1BH71_HOLLE U5 small nuclear ribonucleoprotein 200 kDa helicase HOLleu_33385 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA processing [GO:0006397] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676] 2 0.7 1.0049 -23.845 HVPALKPK;VDKEKNPI 19.7315 19.1664 19.1664 14.7833 16.709 16.709 17.7778 0 0 21.297 0 0 0 17.5687 17.5687 0 0 15.9992 A0A9Q1BHB9 A0A9Q1BHB9_HOLLE Adenosine receptor A2b HOLleu_31481 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]" dendrite [GO:0030425]; plasma membrane [GO:0005886] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378] 1 2.4 0.92453 -0.068637 ICCCCSGC 23.526 21.9479 21.9479 21.1518 0 20.0528 0 0 0 24.8071 22.9791 22.9791 21.3083 0 0 0 0 0 A0A9Q1BHC8 A0A9Q1BHC8_HOLLE DNA helicase B HOLleu_33681 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) helicase activity [GO:0004386] 2 1.2 1.0056 -2.7113 MCEDRMSEG;SNTEMEET 0 21.8713 21.8713 0 0 0 0 21.2542 21.2542 0 0 0 0 0 0 0 0 0 A0A9Q1BHE5 A0A9Q1BHE5_HOLLE Uncharacterized protein HOLleu_31616 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4.9 1.0077 -8.2501 EEEEEEEEEEEEEGCKDFDQ;EEEEEEEEEEEEGCKDFDQE 22.783 18.6508 18.6508 0 0 0 0 0 0 0 22.4012 22.4012 0 0 0 0 0 0 A0A9Q1BHG0 A0A9Q1BHG0_HOLLE Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) HOLleu_32945 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate metabolic process [GO:0005975]; hemopoiesis [GO:0030097]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610] 1 1.6 1.0227 -23.675 NLKPLNSHYT 0 0 0 0 0 0 19.7547 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BHG3 A0A9Q1BHG3_HOLLE Disintegrin and metalloproteinase domain-containing protein 12 HOLleu_33845 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane protein ectodomain proteolysis [GO:0006509] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 2 1.6 1.0082 -6.0804 FCYEHECI;RTHHCYYHGEVR 0 0 0 0 0 0 22.1664 22.6798 22.6798 0 0 0 0 0 0 0 0 0 A0A9Q1BHK7 A0A9Q1BHK7_HOLLE Sacsin HOLleu_34064 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 0.8 1.0052 -6.4482 NSDPCEDQQTCCS;PLKGRKLFKAK 0 0 0 0 0 0 0 0 0 0 0 0 21.9 22.9248 22.9248 0 0 0 A0A9Q1BHL2 A0A9Q1BHL2_HOLLE Glutathione S-transferase 5 HOLleu_33190 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutathione metabolic process [GO:0006749] glutathione transferase activity [GO:0004364] 1 3.8 1.0046 -23.777 MPALRFLA 0 0 0 0 0 0 0 0 0 0 16.5579 16.5579 0 0 0 0 0 0 A0A9Q1BHL6 A0A9Q1BHL6_HOLLE Disintegrin and metalloproteinase domain-containing protein 12 HOLleu_33210 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane protein ectodomain proteolysis [GO:0006509] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 2.1 1.0111 -10.943 KGEQCDCGSPEDCVNPCCVP 0 0 0 0 0 0 0 20.2106 20.2106 0 0 0 0 0 0 0 0 0 A0A9Q1BHM6 A0A9Q1BHM6_HOLLE HAT C-terminal dimerisation domain-containing protein HOLleu_35246 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.4 1.0257 -23.027 KIPEDWYCCTAEN 21.3692 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BHQ0 A0A9Q1BHQ0_HOLLE G-protein coupled receptor GRL101 HOLleu_32116 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528] 1 1.7 1.012 -10.943 FCDFQCPDECMCTGHVFNCS 0 0 0 0 0 0 0 0 0 20.7313 0 0 0 0 0 0 0 0 A0A9Q1BHQ2 A0A9Q1BHQ2_HOLLE Growth factor receptor-bound protein 14 HOLleu_35360 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627] 1 2.8 0.9985 -4.564 SPPPNSRCIPKPMLERERR 20.7227 0 0 18.4023 19.8617 19.8617 21.2544 20.923 20.923 22.8501 22.8896 22.8896 18.5312 19.7126 19.7126 18.5231 0 18.3888 A0A9Q1BHQ4 A0A9Q1BHQ4_HOLLE Organic cation transporter protein HOLleu_32135 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 1 1.4 1.0054 -23.777 SRRRGTLK 19.3529 18.1383 18.1383 0 0 0 0 0 0 17.4014 15.517 15.517 0 14.6434 14.6434 0 0 0 A0A9Q1BHQ5 A0A9Q1BHQ5_HOLLE Tubulin alpha chain HOLleu_31305 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] 1 4.9 1 -0.068637 MVKCDPRLGKYMACCLLFRGDVVPK 0 20.7289 20.7289 0 0 0 0 0 0 0 0 0 0 18.0191 18.0191 0 0 0 A0A9Q1BHR3 A0A9Q1BHR3_HOLLE SCO-spondin HOLleu_35420 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion [GO:0007155] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 5 1.2 0.99541 -98.51 CNGVNDCGDMSD;DEADCPLPTCAPGEFQC;KCNTCVCNSGMWDCTQDVCQ;NCQNCTCENGH;YTQETSTTEM 17.3901 23.8775 23.8775 0 0 0 0 0 0 20.6835 21.6467 21.6467 0 0 0 0 0 0 A0A9Q1BHS0 A0A9Q1BHS0_HOLLE Attractin HOLleu_33461 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi apparatus [GO:0005794]; membrane [GO:0016020] 1 1.7 1.0063 -2.5328 CPNNCTMGNCINGQCVCDNGYY 0 0 0 0 0 0 0 0 0 22.4289 0 0 0 0 0 0 0 0 A0A9Q1BHS2 A0A9Q1BHS2_HOLLE Triacylglycerol lipase 2 HOLleu_31415 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" 2 1.7 1.0046 -8.4231 CSGQDNMCWDPET;VGALTEIQ 21.8519 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BHT5 A0A9Q1BHT5_HOLLE Bone morphogenetic protein 2 HOLleu_32889 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] 1 1.7 0.97521 -0.068637 GIGEGRTR 22.3363 0 0 0 0 0 0 0 0 23.0784 0 0 0 19.0649 19.0649 0 0 0 A0A9Q1BHU5 A0A9Q1BHU5_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_31538 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.5 1.0137 -2.6427 GWYSNDCGH 22.3091 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BHV5 A0A9Q1BHV5_HOLLE "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)" HOLleu_32997 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487] Golgi membrane [GO:0000139]; Golgi stack [GO:0005795] "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0008455]; metal ion binding [GO:0046872]" 1 1.9 0 3.0395 PLKIKPPKP 0 0 0 0 0 0 0 0 0 21.813 22.2078 22.2078 0 0 0 0 0 0 A0A9Q1BHY1 A0A9Q1BHY1_HOLLE Transmembrane protein 39A HOLleu_31788 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.6 1.005 -23.777 LIRRLVWC 0 0 0 0 0 0 20.4195 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BI28 A0A9Q1BI28_HOLLE C2H2-type domain-containing protein HOLleu_33476 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 1 1.3 0.9781 -0.068637 NEDGDEDG 20.5368 21.3342 21.3342 0 0 0 0 0 0 23.1839 22.4977 22.4977 0 0 0 0 0 0 A0A9Q1BI38 A0A9Q1BI38_HOLLE Nuclear receptor subfamily 2 group E member 1 HOLleu_32209 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] 1 3 1.0134 -6.0118 HYGVYACDGCSG 0 0 0 0 0 0 0 0 0 25.3128 0 0 0 0 0 0 0 0 A0A9Q1BI49 A0A9Q1BI49_HOLLE ADP-ribosylation factor-like protein 3 HOLleu_34141 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] 1 3.7 0.97101 -0.068637 PEKRVLVL 0 0 0 19.1557 18.6925 18.6925 0 19.5986 19.5986 0 22.9134 22.9134 21.2827 20.8533 20.8533 0 0 0 A0A9Q1BI50 A0A9Q1BI50_HOLLE Protein D1 HOLleu_32291 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of MAPK cascade [GO:0043409] 1 4.1 1.0268 -23.631 FYRAYYDTYTT 19.9528 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BI82 A0A9Q1BI82_HOLLE Lateral signaling target protein 2-like HOLleu_33906 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) early endosome membrane [GO:0031901] metal ion binding [GO:0046872] 1 2.5 1.0088 -2.7235 TGSSIGSCGSSCSCSSYSDDE 0 0 0 0 19.1635 0 0 22.6614 22.6614 0 0 0 21.1073 20.5968 20.5968 0 22.1058 22.1058 A0A9Q1BI93 A0A9Q1BI93_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_31539 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 3 4.7 1.0041 -24.553 TDCWHDGWYN;TIIIIVIVIVIVTVTV;WGSNCCSHWED 0 17.4139 17.4139 22.2872 20.9036 0 0 0 0 0 0 0 23.6995 22.2477 22.2477 0 0 0 A0A9Q1BI94 A0A9Q1BI94_HOLLE Histone-lysine N-methyltransferase NSD2 HOLleu_34030 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872] 1 0.7 1.0059 -6.2493 KWACPWHHCDECG 0 0 0 0 0 0 0 0 0 21.5326 0 0 0 0 0 0 0 0 A0A9Q1BI97 A0A9Q1BI97_HOLLE Four and a half LIM domains protein 2 HOLleu_31579 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion binding [GO:0008270] 1 1.4 1.0035 -23.777 CFSCSGCG 0 20.7466 20.7466 0 0 0 0 0 0 20.9813 17.1929 17.1929 0 0 0 0 0 0 A0A9Q1BI98 A0A9Q1BI98_HOLLE Baculoviral IAP repeat-containing protein 7-B HOLleu_31598 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630] 1 3.5 1.0178 -23.723 VHDMMFKHC 0 0 0 16.6093 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BIA0 A0A9Q1BIA0_HOLLE Synaptotagmin-like protein 5 HOLleu_31614 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular protein transport [GO:0006886] small GTPase binding [GO:0031267] 3 2.1 0.9971 -30.311 EESPDSLKGPD;EHEDSQEDHWEEQE;HEDSQEDHWEEQEE 0 23.6431 23.6431 0 18.0996 0 17.5589 17.2938 17.2938 21.1972 0 0 19.8841 19.838 19.838 0 0 0 A0A9Q1BIB1 A0A9Q1BIB1_HOLLE MACPF domain-containing protein HOLleu_34194 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 3.5 1.0198 -5.6182 GNPEGGDA;TYYHTTQKFCM 21.2737 0 0 0 0 0 0 24.2139 24.2139 0 0 0 0 0 0 0 0 0 A0A9Q1BIC7 A0A9Q1BIC7_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_31323 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; phosphorylation [GO:0016310]; regulation of signal transduction [GO:0009966] cytosol [GO:0005829] ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein serine/threonine kinase activity [GO:0004674] 1 0.4 1.0034 -4.979 KLPLRRLYVF 0 0 0 18.9838 19.9465 19.9465 0 20.7603 20.7603 0 0 0 0 0 0 17.7803 0 19.5061 A0A9Q1BID6 A0A9Q1BID6_HOLLE Organic cation transporter-like protein HOLleu_31941 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 1 3 1.0271 -23.723 EMEDEVYSY 0 20.8863 20.8863 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BIE4 A0A9Q1BIE4_HOLLE Zinc finger PHD-type domain-containing protein HOLleu_32031 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 2 1 1.0127 -12.261 NHFLDDAECNHQ;NTNHFLDDAECNH 20.4691 0 0 16.1527 16.5803 16.5803 21.7998 0 0 22.3825 20.6452 20.6452 18.5401 18.8023 18.8023 0 0 0 A0A9Q1BIF8 A0A9Q1BIF8_HOLLE ATP-dependent RNA helicase (EC 3.6.4.13) HOLleu_31652 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" nucleolus [GO:0005730] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] 2 4.5 1.0084 -6.3257 DDESDSSGDDEEE;VEENSESDSESEEDDGSDDDD 22.2915 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BII1 A0A9Q1BII1_HOLLE Tubulin alpha chain HOLleu_31917 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] 1 2.4 1.0252 -5.5496 AGGEDVEDEEY 0 22.4284 22.4284 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BII5 A0A9Q1BII5_HOLLE Natterin-3 HOLleu_32006 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2 0.3913 -0.068637 TPRVLPVL 0 0 0 19.3879 0 20.2772 0 22.011 22.011 0 0 0 0 0 0 18.4645 0 19.2387 A0A9Q1BIM8 A0A9Q1BIM8_HOLLE Protein dopey-1 HOLleu_32403 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi to endosome transport [GO:0006895] cytosol [GO:0005829]; endosome [GO:0005768]; trans-Golgi network [GO:0005802] 2 0.7 0.99708 -29.326 DFAIFCSEVDQ;TSSSSGSN 0 0 0 0 0 0 21.5062 21.2109 21.2109 0 19.6642 19.6642 17.3345 0 0 0 0 0 A0A9Q1BIN6 A0A9Q1BIN6_HOLLE C2H2-type domain-containing protein HOLleu_32412 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2 1.0276 -5.5496 CNQMDTPWSDY 0 0 0 0 0 0 0 0 0 23.264 0 0 0 0 0 0 0 0 A0A9Q1BIT4 A0A9Q1BIT4_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_32513 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1 1.0151 -5.7538 QPTTTTVVTTQPTTT 0 24.8816 24.8816 0 0 0 0 0 20.1282 21.4778 21.1972 21.1972 19.6427 19.774 19.774 0 0 0 A0A9Q1BIU9 A0A9Q1BIU9_HOLLE IgGFc-binding protein HOLleu_32551 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201] 4 1.2 1.0046 -8.7583 CMSGCEDEC;CYCNHGYGGN;EEVCSTHPCMDSPCVNGGECMAS;GESGCYCNHGYGGNGLIC 21.6244 0 0 22.4705 0 22.7357 0 0 0 0 24.8794 24.8794 0 0 0 0 0 0 A0A9Q1BIW8 A0A9Q1BIW8_HOLLE Uncharacterized protein HOLleu_32525 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 18 0.97175 -0.10677 IPKIKYELKII 0 0 0 21.7007 22.5299 22.5299 23.9062 0 0 26.4069 0 0 0 0 0 20.9202 21.5648 21.5648 A0A9Q1BIY5 A0A9Q1BIY5_HOLLE Metalloendopeptidase (EC 3.4.24.-) HOLleu_32546 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] 1 2.1 1.0253 -5.5496 MAMRHWERNTC 21.05 18.7399 18.7399 0 0 0 0 0 0 0 16.8604 16.8604 0 0 0 0 0 0 A0A9Q1BJ13 A0A9Q1BJ13_HOLLE Uncharacterized protein HOLleu_32673 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.4 1.0137 -2.6427 SEVEDMSES 0 21.9692 21.9692 0 0 0 0 0 0 21.0634 0 0 0 0 0 0 0 0 A0A9Q1BJ15 A0A9Q1BJ15_HOLLE Histone deacetylase 8 (EC 3.5.1.98) (Protein deacetylase HDAC8) (Protein decrotonylase HDAC8) HOLleu_32683 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of transcription by RNA polymerase II [GO:0000122] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] histone deacetylase activity [GO:0004407] 1 2 0.97857 -0.068637 MLLLGGGG 0 0 0 0 0 0 0 0 0 23.739 0 0 0 0 0 0 0 0 A0A9Q1BJ26 A0A9Q1BJ26_HOLLE "Dynein heavy chain 10, axonemal" HOLleu_32672 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cilium movement involved in cell motility [GO:0060294]; outer dynein arm assembly [GO:0036158] 9+2 motile cilium [GO:0097729]; microtubule [GO:0005874]; outer dynein arm [GO:0036157] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] 3 0.7 1.0076 -9.7955 AMDDSWGCF;IPKGVVLRHI;YVRIVKFY 24.8125 26.4476 26.4476 22.1124 23.1322 22.9165 0 23.9186 24.0102 24.6333 26.1994 26.1994 23.6985 23.7413 23.7413 0 22.1014 22.2535 A0A9Q1BJ47 A0A9Q1BJ47_HOLLE Protein SCAF8 HOLleu_32638 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] RNA binding [GO:0003723] 2 1.1 1.0048 -2.7113 GGIPPQAG;KPLLDIVIP 0 22.8579 22.8579 18.4553 20.2038 20.2038 21.3495 20.1607 20.1607 23.6079 20.7186 20.7186 18.4354 0 0 16.8926 0 18.3762 A0A9Q1BJ55 A0A9Q1BJ55_HOLLE Reticulon-4 receptor HOLleu_32754 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 1 2.4 1.024 -5.5496 TVYTCEQVCWY 22.6771 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BJ70 A0A9Q1BJ70_HOLLE Guanine nucleotide exchange protein SMCR8 HOLleu_32676 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) autophagy [GO:0006914] cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] 1 1.3 1.0234 -23.675 PIKLDYEMCN 0 0 0 0 0 0 19.6585 19.9064 19.9064 0 0 0 0 0 0 0 0 0 A0A9Q1BJ88 A0A9Q1BJ88_HOLLE G-protein coupled receptor moody HOLleu_32825 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] 1 3.6 1.0233 -5.5496 LIIYCYWSLFK 23.3543 0 0 0 0 0 0 0 20.0074 0 0 0 20.2445 19.824 19.824 17.1257 0 0 A0A9Q1BJC4 A0A9Q1BJC4_HOLLE Uncharacterized protein HOLleu_29718 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5 0.97872 -0.068637 QPGEGYAM 0 0 0 0 0 0 0 0 0 0 21.3377 21.3377 0 0 0 0 0 0 A0A9Q1BJE0 A0A9Q1BJE0_HOLLE Reverse transcriptase domain-containing protein HOLleu_29761 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 4.5 1.0099 -11.395 WMHACMHACMHACMYVCMY 0 0 0 0 0 0 0 0 0 0 18.8744 18.8744 0 0 0 0 0 0 A0A9Q1BJE5 A0A9Q1BJE5_HOLLE Fibropellin-1 HOLleu_29748 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.7 0.95908 -0.17167 DPSSCDAVDNCEGSPCSNGGFCLDQ 0 0 0 0 0 0 0 21.4733 21.4733 0 0 0 0 0 0 0 0 0 A0A9Q1BJG1 A0A9Q1BJG1_HOLLE Fibropellin-1 HOLleu_29797 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 0.4 1.0252 -23.675 YNEPAATDNA 0 0 0 0 0 0 0 0 0 0 0 0 17.0486 0 0 0 0 0 A0A9Q1BJI1 A0A9Q1BJI1_HOLLE Delta-like protein C HOLleu_29796 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 2 4 1.0079 -6.3441 GGWSEWSSWG;KRDLQLRRN 0 0 0 0 0 0 0 21.82 21.82 0 0 0 0 0 0 0 0 0 A0A9Q1BJJ1 A0A9Q1BJJ1_HOLLE Calcium-activated chloride channel regulator 4 HOLleu_29824 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] intracellular calcium activated chloride channel activity [GO:0005229] 1 0.6 1.005 -23.777 YFCGNSTT 19.4626 20.0439 20.0439 0 0 0 0 0 0 0 19.1091 19.1091 0 0 0 0 0 0 A0A9Q1BJJ5 A0A9Q1BJJ5_HOLLE Ig-like domain-containing protein HOLleu_32870 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1 1.0246 -5.5496 PRIILKKTRHI 20.9869 22.011 22.011 0 19.151 19.151 20.9969 20.6665 20.6665 22.6593 21.7761 21.7761 0 19.3304 19.3304 0 0 0 A0A9Q1BJK1 A0A9Q1BJK1_HOLLE FH2 domain-containing protein 1 HOLleu_29841 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular component organization [GO:0016043] actin binding [GO:0003779] 1 0.3 0.98592 -0.068637 PAPGMPKS 0 0 0 0 0 0 0 0 0 0 0 0 21.0448 0 0 0 0 0 A0A9Q1BJL7 A0A9Q1BJL7_HOLLE Ubinuclein-2 HOLleu_29922 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] 1 0.8 0.97902 -0.068637 LGMAHLPM 0 0 0 0 0 0 21.9777 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BJN4 A0A9Q1BJN4_HOLLE Acid-sensing ion channel 1C HOLleu_29854 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] ligand-gated sodium channel activity [GO:0015280] 1 3.2 1.0189 -2.6427 QWALDDSHQ 0 0 0 0 0 0 22.3434 22.3405 22.3405 0 0 0 0 0 0 0 0 0 A0A9Q1BJQ2 A0A9Q1BJQ2_HOLLE Carnosine N-methyltransferase 2 HOLleu_29780 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.8 1.0245 -5.5496 AEITSKLLKKE 17.9758 21.1442 21.1442 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BJQ3 A0A9Q1BJQ3_HOLLE Tumor necrosis factor receptor superfamily member 16 HOLleu_29960 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Rho protein signal transduction [GO:0007266] cell surface [GO:0009986]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; death receptor activity [GO:0005035]; nerve growth factor binding [GO:0048406] 1 3.5 1.0145 -6.0779 RLPGRTVYSCKMKF 0 0 0 0 0 0 0 0 0 22.5755 0 0 0 0 0 0 0 0 A0A9Q1BJQ7 A0A9Q1BJQ7_HOLLE Protein Jade-3 HOLleu_29998 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] histone acetyltransferase complex [GO:0000123] metal ion binding [GO:0046872] 2 0.6 1.0008 -2.8407 ESSPHISTCPS;KLPDSHQLQ 0 0 0 20.0032 20.5476 20.5476 0 0 0 0 0 0 0 0 0 0 0 19.487 A0A9Q1BJR4 A0A9Q1BJR4_HOLLE Fibropellin-1 HOLleu_29801 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 2 0.8 1.0101 -5.292 GALACDDS;TCLCADGFNGTYCEENI 0 21.1134 21.1134 0 22.3694 22.3694 0 0 0 19.755 19.2351 19.2351 0 0 0 0 0 0 A0A9Q1BJS4 A0A9Q1BJS4_HOLLE C2 domain-containing protein 3 HOLleu_29935 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) centriole elongation [GO:0061511]; cilium assembly [GO:0060271] centriolar satellite [GO:0034451]; centriole [GO:0005814] 1 0.4 1.0234 -23.675 PLKYLLLKRT 0 0 0 0 23.5637 23.5637 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BJU2 A0A9Q1BJU2_HOLLE Glutamate receptor 4 HOLleu_30029 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; postsynaptic density membrane [GO:0098839] AMPA glutamate receptor activity [GO:0004971]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] 1 0.9 0.38095 -0.068637 RPSIIPVL 21.5803 0 0 0 20.2772 0 22.1281 0 0 23.7515 23.2849 23.2849 0 0 0 0 0 0 A0A9Q1BJW1 A0A9Q1BJW1_HOLLE Protein YIPF HOLleu_30099 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280] Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] 1 3 1.0035 -23.777 DQQGFYQY 0 18.9375 18.9375 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BJW4 A0A9Q1BJW4_HOLLE Epidermal growth factor-like protein 6 HOLleu_29898 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 2.1 0.99631 -4.7869 CDENAHCINAPNGYDCQC 0 0 0 0 0 0 0 22.8431 22.8431 0 0 0 0 0 0 0 0 0 A0A9Q1BJY3 A0A9Q1BJY3_HOLLE Coiled-coil domain-containing protein 73 HOLleu_29934 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 0.40909 -0.068637 SGYGEMGS 0 0 0 0 0 0 0 22.3518 22.3518 0 0 0 0 0 0 0 0 0 A0A9Q1BJY6 A0A9Q1BJY6_HOLLE Matrix metalloproteinase-24 HOLleu_29950 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] 1 3 1.015 -5.7538 SYYHGDSYPFDGPNG 0 21.9654 21.9654 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BK14 A0A9Q1BK14_HOLLE CCHC-type domain-containing protein HOLleu_30014 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 0.94611 -0.068637 KPGGTSGE 23.6601 0 0 19.7196 0 0 18.8561 18.7451 18.7451 0 0 0 19.5704 0 0 0 0 18.755 A0A9Q1BK17 A0A9Q1BK17_HOLLE Uncharacterized protein HOLleu_30185 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.6 1.0136 -2.6427 HYIVLVKNP 21.3578 23.5606 23.5606 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BK31 A0A9Q1BK31_HOLLE Solute carrier family 13 member 3 HOLleu_30198 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] citrate transmembrane transporter activity [GO:0015137]; salt transmembrane transporter activity [GO:1901702]; succinate transmembrane transporter activity [GO:0015141] 1 1.3 1 -0.068637 GSLSAGFM 0 0 0 0 0 0 20.7771 23.7396 23.7396 0 0 0 16.2141 0 0 0 0 0 A0A9Q1BK39 A0A9Q1BK39_HOLLE Fanconi anemia group B protein-like HOLleu_30215 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) interstrand cross-link repair [GO:0036297]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414] Fanconi anaemia nuclear complex [GO:0043240] 1 2 1.0181 -17.224 SVDSHDTSVQDDSMTD 0 0 0 0 0 0 0 0 0 0 16.777 16.777 0 0 0 0 0 0 A0A9Q1BK47 A0A9Q1BK47_HOLLE Pre-mRNA 3'-end-processing factor FIP1 HOLleu_30267 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA processing [GO:0006397] nucleus [GO:0005634] 2 2.5 1.0083 -7.1528 RNCWLQVI;SDDDSEDDDV 0 0 0 0 0 0 0 0 0 0 22.9748 22.9748 0 0 0 0 0 0 A0A9Q1BK67 A0A9Q1BK67_HOLLE Protein Shroom3 HOLleu_30275 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin filament organization [GO:0007015]; cell morphogenesis [GO:0000902] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864] actin filament binding [GO:0051015] 1 0.5 1.0039 -23.777 RPQRRGTL 0 0 0 0 0 0 0 20.0011 20.0011 0 0 0 0 0 0 0 0 0 A0A9Q1BK95 A0A9Q1BK95_HOLLE MBT domain-containing protein 1 HOLleu_30338 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064] 2 1.2 1.0084 -6.318 GWENSFDQWTDCE;IDILKRMG 22.1793 21.938 21.938 0 0 0 18.6543 0 0 0 0 0 19.0066 19.6703 19.6703 0 0 0 A0A9Q1BKA3 A0A9Q1BKA3_HOLLE Eukaryotic translation initiation factor 5B HOLleu_30381 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation initiation factor activity [GO:0003743] 1 2.3 1.0023 -4.125 GEEEEGSSDEEEEDDEEEED 22.4818 0 0 0 0 0 17.5834 0 0 19.9868 19.8489 19.8489 0 17.7426 17.2682 0 0 0 A0A9Q1BKB3 A0A9Q1BKB3_HOLLE MAX gene-associated protein HOLleu_30328 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein dimerization activity [GO:0046983] 2 0.6 1.0031 -3.8242 KSKKKDKASKKRKRSESSSED;MSMEGSHP 21.2914 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BKF1 A0A9Q1BKF1_HOLLE Neuromedin-B receptor HOLleu_30481 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] neuropeptide receptor activity [GO:0008188] 1 2.2 1.0039 -23.777 RLIQYILH 0 0 0 0 0 0 0 0 0 19.912 20.2035 20.2035 19.696 0 0 0 0 0 A0A9Q1BKH3 A0A9Q1BKH3_HOLLE Syntaxin-binding protein 4 HOLleu_30501 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.9 1.0042 -23.777 NMEMDYEE 0 0 0 0 0 0 17.6924 18.2875 18.2875 18.4705 17.1506 17.1506 0 0 0 0 0 0 A0A9Q1BKJ7 A0A9Q1BKJ7_HOLLE Histone PARylation factor 1 HOLleu_30438 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA damage response [GO:0006974] chromosome [GO:0005694]; nucleus [GO:0005634] histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572] 1 2 1.005 -23.777 NLKKMFKK 0 17.9819 17.9819 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BKL8 A0A9Q1BKL8_HOLLE Uncharacterized protein HOLleu_30575 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.7 1.0046 -23.777 PDWCDEYW 0 0 0 0 0 0 0 0 0 20.0994 0 0 0 0 0 0 0 0 A0A9Q1BKM1 A0A9Q1BKM1_HOLLE Short-chain collagen C4 HOLleu_30633 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581]; extracellular space [GO:0005615] 1 2.6 1 -0.068637 MGRDGRDG 0 0 0 0 0 0 0 0 0 20.8823 0 0 0 0 0 0 0 0 A0A9Q1BKM5 A0A9Q1BKM5_HOLLE LamG-like jellyroll fold domain-containing protein HOLleu_30417 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.1 1.0145 -2.6427 QSGNSDCCS 19.4979 21.2272 21.2272 0 0 0 0 0 0 20.1407 19.7582 19.7582 0 0 0 0 0 0 A0A9Q1BKN0 A0A9Q1BKN0_HOLLE Tumor necrosis factor receptor superfamily member 19 HOLleu_30566 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] 1 3.8 1 -0.31124 GEFFNDDCYGTSGPGTCSPCDTGY 0 0 0 0 0 0 26.2232 23.3632 23.3632 0 0 0 0 0 0 0 0 0 A0A9Q1BKP6 A0A9Q1BKP6_HOLLE Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) HOLleu_30437 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 2 1.0193 -23.723 NCNYRHGFH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16.0921 16.0921 A0A9Q1BKT3 A0A9Q1BKT3_HOLLE Alpha-amylase (EC 3.2.1.1) HOLleu_30724 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate metabolic process [GO:0005975] extracellular space [GO:0005615] alpha-amylase activity [GO:0004556]; metal ion binding [GO:0046872] 1 1.1 1.0058 -23.777 QRGHGGGG 0 0 0 0 0 0 0 0 0 0 0 0 17.7966 0 0 0 0 0 A0A9Q1BKU2 A0A9Q1BKU2_HOLLE Sushi repeat-containing protein SRPX HOLleu_30727 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023] 1 7.2 1.0076 -6.2493 TCSYGNRYGSDCN 0 0 0 0 0 0 21.3864 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BKY1 A0A9Q1BKY1_HOLLE Uncharacterized protein HOLleu_30619 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.3 1.0246 -23.723 PKIVIWGHL 0 0 0 0 17.304 17.304 18.6123 0 0 20.3071 0 0 0 0 0 0 0 0 A0A9Q1BKY4 A0A9Q1BKY4_HOLLE Uncharacterized protein HOLleu_30847 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.7 1.0248 -5.5496 IGGHGGKTPLE 0 0 0 0 0 0 0 20.8666 20.8666 0 0 0 0 0 0 0 0 0 A0A9Q1BKZ5 A0A9Q1BKZ5_HOLLE IQ domain-containing protein M HOLleu_30807 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2 1.0127 -2.6427 KLPPKPIKP 0 20.6784 20.6784 17.0232 17.5419 17.5419 19.67 20.2914 19.1639 0 0 0 0 0 0 0 0 0 A0A9Q1BL06 A0A9Q1BL06_HOLLE histone acetyltransferase (EC 2.3.1.48) HOLleu_30828 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of transcription by RNA polymerase II [GO:0045944]; response to stimulus [GO:0050896]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] 1 0.4 1.026 -23.723 KKVVVHAKV 0 0 0 0 0 0 20.7694 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BL15 A0A9Q1BL15_HOLLE E3 ubiquitin-protein ligase TRIM56 HOLleu_30849 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] 1 3 1.0167 -5.8824 SEKKLDLRKIKKLQKQVKQKH 19.2647 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BL33 A0A9Q1BL33_HOLLE Transmembrane protein 131-like conserved domain-containing protein HOLleu_30693 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.5 1.0058 -23.777 YFRPLKKL 0 0 0 0 0 0 0 21.7002 21.7002 0 0 0 0 0 0 0 0 0 A0A9Q1BL76 A0A9Q1BL76_HOLLE Protein SDA1 HOLleu_30964 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein transport [GO:0015031]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055] nucleolus [GO:0005730] 1 2.1 1.0208 -21.924 DEWETASEDSDDSDG 18.9189 19.9074 19.9074 0 0 0 0 0 0 19.5814 19.3947 19.3947 16.0088 0 0 0 0 0 A0A9Q1BL95 A0A9Q1BL95_HOLLE Ferric-chelate reductase 1 HOLleu_31044 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] 1 5.2 1.0151 -6.0779 MCFSHPYDCTEDDR 0 23.2173 23.2173 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BL98 A0A9Q1BL98_HOLLE Nuclear pore complex protein Nup98-Nup96 HOLleu_31089 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA transport [GO:0051028]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; telomere tethering at nuclear periphery [GO:0034398] nuclear membrane [GO:0031965]; nuclear pore cytoplasmic filaments [GO:0044614] arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056] 1 0.4 1.005 -23.777 QAPGPDTS 0 0 0 0 0 0 0 0 0 0 0 0 0 18.3374 18.3374 0 0 0 A0A9Q1BLC5 A0A9Q1BLC5_HOLLE P-type domain-containing protein HOLleu_31082 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.4 1.026 -5.5496 HSDPVVPWCSY 0 0 0 0 0 0 21.4008 21.0666 21.0666 0 0 0 0 0 0 0 0 0 A0A9Q1BLD2 A0A9Q1BLD2_HOLLE Thyrotropin-releasing hormone receptor HOLleu_31112 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] 1 2.6 1.0218 -23.675 YCSMECLFYA 0 0 0 0 0 0 0 0 0 0 18.407 18.407 0 0 0 0 0 0 A0A9Q1BLE3 A0A9Q1BLE3_HOLLE Calcium-activated chloride channel regulator 1 HOLleu_31099 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] intracellular calcium activated chloride channel activity [GO:0005229] 1 0.3 1.006 -6.2493 FCDNNPSDPETFH 19.2821 20.5787 20.5787 0 0 0 22.2034 22.582 22.582 0 0 0 0 0 0 0 0 0 A0A9Q1BLF1 A0A9Q1BLF1_HOLLE beta-N-acetylhexosaminidase (EC 3.2.1.52) HOLleu_28109 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate metabolic process [GO:0005975]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203] lysosome [GO:0005764]; membrane [GO:0016020] beta-N-acetylglucosaminidase activity [GO:0016231] 5 8.7 1.0087 -15.482 EHEYDDGEHEYGDNEHEYGDDEHE;EHEYGDNEHEYGDDEHEYDDGEHE;IQTCEDVPSLESD;VKEYGDGEQEYGEDEHEYGDDE;YGEDEHEYGDDEHE 22.1112 0 0 0 0 0 24.7669 23.0667 23.0667 20.6729 20.2541 20.2541 0 26.8226 26.8226 0 0 0 A0A9Q1BLG2 A0A9Q1BLG2_HOLLE "Translation initiation factor IF-3, mitochondrial" HOLleu_31095 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial translational initiation [GO:0070124]; ribosome disassembly [GO:0032790] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739] ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743] 1 2.5 0.98529 -0.068637 LNVKRKHI 0 0 0 0 0 0 0 0 0 0 22.8972 22.8972 0 0 0 0 0 0 A0A9Q1BLI8 A0A9Q1BLI8_HOLLE Protein dachsous HOLleu_31194 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] 2 0.5 1.0052 -25.897 SDPDGDSH;SEEEFSGSY 0 0 0 0 0 0 0 0 0 0 17.2697 17.2697 0 0 0 0 0 0 A0A9Q1BLI9 A0A9Q1BLI9_HOLLE Calcium-activated chloride channel regulator 1 HOLleu_31156 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; nodal signaling pathway [GO:0038092] cell surface [GO:0009986]; extracellular region [GO:0005576] activin receptor binding [GO:0070697]; nodal binding [GO:0038100] 1 1 1.0215 -23.631 CKQPCHNGGYC 0 0 0 0 0 0 0 0 0 21.0274 20.3555 20.3555 16.9523 17.1775 17.1775 0 0 0 A0A9Q1BLL2 A0A9Q1BLL2_HOLLE Forkhead box protein B1 HOLleu_28117 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 2 4.8 1.0048 -25.897 HGNECRECT;YSYISLTA 23.3886 19.9711 19.9711 0 0 0 0 0 0 18.6325 19.2602 19.2602 0 0 0 0 0 0 A0A9Q1BLM0 A0A9Q1BLM0_HOLLE Structure-specific endonuclease subunit SLX4 HOLleu_28137 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) resolution of meiotic recombination intermediates [GO:0000712] Slx1-Slx4 complex [GO:0033557] DNA binding [GO:0003677]; endonuclease activity [GO:0004519] 2 1 1.013 -11.099 NFDDNDGDGED;QVLKRKRGRPR 0 22.066 22.066 0 0 0 0 0 0 22.2638 21.7321 21.7321 0 0 0 0 0 0 A0A9Q1BLM6 A0A9Q1BLM6_HOLLE Sodium-dependent phosphate transport protein 2B HOLleu_28198 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular phosphate ion homeostasis [GO:0030643]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; vesicle [GO:0031982] sodium:phosphate symporter activity [GO:0005436] 1 3.4 1.0106 -10.943 KPCEGSRVCKYCQCKDEDDE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18.4371 18.4371 A0A9Q1BLQ7 A0A9Q1BLQ7_HOLLE Uncharacterized protein HOLleu_28262 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4 1.0045 -25.65 SNDAEDFDNDDG;SNDAEDFDNDDGSSAYNDYGNFD 21.5503 0 0 0 0 0 0 0 0 0 18.1236 18.1236 0 0 0 0 0 0 A0A9Q1BLR0 A0A9Q1BLR0_HOLLE Transient receptor potential cation channel subfamily M member 3 HOLleu_28272 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein tetramerization [GO:0051262] membrane [GO:0016020] monoatomic cation channel activity [GO:0005261] 1 1.2 1.0099 -11.395 GNVSCLSDSSMRDYSSMPR 0 0 0 0 0 0 0 0 0 0 0 0 0 21.2661 21.2661 0 0 0 A0A9Q1BLT1 A0A9Q1BLT1_HOLLE Protein unc-13-like B HOLleu_28132 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "dense core granule priming [GO:0061789]; neuromuscular junction development [GO:0007528]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]" neuromuscular junction [GO:0031594]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075] 1 0.7 1.0145 -6.0779 HFSCMSSKYMCSGV 0 0 0 0 0 0 23.2054 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BLU8 A0A9Q1BLU8_HOLLE DNA helicase (EC 3.6.4.12) (ATP-dependent helicase ATRX) HOLleu_31188 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281]; negative regulation of macromolecule metabolic process [GO:0010605] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; metal ion binding [GO:0046872] 2 1.1 1 -5.1854 NKSESDEEGDDESTAEED;RKKLKKKQKK 0 0 0 0 0 0 19.3001 0 0 22.2029 0 0 0 0 0 0 0 0 A0A9Q1BLV1 A0A9Q1BLV1_HOLLE Glucosylceramidase (EC 3.2.1.45) HOLleu_28442 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glucosylceramide catabolic process [GO:0006680] glucosylceramidase activity [GO:0004348] 1 3.3 1.0168 -21.924 CSAGYCDTVEDYEPL 20.7233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BLV3 A0A9Q1BLV3_HOLLE Structural maintenance of chromosomes protein 5 HOLleu_28263 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair via homologous recombination [GO:0000724] nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697] 2 2.3 0.98534 -0.78684 ATKSNSKR;QNDCADIKQNREILRKE 19.9058 22.781 22.781 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BLW1 A0A9Q1BLW1_HOLLE Sodium channel protein HOLleu_28460 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228] voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] 1 1.1 1.0064 -2.7235 KLKSLAEKKRKRKEKKKKQKE 0 0 0 0 0 0 16.318 16.5601 16.5601 22.253 21.7611 21.7611 19.1911 18.7738 18.7738 0 0 0 A0A9Q1BLW3 A0A9Q1BLW3_HOLLE Ras GTPase-activating-like protein IQGAP1 HOLleu_28185 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479] mitotic actomyosin contractile ring [GO:0110085] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096] 1 0.5 1.0146 -2.6427 DEYSDFVNP 20.1335 21.961 21.961 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BLX1 A0A9Q1BLX1_HOLLE D-xylulose reductase A HOLleu_28478 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] alcohol dehydrogenase (NAD+) activity [GO:0004022] 1 3.4 1.0109 -6.0118 LQEGEILCKILY 0 25.7615 25.7615 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BLX2 A0A9Q1BLX2_HOLLE Leucine-rich repeat-containing G-protein coupled receptor 4 HOLleu_28407 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615]; membrane [GO:0016020] 1 2.2 1.0049 -6.2493 WYFQYEMIASSTC 25.8342 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BLZ5 A0A9Q1BLZ5_HOLLE "Lon protease homolog, mitochondrial (EC 3.4.21.53)" HOLleu_28241 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrion organization [GO:0007005]; oxidation-dependent protein catabolic process [GO:0070407]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515] mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; single-stranded DNA binding [GO:0003697] 1 0.9 1.0094 -6.0779 SSSSDTVDDNDDEG 0 0 0 0 0 0 0 0 0 0 0 0 22.7946 0 0 0 0 0 A0A9Q1BM06 A0A9Q1BM06_HOLLE Protocadherin Fat 1 HOLleu_28477 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 4.6 1.0045 -23.777 TEPCHNGG 0 0 0 0 0 0 0 0 0 0 0 0 0 19.4902 19.4902 0 0 0 A0A9Q1BM09 A0A9Q1BM09_HOLLE Uncharacterized protein HOLleu_28261 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.7 1.0054 -23.777 KCFKHYDM 20.7537 19.1237 19.1237 0 0 0 0 0 0 0 0 0 0 16.3662 17.0893 0 0 0 A0A9Q1BM11 A0A9Q1BM11_HOLLE Spatacsin HOLleu_28432 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; synaptic vesicle transport [GO:0048489] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; synapse [GO:0045202] 1 0.4 1.0243 -23.675 ATQFHYYCQD 0 0 0 15.1549 0 0 0 15.4007 15.4007 0 15.3369 15.3369 0 0 0 15.1772 0 0 A0A9Q1BM24 A0A9Q1BM24_HOLLE SH2 domain-containing adapter protein B HOLleu_28453 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphotyrosine residue binding [GO:0001784] 1 1.8 1.0234 -23.675 HGEYDNPWEW 0 0 0 15.5464 0 0 0 15.1887 15.1887 0 0 0 0 0 0 14.4329 0 14.7513 A0A9Q1BM27 A0A9Q1BM27_HOLLE RNA-directed DNA polymerase (EC 2.7.7.49) HOLleu_28412 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 0.6 1.0057 -23.777 DNGPGGEC 0 0 0 0 0 0 0 0 0 19.3298 0 0 0 0 0 0 0 0 A0A9Q1BM50 A0A9Q1BM50_HOLLE Uncharacterized protein HOLleu_28622 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.2 1.0058 -23.777 MGTTRQGC 18.8857 17.4274 17.4274 0 0 0 18.2559 17.9811 17.9811 0 0 0 0 0 0 0 0 0 A0A9Q1BM62 A0A9Q1BM62_HOLLE Uncharacterized protein HOLleu_28296 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.7 0.97541 -0.068637 QDGGGCGC 19.8526 21.0499 21.0499 0 0 0 0 0 0 21.3471 20.7872 20.7872 0 0 0 0 0 0 A0A9Q1BM83 A0A9Q1BM83_HOLLE Murinoglobulin-1 HOLleu_28315 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] calcium ion binding [GO:0005509]; serine-type endopeptidase inhibitor activity [GO:0004867] 2 1.3 1.0132 -12.09 GTCWCVDEEGNE;YECINYPGTYECVC 24.8374 0 0 0 0 0 0 0 0 25.4395 21.7052 21.7052 0 0 0 0 0 0 A0A9Q1BM94 A0A9Q1BM94_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_28484 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 4 6.6 0.99646 -75.625 CNNPGWGTHNCGHG;HNCGHGED;WGTICHDLWDD;YHNSQWGTVCDDGWSD 0 23.0283 23.0283 0 18.207 0 0 0 0 21.4463 0 0 21.2206 20.413 20.413 0 0 0 A0A9Q1BMA0 A0A9Q1BMA0_HOLLE Uncharacterized protein HOLleu_28448 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 4 2.3 0.9971 -30.198 KKFFRKQERQT;PWHCEWAHDES;QTPGSNSSS;TKKFFRKQERQTRQKA 0 16.3091 16.3091 0 0 0 0 20.9904 20.9904 0 18.2081 18.2081 0 0 0 0 0 0 A0A9Q1BMB6 A0A9Q1BMB6_HOLLE Leucine-rich repeat-containing protein 15 HOLleu_28677 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of Rho protein signal transduction [GO:0035025] external side of plasma membrane [GO:0009897] ganglioside GM1 binding [GO:1905573]; ganglioside GT1b binding [GO:1905576] 1 5.2 0.96588 -0.17167 FESRIWFYGNYWRCDCKMYDIQQRF 0 0 0 0 0 0 22.0065 0 21.4624 23.0658 23.3749 23.3749 0 21.0419 21.0419 0 0 0 A0A9Q1BME6 A0A9Q1BME6_HOLLE Chromatin assembly factor 1 subunit A HOLleu_28801 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome assembly [GO:0006334] CAF-1 complex [GO:0033186]; nucleus [GO:0005634] 1 1.6 0.99702 -4.7869 DLTDDSEMECDAVDSAQD 0 24.8092 24.8092 0 0 0 0 0 0 22.1889 21.2718 21.2718 0 0 0 0 0 0 A0A9Q1BMI6 A0A9Q1BMI6_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_28649 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; regulation of actin filament length [GO:0030832] cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; protein serine/threonine kinase activity [GO:0004674] 1 0.8 1.0156 -2.6427 EGDECDYDD 26.888 27.7792 27.7792 0 0 0 0 21.6971 21.6971 26.2623 24.0243 24.0243 0 0 0 0 0 0 A0A9Q1BMK8 A0A9Q1BMK8_HOLLE Unconventional myosin-IXa HOLleu_28793 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556] actin filament [GO:0005884]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146] 1 0.6 1.0061 -23.777 HTTGSSHS 0 0 0 0 0 0 21.1726 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BMM7 A0A9Q1BMM7_HOLLE Angiogenic factor with G patch and FHA domains 1 HOLleu_28877 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of angiogenesis [GO:0045766]; vasculogenesis [GO:0001570] nucleic acid binding [GO:0003676] 2 2.2 1.0104 -11.515 SSLSEEDDEMED;SSLSSLSEEDDEMEDE 0 0 0 0 0 0 21.4916 0 0 0 22.791 22.791 0 0 0 0 0 0 A0A9Q1BMQ2 A0A9Q1BMQ2_HOLLE Galactose-1-phosphate uridylyltransferase (EC 2.7.7.12) HOLleu_28640 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) galactose catabolic process via UDP-galactose [GO:0033499] cytoplasm [GO:0005737] UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270] 1 2.3 0.058824 -0.068637 LPKRHVLR 0 30.1987 30.1987 0 18.7428 18.7428 28.3947 20.0566 20.0566 30.5845 30.2084 30.2084 24.9451 26.0177 26.0177 0 0 0 A0A9Q1BMQ3 A0A9Q1BMQ3_HOLLE Glycine receptor subunit alphaZ1 HOLleu_28870 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202] chloride channel activity [GO:0005254]; excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] 1 1.7 1.0058 -23.777 SEQAAHNG 0 0 0 0 0 0 0 0 0 0 0 0 0 21.2174 21.2174 0 0 0 A0A9Q1BMU1 A0A9Q1BMU1_HOLLE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HOLleu_29003 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of membrane depolarization [GO:0003254]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855] voltage-gated potassium channel activity [GO:0005249] 1 1.6 0.95227 -0.1989 LSRALRILRLF 0 0 0 0 0 0 0 0 0 26.4069 0 0 0 0 0 0 0 0 A0A9Q1BMV0 A0A9Q1BMV0_HOLLE DNA helicase (EC 3.6.4.12) HOLleu_28846 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome organization [GO:0034728]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393] 1 0.7 1.0165 -6.0118 ENEGEEDGDEEE 0 23.394 23.394 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BMZ0 A0A9Q1BMZ0_HOLLE PKD/REJ-like domain-containing protein HOLleu_28882 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 0.7 1.0026 -27.8 DCHGTCNGQAYVDECGECVG;DNDQDDFGNT 0 24.0026 24.0026 0 0 0 0 0 0 23.5436 0 0 0 0 0 0 0 0 A0A9Q1BMZ6 A0A9Q1BMZ6_HOLLE Uncharacterized protein HOLleu_29203 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.8 1.0215 -23.631 YSCAWCTCSAE 0 0 0 0 0 0 0 0 0 18.2437 0 0 0 0 0 0 0 0 A0A9Q1BN01 A0A9Q1BN01_HOLLE tubulin-glutamate carboxypeptidase (EC 3.4.17.24) HOLleu_28904 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] cytoplasm [GO:0005737] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] 1 1.4 1.006 -5.2234 GDDVIDVSDDGDDDVSS 21.5171 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BN22 A0A9Q1BN22_HOLLE Uncharacterized protein HOLleu_28880 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.5 1.0061 -23.777 NHYDFGMC 22.2938 0 0 0 0 0 0 0 15.3374 0 16.4772 16.4772 0 0 0 0 0 0 A0A9Q1BN29 A0A9Q1BN29_HOLLE Uncharacterized protein HOLleu_28863 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.9 1.0114 -11.395 CTNADGGCDPDCCCEQTFM 0 18.8396 18.8396 0 0 0 0 0 0 20.7574 0 0 0 0 0 0 0 0 A0A9Q1BN54 A0A9Q1BN54_HOLLE Basigin HOLleu_29002 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-cell adhesion [GO:0098609] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] 1 3.6 1.0088 -6.0779 DDGTYNCHGHESSA 0 20.6039 20.6039 0 0 0 0 0 0 20.533 0 0 0 0 0 0 0 0 A0A9Q1BN60 A0A9Q1BN60_HOLLE Adenylate kinase isoenzyme 6 homolog (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase) HOLleu_29226 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] cytoplasm [GO:0005737]; nucleus [GO:0005634] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] 1 4.4 1.0065 -23.777 EEWDEEYN 0 0 0 0 0 0 0 0 0 16.8855 0 0 0 0 0 0 0 0 A0A9Q1BN64 A0A9Q1BN64_HOLLE SHC-transforming protein-like 1 HOLleu_29345 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of peptidyl-serine phosphorylation [GO:0033138]; signal transduction [GO:0007165] 2 2.2 0.77778 -0.068637 LIKDHSVK;VGKKLGVH 18.8234 20.5774 20.5774 0 0 0 19.1377 18.8833 18.8833 20.6228 0 0 0 0 0 0 0 0 A0A9Q1BNA6 A0A9Q1BNA6_HOLLE Complement receptor type 2 HOLleu_29291 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.3 0.98387 -0.068637 YSNGECAD 19.7235 21.2438 21.2438 0 0 0 0 0 0 0 20.1678 20.1678 16.8842 0 0 0 0 0 A0A9Q1BNC2 A0A9Q1BNC2_HOLLE Uncharacterized protein HOLleu_29074 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 19.2 0.96561 -0.17167 DVLRILKKAKIPKSSISHKEKVLLS 0 19.9549 19.9549 0 0 0 0 0 0 23.4548 0 0 0 0 0 0 0 0 A0A9Q1BNC6 A0A9Q1BNC6_HOLLE Small conductance calcium-activated potassium channel protein HOLleu_29362 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; small conductance calcium-activated potassium channel activity [GO:0016286] 1 1.7 1.0047 -5.2234 ADTESLDYFDDNDYTCA 0 0 0 0 0 0 26.3481 24.9497 24.9497 0 0 0 0 0 0 17.0637 0 18.0529 A0A9Q1BND2 A0A9Q1BND2_HOLLE Uncharacterized protein HOLleu_29090 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 1.0223 -5.5496 YRSLKKLAIKR 0 25.7027 25.7027 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BNF7 A0A9Q1BNF7_HOLLE Pro-interleukin-16 HOLleu_29547 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.4 1.0228 -23.631 GGRSSPRGDVP 0 0 0 15.5191 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BNH8 A0A9Q1BNH8_HOLLE Proprotein convertase subtilisin/kexin type 5 HOLleu_29145 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) peptide hormone processing [GO:0016486] membrane [GO:0016020]; trans-Golgi network [GO:0005802] serine-type endopeptidase activity [GO:0004252] 10 6.8 0.99576 -75.898 CHQSCKSCVDGSEEDCLDCAE;ECHPCHVSCNTCFNSSAD;ECSSESSCTQCIPDYYLNQENGH;FNDCRTCSHNCRD;GCPNHCSKCDEW;GCPNHCSKCDEWGDCT;GGSEPCKTCDEG;GSRDGFECHPCHVSCNTCFNSSADS;NCLSCDYYY;SCSCDGYA 23.3498 27.1476 27.1476 0 17.227 0 25.5365 25.1242 25.1242 25.7238 22.503 22.503 19.6444 19.7712 19.7712 0 0 14.9363 A0A9Q1BNJ9 A0A9Q1BNJ9_HOLLE A disintegrin and metalloproteinase with thrombospondin motifs 12 HOLleu_29223 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 0.7 0.976 -0.068637 WGNWGEWS 0 0 0 0 0 0 0 0 0 0 0 0 20.8764 0 0 0 0 0 A0A9Q1BNK8 A0A9Q1BNK8_HOLLE G-protein coupled receptor 54 HOLleu_29204 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] neuropeptide Y receptor activity [GO:0004983] 1 2.8 1.0007 -4.979 RSIRQKKKTT 0 0 0 0 0 0 22.126 22.7515 22.7515 0 0 0 0 19.7541 19.7541 0 0 0 A0A9Q1BNR0 A0A9Q1BNR0_HOLLE Mucin-like protein HOLleu_29302 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] membrane [GO:0016020] calcium ion binding [GO:0005509] 8 3 0.9961 -65.377 CDEDSVCSPHANCN;CEDINECDEDSVC;CPNHLAGDGFQCYDADEC;DGFQCYDADECAV;DINECSNSSLNECSQNCNNTH;ECSNSSLNECSQNCNN;ECVNNKSSYYCQCGEGY;NGSYTCQCNDGF 23.0492 23.1297 23.1297 0 0 0 22.1166 0 0 23.4664 19.21 19.21 0 22.1448 22.1448 0 0 0 A0A9Q1BNR7 A0A9Q1BNR7_HOLLE C2H2-type domain-containing protein HOLleu_29486 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.8 1.0162 -5.7538 IAGDEEYVENNENWD 23.6595 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BNT4 A0A9Q1BNT4_HOLLE Uncharacterized protein HOLleu_29487 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.7 0.87234 -0.068637 KNHPDGGA 0 0 0 0 0 0 0 0 0 0 0 0 21.6954 0 0 0 0 0 A0A9Q1BNV6 A0A9Q1BNV6_HOLLE RNA polymerase-associated protein CTR9-like HOLleu_29664 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA-templated transcription [GO:0006355]; RNA processing [GO:0006396]; transcription elongation by RNA polymerase II [GO:0006368] Cdc73/Paf1 complex [GO:0016593] RNA polymerase II complex binding [GO:0000993] 1 0.8 1.0248 -23.675 LARLYEARYL 19.4197 21.5957 21.5957 0 0 0 20.1132 0 0 0 20.695 20.695 0 0 0 0 0 0 A0A9Q1BNW7 A0A9Q1BNW7_HOLLE Fibropellin-1 HOLleu_29505 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion [GO:0007155] membrane [GO:0016020] calcium ion binding [GO:0005509] 3 3.5 1.0122 -13.252 ESLFFCDCMSG;MDFDECNSNP;SNCENNTDECASDPCQNNGTC 22.8184 0 0 0 0 0 22.6344 20.0039 20.0039 21.735 24.9813 24.9813 0 0 0 0 0 0 A0A9Q1BNW8 A0A9Q1BNW8_HOLLE Fibrillin-2 HOLleu_29663 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi to vacuole transport [GO:0006896]; protein targeting to vacuole [GO:0006623] endosome [GO:0005768]; extracellular matrix [GO:0031012]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] calcium ion binding [GO:0005509] 7 2.4 0.99541 -78.074 CDCYNGFERSEN;ESNMCSHE;GDDCEACP;GGYGGYGG;GTCINTDGSHECDCYNGFERSEN;GYFECECDMGYALEYDYS;INENGGFHC 22.4535 21.9208 21.9208 0 16.5135 0 0 23.118 23.118 21.6005 21.0057 21.0057 19.9937 20.5282 20.5282 0 0 0 A0A9Q1BNY8 A0A9Q1BNY8_HOLLE Uncharacterized protein HOLleu_29504 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.3 0.97619 -0.068637 PVAAPQGG 0 0 0 0 21.6629 21.6629 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BP05 A0A9Q1BP05_HOLLE Regulator of chromosome condensation HOLleu_29628 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell cycle [GO:0007049]; cell division [GO:0051301] cytoplasm [GO:0005737]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085] 1 3 1.0178 -21.924 SDEESSEDEEVEELG 0 19.9375 19.9375 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BP40 A0A9Q1BP40_HOLLE SKI family transcriptional corepressor 2 HOLleu_29605 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]" 1 1.3 1.0061 -23.777 GMNFTTET 0 0 0 0 0 0 0 0 0 0 21.3853 21.3853 0 0 0 0 0 0 A0A9Q1BP51 A0A9Q1BP51_HOLLE Endonuclease HOLleu_26545 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 1.8 1.0121 -2.2078 PLVSLLMTKELTKLPPRILRFRL 0 0 0 0 0 0 0 0 0 0 0 0 21.7905 0 0 0 0 0 A0A9Q1BP78 A0A9Q1BP78_HOLLE Macrophage mannose receptor 1 HOLleu_26378 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] signaling receptor activity [GO:0038023] 3 1.5 0.99708 -29.483 EPDNAGGG;SWEEAREDCRMRSFNEGSLVTL;TACAEGYQF 20.0245 22.6125 22.6125 0 0 0 21.5755 21.0945 21.0945 0 19.9919 19.9919 18.9564 18.1232 18.1232 0 0 0 A0A9Q1BP96 A0A9Q1BP96_HOLLE Angiopoietin-related protein 7 HOLleu_26562 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 5.1 0.97772 -0.13727 FGNCSCQPSCDDPTGLNNCDDDCLE;NMIFGNCSCQPSCDDPTGLNNCDDD 0 0 0 0 0 0 0 23.1503 23.1503 0 0 0 0 0 0 0 0 0 A0A9Q1BPA5 A0A9Q1BPA5_HOLLE Uncharacterized protein HOLleu_26644 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.4 0.97638 -0.068637 CDSQSMDD 0 0 0 0 0 0 0 0 0 23.091 0 0 0 0 0 0 0 0 A0A9Q1BPB7 A0A9Q1BPB7_HOLLE Zinc finger protein 84 HOLleu_26976 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 1 1.5 1.0014 -4.979 YNCQAHEMTH 0 0 0 19.3321 18.5637 18.5637 19.0376 20.9193 20.9193 19.6649 24.5146 24.5146 22.6764 22.911 22.911 0 0 0 A0A9Q1BPC1 A0A9Q1BPC1_HOLLE "Proline-, glutamic acid- and leucine-rich protein 1" HOLleu_26520 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) rRNA processing [GO:0006364] nucleus [GO:0005634] 1 3.4 1.004 -5.2234 EESHDNDDGQEEKEETG 0 24.8564 24.8564 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BPC2 A0A9Q1BPC2_HOLLE Uncharacterized protein HOLleu_26747 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 18 0.99784 -0.31124 NRSKPVKPNLRPQERKAIGSLRRN 0 24.1499 24.1499 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BPE8 A0A9Q1BPE8_HOLLE "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial" HOLleu_26850 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] ATP binding [GO:0005524]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] 2 1 1.0053 -24.074 FERDCSVQRRHQK;QKDHCDLLRFL 0 0 0 0 0 0 20.2644 0 0 21.615 0 0 0 0 0 0 0 0 A0A9Q1BPG5 A0A9Q1BPG5_HOLLE Neurotrypsin HOLleu_26855 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] membrane [GO:0016020] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] 7 2.3 0.99751 -48.813 CKGNIDEVDCDF;DVMTCDGYVFTEDD;FSYYEEDEYM;GEWGTVCDDDWDE;RDEYHCAP;RFPSGMGG;VEVFYEGEWGTVCDDDWDEN 23.5871 26.0863 26.0863 0 0 0 22.5609 0 0 21.9791 0 0 18.3571 18.6971 18.6971 0 0 0 A0A9Q1BPK0 A0A9Q1BPK0_HOLLE NERD domain-containing protein HOLleu_27150 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 0.96875 -0.068637 VKQKPIEK 0 0 0 0 0 0 0 0 0 0 0 0 0 20.9897 20.9897 0 0 0 A0A9Q1BPL7 A0A9Q1BPL7_HOLLE ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase HOLleu_26944 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of B cell proliferation [GO:0030890] plasma membrane [GO:0005886] NAD+ nucleosidase activity [GO:0003953]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740] 1 2.9 1.0179 -2.6427 CPDDGGCGF 20.6539 21.4738 21.4738 0 16.2067 16.2067 18.6272 0 0 20.979 20.3511 20.3511 17.7015 18.5419 18.5419 0 0 0 A0A9Q1BPQ5 A0A9Q1BPQ5_HOLLE 5'-nucleotidase HOLleu_26893 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) AMP catabolic process [GO:0006196] plasma membrane [GO:0005886] 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] 1 4.3 1.0088 -2.7235 FEQFDENGGKCSMEEAESNQC 0 0 0 0 0 0 0 0 0 0 0 23.1275 0 0 0 0 0 0 A0A9Q1BPS7 A0A9Q1BPS7_HOLLE Angiopoietin-related protein 7 HOLleu_26877 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 1.9 1.0146 -6.0118 EPSCEGDGCMCL 0 21.3948 21.3948 0 0 0 0 0 0 0 21.8988 21.8988 18.9263 0 0 0 0 0 A0A9Q1BPT0 A0A9Q1BPT0_HOLLE Cell division cycle protein 20-like HOLleu_27339 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786] anaphase-promoting complex [GO:0005680] anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757] 1 1.9 1 -4.979 ILAFKQQVPK 22.4994 0 0 0 0 0 0 0 0 0 0 0 18.8277 19.2952 19.2952 0 0 0 A0A9Q1BPU7 A0A9Q1BPU7_HOLLE Uncharacterized protein HOLleu_26965 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.6 1.0058 -23.777 GGGGRATC 0 0 0 0 0 0 0 19.4019 19.4019 0 0 0 0 0 0 0 0 0 A0A9Q1BPU9 A0A9Q1BPU9_HOLLE Neurotrypsin HOLleu_26854 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] membrane [GO:0016020] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] 5 1.6 1.0163 -6.0779 CLDEMAFCDFECLT;GEWGTVCDDDWDE;RDEYHCAP;RFPSGMGG;VEVFYEGEWGTVCDDDWDEN 25.3641 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BPV5 A0A9Q1BPV5_HOLLE phospholipase A2 (EC 3.1.1.4) HOLleu_26931 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cardiolipin acyl-chain remodeling [GO:0035965]; positive regulation of ceramide biosynthetic process [GO:2000304] mitochondrion [GO:0005739] calcium-independent phospholipase A2 activity [GO:0047499] 3 4.4 1.013 -11.168 DSEDDDCFD;SEDDDCFDD;SEDDDCFDDTNDRKDDDVDDD 26.8915 26.5856 26.5856 0 0 0 21.5473 0 0 19.9533 22.4145 22.4145 0 0 0 0 0 0 A0A9Q1BPV6 A0A9Q1BPV6_HOLLE Fatty acid synthase (EC 2.3.1.85) HOLleu_26811 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid biosynthetic process [GO:0006633] cytoplasm [GO:0005737] fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491] 1 5.5 1.022 -5.5496 QFCFTFHSAYR 0 26.672 26.672 0 0 0 17.9345 0 0 20.585 19.5701 19.5701 0 17.6467 17.6467 0 0 0 A0A9Q1BQ03 A0A9Q1BQ03_HOLLE Midasin HOLleu_27179 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.8 1.0131 -5.8824 EMEDDEEDVYEEVDNDEDEMD 19.9001 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BQ21 A0A9Q1BQ21_HOLLE Thiamine transporter 2 HOLleu_26962 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] vitamin transmembrane transporter activity [GO:0090482] 1 2.4 1.029 -23.442 EGLALVGSGMVM 0 23.2014 23.2014 0 0 0 0 0 0 0 0 0 19.218 18.7366 18.7366 0 0 0 A0A9Q1BQ44 A0A9Q1BQ44_HOLLE Uncharacterized protein HOLleu_27573 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281] nucleus [GO:0005634] DNA binding [GO:0003677]; exonuclease activity [GO:0004527]; zinc ion binding [GO:0008270] 3 4.4 0.9961 -53.317 FFVYSQESFFY;PSTDWFCKDC;SPDALVDCSCCS 0 0 0 0 0 0 0 0 0 21.2926 24.2451 24.2451 0 0 0 0 0 0 A0A9Q1BQ57 A0A9Q1BQ57_HOLLE Protein SLX4IP HOLleu_27239 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0043 -23.777 NLCSDDDS 0 20.6446 20.6446 0 0 0 0 0 0 0 17.5462 17.5462 0 0 0 0 0 0 A0A9Q1BQ90 A0A9Q1BQ90_HOLLE Prestalk A differentiation protein A HOLleu_27673 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.7 1.008 -6.2493 QCCSSGSGGGESG 0 0 0 23.4432 24.4352 24.4352 19.7079 0 20.3394 24.3069 0 0 23.1434 0 0 17.6123 0 0 A0A9Q1BQ94 A0A9Q1BQ94_HOLLE CCHC-type domain-containing protein HOLleu_27215 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 7.1 1.0112 -5.5027 RLSGIPGLCKSQQPTT 0 0 0 18.269 19.0264 19.0264 20.0109 20.4581 20.4581 0 22.0401 22.0401 0 20.224 20.224 0 0 18.2137 A0A9Q1BQA2 A0A9Q1BQA2_HOLLE Agrin HOLleu_27428 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 4.8 1.0039 -4.125 ESSSEPDTCDDYPCQNGGSC 25.0023 26.4114 26.4114 0 15.6347 15.6347 0 0 0 24.9324 23.5242 23.5242 0 17.652 17.652 0 0 0 A0A9Q1BQB6 A0A9Q1BQB6_HOLLE "Maltase-glucoamylase, intestinal" HOLleu_27400 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]" 1 2 1.0109 -11.395 RFEIPLEYPREERMVGFRD 0 19.7435 19.7435 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BQE6 A0A9Q1BQE6_HOLLE P2X purinoreceptor 7 intracellular domain-containing protein HOLleu_27323 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.3 1.0182 -23.723 ESDDEIELE 0 18.3199 18.3199 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BQF1 A0A9Q1BQF1_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_27276 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 1 0.9 1.0097 -2.6427 TTDYECHSN 0 0 0 0 0 0 21.1277 14.7883 14.6633 17.7607 17.5768 17.5768 0 0 0 0 0 0 A0A9Q1BQF6 A0A9Q1BQF6_HOLLE Nephrocystin-3 HOLleu_27456 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of apoptotic process [GO:0042981]; Wnt signaling pathway [GO:0016055] ADP binding [GO:0043531] 1 0.8 1.0043 -23.777 QHFDSPMH 0 0 0 0 0 0 0 0 0 0 0 0 18.0616 0 0 0 0 0 A0A9Q1BQH7 A0A9Q1BQH7_HOLLE Integrator complex subunit 6-A HOLleu_27857 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] 1 0.9 1 -0.068637 PSQDTSWH 0 0 0 0 0 0 0 0 0 21.8169 0 0 0 0 0 0 0 0 A0A9Q1BQI7 A0A9Q1BQI7_HOLLE NLR family CARD domain-containing protein 4 HOLleu_27491 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1 1.0199 -5.5496 LNKTKIFILLR 0 24.2684 24.2684 21.8065 0 0 23.2395 23.1668 23.1668 22.3327 0 0 0 0 0 0 22.4065 22.4065 A0A9Q1BQI9 A0A9Q1BQI9_HOLLE Glypican-4 HOLleu_27876 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell migration [GO:0016477]; regulation of protein localization to membrane [GO:1905475]; regulation of signal transduction [GO:0009966] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; synapse [GO:0045202] 1 1.5 0.99237 -0.068637 CGACNGHT 20.6186 22.1849 22.1849 0 0 0 0 0 0 22.4526 21.9857 21.9857 19.017 19.6632 19.6632 0 0 0 A0A9Q1BQJ6 A0A9Q1BQJ6_HOLLE DUF676 domain-containing protein HOLleu_27542 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular lipid metabolic process [GO:0044255] 1 1 1.0047 -23.777 KRRIKYTT 0 0 0 0 0 0 0 18.7505 18.7505 0 0 0 0 0 0 0 0 0 A0A9Q1BQL4 A0A9Q1BQL4_HOLLE Glutamate-rich protein 6 HOLleu_27342 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.1 0.99775 -4.564 DSNFSNMSAHMGEDSEEEE 0 0 0 0 0 0 0 0 0 22.5673 0 0 0 0 0 0 0 0 A0A9Q1BQX4 A0A9Q1BQX4_HOLLE NADPH-dependent aldehyde reductase ARI1 HOLleu_27823 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" 1 4 1.0211 -5.5496 EDDWTDTCNPE 18.0138 19.8663 19.8663 0 16.1933 16.1933 0 0 0 25.8435 21.4077 21.4077 16.9545 17.9177 17.9177 0 0 0 A0A9Q1BQY8 A0A9Q1BQY8_HOLLE Uncharacterized protein HOLleu_27529 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.7 1.0014 -4.979 ACNDSTNVAN 21.5585 20.0017 20.0017 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BQZ2 A0A9Q1BQZ2_HOLLE Delta and Notch-like epidermal growth factor-related receptor HOLleu_27864 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 1 2.1 1.0242 -23.631 SSDPCHNASMC 0 0 0 0 0 0 0 0 0 0 0 0 20.5847 0 0 0 0 0 A0A9Q1BR08 A0A9Q1BR08_HOLLE Centrosomal protein of 290kDa coiled-coil region domain-containing protein HOLleu_24670 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) camera-type eye development [GO:0043010]; ciliary basal body-plasma membrane docking [GO:0097711]; ciliary transition zone assembly [GO:1905349]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515] centriolar satellite [GO:0034451]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737] 1 0.3 0.99242 -0.068637 QRMGGAAG 0 24.3109 24.3109 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BR10 A0A9Q1BR10_HOLLE FAM124 domain-containing protein HOLleu_27618 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.3 0.98496 -0.068637 KAMKPKLT 0 0 0 0 0 0 0 22.5873 22.5873 0 0 0 0 0 0 0 0 0 A0A9Q1BR18 A0A9Q1BR18_HOLLE Uncharacterized protein HOLleu_27656 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 14.8 1.0053 -6.2493 ISGDCCSYCEIEG 0 0 0 0 0 0 0 0 0 20.9625 0 0 0 0 0 0 0 0 A0A9Q1BRB0 A0A9Q1BRB0_HOLLE Cohesin subunit SA-2 HOLleu_27906 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sister chromatid cohesion [GO:0007062] chromatin [GO:0000785]; cohesin complex [GO:0008278]; nucleus [GO:0005634] chromatin binding [GO:0003682] 1 1.9 1.021 -5.6907 LEGLYCTPELVSKLELFTNRFK 0 21.4734 21.4734 0 0 0 0 0 0 0 18.5932 18.5932 17.8164 18.4344 18.4344 0 0 0 A0A9Q1BRE3 A0A9Q1BRE3_HOLLE FK506-binding protein 4 HOLleu_24669 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.5 1.0021 -4.979 RIARHRLAGK 0 0 0 0 0 0 0 0 0 0 0 0 0 20.7812 20.7812 0 0 0 A0A9Q1BRE7 A0A9Q1BRE7_HOLLE Remodeling and spacing factor 1 HOLleu_27858 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of DNA-templated transcription [GO:0045892] RSF complex [GO:0031213] histone binding [GO:0042393]; metal ion binding [GO:0046872] 1 1.2 1.0191 -17.224 EESEEIEEDNTSDEDF 20.3872 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BRF2 A0A9Q1BRF2_HOLLE C2H2-type domain-containing protein HOLleu_24973 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4 1.0246 -23.723 TPQFQCNQC 18.9151 19.4872 19.4872 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BRG4 A0A9Q1BRG4_HOLLE Uncharacterized protein HOLleu_28046 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 15.4 1.0125 -6.0118 LVRVKVNLSIRP 0 22.066 22.066 0 0 0 0 0 0 0 17.2809 17.2809 0 0 0 0 0 0 A0A9Q1BRH0 A0A9Q1BRH0_HOLLE C2H2-type domain-containing protein HOLleu_28027 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 1.0268 -23.442 EPEDSQEWDHNE 17.111 0 0 0 0 0 0 19.618 19.1655 0 0 0 0 0 0 0 0 0 A0A9Q1BRI9 A0A9Q1BRI9_HOLLE E3 ubiquitin-protein ligase MSL2 HOLleu_28020 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein ubiquitination [GO:0016567] MSL complex [GO:0072487] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] 1 2.2 1.0146 -2.6427 TNGSDSDSY 0 0 0 0 0 0 21.7428 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BRL1 A0A9Q1BRL1_HOLLE Calcium-activated chloride channel regulator 4A HOLleu_25097 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] intracellular calcium activated chloride channel activity [GO:0005229] 1 0.8 1.0047 -23.777 LGGSSCND 0 0 0 0 0 0 17.8566 17.9101 17.9101 0 0 0 0 0 0 0 0 0 A0A9Q1BRP6 A0A9Q1BRP6_HOLLE Nociceptin receptor HOLleu_28061 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 6.1 0.99573 -0.31124 VGIVGITGNSLVLIVLLRIIKRHK 0 0 0 0 17.3106 0 17.8037 17.793 17.793 25.4729 25.1504 25.1504 19.4683 19.2768 19.2768 0 0 0 A0A9Q1BRR6 A0A9Q1BRR6_HOLLE Uncharacterized protein HOLleu_24699 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.8 1.0241 -23.723 TPAGEEDCF 0 0 0 0 0 0 19.9436 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BRS9 A0A9Q1BRS9_HOLLE Uncharacterized protein HOLleu_24863 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.7 0.7561 -0.068637 VHLWLKKI 0 0 0 0 0 0 0 0 0 0 0 0 21.3836 0 0 0 0 0 A0A9Q1BRT3 A0A9Q1BRT3_HOLLE Ig-like domain-containing protein HOLleu_24877 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.7 1.0047 -23.777 GMYYCECE 21.0969 0 0 0 0 0 0 0 0 0 0 0 0 16.4799 16.4799 0 0 0 A0A9Q1BRU4 A0A9Q1BRU4_HOLLE IgGFc-binding protein HOLleu_24897 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; RNA binding [GO:0003723] 7 2.8 0.99857 -42.712 DTNAFCGEDEGEH;DYYEKLCGMCGTCNSDESDDFL;EEWFNEDCTRRCTCTEN;EFCEEINGPNCFGQSC;FNEDCTRRCTCTENGMQCQD;GMCGTCTDDPADD;VESCNHGDLPSF 26.9515 28.7644 28.7644 0 19.5742 0 23.4275 22.4485 22.4485 26.7479 26.8339 26.8339 22.8231 20.874 20.874 0 0 0 A0A9Q1BRU8 A0A9Q1BRU8_HOLLE Uncharacterized protein HOLleu_24969 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.4 1.0126 -6.0118 EGYIACYDDDFD 21.7798 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BRZ5 A0A9Q1BRZ5_HOLLE G-protein coupled receptor Mth2 HOLleu_24734 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] 1 2.4 1.0047 -6.2493 CQHANSSCSSCLE 0 0 0 0 0 0 0 0 0 22.4318 22.0022 22.0022 0 0 0 0 0 0 A0A9Q1BS06 A0A9Q1BS06_HOLLE Interferon-induced very large GTPase 1 HOLleu_24755 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525] 1 0.6 1.0175 -5.5496 GMLDVYSCFSD 0 22.1049 22.1049 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BS17 A0A9Q1BS17_HOLLE IgGFc-binding protein HOLleu_24899 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509] 3 1.4 0.99893 -46.345 DCSHDNGDFPC;DDNCEVPLLGTCQC;QQYYETCVYD 0 0 0 0 0 0 19.97 19.5834 19.5834 18.8165 18.8357 18.8357 0 0 0 0 0 0 A0A9Q1BS28 A0A9Q1BS28_HOLLE IgGFc-binding protein HOLleu_24900 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509] 3 0.9 1.0033 -26.484 CGTCTDDPNDDF;DLDGDKECLH;GGSPGHWWE 0 19.5989 19.5989 0 0 0 22.542 23.3184 23.3184 20.0359 19.3435 19.3435 0 0 0 0 0 0 A0A9Q1BS43 A0A9Q1BS43_HOLLE Slit-like 2 protein HOLleu_25068 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.6 1.0137 -2.6427 LVAAMKVPV 0 0 0 0 0 0 0 0 0 25.2958 0 0 0 0 0 0 0 0 A0A9Q1BS65 A0A9Q1BS65_HOLLE Death domain-containing protein HOLleu_25071 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 2.7 0.8913 -0.068637 SNAATPDH 20.8146 0 0 0 0 0 0 0 0 0 17.6724 17.6724 0 0 0 0 0 0 A0A9Q1BS77 A0A9Q1BS77_HOLLE IgGFc-binding protein HOLleu_24896 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 5 1.9 1.0092 -14.396 CEQADCECFIWGDDHFC;CEQPNGVPNCEDTCTETCLC;QQYYETCVYD;RGRGRSAA;VESCNHGDLPSF 0 21.507 21.507 21.3817 21.5732 21.5732 21.3735 22.5508 22.5508 22.9271 0 0 0 0 0 21.1138 21.173 21.173 A0A9Q1BS81 A0A9Q1BS81_HOLLE Zinc finger protein 91 HOLleu_25173 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" 2 1.7 1.013 -11.052 CEHCDFGCTDS;DECPEMDTTEVFQCEH 0 21.7215 21.7215 0 0 0 0 22.5234 22.5234 0 0 0 22.2528 16.3167 16.3167 0 0 0 A0A9Q1BSB8 A0A9Q1BSB8_HOLLE Uncharacterized protein HOLleu_25233 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 11.6 1.0027 -23.777 TTDMNNYA 0 0 0 0 0 0 0 15.1445 15.1445 18.0742 0 0 0 0 0 0 0 0 A0A9Q1BSB9 A0A9Q1BSB9_HOLLE IgGFc-binding protein HOLleu_25085 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509] 2 0.7 1.0048 -26.31 MSGGHGGM;YDPCGSACQQTCDGMQSEVCNF 0 26.1583 26.1583 0 0 0 0 0 0 0 20.352 20.352 0 0 0 0 0 0 A0A9Q1BSC4 A0A9Q1BSC4_HOLLE CCHC-type domain-containing protein HOLleu_25373 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) activation of innate immune response [GO:0002218] catalytic activity [GO:0003824]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] 1 2 1.0034 -5.2234 DVETDSMSDEGEPASEP 0 0 0 0 0 0 0 0 0 24.1061 0 0 0 0 0 0 0 0 A0A9Q1BSD3 A0A9Q1BSD3_HOLLE Cubilin HOLleu_25392 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.3 1.0145 -5.7538 QTCHCANGSSCDNKM 20.4434 21.4958 21.4958 0 0 0 0 0 0 20.273 19.7713 19.7713 0 0 0 0 0 0 A0A9Q1BSE0 A0A9Q1BSE0_HOLLE Uncharacterized protein HOLleu_25320 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.3 0.83673 -0.068637 GAKKKGGG 0 0 0 0 0 0 0 0 0 0 21.9263 21.9263 22.1841 0 0 0 0 0 A0A9Q1BSF0 A0A9Q1BSF0_HOLLE Sodium/nucleoside cotransporter 2 HOLleu_25340 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864] plasma membrane [GO:0005886] purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389] 2 4.8 0.99843 -3.3573 NVGKKAIVIIVLFGI;VKWRPVIWG 19.836 21.9614 21.9614 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BSM4 A0A9Q1BSM4_HOLLE Tripartite motif-containing protein 64 HOLleu_25145 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 4.9 1.0094 -6.0779 QNCDFFCKSCMAVV 0 0 0 0 0 0 0 0 0 22.5078 0 0 0 0 0 0 0 0 A0A9Q1BSN3 A0A9Q1BSN3_HOLLE Transglutaminase-like domain-containing protein HOLleu_25296 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] 1 3.1 1.0162 -22.715 RPVISQPKWRHDYD 0 0 0 0 0 0 19.3955 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BSQ4 A0A9Q1BSQ4_HOLLE Bcl-2-like protein 1 HOLleu_25533 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243] mitochondrial outer membrane [GO:0005741] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] 1 4.5 1.027 -23.723 HCATHDMED 0 0 0 0 0 0 18.9785 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BSR6 A0A9Q1BSR6_HOLLE Uncharacterized protein HOLleu_26035 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.8 1.025 -23.723 DRCTEWEQS 0 0 0 0 0 0 21.2438 21.9707 21.9707 0 0 0 0 0 0 0 0 0 A0A9Q1BSR7 A0A9Q1BSR7_HOLLE Midasin HOLleu_25401 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 6.3 1.0125 -11.395 DDDDDDDDDDDDDDDMTHI;DDGDDGDD 0 0 0 0 0 0 0 0 0 19.0331 0 0 0 0 0 0 0 0 A0A9Q1BT09 A0A9Q1BT09_HOLLE Translocator protein HOLleu_25434 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial outer membrane [GO:0005741] 1 5.6 1.0088 -2.6427 GMTCMTTYM 0 23.7793 23.7793 0 0 0 0 0 0 24.5795 24.0512 24.0512 0 0 0 0 0 0 A0A9Q1BT22 A0A9Q1BT22_HOLLE Uncharacterized protein HOLleu_25734 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 4.4 0.80328 -0.068637 GWSYECGQ 23.3221 24.859 24.859 0 20.5911 0 0 0 0 25.6675 25.4075 25.4075 23.9882 23.8137 23.8137 0 0 0 A0A9Q1BT26 A0A9Q1BT26_HOLLE Interferon-induced very large GTPase 1 HOLleu_25866 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525] 1 1 1.0171 -5.7538 YFRCDCSSSQCNHTP 21.2882 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BT42 A0A9Q1BT42_HOLLE Neurotrypsin HOLleu_25779 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.8 1.0081 -6.2493 WGTVCDDDWDDTD 17.2459 23.4556 23.4556 0 0 0 0 14.7085 14.7085 23.4324 0 0 16.7404 0 0 0 0 0 A0A9Q1BT44 A0A9Q1BT44_HOLLE Reverse transcriptase domain-containing protein HOLleu_26285 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.5 0.81034 -0.068637 QGTAMGTS 22.5711 24.4373 24.4373 0 0 0 23.1836 23.2196 23.2196 0 0 0 0 0 0 0 0 0 A0A9Q1BT47 A0A9Q1BT47_HOLLE Collagen alpha-3(VI) chain HOLleu_25842 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] 1 1.3 0.82456 -0.068637 CDGALVCS 0 0 0 0 0 0 0 0 0 23.8533 0 0 0 0 0 0 0 0 A0A9Q1BT53 A0A9Q1BT53_HOLLE E3 ubiquitin-protein ligase TRIM56 HOLleu_25794 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 1 1.8 1.0053 -6.2493 CWEDEIGMYDVRD 0 0 0 0 0 0 0 0 0 0 22.7003 22.7003 0 0 0 0 0 0 A0A9Q1BT95 A0A9Q1BT95_HOLLE Acetylcholine receptor subunit alpha-like 2 HOLleu_25992 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) response to nicotine [GO:0035094] membrane [GO:0016020]; neuron projection [GO:0043005]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] 1 1.8 1.0027 -23.777 DVPFDNSA 0 0 0 0 0 0 0 0 0 17.6195 0 0 0 0 0 0 0 0 A0A9Q1BT97 A0A9Q1BT97_HOLLE Kielin/chordin-like protein HOLleu_25615 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] 5 3.1 1.0117 -13.309 CDHTTCIMH;CEGCFFGG;CETCDSCLYEG;QGMCCLECNG;SHDCDADD 19.4841 26.4305 26.4305 0 16.5369 0 0 21.7009 21.7009 26.084 21.8395 21.8395 0 18.073 18.073 0 0 0 A0A9Q1BTB3 A0A9Q1BTB3_HOLLE Uncharacterized protein HOLleu_25907 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nuclear pore organization [GO:0006999] nuclear pore inner ring [GO:0044611] structural constituent of nuclear pore [GO:0017056] 1 2 1.0218 -5.5496 DDYQNEERYLF 20.9088 17.7899 17.7899 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BTB5 A0A9Q1BTB5_HOLLE sn-1-specific diacylglycerol lipase (EC 3.1.1.116) HOLleu_25911 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) arachidonic acid metabolic process [GO:0019369]; diacylglycerol catabolic process [GO:0046340]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921] cytoplasm [GO:0005737]; dendrite membrane [GO:0032590]; postsynaptic membrane [GO:0045211] lipoprotein lipase activity [GO:0004465] 1 2.1 0.96134 -0.17167 NERQTLITQRQYHQKWQRRLRKLYH 0 0 0 21.4624 19.5256 19.5256 21.5146 21.5226 21.5226 22.6488 22.257 22.257 0 20.5258 20.5258 0 0 18.878 A0A9Q1BTC3 A0A9Q1BTC3_HOLLE Alpha-N-acetylgalactosamine-specific lectin HOLleu_25924 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 4.7 1.026 -23.723 PSQNCVMFS 0 0 0 0 0 0 0 0 0 0 0 0 0 17.5977 17.5977 0 0 0 A0A9Q1BTC6 A0A9Q1BTC6_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_25778 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 3 6.9 0.99783 -34.168 GDSCNEFCTCYN;GLGCADECEEGTFGADC;TPANCEDGWTGSNCNQ 18.1655 27.5427 27.5427 0 17.2034 17.2034 23.0205 0 0 0 23.4135 23.4135 0 19.2722 19.2722 0 0 0 A0A9Q1BTD7 A0A9Q1BTD7_HOLLE Uncharacterized protein HOLleu_25693 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.1 1.0039 -23.777 QPMCGNGG 19.3719 0 0 0 0 0 19.8785 19.8606 19.8606 0 0 0 17.4506 0 0 0 0 0 A0A9Q1BTE9 A0A9Q1BTE9_HOLLE Protein inscuteable-like HOLleu_25713 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) apical protein localization [GO:0045176]; asymmetric cell division [GO:0008356]; establishment of mitotic spindle orientation [GO:0000132]; regulation of asymmetric cell division [GO:0009786] apical cortex [GO:0045179]; membrane [GO:0016020] cytoskeletal anchor activity [GO:0008093] 2 6.5 1.0045 -26.317 LCCGCFFMC;VLIACLAALR 0 23.1004 23.1004 14.3701 15.4815 14.524 16.176 16.1423 16.1423 19.7882 17.5546 17.5546 18.4296 17.078 17.078 14.0578 0 13.9033 A0A9Q1BTF1 A0A9Q1BTF1_HOLLE Fibrinogen-like protein A HOLleu_22919 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 7.5 0.99656 -0.46718 CPAGYYVKED;GNMEYGNCSCEHTCEDPLGCHTDSC 0 0 0 0 0 0 23.0617 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BTG5 A0A9Q1BTG5_HOLLE Uncharacterized protein HOLleu_26122 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.8 0.99964 -47.554 GWAGSGGP;WAGSGGPG 0 21.7038 21.7038 0 0 0 16.4425 0 0 0 17.5592 17.5592 0 16.6641 16.6641 0 0 0 A0A9Q1BTI7 A0A9Q1BTI7_HOLLE Uncharacterized protein HOLleu_26044 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 2.4 1.0072 -8.2517 GDEGDEGEEETGMT;PGGGKVRG 0 0 0 0 0 0 0 0 0 0 0 0 24.2828 0 0 0 0 0 A0A9Q1BTJ4 A0A9Q1BTJ4_HOLLE Neuropeptide FF receptor 2 HOLleu_26063 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 2.4 0.87037 -0.068637 GYSNEQVG 0 0 0 0 0 0 24.364 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BTN8 A0A9Q1BTN8_HOLLE Uncharacterized protein HOLleu_26129 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 3.5 1.0043 -23.777 TSSWGGGG;WGGGGGGGG 16.5581 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BTP6 A0A9Q1BTP6_HOLLE Uncharacterized protein HOLleu_26283 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.5 0.88679 -0.068637 RSSHHIGV 0 0 0 19.7585 19.5386 19.5386 18.6654 19.8913 19.8913 0 21.4006 21.4006 0 0 0 0 0 0 A0A9Q1BTQ5 A0A9Q1BTQ5_HOLLE Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 HOLleu_23117 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) I band [GO:0031674]; membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529]; striated muscle dense body [GO:0055120] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] 1 2 1.0159 -16.819 DETYDQRLTDDTTECTC 0 20.0209 20.0209 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BTR3 A0A9Q1BTR3_HOLLE Acetylcholinesterase HOLleu_25939 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; cholinesterase activity [GO:0004104] 2 1.6 0.99928 -45.742 SSESCGCLLPDGGY;YEMIDNCGQQCSC 0 0 0 0 0 0 0 18.4444 18.4444 23.2884 22.4693 22.4693 0 0 0 0 0 0 A0A9Q1BTR4 A0A9Q1BTR4_HOLLE Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) HOLleu_26022 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] 1 1.6 1.015 -2.2078 RECQSDSGAENEDSDPSNANSDE 0 23.2135 23.2135 0 0 0 0 0 0 0 21.1685 21.1685 0 17.8334 17.8334 0 0 0 A0A9Q1BTR7 A0A9Q1BTR7_HOLLE Solute carrier family 22 member 21 HOLleu_26056 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 2 2.9 1.0057 -23.792 LLTTLALLG;RPTVGIIP 0 0 0 19.0912 20.1003 20.1003 0 20.677 20.677 23.6316 0 0 0 22.3904 22.3904 18.5825 0 19.3517 A0A9Q1BTR9 A0A9Q1BTR9_HOLLE SH3 and multiple ankyrin repeat domains protein 3 HOLleu_26079 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] ionotropic glutamate receptor binding [GO:0035255]; synaptic receptor adaptor activity [GO:0030160] 1 1 1.0268 -23.442 NLDFSQVRKHNN 0 23.7344 23.7344 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BTY4 A0A9Q1BTY4_HOLLE E3 ubiquitin-protein ligase TRIM56 HOLleu_26182 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 1 1.1 1.007 -23.777 PVHIKAIK 0 0 0 0 19.0488 19.0488 20.5114 20.8287 19.8936 0 0 0 20.0231 19.379 19.379 0 0 0 A0A9Q1BTZ6 A0A9Q1BTZ6_HOLLE Transcription intermediary factor 1-beta HOLleu_26205 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 1 2.1 1.0266 -23.631 CDNLPVCMACM 0 19.8943 19.8943 0 0 0 16.7276 16.343 16.343 19.0002 0 0 16.4322 0 0 0 0 0 A0A9Q1BTZ9 A0A9Q1BTZ9_HOLLE Plexin-A4 HOLleu_26108 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] membrane [GO:0016020]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] 1 3.9 1.0072 -2.7235 PDTKDDDHDDNDDDDDDDDDD 23.5755 26.6026 26.6026 0 0 0 18.6 17.5415 17.5415 25.7615 25.0764 25.0764 0 16.8336 16.8336 0 0 0 A0A9Q1BU03 A0A9Q1BU03_HOLLE Uncharacterized protein HOLleu_26106 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 16.9 1.0163 -6.0779 DDDGDDGGGGGNSD 18.5844 20.0672 20.0672 0 0 0 0 0 0 20.92 20.4615 20.4615 15.2367 0 0 0 0 0 A0A9Q1BU31 A0A9Q1BU31_HOLLE Tenascin-R HOLleu_23358 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 2.9 1.013 -16.819 DRREDCECGWWCCPDCN 0 18.5155 18.5155 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BU50 A0A9Q1BU50_HOLLE Transcription intermediary factor 1-beta HOLleu_26202 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 1.2 0.8 -0.068637 LVGGDRSR 0 23.8036 23.8036 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BU53 A0A9Q1BU53_HOLLE Laminin subunit alpha HOLleu_23002 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] basement membrane [GO:0005604]; membrane [GO:0016020] signaling receptor binding [GO:0005102] 3 1.2 0.99746 -31.713 QLCDCDRYGSESCNGTTGECYC;RMCDMCAEGFY;SPDVCQACQCD 23.1236 22.2873 22.2873 0 16.5791 16.5791 17.7848 17.6412 17.6412 23.6619 23.275 23.275 18.2187 0 0 0 0 0 A0A9Q1BU54 A0A9Q1BU54_HOLLE LRAT domain-containing protein HOLleu_26290 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.8 1.0036 -2.5328 CQCGNSNPCLFRAYDDSEDHTM 0 0 0 0 0 0 22.4426 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BU63 A0A9Q1BU63_HOLLE LRAT domain-containing protein HOLleu_22767 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.5 0.82 -0.068637 NLYCICYD 20.6374 21.7281 21.7281 0 0 0 0 0 0 20.8525 19.7577 19.7577 17.07 17.3276 17.3276 0 0 0 A0A9Q1BU93 A0A9Q1BU93_HOLLE Uncharacterized protein HOLleu_22969 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 1.8 0.99783 -33.76 CEDYCNCTFQYGW;GKLDNFCMFECEDDY;TCSGFDMYNC 21.3632 22.9485 22.9485 0 0 0 19.6411 0 0 0 24.0247 24.0247 0 0 0 0 0 0 A0A9Q1BUA0 A0A9Q1BUA0_HOLLE Angiotensin-converting enzyme (EC 3.4.-.-) HOLleu_22815 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of systemic arterial blood pressure [GO:0003084]; proteolysis [GO:0006508]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081] extracellular space [GO:0005615]; plasma membrane [GO:0005886] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241] 1 2.4 1.0074 -6.2493 DCGAYWRSWYETD 0 0 0 0 0 0 0 0 0 22.4176 0 0 0 0 0 0 0 0 A0A9Q1BUD0 A0A9Q1BUD0_HOLLE "Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase)" HOLleu_23135 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid biosynthetic process [GO:0006633] mitochondrion [GO:0005739] trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166] 1 2.2 1.0058 -23.777 NLPKPKLA 0 0 0 15.9659 16.7008 16.7008 18.4962 18.4973 18.4973 19.6466 0 0 0 0 0 0 0 0 A0A9Q1BUD9 A0A9Q1BUD9_HOLLE Fibrinogen-like protein A HOLleu_23048 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.9 1.0154 -21.924 CASTYNSAWWYTNCY 19.2067 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BUE5 A0A9Q1BUE5_HOLLE Zonadhesin HOLleu_22923 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 10.7 1.019 -23.723 CPAGYYVKED;YVDGSCTKK 0 0 0 0 19.8545 0 0 20.5737 20.5737 0 0 0 21.1221 0 0 0 0 0 A0A9Q1BUG2 A0A9Q1BUG2_HOLLE Microcephalin HOLleu_22865 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitotic cell cycle [GO:0000278] 1 0.8 0.84615 -0.068637 KVGAADDG 0 0 0 0 0 0 0 0 0 0 22.5394 22.5394 0 0 0 0 0 0 A0A9Q1BUH6 A0A9Q1BUH6_HOLLE Hemicentin-1 HOLleu_22945 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]" fucose binding [GO:0042806] 3 0.7 1.0107 -12.417 TLCTTTCDTDG;WEYGECSESCYSWDIN;WGAWSECSS 17.6609 18.3493 18.3493 0 0 0 0 21.6048 21.6048 22.398 21.2112 21.2112 15.9144 15.4674 15.4674 0 0 16.3487 A0A9Q1BUH8 A0A9Q1BUH8_HOLLE Ficolin-1 HOLleu_22985 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.4 0.99778 -4.7869 FCPTNMKYDNCSCQATCD 0 22.3847 22.3847 0 0 0 0 0 0 22.5912 21.881 21.881 0 0 0 0 0 0 A0A9Q1BUI2 A0A9Q1BUI2_HOLLE Protein DEK HOLleu_23121 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chromatin organization [GO:0006325]; regulation of double-strand break repair [GO:2000779] nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393] 1 2 1.019 -23.723 TKRKKASAK 0 0 0 0 0 0 20.831 0 0 0 0 0 19.8915 19.8506 19.8506 0 0 0 A0A9Q1BUI3 A0A9Q1BUI3_HOLLE Syntaxin-12 HOLleu_23226 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] 1 2.9 0.85455 -0.068637 GDFGHGGG 0 0 0 0 0 0 0 0 0 0 0 0 22.0368 21.5011 21.5011 0 0 0 A0A9Q1BUJ1 A0A9Q1BUJ1_HOLLE Tenascin-N HOLleu_23142 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.7 1.0045 -23.777 AETNHGGW 0 0 0 0 0 0 0 0 0 0 0 0 20.4299 0 0 0 0 0 A0A9Q1BUJ3 A0A9Q1BUJ3_HOLLE Laminin subunit alpha HOLleu_23245 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; membrane [GO:0016020] signaling receptor binding [GO:0005102] 2 1.3 1 -2.844 CDTRGSQYEGCSENGLCYCQTGFS;DECQEGYYGYPRCDECACSPDG 22.4186 0 0 0 0 0 22.5148 18.2507 18.2507 0 0 0 0 0 0 0 0 0 A0A9Q1BUJ4 A0A9Q1BUJ4_HOLLE Sodium-dependent lysophosphatidylcholine symporter 1 HOLleu_23220 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate transport [GO:0008643] membrane [GO:0016020] symporter activity [GO:0015293] 2 3.6 0.99964 -47.398 PLKQALPKII;VWHVILKKI 0 0 0 0 0 0 20.608 0 0 21.9061 0 0 0 0 0 0 0 0 A0A9Q1BUJ8 A0A9Q1BUJ8_HOLLE Uncharacterized protein HOLleu_23022 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 21.2 1.014 -11.036 IHVCQYVCMSVCM;TCMYVCMYVCMYVCMYVC 20.9134 0 0 0 0 0 0 21.4982 21.4982 0 0 0 0 0 0 0 0 0 A0A9Q1BUL9 A0A9Q1BUL9_HOLLE Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) HOLleu_23059 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) maturation of SSU-rRNA [GO:0030490]; phosphorylation [GO:0016310] "cytosol [GO:0005829]; preribosome, small subunit precursor [GO:0030688]" ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 1 3.7 1.0159 -5.6907 AVKEEKRENRKNKIPKHVKKRK 0 0 0 0 0 0 0 0 0 20.9867 20.7476 20.7476 18.4422 18.3063 18.3063 0 0 0 A0A9Q1BUM4 A0A9Q1BUM4_HOLLE Ficolin-1 HOLleu_23197 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4 1.0143 -5.8824 DCTCQRTCQDPYGCHNTCNED 19.7155 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BUP0 A0A9Q1BUP0_HOLLE Serine O-succinyltransferase HOLleu_23099 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cysteine biosynthetic process from serine [GO:0006535]; homoserine metabolic process [GO:0009092]; methionine biosynthetic process [GO:0009086] mitochondrion [GO:0005739] homoserine O-acetyltransferase activity [GO:0004414]; serine O-acetyltransferase activity [GO:0009001] 1 1.7 1.0054 -23.777 NVGGAIKG 0 0 0 0 19.776 19.776 0 19.2551 19.2551 0 0 0 0 0 0 19.2285 18.2575 18.2575 A0A9Q1BUP1 A0A9Q1BUP1_HOLLE IgGFc-binding protein HOLleu_23313 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 6.7 1.0082 -7.9616 CYINCAGGEACICPD;MNCVCQSTCEYPNSRNSCYINCA 21.1679 0 0 0 0 0 0 25.0675 25.0675 0 18.7718 18.7718 0 0 0 0 0 0 A0A9Q1BUR9 A0A9Q1BUR9_HOLLE Fibrinogen-like protein A HOLleu_23043 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4.7 1.0135 -11.303 CSCQGTCDQPE;GGWWYGYDDGHYYYY 0 22.6273 22.6273 0 0 0 0 0 0 23.4512 0 0 0 0 0 0 0 0 A0A9Q1BUS4 A0A9Q1BUS4_HOLLE Integrase catalytic domain-containing protein HOLleu_23074 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] 2 1.9 1.0046 -23.777 CYEREDCD;YVEFAYQKERHFDRW 0 0 0 0 0 0 0 0 0 0 0 0 17.8476 0 0 0 0 0 A0A9Q1BUT0 A0A9Q1BUT0_HOLLE Peroxisomal assembly protein PEX3 HOLleu_23060 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein import into peroxisome membrane [GO:0045046] peroxisomal membrane [GO:0005778] protein-macromolecule adaptor activity [GO:0030674] 1 3.6 1.0191 -17.224 WKLAEWREIEAAECLA 0 19.2584 19.2584 0 0 0 0 0 0 0 18.8538 18.8538 0 0 0 0 0 0 A0A9Q1BUT2 A0A9Q1BUT2_HOLLE IgGFc-binding protein HOLleu_23312 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 1.0007 -4.979 LHCDCNQGYY 0 0 0 0 0 0 21.1552 22.0238 22.0238 0 0 0 0 0 0 0 0 0 A0A9Q1BUU4 A0A9Q1BUU4_HOLLE Fibrinogen C domain-containing protein 1 HOLleu_23329 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 2.3 0.81356 -0.068637 CQCPDDFF 0 0 0 0 0 0 0 0 0 0 23.3585 23.3585 0 0 0 0 0 0 A0A9Q1BUV2 A0A9Q1BUV2_HOLLE Fibropellin-1 HOLleu_23429 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 2 6.3 1.0063 -6.3892 EGYTGDTCEMEVDPCSSNPCQNGG;MTGKRKDKIKRNRL 0 0 0 0 18.7885 18.7885 24.2076 0 0 21.1458 0 0 0 17.3773 17.3773 17.2669 0 16.4238 A0A9Q1BUW3 A0A9Q1BUW3_HOLLE Kremen protein 1 HOLleu_23230 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 1 2.6 1.0007 -4.979 DEFCDDPCPG 0 22.5761 22.5761 0 0 0 0 0 0 22.5655 0 0 0 0 0 0 0 0 A0A9Q1BUX0 A0A9Q1BUX0_HOLLE Uncharacterized protein HOLleu_23474 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5 1.0256 -23.631 EMIYNSAYESP 0 21.3499 21.3499 0 0 0 20.4057 0 0 0 20.7932 20.7932 0 0 0 0 0 0 A0A9Q1BUX3 A0A9Q1BUX3_HOLLE Myc protein HOLleu_23385 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 2 9.1 0.99744 -29.1 ALQKRDLEKRHRDLV;KRREDLRSAFFRLRDRIPELESKER 0 0 0 0 0 0 0 0 0 0 20.9373 20.9373 0 0 0 0 0 0 A0A9Q1BV07 A0A9Q1BV07_HOLLE NLR family CARD domain-containing protein 4 HOLleu_23229 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676] 1 0.9 1.0014 -4.979 AECFMDCTLM 0 0 0 0 0 0 20.964 20.9364 20.9364 0 0 0 0 0 0 0 0 0 A0A9Q1BV25 A0A9Q1BV25_HOLLE Uncharacterized protein HOLleu_23466 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 4 1.014 -11.303 WGCFCFQDSSD;WGCFCFQDSSDCFMC 24.8886 22.4829 22.4829 0 0 0 0 0 0 20.9106 20.3504 20.3504 0 0 0 0 0 0 A0A9Q1BV38 A0A9Q1BV38_HOLLE Microtubule-actin cross-linking factor 1 HOLleu_23618 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasmic microtubule organization [GO:0031122]; intermediate filament cytoskeleton organization [GO:0045104]; wound healing [GO:0042060] cytoplasm [GO:0005737]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; membrane [GO:0016020] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198] 2 0.7 1.0046 -8.6545 VDVLEETLPLAM;VVRAGRNLR 22.7449 0 0 21.8618 22.6196 22.6196 0 21.8525 21.8525 0 21.3366 21.3366 19.5564 19.8589 19.8589 21.4613 0 21.4038 A0A9Q1BV49 A0A9Q1BV49_HOLLE Titin HOLleu_23403 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615]; membrane [GO:0016020] 1 0.7 1.0184 -5.7538 YRWTEWCDADDGGTS 21.3294 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BV51 A0A9Q1BV51_HOLLE Transcription elongation factor HOLleu_23406 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of mRNA 3'-end processing [GO:0031440]; transcription antitermination [GO:0031564]; transcription elongation by RNA polymerase I [GO:0006362]; transcription elongation by RNA polymerase II [GO:0006368] nucleus [GO:0005634] RNA polymerase II complex recruiting activity [GO:0001139]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; translation elongation factor activity [GO:0003746]; zinc ion binding [GO:0008270] 1 2.7 0.8254 -0.068637 AEIEDCIY 0 0 0 21.4506 21.0553 21.6124 0 0 0 0 0 0 22.9774 0 0 20.8465 0 0 A0A9Q1BV58 A0A9Q1BV58_HOLLE Uncharacterized protein HOLleu_23323 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 11.5 1.0193 -2.6427 HIASLVVFR 0 23.5867 23.5867 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BV81 A0A9Q1BV81_HOLLE Sushi domain-containing protein HOLleu_23441 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5.1 1.0064 -2.7235 PELDCDGEIDPDDDMETEYEG 0 22.3701 22.3701 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BV90 A0A9Q1BV90_HOLLE Angiopoietin-related protein 7 HOLleu_23379 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.9 1.0248 -23.675 CPPNMTHESC 19.8922 20.7265 20.7265 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVA1 A0A9Q1BVA1_HOLLE Fibrinogen-like protein A HOLleu_24338 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.5 1.0259 -23.442 WSTCGTSCGHNS 0 17.8465 17.8465 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVA3 A0A9Q1BVA3_HOLLE Fibrinogen-like protein A HOLleu_23755 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 4.7 0.98611 -0.20876 YSGNADECMPPCPGNMSPGDCSCQ 0 20.6578 20.6578 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVC8 A0A9Q1BVC8_HOLLE Fibrinogen-like protein A HOLleu_24398 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 2.5 1.0143 -6.0118 TCDDAYHCDPNA 18.7693 19.1404 19.1404 0 0 0 0 0 0 19.658 19.5087 19.5087 23.4077 23.6016 23.6016 0 0 0 A0A9Q1BVE7 A0A9Q1BVE7_HOLLE Uncharacterized protein HOLleu_23855 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.3 1.0152 -2.6427 KQRKRYKKK 27.0885 0 0 0 0 0 27.6596 24.3767 0 27.3223 28.5526 28.5526 25.1474 25.5457 25.5457 0 0 0 A0A9Q1BVF2 A0A9Q1BVF2_HOLLE CCHC-type domain-containing protein HOLleu_23721 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 3.2 0.99928 -47.219 KLTRLLQCCKGE;VQLIKKKY 23.5567 0 0 0 19.5896 19.5896 18.4512 18.5857 18.5857 20.9471 0 0 0 0 0 0 0 0 A0A9Q1BVI2 A0A9Q1BVI2_HOLLE Tenascin-R HOLleu_23664 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 2.5 1.0268 -23.631 NEPFEAYCDNE 17.8677 19.6468 19.6468 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVJ6 A0A9Q1BVJ6_HOLLE Uncharacterized protein HOLleu_23829 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0043 -23.777 GGLCACYH 20.0645 0 0 0 0 0 0 0 0 20.2771 20.0938 20.0938 18.8346 19.102 19.102 0 0 0 A0A9Q1BVK8 A0A9Q1BVK8_HOLLE Ryncolin-2 HOLleu_23599 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 6 1.0135 -11.235 CSCISGQFSCNAYQCSS;YYWCGSYCNYNG 23.4825 0 0 0 0 0 0 0 0 26.2447 24.3978 24.3978 0 0 0 0 0 0 A0A9Q1BVL5 A0A9Q1BVL5_HOLLE Ficolin-2 HOLleu_23722 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4.8 1.0053 -24.026 MPSSPATEHSSA;TLLRKLTTT 0 0 0 0 0 0 0 0 0 0 0 0 17.6073 18.2663 18.2663 0 0 0 A0A9Q1BVM4 A0A9Q1BVM4_HOLLE LINE-1 retrotransposable element ORF1 protein HOLleu_23891 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) retrotransposition [GO:0032197] ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] 1 4.5 1.0148 -6.0118 FQGKRIDNLESK 23.8473 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVN0 A0A9Q1BVN0_HOLLE HBS1-like protein HOLleu_23707 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of translation [GO:0006417]; translation [GO:0006412] cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] 1 0.7 1.0042 -23.777 MGHLLFLL 0 0 0 0 0 0 0 21.1003 21.1003 0 0 0 0 0 0 0 0 0 A0A9Q1BVN1 A0A9Q1BVN1_HOLLE Fibrinogen-like protein A HOLleu_23911 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 4.2 1.0127 -5.7538 CDWWPSGNNSCGICT 22.0924 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVN5 A0A9Q1BVN5_HOLLE Angiopoietin-related protein 7 HOLleu_23885 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 3.6 1.0131 -6.0118 YVSSDCSMLCTC 21.9476 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVP0 A0A9Q1BVP0_HOLLE Ryncolin-4 HOLleu_23932 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 9.2 1.0168 -5.7538 CVGVCMCVCFFSCVC 20.0528 21.337 21.337 0 0 0 0 0 0 20.2357 19.5711 19.5711 0 0 0 0 0 0 A0A9Q1BVR0 A0A9Q1BVR0_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_23968 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; mitotic cytokinesis [GO:0000281]; phosphorylation [GO:0016310]; regulation of cell junction assembly [GO:1901888]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; Rho-dependent protein serine/threonine kinase activity [GO:0072518] 1 1.1 0.8913 -0.068637 IPKIFQLL 0 0 0 0 0 0 0 0 0 0 0 0 20.4789 20.7545 20.7545 0 0 0 A0A9Q1BVR5 A0A9Q1BVR5_HOLLE RNA helicase (EC 3.6.4.13) HOLleu_23795 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular membrane-bounded organelle [GO:0043231] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] 1 1.1 1.0193 -2.6427 MKFLLKKKI 23.687 24.4246 24.4246 0 0 0 22.923 20.821 20.821 27.0465 25.2221 25.2221 22.4991 21.5536 21.5536 0 0 0 A0A9Q1BVS3 A0A9Q1BVS3_HOLLE Ficolin-1 HOLleu_23964 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.7 1.0077 -8.2731 CYCNDGYTGDGQNCEVVATDC;EGLLLFLLIFI 22.2348 23.3697 23.3697 0 0 0 0 0 21.4631 23.1293 23.1331 23.1331 20.5391 20.6299 20.6299 0 0 0 A0A9Q1BVS6 A0A9Q1BVS6_HOLLE LRAT domain-containing protein HOLleu_23822 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.7 1.0184 -2.6427 QRSEFHYSD 0 0 0 0 0 0 21.9535 0 0 18.152 17.8238 17.8238 19.0569 0 0 0 0 0 A0A9Q1BVS7 A0A9Q1BVS7_HOLLE Fibrinogen-like protein A HOLleu_24114 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 9.9 1.0004 -28.51 CTCNGNGLTCNDYNCDTN;TNMIHGNCT 0 20.2287 20.2287 0 0 0 24.5052 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVW2 A0A9Q1BVW2_HOLLE Nipped-B-like protein B HOLleu_21045 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.3 0.8125 -0.068637 RKRKKERKKKKERKRKKERKKERKR 0 0 0 0 0 0 20.8079 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BVZ4 A0A9Q1BVZ4_HOLLE Angiopoietin-related protein 1 HOLleu_23882 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 3.9 1.0184 -5.6907 NPETTNWCPQCYGSYCYYFQYS 0 0 0 0 0 0 20.0754 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BW20 A0A9Q1BW20_HOLLE Fibrinogen C domain-containing protein 1-A HOLleu_24283 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "blood coagulation, common pathway [GO:0072377]; fibrinolysis [GO:0042730]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; protein polymerization [GO:0051258]" fibrinogen complex [GO:0005577]; membrane [GO:0016020] extracellular matrix structural constituent [GO:0005201] 2 2 1.0077 -8.1923 CVQQERCGC;TDGHQCYCNEG 0 0 0 21.4121 0 21.4257 21.9472 0 0 0 0 0 17.9605 18.1172 18.1172 0 0 0 A0A9Q1BW33 A0A9Q1BW33_HOLLE Eukaryotic translation initiation factor 3 subunit H (eIF3h) HOLleu_24330 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) formation of cytoplasmic translation initiation complex [GO:0001732] cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] metallopeptidase activity [GO:0008237]; translation initiation factor activity [GO:0003743] 1 2.4 1.0011 -23.777 DDEQYQME 0 0 0 0 0 0 0 0 0 0 0 0 0 21.1292 21.1292 0 0 0 A0A9Q1BW34 A0A9Q1BW34_HOLLE Uncharacterized protein HOLleu_24198 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.7 1.0212 -5.5496 CNFYMHCDEYM 0 21.416 21.416 18.3714 18.5883 18.5883 19.9498 20.1088 20.1088 0 21.8575 21.8575 0 18.717 18.717 0 0 0 A0A9Q1BW49 A0A9Q1BW49_HOLLE Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 HOLleu_24067 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein modification process [GO:0036211] cytoplasm [GO:0005737] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] 3 4.7 1.0138 -11.63 EEEDDDDD;QQNSESGCDGEE;VEEDDDNDDDS 21.3177 18.2593 0 0 0 0 17.5699 0 0 22.0194 23.8868 23.8868 18.9118 19.0419 19.0419 0 0 0 A0A9Q1BW57 A0A9Q1BW57_HOLLE Bladder cancer-associated protein HOLleu_24213 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 17.1 1.0142 -6.0779 YPNCAFIMCDQTCD 22.4272 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BW61 A0A9Q1BW61_HOLLE Fibrinogen-like protein A HOLleu_24129 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 4.5 1.0164 -16.819 LNGSDCVTPEECQCYSS 0 0 0 0 0 0 0 0 0 20.9214 0 0 17.5666 0 0 0 0 0 A0A9Q1BW62 A0A9Q1BW62_HOLLE Xylose isomerase (EC 5.3.1.5) HOLleu_24024 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) D-xylose metabolic process [GO:0042732] metal ion binding [GO:0046872]; xylose isomerase activity [GO:0009045] 1 2.1 1.017 -2.6427 ERPWDDGSE 20.6926 24.5411 24.5411 0 15.7098 15.7098 0 0 0 21.1664 20.824 20.824 18.9893 19.6096 19.6096 0 0 0 A0A9Q1BW82 A0A9Q1BW82_HOLLE Ryncolin-2 HOLleu_24424 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6 1.0138 -5.5027 YCNEGYVGDGVNCTFD 0 0 0 0 0 0 0 22.7716 22.7716 0 0 0 0 0 0 0 0 0 A0A9Q1BW93 A0A9Q1BW93_HOLLE Zonadhesin HOLleu_24445 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.7 1.0206 -5.5496 CTCEKSCNNPE 20.5403 22.0131 22.0131 16.2267 17.179 17.179 0 0 0 24.9958 24.3042 24.3042 0 0 0 0 0 0 A0A9Q1BW96 A0A9Q1BW96_HOLLE Ficolin-1 HOLleu_24130 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.2 1.0179 -2.2078 ESVAACSWKEGSECDNAGECNSM 0 0 0 0 0 0 21.8425 21.8527 21.8527 0 0 0 0 0 0 0 0 0 A0A9Q1BWD3 A0A9Q1BWD3_HOLLE UNC5C-like protein HOLleu_21413 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 0.4 0.91139 -0.068637 SSGAEMPP 21.059 0 0 0 0 0 0 0 0 0 20.3541 20.3541 0 0 0 0 0 0 A0A9Q1BWD6 A0A9Q1BWD6_HOLLE Ryncolin-4 HOLleu_24197 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.8 1.0169 -6.0779 WCHSCYGSHCSNIY 0 22.7311 22.7311 0 0 0 0 0 0 0 22.4914 22.4914 0 0 0 0 0 0 A0A9Q1BWE2 A0A9Q1BWE2_HOLLE SH3 domain-containing kinase-binding protein 1 HOLleu_21434 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin filament organization [GO:0007015]; cell migration [GO:0016477]; phosphorylation [GO:0016310]; signal transduction [GO:0007165] kinase activity [GO:0016301] 1 0.4 1.0011 -23.777 HFGWWEGE 0 17.9935 17.9935 0 0 0 17.8727 0 0 19.3179 0 0 0 0 0 0 0 0 A0A9Q1BWF2 A0A9Q1BWF2_HOLLE Ryncolin-2 HOLleu_24423 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 2.1 1.0028 -4.979 YCWDCNGSNY 0 25.2283 25.2283 0 15.9478 15.9478 0 0 0 25.0655 24.5577 24.5577 19.66 19.6781 19.6781 0 0 0 A0A9Q1BWF6 A0A9Q1BWF6_HOLLE Laminin subunit alpha-2 HOLleu_24403 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; membrane [GO:0016020] extracellular matrix structural constituent [GO:0005201]; signaling receptor binding [GO:0005102] 1 0.6 1.0015 -4.125 CKCNRHSTECEEGSGHCVNC 0 0 0 0 0 0 22.1544 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BWF9 A0A9Q1BWF9_HOLLE Tyrosine-protein kinase (EC 2.7.10.2) HOLleu_24163 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] 1 1.9 0.9 -0.068637 HYYMEEDG 0 0 0 0 0 0 0 0 0 24.2951 0 0 0 0 0 0 0 0 A0A9Q1BWI7 A0A9Q1BWI7_HOLLE Ficolin-1 HOLleu_24366 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 4.9 1.0088 -2.7235 KNVTCEPIQDTEVFTDCYHAY 0 26.4182 26.4182 0 0 0 0 0 0 0 0 0 0 17.7287 17.7287 0 0 0 A0A9Q1BWI8 A0A9Q1BWI8_HOLLE Angiopoietin-related protein 7 HOLleu_24459 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 5.6 0.9964 -34.837 KPYSGWCTACYYSYRYCDY;QIFCIYIIAFAF 0 25.1953 25.1953 0 0 0 18.8978 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BWJ7 A0A9Q1BWJ7_HOLLE Zonadhesin HOLleu_24341 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "blood coagulation, common pathway [GO:0072377]; fibrinolysis [GO:0042730]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; protein polymerization [GO:0051258]" fibrinogen complex [GO:0005577] extracellular matrix structural constituent [GO:0005201] 2 1.6 0.88889 -0.068637 CNDGYSGD;PNNCLPCA 22.7058 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BWL8 A0A9Q1BWL8_HOLLE Uncharacterized protein HOLleu_24381 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.9 0.58333 -0.068637 FCMNECGQ 24.0505 0 0 0 0 0 0 0 0 0 0 0 21.0373 0 0 0 0 0 A0A9Q1BWM0 A0A9Q1BWM0_HOLLE XK-related protein HOLleu_24513 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] 1 1.3 1.0226 -5.5496 MDCNPCEQQEP 19.4305 20.8266 20.8266 0 0 0 0 0 0 22.4884 20.8486 20.8486 17.7629 17.816 17.816 0 0 0 A0A9Q1BWM9 A0A9Q1BWM9_HOLLE Fibrinogen-like protein A HOLleu_24401 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 3.4 1.0099 -5.5027 YCTSGQFTCDNAYRCS 23.0162 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BWN0 A0A9Q1BWN0_HOLLE Angiopoietin-related protein 7 HOLleu_24441 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.7 0.96335 -0.17167 GCGSHDYAEGHSGGWWYTDNWCSGC 0 0 0 0 0 0 21.8271 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BWN3 A0A9Q1BWN3_HOLLE Tenascin-R HOLleu_24340 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.9 1.0062 -4.125 CEEPLGCHYNCTQPEACVCP 23.027 22.4408 22.4408 0 0 0 0 0 0 0 19.1542 19.1542 0 0 0 0 0 0 A0A9Q1BWN7 A0A9Q1BWN7_HOLLE Palmitoyltransferase (EC 2.3.1.225) HOLleu_21017 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi apparatus [GO:0005794]; membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] 1 2.7 1.0233 -23.631 ALCCDCQELDS 0 0 0 0 0 0 19.4845 18.5109 18.5109 0 0 0 17.7536 0 0 0 0 0 A0A9Q1BWP5 A0A9Q1BWP5_HOLLE Zinc finger protein PLAG1 HOLleu_24405 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694] chromatin insulator sequence binding [GO:0043035] 1 2.7 1.0031 -4.125 NDTNNNEAPSSSEPWKCSSC 0 0 0 0 0 0 0 23.7871 23.7871 0 0 0 0 0 0 0 0 0 A0A9Q1BWQ3 A0A9Q1BWQ3_HOLLE SET domain-containing protein HOLleu_20849 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.5 1.0089 -6.0779 EVCQPQNCPDEFQC 0 27.5252 27.5252 18.0577 21.5547 19.3901 0 0 0 28.9345 26.0241 26.0241 23.9546 0 0 17.7794 0 18.8747 A0A9Q1BWQ4 A0A9Q1BWQ4_HOLLE Fibrinogen-like protein A HOLleu_24379 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.4 1.0055 -2.5328 CSSRCSCTTGQFSCDDTYQCSP 0 0 0 0 0 0 26.0056 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BWQ8 A0A9Q1BWQ8_HOLLE Ryncolin-4 HOLleu_24342 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.8 1.008 -6.2493 FGYWCTYCYGYSN 20.957 22.5348 22.5348 0 0 0 19.3953 18.2339 18.5342 20.23 20.2834 20.2834 0 0 0 0 0 0 A0A9Q1BWR8 A0A9Q1BWR8_HOLLE Tesmin/TSO1-like CXC domain-containing protein HOLleu_24474 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 0.91463 -0.068637 PEPLLELR 0 27.2008 27.2008 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BWS0 A0A9Q1BWS0_HOLLE Polycomb protein Asx HOLleu_24514 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; positive regulation of transcription by RNA polymerase II [GO:0045944] PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975] 3 4.9 1.0018 -28.186 LKPLKPPEGGTNGTKEELRSSS;RKSGFVPRIIL;VKAAAAAAA 0 0 0 18.5303 0 0 0 18.2055 18.2055 0 0 0 0 0 0 16.7837 0 0 A0A9Q1BWV6 A0A9Q1BWV6_HOLLE Ficolin-1 HOLleu_24439 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 1.0049 -4.979 RTCDNNYQCD 17.4899 18.3149 18.3149 0 0 0 0 0 0 21.9085 0 0 0 0 0 0 0 0 A0A9Q1BWW9 A0A9Q1BWW9_HOLLE Uncharacterized protein HOLleu_21146 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.0153 -6.0118 VESEEMDTSDED 0 0 0 0 0 0 0 0 0 0 22.791 22.791 0 0 0 0 0 0 A0A9Q1BWZ9 A0A9Q1BWZ9_HOLLE Amyloid-beta-like protein HOLleu_21217 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axonogenesis [GO:0007409]; central nervous system development [GO:0007417] membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025] heparin binding [GO:0008201]; transition metal ion binding [GO:0046914] 1 1.1 1.0074 -6.2493 SSSEEEDEEEEDI 0 0 0 0 0 0 0 22.7862 22.7862 0 0 0 0 0 0 0 0 0 A0A9Q1BX07 A0A9Q1BX07_HOLLE Uncharacterized protein HOLleu_21896 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.2 1.0141 -6.0118 LQEEHRKVVWDK 23.9449 25.9306 25.9306 0 0 0 20.3539 0 20.2585 0 0 0 20.6057 0 0 0 0 0 A0A9Q1BX70 A0A9Q1BX70_HOLLE Rho GTPase-activating protein 32 HOLleu_21095 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) small GTPase-mediated signal transduction [GO:0007264] GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091] 2 1.3 1.0037 -25.951 PPPRRKKG;VVLRRAPA 18.9872 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BX71 A0A9Q1BX71_HOLLE Uncharacterized protein HOLleu_22068 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.4 0.96569 -0.1989 VCSMENEECVN 0 24.1029 24.1029 0 0 0 0 20.7007 20.7007 21.1682 17.3623 17.3623 0 0 0 0 0 0 A0A9Q1BX81 A0A9Q1BX81_HOLLE Myosin-11 HOLleu_22087 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] chitin binding [GO:0008061] 2 0.4 1.0088 -6.8678 EDCVECDPGFYCQYAG;QWGQNPQPC 21.8786 21.308 21.308 0 0 0 0 0 0 20.453 20.552 20.552 0 0 0 0 0 0 A0A9Q1BXD1 A0A9Q1BXD1_HOLLE Multiple epidermal growth factor-like domains protein 8 HOLleu_21194 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 2 2.3 1.0192 -2.6427 QECFCMDNTMG;TMGERCDQC 0 24.5287 24.5287 0 19.2162 0 0 18.8162 0 0 24.6245 24.6245 0 21.0336 21.0336 0 0 0 A0A9Q1BXF0 A0A9Q1BXF0_HOLLE C2H2-type domain-containing protein HOLleu_21572 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 0.9 1.0251 -23.631 THTCERPFKCQ 0 0 0 0 0 0 0 0 0 0 18.7702 18.7702 0 0 0 0 0 0 A0A9Q1BXF2 A0A9Q1BXF2_HOLLE SRCR domain-containing protein HOLleu_21535 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 4.5 1.0135 -6.0118 DGEWGGVCTDGW 0 0 0 0 0 0 23.2269 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BXF7 A0A9Q1BXF7_HOLLE Uncharacterized protein HOLleu_21150 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 1.0171 -5.7538 DDQYPEGCKLDFFWC 0 0 0 0 0 0 0 0 0 23.0526 0 0 0 0 0 0 0 0 A0A9Q1BXG8 A0A9Q1BXG8_HOLLE Neurogenic locus Notch protein HOLleu_21110 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 2 3.2 1.0079 -6.3328 CDSSPCQNGATCYNSYSSDSPEQ;EGSCTQTFCECQQCTRGDLC 0 24.9017 24.9017 0 0 0 0 0 0 27.4118 0 0 0 0 0 0 0 0 A0A9Q1BXK7 A0A9Q1BXK7_HOLLE hydroxymethylbilane synthase (EC 2.5.1.61) (Hydroxymethylbilane synthase) HOLleu_21352 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heme biosynthetic process [GO:0006783] cytoplasm [GO:0005737] hydroxymethylbilane synthase activity [GO:0004418] 1 2.3 0.90476 -0.068637 LLKHAHKH 19.3866 21.4334 21.4334 0 0 0 0 0 0 21.646 21.6304 21.6304 0 0 0 0 0 0 A0A9Q1BXL5 A0A9Q1BXL5_HOLLE Uncharacterized protein HOLleu_21402 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 21.4 1.0048 -26.398 CCSYPNIKTC;CDCACQPPECETIDCLCFKMQ 0 0 0 0 0 0 0 24.0453 24.0453 0 0 0 17.2793 18.4025 18.4025 0 0 0 A0A9Q1BXM6 A0A9Q1BXM6_HOLLE EGF-like domain-containing protein HOLleu_21522 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4.1 1.0056 -8.5446 CEDGYERNDEGECEHTTPTCND;DTDKDETCESEG 0 22.0174 22.0174 22.3572 21.3404 21.3404 0 0 0 23.7203 23.0757 23.0757 0 20.7613 20.7613 0 0 0 A0A9Q1BXP5 A0A9Q1BXP5_HOLLE Hemicentin-1 HOLleu_21609 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046] 1 1.1 1.0178 -23.723 LRKTDRGIY 18.1139 20.4596 20.4596 0 0 0 0 0 0 21.6356 21.9111 21.9111 0 19.6306 19.6306 0 0 0 A0A9Q1BXQ8 A0A9Q1BXQ8_HOLLE Fibroblast growth factor receptor 3 HOLleu_21485 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of apoptotic process [GO:0042981] membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein tyrosine kinase activity [GO:0004713] 1 1.3 1.0227 -23.723 PNNEGNYTC 0 0 0 0 0 0 0 0 0 0 0 0 16.4356 17.0235 17.0235 0 0 0 A0A9Q1BXR7 A0A9Q1BXR7_HOLLE C2H2-type domain-containing protein HOLleu_21504 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0031 -23.777 YRHQMYFC 0 0 0 0 0 0 0 0 0 0 0 0 16.7963 0 0 0 0 0 A0A9Q1BXS7 A0A9Q1BXS7_HOLLE MAM and LDL-receptor class A domain-containing protein 2 HOLleu_21631 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.3 1.0008 -4.564 DVEDEGDCSDVEYSCTDGT 0 0 0 0 0 0 24.8736 24.502 24.502 0 0 0 0 0 0 0 0 0 A0A9Q1BXU0 A0A9Q1BXU0_HOLLE Netrin receptor UNC5B HOLleu_21435 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0293 -23.442 LNRISPFMREMI 0 0 0 0 0 0 0 0 0 0 22.202 22.202 0 0 0 0 0 0 A0A9Q1BXU2 A0A9Q1BXU2_HOLLE ZU5 domain-containing protein HOLleu_21520 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 1.0074 -6.2493 PFIFLKKGKKPLT 20.7892 22.1424 22.1424 0 0 0 0 0 19.6852 21.5009 0 0 19.9393 19.808 19.808 0 0 0 A0A9Q1BXV1 A0A9Q1BXV1_HOLLE Neurotrypsin HOLleu_21541 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] chitin binding [GO:0008061] 3 6.1 1.0102 -14.326 SCCSPNGWCGYSPDDCTCD;SESGWCGNSTDNCTCDGCIDYR;STDNCTCDGC 25.5487 0 0 0 0 0 0 0 0 0 26.9458 26.9458 19.746 0 0 0 0 0 A0A9Q1BXW3 A0A9Q1BXW3_HOLLE NACHT domain-containing protein HOLleu_21417 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 1 1.0114 -11.621 AEPEPDCFEDESIDTMLS 0 0 0 0 0 0 20.209 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BXW7 A0A9Q1BXW7_HOLLE Ig-like domain-containing protein HOLleu_21480 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; membrane [GO:0016020] 1 0.8 0.87356 -0.068637 HIVVKKTT 0 0 0 0 0 0 0 0 0 0 0 0 22.3582 0 0 0 0 0 A0A9Q1BXZ2 A0A9Q1BXZ2_HOLLE DNA polymerase epsilon catalytic subunit (EC 2.7.7.7) HOLleu_22704 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "base-excision repair, gap-filling [GO:0006287]; DNA replication proofreading [GO:0045004]; leading strand elongation [GO:0006272]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair, DNA gap filling [GO:0006297]" epsilon DNA polymerase complex [GO:0008622] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; zinc ion binding [GO:0008270]" 2 1 1.0149 -21.993 NMTRYCECAGDFETT;PLKFPDAE 19.3056 0 0 0 0 0 0 0 0 22.9447 0 0 0 0 0 0 0 0 A0A9Q1BXZ4 A0A9Q1BXZ4_HOLLE BRCT domain-containing protein HOLleu_21680 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0064 -2.5328 VRKAKLNGKVTKRKRTRFAKLL 0 21.688 21.688 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BY00 A0A9Q1BY00_HOLLE N-lysine methyltransferase KMT5A HOLleu_21758 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] methyltransferase activity [GO:0008168] 1 1.3 1.0159 -21.924 SSNGGNESNSNDGGG 0 20.4172 20.4172 0 0 0 0 0 0 18.1619 16.7568 16.7568 0 0 0 0 0 0 A0A9Q1BY34 A0A9Q1BY34_HOLLE Carboxylic ester hydrolase (EC 3.1.1.-) HOLleu_21922 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695] extracellular space [GO:0005615]; plasma membrane [GO:0005886] acetylcholinesterase activity [GO:0003990] 1 1.3 1.0023 -23.777 GGDNDGNN 20.2463 20.8305 20.8305 0 0 0 21.929 22.1416 22.1416 0 0 0 0 0 0 0 0 0 A0A9Q1BY40 A0A9Q1BY40_HOLLE Leucine-rich repeat-containing protein 58 HOLleu_21658 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 3.4 1.0054 -6.2493 CYSPCPSSSSSSS 0 26.1589 26.1589 0 0 0 0 0 0 0 24.3278 24.3278 0 0 0 0 0 0 A0A9Q1BY50 A0A9Q1BY50_HOLLE CCHC-type domain-containing protein HOLleu_21584 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 5.5 1.0054 -4.125 GNNSDSSDSYSESTCDFEDR 21.5476 21.9757 21.9757 0 0 0 0 0 0 22.5912 0 0 0 17.4393 17.4393 0 0 0 A0A9Q1BY51 A0A9Q1BY51_HOLLE Uncharacterized protein HOLleu_22086 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.0171 -5.7538 CEGGYYTNITGQASC 0 0 0 0 0 0 24.2054 23.9068 23.9068 0 0 0 0 17.6348 17.6348 0 0 0 A0A9Q1BY54 A0A9Q1BY54_HOLLE Neurotrypsin HOLleu_21681 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 1.4 1.0015 -23.777 YFGQGNGS 21.6486 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BY55 A0A9Q1BY55_HOLLE Ig-like domain-containing protein HOLleu_22159 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.1 1.0197 -23.723 HCEAEDNFH 0 18.2442 18.2442 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BY56 A0A9Q1BY56_HOLLE Multiple epidermal growth factor-like domains protein 6 HOLleu_19267 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] membrane [GO:0016020] scavenger receptor activity [GO:0005044] 11 12.8 0.99506 -82.465 CDCSQNTSLCDKETGECLCFPGW;CGGQCSCQNGASC;CNQSCNCQN;GSCDCPEGFHGNSCEDVCSGGRYG;GYWGHGCSNMCDCVNGTCN;MCNLQCPNGTYGSGCSQTCLCPD;MDCSTQCHDGLYGENCLGICHCE;PLCDQECDCGV;SCSPYDGHCTC;TDVFNCSQGCTCENGGTCNH;VHGTCNSVDGSCECN 0 24.5544 24.5544 0 0 0 25.2119 23.8483 23.8483 22.106 20.1292 20.1292 18.1959 16.9947 16.9947 0 0 0 A0A9Q1BY71 A0A9Q1BY71_HOLLE Cubilin HOLleu_19309 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 0.5 0.99851 -4.564 YCGNCPSGYTGNGKQCSDV 0 0 0 0 0 0 0 0 0 0 21.6997 21.6997 0 0 0 0 0 0 A0A9Q1BY88 A0A9Q1BY88_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_22251 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; phosphorylation [GO:0016310] kinase activity [GO:0016301]; scavenger receptor activity [GO:0005044] 1 1.2 1.0011 -23.777 YYSIDGDG 0 0 0 0 0 0 0 0 0 18.4637 0 0 0 0 0 0 0 0 A0A9Q1BY98 A0A9Q1BY98_HOLLE Tyr recombinase domain-containing protein HOLleu_21977 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677] 2 4.9 1.004 -2.7113 AHSTRAAAA;HSTRAAAA 0 24.854 24.854 0 0 0 0 0 0 0 0 0 0 21.0289 21.0289 0 0 0 A0A9Q1BYA8 A0A9Q1BYA8_HOLLE Uncharacterized protein HOLleu_19384 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 13.8 1.0175 -23.027 GGNAASNTNDECY 0 0 0 0 0 0 0 0 0 19.0322 0 0 0 0 0 0 0 0 A0A9Q1BYC6 A0A9Q1BYC6_HOLLE Ig-like domain-containing protein HOLleu_22047 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 2 1 -5.0842 VIKIIIIVAV;VLLTRILISRR 0 0 0 14.6004 15.7098 15.7098 16.8835 15.3051 15.3051 0 0 0 0 15.1472 15.1472 0 0 0 A0A9Q1BYD3 A0A9Q1BYD3_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_21940 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 1 1.4 1.0037 -6.2493 FDECMDTSDESMV 0 22.6791 22.6791 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BYF1 A0A9Q1BYF1_HOLLE Gustatory receptor HOLleu_21916 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sensory perception of taste [GO:0050909] membrane [GO:0016020] 1 3 1.0145 -5.7538 TVSWDEEEDDGIYDE 0 0 0 0 0 0 0 21.4935 21.4935 0 0 0 0 0 0 0 0 0 A0A9Q1BYG6 A0A9Q1BYG6_HOLLE Paired box protein Pax-6 HOLleu_22426 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 3 5.6 1.013 -11.323 DFCFDDDDEH;HEDFCFDDDD;YSYGILELE 0 0 0 0 0 0 0 0 0 0 0 0 24.3965 25.117 25.117 0 0 0 A0A9Q1BYI6 A0A9Q1BYI6_HOLLE Ig-like domain-containing protein HOLleu_22173 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.8 1.0004 -23.777 KYYFSWRS 0 0 0 0 0 0 0 0 0 20.8384 0 0 0 0 0 0 0 0 A0A9Q1BYJ1 A0A9Q1BYJ1_HOLLE ZU5 domain-containing protein HOLleu_21843 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1.3 1.002 -5.0477 IPLLFVLVVH;YWPYDMTA 0 0 0 0 0 0 0 21.2429 21.2429 24.6127 25.2236 25.2236 21.5937 22.2226 22.2226 0 0 0 A0A9Q1BYK0 A0A9Q1BYK0_HOLLE Tyrosine kinase receptor Cad96Ca HOLleu_22075 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 3 5.4 1.0092 -7.9249 DCENEGNCN;MIIIIIVGPAVLAVLIF;QCINNSDCENEGNCNNGNC 23.7192 0 0 0 0 0 0 23.3852 23.3852 0 0 0 0 0 0 0 0 16.0936 A0A9Q1BYK3 A0A9Q1BYK3_HOLLE Uncharacterized protein HOLleu_22328 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.6 1.016 -2.6427 MEPNLDPAC 0 0 0 0 0 0 0 0 0 0 0 0 23.9747 0 0 0 0 0 A0A9Q1BYK6 A0A9Q1BYK6_HOLLE Coiled-coil domain-containing protein 84 HOLleu_22433 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 0.92045 -0.068637 MADDYYCE 0 0 0 0 0 0 0 0 0 0 21.2318 21.2318 0 0 0 0 0 0 A0A9Q1BYQ2 A0A9Q1BYQ2_HOLLE Golgin subfamily A member 4 HOLleu_22425 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576]; membrane [GO:0016020] chitin binding [GO:0008061] 8 1.2 0.9961 -52.814 CQICPDGYYCYP;CWEGYYCSWGTG;GEWTCDTCPAGY;HNYTDLCDEGWYCSGGASSSNT;PPGTYTGATDLTAAEECSPCW;SGECYAGYYCPE;SGGTPGMY;TMLCEEGYWCDS 0 23.9071 23.9071 21.6388 22.1405 22.1405 21.3444 23.2792 23.2792 23.437 23.4057 23.4057 0 0 0 0 0 0 A0A9Q1BYQ4 A0A9Q1BYQ4_HOLLE Cell adhesion molecule 2 HOLleu_22324 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3 1.0162 -22.715 LPKIHWFIQNHDNF 0 0 0 0 0 0 0 0 0 17.8348 0 0 0 0 0 0 0 0 A0A9Q1BYV6 A0A9Q1BYV6_HOLLE Centrosomal protein POC5 (Protein of centriole 5) HOLleu_19776 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell cycle [GO:0007049] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] 1 1.5 0.91011 -0.068637 ASHGPSRG 18.6862 20.111 20.111 0 0 0 0 0 0 21.2239 0 0 16.9804 17.599 17.599 0 0 0 A0A9Q1BZ33 A0A9Q1BZ33_HOLLE Bromodomain adjacent to zinc finger domain protein 2B HOLleu_19335 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] 4 2 1.0103 -7.5468 GTRERVLHRSLTKHTEFIKKILSK;RERVLHRSLTKHTEFIKK;RKEKKKKRKKKK;RRKQHLVLVRAL 23.2471 25.278 25.278 0 0 0 0 0 0 23.2953 27.2059 27.2059 20.973 20.7084 20.7084 0 0 0 A0A9Q1BZ59 A0A9Q1BZ59_HOLLE Collagen alpha-2(I) chain HOLleu_19376 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] 1 0.2 1.0023 -23.777 GRDGDPGP 0 0 0 0 0 0 0 19.1459 19.1459 0 0 0 0 0 0 0 0 0 A0A9Q1BZA0 A0A9Q1BZA0_HOLLE Cell adhesion molecule 3 HOLleu_22340 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of B cell receptor signaling pathway [GO:0050859]; regulation of B cell proliferation [GO:0030888] early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; recycling endosome [GO:0055037] CD4 receptor binding [GO:0042609]; protein phosphatase binding [GO:0019903]; sialic acid binding [GO:0033691] 1 3 1.027 -23.027 IGGTSLFKCSLHV 0 0 0 0 0 0 0 0 0 0 0 0 0 19.4931 19.4931 0 0 0 A0A9Q1BZA4 A0A9Q1BZA4_HOLLE Chitin-binding type-1 domain-containing protein HOLleu_22747 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chitin binding [GO:0008061] 1 7.9 1.0064 -2.5328 SPCCSDVGWCGSTSDHCNCPKC 24.7098 23.6635 23.6635 0 0 0 0 0 0 17.8563 0 0 0 0 0 0 0 0 A0A9Q1BZB9 A0A9Q1BZB9_HOLLE Ig-like domain-containing protein HOLleu_22584 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 2.4 0.99745 -29.721 PKINVCDSCE;TPSPPCPKINVCDSCEECSKATVT 0 0 0 0 0 0 0 0 0 0 18.6517 18.6517 0 0 0 0 0 0 A0A9Q1BZC0 A0A9Q1BZC0_HOLLE Ig-like domain-containing protein HOLleu_22384 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.3 0.066667 -0.068637 DNWDPYEL 0 23.3061 23.3061 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BZE2 A0A9Q1BZE2_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_22685 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.7 1.0162 -5.5496 HDVATEEGSDD 0 0 0 0 0 0 0 21.5663 21.5663 0 0 0 0 0 0 0 0 0 A0A9Q1BZF3 A0A9Q1BZF3_HOLLE Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) HOLleu_22558 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843] 2 2.6 0.99485 -0.46718 ILVIHLKRFS;VTALNHRR 24.875 0 0 0 0 0 0 0 0 0 0 0 19.353 19.6719 19.6719 0 0 0 A0A9Q1BZG1 A0A9Q1BZG1_HOLLE Uncharacterized protein HOLleu_20159 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.5 0.89011 -0.068637 SHQGGGDG 16.9368 27.0826 27.0826 0 0 0 21.7599 0 0 20.5641 0 0 0 21.8059 21.8059 0 0 0 A0A9Q1BZG4 A0A9Q1BZG4_HOLLE Collagen alpha-1(XXIV) chain HOLleu_22579 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581] 6 27.2 1.0077 -7.9837 DDGDDGDD;DGDDDDDDDGDDGDE;EDEDEDDD;GDDGDDGDEGDVDDH;GDDGDDGDEGDVDDHG;GDVDDHGGDGDDGDDGDDGDDG 0 22.8972 22.8972 0 17.1697 0 16.8437 16.2263 16.2263 22.8526 22.691 22.691 19.917 19.7569 19.7569 0 0 0 A0A9Q1BZI3 A0A9Q1BZI3_HOLLE Protein SSUH2-like HOLleu_19223 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4 1.0007 -47.5 DRCTSCGG;RCSSCHGSG 0 19.8371 19.8371 19.612 19.0583 19.0583 0 0 0 0 18.2829 18.2829 0 0 0 16.6352 0 0 A0A9Q1BZI8 A0A9Q1BZI8_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_22723 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.9 1.027 -23.723 DDDPWNDAD 20.6996 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BZJ4 A0A9Q1BZJ4_HOLLE Transient receptor potential cation channel subfamily M member 2 HOLleu_22517 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] ligand-gated calcium channel activity [GO:0099604] 1 3.2 1.0149 -5.8824 PKLIMINRMMQDMLFFLCLLI 0 21.5244 21.5244 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1BZJ6 A0A9Q1BZJ6_HOLLE MANSC domain-containing protein HOLleu_19351 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.9 1.0011 -23.777 WADCQGFC 0 18.0409 18.0409 0 0 0 0 0 0 17.7061 0 0 0 0 0 0 0 0 A0A9Q1BZL9 A0A9Q1BZL9_HOLLE Protein C21orf2 HOLleu_20276 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA splicing, via spliceosome [GO:0000398]; outer dynein arm assembly [GO:0036158]" cytoplasm [GO:0005737]; U4/U6 x U5 tri-snRNP complex [GO:0046540] 2 5.7 1.0226 -1.4337 PKLKVLWLA;VLKMLPNL 0 0 0 0 0 0 23.9068 0 0 0 0 0 0 24.3536 24.3536 0 0 0 A0A9Q1BZM1 A0A9Q1BZM1_HOLLE Mucin-like protein HOLleu_19470 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 2 2.4 1.0103 -7.7574 ACVCNSGFMGDGFSCENVNECEE;TCFNTNGSYDC 19.9919 20.6847 20.6847 15.793 0 0 20.8866 20.7187 20.7187 0 22.1623 22.1623 18.6128 18.8859 18.8859 0 0 0 A0A9Q1BZN0 A0A9Q1BZN0_HOLLE Ig-like domain-containing protein HOLleu_22722 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] protein tyrosine kinase activity [GO:0004713] 1 1.2 0.87179 -0.068637 NDGGMYRC 17.7554 0 0 0 0 0 0 0 0 22.5104 21.8439 21.8439 18.3959 18.7415 18.7415 0 0 0 A0A9Q1BZQ1 A0A9Q1BZQ1_HOLLE Eukaryotic translation initiation factor 3 subunit A HOLleu_19215 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) formation of cytoplasmic translation initiation complex [GO:0001732]; translation reinitiation [GO:0002188] "eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; multi-eIF complex [GO:0043614]" mRNA binding [GO:0003729]; translation initiation factor activity [GO:0003743] 1 3.5 1.0209 -23.723 KIPCRKEDY 0 0 0 0 0 0 0 0 0 19.8131 0 0 0 0 0 0 0 0 A0A9Q1BZR9 A0A9Q1BZR9_HOLLE Methionine synthase reductase (EC 1.16.1.8) HOLleu_19564 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086] cytosol [GO:0005829] [methionine synthase] reductase activity [GO:0030586]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181] 1 1.2 1.0127 -2.6427 TPPKKAFLR 0 20.4717 20.4717 0 0 0 20.0718 0 20.8044 22.8788 21.784 21.784 0 20.8653 20.8653 0 0 0 A0A9Q1BZS2 A0A9Q1BZS2_HOLLE Indian hedgehog protein HOLleu_19251 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; smoothened signaling pathway [GO:0007224]; system development [GO:0048731] extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; transferase activity [GO:0016740] 1 3.7 1.0288 -23.442 LNLLPSIGWSET 0 0 0 17.9188 0 0 0 20.2255 20.2255 0 0 0 0 0 0 0 0 17.5653 A0A9Q1BZX1 A0A9Q1BZX1_HOLLE Macrophage mannose receptor 1 HOLleu_19422 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] signaling receptor activity [GO:0038023] 2 1.4 1.0096 -10.482 GEWQSDGDSCYLFRME;YEWEDGQTYD 0 0 0 0 0 0 0 0 0 22.9486 0 0 0 0 0 0 0 0 A0A9Q1BZY0 A0A9Q1BZY0_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_19601 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] kinase activity [GO:0016301] 1 9.1 1.0137 -5.8824 CDMSCDANCGDGKGVCDDVDG 0 0 0 0 0 0 18.1655 20.8013 20.8013 0 0 0 0 0 0 0 0 0 A0A9Q1BZZ7 A0A9Q1BZZ7_HOLLE Agrin HOLleu_19937 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] 1 3.9 1.0042 -6.2493 YHSPVCGSDGETY 0 0 0 0 0 0 0 0 0 0 0 0 21.7636 21.9681 21.9681 0 0 0 A0A9Q1C023 A0A9Q1C023_HOLLE FK506-binding protein 4 HOLleu_19763 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 1.0127 -2.6427 EEDYYGDFD 23.833 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C024 A0A9Q1C024_HOLLE Pogo transposable element with ZNF domain HOLleu_19925 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" 1 0.5 1.022 -5.5496 NTMDCNGNSWA 25.0054 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C046 A0A9Q1C046_HOLLE Centromere-associated protein E HOLleu_19810 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] 1 0.5 1.0015 -23.777 SSSGGSDG 17.7526 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C056 A0A9Q1C056_HOLLE ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) HOLleu_19825 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) innate immune response [GO:0045087]; NAD catabolic process [GO:0019677]; signal transduction [GO:0007165] NAD+ nucleosidase activity [GO:0003953] 2 4.5 1.0041 -24.697 LFKSNSVWYPANYCYNVVW;VKASLSILHNLS 16.4986 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13.6147 0 0 A0A9Q1C089 A0A9Q1C089_HOLLE Limb region 1 protein-like HOLleu_19446 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] 1 1.6 0.84615 -0.068637 YSSDAEDA 0 24.1831 24.1831 0 0 0 0 0 0 25.8563 0 0 0 0 0 0 0 0 A0A9Q1C096 A0A9Q1C096_HOLLE Acidic leucine-rich nuclear phosphoprotein 32 family member A HOLleu_19465 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of apoptotic process [GO:0042981] nucleus [GO:0005634] histone binding [GO:0042393] 2 8.8 1.0045 -2.6014 PDEDADDA;PEEDDEDEEDFNPDEEDGDEED 23.3645 0 0 0 0 0 0 0 0 21.458 19.4482 19.4482 0 16.9203 16.9203 0 0 0 A0A9Q1C0B9 A0A9Q1C0B9_HOLLE exodeoxyribonuclease III (EC 3.1.11.2) HOLleu_19619 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) base-excision repair [GO:0006284] nucleus [GO:0005634] DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081] 1 4.6 0.83333 -0.068637 ADVGYGGS 19.8502 21.0617 21.0617 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C0E5 A0A9Q1C0E5_HOLLE Uncharacterized protein HOLleu_19686 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 8.5 1.0068 -24.177 GDDDDDDDDGDDDYDDDDDDDDED;NDGDDDEEDDY;QNDDDDDDN 0 0 0 0 16.634 0 0 0 0 23.666 22.3702 22.3702 18.7622 0 0 0 0 0 A0A9Q1C0F3 A0A9Q1C0F3_HOLLE Enhancer of polycomb-like protein HOLleu_19778 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell cycle [GO:0007049]; DNA repair [GO:0006281]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; piccolo histone acetyltransferase complex [GO:0032777] 3 3.1 1.0041 -26.019 RPVHKQLS;RRRIGRGG;SRLPLLPP 0 0 0 23.7756 0 0 0 0 0 19.8256 19.7739 19.7739 16.7291 0 0 0 23.1975 23.1975 A0A9Q1C0G0 A0A9Q1C0G0_HOLLE Serine protease inhibitor dipetalogastin HOLleu_20246 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] 1 1.8 1.0056 -2.7235 SDGQTYSNMCQFENAVCENPE 0 0 0 0 0 0 0 0 0 0 22.1734 22.1734 0 0 0 0 0 0 A0A9Q1C0K4 A0A9Q1C0K4_HOLLE Hyalin HOLleu_19875 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 6.5 1.0033 -27.279 ATCTDNSGSEDLTISCDDA;GETLSLEDSGEEVT 0 21.5557 21.5557 0 0 0 21.951 21.6701 21.6701 0 0 0 0 0 0 15.6007 0 16.5137 A0A9Q1C0N3 A0A9Q1C0N3_HOLLE proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) HOLleu_20113 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) NADPH regeneration [GO:0006740]; proton transmembrane transport [GO:1902600] mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886] NAD(P)+ transhydrogenase activity [GO:0008746]; NADP binding [GO:0050661] 1 0.8 0.83582 -0.068637 PVAGRMPG 0 0 0 0 0 0 0 0 0 22.5988 0 0 0 0 0 0 0 0 A0A9Q1C0N6 A0A9Q1C0N6_HOLLE Thrombospondin type-1 domain-containing protein 7A HOLleu_20349 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 1 0.6 1.0242 -23.675 WGECQGSSDC 0 17.8504 17.8504 0 0 0 0 0 0 0 19.0223 19.0223 0 0 0 0 0 0 A0A9Q1C0P9 A0A9Q1C0P9_HOLLE Fibrillin-1 HOLleu_20442 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 1.4 1.0066 -5.3628 DTEDCQNMIGSYMCDCKAGFSRQ 0 22.8595 22.8595 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C0S0 A0A9Q1C0S0_HOLLE Succinate dehydrogenase assembly factor 3 (SDH assembly factor 3) (SDHAF3) HOLleu_20045 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial respiratory chain complex II assembly [GO:0034553]; succinate metabolic process [GO:0006105] mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759] 1 6.8 0.82353 -0.068637 RRHKKVGP 0 0 0 0 0 0 0 0 0 0 0 0 19.5972 21.53 21.53 0 0 0 A0A9Q1C0S2 A0A9Q1C0S2_HOLLE Carboxylic ester hydrolase (EC 3.1.1.-) HOLleu_19781 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695] extracellular space [GO:0005615]; plasma membrane [GO:0005886] acetylcholinesterase activity [GO:0003990] 1 1.3 1.0019 -23.777 FHCPAEHT 0 0 0 0 0 0 0 0 0 0 0 0 0 18.5857 18.5857 0 0 0 A0A9Q1C0T1 A0A9Q1C0T1_HOLLE Multiple epidermal growth factor-like domains protein 6 HOLleu_20183 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 3 1.0247 -23.675 EDEDEDDD;WGCRQRCNCP 0 0 0 0 0 0 0 0 0 0 18.3269 18.3269 0 0 0 0 0 0 A0A9Q1C0U2 A0A9Q1C0U2_HOLLE Matrilin-3 HOLleu_20204 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 1 1.0118 -2.6427 CECTSCNQP 0 0 0 0 0 0 0 0 0 0 22.0834 22.0834 17.1949 19.8288 19.8288 0 0 0 A0A9Q1C0U7 A0A9Q1C0U7_HOLLE Defense protein 3 HOLleu_19946 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1 1.0165 -5.7538 EYTTDEMETTSEDFT 0 22.8147 22.8147 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C0V1 A0A9Q1C0V1_HOLLE Acyl-CoA-binding domain-containing protein 5 HOLleu_20042 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid metabolic process [GO:0006631] cytoplasm [GO:0005737]; membrane [GO:0016020] fatty-acyl-CoA binding [GO:0000062] 1 4.4 0.99559 -4.7869 DLAGDEASSSSGTEDEFC 21.8884 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C0V8 A0A9Q1C0V8_HOLLE WAP domain-containing protein HOLleu_19963 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] 1 6.2 0.81429 -0.068637 DDDDDDDDEEEREEEEEEEEEEAED 20.7435 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C0W5 A0A9Q1C0W5_HOLLE Latent-transforming growth factor beta-binding protein 4 HOLleu_20582 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 1.6 1.014 -16.819 GTTGPCDDFDECVSGTD 19.5079 20.22 20.22 0 0 0 0 0 0 20.6424 0 0 0 0 0 0 0 0 A0A9Q1C0Z6 A0A9Q1C0Z6_HOLLE Death domain-containing protein HOLleu_20066 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 1.2 1.0028 -4.979 PETEEVCQDY 21.1645 21.3018 21.3018 0 17.469 0 0 0 0 23.2034 22.9098 22.9098 18.6667 19.1093 19.1093 0 0 0 A0A9Q1C104 A0A9Q1C104_HOLLE Adhesion G-protein coupled receptor G6 HOLleu_20397 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 2 4.2 1.0208 -21.349 GSSGGNNQESDQTNNNGTDQ;NASLNTEIYETESDDG 0 0 0 0 0 0 18.8565 0 0 0 0 0 0 23.9968 23.9968 0 0 0 A0A9Q1C106 A0A9Q1C106_HOLLE Carboxylic ester hydrolase (EC 3.1.1.-) HOLleu_20335 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholinesterase activity [GO:0004104] 1 1.6 1.0106 -2.6427 DNDTYDFFD 0 21.1986 21.1986 0 0 0 0 0 0 0 0 0 16.297 0 0 0 0 0 A0A9Q1C107 A0A9Q1C107_HOLLE F-box/LRR-repeat protein 4 HOLleu_20678 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] 1 0.9 1.0028 -4.979 PSDGDDLEEK 0 20.6722 20.6722 0 0 0 0 0 0 22.2074 17.4514 17.4514 0 0 0 0 0 0 A0A9Q1C148 A0A9Q1C148_HOLLE Tesmin/TSO1-like CXC domain-containing protein HOLleu_20166 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.5 1.0213 -23.723 LRLLRQKVF 0 0 0 0 0 0 17.6665 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C157 A0A9Q1C157_HOLLE Protein LTV1 homolog HOLleu_20144 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056] "cytosol [GO:0005829]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" 1 1.9 1.0133 -2.6427 GEEEDRYEM 0 0 0 0 0 0 22.8701 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C167 A0A9Q1C167_HOLLE Uncharacterized protein HOLleu_20808 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1 1.0142 -2.6427 ILLHLVATT 0 0 0 0 0 0 0 0 0 0 21.181 21.181 20.0194 19.8269 19.8269 0 0 0 A0A9Q1C182 A0A9Q1C182_HOLLE Semaphorin-5B HOLleu_20225 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axon guidance [GO:0007411]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] membrane [GO:0016020] chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215] 1 1.6 1.0094 -6.0779 NNPAPQNGGQECEG 0 0 0 0 0 0 0 21.5377 21.5377 0 0 0 0 0 0 0 0 0 A0A9Q1C1A8 A0A9Q1C1A8_HOLLE mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (EC 3.2.1.96) HOLleu_17401 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metabolic process [GO:0008152] cytosol [GO:0005829] mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925] 1 1.3 1.011 -2.6427 DGCNGGGCM 0 21.5628 21.5628 0 0 0 0 0 0 20.4948 20.0358 20.0358 0 0 0 0 0 0 A0A9Q1C1B6 A0A9Q1C1B6_HOLLE Hyalin HOLleu_20395 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.9 1.0174 -5.7538 QCNCTDISGNTEQCS 0 0 0 0 0 0 0 0 0 0 21.5768 21.5768 0 0 0 0 0 0 A0A9Q1C1C6 A0A9Q1C1C6_HOLLE Uncharacterized protein HOLleu_17435 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.3 1 -4.564 ACMYSQQEYNDESESESDF 0 0 0 0 0 0 0 22.4578 22.4578 0 0 0 0 0 0 0 0 0 A0A9Q1C1F5 A0A9Q1C1F5_HOLLE Uncharacterized protein HOLleu_17486 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 15.8 1.0247 -23.723 GESCSDFFG 0 0 0 0 0 0 19.5159 19.3566 19.3566 0 0 0 0 0 0 0 0 0 A0A9Q1C1F6 A0A9Q1C1F6_HOLLE Endoplasmic reticulum membrane sensor NFE2L1 HOLleu_20483 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.7 1.0252 -23.027 DGMADNNEMDSDM 0 0 0 18.9799 17.816 17.816 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C1F9 A0A9Q1C1F9_HOLLE Uncharacterized protein HOLleu_20182 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 2.1 0.98614 -0.20876 KKRSKKKKKKKSRKRKKKDREKEH 19.5896 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C1G8 A0A9Q1C1G8_HOLLE phospholipase A2 (EC 3.1.1.4) HOLleu_18222 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cardiolipin acyl-chain remodeling [GO:0035965]; positive regulation of ceramide biosynthetic process [GO:2000304] mitochondrion [GO:0005739] calcium-independent phospholipase A2 activity [GO:0047499] 1 1.5 1.0166 -6.0118 EYPHDPQEECEY 0 23.9071 23.9071 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C1I4 A0A9Q1C1I4_HOLLE Neurogenic locus notch-like protein 1 HOLleu_20769 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 0.7 1.0151 -2.6427 ECNNGTCED 0 0 0 0 19.6081 0 0 0 0 0 0 0 23.1546 23.0753 23.0753 0 0 0 A0A9Q1C1I6 A0A9Q1C1I6_HOLLE Gamma-glutamylcyclotransferase family protein HOLleu_20370 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytosol [GO:0005829] gamma-glutamylaminecyclotransferase activity [GO:0061929] 1 8.1 1.0077 -6.0779 DSGNGMATFVCCCQ 0 26.3623 26.3623 0 0 0 0 0 0 26.2447 0 0 0 0 0 0 0 0 A0A9Q1C1J6 A0A9Q1C1J6_HOLLE Zinc finger ZZ-type and EF-hand domain-containing protein 1 HOLleu_18272 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion binding [GO:0008270] 2 0.9 1.0191 -5.6217 HCNVCDDFDLCYGCHQT;SNDSSSSDSD 0 0 0 0 0 0 0 0 0 22.8425 0 0 0 0 0 0 0 0 A0A9Q1C1K3 A0A9Q1C1K3_HOLLE MYCBP-associated protein HOLleu_20807 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.2 1.0242 -5.5496 TPQRARSPVDA 0 0 0 0 0 0 0 0 0 0 22.8285 22.8285 0 0 0 0 0 0 A0A9Q1C1K9 A0A9Q1C1K9_HOLLE separase (EC 3.4.22.49) HOLleu_20281 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) meiotic chromosome separation [GO:0051307]; proteolysis [GO:0006508] centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] cysteine-type endopeptidase activity [GO:0004197] 2 0.8 1.0283 -23.442 KGRGKGKK;VKKKSVQAKSKK 0 0 0 0 0 0 0 0 0 0 24.7609 24.7609 0 21.8501 21.8501 0 0 0 A0A9Q1C1M0 A0A9Q1C1M0_HOLLE TBC1 domain family member 5 HOLleu_20302 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) GTPase activator activity [GO:0005096] 1 1.1 1.0038 -23.777 EWIRLFEC 0 0 0 0 0 0 0 0 0 23.5812 0 0 0 0 0 0 0 0 A0A9Q1C1N3 A0A9Q1C1N3_HOLLE PHD finger protein 14 HOLleu_20554 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] metal ion binding [GO:0046872] 2 1.7 1.0122 -12.261 DSDGDEYGEEEEG;SDGDEYGEEEEG 0 0 0 0 0 0 0 0 0 23.5573 0 0 0 0 0 0 0 0 A0A9Q1C1S6 A0A9Q1C1S6_HOLLE Odorant receptor HOLleu_18427 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 6 0.9964 -34.72 AICLMWPLFCSTYRAIIKIY;RPCQACET 0 19.9097 19.9097 0 0 0 0 0 0 19.0329 17.3835 17.3835 0 0 0 0 0 0 A0A9Q1C1T5 A0A9Q1C1T5_HOLLE ATP-dependent RNA helicase dhx29 HOLleu_20570 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] 2 1.8 1.0133 -11.69 ESHKVFSDPSRYLLIALH;WSYEFCYG 20.3978 21.0497 21.0497 0 0 0 0 0 0 21.4991 20.7825 20.7825 19.0299 0 0 16.6081 0 0 A0A9Q1C1T7 A0A9Q1C1T7_HOLLE Tyrosine-protein kinase transmembrane receptor Ror HOLleu_20729 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 4 6.5 1.0135 -11.045 CMGGSCECMEPGYY;DACEDIDECSENS;EDIDECSENSHTCDSITSNC;MGGSCECM 25.0828 25.7086 25.7086 0 0 0 0 0 0 26.2859 25.4261 25.4261 17.878 21.1698 21.1698 0 0 0 A0A9Q1C1V5 A0A9Q1C1V5_HOLLE Mucin-like protein HOLleu_20608 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] membrane [GO:0016020] calcium ion binding [GO:0005509] 2 1.7 1.0051 -8.4152 ECDRHTDTCDSDFAGCTNTDGG;NARNGTCLDYDECDYDLDDCD 23.0069 20.5201 20.5201 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C1W9 A0A9Q1C1W9_HOLLE Uncharacterized protein HOLleu_20500 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] 1 4 1.0193 -23.723 YCEYPEHSG 17.1758 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C1X1 A0A9Q1C1X1_HOLLE Sushi domain-containing protein 2 HOLleu_20695 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] 1 1.4 0.84507 -0.068637 IGGFIREW 0 0 0 0 0 0 0 0 0 0 22.9211 22.9211 0 0 0 0 0 0 A0A9Q1C1X3 A0A9Q1C1X3_HOLLE Shell matrix protein HOLleu_17861 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 11.6 1.0082 -8.1712 NGDDNDDNDQDGDDDDNDDDD;SQDTSDVDEENSDDDEDDDDSDG;VDEENSDDDEDDDDSDGNDDDDD 21.8117 20.8146 20.8146 0 0 0 0 0 0 18.643 20.8692 20.8692 0 15.5909 15.5909 0 0 0 A0A9Q1C1X5 A0A9Q1C1X5_HOLLE WD repeat-containing protein 49 HOLleu_20644 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.2 0.83333 -0.068637 RHNGHQEWTRMVKFAQHLDCFISCC 0 0 0 0 0 0 0 20.2464 20.2464 0 0 0 0 0 0 0 0 0 A0A9Q1C205 A0A9Q1C205_HOLLE Uncharacterized protein HOLleu_17425 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.9 1.0193 -21.924 FYHRKVTGKRICYSC 0 22.4551 22.4551 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C208 A0A9Q1C208_HOLLE Myosin phosphatase Rho-interacting protein HOLleu_17588 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin cytoskeleton [GO:0015629] actin filament binding [GO:0051015] 2 1.3 1.0273 -23.511 ILRQKLKEKEEL;LIKAGTAK 0 24.8213 24.8213 0 0 0 20.4873 0 0 25.4636 25.3765 25.3765 0 0 0 0 0 0 A0A9Q1C225 A0A9Q1C225_HOLLE Transducin beta-like protein 3 HOLleu_17920 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] U3 snoRNA binding [GO:0034511] 1 3.3 1.0197 -23.723 WSDEREEEE 18.5101 18.3913 18.3913 0 0 0 20.0098 19.9548 19.9548 0 0 0 0 17.9527 17.9527 0 0 0 A0A9Q1C229 A0A9Q1C229_HOLLE "Dynein heavy chain 10, axonemal" HOLleu_20743 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cilium movement involved in cell motility [GO:0060294] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] 1 0.2 0.83562 -0.068637 SQDDFDDD 0 0 0 0 0 0 0 0 0 0 20.5115 20.5115 0 0 0 0 0 0 A0A9Q1C251 A0A9Q1C251_HOLLE Asialoglycoprotein receptor 1 HOLleu_17410 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 5.8 0.79412 -0.068637 GANTCARM 25.4506 26.9753 26.9753 0 17.8784 0 23.8833 0 0 0 0 0 0 24.1334 24.1334 0 0 0 A0A9Q1C278 A0A9Q1C278_HOLLE Gustatory receptor HOLleu_18067 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.4 0.99703 -4.7869 DETQDTSSCDDWDQDEDR 21.3871 22.6096 22.6096 0 0 0 0 0 0 0 21.9403 21.9403 18.755 18.4533 18.4533 0 0 0 A0A9Q1C292 A0A9Q1C292_HOLLE Neurogenic locus notch-like protein 1 HOLleu_18727 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 2 0.4 0.99782 -29.973 PCVNGQCVN;SDEDDCQPTNPCQ 0 18.092 18.092 0 0 0 0 0 0 0 19.4824 19.4824 17.9692 25.3954 25.3954 0 0 0 A0A9Q1C2A6 A0A9Q1C2A6_HOLLE RING finger protein unkempt-like HOLleu_17880 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] metal ion binding [GO:0046872] 1 2.4 1.007 -4.125 HGDEWGEISNCEQEDMCQYC 0 0 0 0 0 0 0 0 0 23.2562 22.3152 22.3152 0 0 0 0 0 0 A0A9Q1C2C0 A0A9Q1C2C0_HOLLE Sodium/calcium exchanger 3 HOLleu_18143 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion import across plasma membrane [GO:0098703]; cell communication [GO:0007154] axon [GO:0030424]; postsynapse [GO:0098794]; sarcolemma [GO:0042383] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] 2 1.8 1.0061 -8.3965 MAEFDPWCN;MAEFDPWCNETDVCG 21.5733 22.3782 22.3782 0 0 0 0 0 0 21.1824 21.9139 21.9139 17.3816 18.8879 18.8879 0 0 0 A0A9Q1C2D1 A0A9Q1C2D1_HOLLE Kappa-type opioid receptor HOLleu_18161 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] 1 2.1 1.0042 -23.777 SMNIILLN 0 22.0139 22.0139 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C2D7 A0A9Q1C2D7_HOLLE RUN and TBC1 domain-containing protein 3 HOLleu_17857 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.2 1.0248 -23.675 EEDAFWMMCA 0 0 0 0 0 0 0 0 0 19.2842 0 0 0 17.8072 17.8072 0 0 0 A0A9Q1C2E1 A0A9Q1C2E1_HOLLE Lengsin (Glutamate-ammonia ligase domain-containing protein 1) HOLleu_17505 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutamine biosynthetic process [GO:0006542]; lens morphogenesis in camera-type eye [GO:0002089]; nitrogen utilization [GO:0019740] cytoplasm [GO:0005737]; membrane [GO:0016020] glutamine synthetase activity [GO:0004356] 1 2.8 1.0059 -6.2493 EFSDFTFFPDFST 0 0 0 0 0 0 0 0 0 23.7488 0 0 24.5257 23.7673 23.7673 0 0 0 A0A9Q1C2E2 A0A9Q1C2E2_HOLLE "Cysteine desulfurase 1, chloroplastic" HOLleu_18179 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) tRNA modification [GO:0006400] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; tRNA binding [GO:0000049] 1 0.8 1.0197 -23.723 QYQFYAKKK 0 18.8373 18.8373 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C2E5 A0A9Q1C2E5_HOLLE Uncharacterized protein HOLleu_17949 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.7 0.85333 -0.068637 AMWYYELE 0 21.7874 21.7874 0 0 0 0 0 0 22.3187 20.6805 20.6805 17.8353 0 0 0 0 0 A0A9Q1C2G4 A0A9Q1C2G4_HOLLE Zinc finger CCHC domain-containing protein 24 HOLleu_18214 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.5 1.0008 -23.777 SDDHQGDC 0 0 0 0 0 0 0 0 0 0 20.5279 20.5279 0 0 0 0 0 0 A0A9Q1C2G8 A0A9Q1C2G8_HOLLE C-type lectin domain-containing protein HOLleu_17633 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.4 1.007 -6.2493 NLCETSEMTTEMT 0 25.0235 25.0235 0 0 0 26.6759 26.2757 26.2757 24.0499 23.1758 23.1758 21.5417 21.4306 21.4306 0 0 0 A0A9Q1C2J0 A0A9Q1C2J0_HOLLE Transmembrane channel-like protein 7 HOLleu_17716 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] 2 5.2 0.99746 -30.026 PLIIFLGF;PRKLAAKYLKLGI 0 24.5156 24.5156 0 20.7082 20.7082 0 0 0 21.416 0 0 0 22.3169 22.3169 0 0 0 A0A9Q1C2N3 A0A9Q1C2N3_HOLLE Coiled-coil domain-containing protein 96 HOLleu_18044 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cilium assembly [GO:0060271] axoneme [GO:0005930]; ciliary basal body [GO:0036064] 1 2.3 1.0007 -4.979 ATDAEEAIGE 0 0 0 0 0 0 21.3176 22.0485 22.0485 0 0 0 0 0 0 0 0 0 A0A9Q1C2R0 A0A9Q1C2R0_HOLLE Solute carrier organic anion transporter family member 2B1 HOLleu_17824 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347] 2 3.1 1.0154 -5.9923 ACHAGCSGTTVEM;PGDGGGGGGGG 23.0681 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C2S1 A0A9Q1C2S1_HOLLE Pyridoxal-dependent decarboxylase domain-containing protein 1 HOLleu_18122 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carboxylic acid metabolic process [GO:0019752] intracellular membrane-bounded organelle [GO:0043231] carbon-carbon lyase activity [GO:0016830]; pyridoxal phosphate binding [GO:0030170] 1 1 1.0021 -4.979 FDDSSAYYHM 0 0 0 0 0 0 22.6136 22.4671 22.4671 0 0 0 0 0 0 16.9482 0 18.028 A0A9Q1C2Y7 A0A9Q1C2Y7_HOLLE CUB and sushi domain-containing protein 3 HOLleu_15603 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.0099 -2.6427 PDDSSHDAH 0 21.6677 21.6677 0 0 0 0 0 0 21.4988 0 0 0 0 0 0 0 0 A0A9Q1C307 A0A9Q1C307_HOLLE Mucin-4 HOLleu_15644 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] calcium ion binding [GO:0005509] 1 0.3 1.015 -5.7538 TSLECVNGDCYTFEG 0 0 0 0 0 0 21.2141 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C312 A0A9Q1C312_HOLLE Acyl carrier protein HOLleu_18597 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial respiratory chain complex I [GO:0005747] acyl binding [GO:0000035]; acyl carrier activity [GO:0000036] 1 5.8 1.0126 -2.6427 RPAAAITCL 0 0 0 0 0 0 0 21.7517 21.7517 0 0 0 0 0 0 0 0 0 A0A9Q1C318 A0A9Q1C318_HOLLE Small ribosomal subunit protein uS2 HOLleu_18123 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028] 90S preribosome [GO:0030686]; cytosolic small ribosomal subunit [GO:0022627] structural constituent of ribosome [GO:0003735] 1 2.4 1.0166 -2.1738 GSAPGWGG 0 0 0 0 0 0 0 18.7594 18.7594 0 0 0 0 0 0 0 0 0 A0A9Q1C331 A0A9Q1C331_HOLLE Balbiani ring protein 3 HOLleu_15700 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] chitin binding [GO:0008061] 2 10.1 0.96306 -0.17167 CCSPYNWCG;CDPEGINPCCSPYNWCGHSEAHCDC 0 0 0 0 0 0 0 21.5789 21.5789 0 0 0 0 0 0 0 0 0 A0A9Q1C358 A0A9Q1C358_HOLLE Uncharacterized protein HOLleu_18192 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 3.4 1.0024 -2.7921 KRRVTFDLSKNKVKIVSRYLT;SGSDNHGG 20.8919 0 0 0 0 0 21.0469 21.6884 21.6884 21.3439 0 0 20.2895 20.4133 20.4133 0 0 0 A0A9Q1C379 A0A9Q1C379_HOLLE Brain-specific angiogenesis inhibitor 1-associated protein 2 HOLleu_18227 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838] cytosol [GO:0005829]; nucleoplasm [GO:0005654] 1 1.6 1.0048 -4.979 EECEEMLSMD 0 0 0 0 0 0 0 0 0 21.5863 0 0 0 0 0 0 0 0 A0A9Q1C382 A0A9Q1C382_HOLLE Polycomb protein suz12 HOLleu_17925 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ESC/E(Z) complex [GO:0035098]; RSC-type complex [GO:0016586] chromatin DNA binding [GO:0031490]; metal ion binding [GO:0046872] 1 2.5 0.99632 -4.7869 QEMDEDSEEETDPEWMQE 22.5255 19.7797 19.7797 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C3C1 A0A9Q1C3C1_HOLLE ATP-binding cassette sub-family A member 3 HOLleu_18301 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; lipid transporter activity [GO:0005319] 1 0.5 0.87773 -0.068637 VYPGKGGR 21.2653 23.7988 23.7988 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C3C6 A0A9Q1C3C6_HOLLE Tuberin HOLleu_18229 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of cell cycle [GO:0051726]; regulation of small GTPase mediated signal transduction [GO:0051056] membrane [GO:0016020]; nucleus [GO:0005634]; TSC1-TSC2 complex [GO:0033596] GTPase activator activity [GO:0005096] 1 0.4 1.0201 -0.068637 GMEMDFAG 0 0 0 0 0 0 0 0 0 22.8294 22.099 22.099 0 0 0 0 0 0 A0A9Q1C3E1 A0A9Q1C3E1_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_15953 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell division [GO:0051301]; mitotic DNA damage checkpoint signaling [GO:0044773]; phosphorylation [GO:0016310] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 1 2.6 1.0088 -6.0779 RAPEVLLKCEHQTT 22.2675 24.5216 24.5216 0 0 0 0 0 0 0 0 0 19.3732 20.0352 20.0352 0 0 0 A0A9Q1C3K4 A0A9Q1C3K4_HOLLE Guanylate-binding protein 1 HOLleu_18625 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] 1 1.5 0.98757 -0.44187 IRSVKKKIFAVAK 0 0 0 0 0 0 0 0 0 21.6784 22.6752 22.6752 19.6487 0 0 0 0 0 A0A9Q1C3M6 A0A9Q1C3M6_HOLLE Neurogenic locus Notch protein HOLleu_18429 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 0.6 1.0098 -6.0118 ASNPCENGGMCS 0 0 0 0 0 0 0 0 0 0 0 0 0 24.4169 24.4169 0 0 0 A0A9Q1C3N8 A0A9Q1C3N8_HOLLE Tigger transposable element-derived protein 2 HOLleu_18433 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] DNA binding [GO:0003677] 1 2.7 1.0139 -5.7538 ENSPEEELEKCCICG 21.7523 0 0 0 0 0 0 0 0 21.2721 0 0 0 0 0 0 0 0 A0A9Q1C3Q1 A0A9Q1C3Q1_HOLLE Arf-GAP with dual PH domain-containing protein 1 HOLleu_19057 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] "GTPase activator activity [GO:0005096]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" 1 4.4 1.0074 -5.2234 NLPLLKKFVVEKLKKRT 0 0 0 0 0 0 0 0 0 0 0 0 19.9436 21.1653 21.1653 0 0 0 A0A9Q1C3R5 A0A9Q1C3R5_HOLLE Neurogenic locus notch-like protein 1 HOLleu_19048 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 5 2.2 0.99892 -37.115 CAPGYTGDNCEIEIDEC;GWTGNNCD;NPCQNSGSCTD;SQEIDECFS;YDCECFDGYEG 24.9354 22.0041 22.0041 0 0 0 0 0 0 22.8055 22.3169 22.3169 0 0 0 14.4393 0 0 A0A9Q1C3S5 A0A9Q1C3S5_HOLLE "Dynein heavy chain 3, axonemal" HOLleu_18820 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] 1 0.2 1.0062 -23.777 WIPRVFPR 0 0 0 0 0 0 0 0 0 0 0 0 0 20.181 20.181 0 0 0 A0A9Q1C3T2 A0A9Q1C3T2_HOLLE Uncharacterized protein HOLleu_18428 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 5.2 1.0063 -6.6142 QERHCKACETCW;VMIPICALGASTSL 0 0 0 0 0 0 0 0 0 22.8606 0 0 22.6575 0 0 0 0 0 A0A9Q1C3V0 A0A9Q1C3V0_HOLLE Tyrosine-protein kinase CSK HOLleu_19155 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] membrane [GO:0016020] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] 1 1.7 1.0049 -6.2493 NYNENFTCPVYCN 20.5216 22.3857 22.3857 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C3V5 A0A9Q1C3V5_HOLLE Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q HOLleu_18570 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] glycosyltransferase activity [GO:0016757] 1 2.8 1.0023 -23.777 LGGGDGYS 0 0 0 0 0 0 0 19.2689 19.2689 0 0 0 0 0 0 0 0 0 A0A9Q1C3W0 A0A9Q1C3W0_HOLLE IgGFc-binding protein HOLleu_16304 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509] 5 0.9 1.0037 -26.447 CQTGDNDCNPDTGVCSNTEGS;DECTTDSDDCNQICNNFVGGFFC;DGRTCFDVD;NYTCQCNE;SDDCNQICNN 22.5648 0 0 0 15.5109 15.5109 0 0 0 24.0438 23.4411 23.4411 16.9283 19.8474 19.8474 0 0 0 A0A9Q1C3W2 A0A9Q1C3W2_HOLLE asparaginase (EC 3.5.1.1) HOLleu_18835 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) aspartate family amino acid metabolic process [GO:0009066] cytosol [GO:0005829] asparaginase activity [GO:0004067] 1 3.8 1.0083 -6.0779 KIPMVCDDVYSENE 0 0 0 0 0 0 21.8631 21.6674 21.6674 0 0 0 0 0 0 0 0 0 A0A9Q1C430 A0A9Q1C430_HOLLE TBC1 domain family member 2B HOLleu_18674 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.9 1.0189 -23.723 VTSMEDTDD 0 21.1231 21.1231 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C443 A0A9Q1C443_HOLLE WASH complex subunit 2 HOLleu_18999 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] 2 1.5 1.0106 -10.318 EEEEEESSEEEESDLSESD;GLFGDEDDDEDDLFG 23.8219 24.9244 24.9244 18.1302 0 0 0 0 0 24.3382 23.3944 23.3944 19.4103 19.7231 19.7231 0 0 0 A0A9Q1C445 A0A9Q1C445_HOLLE 60S ribosomal protein L18 HOLleu_18637 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] 1 5.9 1.0219 -2.1738 PRKARKVY 0 0 0 0 0 0 0 0 0 0 21.1433 21.1433 17.4047 0 0 0 0 0 A0A9Q1C463 A0A9Q1C463_HOLLE "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase)" HOLleu_18836 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) asparaginyl-tRNA aminoacylation [GO:0006421] cytoplasm [GO:0005737] asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] 1 2 1.0262 -5.5496 TPAGEIIKEFH 23.5139 0 0 0 0 0 0 20.4876 0 0 0 0 20.6993 0 0 0 0 0 A0A9Q1C484 A0A9Q1C484_HOLLE Integrase catalytic domain-containing protein HOLleu_15792 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] 2 3.8 0.88462 -0.068637 MRKWRPPDAPLDEEWRVYHQIVVPR;YVEFAYQKERHFDRW 19.0997 0 0 17.3183 0 0 20.1782 0 0 21.8431 21.992 21.992 0 0 0 0 0 17.1577 A0A9Q1C4C4 A0A9Q1C4C4_HOLLE Solute carrier family 23 member 1 HOLleu_18944 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) organic substance transport [GO:0071702] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 1 1.4 1.013 -23.777 VPPAIALL 0 0 0 0 0 0 22.1846 0 0 0 23.5546 23.5546 0 0 0 0 0 0 A0A9Q1C4D3 A0A9Q1C4D3_HOLLE Protein disulfide-isomerase (EC 5.3.4.1) HOLleu_19169 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum lumen [GO:0005788] protein disulfide isomerase activity [GO:0003756] 1 4.7 1.0073 -5.3628 YFGLKDDQLPTMRIITLDGEMKK 0 20.4556 20.4556 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C4E2 A0A9Q1C4E2_HOLLE A disintegrin and metalloproteinase with thrombospondin motifs 6 HOLleu_15861 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 0.9 1.0254 -5.5496 GSNFNHDTCEC 0 0 0 0 17.4086 0 0 0 0 24.0807 22.9262 22.9262 0 0 0 0 0 0 A0A9Q1C4H8 A0A9Q1C4H8_HOLLE DNA (cytosine-5)-methyltransferase (EC 2.1.1.37) HOLleu_16745 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270] 1 0.6 1.0021 -4.979 KPVFIAKVIY 0 0 0 0 0 0 0 0 0 0 22.7082 22.7082 0 0 0 0 0 0 A0A9Q1C4I1 A0A9Q1C4I1_HOLLE Copper transport protein HOLleu_15670 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] copper ion transmembrane transporter activity [GO:0005375] 1 12.4 0.99161 -0.31124 TENSMDMSSGMDHMHGTGTPMDMN 0 0 0 0 22.7146 0 0 0 0 25.0172 0 0 0 21.8479 21.8479 0 0 0 A0A9Q1C4J1 A0A9Q1C4J1_HOLLE Uncharacterized protein HOLleu_15689 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.1 0.85433 -0.068637 SSTACCDD 0 0 0 0 0 0 0 0 0 0 0 0 21.7617 21.8779 21.8779 0 0 0 A0A9Q1C4L6 A0A9Q1C4L6_HOLLE Uncharacterized protein HOLleu_18960 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.3 1.0204 -23.723 VRRKFPRNR 0 0 0 18.9856 0 0 20.3327 19.5501 19.5501 0 0 0 0 0 0 0 0 0 A0A9Q1C4N6 A0A9Q1C4N6_HOLLE Centriolar coiled-coil protein of 110 kDa-like HOLleu_18995 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) centriole replication [GO:0007099]; ciliary basal body organization [GO:0032053]; negative regulation of centriole elongation [GO:1903723]; regulation of cytokinesis [GO:0032465] centriole [GO:0005814] 1 0.8 1.0159 -23.777 EPEEVFMS 0 0 0 0 0 0 0 0 0 0 0 0 0 17.6072 17.6072 0 0 0 A0A9Q1C4R0 A0A9Q1C4R0_HOLLE MKL/myocardin-like protein 2 HOLleu_18814 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145] nucleus [GO:0005634] transcription coactivator activity [GO:0003713] 1 1.1 1.0177 -5.7538 QTIIFNPFPVQNPPN 0 24.426 24.426 0 18.3404 18.3404 0 0 0 0 21.0651 21.0651 0 19.7213 19.7213 16.6618 0 17.6164 A0A9Q1C4U3 A0A9Q1C4U3_HOLLE "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" HOLleu_15609 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] 1 1.1 1.0118 -2.6427 TCVEEPCLM 0 0 0 0 0 0 21.5459 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C4V8 A0A9Q1C4V8_HOLLE A disintegrin and metalloproteinase with thrombospondin motifs 9 HOLleu_16180 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222] 2 1.1 1.0022 -28.167 QYDVGEYGECSATCGT;VVNCVNLETGEVVGDGSCEG 0 0 0 0 0 0 17.8176 0 0 20.1087 0 0 0 0 0 0 0 0 A0A9Q1C4W8 A0A9Q1C4W8_HOLLE Uncharacterized protein HOLleu_16973 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1.5 1.0037 -24.888 EECCEDQC;KLPEEECCEDQCVL 0 0 0 0 0 0 16.814 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C4X3 A0A9Q1C4X3_HOLLE Orexin receptor type 2 HOLleu_15667 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; neuron projection [GO:0043005] G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277] 1 4.8 0.99632 -4.7869 YDYYNDDYNGHNWDFCNN 0 0 0 0 0 0 0 0 0 25.4896 0 0 0 0 0 0 0 0 A0A9Q1C4Z4 A0A9Q1C4Z4_HOLLE Uncharacterized protein HOLleu_15919 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 0.6 1.0068 -6.552 HFEDLQDDNREMH;WTSVTPKMLSEA 0 25.4743 25.4743 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C521 A0A9Q1C521_HOLLE Negative elongation factor B HOLleu_15958 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of transcription elongation by RNA polymerase II [GO:0034244] NELF complex [GO:0032021] translation elongation factor activity [GO:0003746] 1 2.5 1.0139 -6.0779 LNTILEDRELYNAT 21.9323 0 0 0 0 0 19.4658 19.5441 19.5441 21.1005 20.9053 20.9053 0 0 0 0 0 0 A0A9Q1C536 A0A9Q1C536_HOLLE Protein HID1 HOLleu_19052 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020] 1 0.9 1.013 -23.777 TRRGKKSA 0 0 0 0 14.6827 0 0 0 0 0 15.6969 15.6969 0 0 0 0 0 0 A0A9Q1C543 A0A9Q1C543_HOLLE NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) HOLleu_17138 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) iron-sulfur cluster assembly [GO:0016226] cytosol [GO:0005829] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958] 1 1.5 1.0109 -2.6427 APSADEPYY 0 0 0 0 0 0 26.1021 26.2072 26.2072 0 0 0 0 0 0 0 0 0 A0A9Q1C553 A0A9Q1C553_HOLLE Laminin subunit beta-1 HOLleu_16431 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] basement membrane [GO:0005604] 5 2.3 0.99716 -57.203 CERCNYNYYDY;EGCTACNCS;FYDFGPEG;GECRECMCDV;YQYFARDC 23.7929 20.4011 20.4011 0 19.7533 0 0 0 0 24.4132 23.6288 23.6288 0 0 0 0 0 0 A0A9Q1C557 A0A9Q1C557_HOLLE Multidrug resistance-associated protein 4 HOLleu_16032 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] 1 0.8 1.0247 -5.5496 EGEEDDEDDIM 0 0 0 22.5872 0 22.2696 0 0 0 0 0 0 23.7792 23.6495 23.6495 0 0 0 A0A9Q1C574 A0A9Q1C574_HOLLE TNF receptor-associated factor 3 HOLleu_15810 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; protein K63-linked ubiquitination [GO:0070534]; tumor necrosis factor-mediated signaling pathway [GO:0033209] tumor necrosis factor receptor superfamily binding [GO:0032813]; ubiquitin protein ligase activity [GO:0061630] 1 4.3 1.0184 -23.027 FYSDCFYTSHYGY 0 0 0 0 0 0 19.4149 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C588 A0A9Q1C588_HOLLE Laminin subunit alpha HOLleu_16172 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; tissue development [GO:0009888] membrane [GO:0016020] 3 2.4 1.0177 -16.894 CLCYGHAEECIGQDESGCNCQ;GTDGQCTC;SDCMACDCNMTGSYGNCTNE 0 21.643 21.643 0 16.3956 0 0 0 0 23.1046 21.1843 21.1843 0 0 0 0 0 0 A0A9Q1C593 A0A9Q1C593_HOLLE Down syndrome cell adhesion molecule-like HOLleu_15717 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axon guidance [GO:0007411]; brain development [GO:0007420] axon [GO:0030424]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] 1 0.6 1.0255 -23.723 SDNGHYSCK 0 0 0 0 0 0 0 0 0 0 0 0 19.5342 0 0 0 0 0 A0A9Q1C5A9 A0A9Q1C5A9_HOLLE Serine hydroxymethyltransferase (EC 2.1.2.1) HOLleu_19184 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to leukemia inhibitory factor [GO:1990830]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; L-serine catabolic process [GO:0006565]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829]; nucleus [GO:0005634] cobalt ion binding [GO:0050897]; glycine hydroxymethyltransferase activity [GO:0004372]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; zinc ion binding [GO:0008270] 1 1.7 1.0176 -23.777 TQYYDELE 18.3392 19.7099 19.7099 0 0 0 0 0 0 18.7002 0 0 16.5687 16.8539 16.8539 0 0 0 A0A9Q1C5B2 A0A9Q1C5B2_HOLLE Polyketide synthase 1 HOLleu_16472 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid biosynthetic process [GO:0006633]; secondary metabolite biosynthetic process [GO:0044550] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]; phosphopantetheine binding [GO:0031177] 1 0.4 1.009 -2.6427 HVLKAWVIV 0 0 0 0 0 0 0 0 0 0 0 0 20.9829 0 0 0 0 0 A0A9Q1C5I4 A0A9Q1C5I4_HOLLE V-type proton ATPase subunit G HOLleu_16289 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) vacuolar proton-transporting V-type ATPase complex [GO:0016471] "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" 1 5.7 1.0029 -4.979 LPVIILAHAT 0 0 0 0 0 0 23.4664 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C5J4 A0A9Q1C5J4_HOLLE Mucin-like protein HOLleu_16308 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] membrane [GO:0016020] calcium ion binding [GO:0005509] 6 2.4 0.99646 -64.488 CACTEAWTGDFCEDDFNACLDD;CAPGYEEVNGTC;DECTTDSDDCNQICNNFVGGFFC;DNDCHQNATCVDT;NYTCQCNE;SDDCNQICNN 20.1509 26.5049 26.5049 0 0 0 18.5124 0 0 26.9224 25.7048 25.7048 24.4467 22.3584 22.3584 0 0 0 A0A9Q1C5K0 A0A9Q1C5K0_HOLLE V-type proton ATPase subunit a HOLleu_16048 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) vacuolar acidification [GO:0007035] "plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" 1 0.9 1.027 -0.068637 YPEDGSSG 18.8192 21.3262 21.3262 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C5K9 A0A9Q1C5K9_HOLLE DNA polymerase epsilon subunit 3 HOLleu_16719 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]; leading strand elongation [GO:0006272] CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622] chromatin DNA binding [GO:0031490]; protein heterodimerization activity [GO:0046982] 1 9.4 0.9963 -4.7869 EEDEGIEEEEEEEVEDDD 0 0 0 0 0 0 0 22.6628 22.6628 0 0 0 0 0 0 0 0 0 A0A9Q1C5M0 A0A9Q1C5M0_HOLLE Sushi domain-containing protein 2 HOLleu_16081 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615]; membrane [GO:0016020] 1 0.9 1.0272 -23.442 VVVVVFVLLIVF 19.144 21.4222 21.4222 0 0 0 20.4753 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C5Q9 A0A9Q1C5Q9_HOLLE Uncharacterized protein HOLleu_16029 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 13 1.0064 -2.7235 VDCTCDGDGMGVTCCNVEPYP 0 22.1296 22.1296 0 0 0 0 0 0 20.9996 20.3994 20.3994 0 0 0 0 0 0 A0A9Q1C5R0 A0A9Q1C5R0_HOLLE Uncharacterized protein HOLleu_13892 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 7.7 1.0007 -28.421 CCGDAFCCNG;CWMWSDCFAGAC 0 0 0 0 17.2708 0 0 0 0 0 24.2859 24.2859 22.1305 0 0 0 0 0 A0A9Q1C5S0 A0A9Q1C5S0_HOLLE Caspase-3 HOLleu_16445 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] cysteine-type endopeptidase activity [GO:0004197] 1 1.5 0.87549 -0.068637 QMMDDEEY 0 0 0 0 0 0 23.9442 23.9193 23.9193 0 0 0 0 0 0 0 0 0 A0A9Q1C5S5 A0A9Q1C5S5_HOLLE Tetratricopeptide repeat protein 28 HOLleu_16520 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0232 -23.631 YFKFAKKKRDR 0 0 0 0 0 0 0 0 0 19.5173 0 0 0 0 0 0 0 0 A0A9Q1C5V0 A0A9Q1C5V0_HOLLE Glomulin HOLleu_16886 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] ubiquitin-protein transferase inhibitor activity [GO:0055105] 1 2.1 1.0007 -4.979 YESGFCTCCK 0 0 0 0 0 0 21.722 21.3437 21.3437 0 0 0 0 0 0 0 0 0 A0A9Q1C5V6 A0A9Q1C5V6_HOLLE snRNA-activating protein complex subunit 4 HOLleu_16838 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006] 1 0.3 0.87259 -0.068637 RPRRKAAP 0 0 0 0 20.9083 20.9083 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C5W3 A0A9Q1C5W3_HOLLE Laminin subunit gamma-1 HOLleu_16516 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] basement membrane [GO:0005604] 4 2.7 0.99892 -38.796 EFGCLACFCYGHS;ERCEDNYYQERDGECVDCGC;NCERCEDNYYQE;YDCEPCPCPG 20.7376 23.2063 23.2063 0 0 0 20.9528 0 0 22.7843 26.9477 26.9477 0 0 0 0 0 0 A0A9Q1C5W4 A0A9Q1C5W4_HOLLE Uncharacterized protein HOLleu_16591 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.9 0.87308 -0.068637 SDDEDDDG 23.3749 23.8788 23.8788 0 16.009 16.009 20.2883 20.2337 20.2337 23.3793 22.8112 22.8112 18.6845 18.8569 18.8569 0 0 0 A0A9Q1C5X4 A0A9Q1C5X4_HOLLE Mucin-like protein HOLleu_16306 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160]; Golgi to vacuole transport [GO:0006896]; protein targeting to vacuole [GO:0006623] endosome [GO:0005768]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] calcium ion binding [GO:0005509] 4 2 1.007 -6.2493 CQTGDNDCNPDTGVCSNTEGS;NYTCQCNE;RSCNGFDFGNTSF;SDDCNQICNN 0 24.1694 24.1694 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C5X5 A0A9Q1C5X5_HOLLE Ig-like domain-containing protein HOLleu_14035 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.7 1.007 -6.2493 HDSSYYACTTTSP 0 22.0641 22.0641 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C5X8 A0A9Q1C5X8_HOLLE Uncharacterized protein HOLleu_16923 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 25 1.0065 -6.2493 SPSLNDDESDYPD 0 0 0 0 0 0 21.1498 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C5Z5 A0A9Q1C5Z5_HOLLE Uncharacterized protein HOLleu_16345 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 12.3 1.0191 -5.6907 AMGCPSPSNDVGHGEEYSETSC 0 0 0 0 0 0 0 0 0 19.7185 0 0 0 0 0 0 0 0 A0A9Q1C5Z6 A0A9Q1C5Z6_HOLLE Integrase catalytic domain-containing protein HOLleu_16202 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] 1 2 1.0111 -5.5027 INMRLRVKLKIIQKRE 0 0 0 0 0 0 0 21.4121 21.4121 0 0 0 0 0 0 0 0 0 A0A9Q1C613 A0A9Q1C613_HOLLE PDZ domain-containing protein HOLleu_16242 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; regulation of cellular localization [GO:0060341] apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; nucleus [GO:0005634] 1 1.1 1.0236 -23.675 DMNDAASCYY 17.3419 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C621 A0A9Q1C621_HOLLE Uncharacterized protein HOLleu_16031 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 17.3 1.0021 -0.31124 PKAMRRRKRGKPGGVRRRNRNRKS 0 0 0 0 0 0 0 0 0 23.2188 21.6973 21.6973 0 0 0 0 0 0 A0A9Q1C630 A0A9Q1C630_HOLLE Protein crumbs HOLleu_16718 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 7 7 1.0037 -26.361 CPNGYEGNLCDTDID;GYEGTLCENETDYCASNPCTNG;IDDCPDNVCENGECVDGVNNY;NCEENIDECNSAPCDNGGTCK;PWGLIGGVIGGVILLILLIL;STCAGNGACTDLWWEFSCDCNS;VYVCQCTARYSGDNCE 23.2162 0 0 0 21.0025 21.0025 0 0 0 24.8163 25.1897 25.1897 21.6485 16.4359 16.4359 0 0 0 A0A9Q1C642 A0A9Q1C642_HOLLE Midasin HOLleu_17064 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ribosomal large subunit export from nucleus [GO:0000055] "nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]" ATP binding [GO:0005524] 3 1.1 1.0107 -13.946 MEPQEANSDEEDDGV;VQGIHHYLFTT;WEHCMNQLC 22.2995 25.4529 25.4529 0 0 0 0 0 0 22.7743 21.7901 21.7901 21.2924 21.2093 21.2093 18.1322 0 0 A0A9Q1C648 A0A9Q1C648_HOLLE CAP-Gly domain-containing protein HOLleu_16496 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule anchoring [GO:0034453] centrosome [GO:0005813] microtubule binding [GO:0008017] 1 0.2 0.87786 -0.068637 QEWVDYDD 16.9651 0 0 16.4475 18.065 18.065 0 0 0 23.9802 0 0 0 0 0 0 0 0 A0A9Q1C681 A0A9Q1C681_HOLLE Cubilin HOLleu_17073 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0108 -23.777 PCPSGCAP 0 0 0 0 0 0 0 0 0 23.0212 0 0 0 0 0 0 0 0 A0A9Q1C689 A0A9Q1C689_HOLLE Collagen alpha-1(XXVII) chain B HOLleu_16570 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581] 1 0.7 0.84127 -0.068637 MGYSGSPG 0 0 0 0 0 0 24.1759 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C695 A0A9Q1C695_HOLLE Reverse transcriptase domain-containing protein HOLleu_17189 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.0123 -2.6427 PLQRIQNLT 20.5727 23.2153 23.2153 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C697 A0A9Q1C697_HOLLE Uncharacterized protein HOLleu_16765 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 27.6 1.0137 -5.5027 LCIETISVPQQTYLPV 0 24.6749 24.6749 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C698 A0A9Q1C698_HOLLE Prokineticin receptor 2 HOLleu_16408 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] neuropeptide Y receptor activity [GO:0004983] 1 2 0.84462 -0.068637 WAPFHGYA 0 0 0 0 0 0 0 0 0 24.0265 0 0 0 0 0 0 0 0 A0A9Q1C6D8 A0A9Q1C6D8_HOLLE Neurogenic locus notch-like protein 1 HOLleu_16903 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; developmental growth [GO:0048589]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; Notch signaling pathway [GO:0007219]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 4 2.6 0.99928 -37.012 DSPGMQHEHSPC;FGETCTQNEDNCNPNPCENGGNC;PEGTEDCMEMENNY;TCFNTEGSFYCICD 0 0 0 0 0 0 0 0 0 24.2218 0 0 20.1191 0 0 0 0 0 A0A9Q1C6E1 A0A9Q1C6E1_HOLLE Protein transport protein sec16 HOLleu_17219 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; Golgi organization [GO:0007030]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein transport [GO:0015031] endoplasmic reticulum exit site [GO:0070971]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139] 1 0.4 1.0042 -23.777 SGGGFSGF 0 0 0 0 0 0 0 17.7415 17.7415 0 0 0 0 0 0 0 0 0 A0A9Q1C6F7 A0A9Q1C6F7_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_14415 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 1 0.6 1.0014 -4.979 PGFRGENCSD 0 0 0 0 0 0 21.5459 21.82 21.82 0 0 0 0 0 0 0 0 0 A0A9Q1C6H1 A0A9Q1C6H1_HOLLE Kielin/chordin-like protein HOLleu_16307 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) blood vessel development [GO:0001568]; regulation of angiogenesis [GO:0045765] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 1 5.1 0.848 -0.068637 PMFVPGVL 21.1894 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C6H6 A0A9Q1C6H6_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_14448 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 1 0.7 1.0049 -2.6427 ECHCSFGDC 0 21.476 21.476 0 0 0 0 0 0 20.3032 19.5359 19.5359 0 0 0 0 0 0 A0A9Q1C6N0 A0A9Q1C6N0_HOLLE Guanine nucleotide-binding protein-like 1 HOLleu_17086 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) GTP binding [GO:0005525]; GTPase activity [GO:0003924] 1 3.1 0.99704 -4.7869 AGEDDQSEFTSSEEDGGA 0 22.7311 22.7311 0 0 0 0 0 0 23.3226 0 0 0 0 0 0 0 0 A0A9Q1C6N2 A0A9Q1C6N2_HOLLE RNA helicase (EC 3.6.4.13) HOLleu_13688 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; gamete generation [GO:0007276] nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270] 1 2.5 1.0088 -2.7235 GGGSGGCTDGFNSGGGDADWN 0 0 0 0 0 0 0 0 0 17.93 21.8546 21.8546 20.1207 20.334 20.334 0 0 0 A0A9Q1C6P0 A0A9Q1C6P0_HOLLE Uncharacterized protein HOLleu_16426 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi apparatus [GO:0005794]; membrane [GO:0016020] 1 1.8 1.0098 -2.6427 SEDEYEDEE 0 0 0 0 0 0 0 20.5212 20.5212 0 0 0 0 0 0 0 0 0 A0A9Q1C6U9 A0A9Q1C6U9_HOLLE Uncharacterized protein HOLleu_14695 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.5 1.0223 -23.631 NEEDDDDDELD 0 0 0 0 0 0 0 0 0 20.7989 0 0 0 0 0 0 0 0 A0A9Q1C6V1 A0A9Q1C6V1_HOLLE U3 small nucleolar RNA-associated protein 6-like HOLleu_16530 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] snoRNA binding [GO:0030515] 1 4.3 1.029 -23.442 GGIKKARKVYKK 0 0 0 0 0 0 0 0 0 28.7415 0 0 0 0 0 0 0 0 A0A9Q1C6X3 A0A9Q1C6X3_HOLLE 5-hydroxytryptamine receptor 1B HOLleu_17000 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]" dendrite [GO:0030425]; plasma membrane [GO:0005886] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378] 1 2.3 0.87446 -0.068637 LLVKDAIT 0 0 0 0 0 0 0 22.9238 22.9238 0 0 0 0 0 0 0 0 0 A0A9Q1C6Y0 A0A9Q1C6Y0_HOLLE Kelch-like protein 20 HOLleu_17305 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.8 1.0219 -23.631 GPRTQPRKPIR 0 0 0 0 0 0 0 0 0 0 20.7248 20.7248 0 0 0 0 0 0 A0A9Q1C727 A0A9Q1C727_HOLLE Copper transport protein HOLleu_16979 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] copper ion transmembrane transporter activity [GO:0005375] 1 10.8 1.0185 -17.224 FLHIIQTAIGYCLMLV 0 21.4127 21.4127 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C739 A0A9Q1C739_HOLLE Neurogenic locus Notch protein HOLleu_17145 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 4 2.2 0.99681 -57.958 ETNECQSSPC;GATCTDGPFEYRCTC;QDGVDMYSCECLP;VNEIGTYSCNCSGTGF 0 0 0 0 0 0 0 0 0 23.3435 23.7694 23.7694 0 0 0 0 0 0 A0A9Q1C750 A0A9Q1C750_HOLLE Chitin-binding type-1 domain-containing protein HOLleu_14070 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chitin binding [GO:0008061] 2 20.7 1.0169 -2.2078 CSPWNWCGITADHCDCADCAD;HCDCADCADYGSSASEYRDDYRC 22.4037 0 0 0 0 0 0 0 0 0 22.6095 22.6095 0 0 0 0 0 0 A0A9Q1C782 A0A9Q1C782_HOLLE Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) HOLleu_17106 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) valyl-tRNA aminoacylation [GO:0006438] cytosol [GO:0005829] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] 1 0.7 0.0625 -0.068637 MGSSYDWD 22.123 23.6687 23.6687 0 16.215 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C7A0 A0A9Q1C7A0_HOLLE Hyalin HOLleu_17266 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 1.1 0.86752 -0.068637 TGDDGFTD 0 0 0 0 0 0 0 0 0 0 21.7689 21.7689 0 0 0 0 0 0 A0A9Q1C7A6 A0A9Q1C7A6_HOLLE Netrin-G1 HOLleu_14188 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] axon [GO:0030424]; receptor complex [GO:0043235] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 1 0.9 1.0117 -23.777 YFRDFFSF 0 0 0 0 0 0 18.2615 16.8825 16.8825 0 0 0 0 0 0 0 0 0 A0A9Q1C7A9 A0A9Q1C7A9_HOLLE Pancreatic triacylglycerol lipase HOLleu_14253 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lipid catabolic process [GO:0016042] extracellular space [GO:0005615] lipase activity [GO:0016298] 1 4.2 1.0137 -5.5027 CPNETSFSEGTCPSCD 0 0 0 0 0 0 0 0 0 0 23.4135 23.4135 0 0 0 0 0 0 A0A9Q1C7B4 A0A9Q1C7B4_HOLLE Uncharacterized protein HOLleu_13805 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.3 1.0121 -23.777 CYCTSDFC 0 24.2429 24.2429 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C7E1 A0A9Q1C7E1_HOLLE Phospholipase A2 (EC 3.1.1.4) HOLleu_15046 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543] 1 11.4 1.0046 -4.125 QGGNESDANERYNEYGCWCG 0 0 0 0 0 0 22.7712 19.5811 19.5811 0 0 0 0 0 0 0 0 0 A0A9Q1C7E2 A0A9Q1C7E2_HOLLE Fibulin-2 HOLleu_17101 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 2 3.5 1.0106 -10.861 CEEGSHGCDS;VCFNMDGSYSCECEEGYTRDS 21.3754 22.0522 22.0522 0 15.7048 15.7048 0 20.9142 20.9142 0 20.6542 20.6542 16.5214 16.7297 16.7297 0 0 0 A0A9Q1C7E8 A0A9Q1C7E8_HOLLE Proteasome adapter and scaffold protein ECM29 HOLleu_13860 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020]; proteasome complex [GO:0000502]; receptor complex [GO:0043235] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 1 0.6 0.96084 -0.17167 FCVCPPGFFGQNCETETNECDSNPC 0 0 0 0 0 0 21.3266 21.4839 21.4839 0 0 0 0 0 0 0 0 0 A0A9Q1C7H1 A0A9Q1C7H1_HOLLE Serine-rich 25 kDa antigen protein HOLleu_14386 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 0.86017 -0.068637 SGCSGSAC 21.9611 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C7H9 A0A9Q1C7H9_HOLLE GPI ethanolamine phosphate transferase 2 HOLleu_13982 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] CP2 mannose-ethanolamine phosphotransferase activity [GO:0051267] 1 1 0.85654 -0.068637 LTTTLLLL 0 0 0 0 0 0 0 23.6845 23.6845 0 0 0 0 0 0 0 0 0 A0A9Q1C7J2 A0A9Q1C7J2_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_14424 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 1 0.6 0 -0.068637 DWEEAVTY 0 0 0 0 0 0 0 0 0 0 0 0 20.7547 0 0 0 0 0 A0A9Q1C7J4 A0A9Q1C7J4_HOLLE Retinol dehydrogenase 8 HOLleu_13671 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytosol [GO:0005829] oxidoreductase activity [GO:0016491] 1 3.5 1.0164 -2.6427 EEASNQCSH 18.6638 19.338 19.338 0 0 0 0 0 0 22.0339 20.4555 20.4555 18.0808 17.8806 17.8806 0 0 0 A0A9Q1C7J9 A0A9Q1C7J9_HOLLE Helicase with zinc finger domain 2 HOLleu_16956 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) miRNA processing [GO:0035196] helicase activity [GO:0004386]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA nuclease activity [GO:0004540] 1 0.2 0.84937 -0.068637 LRVGVHIA 0 0 0 19.6503 0 0 19.7058 21.7109 21.7109 22.2758 22.8089 22.8089 21.1466 19.8383 19.8383 17.9595 0 0 A0A9Q1C7M2 A0A9Q1C7M2_HOLLE Tubulin polyglutamylase TTLL7 HOLleu_13806 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] cilium [GO:0005929] tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] 1 1.1 1.0228 -23.675 GGGPIGMANP 18.7276 0 0 0 0 0 18.2065 18.2755 18.2755 0 0 0 0 0 0 0 0 0 A0A9Q1C7M8 A0A9Q1C7M8_HOLLE Receptor-type tyrosine-protein phosphatase S HOLleu_17016 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.2 1.0266 -23.723 DGDNCTETY 0 0 0 0 0 0 0 0 0 0 0 0 0 19.3898 19.3898 0 0 0 A0A9Q1C7N6 A0A9Q1C7N6_HOLLE VCBS repeat-containing protein HOLleu_14018 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 0 -0.068637 LLFPVTIH 0 0 0 0 0 0 0 0 0 0 20.6341 20.6341 0 0 0 0 0 0 A0A9Q1C7Q2 A0A9Q1C7Q2_HOLLE Protein unc-79-like HOLleu_17080 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.5 0.85 -0.068637 NLRGGSQN 0 0 0 0 0 0 0 0 0 0 22.3972 22.3972 0 0 0 0 0 0 A0A9Q1C7U9 A0A9Q1C7U9_HOLLE Receptor-type tyrosine-protein phosphatase alpha HOLleu_15355 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dephosphorylation [GO:0016311] protein tyrosine phosphatase activity [GO:0004725] 1 4.1 1.0225 -23.675 CMVYTEEDYY 0 0 0 0 0 0 0 0 0 0 18.9491 18.9491 0 0 0 0 0 0 A0A9Q1C7V9 A0A9Q1C7V9_HOLLE Phospholipase A2 (EC 3.1.1.4) HOLleu_17225 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543] 1 6.1 0.84647 -0.068637 QQHDDCYG 0 0 0 0 0 0 0 21.4091 21.4091 0 0 0 0 0 0 0 0 0 A0A9Q1C896 A0A9Q1C896_HOLLE Neurogenic locus Notch protein HOLleu_14174 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 4 1.7 1.0213 -18.747 DPCSSDPCFNNASCVNV;DREPDCSDGSDE;DTDDCVNNNC;NCEEEIDECASDPCLNEGTCND 24.7098 22.428 22.428 0 0 0 17.1998 0 0 18.1055 22.1476 22.1476 21.3052 21.3969 21.3969 0 0 0 A0A9Q1C898 A0A9Q1C898_HOLLE Glycogen debranching enzyme (EC 2.4.1.25) (EC 3.2.1.33) (Glycogen debrancher) HOLleu_14456 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980] cytoplasm [GO:0005737] "4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]" 1 0.6 0.99864 -1.3651 PKLDGVPLI 0 0 0 0 0 0 0 0 0 24.2559 0 0 0 0 0 0 0 0 A0A9Q1C8B1 A0A9Q1C8B1_HOLLE Global transcription activator SNF2L2 HOLleu_14852 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; histone binding [GO:0042393]; hydrolase activity [GO:0016787] 2 0.8 1.006 -23.845 QGYMHGPG;SWGPGGAG 0 0 0 17.0042 0 0 26.4634 0 0 0 0 0 0 0 0 14.8487 0 0 A0A9Q1C8H0 A0A9Q1C8H0_HOLLE Apolipophorin HOLleu_14299 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to estrogen stimulus [GO:0071391]; response to estradiol [GO:0032355] lipid transporter activity [GO:0005319] 1 0.3 1.0277 -5.5496 NHKRLDITVTT 0 0 0 0 0 0 0 0 0 20.1885 20.8784 20.8784 0 0 0 0 0 0 A0A9Q1C8J0 A0A9Q1C8J0_HOLLE Lectin-B HOLleu_14075 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chitin binding [GO:0008061] 2 15.1 1.0061 -9.2583 CSPWNWCGITADHCDCADCAD;GITAAHCDCFFCSDYR 0 0 0 0 0 0 0 0 0 23.4078 22.9205 22.9205 0 0 0 0 0 0 A0A9Q1C8K9 A0A9Q1C8K9_HOLLE Sulfotransferase family protein HOLleu_14621 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 0.85141 -0.068637 LPKMKAKH 0 0 0 0 0 0 0 0 0 0 21.5457 21.5457 0 0 0 0 0 0 A0A9Q1C8N4 A0A9Q1C8N4_HOLLE Uncharacterized protein HOLleu_14384 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.3 1.011 -6.0118 SDDDEEHEESTD 0 0 0 0 0 0 0 22.1584 22.1584 0 0 0 0 0 0 0 0 0 A0A9Q1C8P9 A0A9Q1C8P9_HOLLE Interleukin 17-like protein HOLleu_14450 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] cytokine activity [GO:0005125] 1 4.7 0.84774 -0.068637 PMQVLKLV 0 0 0 0 0 0 23.9068 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C8S8 A0A9Q1C8S8_HOLLE Fukutin HOLleu_14359 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein glycosylation [GO:0006486] 2 3.4 1.014 -2.2424 KKFLNAAK;RIIPAMEM 22.1648 23.8257 23.8257 20.0459 20.756 20.756 21.5602 21.0933 21.0933 23.3092 22.7726 22.7726 20.3359 19.9857 19.9857 18.9122 0 0 A0A9Q1C8U9 A0A9Q1C8U9_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_15257 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen fibril organization [GO:0030199]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] protein-lysine 6-oxidase activity [GO:0004720]; serine-type peptidase activity [GO:0008236] 4 0.5 1.014 -11.012 CDGDDDCGDGSD;ERWTCDGDDDCGDGSDEDTN;HNCGHGED;WGVVCDDE 0 22.4563 22.4563 0 0 0 0 0 0 19.6645 19.7684 19.7684 18.1627 0 0 0 0 0 A0A9Q1C8X9 A0A9Q1C8X9_HOLLE Mitogen-activated protein kinase kinase kinase 1 HOLleu_14601 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270] 2 2.9 1.0045 -25.357 EQNCNCNNG;HTQESSESPSKGGG 25.2794 0 0 0 0 0 22.3884 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C8Z4 A0A9Q1C8Z4_HOLLE Interleukin-12 receptor subunit beta-2 HOLleu_15329 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] 1 2.3 1.0016 -6.2493 AFWCTWQSAGETH 0 0 0 0 0 0 0 21.0633 21.0633 0 0 0 0 0 0 0 0 0 A0A9Q1C8Z9 A0A9Q1C8Z9_HOLLE Angiopoietin-1 receptor HOLleu_15366 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.4 1.0271 -23.631 SGKEATRISTT 0 0 0 0 0 0 19.6306 19.3566 19.3566 20.6792 0 0 0 0 0 0 0 0 A0A9Q1C919 A0A9Q1C919_HOLLE Hyalin HOLleu_12323 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 2 0.9 1.0209 -17.375 CPEEFTGQDCSMSTSNAP;PFCEVMVSPCDSNPC 24.4786 22.8147 22.8147 0 0 0 19.8133 0 0 24.9907 24.809 24.809 0 0 0 0 0 0 A0A9Q1C936 A0A9Q1C936_HOLLE Ig-like domain-containing protein HOLleu_15413 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2 1.0155 -2.6427 PWQCSFDCG 0 0 0 0 0 0 0 0 0 20.7243 0 0 0 0 0 0 0 0 A0A9Q1C947 A0A9Q1C947_HOLLE NXPE family member 3 HOLleu_14778 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.2 1.0053 -5.3628 DLKGKLKWDCSENFFCRKGNASI 0 19.9309 19.9309 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C949 A0A9Q1C949_HOLLE Sodium bicarbonate transporter-like protein 11 HOLleu_14583 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic anion transport [GO:0006820]; monoatomic ion homeostasis [GO:0050801] basolateral plasma membrane [GO:0016323] borate efflux transmembrane transporter activity [GO:0080139]; solute:inorganic anion antiporter activity [GO:0005452] 1 1.7 1.0164 -21.924 YPCNCHKYCNGSASH 0 0 0 0 0 0 19.1476 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C980 A0A9Q1C980_HOLLE SOSS complex subunit C HOLleu_15055 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281] nucleoplasm [GO:0005654]; SOSS complex [GO:0070876] 1 11.3 1.0282 -5.5496 NLILPVIPRLP 23.0794 25.3362 25.3362 22.6167 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C9E8 A0A9Q1C9E8_HOLLE UPF0489 protein C5orf22 HOLleu_11910 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 0.99857 -4.979 ETTCDDEDDL 19.113 20.9572 20.9572 0 0 0 0 0 0 20.1771 19.571 19.571 0 0 0 0 0 0 A0A9Q1C9H0 A0A9Q1C9H0_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_14950 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 1 0.8 1.0122 -5.2234 YGKLCNMQCHCASFTSC 0 0 0 0 0 0 0 17.5758 17.5758 23.8136 0 0 0 0 0 0 0 0 A0A9Q1C9L3 A0A9Q1C9L3_HOLLE Very low-density lipoprotein receptor HOLleu_15316 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509] 2 2.7 1.0154 -5.9481 DSDTDCEDGSD;QCDSDTDCED 20.2504 22.1537 22.1537 0 0 0 0 0 0 20.4334 19.9888 19.9888 0 0 0 0 0 0 A0A9Q1C9L7 A0A9Q1C9L7_HOLLE Receptor-type tyrosine-protein phosphatase mu HOLleu_14995 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dephosphorylation [GO:0016311]; synaptic membrane adhesion [GO:0099560] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 2 1.6 1.0038 -4.1937 SCREECHCESNACDKATGEC;VHVSGSSR 22.2657 0 0 0 0 0 0 0 0 0 0 0 19.7776 22.659 22.659 0 0 0 A0A9Q1C9M5 A0A9Q1C9M5_HOLLE G-protein coupled receptors family 1 profile domain-containing protein HOLleu_15048 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528] 1 1 0.85246 -0.068637 DCPGGDDE 0 24.6303 24.6303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C9N4 A0A9Q1C9N4_HOLLE Angiopoietin-1 receptor HOLleu_15359 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 2.8 1.0112 -13.742 DGVCDSCYNGG;MDCSQECHC;PHCDGVCDSCY 0 0 0 22.4739 0 0 0 0 0 24.189 23.6607 23.6607 0 0 0 0 0 0 A0A9Q1C9R0 A0A9Q1C9R0_HOLLE "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5" HOLleu_15116 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] sialyltransferase activity [GO:0008373] 1 2.3 1.0232 -23.631 WQDELLRNKTT 21.8102 21.4655 21.4655 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C9R1 A0A9Q1C9R1_HOLLE Uncharacterized protein HOLleu_15419 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.6 0.85306 -0.068637 SGCSNSTC 23.6497 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C9S7 A0A9Q1C9S7_HOLLE KN motif and ankyrin repeat domain-containing protein 1 HOLleu_15483 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of actin filament polymerization [GO:0030837] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] 1 0.5 1.0117 -23.777 ERCECCPF 0 18.3644 18.3644 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1C9Y0 A0A9Q1C9Y0_HOLLE LRAT domain-containing protein HOLleu_15194 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 3 5 1.0118 -11.964 CWPCCTSFCRSCCLPCCYDRNYFGC;WPCCTSFCRSCCLPCCYD;WPCCTSFCRSCCLPCCYDRNYFGCC 0 19.0892 19.0892 15.739 0 0 24.3786 25.526 25.526 0 0 0 18.6272 19.2282 19.2282 16.6308 0 17.6303 A0A9Q1CA24 A0A9Q1CA24_HOLLE Angiopoietin-1 receptor HOLleu_15332 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] membrane [GO:0016020] 1 2.9 1.0203 -5.6907 CTGVCDSCYNGGICDENNGRCV 0 0 0 0 0 0 20.3648 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CA26 A0A9Q1CA26_HOLLE Vitellogenin-1 HOLleu_15154 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to estrogen stimulus [GO:0071391]; response to estradiol [GO:0032355] lipid transporter activity [GO:0005319] 6 5 0.99505 -79.589 DSSSGSDSSSSSSSSSSDGSSSS;SNSSHDSS;SSSSSDSSSNRDSSSSDD;SSSSSSSSD;SSSSSSSSSSSSSSD;WGRSCETDQ 0 22.8165 22.8165 0 16.5817 0 21.1002 0 0 19.6714 22.8399 22.8449 18.5366 0 0 0 0 0 A0A9Q1CA29 A0A9Q1CA29_HOLLE 60S ribosomal protein L13 HOLleu_11888 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] 1 3.7 0.84959 -0.068637 PKKAGKPR 0 21.3505 21.3505 20.384 0 0 0 21.8583 21.8583 23.8553 0 0 0 20.0839 20.0839 18.5099 0 0 A0A9Q1CA34 A0A9Q1CA34_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_15357 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 2 0.9 1.0072 -8.1923 GWTGDNCQECD;TGDNCQECD 25.7545 23.9234 23.9234 15.4502 16.843 16.843 0 0 0 0 0 0 0 23.6153 23.6153 0 0 0 A0A9Q1CA57 A0A9Q1CA57_HOLLE Peptidase aspartic putative domain-containing protein HOLleu_15399 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 0.99163 -0.31312 LPKLFTKKRL 0 0 0 19.6602 0 0 21.8608 0 0 0 22.9446 22.9446 0 0 0 0 0 0 A0A9Q1CAA3 A0A9Q1CAA3_HOLLE Heat shock 70 kDa protein IV HOLleu_11768 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] 1 1.2 0.84274 -0.068637 RIPKIQKM 0 0 0 0 0 0 0 0 0 23.3926 0 0 0 0 0 0 0 0 A0A9Q1CAA9 A0A9Q1CAA9_HOLLE Angiopoietin-1 receptor HOLleu_15482 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.8 1.0158 -5.5027 GAGCTQPCRCSSGHCD 0 0 0 0 0 0 0 0 0 21.7395 0 0 0 0 0 0 0 0 A0A9Q1CAB9 A0A9Q1CAB9_HOLLE Hyalin HOLleu_15500 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 3 0.9 0.99781 -29.069 FTGNLCESGPCDSNPCQ;GGTGTACF;NSGACADD 0 0 0 19.166 21.0947 21.0947 0 20.1198 20.1198 25.5476 24.8275 24.8275 23.286 0 0 0 0 0 A0A9Q1CAD0 A0A9Q1CAD0_HOLLE Transcription factor 25 HOLleu_12586 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytoplasm [GO:0005737]; RQC complex [GO:1990112] 1 1.5 1.0007 -4.979 ENEEDQDMEE 0 0 0 0 21.2389 21.2389 0 0 0 0 0 0 23.0174 22.8291 22.8291 0 0 0 A0A9Q1CAE1 A0A9Q1CAE1_HOLLE C2H2-type domain-containing protein HOLleu_11764 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 1 1.4 1.0162 -22.715 MDLSEDEEDMFSCG 0 0 0 0 0 0 0 0 0 18.2565 17.6981 0 0 0 0 0 0 0 A0A9Q1CAK3 A0A9Q1CAK3_HOLLE Protein spire-like 1 HOLleu_11921 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; Golgi vesicle transport [GO:0048193]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; protein transport [GO:0015031] cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] actin binding [GO:0003779] 1 1.2 1.0022 -4.979 ETDSCEEGEE 0 21.9567 21.9567 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CAK4 A0A9Q1CAK4_HOLLE Integrase zinc-binding domain-containing protein HOLleu_12215 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676] 2 2.5 1 -3.2451 DCERDFADF;QLAASRALQEEQRQ 0 0 0 0 0 0 0 0 0 24.7705 0 0 0 0 0 0 0 0 A0A9Q1CAK7 A0A9Q1CAK7_HOLLE Hydrocephalus-inducing protein-like HOLleu_12668 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341] axoneme [GO:0005930] 1 0.5 1.0046 -4.125 VAIVKPALKNKKGVPLLLFT 0 23.6452 23.6452 18.3072 19.7654 19.7654 22.5642 20.5565 20.5565 24.6723 24.2355 24.2355 21.2754 20.9685 20.9685 16.9814 0 18.3305 A0A9Q1CAM9 A0A9Q1CAM9_HOLLE Protein ALP1-like HOLleu_11787 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 2 7.1 1.0213 -21.285 ALEEGDLKTYKRLLR;KALPVGLKVALTLRFLA 0 0 0 0 0 0 0 0 0 0 21.0746 21.0746 0 0 0 0 0 0 A0A9Q1CAS5 A0A9Q1CAS5_HOLLE Protein virilizer-like HOLleu_12837 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] RNA binding [GO:0003723] 1 0.6 1.0228 -23.631 WEPQDGGDWEE 0 0 0 0 0 0 20.115 0 0 0 0 0 0 0 0 0 0 15.6196 A0A9Q1CAS7 A0A9Q1CAS7_HOLLE Calcium-responsive transactivator HOLleu_11885 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.4 1.0151 -6.0779 SSNMQGMAGNYYSH 0 22.3947 22.3947 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CAS9 A0A9Q1CAS9_HOLLE Tonsoku-like protein HOLleu_12063 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297] nuclear replication fork [GO:0043596] 1 0.8 1.0118 -2.6427 HIQDDNMHE 0 0 0 0 0 0 21.5459 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CAU3 A0A9Q1CAU3_HOLLE Cysteine-rich motor neuron 1 protein HOLleu_12392 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] basement membrane [GO:0005604]; extracellular space [GO:0005615] metal ion binding [GO:0046872] 1 2.6 1.0143 -5.8824 YCGGCNAEFFVDDEKVDCEGE 0 0 0 0 0 0 0 0 0 0 0 0 21.6369 17.0968 17.0968 0 0 0 A0A9Q1CAU5 A0A9Q1CAU5_HOLLE CCAAT/enhancer-binding protein gamma HOLleu_12417 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 4 0.86972 -0.068637 GGGKMGRS 0 0 0 0 0 0 0 0 0 0 0 0 0 20.724 20.724 0 0 0 A0A9Q1CAV2 A0A9Q1CAV2_HOLLE Apolipoprotein D HOLleu_12163 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lipid metabolic process [GO:0006629]; response to reactive oxygen species [GO:0000302] cytoplasm [GO:0005737] cholesterol binding [GO:0015485]; pigment binding [GO:0031409] 1 3.7 1.0121 -23.777 DNGEDDHG 0 0 0 0 0 0 19.0787 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CAW6 A0A9Q1CAW6_HOLLE Tenascin-R HOLleu_12108 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020] 2 5.7 1.0273 -23.614 VYGTCSCQKSCDNPTGCVSCNQGQG;YYYDCHIKYTEM 20.0022 19.7813 19.7813 0 0 0 22.4951 24.4087 24.4087 0 0 0 0 0 0 0 0 0 A0A9Q1CAW8 A0A9Q1CAW8_HOLLE Hyalin HOLleu_12430 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 3 0.6 1.0066 -8.3203 GVAMVSMR;INCYQYTCECQGCF;VIVVWVPP 0 20.7708 20.7708 19.9891 17.5382 17.5382 0 0 0 23.1259 20.8731 20.8731 21.5142 0 0 17.798 0 0 A0A9Q1CAY4 A0A9Q1CAY4_HOLLE Uncharacterized protein HOLleu_12490 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 29.2 1.0097 -14.344 IISIVLILTIILRCIRKL;LTIILRCIRKLQKKAKLAKPT 22.5726 0 0 0 0 0 0 0 0 0 0 0 0 19.825 19.825 0 0 0 A0A9Q1CAZ5 A0A9Q1CAZ5_HOLLE Hyalin HOLleu_12507 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 3 1 0.9971 -30.629 DRCQTETDPCDG;SQDNPCNNFPCQNFG;VAAIVIRMRRPKETRTDEVV 22.8704 0 0 19.9186 0 17.7723 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CB17 A0A9Q1CB17_HOLLE C2H2-type domain-containing protein HOLleu_12940 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 0.3 0.87018 -0.068637 PAGSSAKQ 0 0 0 0 0 0 0 0 0 20.8865 20.6724 20.6724 0 0 0 0 0 0 A0A9Q1CB28 A0A9Q1CB28_HOLLE Protein artichoke HOLleu_12963 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.6 0.86713 -0.068637 CPEECSCF 22.6565 24.1156 24.1156 0 0 0 0 0 0 24.0045 23.0856 23.0856 0 0 0 0 0 0 A0A9Q1CB52 A0A9Q1CB52_HOLLE LIM domain-containing protein jub HOLleu_12139 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoskeleton organization [GO:0007010]; negative regulation of hippo signaling [GO:0035331]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; response to hypoxia [GO:0001666] adherens junction [GO:0005912]; nucleus [GO:0005634]; P-body [GO:0000932]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] 1 1.7 0.86411 -0.068637 NCFVCCSC 20.7734 19.8875 19.8875 0 0 0 18.6293 18.2261 18.2261 20.2589 19.4913 19.4913 0 0 0 0 0 0 A0A9Q1CB61 A0A9Q1CB61_HOLLE Uncharacterized protein HOLleu_13014 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.7 0.86111 -0.068637 RMGQTGGG 0 25.3924 25.3924 18.5343 19.7209 19.7209 23.4112 23.1646 23.1646 0 0 0 0 0 0 0 0 0 A0A9Q1CB64 A0A9Q1CB64_HOLLE Organic solute transporter subunit alpha HOLleu_12597 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.3 0.85813 -0.068637 YKASKIHL 0 0 0 0 0 0 0 0 0 0 21.8643 21.8643 0 0 0 0 0 0 A0A9Q1CB95 A0A9Q1CB95_HOLLE Secretagogin HOLleu_12692 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509] cytosol [GO:0005829]; dendrite [GO:0030425]; nucleus [GO:0005634]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509] 1 3.7 1.0232 -23.631 LNIKPQDNFLT 0 0 0 0 0 0 0 0 0 20.381 0 0 0 0 0 0 0 0 A0A9Q1CBB2 A0A9Q1CBB2_HOLLE NFX1-type zinc finger-containing protein 1 HOLleu_13111 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulatory ncRNA-mediated heterochromatin formation [GO:0031048] cytoplasm [GO:0005737]; nuclear RNA-directed RNA polymerase complex [GO:0031380] helicase activity [GO:0004386]; zinc ion binding [GO:0008270] 2 1 0.99963 -28.756 RPKVLLPVRA;RPLLVVCY 0 0 0 0 21.2578 21.2578 24.6194 22.791 22.791 0 17.4205 17.4205 0 16.3895 16.3895 0 0 0 A0A9Q1CBC2 A0A9Q1CBC2_HOLLE Metallophosphoesterase 1 HOLleu_13127 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) GPI anchor biosynthetic process [GO:0006506] membrane [GO:0016020] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] 1 2.6 1.0215 -23.675 TKFILLIGLL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20.3959 0 0 A0A9Q1CBC5 A0A9Q1CBC5_HOLLE Interferon-induced very large GTPase 1 HOLleu_13646 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924] 1 0.8 1.014 -5.7538 NNGDGDGDSSSCSSS 19.7348 21.4843 21.4843 0 16.6479 0 0 0 0 0 21.0949 21.0949 0 0 0 0 0 0 A0A9Q1CBE0 A0A9Q1CBE0_HOLLE L-fucose kinase HOLleu_12467 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) GDP-L-fucose salvage [GO:0042352]; phosphorylation [GO:0016310] ATP binding [GO:0005524]; fucokinase activity [GO:0050201] 1 0.7 0.56 -0.068637 WKALHGLK 0 0 0 17.4111 18.1142 18.1142 19.8963 0 19.6959 21.6965 0 0 0 18.1613 18.1613 0 0 0 A0A9Q1CBE1 A0A9Q1CBE1_HOLLE Cyclic nucleotide-gated cation channel beta-1 HOLleu_12596 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] 1 0.9 1.0211 -23.675 KKKKRGKSLI 0 0 0 0 0 0 0 0 0 0 20.2782 20.2782 0 0 0 0 0 0 A0A9Q1CBE4 A0A9Q1CBE4_HOLLE Cystine/glutamate transporter HOLleu_12306 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] L-amino acid transmembrane transporter activity [GO:0015179] 1 1.8 1.0021 -4.979 PAILFKLVEK 0 0 0 0 0 0 0 22.4157 22.4157 0 0 0 0 0 0 0 0 0 A0A9Q1CBE6 A0A9Q1CBE6_HOLLE Ig-like domain-containing protein HOLleu_09374 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular region [GO:0005576]; membrane [GO:0016020] lipid binding [GO:0008289] 1 1 1.0113 -23.777 LKGAAAAG 0 0 0 0 0 0 0 0 0 20.7275 0 0 0 0 0 0 0 0 A0A9Q1CBE8 A0A9Q1CBE8_HOLLE Hyalin HOLleu_12742 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.4 0.98129 -0.92107 SDVGDPCSSSPCQNGGMC 0 21.7951 21.7951 16.9671 18.1817 18.1817 0 0 0 23.4629 17.8817 17.8817 18.0531 0 0 0 0 0 A0A9Q1CBG1 A0A9Q1CBG1_HOLLE Endoglucanase (EC 3.2.1.4) HOLleu_12502 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellulose catabolic process [GO:0030245] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; polysaccharide binding [GO:0030247]" 1 0.9 1.0127 -2.6427 TTALRKLTT 0 0 0 0 0 0 0 20.9283 20.9283 0 0 0 0 19.444 19.444 0 0 0 A0A9Q1CBI1 A0A9Q1CBI1_HOLLE Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre-mRNA-processing factor 4 homolog) HOLleu_12794 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA cis splicing, via spliceosome [GO:0045292]; phosphorylation [GO:0016310]" ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 2 2.2 1.003 -4.3338 SEGSSSEESSGEEEEEEEDE;SSSEGSSSEESSGEEEEEEEDEDD 19.2602 0 0 0 0 0 23.6445 23.4047 23.4047 0 0 0 0 0 0 0 0 0 A0A9Q1CBI4 A0A9Q1CBI4_HOLLE Solute carrier family 10 member 6 HOLleu_12703 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] symporter activity [GO:0015293] 2 6.9 1.0106 -10.342 PKIIRPQGILIGIA;PLLVATLTIIEGIIAVVIYLLM 0 27.6621 27.6621 24.6178 26.1317 26.1317 0 0 0 0 0 0 24.718 24.9824 24.9824 24.526 21.6486 21.6486 A0A9Q1CBI8 A0A9Q1CBI8_HOLLE SCAN box domain-containing protein HOLleu_12855 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 3.9 1.0246 -5.5496 FYLKNNILIRK;YVEFAYQKERHFDRW 0 0 0 0 0 0 0 0 0 0 0 0 0 21.8483 21.8483 0 0 0 A0A9Q1CBJ0 A0A9Q1CBJ0_HOLLE ABC transmembrane type-1 domain-containing protein HOLleu_12813 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) transmembrane transport [GO:0055085] membrane [GO:0016020] 2 9.1 1.0128 -11.698 LLLLLLLLPLLLLLFLLLL;RLLLPLLLLLLL 0 0 0 0 0 0 0 0 0 0 20.028 20.028 0 0 0 0 0 0 A0A9Q1CBL1 A0A9Q1CBL1_HOLLE Cytoplasmic tRNA 2-thiolation protein 2 HOLleu_12762 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein urmylation [GO:0032447]; tRNA wobble position uridine thiolation [GO:0002143] cytosol [GO:0005829] nucleotidyltransferase activity [GO:0016779]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049] 1 2.1 1 -4.979 SSCCGQGDGS 0 21.7298 21.7298 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CBN0 A0A9Q1CBN0_HOLLE AKT-interacting protein HOLleu_12932 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.3 1.0113 -23.777 PCDSDDDH 18.5116 19.9791 19.9791 0 0 0 0 0 0 0 0 0 16.5892 0 0 0 0 0 A0A9Q1CBP1 A0A9Q1CBP1_HOLLE "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2)" HOLleu_12910 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; pyrimidine ribonucleotide biosynthetic process [GO:0009220] mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886] dihydroorotate dehydrogenase activity [GO:0004152] 1 2.8 1.024 -5.5496 HVAALKRLKAR 26.4996 0 0 0 0 0 0 0 0 27.013 25.1493 25.1493 25.5598 26.2574 26.2574 0 0 0 A0A9Q1CBR9 A0A9Q1CBR9_HOLLE Hyalin HOLleu_12744 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.4 1.0188 -21.924 TYTCTDASGNNEMCS 0 0 0 0 0 0 0 18.4652 18.4652 0 0 0 0 0 0 0 0 0 A0A9Q1CBU9 A0A9Q1CBU9_HOLLE Hyalin HOLleu_12745 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 2 0.4 0.99709 -29.753 ECPSCYTGEFCEDF;YICECPSCYT 0 18.3381 18.3381 0 0 0 16.1823 23.0538 23.0538 17.7273 0 0 0 0 0 0 0 0 A0A9Q1CBV7 A0A9Q1CBV7_HOLLE Protein fantom HOLleu_12760 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) non-motile cilium assembly [GO:1905515]; retinal rod cell development [GO:0046548] photoreceptor connecting cilium [GO:0032391] thromboxane A2 receptor binding [GO:0031870] 2 1.8 1.0064 -24.233 DTMFEEEPIEEEDE;VRDTPSINQRG 0 24.1574 24.1574 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CBW8 A0A9Q1CBW8_HOLLE Solute carrier family 13 member 2 HOLleu_09690 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] citrate transmembrane transporter activity [GO:0015137]; salt transmembrane transporter activity [GO:1901702]; succinate transmembrane transporter activity [GO:0015141] 1 1.3 0.86552 -0.068637 GCSCCQAK 0 0 0 0 0 0 0 0 0 22.2028 0 0 0 0 0 0 0 0 A0A9Q1CBX9 A0A9Q1CBX9_HOLLE Nuclear receptor corepressor 2 HOLleu_09709 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of transcription by RNA polymerase II [GO:0000122] Set3 complex [GO:0034967] DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714] 1 0.5 0.86254 -0.068637 QVKRKKTL 0 0 0 20.6588 0 0 22.2603 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CBY3 A0A9Q1CBY3_HOLLE Uncharacterized protein HOLleu_13082 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) centriole replication [GO:0007099]; centrosome-templated microtubule nucleation [GO:0090222]; mitotic spindle assembly [GO:0090307]; protein localization to centrosome [GO:0071539] centriole [GO:0005814]; cytoplasm [GO:0005737]; pericentriolar material [GO:0000242] protein kinase binding [GO:0019901] 1 0.2 0.85959 -0.068637 WGGVAVGR 22.3189 24.8353 24.8353 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CC05 A0A9Q1CC05_HOLLE Cysteine-rich secretory protein 3 HOLleu_12701 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 1.0241 -23.723 DDDVCECFC 0 0 0 0 0 0 0 0 0 0 0 0 21.9999 0 0 0 0 0 A0A9Q1CC18 A0A9Q1CC18_HOLLE Uncharacterized protein HOLleu_12869 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] calcium ion binding [GO:0005509]; endopeptidase inhibitor activity [GO:0004866] 5 1.5 0.99716 -49.056 CDNCCGGQ;CEDPGMAE;FQCCDNCCG;PCPSATHE;SPSGSYLC 19.9019 21.8416 21.8416 0 16.6705 0 0 23.14 23.14 22.8388 22.7286 22.7286 20.067 22.8873 22.8873 0 0 0 A0A9Q1CC39 A0A9Q1CC39_HOLLE Hyalin HOLleu_12759 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 3 1.3 0.99786 -47.899 ARPKLPPK;KARPKLPPKP;KLPPKPGKR 24.0733 21.294 21.294 21.6197 22.4202 22.4202 20.927 23.9774 23.9774 21.8828 22.4647 22.4647 20.5565 23.3811 23.3811 20.9312 22.201 22.201 A0A9Q1CC40 A0A9Q1CC40_HOLLE Inositol-1-monophosphatase (EC 3.1.3.25) HOLleu_12906 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) inositol metabolic process [GO:0006020]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165] inositol monophosphate 1-phosphatase activity [GO:0008934]; metal ion binding [GO:0046872] 1 3.3 1.0237 -23.723 CQWTDDPTW 0 0 0 0 0 0 0 19.2475 19.2475 0 0 0 0 0 0 0 0 0 A0A9Q1CC83 A0A9Q1CC83_HOLLE Tubulin beta chain HOLleu_13043 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200] 1 2.9 1.0074 -6.2493 EEEEGDNADYEED 0 0 0 22.167 20.2442 16.9465 0 0 0 0 0 0 24.335 25.189 25.189 0 0 0 A0A9Q1CC89 A0A9Q1CC89_HOLLE Copine-3 HOLleu_13278 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to calcium ion [GO:0071277] plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544] 1 2.2 1.0284 -23.442 DMRMLDGDDGIL 0 0 0 0 0 0 18.0359 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CC96 A0A9Q1CC96_HOLLE Large ribosomal subunit protein eL6 (60S ribosomal protein L6) HOLleu_09507 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] 2 10.4 1.0111 -16.6 KLHKRKLRPS;PTQEGRRKLKNHRKPFKL 25.5113 27.1156 27.1156 22.982 0 0 24.486 0 0 0 27.6861 27.6861 0 24.1842 24.1842 0 22.829 22.829 A0A9Q1CCB4 A0A9Q1CCB4_HOLLE Uncharacterized protein HOLleu_13332 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 1.0206 -23.675 RPSLTNAFSS 0 0 0 0 0 0 0 0 0 20.8518 0 0 0 0 0 0 0 0 A0A9Q1CCC9 A0A9Q1CCC9_HOLLE PAXIP1-associated glutamate-rich protein 1A HOLleu_09514 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148] MLL3/4 complex [GO:0044666] nuclear estrogen receptor binding [GO:0030331] 1 2 0.86007 -0.068637 YNYADDLE 20.3351 21.4715 21.4715 0 0 0 0 0 0 18.2218 0 0 0 0 0 0 0 0 A0A9Q1CCD8 A0A9Q1CCD8_HOLLE IgGFc-binding protein HOLleu_09536 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509] 13 1.5 0.99471 -135.02 ACGPACPP;CADEVNSNPVGDCDENCVEGC;CGCLMDDG;CPVDGCIETCGCPA;CYCEDGYEWINDRC;DSCTTPCPASCGDQDAPSNCPIS;EPANCGCYENGIYY;GWIGDDCDMD;NCPVDDCQEMCRCPDGQV;PNCQYNSNECFSQPCQ;RDCYCNDG;SGDGKVCDDVDECEV;STYECGCVAE 25.4877 26.355 26.355 0 15.9418 15.9418 20.14 0 0 26.0278 23.1218 23.1218 21.4453 22.388 22.388 0 0 0 A0A9Q1CCE9 A0A9Q1CCE9_HOLLE RING-type domain-containing protein HOLleu_12965 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homologous chromosome pairing at meiosis [GO:0007129]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131] synaptonemal complex [GO:0000795] metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789] 1 2.4 0.86054 -0.068637 SPGPGGAA 0 0 0 21.0647 20.6013 20.6013 0 0 0 0 20.7245 20.7245 23.1891 0 0 16.6799 0 0 A0A9Q1CCF4 A0A9Q1CCF4_HOLLE GLIPR1-like protein 1 HOLleu_13403 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] 1 2.5 1.0136 -2.6427 TSGDCACEC 0 0 0 0 0 0 0 0 0 22.1451 21.766 21.766 0 0 0 0 0 0 A0A9Q1CCG0 A0A9Q1CCG0_HOLLE Hyalin HOLleu_12982 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.3 1.0064 -6.2493 EGFMGTFCQTPSF 0 0 0 0 0 0 0 0 0 0 23.4514 23.4514 19.2705 19.1795 19.1795 0 0 0 A0A9Q1CCH7 A0A9Q1CCH7_HOLLE Calcium-transporting ATPase (EC 7.2.2.10) HOLleu_09620 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] 1 0.8 0.86441 -0.068637 FMYYDSGP 0 0 0 0 0 0 0 0 0 21.6952 0 0 0 0 0 0 0 0 A0A9Q1CCJ3 A0A9Q1CCJ3_HOLLE SET and MYND domain-containing protein 4 HOLleu_09698 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heart development [GO:0007507] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872] 1 1.6 1.011 -6.0118 QYFFSCDCRACL 0 23.147 23.147 17.9731 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CCJ7 A0A9Q1CCJ7_HOLLE TLC domain-containing protein 2 HOLleu_10090 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035] plasma membrane [GO:0005886] 1 4.1 1.0255 -2.1738 IPPVLVGV 0 16.6111 16.6111 0 0 0 0 0 0 17.558 0 0 0 0 0 0 0 0 A0A9Q1CCK1 A0A9Q1CCK1_HOLLE "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1" HOLleu_13506 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.3 1.0048 -6.2493 VVSKLSSLLENDS 23.4672 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CCK2 A0A9Q1CCK2_HOLLE Uncharacterized protein HOLleu_09718 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; membrane [GO:0016020] 1 3.3 1.0058 -6.2493 GPDSEGKSSDEEE 0 0 0 0 0 0 0 0 0 21.1193 0 0 0 0 0 0 0 0 A0A9Q1CCK5 A0A9Q1CCK5_HOLLE Tesmin/TSO1-like CXC domain-containing protein HOLleu_10106 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.2 1.0276 -23.631 YMGMVDLLRLF 0 0 0 0 0 0 0 0 0 0 0 0 0 18.0825 18.0825 0 0 0 A0A9Q1CCK9 A0A9Q1CCK9_HOLLE O-acyltransferase like protein HOLleu_13201 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]" 1 1.8 1.0247 -23.027 NIPKLLSGNTSDT 0 0 0 18.2215 18.9568 18.9568 0 0 0 0 20.2059 20.2059 0 0 0 17.7975 0 18.3033 A0A9Q1CCL2 A0A9Q1CCL2_HOLLE Protein FAM92A HOLleu_13523 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cilium assembly [GO:0060271] ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869] 3 9.9 1.0172 -17.122 DDDEEYDDDDENDYAYR;EEEDDDDD;LVTLKAKYIVFG 0 0 0 0 0 0 0 0 0 0 0 0 19.4443 0 0 0 0 0 A0A9Q1CCL9 A0A9Q1CCL9_HOLLE Natterin-3 HOLleu_13076 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] 1 1.4 0.86486 -0.068637 GSGAYWDG 0 0 0 0 18.4661 0 0 25.1435 25.1435 0 23.2935 23.2935 0 0 0 0 0 0 A0A9Q1CCN5 A0A9Q1CCN5_HOLLE MTOR-associated protein MEAK7 (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) HOLleu_13297 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) TOR signaling [GO:0031929] lysosome [GO:0005764]; membrane [GO:0016020] 1 1.6 1.0112 -23.777 QLLLTHVL 0 0 0 0 0 0 0 0 0 0 0 0 20.0219 0 0 0 0 0 A0A9Q1CCP2 A0A9Q1CCP2_HOLLE RanBP-type and C3HC4-type zinc finger-containing protein 1 HOLleu_13574 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of metabolic process [GO:0009893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039] ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842] 1 0.6 1.0112 -23.777 DMHDVSEN 0 0 0 0 0 0 0 19.7144 19.7144 0 0 0 0 0 0 0 0 0 A0A9Q1CCP7 A0A9Q1CCP7_HOLLE Nose resistant to fluoxetine protein 6 HOLleu_13587 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]" 1 2.8 0.9985 -4.564 VESVNMCGEYNSYNPCTSG 20.6439 0 0 0 0 0 21.0325 20.6712 20.6712 0 0 0 0 0 0 0 0 0 A0A9Q1CCS4 A0A9Q1CCS4_HOLLE Transcriptional repressor CTCF HOLleu_13366 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 0.9 0.86532 -0.068637 THEKPHKC 0 0 0 0 0 0 0 0 0 22.2151 21.3023 21.3023 0 0 0 0 0 0 A0A9Q1CCU7 A0A9Q1CCU7_HOLLE Orexin receptor type 2 HOLleu_09385 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 2.2 1.013 -23.777 YVKILKVL 0 20.0311 20.0311 0 0 0 19.2137 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CCW9 A0A9Q1CCW9_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_09955 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930] 1 1.2 1.0111 -5.5027 MEDNNNQCVAMTCENS 0 21.3942 21.3942 0 0 0 0 0 0 19.1777 18.8522 18.8522 0 0 0 0 0 0 A0A9Q1CCZ1 A0A9Q1CCZ1_HOLLE "B(0,+)-type amino acid transporter 1" HOLleu_13441 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] L-amino acid transmembrane transporter activity [GO:0015179] 2 2.9 0.99744 -29.276 KNLPLAILIAVPL;NLPLAILIAVPLV 0 21.8162 21.8162 18.5139 19.7665 19.7665 0 20.4936 20.4936 21.6654 23.1544 23.1544 0 19.4646 19.4646 17.4253 0 18.766 A0A9Q1CCZ5 A0A9Q1CCZ5_HOLLE Phosphoinositide phospholipase C (EC 3.1.4.11) HOLleu_13503 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; positive regulation of epithelial cell migration [GO:0010634]; release of sequestered calcium ion into cytosol [GO:0051209] phosphatidylinositol phospholipase C activity [GO:0004435] 1 0.9 1.0104 -6.0118 KLAIALSIHIIA 0 0 0 0 0 0 23.3601 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CD10 A0A9Q1CD10_HOLLE Golgi apparatus protein 1 HOLleu_13291 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi membrane [GO:0000139] fibroblast growth factor binding [GO:0017134] 1 1.2 1.0171 -22.715 YFLVKACQQMIKTT 0 0 0 0 0 0 0 0 0 18.4877 0 0 0 0 0 0 0 0 A0A9Q1CD11 A0A9Q1CD11_HOLLE RING-type E3 ubiquitin transferase (EC 2.3.2.27) HOLleu_13463 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] zinc ion binding [GO:0008270] 1 0.8 0.86913 -0.068637 PDEDEEGG 0 0 0 0 0 0 0 0 0 0 21.012 21.012 17.69 0 0 0 0 0 A0A9Q1CD12 A0A9Q1CD12_HOLLE Uncharacterized protein HOLleu_09523 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1.8 1.0071 -24.175 QDNPEEAVDH;RPLRPRKI 0 0 0 0 0 0 0 0 0 0 24.9237 24.9237 0 0 0 0 0 0 A0A9Q1CD19 A0A9Q1CD19_HOLLE Chromodomain-helicase-DNA-binding protein 8 HOLleu_13308 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393] 2 0.6 1.0004 -28.654 DDSDDVDDDS;KKQKKKAKAK 25.1225 24.1009 24.1009 0 0 0 19.3309 0 0 22.0311 24.1297 24.1297 0 18.0925 18.0925 0 0 0 A0A9Q1CD20 A0A9Q1CD20_HOLLE Adhesion G protein-coupled receptor L3 HOLleu_10000 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 0.5 0.86622 -0.068637 TNSDGYDD 0 0 0 0 0 0 0 0 0 20.9743 0 0 0 0 0 0 0 0 A0A9Q1CD75 A0A9Q1CD75_HOLLE Uncharacterized protein HOLleu_13585 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 7.1 1.011 -6.0118 CYYSTFYISEPG 0 0 0 0 0 0 21.4293 21.3415 21.3415 0 0 0 0 0 0 0 0 0 A0A9Q1CD80 A0A9Q1CD80_HOLLE Uncharacterized protein HOLleu_10487 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.9 0.97159 -0.068637 CTSSSCGV 23.8079 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CDC3 A0A9Q1CDC3_HOLLE Importin subunit alpha-9 HOLleu_09444 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.1 0.96267 -0.17167 PHQRREQQRTTDFEQRKRKRQELLK 0 0 0 0 0 0 0 0 0 0 0 0 22.0648 0 0 0 0 0 A0A9Q1CDD0 A0A9Q1CDD0_HOLLE Ran-specific GTPase-activating protein HOLleu_09384 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of mitotic centrosome separation [GO:0046604] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear pore [GO:0005643] GTPase activator activity [GO:0005096] 1 0.7 0.72414 -0.068637 ASLWPILK 25.9191 25.2611 25.2611 0 0 0 0 18.9911 18.9911 0 24.9004 24.9004 24.5646 24.3536 24.3536 0 0 0 A0A9Q1CDG9 A0A9Q1CDG9_HOLLE Tyrosine-protein kinase Srms HOLleu_09467 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] receptor complex [GO:0043235] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 1 2.3 1.0122 -6.0118 RMNSLEELPDME 0 21.3551 21.3551 0 0 0 0 0 0 18.9995 0 0 0 0 0 0 0 0 A0A9Q1CDH6 A0A9Q1CDH6_HOLLE DNA-directed RNA polymerase III subunit RPC9 HOLleu_09847 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) transcription initiation at RNA polymerase III promoter [GO:0006384] RNA polymerase III complex [GO:0005666] nucleotide binding [GO:0000166] 1 7.6 1.0277 -23.442 DNQEEEDAEDME 0 0 0 0 0 0 0 0 0 0 19.4635 19.4635 0 0 0 0 0 0 A0A9Q1CDJ5 A0A9Q1CDJ5_HOLLE SEC14-like protein 2 HOLleu_09870 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] 1 2.5 1.0035 -4.979 WGGSMVDPDG 0 0 0 0 0 0 0 0 0 0 23.1461 23.1461 0 0 0 0 0 0 A0A9Q1CDJ8 A0A9Q1CDJ8_HOLLE C-type lectin HOLleu_09522 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 4.4 1.018 -23.777 NCCGGEAA 0 0 0 0 0 0 20.2912 20.1711 20.1711 0 0 0 0 0 0 0 0 0 A0A9Q1CDL0 A0A9Q1CDL0_HOLLE Pescadillo homolog HOLleu_09566 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" "nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]" ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] 1 2.8 1.0182 -16.819 QSDLQASGSQDDEEEED 18.7076 0 0 0 0 0 0 0 0 0 0 0 15.8805 0 0 0 0 0 A0A9Q1CDL5 A0A9Q1CDL5_HOLLE Peripheral-type benzodiazepine receptor-associated protein 1 HOLleu_09907 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) neuromuscular synaptic transmission [GO:0007274] 1 0.4 1.0163 -23.777 SHSSWNGG 0 0 0 0 0 0 0 0 0 19.2275 19.0252 19.0252 0 0 0 0 0 0 A0A9Q1CDL7 A0A9Q1CDL7_HOLLE Uncharacterized protein HOLleu_09571 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9 1.0192 -2.6427 KKHPVRTWQ 19.7648 23.558 23.558 0 0 0 19.5755 18.753 18.753 0 21.9177 21.9177 19.8463 19.796 19.796 0 0 0 A0A9Q1CDM8 A0A9Q1CDM8_HOLLE Transmembrane protease serine 6 HOLleu_09396 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) acrosome reaction [GO:0007340]; proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] 1 3.6 0.9963 -4.7869 QDGECEGESTEWEECPDD 0 0 0 0 20.5206 0 0 0 0 0 0 0 23.3327 22.6746 22.6746 0 0 0 A0A9Q1CDP3 A0A9Q1CDP3_HOLLE Uncharacterized protein HOLleu_10516 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5 1.0276 -5.5496 VQLTVLPHLLL 0 0 0 17.855 18.9353 18.9353 0 0 0 22.3596 0 0 0 0 0 16.7483 0 17.643 A0A9Q1CDQ3 A0A9Q1CDQ3_HOLLE Uncharacterized protein HOLleu_10111 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 0.9 1 -47.349 IPKEILPPLI;LIPKEILPPL 21.2052 0 0 0 0 0 22.9 0 0 0 24.44 24.44 0 0 0 0 0 0 A0A9Q1CDW9 A0A9Q1CDW9_HOLLE Neurogenic locus notch-like protein 1 HOLleu_10289 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 3 2.7 0.99855 -34.079 DACASNPCAENGD;FCEEEEDPCAE;NDGTCRNFGTYFQCDC 0 18.8447 18.8447 0 0 0 23.1624 21.4665 21.4665 22.2265 0 0 0 0 0 0 0 0 A0A9Q1CE01 A0A9Q1CE01_HOLLE Matrix metalloproteinase-24 HOLleu_09810 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] 1 1.5 1.0091 -23.777 PGGGLGGD 0 18.6442 18.6442 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CE10 A0A9Q1CE10_HOLLE Ig-like domain-containing protein HOLleu_09831 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.8 1.0122 -6.0779 KSHFLESIVIMDTT 22.02 24.819 24.819 0 0 0 0 0 0 21.3761 21.0774 21.0774 18.8551 0 0 0 0 0 A0A9Q1CE24 A0A9Q1CE24_HOLLE FACT complex subunit SSRP1 HOLleu_09691 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of chromatin organization [GO:1902275] FACT complex [GO:0035101] DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491] 1 1.3 1.0249 -23.675 KEDDDEEMEE 0 0 0 0 0 0 0 0 0 0 0 0 16.6372 0 0 0 0 0 A0A9Q1CE27 A0A9Q1CE27_HOLLE Peroxidasin-like HOLleu_10781 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) response to oxidative stress [GO:0006979] heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] 1 1.6 1.0128 -6.0118 NESDPMCGFQKC 0 0 0 0 0 0 0 0 0 0 22.1282 22.1282 0 0 0 0 0 0 A0A9Q1CE43 A0A9Q1CE43_HOLLE Zonadhesin HOLleu_09729 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 1 0.5 1.0236 -23.675 MNFEDSRTYC 21.4459 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CE52 A0A9Q1CE52_HOLLE Cyclic nucleotide-gated olfactory channel HOLleu_09988 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] protein-containing complex binding [GO:0044877]; voltage-gated potassium channel activity [GO:0005249] 2 1.9 1.0118 -11.799 RILSLLHILAL;RILSLLHILALLN 0 0 0 0 0 0 26.1978 23.023 23.023 27.8094 0 0 0 22.1536 22.1536 0 0 0 A0A9Q1CE63 A0A9Q1CE63_HOLLE Low-density lipoprotein receptor-related protein 4 HOLleu_09967 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070] membrane [GO:0016020] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] 1 1.2 1.0163 -23.777 CGCCKCEC 0 0 0 0 0 0 0 0 0 0 23.7383 23.7383 0 0 0 0 0 0 A0A9Q1CE77 A0A9Q1CE77_HOLLE RNA helicase (EC 3.6.4.13) HOLleu_09985 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723] 1 1.7 1.007 -4.125 KLTKKQRKNLQRIVNQKIKK 22.7582 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CE80 A0A9Q1CE80_HOLLE Hyalin HOLleu_09971 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.1 1.0134 -6.0118 QVYQQVFWEEPY 0 0 0 0 0 0 21.0465 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CED1 A0A9Q1CED1_HOLLE Neuronal acetylcholine receptor subunit alpha-6 HOLleu_09899 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) response to nicotine [GO:0035094] neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] 1 1.7 1.0189 -23.723 LHFRTIMSH 17.916 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CEE6 A0A9Q1CEE6_HOLLE Uncharacterized protein HOLleu_11262 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.8 1.0184 -2.6427 FMKKWIETT 0 0 0 0 0 0 0 0 0 0 0 0 20.8488 0 0 0 0 0 A0A9Q1CEE9 A0A9Q1CEE9_HOLLE Unconventional myosin-XVIIIa HOLleu_10749 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actomyosin structure organization [GO:0031032] cytoplasm [GO:0005737]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] 1 0.4 1.0193 -2.6427 SMRMKKRKA 19.2603 21.0991 21.0991 0 0 0 0 18.6955 18.6955 21.2017 20.4755 20.4755 18.4754 0 0 0 0 0 A0A9Q1CEF8 A0A9Q1CEF8_HOLLE ATP-dependent DNA helicase (EC 3.6.4.12) HOLleu_10151 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] 3 1 0.99817 -29.062 IKLKKKMIF;NERCCTNMD;YDTHQMHF 23.3867 24.7313 24.7313 0 0 0 0 21.3496 21.3496 16.8023 26.3067 26.3067 22.0348 0 0 0 0 0 A0A9Q1CEL2 A0A9Q1CEL2_HOLLE Latent-transforming growth factor beta-binding protein 4 HOLleu_10255 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 2 5 1.0041 -4.9858 FTLHVIDNDYD;SHASCNNYGGGFSCSCNT 0 0 0 0 0 0 26.5865 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CEL8 A0A9Q1CEL8_HOLLE Eukaryotic translation initiation factor 4E transporter HOLleu_11215 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of translation [GO:0017148] cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634] mRNA binding [GO:0003729]; translation initiation factor activity [GO:0003743] 2 1.3 1.013 -2.2424 DGHPGPPV;NQVRRRVI 0 22.5531 22.5531 0 0 0 21.9211 0 0 0 22.5134 22.5134 0 0 0 0 0 0 A0A9Q1CEP0 A0A9Q1CEP0_HOLLE Fibropellin-1 HOLleu_10292 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; response to stimulus [GO:0050896] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 2 6.3 1.0056 -8.4152 DPCANDGFCFSSDDGNMFLCL;EEHSPFFCMCADGYDGMTCQTA 0 0 0 0 0 0 0 0 0 27.4118 0 0 19.2588 0 0 0 0 0 A0A9Q1CEP6 A0A9Q1CEP6_HOLLE DNA excision repair protein ERCC-6-like HOLleu_11279 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; reciprocal meiotic recombination [GO:0007131]; transcription-coupled nucleotide-excision repair [GO:0006283] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] 1 0.8 1.0049 -6.2493 ENESDTSWEGDEE 21.5959 0 0 0 0 0 20.0743 15.873 0 0 20.6718 20.6718 18.7628 18.7679 18.7679 0 0 0 A0A9Q1CEQ5 A0A9Q1CEQ5_HOLLE B-cell CLL/lymphoma 7 protein family member B-B HOLleu_10753 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.5 0.87361 -0.068637 VRKWEKKW 18.5385 0 0 0 17.9278 17.9278 20.4164 20.508 20.508 21.7151 0 0 0 18.3075 18.3075 0 0 0 A0A9Q1CEQ8 A0A9Q1CEQ8_HOLLE Golgin subfamily A member 3 HOLleu_10356 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] 1 0.4 1.0134 -23.777 TSEGYMQN 0 0 0 0 0 0 0 0 0 17.9387 0 0 0 0 0 0 0 0 A0A9Q1CER1 A0A9Q1CER1_HOLLE C2H2-type domain-containing protein HOLleu_10326 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 2.6 1.0162 -6.0779 QFCEMSFCQESDFI 0 25.6175 25.6175 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CER5 A0A9Q1CER5_HOLLE Uncharacterized protein HOLleu_11324 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.7 0.99158 -0.31124 EECEASLEDEDDHLDEEEGDGEDK 0 0 0 0 0 0 24.5705 22.5387 22.5387 0 0 0 0 0 0 0 0 0 A0A9Q1CEU6 A0A9Q1CEU6_HOLLE Uncharacterized protein HOLleu_11381 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8.5 1.0142 -23.777 VQYTMNLM 0 19.1845 19.1845 0 0 0 0 0 0 19.9093 0 0 0 0 0 0 0 0 A0A9Q1CEX2 A0A9Q1CEX2_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_10890 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actomyosin structure organization [GO:0031032]; mitotic cytokinesis [GO:0000281]; phosphorylation [GO:0016310] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] 1 0.7 1.006 -6.2493 SWDKKWVTLDGPQ 20.5016 23.9203 23.9203 0 17.6436 17.6436 18.7347 0 19.7347 20.4343 20.3969 20.3969 18.4851 18.8647 18.8647 15.8663 0 0 A0A9Q1CF70 A0A9Q1CF70_HOLLE vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) HOLleu_10790 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) vitamin K metabolic process [GO:0042373] endoplasmic reticulum membrane [GO:0005789] quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057] 1 8.8 1.015 -5.7538 DYTAMCDIGDRISCS 19.0646 20.0838 20.0838 0 0 0 0 0 0 21.3792 20.9062 20.9062 0 0 0 0 0 0 A0A9Q1CF72 A0A9Q1CF72_HOLLE Rab5 GDP/GTP exchange factor HOLleu_11639 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; endocytic vesicle [GO:0030139] DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] 1 1.8 1.0176 -2.6427 KPLIKKRYS 0 0 0 0 0 0 20.7602 0 0 21.828 21.5303 21.5303 0 0 0 0 0 0 A0A9Q1CF86 A0A9Q1CF86_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_11672 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1.3 1.0134 -6.0118 LNFVIFILIIRK 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25.879 25.879 A0A9Q1CFA3 A0A9Q1CFA3_HOLLE Protein strawberry notch-like 1 HOLleu_11180 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA-templated transcription [GO:0006355]; regulation of response to stimulus [GO:0048583] nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone binding [GO:0042393] 2 1.4 1.0037 -26.711 DEDVMSDSSDDSSEF;VMSDSSDDSSEFSDINTE 0 23.481 23.481 0 0 0 0 0 0 23.6413 0 0 0 0 0 0 0 0 A0A9Q1CFD6 A0A9Q1CFD6_HOLLE "Protein MTO1 homolog, mitochondrial" HOLleu_11570 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial tRNA wobble uridine modification [GO:0070899]; tRNA methylation [GO:0030488] cytosol [GO:0005829]; mitochondrion [GO:0005739] flavin adenine dinucleotide binding [GO:0050660] 1 2.2 1.0203 -21.924 MSCNPSFGGIGKGHL 19.4992 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CFE8 A0A9Q1CFE8_HOLLE [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354) HOLleu_10620 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] Set1C/COMPASS complex [GO:0048188] histone H3K4 methyltransferase activity [GO:0042800]; RNA binding [GO:0003723] 3 1.5 0.99855 -33.128 EEEDEEEEDEDEDVEDME;EEEEEDEEEEDEDEDVEDM;TMAGMSGM 21.8925 22.2625 22.2625 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CFH6 A0A9Q1CFH6_HOLLE Uncharacterized protein HOLleu_07132 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 0.99925 -4.564 PGSDSEESTSAEPMSSSEE 0 0 0 0 0 0 0 0 0 23.2069 0 0 0 0 0 0 0 0 A0A9Q1CFI0 A0A9Q1CFI0_HOLLE Oxysterol-binding protein HOLleu_10925 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endocytosis [GO:0006897]; exocytosis [GO:0006887]; maintenance of cell polarity [GO:0030011]; piecemeal microautophagy of the nucleus [GO:0034727] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] sterol binding [GO:0032934]; sterol transporter activity [GO:0015248] 1 1.8 1.0169 -6.0779 SEEDEENEFFDAVD 0 0 0 0 0 0 0 0 0 21.6424 0 0 0 0 0 0 0 0 A0A9Q1CFI2 A0A9Q1CFI2_HOLLE Latent-transforming growth factor beta-binding protein 4 HOLleu_10894 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 2 3.7 1.0045 -25.56 FQGNGYQCTDIDECSENTDNCS;WRFSFYKIEVTRY 0 17.8368 17.8368 0 0 0 0 0 0 26.1441 0 0 0 0 0 0 0 0 A0A9Q1CFJ1 A0A9Q1CFJ1_HOLLE G patch domain-containing protein 3 HOLleu_11340 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of DNA-templated transcription [GO:0045893] nucleic acid binding [GO:0003676] 1 3.3 1.0108 -5.2234 ERNVQSESDDDDDTCEE 21.2924 23.1657 23.1657 0 15.8893 15.8893 26.1949 0 0 0 22.3776 22.3776 0 19.1447 19.1447 16.1296 0 0 A0A9Q1CFJ3 A0A9Q1CFJ3_HOLLE Neuronal acetylcholine receptor subunit alpha-7 HOLleu_07240 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; neuron projection [GO:0043005]; synapse [GO:0045202] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] 1 3 1.0116 -6.0118 LPKLLRLVLFMK 0 0 0 22.6904 22.5391 22.5391 0 0 0 25.5721 0 0 0 0 0 20.8723 22.877 22.877 A0A9Q1CFK6 A0A9Q1CFK6_HOLLE Baculoviral IAP repeat-containing protein 6 HOLleu_07194 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) apoptotic process [GO:0006915]; regulation of cytokinesis [GO:0032465] ubiquitin-protein transferase activity [GO:0004842] 1 0.2 1.0144 -2.6427 DEYDWDDEE 0 0 0 0 0 0 0 0 0 24.7932 0 0 0 0 0 0 0 0 A0A9Q1CFM2 A0A9Q1CFM2_HOLLE Solute carrier organic anion transporter family member HOLleu_07200 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347] 1 1.2 0.87778 -0.068637 CNAGCGCE 23.3105 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CFP6 A0A9Q1CFP6_HOLLE CUE domain-containing protein 1 HOLleu_11072 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ubiquitin binding [GO:0043130] 1 1.9 0.87454 -0.068637 LKPNNETT 0 0 0 0 0 0 21.2118 0 0 0 0 0 0 20.2097 20.2097 0 0 0 A0A9Q1CFQ9 A0A9Q1CFQ9_HOLLE ABC transporter B family member 1 HOLleu_11486 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] ABC-type oligopeptide transporter activity [GO:0015421]; ATP binding [GO:0005524] 1 2.5 1.028 -23.442 SFCAMFSGDSYQ 0 24.2009 24.2009 0 0 0 0 19.866 19.866 0 0 0 0 0 0 0 0 0 A0A9Q1CFS5 A0A9Q1CFS5_HOLLE Pecanex-like protein HOLleu_07164 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endoplasmic reticulum organization [GO:0007029] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] 1 1.2 0.87132 -0.068637 RNVTIPESCFSVFLAVLVSFLGYFI 0 22.97 22.97 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CFT7 A0A9Q1CFT7_HOLLE Protein dispatched-like 1 HOLleu_11246 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) smoothened signaling pathway [GO:0007224] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 4 3.3 0.9971 -31.776 LLSKFRKK;MNFCFMDD;PKILFQKILPKLIF;PKILFQKILPKLIFSLR 0 0 0 20.2043 21.5781 21.5781 20.6737 0 0 0 15.6818 15.6818 0 0 0 19.9505 0 20.4661 A0A9Q1CFT8 A0A9Q1CFT8_HOLLE Low density lipoprotein receptor adapter protein 1 HOLleu_11538 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of cell population proliferation [GO:0042127]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377] cytoplasm [GO:0005737] 1 3.3 1.0131 -5.5027 LQRKRKLRQERKLLRK 0 0 0 19.5951 20.3976 20.3976 0 21.7767 21.7767 0 0 0 0 0 0 18.447 0 19.2773 A0A9Q1CFV9 A0A9Q1CFV9_HOLLE Uncharacterized protein HOLleu_07244 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic ion transport [GO:0006811] membrane [GO:0016020] 1 3.6 0.86496 -0.068637 LLLMKRRE 0 0 0 0 0 0 0 0 0 22.8977 0 0 0 0 0 0 0 0 A0A9Q1CFX6 A0A9Q1CFX6_HOLLE Autophagy-related protein 2 HOLleu_07408 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) autophagosome assembly [GO:0000045]; lipid transport [GO:0006869]; piecemeal microautophagy of the nucleus [GO:0034727]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phagophore assembly site membrane [GO:0034045] phosphatidylinositol-3-phosphate binding [GO:0032266] 1 0.4 0.86182 -0.068637 LGGVGPMH 22.0559 23.751 23.751 0 20.976 20.976 21.3747 19.7326 19.7326 23.2876 23.0235 23.0235 19.8171 19.9931 19.9931 0 0 0 A0A9Q1CFY4 A0A9Q1CFY4_HOLLE Fucosyltransferase (EC 2.4.1.-) HOLleu_11338 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fucosylation [GO:0036065]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] alpha-(1->3)-fucosyltransferase activity [GO:0046920] 1 1.9 1.015 -23.777 YDAHWWGS 0 0 0 0 0 0 0 0 0 17.8763 16.838 16.838 0 0 0 0 0 0 A0A9Q1CFZ6 A0A9Q1CFZ6_HOLLE Ryncolin-1 HOLleu_11031 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.7 1.0045 -26.31 DCTQNCTCVGNQLSCHGNYECS;RYCNYFET 17.7919 0 0 0 0 0 0 24.0951 24.0951 18.4432 0 0 0 0 0 0 0 0 A0A9Q1CG05 A0A9Q1CG05_HOLLE Fucosyltransferase (EC 2.4.1.-) HOLleu_11318 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fucosylation [GO:0036065]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] alpha-(1->3)-fucosyltransferase activity [GO:0046920] 1 3.5 1.0121 -16.819 NWIRNYEHPLDHKRRNK 0 22.7776 22.7776 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CG07 A0A9Q1CG07_HOLLE Carboxypeptidase A4 HOLleu_11707 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] 1 2.2 1 -4.979 VGTDMNRNFD 0 0 0 0 0 0 0 21.799 21.799 0 0 0 0 0 0 0 0 0 A0A9Q1CG15 A0A9Q1CG15_HOLLE Merlin HOLleu_11071 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of cell population proliferation [GO:0008285]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of organelle assembly [GO:1902115] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; plasma membrane [GO:0005886] actin binding [GO:0003779]; integrin binding [GO:0005178] 1 2.4 1.0152 -22.715 LRRKPRNFTVRVTT 0 0 0 0 0 0 0 0 0 0 0 0 19.2376 0 0 0 0 0 A0A9Q1CG26 A0A9Q1CG26_HOLLE Uncharacterized protein HOLleu_07478 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 29.4 0.95596 -0.17167 IIRSGVKNVIHLGKQILMLKSLKNK 0 0 0 0 0 0 0 0 0 0 22.9841 22.9841 0 0 0 0 0 0 A0A9Q1CG33 A0A9Q1CG33_HOLLE Laccase-4 HOLleu_11712 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322] 1 1.7 1.015 -23.777 GTPAMDGP 0 0 0 0 0 0 18.4545 18.4993 18.4993 0 16.0727 16.0727 0 0 0 0 0 0 A0A9Q1CG47 A0A9Q1CG47_HOLLE Heterogeneous nuclear ribonucleoprotein A2-like 2 HOLleu_07526 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013] mRNA 3'-UTR binding [GO:0003730] 3 5.5 0.9989 -28.947 GFGGGHGGG;GGYGSGGSSGGSGGGYS;YGGGYGGG 0 21.2067 21.2067 0 0 0 0 0 0 0 0 0 0 17.8083 17.8083 0 0 0 A0A9Q1CG49 A0A9Q1CG49_HOLLE Regulator of G-protein signaling 7 HOLleu_07539 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] 1 2.2 1.0236 -5.5496 DHDHDHHADGN 22.0418 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CG67 A0A9Q1CG67_HOLLE Tumor necrosis factor receptor superfamily member 6 HOLleu_07472 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 10.5 1.0264 -23.442 QRMECQSIVSNN 20.5882 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CGD9 A0A9Q1CGD9_HOLLE Synaptic vesicle 2-related protein HOLleu_11333 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane region [GO:0098590] transmembrane transporter activity [GO:0022857] 1 3.7 0.86594 -0.068637 VDTCSDDC 0 23.579 23.579 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CGG9 A0A9Q1CGG9_HOLLE Sodium-coupled monocarboxylate transporter 2 HOLleu_07732 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sodium ion transport [GO:0006814] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] symporter activity [GO:0015293] 1 1.3 1.0159 -23.777 ILIHMGIV 0 18.1524 18.1524 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CGH1 A0A9Q1CGH1_HOLLE Myb-binding protein 1A HOLleu_11572 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; nucleolus [GO:0005730] rDNA binding [GO:0000182]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] 2 2.8 1.0041 -25.75 AMSSQDGDSDEDDEEGDEEEM;GEGEESESDMSDE 21.6922 18.0635 18.0635 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CGH7 A0A9Q1CGH7_HOLLE Adhesion G protein-coupled receptor L3 HOLleu_11664 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 0.9 0.86282 -0.068637 DCMDGFDC 0 0 0 0 0 0 0 0 0 0 0 0 21.2602 20.4312 20.4312 0 0 0 A0A9Q1CGH8 A0A9Q1CGH8_HOLLE Fibrillin-1 HOLleu_11417 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 4 12.8 1.0112 -13.548 DNGNGGCDD;PGYEDNGNGGCDD;SGYEDNGNGGCDDINECSTNTDG;SGYQGDGTNSGTGCSDIDECSTNTD 0 0 0 0 0 0 0 0 0 0 25.2859 25.2859 25.0585 24.8566 24.8566 0 0 0 A0A9Q1CGJ3 A0A9Q1CGJ3_HOLLE Protein stum HOLleu_07337 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proprioception [GO:0019230]; sensory perception of mechanical stimulus [GO:0050954]; taxis [GO:0042330] membrane [GO:0016020]; sensory dendrite [GO:0071683] 1 2.6 1.0163 -23.777 SMMCCGEP 0 0 0 0 0 0 0 0 0 0 17.8553 17.8553 0 0 0 0 0 0 A0A9Q1CGJ4 A0A9Q1CGJ4_HOLLE Carboxypeptidase A1 HOLleu_11706 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] 2 2 1.0057 -23.845 SYWGGDGA;YWGGDGAS 0 0 0 0 0 0 0 0 0 23.3844 0 0 22.5985 0 0 0 0 0 A0A9Q1CGK4 A0A9Q1CGK4_HOLLE Mitogen-activated protein kinase-binding protein 1 HOLleu_07077 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; phosphorylation [GO:0016310]; positive regulation of JNK cascade [GO:0046330] cytoplasm [GO:0005737] kinase activity [GO:0016301] 1 1.2 1.0116 -10.943 NLWTQQSYMLSQDEDEDDDD 0 0 0 0 0 0 20.6087 20.4311 20.4311 0 0 0 0 0 0 0 0 0 A0A9Q1CGM0 A0A9Q1CGM0_HOLLE Univin HOLleu_07864 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] 1 2.7 1.0248 -5.5496 YQAYYCAGECP 0 25.3621 25.3621 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CGM9 A0A9Q1CGM9_HOLLE Ryanodine receptor 2 HOLleu_07872 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; striated muscle contraction [GO:0006941] calcium channel complex [GO:0034704]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] ryanodine-sensitive calcium-release channel activity [GO:0005219] 1 0.3 1.0227 -23.631 HLWDLTDNKVF 0 0 0 0 0 0 0 17.935 17.935 0 0 0 0 0 0 0 0 0 A0A9Q1CGR8 A0A9Q1CGR8_HOLLE Spastin (EC 5.6.1.1) HOLleu_07951 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule severing [GO:0051013]; positive regulation of microtubule depolymerization [GO:0031117]; protein hexamerization [GO:0034214] centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] 1 1.4 1.0152 -2.6427 LFTGLRAPA 0 0 0 0 0 0 0 0 0 22.5284 0 0 0 0 0 0 0 0 A0A9Q1CGT5 A0A9Q1CGT5_HOLLE Nucleic acid dioxygenase ALKBH1 HOLleu_07972 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281]; oxidative RNA demethylation [GO:0035513]; oxidative single-stranded DNA demethylation [GO:0035552] cytoplasm [GO:0005737]; nucleus [GO:0005634] broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; oxidative RNA demethylase activity [GO:0035515] 1 1.7 1.0137 -2.6427 TDERCEFDH 0 23.2133 23.2133 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CGU1 A0A9Q1CGU1_HOLLE Uncharacterized protein HOLleu_07180 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.2 0.86738 -0.068637 CMCEEDLC 0 0 0 0 0 0 0 22.1285 22.1285 0 0 0 0 0 0 0 0 0 A0A9Q1CGU3 A0A9Q1CGU3_HOLLE Galaxin HOLleu_07095 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 1.0087 -5.3628 NDECCGNVTYDTTSSTCCTTGGS 0 21.2068 21.2068 0 0 0 17.2561 0 0 0 20.9012 20.9012 0 0 0 0 0 0 A0A9Q1CGY2 A0A9Q1CGY2_HOLLE Mitogen-activated protein kinase kinase kinase 10 HOLleu_07166 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; signal transduction [GO:0007165] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] 1 1.7 1.0248 -5.5496 SFHTMQENWRQ 23.6318 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CGY7 A0A9Q1CGY7_HOLLE Gamma-aminobutyric acid type B receptor subunit 1 HOLleu_07279 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) gamma-aminobutyric acid signaling pathway [GO:0007214] G protein-coupled receptor heterodimeric complex [GO:0038039] G protein-coupled GABA receptor activity [GO:0004965] 2 3 1.0015 -28.195 CNEGWHRSNFS;KLFGIVGILLLPDVLLLSL 0 0 0 0 0 0 0 0 0 18.8315 0 0 22.692 0 0 0 0 0 A0A9Q1CGY9 A0A9Q1CGY9_HOLLE Kinesin-like protein KIF16B HOLleu_08084 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225] centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] 1 0.2 0.86429 -0.068637 EGDEDSDT 0 22.7549 22.7549 0 0 0 0 0 0 0 0 0 20.0407 20.4575 20.4575 0 0 0 A0A9Q1CGZ6 A0A9Q1CGZ6_HOLLE E3 ubiquitin-protein ligase CHFR HOLleu_07039 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair [GO:0006302]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511] cell division site [GO:0032153]; cytosol [GO:0005829]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151] histone binding [GO:0042393]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 2 4.4 1.0117 -12.327 DGDEEDDDDVDVDH;DSNDDEDSTYEDG 0 0 0 0 0 0 0 0 0 21.9554 21.1704 21.1704 0 0 0 0 0 0 A0A9Q1CH17 A0A9Q1CH17_HOLLE Short-chain collagen C4 HOLleu_07336 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581]; extracellular space [GO:0005615] 1 2.7 1.0137 -2.6427 GEQDGSDQH 0 0 0 0 0 0 0 0 0 21.1867 0 0 0 0 0 0 0 0 A0A9Q1CH22 A0A9Q1CH22_HOLLE S-adenosylmethionine-dependent methyltransferase CRG1 HOLleu_07693 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] 1 2.6 1.0184 -23.777 KLYLKFRP 0 0 0 0 0 0 0 20.9303 20.9303 0 21.7311 21.7311 0 0 0 0 0 0 A0A9Q1CH32 A0A9Q1CH32_HOLLE Gamma-aminobutyric acid type B receptor subunit 1 HOLleu_07676 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) gamma-aminobutyric acid signaling pathway [GO:0007214] G protein-coupled receptor heterodimeric complex [GO:0038039] G protein-coupled GABA receptor activity [GO:0004965] 1 1.6 1.0266 -23.631 NIWYRQQNLEK 0 0 0 18.869 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CH53 A0A9Q1CH53_HOLLE Bromodomain adjacent to zinc finger domain protein 1A HOLleu_07747 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chromatin remodeling [GO:0006338]; positive regulation of DNA replication [GO:0045740]; regulation of DNA-templated transcription [GO:0006355]; regulation of heterochromatin formation [GO:0031445] CHRAC [GO:0008623]; nuclear chromosome [GO:0000228] DNA binding [GO:0003677]; metal ion binding [GO:0046872] 1 0.9 1.0124 -11.621 EEEEEEEEEDDEEEEEEE 0 18.2447 18.2447 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CH55 A0A9Q1CH55_HOLLE Heat shock protein HSP 90-alpha 1 HOLleu_07402 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to heat [GO:0034605]; protein stabilization [GO:0050821] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082] 1 1.1 0.86833 -0.068637 SKHNDDET 0 23.5628 23.5628 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CH61 A0A9Q1CH61_HOLLE Carboxypeptidase A2 HOLleu_07455 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] 2 3 1.0066 -6.1466 CYHTMQEIEDWMDG;GPGANGLK 22.2953 0 0 0 0 0 18.7088 0 0 25.0726 21.1403 21.1403 0 0 0 0 0 0 A0A9Q1CH62 A0A9Q1CH62_HOLLE C2H2-type domain-containing protein HOLleu_07324 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893] nucleoplasm [GO:0005654] 2 1.4 1 -2.9454 PEKKSKRKG;YFDSCDHWCSCC 0 0 0 0 0 0 0 0 0 0 0 0 21.6948 0 0 0 0 0 A0A9Q1CH64 A0A9Q1CH64_HOLLE Double zinc ribbon and ankyrin repeat-containing protein 1 HOLleu_07161 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) eye photoreceptor cell development [GO:0042462] cell projection [GO:0042995] metal ion binding [GO:0046872] 1 1 0.86525 -0.068637 MKCVFCMA 0 0 0 0 0 0 0 0 0 0 0 0 23.9747 0 0 0 0 0 A0A9Q1CH72 A0A9Q1CH72_HOLLE Dynein regulatory complex subunit 7 HOLleu_07179 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) flagellated sperm motility [GO:0030317] cytoskeleton [GO:0005856]; motile cilium [GO:0031514] 1 1.7 1.0168 -5.7538 PDVDDDGLDAFDEDE 0 26.0455 26.0455 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CHA1 A0A9Q1CHA1_HOLLE Neuronal acetylcholine receptor subunit alpha-7 HOLleu_07241 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; neuron projection [GO:0043005]; synapse [GO:0045202] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] 1 1.7 0.87826 -0.068637 MATPKRLV 0 0 0 0 0 0 0 0 0 0 21.9473 21.9473 0 0 0 0 0 0 A0A9Q1CHA6 A0A9Q1CHA6_HOLLE Uncharacterized protein HOLleu_07572 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.5 1.0079 -2.6427 KAPPKVVFR 0 0 0 0 0 0 0 0 0 20.3759 22.5593 22.5593 0 0 0 0 0 0 A0A9Q1CHE4 A0A9Q1CHE4_HOLLE Symplekin HOLleu_07589 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mRNA polyadenylation [GO:0006378] membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] 1 0.9 1.0184 -23.027 PKLIKLNPIVVKE 0 0 0 0 0 0 0 0 0 0 24.3619 24.3619 0 0 0 0 0 0 A0A9Q1CHF0 A0A9Q1CHF0_HOLLE Cysteine-rich motor neuron 1 protein HOLleu_08322 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] 1 1.7 1.012 -11.395 ECNCDEMDCQADPNCPGEM 0 19.8385 19.8385 0 0 0 0 0 0 17.2284 0 0 0 0 0 0 0 0 A0A9Q1CHF2 A0A9Q1CHF2_HOLLE Short-chain collagen C4 HOLleu_07335 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581]; extracellular space [GO:0005615] 1 3.3 1.0272 -23.631 YHQDEQDRNDQ 0 0 0 0 0 0 19.6488 19.683 19.683 0 0 0 0 0 0 0 0 0 A0A9Q1CHF7 A0A9Q1CHF7_HOLLE N-lysine methyltransferase KMT5A-B HOLleu_08340 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] methyltransferase activity [GO:0008168] 2 1.7 1.0053 -23.845 QNARQKAK;VFIRKITT 0 0 0 0 18.4588 18.4588 22.9324 22.2693 22.2693 0 0 0 0 0 0 0 0 0 A0A9Q1CHI1 A0A9Q1CHI1_HOLLE Synaptotagmin-14 HOLleu_07550 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.5 1.0071 -23.777 YGYDDESS 0 0 0 0 0 0 24.1606 23.9444 23.9444 0 0 0 0 0 0 0 0 0 A0A9Q1CHI9 A0A9Q1CHI9_HOLLE Nidogen-1 HOLleu_08398 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] basement membrane [GO:0005604]; membrane [GO:0016020] calcium ion binding [GO:0005509] 3 3 0.99675 -34.292 DCFASADGRDYQCQ;ESYQCTCNPGYEGNGYS;GYEGNGYSCSALDCSSCDA 21.1016 21.9971 21.9971 0 0 0 0 18.1428 18.701 22.5282 21.2167 21.2167 0 16.3577 16.3577 0 0 0 A0A9Q1CHJ7 A0A9Q1CHJ7_HOLLE Arf-GAP with dual PH domain-containing protein 1 HOLleu_08442 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] "GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" 1 1.1 0.97633 -0.068637 NSDSDCME 0 0 0 0 0 0 0 0 0 0 0 0 0 21.3881 21.3881 0 0 0 A0A9Q1CHL2 A0A9Q1CHL2_HOLLE Glutathione hydrolase 1 proenzyme HOLleu_07773 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutathione catabolic process [GO:0006751] plasma membrane [GO:0005886] glutathione hydrolase activity [GO:0036374] 1 3.7 1.0178 -5.6907 RVKIAAAVVIALIVVGLIIAVI 22.2658 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CHM0 A0A9Q1CHM0_HOLLE Serine/threonine-protein kinase Nek9 HOLleu_08506 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] centrosome [GO:0005813] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901] 2 8.9 0.99583 -0.38044 ERKLRVRARVRIRDRYRIRVRIRIV;KLRVRARVRIRDRYRIRVRIRIVQ 23.8113 0 0 0 0 0 0 0 0 0 18.5073 18.5073 0 0 0 0 0 0 A0A9Q1CHM9 A0A9Q1CHM9_HOLLE Multiple epidermal growth factor-like domains protein 11 HOLleu_08494 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] membrane [GO:0016020] scavenger receptor activity [GO:0005044] 1 2.8 1.0028 -4.979 CQADSYGENC 0 0 0 0 0 0 0 0 0 0 23.8206 23.8206 0 0 0 0 0 0 A0A9Q1CHP0 A0A9Q1CHP0_HOLLE Usherin HOLleu_08083 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell projection [GO:0042995]; membrane [GO:0016020] 1 0.3 1.0152 -22.715 DNPDGCEQCQCNPA 0 0 0 0 0 0 16.5623 15.0088 15.0088 18.9909 0 0 15.8982 0 0 0 0 0 A0A9Q1CHP4 A0A9Q1CHP4_HOLLE Cornifelin-like B HOLleu_07487 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.6 1.0035 -23.777 TNQPGAGG 0 20.0585 20.0585 0 0 0 0 0 0 0 20.9339 20.9339 0 0 0 0 0 0 A0A9Q1CHQ2 A0A9Q1CHQ2_HOLLE CCHC-type domain-containing protein HOLleu_07512 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 2.4 0.96491 -0.068637 GMTCTIGC 0 0 0 0 0 0 0 0 0 0 0 0 0 20.8871 20.8871 0 0 0 A0A9Q1CHQ7 A0A9Q1CHQ7_HOLLE Trace amine-associated receptor 7b HOLleu_08088 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] 1 3.4 0.98684 -0.30273 VTKTKLKIAFLL 0 0 0 21.7723 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CHT7 A0A9Q1CHT7_HOLLE CCAAT/enhancer-binding protein zeta HOLleu_08630 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] 1 1.8 1.0023 -4.125 DEFDEEGFGESDDGNPQCSD 0 0 0 0 0 0 0 0 0 0 21.2968 21.2968 0 0 0 0 0 0 A0A9Q1CHU1 A0A9Q1CHU1_HOLLE Serine/threonine-protein kinase D3 HOLleu_07608 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] 1 1.4 1.0092 -6.0118 RHCFEIQTKRTT 22.4068 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CHW1 A0A9Q1CHW1_HOLLE Circularly permutated Ras protein 1 HOLleu_08743 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165] COPII vesicle coat [GO:0030127] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; zinc ion binding [GO:0008270] 1 1.3 1.029 -23.631 TVSKAAAITGG 0 22.1333 22.1333 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CHW9 A0A9Q1CHW9_HOLLE Bcl-2-like protein 1 HOLleu_07810 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243] mitochondrial outer membrane [GO:0005741] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] 1 3.2 1.0164 -2.6427 TMCLLGPCC 0 23.3373 23.3373 0 0 0 0 0 0 23.2982 21.1211 21.1211 0 0 0 0 0 0 A0A9Q1CI02 A0A9Q1CI02_HOLLE Uncharacterized protein HOLleu_08272 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.2 1.0164 -2.6427 PPTVTGGLV 0 21.8626 21.8626 0 0 0 0 0 0 21.1401 21.2255 21.2255 18.8267 19.4059 19.4059 0 0 0 A0A9Q1CI07 A0A9Q1CI07_HOLLE Mis18-binding protein 1 HOLleu_08030 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "chromosome, centromeric region [GO:0000775]" 1 0.8 1.0007 -4.979 TGSEANCSDE 0 23.351 23.351 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CI81 A0A9Q1CI81_HOLLE Extracellular matrix protein FRAS1 HOLleu_08874 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion [GO:0007155]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020] heparin binding [GO:0008201]; integrin binding [GO:0005178] 1 0.7 1.0039 -23.777 QSCDSACD 0 0 0 0 0 0 0 0 0 0 0 0 20.1634 20.4615 20.4615 0 0 0 A0A9Q1CIB5 A0A9Q1CIB5_HOLLE Ly6/PLAUR domain-containing protein 1 HOLleu_08983 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.9 1.0251 -23.723 WGCVECCEG 0 0 0 0 0 0 0 0 0 20.8073 0 0 17.2182 0 0 0 0 0 A0A9Q1CIC1 A0A9Q1CIC1_HOLLE Zinc transporter 6-A HOLleu_07937 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion transport [GO:0006829] Golgi apparatus [GO:0005794]; membrane [GO:0016020] monoatomic cation transmembrane transporter activity [GO:0008324] 1 1.8 0.96512 -0.068637 VSTSSKSS 0 0 0 0 0 0 0 0 0 0 21.6081 21.6081 21.2866 0 0 0 0 0 A0A9Q1CIC5 A0A9Q1CIC5_HOLLE Kinetochore protein SPC25 HOLleu_08192 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell division [GO:0051301]; chromosome segregation [GO:0007059] Ndc80 complex [GO:0031262]; nucleus [GO:0005634] 1 5.6 1.0265 -23.027 FVVAIRKKFKKGL 0 0 0 0 17.4273 17.4273 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CIF1 A0A9Q1CIF1_HOLLE Cholesterol 24-hydroxylase HOLleu_08558 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholesterol catabolic process [GO:0006707] membrane [GO:0016020] cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506] 1 4.6 1.0112 -2.2078 ALIEARVVLAKLLQRLKFKLVPD 0 0 0 0 0 0 0 0 0 23.3477 23.3435 23.3435 0 0 0 0 0 0 A0A9Q1CIF7 A0A9Q1CIF7_HOLLE Nesprin-1 HOLleu_08998 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nuclear migration [GO:0007097] cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640] actin filament binding [GO:0051015] 2 0.4 1.0068 -23.839 RWEELVHQEGDRKRKLDANLEYIR;YVPSTGKLKIA 21.8533 0 0 17.8865 0 0 19.7432 19.6709 19.6709 21.1704 20.8766 20.8766 19.5419 19.9773 19.9773 0 0 17.6878 A0A9Q1CIG3 A0A9Q1CIG3_HOLLE MAP3K12-binding inhibitory protein 1 HOLleu_09077 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.8 1.0039 -23.777 QSMSEDTD 0 0 0 0 0 0 0 0 0 0 18.9896 18.9896 19.487 0 0 0 0 0 A0A9Q1CIG9 A0A9Q1CIG9_HOLLE Paired box protein Pax-9 HOLleu_08594 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.9 1.0155 -2.6427 GSKAAAAAA 0 22.5562 22.5562 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CIH5 A0A9Q1CIH5_HOLLE Uncharacterized protein HOLleu_08312 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 14.6 1.0128 -6.0779 SDGDGDGDDGGGGG 0 22.0522 22.0522 0 0 0 0 0 0 21.2668 0 0 0 0 0 0 0 0 A0A9Q1CIK2 A0A9Q1CIK2_HOLLE Uncharacterized protein HOLleu_09160 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 10.8 1.0133 -6.0779 QDVDSDSWEDSADD 0 0 0 0 0 0 0 0 0 24.2014 0 0 0 0 0 0 0 0 A0A9Q1CIP5 A0A9Q1CIP5_HOLLE Uncharacterized protein HOLleu_08685 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.1 1.0225 -23.675 VPLLRVVNVR 0 18.4118 18.4118 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CIP6 A0A9Q1CIP6_HOLLE B box-type domain-containing protein HOLleu_04766 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 1 1.4 0.96532 -0.068637 RPLPIGGK 0 0 0 0 0 0 0 0 0 0 21.4331 21.4331 0 0 0 0 0 0 A0A9Q1CIQ1 A0A9Q1CIQ1_HOLLE Cholesterol 24-hydroxylase HOLleu_09262 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholesterol catabolic process [GO:0006707] membrane [GO:0016020] cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506] 1 1.6 0.95977 -0.068637 IFVIFAVH 0 0 0 0 0 0 0 0 0 0 22.2038 22.2038 0 0 0 0 0 0 A0A9Q1CIR9 A0A9Q1CIR9_HOLLE Neurogenic locus notch-like protein 2 HOLleu_09193 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 2 6.7 1.0034 -5.0073 QCTDDDCHCEHED;REESCETCFCRNGDWTCTE 24.0073 23.1443 23.1443 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CIS2 A0A9Q1CIS2_HOLLE Multiple epidermal growth factor-like domains protein 6 HOLleu_08491 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] membrane [GO:0016020] scavenger receptor activity [GO:0005044] 1 3.8 1.0047 -4.125 ECSQSCPNGYFGENCMYECR 0 23.6503 23.6503 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CIY4 A0A9Q1CIY4_HOLLE Suppressor of cytokine signaling 5 HOLleu_08613 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] phosphatidylinositol 3-kinase complex [GO:0005942] 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] 1 1.8 0.94915 -0.068637 VPNRGVGR 0 0 0 0 0 0 0 0 0 0 0 0 21.3462 0 0 0 0 0 A0A9Q1CJ09 A0A9Q1CJ09_HOLLE RNA helicase aquarius HOLleu_08947 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013] helicase activity [GO:0004386]; mRNA binding [GO:0003729] 1 0.5 1.0047 -23.777 GYGDPGAA 18.9102 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJ12 A0A9Q1CJ12_HOLLE WASH complex subunit 4 HOLleu_04821 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endosomal transport [GO:0016197]; endosome organization [GO:0007032] endosome [GO:0005768]; WASH complex [GO:0071203] 1 0.8 1.0035 -4.979 HNCVEQNFDD 23.7127 23.6213 23.6213 0 15.8048 15.8048 0 0 0 23.0675 22.265 22.265 17.1838 17.621 17.621 0 0 0 A0A9Q1CJ17 A0A9Q1CJ17_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_08508 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] centrosome [GO:0005813]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674] 1 1.2 1.0103 -6.0118 YDVCCDMWALGC 0 0 0 0 0 0 0 0 0 20.7627 20.6545 20.6545 0 0 0 0 0 0 A0A9Q1CJ18 A0A9Q1CJ18_HOLLE Zinc finger protein DPF3 HOLleu_08360 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of transcription by RNA polymerase II [GO:0045944] MLL3/4 complex [GO:0044666] histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] 1 5.1 1.0072 -2.7235 CKSCGLCGTSDNDDQLLFCDD 0 0 0 0 0 0 0 0 0 0 23.8039 23.8039 0 0 0 0 0 0 A0A9Q1CJ19 A0A9Q1CJ19_HOLLE tRNA pseudouridine(55) synthase (EC 5.4.99.25) HOLleu_08965 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] 1 4.4 1.0094 -5.3628 QVINKLKEKSNEELKEMFSIPPT 0 21.5581 21.5581 0 0 0 0 0 0 0 0 0 16.9346 0 0 0 0 0 A0A9Q1CJ36 A0A9Q1CJ36_HOLLE Thrombospondin-1 HOLleu_08399 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] 1 1.8 1.008 -2.7235 CFYGVECRSHHDGTYECGSCP 0 0 0 0 0 0 21.8015 21.5383 21.5383 0 0 0 0 0 0 0 0 0 A0A9Q1CJ56 A0A9Q1CJ56_HOLLE Uncharacterized protein HOLleu_08435 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 34.2 0.94972 -0.068637 YFTEEIRFRAFFSQPYGFRIYIRHI 0 21.4045 21.4045 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJ57 A0A9Q1CJ57_HOLLE Transport and Golgi organization protein 1-like HOLleu_08580 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789] 2 0.7 1.0111 -2.2424 PFRGPPGG;RPPSRPVR 22.047 23.6982 23.6982 18.9896 20.5871 20.5871 0 0 0 23.0631 22.516 22.516 18.9841 0 0 18.5629 0 19.2047 A0A9Q1CJ82 A0A9Q1CJ82_HOLLE Prothrombin HOLleu_04950 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] 2 2.5 1.0082 -8.1923 FYDGFNTST;SCVYTETGYMC 0 23.5544 23.5544 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJB5 A0A9Q1CJB5_HOLLE Helicase ARIP4 HOLleu_05009 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386] 1 0.6 1.0242 -23.723 NLMEYWCMV 0 0 0 0 0 0 0 18.9474 18.9474 0 0 0 0 0 0 0 0 0 A0A9Q1CJD3 A0A9Q1CJD3_HOLLE Tyrosine-protein kinase receptor (EC 2.7.10.1) HOLleu_08572 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 1 0.7 0.95 -0.068637 VGQAGHDA 0 0 0 0 0 0 0 23.1072 23.1072 0 23.6926 23.6926 0 0 0 0 0 0 A0A9Q1CJE4 A0A9Q1CJE4_HOLLE Hepatocyte nuclear factor 3-beta HOLleu_08592 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 3.3 1.0146 -5.7538 SQPSSSAEGISSETP 0 23.2026 23.2026 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJE5 A0A9Q1CJE5_HOLLE Transcriptional-regulating factor 1 HOLleu_09201 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; transcription regulator complex [GO:0005667] calcium ion binding [GO:0005509]; transcription corepressor activity [GO:0003714] 1 0.4 0.95028 -0.068637 SGHPAPMG 0 0 0 0 0 0 0 0 0 0 0 0 0 20.3912 20.3912 0 0 0 A0A9Q1CJF7 A0A9Q1CJF7_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_08909 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 2.8 1.0004 -47.5 SWDHNDAI;WLNHNCHHS 0 0 0 17.7681 0 16.2783 0 0 0 0 0 0 0 0 0 17.3392 15.93 15.93 A0A9Q1CJF8 A0A9Q1CJF8_HOLLE HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HOLleu_09182 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of apoptotic process [GO:0043066]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737]; membrane [GO:0016020] ubiquitin protein ligase activity [GO:0061630] 1 2.5 1.008 -2.7235 FYQRNGLKCAVSKEDNILVEI 0 22.6787 22.6787 18.6454 19.8694 19.8694 21.3964 21.0544 21.0544 23.3637 0 0 21.1765 20.8521 20.8521 17.8327 0 19.0071 A0A9Q1CJI0 A0A9Q1CJI0_HOLLE Leucine-rich repeats and immunoglobulin-like domains protein 3 HOLleu_05195 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.7 0.93989 -0.068637 NSDCDSME 23.4691 23.077 23.077 0 0 0 0 0 0 18.2804 0 0 20.4234 21.7369 21.7369 0 0 0 A0A9Q1CJI6 A0A9Q1CJI6_HOLLE S-antigen protein HOLleu_05074 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 1.0094 -6.0779 DRGSQSCTVEFEGS 0 26.7509 26.7509 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJI8 A0A9Q1CJI8_HOLLE Plexin-A1 HOLleu_05140 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) motor neuron axon guidance [GO:0008045]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sensory neuron axon guidance [GO:0097374] semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] 1 2.2 1.0108 -2.6427 ENSYACACN 21.1 24.0078 24.0078 0 17.2758 0 0 0 0 23.2082 22.8599 22.8599 23.3063 0 0 0 0 0 A0A9Q1CJK1 A0A9Q1CJK1_HOLLE NACHT domain- and WD repeat-containing protein 1 HOLleu_05406 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 2.8 1.0049 -24.503 FESEYNRRKLRQLPYH;YFPRLLKN 20.3977 22.8152 22.8152 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJM8 A0A9Q1CJM8_HOLLE IQ motif and SEC7 domain-containing protein 1 HOLleu_05220 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] guanyl-nucleotide exchange factor activity [GO:0005085] 3 2.2 1.0084 -6.2793 PRQLPKAR;SSSTTGDMVYDD;TSKKVVVKVTL 0 24.0511 24.0511 19.4069 20.3694 20.3694 21.232 0 0 23.8535 23.046 23.046 0 19.937 19.937 18.7896 0 19.5527 A0A9Q1CJP2 A0A9Q1CJP2_HOLLE High mobility group protein B3 HOLleu_05329 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] DNA binding [GO:0003677] 1 3.8 1.0159 -16.819 EDYDDDEYEEEDYDEEA 23.7961 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJP5 A0A9Q1CJP5_HOLLE Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Receptor-interacting serine/threonine-protein kinase 5) HOLleu_04795 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to fibroblast growth factor stimulus [GO:0044344]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 1 1.7 1.0112 -5.5027 ECWDLMVSCWAGETTH 0 22.1863 22.1863 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJQ6 A0A9Q1CJQ6_HOLLE Polycystic kidney disease 1-related protein HOLleu_08932 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 6 3.3 0.99892 -41.939 DCAGVCNGGADYDCAGECNG;DGGWFDWEDEWYDWYYWWDDWSY;GGWFDWEDEWYDWYY;LCEEFDYNEHDWYSYYWDYS;SCGSDTCS;WSYSESESESWSSSWSYSESESE 22.8388 23.0453 23.0453 0 0 0 0 22.2615 22.2615 0 17.5013 17.5013 0 0 0 0 0 0 A0A9Q1CJR4 A0A9Q1CJR4_HOLLE RBR-type E3 ubiquitin transferase (EC 2.3.2.31) HOLleu_05370 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] 1 1.2 1.0288 -23.442 NGGCMHMSCHFC 0 0 0 0 0 0 0 0 0 0 0 0 21.8827 0 0 0 0 0 A0A9Q1CJU2 A0A9Q1CJU2_HOLLE ATP-dependent RNA helicase DDX52 HOLleu_09177 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytosol [GO:0005829] ATP binding [GO:0005524]; RNA helicase activity [GO:0003724] 1 4.9 0.93478 -0.068637 KGGRMGGK 0 0 0 16.8379 0 0 17.441 0 0 20.9978 19.5651 19.5651 0 0 0 0 0 0 A0A9Q1CJV4 A0A9Q1CJV4_HOLLE G-patch domain and KOW motifs-containing protein HOLleu_05618 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] nucleic acid binding [GO:0003676] 1 1.8 1.0228 -23.631 REERRENEDSD 0 0 0 0 0 0 24.6779 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJY2 A0A9Q1CJY2_HOLLE Protein SSUH2-like HOLleu_05506 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.3 1.0242 -23.723 FQECDECNG 0 0 0 15.223 0 0 0 0 0 20.5597 0 0 19.1809 0 0 0 0 0 A0A9Q1CJY5 A0A9Q1CJY5_HOLLE Secreted protein HOLleu_05705 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 14.9 1.0167 -22.715 YFVPTMKTFCKLLF 0 18.9734 18.9734 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CJZ5 A0A9Q1CJZ5_HOLLE "Alpha-(1,6)-fucosyltransferase" HOLleu_08961 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) N-glycan fucosylation [GO:0036071]; protein N-linked glycosylation [GO:0006487] membrane [GO:0016020] alpha-(1->6)-fucosyltransferase activity [GO:0046921] 1 4.4 1.019 -17.224 LKNIVQGRLHYLQNPK 0 0 0 0 0 0 0 0 0 21.2349 21.1819 21.1819 0 0 0 0 0 0 A0A9Q1CK03 A0A9Q1CK03_HOLLE Fibropellin-1 HOLleu_04948 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; response to stimulus [GO:0050896] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 4.2 1.0157 -22.715 GFQGINCTEDVNEC 0 0 0 0 0 0 0 0 0 20.6297 0 0 0 0 0 0 0 0 A0A9Q1CK04 A0A9Q1CK04_HOLLE Mitochondrial substrate carrier family protein ucpB HOLleu_05004 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 1 2.5 0.95429 -0.068637 EPIKRLLG 0 0 0 0 0 0 0 0 0 0 22.8323 22.8323 0 0 0 0 0 0 A0A9Q1CK28 A0A9Q1CK28_HOLLE DALR anticodon-binding domain-containing protein 3 HOLleu_05801 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) arginyl-tRNA aminoacylation [GO:0006420]; tRNA C3-cytosine methylation [GO:0106217] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; tRNA binding [GO:0000049] 1 4.1 0.98601 -0.20876 DRSCTFQKTLTRHLSLGTKVFYQG 0 22.0914 22.0914 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CK39 A0A9Q1CK39_HOLLE Uncharacterized protein HOLleu_09181 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.2 1.0104 -6.0118 QGDESSDESENS 0 0 0 0 0 0 0 0 0 21.3703 0 0 0 0 0 0 0 0 A0A9Q1CK50 A0A9Q1CK50_HOLLE Zinc metalloproteinase nas-39 HOLleu_05863 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.3 1.0123 -11.621 DCTNNFCEDGCGDSQYFT 0 0 0 0 0 0 22.0828 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CK56 A0A9Q1CK56_HOLLE RING-type E3 ubiquitin transferase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAD18) HOLleu_05502 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) postreplication repair [GO:0006301]; protein monoubiquitination [GO:0006513] nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505] metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630] 1 1.3 1.0136 -2.6427 SPPSNVPAT 0 0 0 0 0 0 0 23.3088 23.3088 0 0 0 0 0 0 0 0 0 A0A9Q1CK65 A0A9Q1CK65_HOLLE RNA-binding protein 5 HOLleu_05522 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA splicing, via spliceosome [GO:0000398]" nucleus [GO:0005634] RNA binding [GO:0003723] 1 1.6 1.0145 -2.6427 SYGGGSDSE 23.5702 25.1244 25.1244 0 0 0 0 0 0 24.5567 24.3614 24.3614 0 0 0 0 0 0 A0A9Q1CK66 A0A9Q1CK66_HOLLE Metalloproteinase inhibitor 2 HOLleu_05062 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020] 1 4.2 1.0166 -23.027 EFYSPSSFCGTHF 0 0 0 0 0 0 0 0 0 18.9662 18.4323 18.4323 0 0 0 0 0 0 A0A9Q1CK67 A0A9Q1CK67_HOLLE Metastasis-associated protein MTA1 HOLleu_09093 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of transcription by RNA polymerase II [GO:0000122] NuRD complex [GO:0016581] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] 1 1.5 1.0262 -5.5496 MGMGGQVSMPG 0 23.3061 23.3061 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CK76 A0A9Q1CK76_HOLLE N-acetylglucosamine-6-sulfatase HOLleu_05925 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glycosaminoglycan metabolic process [GO:0030203] glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449] 1 1.5 1.0063 -23.777 GHMNGAHF 0 0 0 16.9234 18.1176 18.1176 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CK81 A0A9Q1CK81_HOLLE Transporter HOLleu_04904 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sodium ion transmembrane transport [GO:0035725] membrane [GO:0016020] symporter activity [GO:0015293] 1 1.5 1.0048 -4.979 WGTCEGDWND 18.8419 20.6284 20.6284 0 0 0 0 0 0 22.837 0 0 0 0 0 0 0 0 A0A9Q1CK88 A0A9Q1CK88_HOLLE C2H2-type domain-containing protein HOLleu_05154 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA binding [GO:0003677] 1 1.7 1.0224 -23.631 FYRCDCRIHEM 0 0 0 0 0 0 0 0 0 0 0 0 0 20.5775 20.5775 0 0 0 A0A9Q1CK90 A0A9Q1CK90_HOLLE Thyroid transcription factor 1 HOLleu_09285 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 2.7 0.98214 -0.068637 QMNMNMNM 0 0 0 0 0 0 22.8555 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CK97 A0A9Q1CK97_HOLLE Cadherin EGF LAG seven-pass G-type receptor 2 HOLleu_05968 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; flotillin complex [GO:0016600] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] 2 0.8 1.0056 -24.389 EECDENFWGH;YDSCPRRFKANLWWP 0 0 0 0 0 0 0 0 0 18.626 0 0 16.4507 0 0 0 0 0 A0A9Q1CKF0 A0A9Q1CKF0_HOLLE DnaJ homolog subfamily C member 2 HOLleu_05851 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 'de novo' cotranslational protein folding [GO:0051083]; chromatin organization [GO:0006325]; regulation of translational fidelity [GO:0006450] cytosol [GO:0005829] Hsp70 protein binding [GO:0030544]; ribosome binding [GO:0043022] 2 3.5 1.006 -6.2292 DSGQDGGDDSESMSEE;GDDSESMSEEEDNIED 0 0 0 0 0 0 23.2324 23.0538 23.0538 0 0 0 0 0 0 0 0 0 A0A9Q1CKF1 A0A9Q1CKF1_HOLLE Reverse transcriptase domain-containing protein HOLleu_04798 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.9 1.0145 -6.0779 DTDDSQDSMDEPPN 0 0 0 0 20.1882 20.1882 16.8425 16.2848 16.2848 22.3161 0 0 0 23.8499 23.8499 0 0 0 A0A9Q1CKF8 A0A9Q1CKF8_HOLLE Uncharacterized protein HOLleu_09279 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 13.6 1.0008 -4.564 DKCEDESEDECEDVSEDES 0 0 0 0 0 0 0 21.944 21.944 0 0 0 0 0 0 0 0 0 A0A9Q1CKH9 A0A9Q1CKH9_HOLLE Titin HOLleu_05837 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.2 1.0263 -5.5496 CCVDFGMTPMS 0 0 0 0 0 0 0 0 0 0 25.5776 25.5776 0 0 0 0 0 0 A0A9Q1CKI3 A0A9Q1CKI3_HOLLE Plexin-A1 HOLleu_04854 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) motor neuron axon guidance [GO:0008045]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sensory neuron axon guidance [GO:0097374] plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] 1 0.7 1.0121 -6.0118 QAEENTQMTFVS 0 0 0 0 0 0 0 21.4674 21.4674 0 0 0 0 0 0 0 0 0 A0A9Q1CKI8 A0A9Q1CKI8_HOLLE Nucleolar protein 8 HOLleu_05857 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 1.0133 -0.068637 RSDDTCEC 19.9658 20.7301 20.7301 0 0 0 0 0 0 20.093 19.7161 19.7161 0 0 0 0 0 0 A0A9Q1CKJ3 A0A9Q1CKJ3_HOLLE Myb-like domain-containing protein HOLleu_04871 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] 1 2.3 1.0145 -2.6427 TPVRTVKLR 0 0 0 0 0 0 22.5491 0 0 0 0 0 0 0 0 18.8493 0 0 A0A9Q1CKR8 A0A9Q1CKR8_HOLLE Glycerate kinase HOLleu_05256 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] cytoplasm [GO:0005737] glycerate kinase activity [GO:0008887] 2 3.2 0.99656 -0.4572 QRKLVSKKSI;VGANSVQH 21.0477 23.1831 23.1831 0 0 0 20.426 0 0 0 0 0 19.11 0 0 0 0 0 A0A9Q1CKS5 A0A9Q1CKS5_HOLLE Neural Wiskott-Aldrich syndrome protein HOLleu_06032 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin filament polymerization [GO:0030041] actin filament [GO:0005884]; cytoplasm [GO:0005737]; nucleus [GO:0005634] actin binding [GO:0003779] 1 4.8 1.0023 -4.125 SDEDDSDEEDFEDDDDEWDD 20.2072 21.9739 21.9739 0 0 0 0 0 0 0 22.121 22.121 0 0 0 0 0 0 A0A9Q1CKS6 A0A9Q1CKS6_HOLLE Uncharacterized protein HOLleu_06113 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 0.98352 -0.14157 SRIIPIPKKPI 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21.5571 21.5571 A0A9Q1CKT1 A0A9Q1CKT1_HOLLE C2H2-type domain-containing protein HOLleu_05024 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 2.5 1 -28.654 KRRIRTYPNL;NLRKPAALPV 0 0 0 0 0 0 19.6027 0 0 23.3109 0 0 0 19.7247 19.7247 0 0 0 A0A9Q1CKU6 A0A9Q1CKU6_HOLLE Cilia- and flagella-associated protein 54 HOLleu_05330 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cilium assembly [GO:0060271] motile cilium [GO:0031514] 1 0.4 1.0059 -6.2493 DACGDAEMQAEFF 0 0 0 0 0 0 0 22.6826 22.6826 0 0 0 0 0 0 0 0 0 A0A9Q1CKV6 A0A9Q1CKV6_HOLLE Laminin subunit beta-1 HOLleu_05082 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] basement membrane [GO:0005604] 1 0.7 1.0065 -6.2493 QCNGHADECEQTT 0 0 0 0 0 0 0 0 0 26.7312 25.2635 25.2635 0 0 0 0 0 0 A0A9Q1CKX6 A0A9Q1CKX6_HOLLE Reverse transcriptase domain-containing protein HOLleu_05600 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.6 1.0076 -6.2493 INGIRNSLDFKTT 0 0 0 0 0 0 0 0 0 22.4485 0 0 0 0 0 0 0 0 A0A9Q1CKY0 A0A9Q1CKY0_HOLLE Uncharacterized protein HOLleu_06062 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.3 1.0066 -0.068637 TSEGEDGF 0 0 0 0 0 0 0 0 0 22.0311 0 0 0 0 0 0 0 0 A0A9Q1CKY2 A0A9Q1CKY2_HOLLE "UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase 3" HOLleu_06239 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi apparatus [GO:0005794] UDP-xylosyltransferase activity [GO:0035252] 1 6.8 1.0131 -10.943 FYLRANDKTERFVRTWRHDL 0 21.1279 21.1279 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CKZ7 A0A9Q1CKZ7_HOLLE C2H2-type domain-containing protein HOLleu_05159 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 1 0.9 1.016 -2.6427 QHCVCSYCG 0 0 0 0 0 0 18.0217 0 0 22.4763 21.901 21.901 0 0 0 0 0 0 A0A9Q1CL00 A0A9Q1CL00_HOLLE Forkhead box protein P1 HOLleu_05366 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.9 1.0151 -5.5027 HGLLLSGDEAAFTATT 20.479 23.6981 23.6981 0 17.1231 17.1231 19.0628 19.306 19.306 19.8381 20.4157 20.4157 19.1567 18.7729 18.7729 15.8282 0 0 A0A9Q1CL21 A0A9Q1CL21_HOLLE Protein SHQ1 homolog HOLleu_06149 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) box H/ACA snoRNP assembly [GO:0000493] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] unfolded protein binding [GO:0051082] 2 3.6 1.0117 -13.476 DASEDETDSDESDEDDRDASDE;DSDESDEDDRDASDENSDED 0 0 0 0 0 0 0 0 0 0 21.2913 21.2913 0 18.5729 18.5729 0 0 0 A0A9Q1CL28 A0A9Q1CL28_HOLLE Neurogenic locus notch-like protein 1 HOLleu_05678 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell communication [GO:0007154] membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.8 1.0219 -23.675 CHDEPCLNGG 0 19.4404 19.4404 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CL37 A0A9Q1CL37_HOLLE Uncharacterized protein HOLleu_05731 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 1.8 1.0031 -4.125 CVEKPKDWDRYIPALLFAYR 0 0 0 0 0 0 0 0 0 23.3543 0 0 0 0 0 0 0 0 A0A9Q1CL48 A0A9Q1CL48_HOLLE Short-chain collagen C4 HOLleu_06295 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581]; extracellular space [GO:0005615] 1 4.4 1.0156 -5.7538 GCSTAYTPYYSGQCF 19.8347 20.6356 20.6356 0 0 0 0 0 0 21.4324 20.8022 20.8022 0 0 0 0 0 0 A0A9Q1CL65 A0A9Q1CL65_HOLLE Nidogen-2 HOLleu_05787 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] 1 2.8 0.99776 -4.564 EDGAMSECTDDNGEVASAT 0 20.537 20.537 0 0 0 0 0 0 21.3194 0 0 0 0 0 0 0 0 A0A9Q1CL91 A0A9Q1CL91_HOLLE Short-chain collagen C4 HOLleu_06286 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581]; extracellular space [GO:0005615] 1 2.4 0.9871 -0.068637 TSTFANWN 0 23.7656 23.7656 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CL93 A0A9Q1CL93_HOLLE DUF4200 domain-containing protein HOLleu_05190 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 1.0071 -23.777 RPSLSRSS 0 0 0 19.9553 0 0 0 0 0 23.1005 0 0 0 0 0 0 0 0 A0A9Q1CLF2 A0A9Q1CLF2_HOLLE Tubulin monoglycylase TTLL3 HOLleu_05453 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cilium assembly [GO:0060271]; cilium movement [GO:0003341]; protein modification process [GO:0036211] axoneme [GO:0005930]; microtubule cytoskeleton [GO:0015630] "protein-glycine ligase activity, initiating [GO:0070736]" 3 3.7 1.0007 -28.337 DMNENNNNHNNGGECEVGEYSV;GCHGDSDDGDE;KPGAKSRG 0 0 0 0 0 0 0 0 0 0 0 23.1275 0 23.1404 23.1404 0 0 0 A0A9Q1CLG9 A0A9Q1CLG9_HOLLE Sarcospan HOLleu_05689 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dystrophin-associated glycoprotein complex [GO:0016010]; sarcolemma [GO:0042383] 1 3.7 1.014 -6.0118 EHVYEDILDCES 0 0 0 0 0 0 0 0 0 23.9505 0 0 0 0 0 0 0 0 A0A9Q1CLH1 A0A9Q1CLH1_HOLLE Transcription factor TFIIIB component B''-like HOLleu_06007 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) RNA polymerase III preinitiation complex assembly [GO:0070898] transcription factor TFIIIB complex [GO:0000126] TFIIIC-class transcription factor complex binding [GO:0001156] 1 1.1 1.0152 -6.0118 PEDEEEMEEMTS 20.8943 0 0 0 0 0 0 0 0 23.7324 19.5539 19.5539 0 0 0 0 0 0 A0A9Q1CLJ4 A0A9Q1CLJ4_HOLLE Neural Wiskott-Aldrich syndrome protein HOLleu_06031 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin filament organization [GO:0007015] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] actin binding [GO:0003779] 1 2.1 1.0262 -5.5496 TDSEEYDSDDW 0 0 0 0 0 0 21.0943 20.8461 20.8461 0 0 0 0 0 0 0 0 0 A0A9Q1CLJ9 A0A9Q1CLJ9_HOLLE 5-hydroxytryptamine receptor 2B HOLleu_06488 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] C-C chemokine receptor activity [GO:0016493] 1 2.6 1.0128 -2.6427 ARKRRLRTT 0 0 0 21.4708 18.8742 18.8742 0 0 0 0 0 0 0 0 0 18.9433 0 20.3351 A0A9Q1CLL3 A0A9Q1CLL3_HOLLE Tissue inhibitor of metalloproteinase HOLleu_06089 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020] 1 3.3 1.0152 -2.6427 CDCHVHTCG 0 0 0 0 0 0 0 0 0 0 0 0 21.5271 21.013 21.013 0 0 0 A0A9Q1CLM3 A0A9Q1CLM3_HOLLE CCHC-type zinc finger nucleic acid binding protein HOLleu_06694 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of cytoplasmic translation [GO:2000767] cytoplasm [GO:0005737] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; single-stranded RNA binding [GO:0003727]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270] 2 6.7 1.0041 -26.419 GGGGGKAC;SGGGGGSGC 21.0716 0 0 0 0 0 0 0 0 22.8995 22.716 22.716 0 0 0 0 0 0 A0A9Q1CLN0 A0A9Q1CLN0_HOLLE Amine oxidase domain-containing protein HOLleu_06117 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) oxidoreductase activity [GO:0016491] 1 1.3 1.0222 -23.723 MDDVDQTKC 0 0 0 0 0 0 0 0 0 0 19.896 19.896 0 17.2463 17.2463 0 0 0 A0A9Q1CLP4 A0A9Q1CLP4_HOLLE ubiquitinyl hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme A) HOLleu_06647 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cysteine-type deubiquitinase activity [GO:0004843] 1 2.1 1.0135 -6.0118 RRHCMDYMMKNC 22.3332 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CLS3 A0A9Q1CLS3_HOLLE Constitutive coactivator of PPAR-gamma-like protein 1-like HOLleu_06218 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] 1 0.7 0.98734 -0.068637 VVKAPPLP 0 0 0 21.0518 19.6868 19.6868 0 21.0691 21.0691 0 0 0 0 0 0 21.3599 0 18.9482 A0A9Q1CLT2 A0A9Q1CLT2_HOLLE "UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase 3" HOLleu_06238 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi apparatus [GO:0005794]; membrane [GO:0016020] UDP-xylosyltransferase activity [GO:0035252] 1 6.7 1.0094 -5.3628 PKIITLEYKRLSFQETHSEDLRE 21.4077 0 0 0 0 0 0 0 0 0 0 0 0 19.0995 19.0995 0 0 0 A0A9Q1CLT9 A0A9Q1CLT9_HOLLE "Alpha-2,8-sialyltransferase 8B" HOLleu_00111 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]" 1 2.2 0.98742 -0.068637 FCSIDDVE 0 0 0 0 0 0 21.931 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CLW9 A0A9Q1CLW9_HOLLE Transcriptional repressor tup11 HOLleu_05988 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.5 0.98795 -0.068637 DASGAAMY 0 0 0 0 18.9281 0 18.2737 0 0 22.9502 0 0 0 0 0 0 0 0 A0A9Q1CLZ3 A0A9Q1CLZ3_HOLLE Fibropellin-1 HOLleu_06046 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 0.9 1.0133 -5.7538 TCEPDNPCLNGGTCT 0 0 0 0 20.334 15.2888 0 0 0 0 0 0 21.6287 21.7312 21.7312 0 0 0 A0A9Q1CM51 A0A9Q1CM51_HOLLE FERM domain-containing protein 4A HOLleu_06848 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment of epithelial cell polarity [GO:0090162] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoskeleton [GO:0005856] 2 2.5 1.0048 -25.931 PNISKKVRK;YQSLQRLPRSGKGNNGSIEDFRI 0 0 0 0 18.8391 18.8391 0 0 0 0 0 0 22.8198 0 0 0 0 0 A0A9Q1CM63 A0A9Q1CM63_HOLLE Uncharacterized protein HOLleu_06476 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8 1.0049 -6.2493 EEECDSAISDGSS 0 22.0174 22.0174 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CM95 A0A9Q1CM95_HOLLE Uncharacterized protein HOLleu_06310 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 0.98125 -0.068637 SMCPADCM 0 25.0851 25.0851 0 0 0 0 0 0 22.1546 21.7323 21.7323 0 0 0 0 0 0 A0A9Q1CMA4 A0A9Q1CMA4_HOLLE Histone-lysine N-methyltransferase SETMAR HOLleu_06329 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] chromosome [GO:0005694]; nucleus [GO:0005634] histone H3K9 methyltransferase activity [GO:0046974]; zinc ion binding [GO:0008270] 1 3.3 1.0128 -2.6427 GMCHCGETC 0 0 0 0 0 0 0 0 0 23.9945 23.423 23.423 0 0 0 0 0 0 A0A9Q1CMG5 A0A9Q1CMG5_HOLLE Uncharacterized protein HOLleu_00601 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.7 1.0021 -4.979 MSTNGMATAY 0 21.8625 21.8625 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CMG8 A0A9Q1CMG8_HOLLE Neuronal cell adhesion molecule HOLleu_06677 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axon guidance [GO:0007411]; brain development [GO:0007420] axon [GO:0030424]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] 1 0.6 1.0055 -23.777 TGDMTPPG 0 0 0 0 0 0 18.186 18.0806 18.0806 0 0 0 0 0 0 0 0 0 A0A9Q1CMH2 A0A9Q1CMH2_HOLLE Slit-like 3 protein HOLleu_00623 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] 1 6.7 1.0218 -23.723 LLKKTTKLK 0 0 0 0 0 0 19.2819 0 0 0 19.8306 19.8306 0 0 0 0 0 0 A0A9Q1CMP0 A0A9Q1CMP0_HOLLE Peregrin HOLleu_06809 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleus [GO:0005634] metal ion binding [GO:0046872] 1 0.9 1.0159 -6.0118 EEVEYDMDEEDY 21.1974 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CMP4 A0A9Q1CMP4_HOLLE Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein HOLleu_06174 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 0.99851 -4.7869 CDSTQNHQDCEYGEEEWT 0 23.9211 23.9211 0 0 0 0 0 0 23.8718 23.2631 23.2631 0 0 0 0 0 0 A0A9Q1CMQ1 A0A9Q1CMQ1_HOLLE Angiopoietin-related protein 1 HOLleu_06532 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.6 1.0279 -23.027 DDSEWCEDPFSSH 0 0 0 0 0 0 0 0 0 22.3291 0 0 0 0 0 0 0 0 A0A9Q1CMR3 A0A9Q1CMR3_HOLLE NLR family CARD domain-containing protein 4 HOLleu_06364 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) macroautophagy [GO:0016236]; signal transduction [GO:0007165] phagophore assembly site [GO:0000407] ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] 1 0.8 1.0076 -6.2493 VHRYIECSCCGEE 0 0 0 0 0 0 0 0 0 22.5492 0 0 20.5499 20.0189 20.0189 0 0 0 A0A9Q1CMR5 A0A9Q1CMR5_HOLLE Neural Wiskott-Aldrich syndrome protein HOLleu_06627 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin filament polymerization [GO:0030041] actin filament [GO:0005884]; nucleus [GO:0005634] actin binding [GO:0003779] 1 3.5 1.0113 -11.621 PSEDEDSFDEDEWDDDDD 21.2174 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CMR6 A0A9Q1CMR6_HOLLE Phospholipid scramblase HOLleu_00861 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] 1 5.8 1.0106 -5.5027 FCWCADCSDDCAYAIS 0 0 0 0 0 0 22.7096 23.303 23.303 0 0 0 0 0 0 0 0 0 A0A9Q1CMS1 A0A9Q1CMS1_HOLLE Uncharacterized protein HOLleu_00466 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.1 1.0169 -6.0779 KLTRLQQWTLRRYA 0 0 0 0 0 0 0 0 0 21.507 20.7889 20.7889 0 0 0 0 0 0 A0A9Q1CMU2 A0A9Q1CMU2_HOLLE Protein piccolo HOLleu_06604 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; intracellular protein transport [GO:0006886]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300] cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic membrane [GO:0042734] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] 2 1.1 0.99748 -35.172 DEDEEGDDEDEEYDNEGDA;VGGKRMPG 18.3581 20.7829 20.7829 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CMV8 A0A9Q1CMV8_HOLLE phosphoinositide 5-phosphatase (EC 3.1.3.36) HOLleu_00318 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphatidylinositol dephosphorylation [GO:0046856]; synaptic vesicle endocytosis [GO:0048488] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793] "nucleic acid binding [GO:0003676]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]" 1 0.9 1.0271 -23.631 TSMCFMCGHFA 16.542 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CMW7 A0A9Q1CMW7_HOLLE Inner nuclear membrane protein Man1 HOLleu_06325 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of BMP signaling pathway [GO:0030514]; nuclear envelope organization [GO:0006998] endomembrane system [GO:0012505]; membrane [GO:0016020]; nucleus [GO:0005634]; organelle envelope [GO:0031967] chromatin DNA binding [GO:0031490] 1 2.2 1.0104 -11.395 PRKTTPHSLNRSEAGSFFG 0 0 0 0 0 0 0 0 0 19.1034 0 0 0 0 0 0 0 0 A0A9Q1CMY0 A0A9Q1CMY0_HOLLE Crystal protein HOLleu_06676 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholinesterase activity [GO:0004104] 1 2.5 1.0168 -6.0779 WSFEEGWTEDFSMC 0 0 0 0 0 0 0 22.7409 22.7409 0 0 0 0 0 0 0 0 0 A0A9Q1CMY1 A0A9Q1CMY1_HOLLE Transcription initiation factor TFIID subunit 3 HOLleu_06750 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of transcription by RNA polymerase II [GO:0045944] transcription factor TFIID complex [GO:0005669] metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982] 1 0.8 0.98758 -0.068637 YKKKKFKK 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18.9034 20.6108 20.6108 A0A9Q1CN05 A0A9Q1CN05_HOLLE DNA-directed DNA polymerase HOLleu_00630 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.3 1.0113 -7.7234 DEPFESSCDFC;WHGCPDCF 21.0182 0 0 0 0 0 18.4946 18.4446 18.4446 0 0 0 0 0 0 0 0 0 A0A9Q1CN08 A0A9Q1CN08_HOLLE ATP-dependent DNA helicase (EC 3.6.4.12) HOLleu_01084 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678] 2 3.3 1.0114 -7.3197 NHCSDHTSTESTSDEFSEVDDN;VKRYSRRPKVLEKWCLAD 0 24.8681 24.8681 0 0 0 0 0 0 0 0 0 0 21.5282 21.5282 0 0 0 A0A9Q1CN43 A0A9Q1CN43_HOLLE Zinc finger protein 84 HOLleu_01169 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 0.9 1.0189 -23.723 GQAFKCHMC 19.9542 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CN45 A0A9Q1CN45_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_06466 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.9 1.0039 -23.777 DGWDDAAA 0 0 0 0 0 0 17.3203 0 0 20.062 0 0 0 0 0 0 0 0 A0A9Q1CN46 A0A9Q1CN46_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_06608 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] chitin binding [GO:0008061]; G protein-coupled receptor activity [GO:0004930] 2 3.1 1.0033 -26.366 CCSPYNWCG;RVPLVIHRG 0 0 0 0 0 0 0 0 0 20.7911 20.7639 20.7639 0 23.0706 23.0706 0 0 0 A0A9Q1CNA2 A0A9Q1CNA2_HOLLE "dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase (EC 2.4.1.256)" HOLleu_06995 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dolichol-linked oligosaccharide biosynthetic process [GO:0006488] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]" 2 5.6 1.0057 -6.3982 ILPFIIFRL;RFLKSLRGNGWLFLLLFAFML 0 0 0 0 0 0 0 0 0 0 0 0 23.0128 0 0 0 0 0 A0A9Q1CNB3 A0A9Q1CNB3_HOLLE C2H2-type domain-containing protein HOLleu_00238 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" 2 1.8 1.0027 -5.0477 DGNGDGHSPD;GELDDGAN 0 0 0 0 0 0 0 0 0 21.8676 21.3366 21.3366 0 0 0 0 0 0 A0A9Q1CNC4 A0A9Q1CNC4_HOLLE DnaJ-like subfamily C member 5-like HOLleu_00257 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of neuromuscular synaptic transmission [GO:1900073] membrane [GO:0016020]; type Is terminal bouton [GO:0061177] 4 19.4 0.9914 -1.0023 CFRITLTCCFFCTCYCFCFCCCLC;FCCCLCCFGCCGKCRKEREEDEDFE;FRITLTCCFFCTCYCFCFCCCLCC;RITLTCCFFCTCYCFCFCCCLCCF 21.5215 0 0 0 0 0 25.0521 0 0 21.116 19.2528 19.2528 25.1015 25.7538 25.7538 15.7719 0 17.54 A0A9Q1CNC7 A0A9Q1CNC7_HOLLE Dedicator of cytokinesis protein 4 HOLleu_06621 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] 1 0.5 1.0224 -23.675 ANDDMIRLFL 0 0 0 0 0 0 19.5505 19.2543 19.2543 0 0 0 0 0 0 0 0 0 A0A9Q1CNE6 A0A9Q1CNE6_HOLLE Uncharacterized protein HOLleu_06656 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.8 1.0161 -2.6427 TPAEFCPDP 0 24.1321 24.1321 0 0 0 0 0 0 23.853 0 0 0 0 0 0 0 0 A0A9Q1CNG1 A0A9Q1CNG1_HOLLE PHD-type domain-containing protein HOLleu_00787 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 5 1.0183 -21.924 YCKRCLKWYHESCFG 0 0 0 0 0 0 16.3525 16.7498 16.7498 0 0 0 0 0 0 0 0 0 A0A9Q1CNK9 A0A9Q1CNK9_HOLLE N-lysine methyltransferase KMT5A HOLleu_01568 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] methyltransferase activity [GO:0008168] 1 1.1 1.0106 -5.5027 QDIQEAADDGNSSNED 0 0 0 0 0 0 0 21.2818 21.2818 0 0 0 0 0 0 0 0 0 A0A9Q1CNM0 A0A9Q1CNM0_HOLLE Carbohydrate sulfotransferase (EC 2.8.2.-) HOLleu_00442 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate biosynthetic process [GO:0016051]; proteoglycan biosynthetic process [GO:0030166] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] 1 7.8 0.73077 -0.068637 AHNGLRLFRRLNNWQQKYALKNYRK 0 0 0 0 20.03 20.03 0 0 0 0 0 0 20.6569 20.7974 20.7974 0 0 0 A0A9Q1CNQ8 A0A9Q1CNQ8_HOLLE Pterin-binding domain-containing protein HOLleu_01203 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) pteridine-containing compound metabolic process [GO:0042558] 1 2.6 0.98773 -0.068637 RSQNGGGC 0 0 0 0 0 0 0 0 0 21.0117 0 0 0 0 0 0 0 0 A0A9Q1CNR5 A0A9Q1CNR5_HOLLE Endonuclease/exonuclease/phosphatase domain-containing protein HOLleu_01013 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) catalytic activity [GO:0003824] 2 36.1 0.99819 -33.319 ICSVNVRGLRDRHKRRKVF;RKVFLWLRQRKCDIH 19.5509 21.7216 21.7216 19.4307 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CNS7 A0A9Q1CNS7_HOLLE Uncharacterized protein HOLleu_01246 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.1 1.0043 -23.777 KMKLHLKK 0 0 0 0 18.2663 18.2663 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CNW2 A0A9Q1CNW2_HOLLE DNA-directed DNA polymerase HOLleu_01321 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 0.9878 -0.068637 YEMDTDSA 0 21.8706 21.8706 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CNY4 A0A9Q1CNY4_HOLLE Methyltransferase-like protein 27 HOLleu_01163 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] 1 4.6 1.022 -23.675 GDEECFCKYY 0 0 0 0 0 0 0 0 0 0 19.5817 19.5817 0 0 0 0 0 0 A0A9Q1CP11 A0A9Q1CP11_HOLLE Uncharacterized protein HOLleu_00178 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.9 1.0133 -5.7538 CMDPCMMATNKDDCV 0 0 0 0 0 0 0 0 0 23.8778 0 0 0 0 0 0 0 0 A0A9Q1CP25 A0A9Q1CP25_HOLLE THAP domain-containing protein 1 HOLleu_01253 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA binding [GO:0003677] 1 1.7 1.0131 -5.5027 HVVCEDHFTADCFVED 0 0 0 0 0 0 0 0 0 0 22.4808 22.4808 0 0 0 0 0 0 A0A9Q1CP34 A0A9Q1CP34_HOLLE Myb/SANT-like DNA-binding domain-containing protein HOLleu_00781 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.1 1.0172 -6.0118 PSCESPPARMET 0 21.3597 21.3597 0 0 0 0 0 0 21.9541 21.2073 21.2073 0 0 0 0 0 0 A0A9Q1CP41 A0A9Q1CP41_HOLLE Uncharacterized protein HOLleu_00800 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 20.6 1.0071 -6.0804 HYHECSTDMSDG;QVRQVVRR 0 0 0 0 0 0 0 0 0 22.6918 0 0 23.4077 0 0 0 0 0 A0A9Q1CP44 A0A9Q1CP44_HOLLE C2H2-type domain-containing protein HOLleu_00237 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] 1 1 1.0027 -23.777 QCKTGDES 0 0 0 0 0 0 0 21.4618 21.4618 0 0 0 0 0 0 0 0 0 A0A9Q1CP46 A0A9Q1CP46_HOLLE C2H2-type domain-containing protein HOLleu_01292 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694] chromatin insulator sequence binding [GO:0043035]; metal ion binding [GO:0046872] 1 4.1 1.0051 -23.777 KTRKGKTT 19.6071 21.3355 21.3355 0 18.4884 18.4884 0 0 0 0 0 0 0 18.586 18.586 0 0 0 A0A9Q1CP95 A0A9Q1CP95_HOLLE Uncharacterized protein HOLleu_00214 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.8 1.0057 -2.6427 NEPSIDDEQ 0 22.8643 22.8643 0 0 0 0 0 0 19.2182 0 0 0 0 0 0 0 0 A0A9Q1CP98 A0A9Q1CP98_HOLLE procollagen-proline 3-dioxygenase (EC 1.14.11.7) HOLleu_01400 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen metabolic process [GO:0032963] endoplasmic reticulum [GO:0005783] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797] 2 3 1.0008 -3.1668 DDDDDYEEEEEEE;EEEEEEEKDEEEEEKDEEEED 0 22.5977 22.5977 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CPD7 A0A9Q1CPD7_HOLLE Insulin-like growth factor-binding protein complex acid labile subunit HOLleu_02254 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615]; membrane [GO:0016020] 1 2.1 1.01 -5.3628 YLIILWRFKGKKKANGKKRSVID 0 0 0 0 0 0 0 0 0 0 19.4878 19.4878 0 0 0 0 0 0 A0A9Q1CPH9 A0A9Q1CPH9_HOLLE Uncharacterized protein HOLleu_01089 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.3 0.94149 -0.068637 VGVSKSSS 19.3681 0 0 0 0 0 0 0 0 21.4762 21.504 21.504 0 0 0 0 0 0 A0A9Q1CPP7 A0A9Q1CPP7_HOLLE Phospholipid scramblase HOLleu_00882 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] 2 6 1.0177 -16.888 FQCCSGCC;RPFQCCSGCCWCADCCD 21.0403 19.7986 19.7986 0 0 0 16.852 0 0 25.2125 24.8091 24.8091 18.5996 16.7344 16.7344 0 0 0 A0A9Q1CPP9 A0A9Q1CPP9_HOLLE Zinc finger CCHC domain-containing protein 3 HOLleu_01706 HOLleu_01707 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) activation of innate immune response [GO:0002218] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] 1 4 0.93651 -0.068637 SYDGGDDD 24.6299 24.7037 24.7037 0 0 0 0 0 0 21.9179 20.9613 20.9613 0 0 0 0 0 0 A0A9Q1CPT0 A0A9Q1CPT0_HOLLE Sushi domain-containing protein HOLleu_01784 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.3 0.99632 -4.7869 YFRRKSNTQYTVLLCWKT 0 0 0 0 0 0 0 0 0 0 23.6859 23.6859 0 0 0 0 0 0 A0A9Q1CPW0 A0A9Q1CPW0_HOLLE Regenerating islet-derived protein 3-alpha HOLleu_01398 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 7.2 0.98234 -0.30273 LWEEYEDNCFMM 23.1253 30.3877 30.3877 0 0 0 0 0 0 0 23.2697 23.2697 0 22.7976 22.7976 0 0 0 A0A9Q1CPX0 A0A9Q1CPX0_HOLLE Zinc transporter ZIP4 HOLleu_02651 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion import across plasma membrane [GO:0071578] membrane [GO:0016020] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] 1 1.3 1.019 -23.723 QCTSALTDH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18.2511 0 0 A0A9Q1CQ56 A0A9Q1CQ56_HOLLE THAP-type domain-containing protein HOLleu_01597 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] DNA binding [GO:0003677] 1 3.3 1.0177 -22.715 SYHCDCSKNCFCPG 20.4661 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CQ70 A0A9Q1CQ70_HOLLE Uncharacterized protein HOLleu_02075 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5.8 1.0028 -4.979 KPIRRTVKKH 0 28.7569 28.7569 0 20.5945 20.5945 22.9702 22.8524 22.9015 25.2488 26.674 26.674 18.7427 25.5688 25.5688 0 0 0 A0A9Q1CQA6 A0A9Q1CQA6_HOLLE NLR family CARD domain-containing protein 4 HOLleu_02407 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.3 1.0059 -23.777 WWPRGCDG 0 19.702 19.702 0 0 0 0 0 0 20.907 0 0 0 0 0 0 0 0 A0A9Q1CQC4 A0A9Q1CQC4_HOLLE Transposase domain-containing protein HOLleu_01370 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.9 0.91429 -0.068637 HVHGVKGP 21.4102 0 0 18.5182 0 0 0 0 0 0 0 0 0 18.4442 18.4442 0 0 17.5965 A0A9Q1CQI1 A0A9Q1CQI1_HOLLE Uncharacterized protein HOLleu_01868 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.3 1.0173 -21.924 TMYIHDGICMYGCTC 0 0 0 0 0 0 0 0 0 19.7429 0 0 0 0 0 0 0 0 A0A9Q1CQL1 A0A9Q1CQL1_HOLLE Thrombospondin-4 HOLleu_02629 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] 2 0.6 0.975 -0.13727 QNGYGDSC;YDGDGTVD 20.7621 22.3129 22.3129 0 0 0 0 0 0 22.3305 19.3933 19.3933 0 0 0 0 0 0 A0A9Q1CQR2 A0A9Q1CQR2_HOLLE Zinc finger MYM-type protein 1 HOLleu_02046 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein dimerization activity [GO:0046983] 1 1 0.90995 -0.068637 GATMAHCV 0 0 0 0 24.4695 24.4695 0 26.3663 26.3663 0 0 0 0 0 0 23.2674 23.6099 23.6099 A0A9Q1CQR6 A0A9Q1CQR6_HOLLE Jerky protein-like-like HOLleu_01779 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] DNA binding [GO:0003677] 1 1.7 1.0014 -4.979 CMFCDEMYVD 0 0 0 0 15.2652 0 0 0 0 0 0 0 0 22.9848 22.9848 0 0 0 A0A9Q1CQR8 A0A9Q1CQR8_HOLLE B-cell CLL/lymphoma 9 protein HOLleu_02483 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070]; positive regulation of transcription by RNA polymerase II [GO:0045944] beta-catenin-TCF complex [GO:1990907] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] 1 0.5 0.91038 -0.068637 VSMSGAPY 0 0 0 0 0 0 21.6813 21.5501 21.5501 0 0 0 0 0 0 0 0 0 A0A9Q1CQT4 A0A9Q1CQT4_HOLLE THAP-type domain-containing protein HOLleu_03441 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA binding [GO:0003677] 1 7 0.9061 -0.068637 NCAVNGCG 0 0 0 23.7123 23.183 23.183 0 0 0 0 19.3153 19.3153 0 22.7387 22.7387 20.6096 21.8537 22.8537 A0A9Q1CQV0 A0A9Q1CQV0_HOLLE CCR4-NOT transcription complex subunit 11 HOLleu_01455 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634] 1 2 1.0073 -2.6427 DPGSNMVDW 0 0 0 0 0 0 0 0 0 23.6461 23.1461 23.1461 16.9366 0 0 0 0 0 A0A9Q1CQY4 A0A9Q1CQY4_HOLLE Uncharacterized protein HOLleu_02614 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.9 1.0209 -23.723 PKIPRGKPK 25.6702 0 0 0 0 0 25.5427 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CR15 A0A9Q1CR15_HOLLE Uncharacterized protein HOLleu_02960 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.5 0.90187 -0.068637 KRRLSVGG 0 0 0 0 0 0 22.6845 0 0 0 0 0 19.4829 22.0831 22.0831 16.3499 0 0 A0A9Q1CR68 A0A9Q1CR68_HOLLE Neurogenic locus notch-like protein 1 HOLleu_01570 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 1 2 1.0057 -2.6427 TDGYTGFIC 0 23.635 23.635 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CRB8 A0A9Q1CRB8_HOLLE Uncharacterized protein HOLleu_02461 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677] 1 2.3 1.0141 -2.2078 MDEDDDQTSSSGDSSDSSESEYE 0 21.5674 21.5674 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CRH3 A0A9Q1CRH3_HOLLE DNA-directed DNA polymerase (EC 2.7.7.7) HOLleu_02239 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA replication [GO:0006260] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166] 1 1.1 1.0137 -5.5027 EDPESENGNEMDSLVS 0 0 0 0 0 0 21.2141 22.3458 22.3458 0 0 0 0 0 0 0 0 0 A0A9Q1CRI9 A0A9Q1CRI9_HOLLE Uncharacterized protein HOLleu_03108 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 1.0059 -23.777 HDGDYCAA 0 0 0 0 0 0 0 0 0 0 0 0 19.2958 0 0 0 0 0 A0A9Q1CRJ5 A0A9Q1CRJ5_HOLLE B box-type domain-containing protein HOLleu_01833 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 2 0.6 0.99857 -47.554 FIKIKHHK;GSASPTYE 0 20.5286 20.5286 0 0 0 0 0 0 0 0 0 0 0 0 19.3109 0 0 A0A9Q1CRL2 A0A9Q1CRL2_HOLLE Scavenger receptor cysteine-rich domain superfamily protein HOLleu_04106 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.6 0.90233 -0.068637 KRCCCCCK 0 18.2098 18.2098 0 0 0 0 0 0 21.0507 0 0 0 0 0 0 0 0 A0A9Q1CRM5 A0A9Q1CRM5_HOLLE Uncharacterized protein HOLleu_03448 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.2 1.01 -6.0779 SGETVRQKRKKIEC 0 20.9666 20.9666 0 0 0 16.8581 0 0 0 0 0 0 17.5505 17.5505 0 0 0 A0A9Q1CRR0 A0A9Q1CRR0_HOLLE Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein HOLleu_02125 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.5 1.0281 -23.631 CENQNSSSAYG 0 0 0 0 0 0 20.2072 20.2646 20.2646 0 0 0 0 19.8342 19.8342 0 0 0 A0A9Q1CRR2 A0A9Q1CRR2_HOLLE Uncharacterized protein HOLleu_03276 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.7 1.0233 -23.675 SSEGDDGHTT 17.8254 0 0 0 0 0 0 0 0 18.8145 0 0 0 0 0 0 0 0 A0A9Q1CRS3 A0A9Q1CRS3_HOLLE LRRNT domain-containing protein HOLleu_02143 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 13.4 1.0162 -5.5496 TSACGDGGICH 0 20.6248 20.6248 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CRS4 A0A9Q1CRS4_HOLLE Uncharacterized protein HOLleu_02534 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 4.1 0.97507 -0.13727 EGPKLIMR;WGMHSHEH 0 23.21 23.21 0 0 0 0 0 0 23.6461 0 0 0 21.4491 21.4491 0 0 0 A0A9Q1CRY8 A0A9Q1CRY8_HOLLE Reverse transcriptase domain-containing protein HOLleu_02917 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2 0.89815 -0.068637 NCDDYDTE 20.3051 21.4053 21.4053 0 0 0 0 0 0 20.8762 20.433 20.433 0 0 0 0 0 0 A0A9Q1CSA5 A0A9Q1CSA5_HOLLE C2H2-type domain-containing protein HOLleu_02351 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872] 1 4.8 1.0174 -23.723 HVDRNYSCD 18.0926 0 0 0 0 0 0 0 0 0 17.99 17.99 0 0 0 0 0 0 A0A9Q1CSF9 A0A9Q1CSF9_HOLLE P2X purinoceptor 7 HOLleu_03343 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.7 1.0128 -5.7538 NDVNWCQCTNCAGMP 0 21.6144 21.6144 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CSI6 A0A9Q1CSI6_HOLLE Kinesin-like protein KIF21A HOLleu_03027 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] microtubule associated complex [GO:0005875] microtubule motor activity [GO:0003777] 2 5.1 1.0168 -22.322 QIPPPRKRER;RTKEKAEKIKKEFEI 0 0 0 0 0 0 0 0 0 21.3851 0 0 0 0 0 0 0 0 A0A9Q1CSN5 A0A9Q1CSN5_HOLLE MAM and LDL-receptor class A domain-containing protein 2 HOLleu_03957 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 4 0.9 1.0209 -18.857 AWTNDREDDDWD;CQDKTDEAMC;GMCAWTNDREDDDWDWE;GNCEYNDGD 20.4453 23.5913 23.5913 0 0 0 22.1619 15.944 15.944 21.9263 25.231 25.231 17.6013 17.742 17.742 0 0 0 A0A9Q1CSP9 A0A9Q1CSP9_HOLLE Fibrinogen-like protein A HOLleu_03978 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.1 1.0027 -2.5328 YENCTCQKSCGNPHDCLDTCDN 0 0 0 0 0 0 23.8714 23.7028 23.7028 0 0 0 0 0 0 18.1061 0 18.6497 A0A9Q1CSS1 A0A9Q1CSS1_HOLLE Zinc transporter ZIP12 HOLleu_04017 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion import across plasma membrane [GO:0071578] membrane [GO:0016020] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] 1 2.4 1.0196 -23.723 DHSDHSGHD 18.2625 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CST0 A0A9Q1CST0_HOLLE Uncharacterized protein HOLleu_03261 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.4 0.92698 -0.068637 DLCEGEGP 0 0 0 0 0 0 0 21.4801 21.4801 0 0 0 0 0 0 0 0 0 A0A9Q1CST8 A0A9Q1CST8_HOLLE Uncharacterized protein HOLleu_03410 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 19.1 0.96809 -0.17167 WIGPGLILKRVTDVIYRVKMGPKRR 0 0 0 0 0 0 0 0 0 21.9539 21.563 21.563 0 0 0 0 0 0 A0A9Q1CSW0 A0A9Q1CSW0_HOLLE Crinkler (CRN) family protein HOLleu_03473 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 1.0073 -2.6427 FFECTCMCD 21.0317 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CSW5 A0A9Q1CSW5_HOLLE Sushi domain-containing protein HOLleu_04393 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.4 1.0229 -23.675 CQYTCDEGYQ 0 0 0 0 0 0 0 0 0 21.2223 0 0 0 0 0 0 0 0 A0A9Q1CSY2 A0A9Q1CSY2_HOLLE Uncharacterized protein HOLleu_03726 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.6 0.98387 -0.20876 TLRIISTGLHQEKERQEGTPPHTT 20.2162 0 0 0 0 0 0 0 0 0 0 0 0 17.3392 17.3392 0 0 0 A0A9Q1CSY3 A0A9Q1CSY3_HOLLE Rho GTPase-activating protein 39 HOLleu_04189 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] GTPase activator activity [GO:0005096] 1 0.9 1.0227 -5.5496 FYDRCIEHCED 0 0 0 0 0 0 0 0 0 23.0047 22.3255 22.3255 0 0 0 0 0 0 A0A9Q1CSY5 A0A9Q1CSY5_HOLLE ATP-dependent DNA helicase (EC 3.6.4.12) HOLleu_04436 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] 1 0.9 1.0169 -6.0779 FLDMKCDTEFQCAD 0 22.0563 22.0563 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CSZ8 A0A9Q1CSZ8_HOLLE NACHT domain-containing protein HOLleu_03562 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0169 -23.723 IQDKYIRWI 0 19.454 19.454 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CSZ9 A0A9Q1CSZ9_HOLLE Fibrinogen C domain-containing protein 1-A HOLleu_03758 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5 1.0091 -10.482 CSYYDVCTEC;YSYSYCHYFETRSSCN 17.0807 22.4578 22.4578 0 15.7475 0 0 0 0 25.2658 22.1728 22.1728 0 18.0336 18.0336 0 0 0 A0A9Q1CT13 A0A9Q1CT13_HOLLE Zinc finger MYM-type protein 1 HOLleu_03090 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.3 0.89862 -0.068637 RLPRLRKP 0 22.4429 22.4429 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CT55 A0A9Q1CT55_HOLLE Reverse transcriptase domain-containing protein HOLleu_03685 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.2 1.0156 -5.5496 LPKIHKLTSLI 0 0 0 20.6654 20.94 20.94 0 22.8349 22.8349 24.3549 0 0 0 21.7667 21.7667 20.4082 0 20.6826 A0A9Q1CT61 A0A9Q1CT61_HOLLE Fibrinogen C domain-containing protein 1 HOLleu_04349 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 7 0.99928 -35.958 FAFMCICCFGKSSA;QCYCNDGYNGDGE;YGNCTCMDKCE 23.2344 17.5347 17.5347 0 0 0 0 0 0 17.7075 22.1772 22.1772 18.6706 15.8958 15.8958 0 0 0 A0A9Q1CT88 A0A9Q1CT88_HOLLE MAM and LDL-receptor class A domain-containing protein 2 HOLleu_03956 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 8 3.8 0.99892 -38.045 ACDYNDDCGDFSEE;CLEFYYHMFGDDS;CPGAGFTG;GDQEYCFSFW;NQACDYNDDCGDFSEEDDE;WRCGDGGC;WTALKIDDETG;YMYVDQSQ 0 23.286 23.286 0 0 0 0 0 0 0 21.0158 21.0158 17.5434 17.1986 17.1986 0 0 0 A0A9Q1CTB4 A0A9Q1CTB4_HOLLE MAM and LDL-receptor class A domain-containing protein 2 HOLleu_03682 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 5 1.3 0.99892 -38.36 DDESMCGSCDFDNSLCGMES;GWQQDRDDDEDW;IQGQDIDHLGTYLLV;LDGTCPDEDFCHFELDFCDW;TGPAMDHT 20.732 0 0 0 17.3318 17.3318 23.6481 0 0 20.9567 0 0 0 21.9724 21.9724 17.0997 0 0 A0A9Q1CTC1 A0A9Q1CTC1_HOLLE Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A HOLleu_04472 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phagocytosis [GO:0006909] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone H4R3 demethylase activity [GO:0033749]; P-TEFb complex binding [GO:0106140] 2 5 1.0051 -8.5446 SSSDGNSSCSTC;STSSSDGNSSCSTCAEYSCDSG 0 0 0 0 0 0 22.9698 23.7994 23.7994 0 0 0 0 0 0 0 0 0 A0A9Q1CTD3 A0A9Q1CTD3_HOLLE Zinc transporter ZIP12 HOLleu_04480 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion import across plasma membrane [GO:0071578] membrane [GO:0016020] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] 1 1.1 0.11111 -0.068637 GGQDSGHG 0 26.7737 26.7737 0 0 0 0 0 0 26.6959 26.334 26.334 21.9325 0 0 0 0 0 A0A9Q1CTK7 A0A9Q1CTK7_HOLLE Double-stranded RNA-specific editase 1 HOLleu_04215 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; nucleolus [GO:0005730] double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251] 1 4 0.90411 -0.068637 KMELFTAF 0 0 0 25.219 0 0 0 0 0 0 0 0 0 0 0 24.6242 22.3563 22.3563 A0A9Q1CTN3 A0A9Q1CTN3_HOLLE Uncharacterized protein HOLleu_04279 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] 1 2 0.9 -0.068637 GSGEDCNG 24.804 24.3705 24.3705 0 0 0 0 0 0 24.8489 25.1536 25.1536 0 0 0 0 0 0 A0A9Q1CTR3 A0A9Q1CTR3_HOLLE Caveolin HOLleu_04340 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) caveola assembly [GO:0070836] caveola [GO:0005901]; Golgi membrane [GO:0000139] molecular adaptor activity [GO:0060090] 1 12.7 0.9916 -0.31124 MGTGCISCEGGEDESDGEMEDFFE 0 0 0 0 0 0 0 0 0 0 0 0 0 22.0292 22.0292 0 0 0 A0A9Q1CTR8 A0A9Q1CTR8_HOLLE FK506-binding protein 4 HOLleu_04200 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 3.5 1.0101 -2.2424 GNAGSGHD;SDHDHCGP 22.0912 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CTS4 A0A9Q1CTS4_HOLLE Gypsy retrotransposon integrase-like protein 1 HOLleu_04370 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] 1 1.2 1.0039 -23.777 PKLHCPWK 0 0 0 0 0 0 0 0 0 0 0 0 20.8017 0 0 0 0 0 A0A9Q1CTV1 A0A9Q1CTV1_HOLLE Tyrosine kinase receptor Cad96Ca HOLleu_04132 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] 1 2.8 1.0067 -23.777 PLKLRHKN 0 0 0 0 0 0 0 17.6015 17.6015 0 0 0 0 0 0 0 0 0 A0A9Q1CTV8 A0A9Q1CTV8_HOLLE Integrase catalytic domain-containing protein HOLleu_03826 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] 3 2 1.004 -2.7799 AIAVCLHLK;DYCMFMQD;YSRKRWRRVQYMTNVFWSRWRKEYL 23.414 25.7128 25.7128 0 0 0 0 18.7119 18.7119 19.4577 0 0 0 0 0 0 0 0 A0A9Q1CTX0 A0A9Q1CTX0_HOLLE BRCT domain-containing protein HOLleu_03851 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 0.90045 -0.068637 TRHGGGYR 0 0 0 0 0 0 0 0 0 21.5067 21.7741 21.7741 0 0 0 0 0 0 A0A9Q1CTY4 A0A9Q1CTY4_HOLLE A to I editase domain-containing protein HOLleu_04214 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; nucleolus [GO:0005730] double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251] 1 11.9 1.0292 -23.442 LKPLTEHDQFAE 20.6301 23.5962 23.5962 0 0 0 18.0061 0 0 0 0 0 18.8011 18.8686 18.8686 0 0 0 A0A9Q1CU07 A0A9Q1CU07_HOLLE Ig-like domain-containing protein HOLleu_04435 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.9 1.0257 -23.723 PCDFMTFLE 0 0 0 0 0 0 0 0 0 0 20.0532 20.0532 0 16.7554 16.7554 0 0 0 A0A9Q1CU27 A0A9Q1CU27_HOLLE BRCT domain-containing protein HOLleu_03862 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.5 0.8964 -0.068637 MKKKVFKK 28.261 30.3415 30.3415 16.6776 0 0 28.9319 25.7412 27.2758 29.534 29.0525 29.0525 25.4275 25.6781 25.6781 0 0 17.118 A0A9Q1CU48 A0A9Q1CU48_HOLLE Uncharacterized protein HOLleu_04562 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] 1 2.1 0.89238 -0.068637 PHVAGGAA 0 0 0 20.5125 20.0185 20.0185 19.6367 20.1932 20.1932 0 0 0 0 20.9267 20.9267 18.2649 0 20.0084 A0A9Q1CU77 A0A9Q1CU77_HOLLE C2H2-type domain-containing protein HOLleu_04201 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of gene expression [GO:0010468] nucleus [GO:0005634] 1 1.6 0.88839 -0.068637 DDNGDHIG 0 22.2455 22.2455 0 0 0 18.5304 0 0 22.0287 0 0 20.09 19.7474 19.7474 0 0 0 A0A9Q1CU81 A0A9Q1CU81_HOLLE Zinc finger protein 84 HOLleu_04061 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of gene expression [GO:0010468] nucleus [GO:0005634] 1 3.7 1.0172 -5.6907 FCDKCFIQERQCKRHEMTHTGE 0 0 0 0 0 0 0 0 0 21.1504 0 0 0 0 0 0 0 0 A0A9Q1CUA7 A0A9Q1CUA7_HOLLE Transposase HOLleu_04318 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 12.5 1.0101 -10.943 AIAVFIGISLRKKKRKAKEK 0 19.3726 19.3726 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CUB8 A0A9Q1CUB8_HOLLE Protein NLRC5 HOLleu_04653 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.6 0.98398 -0.20876 SPLKEVDILIFLRLRQLIDVSSIF 0 0 0 19.0793 0 0 19.9113 0 0 21.7737 0 0 0 19.8773 19.8773 17.8697 0 0 A0A9Q1CUI8 A0A9Q1CUI8_HOLLE Secreted frizzled-related protein 3 HOLleu_04473 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; non-canonical Wnt signaling pathway [GO:0035567] cytoplasm [GO:0005737]; extracellular space [GO:0005615] Wnt-protein binding [GO:0017147] 1 2.7 1.004 -2.6427 DAGSMCEPI 0 22.4735 22.4735 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CUJ3 A0A9Q1CUJ3_HOLLE "NACHT, LRR and PYD domains-containing protein 10" HOLleu_04639 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 3.5 1.0117 -12.308 KIFSRFRKS;LAVILTILVIVACGIIARKI 22.5755 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1CUN1 A0A9Q1CUN1_HOLLE Butyrophilin subfamily 1 member A1 HOLleu_04616 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.7 0.88444 -0.068637 WCNCIETS 23.6599 0 0 0 0 0 0 0 0 0 23.7561 23.7561 0 0 0 0 0 0 A0A9Q1CUP8 A0A9Q1CUP8_HOLLE Zinc finger protein 84 HOLleu_04678 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 3.8 0.99356 -0.31124 VHTDENPHNCEFCEMSFVEMQEGD 0 0 0 0 0 0 0 22.657 22.657 0 0 0 0 0 0 0 0 0 A0A9Q1GVE7 A0A9Q1GVE7_HOLLE Cysteine and histidine-rich domain-containing protein 1 HOLleu_32483 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 4.4 1.0147 -6.0779 FSEEDDGPESCIHH 0 22.7118 22.7118 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1GVM8 A0A9Q1GVM8_HOLLE Arginine/serine-rich protein PNISR HOLleu_32667 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nuclear speck [GO:0016607]; presynaptic active zone [GO:0048786] RNA binding [GO:0003723] 1 1.9 1.0061 -5.2234 YNEEHSYQEGQYYEGNN 0 0 0 0 0 0 0 0 0 22.2125 0 0 0 0 0 0 0 0 A0A9Q1GWR5 A0A9Q1GWR5_HOLLE Neurochondrin HOLleu_30365 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) neuron projection development [GO:0031175]; regulation of neuronal synaptic plasticity [GO:0048168] dendrite [GO:0030425] 1 1.5 1.0257 -23.631 APEDCDEHMFH 0 19.3518 19.3518 0 0 0 0 0 0 18.0012 0 0 0 0 0 0 0 0 A0A9Q1GX39 A0A9Q1GX39_HOLLE Protein FAM47E HOLleu_30627 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein localization to chromatin [GO:0071168]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785] 1 2.4 1.0252 -23.631 NMYSDDEDDME 0 19.6644 19.6644 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1GX56 A0A9Q1GX56_HOLLE Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein HOLleu_30659 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) synaptic vesicle endocytosis [GO:0048488] membrane [GO:0016020] 1 0.4 1.0126 -10.943 EEMDEDFQQQEPSSDEDEEE 0 0 0 0 0 0 0 0 0 20.0414 0 0 0 0 0 0 0 0 A0A9Q1GXT2 A0A9Q1GXT2_HOLLE oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14) HOLleu_31136 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid biosynthetic process [GO:0006633]; toxin biosynthetic process [GO:0009403] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312] 2 0.6 1.0045 -25.951 EDAGMPPP;KVQGNTSN 0 0 0 0 0 0 0 0 0 0 0 0 16.6051 0 0 0 0 0 A0A9Q1GXU1 A0A9Q1GXU1_HOLLE Breast cancer type 2 susceptibility protein-like HOLleu_31161 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair via homologous recombination [GO:0000724]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] 1 0.3 1 -1.3651 ARIFKKRVI 0 0 0 20.9996 20.595 20.595 0 21.5756 21.5756 0 0 0 0 0 0 0 21.8264 21.8264 A0A9Q1GXZ6 A0A9Q1GXZ6_HOLLE Protein ENL HOLleu_28174 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of DNA-templated transcription [GO:0045893] transcription elongation factor complex [GO:0008023] chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577] 1 1.3 0.88496 -0.068637 SSSSDSDY 23.5702 22.1554 22.1554 0 15.7189 0 0 0 0 0 0 0 17.0424 17.6884 17.6884 0 0 0 A0A9Q1GY28 A0A9Q1GY28_HOLLE Rho GTPase-activating protein 20 HOLleu_32593 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] 1 1.2 1.0031 -4.125 KGDSFDSGMAADEVANMDFD 0 0 0 0 0 0 23.9514 23.0245 23.0245 0 0 0 0 0 0 0 0 0 A0A9Q1GY42 A0A9Q1GY42_HOLLE Neuroblastoma-amplified sequence HOLleu_28284 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" Dsl1/NZR complex [GO:0070939] SNARE binding [GO:0000149] 1 0.5 1.0267 -23.631 PRRGDSVGSGP 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14.963 14.963 A0A9Q1GY56 A0A9Q1GY56_HOLLE DNA mismatch repair protein Msh2 (MutS protein homolog 2) HOLleu_32647 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mismatch repair [GO:0006298]; mitotic recombination [GO:0006312] MutSalpha complex [GO:0032301] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] 1 2.4 1.0209 -5.6907 LESNNMLGFFFRVTRKEEKVLR 0 23.4865 23.4865 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1GY86 A0A9Q1GY86_HOLLE Organic cation transporter protein HOLleu_32705 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 1 2.2 1.0079 -6.2493 VEEWSQSVDDCYV 0 0 0 0 0 0 23.1885 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1GY99 A0A9Q1GY99_HOLLE Epoxide hydrolase 4 HOLleu_28435 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] epoxide hydrolase activity [GO:0004301] 1 2.4 0.88546 -0.068637 WGGMICWE 20.1672 21.6379 21.6379 0 0 0 0 0 0 0 22.1952 22.1952 16.9703 17.0422 17.0422 0 0 0 A0A9Q1GYA8 A0A9Q1GYA8_HOLLE Protein arginine N-methyltransferase 9 HOLleu_30081 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "protein-arginine N-methyltransferase activity [GO:0016274]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" 1 0.9 1.012 -23.777 EENACHMM 0 0 0 0 0 0 18.3818 22.7409 22.7409 0 0 0 0 0 0 0 0 0 A0A9Q1GYD0 A0A9Q1GYD0_HOLLE Fibropellin-1 HOLleu_28507 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 1.4 1.0054 -2.5328 CDSAQDRCSPNPCFNGGNCFNT 0 0 0 0 0 0 0 23.5737 23.5737 0 0 0 0 0 0 0 0 0 A0A9Q1GYE5 A0A9Q1GYE5_HOLLE Uncharacterized protein HOLleu_30158 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 16.7 1.0151 -5.5027 DDFGDGHGECWSGWVS 25.4376 0 0 0 0 0 0 0 0 0 27.2772 27.2772 0 0 0 0 0 0 A0A9Q1GYG9 A0A9Q1GYG9_HOLLE E3 ubiquitin-protein ligase TRIM33 HOLleu_28592 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 1.3 1.0182 -23.723 YTKEICSIK 17.7662 0 0 0 0 0 0 16.1374 16.1374 18.5228 16.6176 16.6176 0 0 0 0 0 0 A0A9Q1GYR2 A0A9Q1GYR2_HOLLE Small RNA 2'-O-methyltransferase (EC 2.1.1.386) HOLleu_28794 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) piRNA processing [GO:0034587]; RNA methylation [GO:0001510]; siRNA processing [GO:0030422] cytoplasm [GO:0005737]; nucleus [GO:0005634] O-methyltransferase activity [GO:0008171]; RNA methyltransferase activity [GO:0008173] 1 3.3 1.0021 -6.2493 ETEESSSESDEED 0 0 0 0 0 0 22.2013 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1GYU4 A0A9Q1GYU4_HOLLE Ufm1-specific protease 2 HOLleu_30448 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] 1 1.9 1.0141 -6.0118 SDDFHEACENAF 0 0 0 0 0 0 0 21.8929 21.8929 0 0 0 0 0 0 0 0 0 A0A9Q1GYU7 A0A9Q1GYU7_HOLLE "Dynein heavy chain 8, axonemal" HOLleu_32428 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule-based movement [GO:0007018] axonemal dynein complex [GO:0005858]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] 2 0.5 0.99636 -29.643 EVEFHEKDYDR;SEESQDEEDESD 0 18.8632 18.8632 0 0 0 0 0 0 28.0761 0 0 0 0 0 0 0 0 A0A9Q1GYU8 A0A9Q1GYU8_HOLLE Rab protein geranylgeranyltransferase component A 1 HOLleu_29943 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular protein transport [GO:0006886]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968] GDP-dissociation inhibitor activity [GO:0005092] 1 2.5 1.0116 -23.777 DEGGDDSP 19.204 0 0 0 18.9493 0 0 0 0 23.2656 0 0 18.2991 17.9302 17.9302 0 0 0 A0A9Q1GYX8 A0A9Q1GYX8_HOLLE Lysyl oxidase-like 3 HOLleu_30504 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] 1 0.5 1.0097 -2.6427 MQSGCYDNN 0 0 0 0 0 0 0 0 0 23.2082 22.8269 22.8269 0 0 0 0 0 0 A0A9Q1GYY8 A0A9Q1GYY8_HOLLE Uncharacterized protein HOLleu_30025 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 0.91827 -0.068637 FGGRGKKT 0 28.6973 28.6973 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1GZ03 A0A9Q1GZ03_HOLLE Uncharacterized protein HOLleu_28992 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phagocytosis [GO:0006909] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739] 1 4.8 1.0279 -23.027 PRKALDSASSRTS 0 22.3627 22.3627 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1GZ21 A0A9Q1GZ21_HOLLE Uncharacterized protein HOLleu_30572 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.9 1.0231 -5.5496 DGDAFDWCAGD 19.7011 22.2852 22.2852 0 0 0 0 0 0 0 20.9496 20.9496 0 0 0 0 0 0 A0A9Q1GZA0 A0A9Q1GZA0_HOLLE C-type mannose receptor 2 HOLleu_30229 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] signaling receptor activity [GO:0038023] 1 1.2 0.88158 -0.068637 GPMCPHGG 0 0 0 0 0 0 0 0 0 0 0 0 0 22.4965 22.4965 0 0 0 A0A9Q1GZC2 A0A9Q1GZC2_HOLLE Uncharacterized protein HOLleu_29232 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0224 -23.675 FYFQHSTDEE 0 0 0 0 0 0 0 0 0 0 0 0 17.6171 0 0 0 0 0 A0A9Q1GZG1 A0A9Q1GZG1_HOLLE DNA repair protein RAD50 HOLleu_30836 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004] condensed nuclear chromosome [GO:0000794]; Mre11 complex [GO:0030870] ATP hydrolysis activity [GO:0016887]; double-stranded telomeric DNA binding [GO:0003691]; G-quadruplex DNA binding [GO:0051880]; metal ion binding [GO:0046872]; single-stranded telomeric DNA binding [GO:0043047] 1 1.7 1.0248 -23.723 EELNHMEDN 0 0 0 0 0 0 19.1974 18.7452 18.7452 19.7751 0 0 18.5053 18.7928 18.7928 0 0 0 A0A9Q1GZS2 A0A9Q1GZS2_HOLLE Protein sprouty-like 2 HOLleu_30555 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ development [GO:0048513]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Ras protein signal transduction [GO:0046580] cytosol [GO:0005829]; membrane [GO:0016020] 1 3.8 1.0029 -4.979 YHCAEDTEDD 0 24.4993 24.4993 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H022 A0A9Q1H022_HOLLE Transmembrane and coiled-coil domain-containing protein 3 HOLleu_26526 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] potassium:proton antiporter activity [GO:0015386] 1 2.7 1 -4.564 NLLQTLIQLVGALGFVILL 0 0 0 0 0 0 0 0 0 22.656 0 0 0 0 0 0 0 0 A0A9Q1H040 A0A9Q1H040_HOLLE T-complex protein 1 subunit theta (CCT-theta) HOLleu_32616 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] 1 1.5 1.012 -23.777 VRVAKILG 19.8905 0 0 14.4775 0 0 0 0 0 18.8214 0 0 0 0 0 0 0 0 A0A9Q1H0C6 A0A9Q1H0C6_HOLLE Fatty acid synthase (EC 1.1.1.100) (EC 1.3.1.39) (EC 2.3.1.41) (EC 2.3.1.85) (EC 3.1.2.14) HOLleu_26823 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid biosynthetic process [GO:0006633] cytoplasm [GO:0005737] fatty acid synthase activity [GO:0004312]; hydrolase activity [GO:0016787]; oxidoreductase activity [GO:0016491] 1 0.5 1.0043 -6.2493 PKLTAASNLDQAT 0 24.2411 24.2411 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H0E1 A0A9Q1H0E1_HOLLE Teneurin-2 HOLleu_30368 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; motor neuron axon guidance [GO:0008045] neuron projection [GO:0043005]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] 1 0.6 1.0067 -5.2234 WSCPNDCSGNGFCNKGQ 21.5987 0 0 0 0 0 0 0 0 0 0 0 0 17.7733 17.7733 0 0 0 A0A9Q1H0F8 A0A9Q1H0F8_HOLLE Little elongation complex subunit 1 HOLleu_30412 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 0.6 1.0111 -2.2424 LGGKRKKT;VSVSGVFV 23.2774 25.0977 25.0977 0 0 0 24.0877 0 0 25.8105 25.2845 25.2845 23.097 23.3798 23.3798 0 0 0 A0A9Q1H0I5 A0A9Q1H0I5_HOLLE Complement C3 HOLleu_29792 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866] 1 0.5 1.0116 -23.777 LLVFKKLF 0 0 0 0 0 0 0 0 0 22.7832 0 0 0 0 0 0 0 0 A0A9Q1H0J1 A0A9Q1H0J1_HOLLE Ig-like domain-containing protein HOLleu_27038 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; membrane [GO:0016020] 1 3.4 1.0164 -6.0779 NCHQEYYHSAEQGD 22.8845 0 0 0 0 0 0 0 0 0 22.5003 22.5003 0 0 0 0 0 0 A0A9Q1H0J5 A0A9Q1H0J5_HOLLE Zinc finger MYM-type protein 1 HOLleu_30505 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.5 0.91083 -0.068637 RDSKLDEIRKETKNEHGGIRTLCPT 19.9225 22.7062 22.7062 18.4218 18.9773 18.9773 20.7788 20.6481 20.6481 22.1154 21.3234 21.3234 18.8743 18.5965 18.5965 17.0651 0 0 A0A9Q1H0K5 A0A9Q1H0K5_HOLLE Uncharacterized protein HOLleu_29848 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1 1.0198 -5.5713 GDFKNEDEDEDTSSGD;QGDVANYN 21.2048 23.2164 23.2164 0 0 0 0 0 0 0 0 0 18.8154 19.0162 19.0162 0 22.6488 22.6488 A0A9Q1H0Q7 A0A9Q1H0Q7_HOLLE G-protein coupled receptor 54 HOLleu_30009 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) neuropeptide signaling pathway [GO:0007218] membrane [GO:0016020] G protein-coupled peptide receptor activity [GO:0008528] 1 2.4 1.0169 -2.6427 RWKAVVLLT 0 0 0 0 0 0 0 0 0 0 22.4513 22.4513 0 0 0 0 0 0 A0A9Q1H0S5 A0A9Q1H0S5_HOLLE Sodium/calcium exchanger 2 HOLleu_28778 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion import across plasma membrane [GO:0098703]; cell communication [GO:0007154] axon [GO:0030424]; postsynapse [GO:0098794]; sarcolemma [GO:0042383] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] 1 5.3 0.9542 -0.17167 IILLILRRRVLGGELGGATIPKFGS 0 0 0 0 0 0 0 0 0 0 22.2922 22.2922 0 0 0 0 0 0 A0A9Q1H0T1 A0A9Q1H0T1_HOLLE Myogenesis-regulating glycosidase HOLleu_28797 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" 1 1.2 0.94737 -0.068637 IGGDENAD 20.5916 21.869 21.869 0 0 0 0 0 0 22.1795 21.6499 21.6499 17.2542 0 0 0 0 0 A0A9Q1H0T8 A0A9Q1H0T8_HOLLE Fucosyltransferase (EC 2.4.1.-) HOLleu_27405 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fucosylation [GO:0036065]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] alpha-(1->3)-fucosyltransferase activity [GO:0046920] 1 2.7 1.0186 -23.723 YNWSFTYHS 0 0 0 16.558 17.2283 17.8209 16.4951 0 0 17.0474 0 0 16.8387 0 0 0 0 0 A0A9Q1H0U7 A0A9Q1H0U7_HOLLE RBR-type E3 ubiquitin transferase (EC 2.3.2.31) HOLleu_30126 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 2 4.5 1.0056 -24.08 CNKMTCSRCFCNFC;TSTFTCGIC 0 0 0 0 0 0 0 0 0 22.5413 0 0 0 0 0 0 0 0 A0A9Q1H0V0 A0A9Q1H0V0_HOLLE Sorbitol dehydrogenase (Polyol dehydrogenase) HOLleu_28852 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sorbitol catabolic process [GO:0006062] L-iditol 2-dehydrogenase activity [GO:0003939]; zinc ion binding [GO:0008270] 1 2.3 0.9375 -0.068637 YCHAADFC 0 24.3114 24.3114 0 0 0 0 21.6997 21.7128 24.2582 0 0 17.5736 0 0 0 0 0 A0A9Q1H0V8 A0A9Q1H0V8_HOLLE Echinoidin HOLleu_27475 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 5.5 1.0174 -2.6427 LNTRDLDFV 0 0 0 0 0 0 0 0 0 22.6882 0 0 0 0 0 0 0 0 A0A9Q1H0X4 A0A9Q1H0X4_HOLLE Zeta-sarcoglycan HOLleu_30896 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cardiac muscle tissue development [GO:0048738]; heart contraction [GO:0060047] sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] 1 2.7 0.7 -0.068637 VTNGSSSS 0 0 0 0 0 0 0 0 0 21.9372 21.2657 21.2657 0 0 0 0 0 0 A0A9Q1H0Y8 A0A9Q1H0Y8_HOLLE Sushi repeat-containing protein SRPX2 HOLleu_30234 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023] 1 2.9 1.0043 -6.2493 SMPYGSICTLGCY 0 0 0 0 0 0 0 0 0 21.7083 24.7987 24.7987 0 0 0 0 0 0 A0A9Q1H112 A0A9Q1H112_HOLLE Uncharacterized protein HOLleu_27703 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.8 1.0211 -5.5496 HGGGGGGGGGG 0 0 0 0 0 0 0 0 0 0 0 0 20.4978 20.6774 20.6774 0 0 0 A0A9Q1H119 A0A9Q1H119_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_30337 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] 1 0.5 1.012 -23.777 GPAASAVS 0 0 0 0 0 0 0 0 0 0 20.3748 20.3748 0 0 0 0 0 0 A0A9Q1H126 A0A9Q1H126_HOLLE Follistatin HOLleu_29084 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular space [GO:0005615] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840] 2 4.2 1.0107 -12.499 CSTFLCMEGRSCV;DSQDCSTFLCMEG 25.1914 19.8613 19.8613 0 0 0 22.1161 21.8069 21.8069 0 22.9346 22.9346 0 0 0 0 0 15.5572 A0A9Q1H157 A0A9Q1H157_HOLLE Retrotransposon gag domain-containing protein HOLleu_28746 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.1 0.93299 -0.068637 GAVNTRNN 0 0 0 0 0 0 0 0 0 23.0374 22.3972 22.3972 0 0 0 0 0 0 A0A9Q1H163 A0A9Q1H163_HOLLE Amyloid-beta A4 protein-binding family A member 1 HOLleu_28761 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chemical synaptic transmission [GO:0007268] cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540] 2 1.8 0.99927 -28.854 EDNVDSNEYAEDDSYNH;FEDAESDHQTL 18.8837 24.8219 24.8219 0 0 0 0 0 0 19.1657 18.7744 18.7744 16.2192 0 0 0 0 0 A0A9Q1H171 A0A9Q1H171_HOLLE Uncharacterized protein HOLleu_29234 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4 1.0288 -23.442 WGCGCDPDSDET 0 20.8084 20.8084 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H181 A0A9Q1H181_HOLLE Chordin-like protein 1 HOLleu_27989 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; negative regulation of BMP signaling pathway [GO:0030514] extracellular space [GO:0005615] BMP binding [GO:0036122] 1 3.9 1.0163 -21.924 CCPVCTSEGMPILYS 0 0 0 0 0 0 0 16.6207 16.6207 0 0 0 0 0 0 0 0 0 A0A9Q1H183 A0A9Q1H183_HOLLE Death domain-containing protein HOLleu_28105 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] cytoplasm [GO:0005737] 3 1.6 0.99673 -29.804 LLNKPIIPILIE;NKPIIPILI;PPGPMSMT 0 0 0 22.2517 22.5471 22.5471 0 22.7779 22.7779 23.1902 0 0 18.6817 0 0 0 23.358 24.358 A0A9Q1H186 A0A9Q1H186_HOLLE Uncharacterized protein HOLleu_28828 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.5 0.99704 -4.7869 CTCDTDECVSEDQLSEYG 0 0 0 0 0 0 0 25.8102 25.8102 0 0 0 0 0 0 0 0 0 A0A9Q1H189 A0A9Q1H189_HOLLE Ig-like domain-containing protein HOLleu_28032 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 0.99787 -4.979 NSTETNDDCC 0 20.4349 20.4349 0 0 0 0 0 0 21.7928 21.1847 21.1847 20.7677 20.74 20.74 0 0 0 A0A9Q1H192 A0A9Q1H192_HOLLE Thrombospondin type-1 domain-containing protein 4 HOLleu_28142 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] 1 1.2 1.0225 -5.5496 NEQDYDYSSYS 28.0878 0 0 0 0 0 0 0 0 24.3863 17.4618 17.4618 0 0 0 0 0 0 A0A9Q1H195 A0A9Q1H195_HOLLE Cation channel sperm-associated protein 2 HOLleu_28873 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] CatSper complex [GO:0036128] calcium-activated cation channel activity [GO:0005227] 1 2.8 0.97656 -0.71462 EEDEESVMSSGMDSF 0 0 0 0 0 0 0 21.4816 21.4816 17.5537 16.6526 16.6526 0 0 0 0 0 0 A0A9Q1H1C2 A0A9Q1H1C2_HOLLE Serine incorporator 5 HOLleu_28973 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.6 1.0124 -23.777 SRSRRGGK 16.282 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H1F4 A0A9Q1H1F4_HOLLE Laminin-like protein epi-1 HOLleu_29562 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] basement membrane [GO:0005604] 1 0.3 1.0186 -23.723 GGSSTDFDR 0 0 0 0 0 0 20.7477 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H1G0 A0A9Q1H1G0_HOLLE Serine/threonine-protein kinase ATR (EC 2.7.11.1) HOLleu_29119 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; phosphorylation [GO:0016310]; telomere maintenance [GO:0000723] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; protein serine/threonine kinase activity [GO:0004674] 2 0.7 1.0071 -24.175 KQECFQDM;LKILRAKVLP 0 0 0 0 0 0 21.017 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H1K3 A0A9Q1H1K3_HOLLE Tubulin polyglutamylase complex subunit 2 HOLleu_28596 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7 1.0082 -2.5328 SDIDYDTDDDDDDTKDFGEAQT 0 0 0 0 0 0 0 0 0 0 0 23.1275 0 0 0 0 0 0 A0A9Q1H1K7 A0A9Q1H1K7_HOLLE Glutamate receptor 1 HOLleu_28618 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" postsynaptic density membrane [GO:0098839] glutamate receptor activity [GO:0008066]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] 2 0.5 1.006 -23.845 AGGGAPDA;GGGAPDAA 0 0 0 0 0 0 0 0 0 0 0 0 22.3608 16.746 16.746 0 0 0 A0A9Q1H1M1 A0A9Q1H1M1_HOLLE Breast cancer anti-estrogen resistance protein 3 HOLleu_29335 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of peptidyl-serine phosphorylation [GO:0033138]; signal transduction [GO:0007165] 2 3.4 1.0204 -5.5713 NSYDSKQSHEDHYSDD;VGKKLGVH 22.5378 22.9086 22.9086 0 16.2985 16.2985 19.9481 19.2781 19.2781 21.358 23.2426 23.2426 17.759 19.0404 19.0404 0 0 0 A0A9Q1H1M4 A0A9Q1H1M4_HOLLE C-Jun-amino-terminal kinase-interacting protein 4 HOLleu_31043 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737] JUN kinase binding [GO:0008432]; kinase activity [GO:0016301]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159] 1 0.6 1.0128 -23.777 FYSSSTEE 0 0 0 0 0 0 16.6065 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H1N0 A0A9Q1H1N0_HOLLE Fibropellin-1 HOLleu_25089 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509] 6 2.1 0.99891 -33.073 AGTRGCVC;CDPLCPEGMVYDSCG;FYSCACPEGYLGDNCEEDVNE;NEDCSQYC;PYGTTYNSCGDPCPSTCGNEEANNE;YDSCGSPCQTTC 26.252 27.1409 27.1409 22.6514 0 22.1289 26.0323 24.2611 24.2611 26.6827 26.1288 26.1288 24.5702 24.1334 24.1334 19.5645 0 0 A0A9Q1H1N7 A0A9Q1H1N7_HOLLE Mucin-4 HOLleu_29393 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] calcium ion binding [GO:0005509] 2 0.6 1.0104 -6.9947 CDCAQCTDEAEELCCAMD;RTCDFFCDCAQCTDEAEELCCAM 20.9314 22.0926 22.0926 0 0 0 0 24.1079 24.1079 0 17.7415 17.7415 0 0 0 0 0 0 A0A9Q1H1P6 A0A9Q1H1P6_HOLLE Helicase senataxin HOLleu_25174 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) termination of RNA polymerase II transcription [GO:0006369] nuclear body [GO:0016604] helicase activity [GO:0004386]; transcription termination site sequence-specific DNA binding [GO:0001147] 1 0.3 0.94359 -0.068637 SSGGGHRG 0 0 0 0 0 0 0 0 0 0 0 0 0 21.3936 21.3936 0 0 0 A0A9Q1H1S4 A0A9Q1H1S4_HOLLE Hyalin HOLleu_28855 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.3 1.0152 -5.7538 CEFTNDDLPGSAECQ 0 0 0 0 16.5407 16.5407 0 0 0 23.9809 0 0 17.6419 0 0 0 0 0 A0A9Q1H1U1 A0A9Q1H1U1_HOLLE Fibronectin type-III domain-containing protein HOLleu_29578 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.7 0.94388 -0.068637 PPAGFPGG 0 0 0 0 0 0 20.7527 20.9594 20.9594 0 0 0 0 0 0 0 0 0 A0A9Q1H1U7 A0A9Q1H1U7_HOLLE Ovochymase-2 HOLleu_28931 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] 1 2.3 1.016 -2.2078 YCDSSGRCLCDDGFEMMFGVCID 0 0 0 0 0 0 0 23.6781 23.6781 0 0 0 0 0 0 0 0 0 A0A9Q1H1V1 A0A9Q1H1V1_HOLLE Interferon-induced very large GTPase 1 HOLleu_25445 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924] 1 0.5 0.72973 -0.068637 SMARLPLK 0 0 0 19.1556 0 0 19.684 0 0 21.9907 0 0 21.3719 0 0 0 0 0 A0A9Q1H1V4 A0A9Q1H1V4_HOLLE Kin of IRRE-like protein 1 HOLleu_29617 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 1.0206 -5.5496 IPLNIKPKVQI 0 0 0 0 0 0 24.091 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H1V5 A0A9Q1H1V5_HOLLE Lysyl oxidase-like 4 HOLleu_26845 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2 1.0158 -5.7538 AYEESNFDPCETDYS 19.7367 22.9593 22.9593 0 0 0 16.6352 0 0 0 20.6451 20.6451 0 0 0 0 0 0 A0A9Q1H1W4 A0A9Q1H1W4_HOLLE Renin receptor HOLleu_26884 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of Wnt signaling pathway [GO:0030177] bounding membrane of organelle [GO:0098588]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897] signaling receptor activity [GO:0038023] 1 2.2 0.93909 -0.068637 EEYGTGSD 0 0 0 0 0 0 0 0 0 0 23.8776 23.8776 0 0 0 0 0 0 A0A9Q1H1X2 A0A9Q1H1X2_HOLLE Uncharacterized protein HOLleu_25534 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.9 0.71795 -0.068637 RYNSNCHT 0 23.3061 23.3061 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H1X4 A0A9Q1H1X4_HOLLE Endonuclease HOLleu_28379 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; RNA-directed DNA polymerase activity [GO:0003964] 1 0.6 1 -4.979 LYAPRRKKGL 0 0 0 0 0 0 0 21.8271 21.8271 0 0 0 0 0 0 0 0 0 A0A9Q1H1Y7 A0A9Q1H1Y7_HOLLE receptor protein-tyrosine kinase (EC 2.7.10.1) HOLleu_28440 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 2 3 1.0217 -5.5713 LGGSVIKK;MNSFTSDYEDYSSDEE 23.3286 0 0 22.7632 24.1757 24.1757 23.8743 0 0 0 0 0 22.5708 22.9848 22.9848 0 0 16.7444 A0A9Q1H201 A0A9Q1H201_HOLLE Receptor-type tyrosine-protein phosphatase F HOLleu_28491 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 0.93434 -0.068637 PTGASLSL 0 0 0 0 0 0 0 0 0 0 21.747 21.747 0 0 0 0 0 0 A0A9Q1H232 A0A9Q1H232_HOLLE Polycomb group protein Pc HOLleu_25817 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064] 1 3.1 1.0007 -4.979 MELCSMTNYS 0 0 0 0 0 0 22.5753 22.201 22.201 0 0 0 0 0 0 0 0 0 A0A9Q1H238 A0A9Q1H238_HOLLE Cytochrome P450 2U1 HOLleu_28658 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) organic acid metabolic process [GO:0006082]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]" 1 1.6 0.93782 -0.068637 QGWSSSSS 0 0 0 0 0 0 0 0 0 0 0 0 20.5946 0 0 0 0 0 A0A9Q1H252 A0A9Q1H252_HOLLE Lengsin (Glutamate-ammonia ligase domain-containing protein 1) HOLleu_29278 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutamine biosynthetic process [GO:0006542]; lens morphogenesis in camera-type eye [GO:0002089]; nitrogen utilization [GO:0019740] cytoplasm [GO:0005737]; membrane [GO:0016020] glutamine synthetase activity [GO:0004356] 1 2.6 1.0069 -6.2493 INRQLLLPKALPL 0 0 0 23.3623 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H253 A0A9Q1H253_HOLLE Circularly permutated Ras protein 1 HOLleu_25914 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; endoplasmic reticulum exit site [GO:0070971] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] 1 1 1.0128 -23.777 KPIICERC 0 0 0 18.2708 18.767 18.767 0 0 20.0152 21.3249 21.4255 21.4255 0 0 0 17.7902 0 18.3048 A0A9Q1H277 A0A9Q1H277_HOLLE FERM domain-containing protein 3 HOLleu_28815 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoskeleton [GO:0005856]; membrane [GO:0016020] 1 4 0.96053 -0.17167 KGSSILLKVLLTLVLLICAIVVFVV 0 0 0 0 0 0 0 0 0 22.6898 21.9588 21.9588 0 0 0 0 0 0 A0A9Q1H289 A0A9Q1H289_HOLLE RNA-binding protein 28 HOLleu_26068 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleolus [GO:0005730] mRNA binding [GO:0003729] 1 1.1 1 -4.979 NGHDDDDGKN 0 0 0 0 0 0 0 21.6797 21.6797 0 0 0 0 0 0 0 0 0 A0A9Q1H2A2 A0A9Q1H2A2_HOLLE Uncharacterized protein HOLleu_26844 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.4 0.99858 -4.979 TNQDDDYDDD 0 0 0 0 0 0 0 0 0 24.7932 0 0 0 0 0 0 0 0 A0A9Q1H2A9 A0A9Q1H2A9_HOLLE LIM domain-containing protein HOLleu_27407 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925] metal ion binding [GO:0046872] 1 3.7 1.0141 -6.0118 GECWHEECFVCA 0 0 0 0 0 0 0 22.1769 22.1769 0 0 0 0 0 0 0 0 0 A0A9Q1H2E0 A0A9Q1H2E0_HOLLE Uncharacterized protein HOLleu_27522 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 0.8 1.012 -23.777 PKKFRVMV 0 0 0 0 0 0 20.6268 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H2F1 A0A9Q1H2F1_HOLLE CAP-Gly domain-containing protein HOLleu_27569 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasmic microtubule organization [GO:0031122]; establishment of mitotic spindle orientation [GO:0000132] axon [GO:0030424]; cell tip [GO:0051286]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; spindle pole [GO:0000922] microtubule plus-end binding [GO:0051010] 1 2.9 0.9397 -0.068637 SASWHAGM 26.1032 27.8367 27.8367 0 0 0 26.4634 0 0 25.7621 25.8125 25.8125 25.97 25.7489 25.7489 0 0 0 A0A9Q1H2F3 A0A9Q1H2F3_HOLLE NLR family CARD domain-containing protein 4 HOLleu_27022 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.6 0.99567 -0.31124 RLLRRSVIQLLEIVSSHKIMVKIL 0 0 0 0 0 0 0 0 0 22.952 0 0 0 0 0 0 0 0 A0A9Q1H2F7 A0A9Q1H2F7_HOLLE Sorting nexin-27 HOLleu_29141 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular protein transport [GO:0006886]; signal transduction [GO:0007165] early endosome [GO:0005769]; membrane [GO:0016020] phosphatidylinositol binding [GO:0035091] 1 2.9 1.0106 -2.6427 PGKKRRGVK 0 0 0 21.4419 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H2F9 A0A9Q1H2F9_HOLLE C2H2-type domain-containing protein HOLleu_22774 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 0.71053 -0.068637 MGDYCDSL 0 0 0 0 0 0 0 0 0 0 22.4418 22.4418 0 0 0 0 0 0 A0A9Q1H2G1 A0A9Q1H2G1_HOLLE WD repeat-containing protein 44 HOLleu_27611 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.9 1.0108 -23.777 YSPDECPD 0 0 0 0 0 0 18.8825 19.0934 19.0934 0 0 0 0 0 0 0 0 0 A0A9Q1H2H5 A0A9Q1H2H5_HOLLE Uncharacterized protein HOLleu_26452 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 0.935 -0.068637 PKIHKLRA 0 22.976 22.976 18.8732 20.7647 20.7647 21.3131 21.6457 21.6457 22.5123 22.5401 22.5401 0 0 0 18.0354 0 19.3967 A0A9Q1H2I7 A0A9Q1H2I7_HOLLE Uncharacterized protein HOLleu_27705 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 12.4 1.0105 -5.5027 SYNSYDGWPSYDNYFS 0 24.7683 24.7683 0 0 0 0 0 0 0 23.5407 23.5407 0 0 0 0 0 0 A0A9Q1H2I9 A0A9Q1H2I9_HOLLE Uncharacterized protein HOLleu_27144 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.2 1.0079 -23.777 SCACFMGT 17.5319 19.7144 19.7144 0 0 0 0 0 0 19.1131 18.4523 18.4523 0 0 0 0 0 0 A0A9Q1H2K6 A0A9Q1H2K6_HOLLE Reverse transcriptase HOLleu_22971 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA metabolic process [GO:0006259] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 2 1.3 0.93035 -0.068637 DSYLKRFER;GHVVGKGI 0 0 0 20.1327 18.1932 18.1932 0 20.7895 20.7895 0 0 0 0 0 0 18.963 0 18.0866 A0A9Q1H2K8 A0A9Q1H2K8_HOLLE Paraoxonase (EC 3.1.1.2) HOLleu_27795 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) response to toxic substance [GO:0009636] arylesterase activity [GO:0004064]; metal ion binding [GO:0046872] 1 2.9 1.0256 -23.631 YEVYYDDAHLM 18.2981 18.9033 18.9033 0 0 0 0 0 0 18.8727 18.1522 18.1522 18.128 18.4332 18.4332 0 0 0 A0A9Q1H2M7 A0A9Q1H2M7_HOLLE Sister chromatid cohesion protein DCC1 HOLleu_23067 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) maintenance of mitotic sister chromatid cohesion [GO:0034088] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; Ctf18 RFC-like complex [GO:0031390]" 1 3.7 1.0074 -6.2493 DRFNFLFKTKERW 23.0851 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H2N6 A0A9Q1H2N6_HOLLE RBR-type E3 ubiquitin transferase (EC 2.3.2.31) HOLleu_23108 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 2 5.1 0.99893 -47.554 LCHCRDEE;QMENCTCV 0 0 0 18.1726 0 0 18.7426 18.5314 18.5314 0 0 0 0 0 0 20.3791 0 0 A0A9Q1H2N7 A0A9Q1H2N7_HOLLE Thymus-specific serine protease HOLleu_27333 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] vacuole [GO:0005773] dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008] 1 2 1.0233 -23.675 WLYQTCTEFG 0 0 0 0 0 0 0 17.6632 17.6632 0 0 0 0 0 0 0 0 0 A0A9Q1H2S8 A0A9Q1H2S8_HOLLE "RNA-binding motif protein, X chromosome" HOLleu_27476 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular membrane-bounded organelle [GO:0043231] mRNA binding [GO:0003729] 1 1.4 0.92574 -0.068637 AREPAHAR 0 0 0 0 0 0 0 0 0 21.7192 22.1661 22.1661 0 0 0 0 0 0 A0A9Q1H2U5 A0A9Q1H2U5_HOLLE Malignant fibrous histiocytoma-amplified sequence 1-like HOLleu_23333 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 4 1.0147 -6.0118 MDYEDGSSPEDH 0 0 0 0 0 0 0 0 0 21.9727 0 0 0 0 0 0 0 0 A0A9Q1H2Y0 A0A9Q1H2Y0_HOLLE von Willebrand factor A domain-containing protein 8 HOLleu_27041 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] 1 0.4 1.0071 -23.777 QPHVGGGM 19.5948 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H341 A0A9Q1H341_HOLLE Lengsin (Glutamate-ammonia ligase domain-containing protein 1) HOLleu_27262 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glutamine biosynthetic process [GO:0006542]; lens morphogenesis in camera-type eye [GO:0002089]; nitrogen utilization [GO:0019740] cytoplasm [GO:0005737]; membrane [GO:0016020] glutamine synthetase activity [GO:0004356] 1 2 1.0115 -2.6427 NHSLWDQME 19.3799 0 0 0 0 0 0 0 0 22.8954 0 0 0 0 0 0 0 0 A0A9Q1H356 A0A9Q1H356_HOLLE Ig-like domain-containing protein HOLleu_27953 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.1 1.0137 -2.6427 SDNGNMYQC 0 0 0 0 0 0 0 0 0 23.2082 0 0 0 0 0 0 0 0 A0A9Q1H361 A0A9Q1H361_HOLLE MYND-type domain-containing protein HOLleu_23856 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 1.8 1.0247 -23.631 AGVLKPLEPLL 0 0 0 0 0 0 0 0 0 22.0616 0 0 0 0 0 0 0 0 A0A9Q1H380 A0A9Q1H380_HOLLE Vacuolar segregation protein PEP7 HOLleu_27426 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872] 1 1.5 1.0173 -16.819 SRDKSISESAATGRKTT 0 18.8319 18.8319 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H3A8 A0A9Q1H3A8_HOLLE [histone H3]-lysine(27) N-trimethyltransferase (EC 2.1.1.356) HOLleu_27524 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterochromatin formation [GO:0031507]; methylation [GO:0032259] ESC/E(Z) complex [GO:0035098] chromatin binding [GO:0003682]; histone H3K27 methyltransferase activity [GO:0046976] 2 18.8 1.0184 -23.743 DHPGNCDSDC;NCDSDCTCIMLQSFCEKYCQCSTEC 18.0861 19.1321 19.1321 0 0 0 0 20.73 20.73 0 0 0 0 0 0 0 0 0 A0A9Q1H3B8 A0A9Q1H3B8_HOLLE Mitochondrial intermediate peptidase HOLleu_27570 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) peptide metabolic process [GO:0006518]; protein processing involved in protein targeting to mitochondrion [GO:0006627] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 2.9 1.0023 -4.125 AWDSHFLIQHVRNEKFKINN 0 0 0 0 0 0 0 0 0 0 22.3934 22.3934 0 0 0 0 0 0 A0A9Q1H3F3 A0A9Q1H3F3_HOLLE Carbohydrate sulfotransferase 15 HOLleu_27706 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) hexose biosynthetic process [GO:0019319] N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659] 1 1.5 1.0266 -23.723 CWMGDDQKV 0 0 0 0 0 0 0 0 0 19.561 0 0 0 0 0 0 0 0 A0A9Q1H3F5 A0A9Q1H3F5_HOLLE 46 kDa FK506-binding nuclear protein HOLleu_24723 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.2 1.0071 -23.777 RGVKRPRD 0 0 0 0 0 0 20.2988 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H3J1 A0A9Q1H3J1_HOLLE Ficolin-1 HOLleu_24425 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.5 0.92611 -0.068637 RDSCACQN 20.8554 21.7324 21.7324 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H3J8 A0A9Q1H3J8_HOLLE Reticulocyte-binding protein 2-like a HOLleu_25537 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 1.0075 -23.777 SDGEADME 0 0 0 0 0 0 0 0 0 0 21.0905 21.0905 0 0 0 0 0 0 A0A9Q1H3K8 A0A9Q1H3K8_HOLLE SWIM-type domain-containing protein HOLleu_25583 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zinc ion binding [GO:0008270] 1 1.6 0.99929 -4.979 PRLQALLPKL 0 0 0 0 0 0 0 0 0 0 0 0 0 20.9676 20.9676 0 0 0 A0A9Q1H3Q0 A0A9Q1H3Q0_HOLLE Neurogenic locus notch-like protein 1 HOLleu_20953 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 0.8 1.0079 -23.777 MYMDIPTM 0 0 0 0 17.0864 0 0 0 0 21.1296 0 0 0 0 0 0 0 0 A0A9Q1H3R4 A0A9Q1H3R4_HOLLE guanylate cyclase (EC 4.6.1.2) HOLleu_27833 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cGMP-mediated signaling [GO:0019934]; response to oxygen levels [GO:0070482] "guanylate cyclase complex, soluble [GO:0008074]" GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037] 2 2.9 1.0087 -7.9276 DGANDTEN;EYFFTFCQRSGYDEM 0 0 0 0 0 0 0 0 0 0 22.0482 22.0482 0 0 0 0 0 0 A0A9Q1H3T9 A0A9Q1H3T9_HOLLE C2H2-type domain-containing protein HOLleu_25899 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.4 0.99781 -4.979 DSDPDSDTEE 19.4904 25.4147 25.4147 0 0 0 0 0 0 17.4538 23.9756 23.9756 0 0 0 0 0 0 A0A9Q1H3W3 A0A9Q1H3W3_HOLLE Uncharacterized protein HOLleu_24768 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023] 3 8.3 0.99854 -28.947 DDGDDGDD;DDNDDDEFN;DFTCVCEDCYQGATCEI 0 0 0 0 0 0 0 21.9014 21.9014 0 0 0 22.5757 0 0 0 0 0 A0A9Q1H3Y8 A0A9Q1H3Y8_HOLLE Sushi domain-containing protein 2 HOLleu_24612 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.8 1.0228 -23.675 VQCCYNDMGD 0 0 0 0 0 0 19.1747 18.4667 18.4667 0 0 0 0 0 0 0 0 0 A0A9Q1H402 A0A9Q1H402_HOLLE Ig-like domain-containing protein HOLleu_24668 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 3.1 0.996 -29.643 INILILHIIIPS;NILILHIIIPS 21.7815 0 0 0 0 0 0 0 0 0 21.8785 21.8785 21.9345 20.3604 0 0 0 0 A0A9Q1H430 A0A9Q1H430_HOLLE BEN domain-containing protein HOLleu_24791 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA binding [GO:0003677] 1 2 1.0284 -23.442 LQVIIDRLPPVV 0 0 0 0 19.4115 19.4115 0 0 0 0 0 0 0 0 0 20.8405 0 20.5537 A0A9Q1H447 A0A9Q1H447_HOLLE Natterin-4 HOLleu_25624 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.2 1.0015 -4.564 CDTLPDRSDQFDCEWIDNC 0 0 0 0 0 0 21.5656 0 0 0 23.2206 23.2206 22.9299 21.2279 21.2279 0 0 0 A0A9Q1H458 A0A9Q1H458_HOLLE Tyrosine kinase receptor Cad96Ca HOLleu_21684 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] 1 3.4 0.99367 -0.31124 LHKLKYGTQNGYGRRNRSYRSREN 0 22.7062 22.7062 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H490 A0A9Q1H490_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_25042 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] kinase activity [GO:0016301] 1 1.2 0.91707 -0.068637 DYYYDMEP 0 23.7793 23.7793 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H494 A0A9Q1H494_HOLLE Basic helix-loop-helix domain-containing protein USF3 HOLleu_21830 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein dimerization activity [GO:0046983] 1 0.8 1.0124 -5.5027 KLGDTQEGDDCLDAND 0 0 0 0 0 0 0 0 0 21.3262 0 0 0 0 0 0 0 0 A0A9Q1H4D1 A0A9Q1H4D1_HOLLE Uncharacterized protein HOLleu_25180 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 25.3 1.0031 -4.125 FTYGYEDGGDEDEDEIEDSS 0 0 0 0 0 0 0 0 0 0 21.7073 21.7073 0 0 0 0 0 0 A0A9Q1H4D2 A0A9Q1H4D2_HOLLE Phospholipase (EC 3.1.4.4) HOLleu_25969 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; regulation of vesicle-mediated transport [GO:0060627] intracellular membrane-bounded organelle [GO:0043231]; plasma membrane region [GO:0098590] N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630] 1 0.6 0.70455 -0.068637 ICSCCPSC 0 0 0 0 18.0889 0 0 0 0 0 26.3662 26.3662 0 0 0 0 0 0 A0A9Q1H4D4 A0A9Q1H4D4_HOLLE Ig-like domain-containing protein HOLleu_22017 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 6 0.99577 -0.31124 PFAFAVVVLLVGLIRRIIHKWRRA 0 0 0 0 0 0 0 0 0 23.4548 0 0 0 0 0 0 0 0 A0A9Q1H4I2 A0A9Q1H4I2_HOLLE Fibrillin-2 HOLleu_22252 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 1 0.6 1.0117 -6.0779 IDECSVEDEMPCHH 22.0799 22.9805 22.9805 0 15.5097 15.5097 0 0 0 23.4701 22.6541 22.6541 16.3857 0 0 0 0 0 A0A9Q1H4J7 A0A9Q1H4J7_HOLLE Angiopoietin-related protein 1 HOLleu_23205 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.5 1.0083 -23.777 HSGDGGEG 0 0 0 0 0 0 0 19.4843 19.4843 0 0 0 0 0 0 0 0 0 A0A9Q1H4M8 A0A9Q1H4M8_HOLLE Kielin/chordin-like protein HOLleu_25608 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of BMP signaling pathway [GO:0030513] extracellular region [GO:0005576] BMP binding [GO:0036122]; oxidoreductase activity [GO:0016491]; serine-type endopeptidase inhibitor activity [GO:0004867] 1 0.7 1.0083 -6.0779 PDDDCQICSCQFGS 24.3972 0 0 0 0 0 0 0 0 0 22.9346 22.9346 17.7375 18.0624 18.0624 0 0 0 A0A9Q1H4P7 A0A9Q1H4P7_HOLLE Histone-lysine N-methyltransferase PRDM9 HOLleu_22838 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] 2 6.9 1.0177 -16.945 CEDCQEFYETG;DDHFIYCEDCQEFYETGCL 0 22.0487 22.0487 0 0 0 0 0 0 23.6243 0 0 0 18.9271 18.9271 0 0 0 A0A9Q1H4Q9 A0A9Q1H4Q9_HOLLE Monocarboxylate transporter 9 HOLleu_22875 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] monocarboxylic acid transmembrane transporter activity [GO:0008028] 1 1.6 1.0081 -2.6427 KLPLYFKLK 22.202 0 0 0 21.4832 21.4832 24.1252 0 0 25.0032 0 0 0 0 0 0 0 0 A0A9Q1H4X5 A0A9Q1H4X5_HOLLE Uncharacterized protein HOLleu_23654 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676] 1 6.2 1.0165 -2.6427 LLMGRIVRT 0 22.7716 22.7716 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H4X6 A0A9Q1H4X6_HOLLE Protein kinase C-binding protein NELL2 HOLleu_26195 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] cytoplasm [GO:0005737]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; kinase activity [GO:0016301]; protein kinase C binding [GO:0005080] 2 2.9 1.0208 -19.398 GSHHCECN;SCCEFCNGHNFCSSEN 0 18.7835 18.7835 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H506 A0A9Q1H506_HOLLE "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" HOLleu_19472 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 0.2 1.0139 -5.7538 STLNLCDENAECMNM 0 0 0 0 0 0 22.207 22.0361 22.0361 0 0 0 0 0 0 0 0 0 A0A9Q1H565 A0A9Q1H565_HOLLE Galectin-3-binding protein B HOLleu_22826 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3.1 1.0028 -4.979 MAYDDEVFCQ 23.5811 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H574 A0A9Q1H574_HOLLE Uncharacterized protein HOLleu_23412 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 1.0253 -23.723 TRSDDENNP 0 19.5192 19.5192 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H598 A0A9Q1H598_HOLLE CAD protein HOLleu_23492 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; citrulline biosynthetic process [GO:0019240]; glutamine metabolic process [GO:0006541]; UTP biosynthetic process [GO:0006228] cytosol [GO:0005829] amino acid binding [GO:0016597]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; metal ion binding [GO:0046872] 1 0.4 1.0091 -23.777 GAAMNVAH 0 0 0 0 0 0 21.247 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H5C0 A0A9Q1H5C0_HOLLE Fibrinogen C domain-containing protein 1 HOLleu_23038 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.5 0.91748 -0.068637 KHRGGWWYVDDYYYYYYYFYFYHDC 0 0 0 0 0 0 18.3111 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H5C1 A0A9Q1H5C1_HOLLE Ryncolin-4 HOLleu_23592 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 1 3.1 1.0169 -21.924 YSYNCATYYYYCSYN 0 0 0 0 0 0 0 0 0 0 0 0 0 19.7384 19.7384 0 0 0 A0A9Q1H5C7 A0A9Q1H5C7_HOLLE Transposable element P transposase HOLleu_19956 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA binding [GO:0003677] 2 1.1 1.0065 -2.7113 ILPKRRRP;LPKRRRPPL 19.3094 23.0513 23.0513 15.8913 0 0 21.0513 23.0034 23.0034 23.6268 0 0 21.3861 0 0 16.3268 0 0 A0A9Q1H5C9 A0A9Q1H5C9_HOLLE Perlucin-like protein HOLleu_23190 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.9 1.0022 -4.979 HLLLWLVLLL 0 21.5267 21.5267 0 0 0 21.747 0 0 0 22.49 22.49 19.4555 20.0033 20.0033 0 0 0 A0A9Q1H5E0 A0A9Q1H5E0_HOLLE Neurensin-1 HOLleu_23114 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nervous system development [GO:0007399] membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133] 1 3.7 1.0234 -23.675 LLLPTLGLTT 0 0 0 0 0 0 0 0 0 0 0 0 0 20.6678 20.6678 0 0 0 A0A9Q1H5F3 A0A9Q1H5F3_HOLLE Tropomodulin-3 HOLleu_20049 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] striated muscle thin filament [GO:0005865] tropomyosin binding [GO:0005523] 1 2.5 1.02 -23.723 PTGPFNRQA 20.0851 0 0 18.5932 19.9029 19.9029 0 19.6141 19.6141 0 0 0 18.7319 0 0 17.5848 0 18.7849 A0A9Q1H5H0 A0A9Q1H5H0_HOLLE Ficolin-1 HOLleu_23337 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] calcium ion binding [GO:0005509] 1 4 1.0036 -2.5328 LCPTNMEYGNCSCQATCEDPRN 0 0 0 0 0 0 22.886 22.7946 22.7946 0 0 0 0 0 0 0 0 0 A0A9Q1H5J5 A0A9Q1H5J5_HOLLE Fibropellin-1 HOLleu_23434 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 1 5 1.0117 -6.0779 CSSNPCENGGSCQS 0 0 0 0 18.5778 0 0 0 0 0 0 0 22.4667 24.1622 24.1622 0 0 0 A0A9Q1H5J6 A0A9Q1H5J6_HOLLE Fibrinogen-like protein 1 HOLleu_23320 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] 2 10.1 1.0049 -25.56 GEHCVPPEECGCF;SCQVTCEDPDGTSGCHNNCTRG 0 0 0 0 0 0 0 22.8358 22.8358 22.8503 0 0 0 0 0 0 0 0 A0A9Q1H5M5 A0A9Q1H5M5_HOLLE Periostin HOLleu_20324 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; macroautophagy [GO:0016236] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] cell adhesion molecule binding [GO:0050839] 1 3.5 1.0211 -5.5496 GLGLSTLAMLV 20.5171 0 0 0 0 0 0 0 0 21.1184 20.0769 20.0769 17.8899 0 0 0 0 0 A0A9Q1H5N0 A0A9Q1H5N0_HOLLE 26S proteasome complex subunit SEM1 HOLleu_20341 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair via homologous recombination [GO:0000724]; mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248] "nucleus [GO:0005634]; proteasome regulatory particle, lid subcomplex [GO:0008541]" 1 8.4 0.92157 -0.068637 DDGNNGAG 0 0 0 0 0 0 20.7151 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H5Q0 A0A9Q1H5Q0_HOLLE Fibrillin-3 HOLleu_20443 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 7.3 0.9884 -0.20876 HVNANCMDLDPLYTCTCQSGFDGD 0 0 0 0 0 0 0 0 0 0 0 0 18.3421 0 0 0 0 0 A0A9Q1H5R3 A0A9Q1H5R3_HOLLE Uridylate-specific endoribonuclease (EC 4.6.1.-) HOLleu_24220 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521] 1 6.2 1.0179 -2.2078 NDQCKSFGNCCSDFDAVDCAAVH 0 0 0 0 0 0 0 22.0473 22.0473 0 0 0 0 0 0 0 0 0 A0A9Q1H5T6 A0A9Q1H5T6_HOLLE Uncharacterized protein HOLleu_23788 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.4 1.0259 -23.442 INEIILIVKKSS 0 0 0 0 0 0 0 0 0 21.2238 0 0 0 0 0 0 0 0 A0A9Q1H5W0 A0A9Q1H5W0_HOLLE Neurogenic locus Notch protein HOLleu_23754 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Notch signaling pathway [GO:0007219] membrane [GO:0016020] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 4 1.4 0.99611 -75.748 CNDGYSGD;IGACDSGPCSNGGTCTDSS;YFCQCSAGFLG;YYYCSCTD 19.113 22.9021 22.9021 0 0 0 19.8137 0 0 0 0 0 20.9663 0 0 0 0 0 A0A9Q1H5W3 A0A9Q1H5W3_HOLLE Ficolin-1 HOLleu_23897 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.9 1.0071 -6.1851 MKILIILLSLWL;YGNCTCQATCEDPENVMECQT 0 0 0 0 0 0 20.527 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H5Z7 A0A9Q1H5Z7_HOLLE acetyl-CoA C-acyltransferase (EC 2.3.1.16) HOLleu_24503 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fatty acid beta-oxidation [GO:0006635] cytosol [GO:0005829]; mitochondrion [GO:0005739] acetyl-CoA C-acetyltransferase activity [GO:0003985] 1 1.9 1.0174 -2.6427 KTKKTLAKT 0 0 0 0 0 0 0 0 0 0 0 0 25.1377 0 0 0 0 0 A0A9Q1H602 A0A9Q1H602_HOLLE Protein FAM91A1 HOLleu_24519 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041] cytoplasmic vesicle [GO:0031410]; trans-Golgi network [GO:0005802] 2 3 1.0099 -7.0558 SYYQKMMHN;YHLSDIIVKGLRVTPFSYYQKM 20.0423 0 0 15.8484 0 0 0 0 0 0 0 0 0 16.9366 16.9366 0 0 0 A0A9Q1H603 A0A9Q1H603_HOLLE Fibrinogen-like protein A HOLleu_23957 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 5.5 0.99817 -29.039 GNGCGACDNSNLN;YYCDYWPEGNGC 22.5733 18.1557 18.1557 0 0 0 0 0 0 0 16.7093 16.7093 0 0 0 0 0 0 A0A9Q1H604 A0A9Q1H604_HOLLE Fibropellin-1 HOLleu_17446 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] biotin binding [GO:0009374]; calcium ion binding [GO:0005509] 2 4.9 1.0101 -10.541 GYTGDFCETDINECM;PCMNGATCNDEIGMYTCT 22.3628 0 0 0 0 0 22.9205 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H623 A0A9Q1H623_HOLLE Fibrinogen C domain-containing protein 1-A HOLleu_24057 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.1 0.99703 -4.7869 QCYCNPGYTGEECGCFMG 0 0 0 0 0 0 0 23.4047 23.4047 0 0 0 0 0 0 21.7081 0 0 A0A9Q1H629 A0A9Q1H629_HOLLE Fibroblast growth factor receptor HOLleu_21492 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of angiogenesis [GO:0045766]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] 1 2.3 0.97936 -0.20876 LLFTAVLVFICCICWKCANRKTTE 0 18.5453 18.5453 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H632 A0A9Q1H632_HOLLE Tenascin-X HOLleu_24102 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.5 1.0099 -23.777 GSATNGMY 0 0 0 0 0 0 0 20.3242 20.3242 0 0 0 0 0 0 0 0 0 A0A9Q1H651 A0A9Q1H651_HOLLE Kinesin-like protein KIF19 HOLleu_17654 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] 1 1.1 1.0143 -6.0118 EVEEEDDDEGSS 0 0 0 0 0 0 0 0 0 0 21.5357 21.5357 0 0 0 0 0 0 A0A9Q1H670 A0A9Q1H670_HOLLE Histone-lysine N-methyltransferase 2A HOLleu_21643 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893] histone methyltransferase complex [GO:0035097] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; zinc ion binding [GO:0008270] 3 0.8 1.0128 -11.696 CDKCHTCYHAECLG;NDCCQVNGDEM;SDVGVPED 25.2232 25.8079 25.8079 0 0 0 0 0 0 22.1359 20.9714 20.9714 0 22.0526 22.0526 0 0 0 A0A9Q1H673 A0A9Q1H673_HOLLE ubiquitinyl hydrolase 1 (EC 3.4.19.12) HOLleu_17767 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] 1 0.9 1.0099 -23.777 RPRQPKKL 0 19.2746 19.2746 0 16.4238 16.4238 19.2318 18.467 18.467 0 19.7838 19.7838 0 15.9189 15.9189 0 0 0 A0A9Q1H694 A0A9Q1H694_HOLLE Fibrinogen-like protein A HOLleu_24375 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 1.0193 -23.723 YTCCENSNC 19.7778 20.423 20.423 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H695 A0A9Q1H695_HOLLE Neurogenic locus Notch protein HOLleu_21119 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 0.5 1.0101 -5.2234 AFSPCSSNPCQNGGSCF 0 22.0784 22.0784 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H6E4 A0A9Q1H6E4_HOLLE Low-density lipoprotein receptor-related protein 2 HOLleu_20840 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 2 11.7 1.0023 -4.4363 EGSDEYNCDGEDDFSFAVNCSPGN;VCDGFNDCQDGSDEDNCGHD 22.4073 21.7065 21.7065 0 0 0 20.6088 19.7631 19.7631 0 0 0 0 0 0 0 0 0 A0A9Q1H6G2 A0A9Q1H6G2_HOLLE DNA-directed DNA polymerase (EC 2.7.7.7) HOLleu_21408 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA replication [GO:0006260] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166] 1 1.8 1.0101 -2.5328 FYENRFEHTCENTCNVCYNGNC 0 0 0 0 0 0 0 24.9904 24.9904 0 0 0 0 0 0 0 0 0 A0A9Q1H6J4 A0A9Q1H6J4_HOLLE Matrix metalloproteinase-14 HOLleu_18248 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] 1 1.5 1.0103 -23.777 GMPHGNAE 0 19.0425 19.0425 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H6L3 A0A9Q1H6L3_HOLLE Fibropellin-1 HOLleu_21122 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 0.7 1.0042 -6.2493 CECVGCFTGYDCQ 0 20.9686 20.9686 0 0 0 21.8436 21.9108 21.9108 0 20.6928 20.6928 18.7371 18.732 18.732 0 0 0 A0A9Q1H6N1 A0A9Q1H6N1_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_22276 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; phosphorylation [GO:0016310] membrane [GO:0016020] kinase activity [GO:0016301]; protein tyrosine phosphatase activity [GO:0004725] 1 0.9 1.0103 -23.777 HQGDMMYC 0 0 0 0 0 0 0 0 0 20.0243 0 0 0 0 0 0 0 0 A0A9Q1H6N4 A0A9Q1H6N4_HOLLE Thyroglobulin type-1 domain-containing protein HOLleu_18399 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] 1 1.6 0.94241 -0.068637 NCAGSGSC 23.5691 0 0 0 16.7432 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H6R1 A0A9Q1H6R1_HOLLE Multiple epidermal growth factor-like domains protein 8 HOLleu_21346 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.4 1.0115 -5.2234 SHCHTYTSCWECLESDG 22.1866 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H6R4 A0A9Q1H6R4_HOLLE Multiple epidermal growth factor-like domains protein 8 HOLleu_21347 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 3 6.6 1.0132 -12.947 ASGDPLRPEGCEQCDCN;MLTIRLIR;QECFCMDNTMG 25.3177 0 0 0 0 0 0 0 0 21.9396 24.1141 24.1141 0 0 0 0 0 0 A0A9Q1H6U2 A0A9Q1H6U2_HOLLE Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (Sorting protein-related receptor containing LDLR class A repeats) HOLleu_21946 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endocytosis [GO:0006897]; Golgi to endosome transport [GO:0006895]; Golgi to vacuole transport [GO:0006896]; protein targeting to vacuole [GO:0006623] early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; transport vesicle membrane [GO:0030658] 3 2.7 1.0112 -13.912 PNYFQCSGWSSGQCFDD;VENCTCTREDYECDEGYME;YWQCDGDLDCPDGSDERDCP 23.3793 25.4307 25.4307 0 0 0 0 23.4944 23.4944 22.5778 0 0 22.4416 0 0 0 0 0 A0A9Q1H6W2 A0A9Q1H6W2_HOLLE Partner and localizer of BRCA2 HOLleu_18683 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair via homologous recombination [GO:0000724] nucleoplasm [GO:0005654] DNA binding [GO:0003677] 1 2.6 1.0168 -21.924 RLRWRGTFKKQDIHR 0 0 0 0 0 0 0 0 0 20.5727 0 0 0 0 0 0 0 0 A0A9Q1H6Y7 A0A9Q1H6Y7_HOLLE Septin-9 HOLleu_18801 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoskeleton-dependent cytokinesis [GO:0061640] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] 1 2.8 1.0248 -23.723 EQIRKKALK 0 0 0 0 0 0 0 0 0 0 0 0 0 20.0661 20.0661 0 0 0 A0A9Q1H6Z0 A0A9Q1H6Z0_HOLLE Ig-like domain-containing protein HOLleu_21668 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.6 1.0178 -23.723 VVVKKKKKR 0 17.0346 17.0346 0 0 0 17.2193 0 0 17.3588 0 0 0 0 0 0 0 0 A0A9Q1H714 A0A9Q1H714_HOLLE Uncharacterized protein HOLleu_18932 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.1 1.0257 -23.631 TTSQWYHKSCY 19.8158 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H745 A0A9Q1H745_HOLLE E3 ubiquitin-protein ligase DCST1 HOLleu_19358 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 4.2 1.0184 -2.6427 KIPLPGVEL 0 23.3818 23.3818 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H751 A0A9Q1H751_HOLLE PiRNA biogenesis protein EXD1 HOLleu_21894 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleobase-containing compound metabolic process [GO:0006139] 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676] 1 2.9 1.0169 -6.0779 ENGGEEEEQDEPMG 0 0 0 0 0 0 0 0 0 20.9625 0 0 0 0 0 0 0 0 A0A9Q1H753 A0A9Q1H753_HOLLE Galactosylceramide sulfotransferase HOLleu_19097 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) glycolipid biosynthetic process [GO:0009247] membrane [GO:0016020] galactosylceramide sulfotransferase activity [GO:0001733] 1 2 1.0095 -23.777 QNETMHKC 0 19.9261 19.9261 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H760 A0A9Q1H760_HOLLE GPR180/TMEM145 transmembrane domain-containing protein HOLleu_21931 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] membrane [GO:0016020] 1 2.3 1.0076 -6.2493 FYICILSLTYVTT 21.3504 23.182 23.182 0 0 0 0 0 0 19.247 0 0 18.1803 18.4196 18.4196 0 0 16.715 A0A9Q1H773 A0A9Q1H773_HOLLE NGFI-A-binding protein 1 HOLleu_19457 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] transcription coregulator activity [GO:0003712] 1 1.3 0.68889 -0.068637 KPLHVRRL 28.5901 0 0 0 0 0 25.5735 0 0 0 30.0748 30.0748 27.8072 28.1882 28.1882 0 0 0 A0A9Q1H776 A0A9Q1H776_HOLLE Hypoxia up-regulated protein 1 HOLleu_22020 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298] endoplasmic reticulum chaperone complex [GO:0034663] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] 1 1.2 1.0164 -6.0779 SGSSDDDKKEDTPV 22.1055 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H783 A0A9Q1H783_HOLLE Influenza virus NS1A-binding protein HOLleu_15565 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.2 1.0133 -5.7538 SHMQDSMSCSNCIEI 0 22.8147 22.8147 0 0 0 0 0 0 0 0 0 18.8593 0 0 0 0 0 A0A9Q1H797 A0A9Q1H797_HOLLE "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" HOLleu_22085 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 3.5 1.0086 -10.482 CPEGSYCTSTMVSACT;CTECSAGYFC 0 22.9485 22.9485 0 0 0 0 22.7409 22.7409 0 0 0 0 0 0 0 0 0 A0A9Q1H7A0 A0A9Q1H7A0_HOLLE Mucin-4 HOLleu_15655 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell-matrix adhesion [GO:0007160] membrane [GO:0016020] calcium ion binding [GO:0005509] 4 2 0.99681 -63.125 DECQLGDNDCDESADCFNT;NECEEDHDC;NINECDDFNNCH;SNCDVRCTCHGNNNYTCES 0 24.1973 24.1973 0 0 0 0 0 0 19.4055 0 0 0 20.7434 20.7434 0 0 0 A0A9Q1H7C5 A0A9Q1H7C5_HOLLE Kielin/chordin-like protein HOLleu_22255 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 0.3 1.0235 -23.723 CPMSNDCEH 0 0 0 0 0 0 0 0 0 19.7691 0 0 0 0 0 0 0 0 A0A9Q1H7E9 A0A9Q1H7E9_HOLLE Low-density lipoprotein receptor-related protein 8 HOLleu_15873 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.7 1.0114 -11.395 PLYDFGEDDPYACSSSPCE 0 0 0 0 0 0 0 0 0 0 0 0 0 18.6253 18.6253 0 0 0 A0A9Q1H7G3 A0A9Q1H7G3_HOLLE Uncharacterized protein HOLleu_15924 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cobalamin transport [GO:0015889] extracellular space [GO:0005615] cobalamin binding [GO:0031419] 1 1.6 1.0132 -23.777 DDDESCHG 0 0 0 0 0 0 0 0 0 18.0654 0 0 0 0 0 0 0 0 A0A9Q1H7G4 A0A9Q1H7G4_HOLLE Neogenin HOLleu_19244 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axon guidance [GO:0007411]; brain development [GO:0007420] axon [GO:0030424]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] 2 1.3 0.99583 -1.3234 RPRASGTT;WATCCPCCCSDEEECAGFC 0 23.712 23.712 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H7K3 A0A9Q1H7K3_HOLLE Collagen alpha-1(XXVII) chain B HOLleu_19378 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] 1 0.3 0.8945 -0.068637 DGDAGPQG 21.9492 0 0 0 19.3993 0 24.1 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H7M6 A0A9Q1H7M6_HOLLE E3 ubiquitin-protein ligase UBR4 HOLleu_16192 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] calmodulin binding [GO:0005516]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] 2 0.4 1.026 -23.425 KPTVWHKAKK;TCTVERYDSCWEM 0 0 0 0 0 0 17.3043 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H7M7 A0A9Q1H7M7_HOLLE Fibroblast growth factor receptor 3 HOLleu_22718 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] 1 1.2 1.0183 -2.6427 MAENAPDYD 19.5707 20.9294 20.9294 0 0 0 0 0 0 19.1657 18.789 18.789 0 0 0 0 0 0 A0A9Q1H7Q4 A0A9Q1H7Q4_HOLLE CDC42 small effector protein 2-A HOLleu_19303 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023] cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] small GTPase binding [GO:0031267] 1 9.7 1.0171 -2.6427 LCFSCCCTE 20.2851 21.7463 21.7463 0 0 0 0 0 0 20.5443 19.7663 19.7663 15.9138 0 0 0 0 0 A0A9Q1H7Q9 A0A9Q1H7Q9_HOLLE CCHC-type domain-containing protein HOLleu_20096 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 2.6 1.012 -23.777 RKRALLLH 21.4571 0 0 0 20.2356 0 0 0 0 0 0 0 20.1995 20.3658 20.3658 0 0 0 A0A9Q1H7R2 A0A9Q1H7R2_HOLLE Chromosome transmission fidelity protein 18-like HOLleu_22758 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] 1 2.5 1.0188 -21.924 YIFNRYMPFIPVMFH 0 0 0 0 0 0 0 0 0 19.7334 0 0 0 0 0 0 0 0 A0A9Q1H7R3 A0A9Q1H7R3_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_19339 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) animal organ morphogenesis [GO:0009887]; phosphorylation [GO:0016310] cilium [GO:0005929]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] 2 1.8 1.0283 -23.47 DNDADCSDEAGAL;LPKRRSKKRKRML 0 18.9122 18.9122 0 0 0 0 0 0 17.5391 16.8485 16.8485 0 0 0 0 0 0 A0A9Q1H7U3 A0A9Q1H7U3_HOLLE "glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39)" HOLleu_20190 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell wall organization [GO:0071555]; polysaccharide catabolic process [GO:0000272] cell surface [GO:0009986]; membrane [GO:0016020] "glucan endo-1,3-beta-D-glucosidase activity [GO:0042973]; glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group [GO:0052861]; serine-type endopeptidase inhibitor activity [GO:0004867]" 1 1.1 1.0065 -6.2493 SEERCMEFIYGGC 0 21.2418 21.2418 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H7U4 A0A9Q1H7U4_HOLLE Fibropellin-1 HOLleu_19691 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 1 2.8 1.0208 -21.924 IDECATRPCENDATC 20.5113 0 0 0 0 0 0 0 0 0 19.6819 19.6819 0 0 0 0 0 0 A0A9Q1H7U5 A0A9Q1H7U5_HOLLE Protein prune-like 2 HOLleu_19341 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] exopolyphosphatase activity [GO:0004309]; metal ion binding [GO:0046872] 1 0.2 1.012 -23.777 SDDDGEHS 0 22.9327 22.9327 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H7U7 A0A9Q1H7U7_HOLLE Uncharacterized protein HOLleu_19495 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0081 -6.2493 VIHRKIGVILIQV 0 0 0 0 0 0 0 0 0 0 21.9011 21.9011 0 0 0 0 0 0 A0A9Q1H7V8 A0A9Q1H7V8_HOLLE Receptor ligand binding region domain-containing protein HOLleu_20250 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] membrane [GO:0016020] peptide hormone binding [GO:0017046]; signaling receptor activity [GO:0038023] 1 3.5 0.94652 -0.068637 TLKKGGVV 0 0 0 0 0 0 0 0 0 0 0 0 20.8697 0 0 0 0 0 A0A9Q1H7X1 A0A9Q1H7X1_HOLLE Selenocysteine insertion sequence-binding protein 2-like HOLleu_19436 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) selenocysteine incorporation [GO:0001514] ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368] 1 0.7 0.99394 -0.068637 GPQVGPAA 24.1486 0 0 0 0 0 23.8929 21.0679 21.0679 25.4279 25.2761 25.2761 21.6283 21.6583 21.6583 0 0 0 A0A9Q1H7Z0 A0A9Q1H7Z0_HOLLE Hyalin HOLleu_20380 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1.3 1.0172 -22.715 VCSCTDNSQNTGRC 19.7867 21.3582 21.3582 0 0 0 0 0 0 0 20.3516 20.3516 0 0 0 0 0 0 A0A9Q1H838 A0A9Q1H838_HOLLE Fibulin-2 HOLleu_20585 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Golgi to vacuole transport [GO:0006896]; protein targeting to vacuole [GO:0006623] endosome [GO:0005768]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] calcium ion binding [GO:0005509] 1 1.4 1.0119 -6.0118 NIDCVEDGCVCD 0 24.5231 24.5231 0 20.8365 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H842 A0A9Q1H842_HOLLE CUGBP Elav-like family member 3 HOLleu_20014 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] 2 3.6 0.97486 -0.13727 DAELMSMF;YAAAAPDQ 19.4423 21.5829 21.5829 0 0 0 21.1033 0 0 21.3086 0 0 0 0 0 0 0 0 A0A9Q1H844 A0A9Q1H844_HOLLE Carboxylic ester hydrolase (EC 3.1.1.-) HOLleu_19907 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholinesterase activity [GO:0004104] 1 1.4 0.99383 -0.068637 YGDAGFNC 0 0 0 0 0 0 0 0 0 21.9804 0 0 0 0 0 0 0 0 A0A9Q1H848 A0A9Q1H848_HOLLE Tax1-binding protein 1-like HOLleu_20619 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.6 1.0195 -17.224 VHEKLTNDYEKSRMEC 0 0 0 0 0 0 18.7822 0 0 19.4422 0 0 0 0 0 0 0 0 A0A9Q1H852 A0A9Q1H852_HOLLE Uncharacterized protein HOLleu_19733 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0116 -23.777 CETMSDMF 0 0 0 0 0 0 0 0 0 0 0 0 19.5484 17.4514 17.4514 0 0 0 A0A9Q1H856 A0A9Q1H856_HOLLE Multiple epidermal growth factor-like domains protein 6 HOLleu_19752 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] scavenger receptor activity [GO:0005044] 3 1.8 0.99781 -29.295 FCTQPCQPG;PCDVGFYGPDCVYQCQ;PFGTYGAD 24.139 25.1659 25.1659 17.3128 15.6883 15.6883 0 0 0 24.8427 23.6662 23.6662 20.5557 0 0 0 0 0 A0A9Q1H865 A0A9Q1H865_HOLLE Uncharacterized protein HOLleu_19994 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5.7 1.0144 -5.5027 SCASDYYDEKCSTYCA 0 0 0 0 0 0 25.3848 25.975 25.975 0 0 0 0 0 0 0 0 0 A0A9Q1H891 A0A9Q1H891_HOLLE Cubilin HOLleu_17065 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 0.5 0.97514 -0.13727 NNNDDCEY;SYGNDANC 19.8457 20.5511 20.5511 0 0 0 0 24.0005 24.0005 27.043 15.7021 19.0453 0 0 0 0 0 0 A0A9Q1H8B4 A0A9Q1H8B4_HOLLE Carbohydrate sulfotransferase 1 HOLleu_20266 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790] trans-Golgi network [GO:0005802] N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517] 1 2.2 0.99363 -0.068637 EVEDMCDT 0 21.8548 21.8548 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H8B6 A0A9Q1H8B6_HOLLE Fibrillin-1 HOLleu_20192 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 3.2 1.0145 -6.0779 YWPDIDECAENTDN 0 21.9445 21.9445 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H8C9 A0A9Q1H8C9_HOLLE Fibropellin-1 HOLleu_19997 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 8.9 1.0149 -5.8824 QCDCVAGYSGLFCEEDLDECA 0 0 0 0 0 0 0 0 0 0 21.2831 21.2831 17.8943 18.4323 18.4323 0 0 0 A0A9Q1H8D0 A0A9Q1H8D0_HOLLE Uncharacterized protein HOLleu_17500 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 0.98077 -0.068637 VCPVLLVK 0 0 0 0 0 0 0 23.6701 23.6701 0 0 0 0 0 0 0 0 0 A0A9Q1H8E7 A0A9Q1H8E7_HOLLE Adhesion G-protein coupled receptor G4 HOLleu_20379 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 2 4.7 1.0032 -2.7921 DWPSDDGCMAVGNVTNDGYSN;PSDDGCMA 22.7502 21.2814 21.2814 0 0 0 22.5136 0 0 20.8938 20.4781 20.4781 0 0 0 15.988 0 16.9967 A0A9Q1H8G1 A0A9Q1H8G1_HOLLE Uncharacterized protein HOLleu_17618 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 8 0.99351 -0.068637 LFVSFKHR 18.977 21.627 21.627 0 0 0 0 0 0 22.7495 22.0865 22.0865 0 19.3456 19.3456 0 0 0 A0A9Q1H8H8 A0A9Q1H8H8_HOLLE Uncharacterized protein HOLleu_20157 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.2 1 -0.068637 GGTHMGGG 19.2284 21.5215 21.5215 0 19.1841 0 20.3776 0 19.8158 21.0112 21.2541 21.2541 16.7572 0 0 0 0 0 A0A9Q1H8I9 A0A9Q1H8I9_HOLLE Latent-transforming growth factor beta-binding protein 4 HOLleu_20529 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160] membrane [GO:0016020] calcium ion binding [GO:0005509] 2 0.5 1.0084 -6.318 CVCQYGFSEDEDG;TGMSAMTA 0 0 0 0 0 0 0 0 0 0 22.693 22.693 24.5616 0 0 0 0 0 A0A9Q1H8K2 A0A9Q1H8K2_HOLLE Latent-transforming growth factor beta-binding protein 4 HOLleu_20586 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 2 4.4 1.0037 -26.5 DQQCQDINECQELSSPCNDGD;EECQMMKC 0 18.8527 18.8527 0 0 0 0 0 0 22.8503 0 0 0 0 0 0 0 0 A0A9Q1H8L1 A0A9Q1H8L1_HOLLE Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) HOLleu_20620 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.4 1.0066 -0.068637 VAGQVPGP 0 0 0 20.7575 21.8114 21.8114 0 21.2579 21.2579 20.3788 0 0 0 17.8763 17.8763 18.4638 19.8813 19.8813 A0A9Q1H8M3 A0A9Q1H8M3_HOLLE Inactive tyrosine-protein kinase PEAK1 HOLleu_20658 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] protein kinase activity [GO:0004672] 1 0.5 0.98204 -0.068637 NSDMSSCS 0 20.749 20.749 0 0 0 0 0 0 19.558 19.0796 19.0796 0 0 0 0 0 0 A0A9Q1H8R8 A0A9Q1H8R8_HOLLE Macrophage mannose receptor 1 HOLleu_20811 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] signaling receptor activity [GO:0038023] 1 2.2 1.0093 -5.5027 GYCPQGWNESGNYCYM 0 21.8709 21.8709 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H8S5 A0A9Q1H8S5_HOLLE Uncharacterized protein HOLleu_18033 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] actin filament binding [GO:0051015]; small GTPase binding [GO:0031267] 1 0.9 0.94086 -0.068637 NGGPKMKA 0 0 0 0 0 0 0 0 0 21.1954 20.7586 20.7586 0 0 0 0 0 0 A0A9Q1H8S9 A0A9Q1H8S9_HOLLE CCHC-type domain-containing protein HOLleu_14217 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 5.6 1.0286 -23.631 KKRPGKPAHVK 0 0 0 0 0 0 0 19.8614 19.8614 0 0 0 0 0 0 0 0 0 A0A9Q1H8T8 A0A9Q1H8T8_HOLLE RING-type E3 ubiquitin transferase (EC 2.3.2.27) HOLleu_14254 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell cycle [GO:0007049]; protein ubiquitination [GO:0016567] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] 1 1 0.94595 -0.068637 IMCDECDM 19.5371 21.1117 21.1117 0 16.7366 0 0 0 0 22.5856 0 0 16.1594 0 0 0 0 0 A0A9Q1H8T9 A0A9Q1H8T9_HOLLE Tenascin-R HOLleu_17501 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.1 1.0165 -2.6427 YYYSYCNYW 0 0 0 15.8975 16.4312 16.4312 0 17.2615 17.2615 0 23.9255 23.9255 17.7151 0 0 0 0 0 A0A9Q1H8U7 A0A9Q1H8U7_HOLLE Uncharacterized protein HOLleu_14290 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 21.4 1.008 -2.7235 VCMYVYMYVCMCVCVCMCVCD 21.179 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H8V5 A0A9Q1H8V5_HOLLE Zinc finger and SCAN domain-containing protein 10 HOLleu_14329 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 1 1.2 1.0081 -2.6427 QENYCCSEN 0 0 0 0 0 0 0 0 0 23.1962 0 0 0 0 0 0 0 0 A0A9Q1H8X1 A0A9Q1H8X1_HOLLE Endonuclease HOLleu_17640 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] 2 2.4 1.0096 -10.943 DIHLLDYVSRFKDRFHGACE;YVEFAYQKERHFDRW 0 0 0 0 0 0 0 0 0 0 0 0 0 19.1493 19.1493 0 0 0 A0A9Q1H8X7 A0A9Q1H8X7_HOLLE Angiopoietin-1 receptor HOLleu_14425 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.7 1.015 -2.2078 PPDCEGVCESCYNGGICDENTGD 21.158 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H8Y2 A0A9Q1H8Y2_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_14441 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dephosphorylation [GO:0016311] membrane [GO:0016020]; receptor complex [GO:0043235] protein tyrosine phosphatase activity [GO:0004725] 1 0.5 0.94505 -0.068637 IWGGARDA 0 22.9157 22.9157 0 0 0 0 19.7005 0 0 0 0 20.0503 19.854 19.854 0 0 0 A0A9Q1H8Y3 A0A9Q1H8Y3_HOLLE PC4 and SFRS1-interacting protein HOLleu_20718 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] 3 3.1 1.0123 -11.758 KGRGKGKK;KSSGGKAK;PKKKKKKAKEKKKKKRRK 22.3741 22.9814 22.9814 21.9539 23.3088 23.3088 23.1479 22.6799 22.6799 24.6922 0 0 0 0 0 21.7486 22.9594 22.9594 A0A9Q1H906 A0A9Q1H906_HOLLE Histone H1.5 HOLleu_17814 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; structural constituent of chromatin [GO:0030527] 1 5 1.0163 -22.715 AAKKKSAAKKKKTT 25.254 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H914 A0A9Q1H914_HOLLE Nuclear protein localization protein 4-like HOLleu_17398 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] 1 1.7 1.0007 -4.979 PELGYIKEST 0 23.6532 23.6532 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H932 A0A9Q1H932_HOLLE Mitochondrial import receptor subunit TOM22 homolog HOLleu_18402 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular protein transport [GO:0006886] mitochondrial outer membrane [GO:0005741] 1 7.9 0.94382 -0.068637 PNAAGAGG 20.9557 22.2504 22.2504 0 0 0 19.1841 18.2375 18.2375 20.7193 20.0102 20.0102 16.6006 16.9583 16.9583 0 0 0 A0A9Q1H942 A0A9Q1H942_HOLLE Ataxin-2-like protein HOLleu_17954 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.1 1.014 -2.2078 AHEEDEDDESAYHTDLAKEYCHC 0 0 0 0 0 0 24.3414 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H946 A0A9Q1H946_HOLLE Solute carrier organic anion transporter family member 2A1 HOLleu_17829 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347] 2 2.8 1.0007 -28.61 NADCYCPSGY;PKLISFLFLLV 0 0 0 0 0 0 0 0 0 0 26.1897 26.1897 0 0 0 18.0813 0 0 A0A9Q1H957 A0A9Q1H957_HOLLE Nipped-B-like protein B HOLleu_17864 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 9.8 1.0109 -11.473 EEEEEEEEEEEEEDKEE;SDDDTREHSESSN 23.4561 24.3174 24.3174 0 0 0 25.1832 24.473 24.473 17.8056 25.2268 25.2268 23.4041 23.6254 23.6254 0 0 16.7412 A0A9Q1H982 A0A9Q1H982_HOLLE Leucine-rich repeats and immunoglobulin-like domains protein 2 HOLleu_18582 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 1 3 0.94886 -0.068637 SSSCKCSG 22.0721 22.7591 22.7591 0 0 0 0 0 0 0 0 0 0 16.3449 16.3449 0 0 0 A0A9Q1H9A4 A0A9Q1H9A4_HOLLE Arrestin domain-containing protein 4 HOLleu_14942 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ubiquitin-dependent endocytosis [GO:0070086] cytosol [GO:0005829]; plasma membrane [GO:0005886] protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625] 1 1.2 1 -4.979 RRKIHSKKPI 0 0 0 0 0 0 0 0 0 28.0398 0 0 0 0 0 0 0 0 A0A9Q1H9B9 A0A9Q1H9B9_HOLLE P53-induced death domain-containing protein 1 HOLleu_18685 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] 1 1.4 1.0124 -5.5027 TSSVQNLEPNFWEECN 0 0 0 0 0 0 21.1889 20.9295 20.9295 0 0 0 0 0 0 0 0 16.1884 A0A9Q1H9C5 A0A9Q1H9C5_HOLLE Cathepsin D HOLleu_15038 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] lysosome [GO:0005764] aspartic-type endopeptidase activity [GO:0004190] 1 2 1.0047 -23.777 SSYCSGGC 0 0 0 0 0 0 0 0 0 20.2454 19.8265 19.8265 0 0 0 0 0 0 A0A9Q1H9E7 A0A9Q1H9E7_HOLLE ATP-binding cassette sub-family A member 3 HOLleu_17904 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; lipid transporter activity [GO:0005319] 1 0.6 0.10526 -0.068637 GVNGYTNE 0 0 0 0 0 0 0 0 0 0 0 0 22.6935 0 0 0 0 0 A0A9Q1H9F2 A0A9Q1H9F2_HOLLE Nucleolar protein 12 HOLleu_18826 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleolus [GO:0005730] rRNA binding [GO:0019843] 1 5.5 1.0166 -6.0118 KEDDEEDEDDFG 0 0 0 0 0 0 0 0 0 0 0 0 25.4142 0 0 0 0 0 A0A9Q1H9H0 A0A9Q1H9H0_HOLLE Endonuclease/exonuclease/phosphatase domain-containing protein HOLleu_15214 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) catalytic activity [GO:0003824] 1 6.7 1.0149 -16.819 KPYCSERSLPFSYSSSF 20.0912 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H9I1 A0A9Q1H9I1_HOLLE Neurogenic locus Notch protein HOLleu_18016 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 7 2.3 0.99928 -41.57 CSCPEGFEGPTCGTETNPCDN;FTYTCQCPAG;ISCDFEPCQNGATC;SCQCPTGFSGNT;SYMCICPDGFEGTDCQIDINPCDSS;TQIVNPCDSDPCVNGGSC;YMCMCPDGFEGTDCQID 26.136 0 0 0 0 0 23.0677 0 0 26.0042 22.2694 22.2694 21.8298 0 0 0 0 0 A0A9Q1H9K1 A0A9Q1H9K1_HOLLE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 HOLleu_15383 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747] 1 6.3 0.97059 -0.068637 EYDLCEYE 0 21.5643 21.5643 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1H9M2 A0A9Q1H9M2_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_15485 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] carbohydrate binding [GO:0030246]; kinase activity [GO:0016301] 4 5.3 0.9989 -28.907 DPPCDDGF;MCESQPSCT;NLFCYGGNYGC;YGGNYGCSCGCGWKG 0 0 0 0 0 0 21.4747 21.9183 21.9183 0 22.1632 22.1632 20.7989 18.7015 18.7015 0 0 0 A0A9Q1H9M3 A0A9Q1H9M3_HOLLE Inactive rhomboid protein 1 HOLleu_18667 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of protein secretion [GO:0050708] endoplasmic reticulum membrane [GO:0005789] serine-type endopeptidase activity [GO:0004252] 1 0.9 0.91787 -0.068637 SWCHYFNC 17.9684 0 0 0 0 0 0 0 0 21.9056 0 0 19.5564 19.9186 19.9186 0 0 0 A0A9Q1H9Q1 A0A9Q1H9Q1_HOLLE Uncharacterized protein HOLleu_15549 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 1.0039 -23.777 RKVSDWLD 0 0 0 0 0 0 0 0 0 0 0 0 17.6323 0 0 0 0 0 A0A9Q1H9T6 A0A9Q1H9T6_HOLLE Neurogenic locus notch-like protein 1 HOLleu_18631 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495] 10 6.7 0.99716 -61.993 ACESNPCGGNATCNNFCSYYTCSCP;AQCLQDPNSCTDYTCKC;CDVYSHPCSSQPCQNDGL;CTEFNCQCPKCWQGSLCTE;DCLSHTCECTE;EDETCSSFTCTCNGCWTGDT;FCEREIDPCQSNPCD;FCSYYTCSCPNCLTGETC;TCTCNGCWT;TNPDDCSSFTCQCP 24.4398 24.0031 24.0031 0 0 0 20.6738 18.3659 18.3659 25.0112 24.9382 24.9382 0 0 0 0 0 0 A0A9Q1H9X4 A0A9Q1H9X4_HOLLE "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3" HOLleu_15836 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ganglioside biosynthetic process [GO:0001574]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]" 1 1.7 1.0156 -2.6427 DECEYYQSM 0 0 0 0 0 0 0 0 0 20.6741 0 0 0 0 0 0 0 0 A0A9Q1H9Y5 A0A9Q1H9Y5_HOLLE Serine/threonine-protein kinase LMTK2 HOLleu_18548 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] 1 0.7 0.86691 -0.068637 LEQTGAGG 0 0 0 0 0 0 0 0 0 22.8525 0 0 0 0 0 0 0 0 A0A9Q1HA12 A0A9Q1HA12_HOLLE Hyalin HOLleu_12316 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] GTP binding [GO:0005525] 1 0.3 1.0256 -23.675 EINSDHEDCD 0 19.3475 19.3475 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HA24 A0A9Q1HA24_HOLLE Macrophage mannose receptor 1 HOLleu_12354 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 2.1 1.0224 -5.5496 FDESCEDNSGY 20.9769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HA28 A0A9Q1HA28_HOLLE Metalloendopeptidase (EC 3.4.24.-) HOLleu_12376 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] 1 3.2 1.0053 -5.3628 AQAGQCEEYEHWMNFNCPKSCNM 0 0 0 0 0 0 0 22.5667 22.5667 0 0 0 0 0 0 0 0 0 A0A9Q1HA52 A0A9Q1HA52_HOLLE Uncharacterized protein HOLleu_12474 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.7 1.0031 -23.777 VQEDSDDD 0 0 0 0 0 0 0 0 0 18.598 0 0 0 0 0 0 0 0 A0A9Q1HAA3 A0A9Q1HAA3_HOLLE Interferon-induced protein with tetratricopeptide repeats 5 HOLleu_18957 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) defense response to virus [GO:0051607] cytosol [GO:0005829] 1 2.9 1.0088 -6.0779 AEEFFKEADNENEN 25.6935 25.2159 25.2159 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HAA7 A0A9Q1HAA7_HOLLE Solute carrier family 35 member G1 HOLleu_15637 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 5.2 0.99745 -29.326 PTQYIGALFAF;VFVSILKT 22.1632 17.9621 17.9621 19.8055 0 0 0 0 0 17.0678 0 0 20.6244 20.0367 20.0367 0 0 0 A0A9Q1HAB9 A0A9Q1HAB9_HOLLE Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) HOLleu_15674 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 7-methylguanosine mRNA capping [GO:0006370]; cap1 mRNA methylation [GO:0097309]; cap2 mRNA methylation [GO:0097310] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483] 1 1.1 1.0035 -23.777 GWYFGVDN 0 0 0 0 0 0 0 0 0 0 23.5617 23.5617 0 0 0 0 0 0 A0A9Q1HAC8 A0A9Q1HAC8_HOLLE Neurogenic locus notch-like protein 1 HOLleu_19047 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 4 2.1 1.0208 -19.338 CSSNPCLNGATCENLQNEYNCIC;IDECDSDPCFNGGTCT;NSDPCQNGATC;TCQCVNGWAGTTCQ 24.0342 24.9453 24.9453 0 0 0 0 22.2198 22.2198 24.5681 23.6724 23.6724 0 0 0 0 0 0 A0A9Q1HAG4 A0A9Q1HAG4_HOLLE MIF4G domain-containing protein HOLleu_12895 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of translation [GO:0045727]; regulation of formation of translation initiation ternary complex [GO:1901190] cytoplasm [GO:0005737]; RNA cap binding complex [GO:0034518] eukaryotic initiation factor 4E binding [GO:0008190]; translation initiation factor activity [GO:0003743] 1 2.6 1.0294 -23.442 STDDDSDESYDD 0 0 0 0 0 0 0 0 0 0 18.5782 18.5782 17.3479 16.9898 16.9898 0 0 0 A0A9Q1HAH5 A0A9Q1HAH5_HOLLE Lipase member I HOLleu_16540 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) lipid catabolic process [GO:0016042] extracellular space [GO:0005615] lipase activity [GO:0016298] 1 2.5 0.7381 -0.068637 QTNGNSPY 0 0 0 0 0 0 0 25.5814 25.5814 0 0 0 0 0 0 0 0 0 A0A9Q1HAL2 A0A9Q1HAL2_HOLLE ribonuclease III (EC 3.1.26.3) HOLleu_16420 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; rRNA processing [GO:0006364]; termination of RNA polymerase II transcription [GO:0006369]; U4 snRNA 3'-end processing [GO:0034475] microprocessor complex [GO:0070877]; nucleoplasm [GO:0005654] double-stranded RNA binding [GO:0003725]; ribonuclease III activity [GO:0004525] 1 0.8 1.0269 -23.027 HQSDESSSSDSDS 0 0 0 0 19.2643 19.2643 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HAN1 A0A9Q1HAN1_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_13156 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endocytosis [GO:0006897]; proteolysis [GO:0006508] membrane [GO:0016020] serine-type peptidase activity [GO:0008236] 1 0.5 1.0165 -2.6427 NADESNENC 20.2251 21.9816 21.9816 0 0 0 0 0 0 16.6527 15.8698 15.8698 0 0 0 0 0 0 A0A9Q1HAP3 A0A9Q1HAP3_HOLLE Mechanosensory protein 2 HOLleu_16797 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 2 5.7 1.0041 -25.951 PGPAKGPG;QRAMAAEA 0 0 0 21.4433 17.7729 17.7729 17.7881 0 0 0 19.7345 19.7345 0 0 0 18.7469 0 19.4543 A0A9Q1HAP4 A0A9Q1HAP4_HOLLE Adenylate kinase isoenzyme 5 HOLleu_15838 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] cytoplasm [GO:0005737] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550] 1 1 1.0266 -23.631 SETSGRADDTG 0 0 0 0 0 0 19.0597 0 0 0 0 0 0 18.5122 18.5122 0 0 0 A0A9Q1HAQ8 A0A9Q1HAQ8_HOLLE Iron-sulfur protein NUBPL HOLleu_16616 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) iron-sulfur cluster assembly [GO:0016226]; mitochondrial respiratory chain complex I assembly [GO:0032981] cytosol [GO:0005829]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; metal ion binding [GO:0046872]" 1 3 0.87313 -0.068637 KPIPGVKN 21.8961 23.2724 23.2724 0 18.4543 18.4543 0 18.9799 18.9799 0 22.4206 22.4206 19.8973 0 0 0 0 0 A0A9Q1HAU0 A0A9Q1HAU0_HOLLE Nuclear pore complex protein Nup214 HOLleu_16758 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405] nuclear pore [GO:0005643] nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] 2 0.9 1 -47.219 LNCDEQILSVVL;SGGFGGFA 0 20.6621 20.6621 0 0 0 20.2928 0 0 22.0032 0 0 0 0 0 0 0 0 A0A9Q1HAW0 A0A9Q1HAW0_HOLLE Collagen alpha-1(XXVII) chain B HOLleu_16076 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] 1 0.7 1.0067 -23.777 MGPPGSDG 0 20.6877 20.6877 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HAW9 A0A9Q1HAW9_HOLLE Endonuclease HOLleu_16398 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA integration [GO:0015074]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; RNA-directed DNA polymerase activity [GO:0003964] 1 0.5 1.0039 -23.777 LKPIHQLA 0 0 0 0 0 0 19.1414 18.7648 18.7648 0 0 0 0 0 0 0 0 0 A0A9Q1HAX2 A0A9Q1HAX2_HOLLE Uncharacterized protein HOLleu_16122 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.9 0.87266 -0.068637 VIHLIFLA 18.4725 21.3952 21.3952 20.4229 0 0 21.3551 21.5201 21.5201 24.875 0 0 0 20.7132 20.7132 18.6824 0 0 A0A9Q1HAX9 A0A9Q1HAX9_HOLLE Dermatan-sulfate epimerase-like protein HOLleu_13559 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate metabolic process [GO:0030205] membrane [GO:0016020] chondroitin-glucuronate 5-epimerase activity [GO:0047757]; sulfotransferase activity [GO:0008146] 1 0.8 1.0021 -4.979 MCPACFCCFQ 0 21.8123 21.8123 0 0 0 0 0 0 0 0 0 19.3562 0 0 0 0 0 A0A9Q1HB01 A0A9Q1HB01_HOLLE Solute carrier family 23 member 2 HOLleu_17192 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) organic substance transport [GO:0071702] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] 1 1.4 0.86695 -0.068637 GVAMEGLG 0 22.5879 22.5879 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HB02 A0A9Q1HB02_HOLLE Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 HOLleu_16987 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) catalytic step 2 spliceosome [GO:0071013] ATP binding [GO:0005524]; helicase activity [GO:0004386]; RNA binding [GO:0003723] 1 0.8 1.0059 -23.777 RKDIKYKK 0 0 0 0 0 0 20.4171 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HB37 A0A9Q1HB37_HOLLE GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) HOLleu_16360 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) fucose metabolic process [GO:0006004]; Notch signaling pathway [GO:0007219] peptide-O-fucosyltransferase activity [GO:0046922] 1 2 0.86219 -0.068637 LAFAGAPA 0 25.7637 25.7637 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HBB0 A0A9Q1HBB0_HOLLE Protein SET HOLleu_16599 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] 1 7.5 1.006 -5.3628 EPGQDDEGDEEDDEDDDEEEDPE 0 0 0 0 0 0 0 0 0 20.0867 0 0 0 0 0 0 0 0 A0A9Q1HBC6 A0A9Q1HBC6_HOLLE Anaphase-promoting complex subunit 2 HOLleu_16890 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein K11-linked ubiquitination [GO:0070979]; ubiquitin-dependent protein catabolic process [GO:0006511] anaphase-promoting complex [GO:0005680] ubiquitin protein ligase binding [GO:0031625] 1 1.3 1.0167 -22.715 IQEGQGSDDCEEEG 0 0 0 0 0 0 0 0 0 18.3705 19.5585 19.5585 0 0 0 0 0 0 A0A9Q1HBE1 A0A9Q1HBE1_HOLLE protein-tyrosine-phosphatase (EC 3.1.3.48) HOLleu_13926 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; dephosphorylation [GO:0016311] membrane [GO:0016020]; receptor complex [GO:0043235] protein tyrosine phosphatase activity [GO:0004725] 1 0.4 0.86333 -0.068637 LIKHLQCL 0 25.7128 25.7128 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HBF7 A0A9Q1HBF7_HOLLE TBC1 domain family member 2B HOLleu_16985 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) centrosome [GO:0005813] 1 0.9 1.0285 -23.442 PKIKAPRVLDKL 0 0 0 0 0 0 0 0 0 0 23.8177 23.8177 0 0 0 0 0 0 A0A9Q1HBG3 A0A9Q1HBG3_HOLLE RING-type E3 ubiquitin transferase (EC 2.3.2.27) HOLleu_14107 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] 2 1.7 1.0108 -7.6217 GMPCDEDEN;GMPCDEDENH 20.5027 22.4037 22.4037 0 0 0 0 0 0 24.1901 0 0 0 0 0 0 0 0 A0A9Q1HBH3 A0A9Q1HBH3_HOLLE Reverse transcriptase domain-containing protein HOLleu_14143 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.7 1.014 -6.0118 KIDKVLTRLKKF 23.057 24.7168 24.7168 23.3623 0 0 0 24.2222 24.2222 26.8478 27.7537 27.7537 24.9686 25.197 25.197 0 0 0 A0A9Q1HBJ6 A0A9Q1HBJ6_HOLLE CUB and sushi domain-containing protein 3 HOLleu_16894 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.4 1.028 -23.631 SFAMYTCNSGY 0 19.8819 19.8819 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HBJ7 A0A9Q1HBJ7_HOLLE Receptor-type tyrosine-protein phosphatase alpha HOLleu_14238 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 4 3.5 1.0204 -17.403 CGANTFGYNCEFKCDY;GCCHRQWIETNNHAC;LEECHCESEACDKA;QECHCDDD 23.1082 22.1261 22.1261 0 0 0 18.1529 24.2396 24.2396 0 22.5003 22.5003 0 0 0 0 0 0 A0A9Q1HBK9 A0A9Q1HBK9_HOLLE Zinc finger CCCH-type with G patch domain-containing protein HOLleu_17213 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.5 0.87121 -0.068637 YDDDSDDD 0 0 0 0 0 0 0 0 0 21.5991 21.1726 21.1726 0 0 0 0 0 0 A0A9Q1HBM8 A0A9Q1HBM8_HOLLE Leucine-rich repeat-containing G-protein coupled receptor 5 HOLleu_10346 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] 1 1.2 1.0285 -23.442 YITLNILRIFFR 0 0 0 0 0 0 0 0 0 20.1397 0 0 0 0 0 0 0 0 A0A9Q1HBQ4 A0A9Q1HBQ4_HOLLE Atrial natriuretic peptide-converting enzyme HOLleu_10453 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] 1 1.8 1.0007 -4.979 HQVCDHEWDC 0 22.0174 22.0174 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HBQ5 A0A9Q1HBQ5_HOLLE Nipped-B-like protein B HOLleu_13662 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 18.7 1.0073 -5.3628 AAEEKGKKKERKKERKKERKKER 17.6984 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HBR4 A0A9Q1HBR4_HOLLE 18S rRNA (Guanine-N(7))-methyltransferase HOLleu_10502 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) rRNA (guanine-N7)-methylation [GO:0070476] cytoplasm [GO:0005737]; nucleolus [GO:0005730] rRNA (guanine) methyltransferase activity [GO:0016435] 1 3.2 1.0256 -23.675 LNFIRLFRLI 0 22.2167 22.2167 0 0 0 20.5469 0 0 22.714 22.6156 22.6156 0 20.5259 20.5259 0 0 0 A0A9Q1HBS8 A0A9Q1HBS8_HOLLE Centromere protein C HOLleu_14479 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; kinetochore assembly [GO:0051382]; spindle attachment to meiosis I kinetochore [GO:0051455] kinetochore [GO:0000776]; nucleus [GO:0005634] centromeric DNA binding [GO:0019237] 1 0.7 1.0252 -23.631 GIRRSKRNRVR 0 0 0 0 0 0 0 0 0 0 0 0 19.6863 18.507 18.507 0 0 0 A0A9Q1HBV0 A0A9Q1HBV0_HOLLE Uncharacterized protein HOLleu_14612 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 6.7 0.9968 -51.148 AEDNDDEDEM;EEEHEEEDPNE;PDSEEEEHEEEDPNE 16.2063 17.3857 17.3857 0 0 0 0 0 0 18.8658 25.0035 25.0035 0 0 0 0 0 0 A0A9Q1HBW1 A0A9Q1HBW1_HOLLE Neurogenic locus Notch protein HOLleu_17351 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cellular response to stimulus [GO:0051716]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 1.6 1.0036 -2.5328 YSCHCTHGYFGATCESEKDECS 0 0 0 0 0 0 0 0 0 24.016 0 0 0 0 0 0 0 0 A0A9Q1HC07 A0A9Q1HC07_HOLLE Tenascin-X HOLleu_14828 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 12.2 1.0007 -4.979 SDHDDEPDYN 0 0 0 0 0 0 0 0 0 0 26.1897 26.1897 0 0 0 0 0 0 A0A9Q1HC32 A0A9Q1HC32_HOLLE E3 ubiquitin-protein ligase TRIM56 HOLleu_14920 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 1.7 0.86842 -0.068637 SKCCDNCN 0 0 0 0 0 0 0 0 0 0 20.8443 20.8443 0 0 0 0 0 0 A0A9Q1HC97 A0A9Q1HC97_HOLLE Calreticulin HOLleu_14187 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein folding [GO:0006457]; response to stimulus [GO:0050896] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789] calcium ion binding [GO:0005509]; unfolded protein binding [GO:0051082] 4 8 1.0101 -10.432 DDEMDGEWE;DFEDYEDDELFDEGEFDEEDEG;EDFEDYEDDELFDEGEFDEED;FEDYEDDELFDEGEFDEEDEGD 23.8328 25.6201 25.6201 0 0 0 0 0 0 0 26.9456 26.9456 21.566 0 0 0 0 0 A0A9Q1HCB1 A0A9Q1HCB1_HOLLE VWFA and cache domain-containing protein 1 HOLleu_15199 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] 2 1.8 0.99672 -29.428 LKPSIKKHVA;MEGNEDDDQNGPPGG 0 0 0 17.212 18.5056 18.5056 22.4649 21.8714 21.8714 0 0 0 0 0 0 16.4097 0 17.3915 A0A9Q1HCD0 A0A9Q1HCD0_HOLLE Nuclear factor interleukin-3-regulated protein HOLleu_14295 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) circadian rhythm [GO:0007623] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] 1 1.5 0.86792 -0.068637 SAEGGEYE 0 0 0 0 0 0 0 0 0 22.0311 21.5703 21.5703 0 0 0 0 0 0 A0A9Q1HCE3 A0A9Q1HCE3_HOLLE H/ACA ribonucleoprotein complex non-core subunit NAF1 HOLleu_15325 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) box H/ACA snoRNP assembly [GO:0000493]; pseudouridine synthesis [GO:0001522]; ribosome biogenesis [GO:0042254] nucleus [GO:0005634]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] RNA binding [GO:0003723] 1 1.1 1.0124 -23.777 DGDGDCEQ 0 0 0 0 0 0 0 0 0 21.1465 0 0 0 0 0 0 0 0 A0A9Q1HCE9 A0A9Q1HCE9_HOLLE JmjC domain-containing histone demethylation protein 1 (EC 1.14.11.27) ([Histone-H3]-lysine-36 demethylase 1) HOLleu_11592 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] 1 1.5 1.0071 -6.2493 MNSDCGECHFCKD 0 0 0 0 0 0 0 0 0 0 0 0 23.5087 22.8505 22.8505 0 0 0 A0A9Q1HCF3 A0A9Q1HCF3_HOLLE Deleted in malignant brain tumors 1 protein HOLleu_15370 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) zymogen activation [GO:0031638] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] 2 1.3 1.0084 -6.318 CDDEWALVDGNVV;YETSIFNC 20.9088 25.6366 25.6366 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HCF7 A0A9Q1HCF7_HOLLE Receptor-type tyrosine-protein phosphatase kappa HOLleu_14557 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] 2 3.6 1.019 -1.502 DRLEEYSGVYINIKNKRKIV;LIAVIVVFVIIRRKISSKDKKATKA 0 23.1322 23.1322 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HCH9 A0A9Q1HCH9_HOLLE Neurotrypsin HOLleu_15473 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] chitin binding [GO:0008061] 2 1.7 0.99854 -29 EHCECEGC;NTPEHCECEGCVDYRDS 19.9873 0 0 0 0 0 23.0344 21.9014 21.9014 0 0 0 0 0 0 0 0 0 A0A9Q1HCJ1 A0A9Q1HCJ1_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_14671 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] 1 0.6 1.0043 -23.777 RPLSIDES 0 0 0 0 0 0 0 0 0 0 0 0 20.3679 0 0 0 0 0 A0A9Q1HCJ9 A0A9Q1HCJ9_HOLLE Galaxin HOLleu_07098 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.5 1.0145 -6.0779 CCDGYVIEATWTCC 0 22.9576 22.9576 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HCL7 A0A9Q1HCL7_HOLLE WD repeat-containing protein 36 HOLleu_14597 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) rRNA processing [GO:0006364] Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] 1 1.1 1 -4.979 FQITCMMHPS 0 0 0 0 0 0 0 0 0 0 22.5519 22.5519 0 20.0943 20.0943 0 0 0 A0A9Q1HCN3 A0A9Q1HCN3_HOLLE HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HOLleu_14811 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] ligase activity [GO:0016874]; ubiquitin protein ligase activity [GO:0061630] 1 1.4 1.0173 -21.924 KDKDILRTRLLYAIE 0 0 0 0 0 0 0 0 0 21.0006 0 0 0 0 0 0 0 0 A0A9Q1HCP0 A0A9Q1HCP0_HOLLE Fibrinogen C domain-containing protein 1 HOLleu_14827 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] 2 8.9 1.0193 -23.743 CTQQCNCS;NCVSPSECSC 0 23.3127 23.3127 0 0 0 20.5531 20.594 20.594 22.5669 0 0 0 0 0 0 0 0 A0A9Q1HCQ7 A0A9Q1HCQ7_HOLLE Probable RNA polymerase II nuclear localization protein SLC7A6OS HOLleu_12079 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) developmental process [GO:0032502]; protein transport [GO:0015031] cytoplasm [GO:0005737]; nucleus [GO:0005634] 1 4 1.0093 -6.0779 YDLYYTDCSEFDFG 0 24.2472 24.2472 0 0 0 0 0 0 0 23.1213 23.1213 0 0 0 0 0 0 A0A9Q1HCS0 A0A9Q1HCS0_HOLLE E3 ubiquitin-protein ligase TRIM56 HOLleu_14919 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 2 4.7 1.0036 -8.7206 HPQNTASHC;YCFICDGYLCDNCH 0 24.6037 24.6037 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HCS4 A0A9Q1HCS4_HOLLE RNA exonuclease 1-like HOLleu_14793 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] 1 0.9 1.0111 -6.0779 VDLDQSSNCSDEEF 0 0 0 0 0 0 0 0 0 23.5812 0 0 20.0671 0 0 0 0 0 A0A9Q1HCT5 A0A9Q1HCT5_HOLLE Leishmanolysin-like peptidase (EC 3.4.24.-) HOLleu_07460 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion [GO:0007155]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 1.9 1.0208 -21.924 QDSSEFFCNSSWSGC 19.879 21.2029 21.2029 0 0 0 0 0 0 21.3136 20.8092 20.8092 0 0 0 0 0 0 A0A9Q1HCV9 A0A9Q1HCV9_HOLLE adenylate cyclase (EC 4.6.1.1) HOLleu_12187 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] 1 0.7 0.85294 -0.068637 MGLDMCEA 0 0 0 0 0 0 0 0 0 22.5336 0 0 20.6223 0 0 0 0 0 A0A9Q1HCY1 A0A9Q1HCY1_HOLLE Dihydroxyacetone phosphate acyltransferase HOLleu_07680 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; phospholipid biosynthetic process [GO:0008654]; triglyceride biosynthetic process [GO:0019432] mitochondrial membrane [GO:0031966]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; glycerone-phosphate O-acyltransferase activity [GO:0016287] 1 1.9 1.0027 -6.2493 LYKRLLRHLYVNR 0 0 0 0 19.877 19.877 0 20.9659 20.9659 0 0 0 0 0 0 0 0 0 A0A9Q1HD04 A0A9Q1HD04_HOLLE Uncharacterized protein HOLleu_07778 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.2 0.87069 -0.068637 KIPFKKRF 20.9394 21.9704 21.9704 17.609 18.806 18.806 19.4961 20.5832 20.5832 22.8475 22.5245 22.5245 17.8845 18.286 18.286 0 0 0 A0A9Q1HD22 A0A9Q1HD22_HOLLE Nuclear export mediator factor Nemf HOLleu_07857 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytoplasm [GO:0005737]; RQC complex [GO:1990112] ribosomal large subunit binding [GO:0043023]; tRNA binding [GO:0000049] 1 1.2 1.0157 -6.0779 KNAVDEGLSEDEMT 0 0 0 0 0 0 0 21.4315 21.4315 0 0 0 0 0 0 0 0 0 A0A9Q1HD28 A0A9Q1HD28_HOLLE Neuralized-like protein 2 HOLleu_12462 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630] 1 3 1.0193 -23.723 NILPLHFLV 0 0 0 0 0 0 19.147 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HD42 A0A9Q1HD42_HOLLE Secreted protein HOLleu_12513 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.8 0.84298 -0.068637 PMKRKGGG 24.1665 23.4376 23.4376 0 0 0 22.2562 0 0 23.2757 22.6247 22.6247 22.9056 22.721 22.721 0 0 0 A0A9Q1HD48 A0A9Q1HD48_HOLLE DNA 3'-5' helicase (EC 5.6.2.4) HOLleu_12680 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; four-way junction helicase activity [GO:0009378]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] 1 0.7 1.0257 -23.675 LPKKKTGRKK 0 0 0 0 17.2889 17.2889 0 17.819 17.819 0 0 0 0 0 0 0 0 0 A0A9Q1HD75 A0A9Q1HD75_HOLLE Ciliary neurotrophic factor receptor subunit alpha HOLleu_15328 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] 2 2.7 0.99702 -4.6327 NGDEDKFDENDCPFDDDDS;PGIIEATT 23.9868 25.2743 25.2743 16.7273 0 0 0 0 0 0 0 0 17.0055 0 0 0 0 0 A0A9Q1HD76 A0A9Q1HD76_HOLLE Sodium-coupled monocarboxylate transporter 2 HOLleu_15486 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sodium ion transport [GO:0006814] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] symporter activity [GO:0015293] 1 3.8 0.98598 -0.20876 IVPAAIIINNGYLPIFFRLKLNNV 0 0 0 0 0 0 0 0 0 0 0 0 19.2871 19.0663 19.0663 0 0 0 A0A9Q1HD78 A0A9Q1HD78_HOLLE Transmembrane protein 143 HOLleu_12648 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.3 1.0114 -6.0118 FYNSYKNRRVKY 20.9738 22.5593 22.5593 0 17.0804 17.0804 0 0 0 0 0 0 17.6207 18.0229 18.0229 0 0 0 A0A9Q1HD87 A0A9Q1HD87_HOLLE G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75) HOLleu_08107 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) kinetochore [GO:0000776] nucleic acid binding [GO:0003676] 1 5.3 1.0163 -5.7538 HYCVWCGTSYEDAED 0 21.4999 21.4999 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HD98 A0A9Q1HD98_HOLLE Fibropellin-1 HOLleu_12861 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576] biotin binding [GO:0009374] 1 4.6 1.0014 -4.979 FSYGAAGDGP 0 0 0 0 18.509 0 0 22.9781 22.9781 0 0 0 0 0 0 0 0 0 A0A9Q1HDB0 A0A9Q1HDB0_HOLLE Protein arginine N-methyltransferase (EC 2.1.1.-) HOLleu_12754 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] protein-arginine omega-N monomethyltransferase activity [GO:0035241] 1 1.1 0.87356 -0.068637 ESMADCSG 0 0 0 0 0 0 0 0 0 0 0 0 0 21.779 21.779 0 0 0 A0A9Q1HDB2 A0A9Q1HDB2_HOLLE Uncharacterized protein HOLleu_08201 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] nuclear pore outer ring [GO:0031080] ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056] 1 0.8 1.0244 -23.675 VSKKKTLLSL 20.9758 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HDC0 A0A9Q1HDC0_HOLLE Non-canonical poly(A) RNA polymerase PAPD5 HOLleu_12787 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) RNA 3'-end processing [GO:0031123] nucleolus [GO:0005730]; TRAMP complex [GO:0031499] mRNA binding [GO:0003729]; poly(A) RNA polymerase activity [GO:1990817] 2 3.5 1.006 -24.345 PRPEEHVMRQEVVRR;QVPSPSSSSSG 0 0 0 0 0 0 0 0 0 18.99 18.3212 18.3212 0 0 0 0 0 0 A0A9Q1HDC2 A0A9Q1HDC2_HOLLE Glutathione synthetase (GSH-S) (EC 6.3.2.3) HOLleu_11878 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytosol [GO:0005829] ATP binding [GO:0005524]; glutathione binding [GO:0043295]; glutathione synthase activity [GO:0004363]; magnesium ion binding [GO:0000287] 1 1.6 0.87597 -0.068637 PTVKLRRR 0 0 0 0 0 0 0 21.9166 21.9166 0 0 0 0 0 0 0 0 0 A0A9Q1HDC4 A0A9Q1HDC4_HOLLE Crossover junction endonuclease MUS81 (EC 3.1.22.-) HOLleu_08243 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA catabolic process [GO:0006308]; double-strand break repair via break-induced replication [GO:0000727]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; resolution of meiotic recombination intermediates [GO:0000712] Holliday junction resolvase complex [GO:0048476]; nucleus [GO:0005634] 3'-flap endonuclease activity [GO:0048257]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] 1 1 1.0146 -23.777 GCHGDDDN 0 0 0 0 0 0 0 18.7339 18.7339 0 0 0 0 0 0 0 0 0 A0A9Q1HDC5 A0A9Q1HDC5_HOLLE Teashirt-like 1 HOLleu_12976 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 1.0094 -6.0779 SDSHAGGTDQENCF 0 25.5507 25.5507 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HDC9 A0A9Q1HDC9_HOLLE Solute carrier organic anion transporter family member HOLleu_08259 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347] 1 2.1 1.0162 -5.7538 DLTSQCNEHCGCSVQ 0 0 0 0 0 0 0 0 0 0 23.57 23.57 0 0 0 0 0 0 A0A9Q1HDF4 A0A9Q1HDF4_HOLLE Protein CBFA2T1 HOLleu_11984 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] 1 1.5 1.026 -23.675 FCQHKDWENH 0 0 0 0 0 0 18.8379 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HDG7 A0A9Q1HDG7_HOLLE Protein NDRG3 HOLleu_11916 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signal transduction [GO:0007165] cytoplasm [GO:0005737] 1 2.1 0.86328 -0.068637 GFGMGAGA 0 19.3478 19.3478 0 0 0 0 0 0 22.2962 0 0 0 18.202 18.202 0 0 0 A0A9Q1HDH5 A0A9Q1HDH5_HOLLE C2H2-type domain-containing protein HOLleu_12978 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 1 1.6 1.0164 -6.0779 HAGKNMYMCKDCEF 0 0 0 0 0 0 22.5428 21.9276 21.9276 0 0 0 0 0 0 0 0 0 A0A9Q1HDI2 A0A9Q1HDI2_HOLLE Uncharacterized protein HOLleu_12994 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.8 0.86275 -0.068637 GWMEGWME 20.9694 0 0 0 0 0 0 0 0 0 20.5032 20.5032 0 0 0 0 0 0 A0A9Q1HDI5 A0A9Q1HDI5_HOLLE Adhesion G protein-coupled receptor L3 HOLleu_12113 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] 1 0.4 0.75 -0.068637 MKNFDEYS 21.5705 0 0 0 0 0 0 0 0 21.3489 20.8832 20.8832 0 0 0 0 0 0 A0A9Q1HDK9 A0A9Q1HDK9_HOLLE G-protein coupled receptor 158 HOLleu_13093 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.2 0.86813 -0.068637 PYFDCGGG 0 22.7591 22.7591 0 17.7853 17.7853 0 0 0 23.0589 21.6316 21.6316 0 0 0 0 0 0 A0A9Q1HDL5 A0A9Q1HDL5_HOLLE NFX1-type zinc finger-containing protein 1 HOLleu_13109 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulatory ncRNA-mediated heterochromatin formation [GO:0031048] nuclear RNA-directed RNA polymerase complex [GO:0031380] helicase activity [GO:0004386]; zinc ion binding [GO:0008270] 2 1.4 0.9971 -30.026 DHVCQGTCGECKN;RYDNVHHY 0 0 0 0 18.0426 18.0426 0 17.8447 17.8447 0 0 0 0 21.3668 21.3668 0 0 0 A0A9Q1HDM8 A0A9Q1HDM8_HOLLE UPF0547 protein C16orf87-like HOLleu_12155 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.2 1.0199 -2.1738 RPKGMGKG 0 0 0 18.5224 18.154 18.154 0 0 0 0 0 0 0 0 0 18.5861 0 17.7211 A0A9Q1HDQ3 A0A9Q1HDQ3_HOLLE Low-density lipoprotein receptor-related protein 12 HOLleu_13452 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 3 6 1.0107 -14.285 CNGYNECGDDS;ESWMCDVQIDCTDGSDEENCP;MGCQDRCNGDMR 0 20.9734 20.9734 0 0 0 0 0 0 21.725 21.0479 21.0479 0 0 0 0 0 0 A0A9Q1HDQ6 A0A9Q1HDQ6_HOLLE FACT complex subunit HOLleu_13232 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) DNA repair [GO:0006281]; DNA replication [GO:0006260]; transcription elongation by RNA polymerase II [GO:0006368] FACT complex [GO:0035101] nucleosome binding [GO:0031491] 1 1.2 1.0255 -23.442 EESGKDWDELEK 22.3708 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HDR2 A0A9Q1HDR2_HOLLE Protein VAC14 homolog HOLleu_13249 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphatidylinositol biosynthetic process [GO:0006661] endosome membrane [GO:0010008]; PAS complex [GO:0070772] 1 2.5 1.0252 -23.631 PKLIFQHMDDI 0 0 0 17.7673 0 0 0 0 0 0 0 0 18.2597 0 0 0 0 0 A0A9Q1HDT8 A0A9Q1HDT8_HOLLE PQ-loop repeat-containing protein 1 HOLleu_13320 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "phospholipid translocation [GO:0045332]; retrograde transport, endosome to Golgi [GO:0042147]" endosome [GO:0005768]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] 1 3.3 1 -4.979 WGASCCMMFG 0 26.8496 26.8496 0 0 0 0 0 0 26.9106 0 0 0 0 0 0 0 0 A0A9Q1HDV2 A0A9Q1HDV2_HOLLE Nesprin-1 HOLleu_09009 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; nuclear envelope [GO:0005635] 1 0.6 1.009 -2.6427 DDEYCCEFV 21.4346 22.0498 22.0498 0 15.3569 15.3569 0 0 0 21.7887 20.7876 20.7876 0 0 0 0 0 0 A0A9Q1HDV9 A0A9Q1HDV9_HOLLE ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) HOLleu_13390 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] centrosome [GO:0005813]; cilium [GO:0005929]; mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634] 1 4.3 0.85771 -0.068637 HHFDDDEE 20.9562 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HDX3 A0A9Q1HDX3_HOLLE Anillin HOLleu_12573 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) actomyosin contractile ring assembly [GO:0000915]; mitotic cytokinesis [GO:0000281]; septin ring organization [GO:0031106] actomyosin contractile ring [GO:0005826] 1 0.9 1.0027 -4.979 IVPQKRKAPL 0 24.0892 24.0892 0 19.4321 19.4321 22.5007 24.5125 24.5125 23.4948 0 0 0 0 0 0 0 0 A0A9Q1HDZ6 A0A9Q1HDZ6_HOLLE Uncharacterized protein HOLleu_12576 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.1 0.84615 -0.068637 PIIFGGGG 23.9373 0 0 0 0 0 22.7572 0 0 0 24.2585 24.2585 22.8494 21.9863 21.9863 0 0 0 A0A9Q1HE00 A0A9Q1HE00_HOLLE Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein HOLleu_09229 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0264 -23.442 AGHSMGGHGAWH 0 0 0 18.0814 0 0 0 0 0 0 0 0 0 0 0 17.1944 17.7275 17.7275 A0A9Q1HE08 A0A9Q1HE08_HOLLE Hyalin HOLleu_13579 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509] 2 0.9 1.0093 -7.0558 QPGTAFAVG;VQDSTCTQYTCQCPNCFTGRFC 0 0 0 0 0 0 0 0 0 0 0 0 0 17.6733 17.6733 0 0 0 A0A9Q1HE10 A0A9Q1HE10_HOLLE A disintegrin and metalloproteinase with thrombospondin motifs 18 HOLleu_12679 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] 1 1 1.0027 -6.2493 NSEAPCVDEYHWC 0 0 0 0 0 0 0 0 0 29.9468 0 0 0 0 0 0 0 0 A0A9Q1HE13 A0A9Q1HE13_HOLLE VWFC domain-containing protein HOLleu_09289 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.8 0.75 -0.068637 DECNLCVC 0 0 0 0 0 0 0 0 0 23.2091 0 0 0 0 0 0 0 0 A0A9Q1HE25 A0A9Q1HE25_HOLLE Ubiquitin-protein ligase E3B HOLleu_09684 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] ligase activity [GO:0016874]; ubiquitin protein ligase activity [GO:0061630] 1 0.7 1.0159 -23.777 KHLMLKHL 0 0 0 0 0 0 0 0 0 0 0 0 20.0729 0 0 0 0 0 A0A9Q1HE38 A0A9Q1HE38_HOLLE Transmembrane protease serine 11C HOLleu_09391 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) acrosome reaction [GO:0007340]; proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] 2 3.7 1.0109 -7.2067 CDDFDDCGDNWDEQNCGGE;SWQCDDWDD 20.9526 25.4226 25.4226 0 0 0 0 0 0 26.0653 25.6907 25.6907 0 0 0 0 0 0 A0A9Q1HE46 A0A9Q1HE46_HOLLE DUF4550 domain-containing protein HOLleu_04822 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.5 0.85526 -0.068637 GGDTSGNH 0 24.4967 24.4967 0 0 0 0 0 0 0 0 0 20.1358 19.8246 19.8246 0 0 0 A0A9Q1HE84 A0A9Q1HE84_HOLLE "Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase" HOLleu_12863 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]" 1 2.4 0.86486 -0.068637 TMGHPDHF 0 0 0 0 0 0 0 0 0 0 0 0 0 21.1257 21.1257 0 0 0 A0A9Q1HEA1 A0A9Q1HEA1_HOLLE Crt-like 3 HOLleu_05046 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2 1.018 -23.777 GGGGGGEH 22.3313 0 0 0 0 0 0 0 0 0 20.8359 20.8359 0 0 0 0 0 0 A0A9Q1HEC6 A0A9Q1HEC6_HOLLE SRCR domain-containing protein HOLleu_13013 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5.4 1.0113 -5.5027 SVACDMHDSSTNMYDD 0 24.3613 24.3613 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HED4 A0A9Q1HED4_HOLLE Tubulin beta chain HOLleu_13070 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200] 1 3.3 1.0145 -5.7538 YQQYQDATADDEGEF 23.1833 24.297 24.297 0 17.4563 17.4563 0 0 0 28.603 24.2105 24.2105 0 0 0 0 0 0 A0A9Q1HEE3 A0A9Q1HEE3_HOLLE Uncharacterized protein HOLleu_09799 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.6 1.0124 -11.621 PEDSSSDDSDDASTELNQ 0 0 0 0 0 0 0 18.5674 18.5674 0 16.7523 16.7523 0 0 0 0 0 0 A0A9Q1HEE4 A0A9Q1HEE4_HOLLE Uncharacterized protein HOLleu_05238 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) syncytium formation by plasma membrane fusion [GO:0000768] cell-cell contact zone [GO:0044291]; membrane [GO:0016020] 1 2.6 1.0151 -5.7538 VCDCPGGSEHCTEDT 22.1112 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HEG6 A0A9Q1HEG6_HOLLE Cholecystokinin receptor type A HOLleu_10331 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 3.1 0.9691 -0.12993 LPKLRVVPNLL 22.5994 24.4253 24.4253 22.3015 21.7615 21.7615 24.6349 23.423 23.423 24.6963 24.215 24.215 20.1645 20.6423 20.6423 21.9841 21.1164 21.1884 A0A9Q1HEG8 A0A9Q1HEG8_HOLLE Uncharacterized protein HOLleu_13175 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 17.5 1.0129 -11.621 SKDESEDEYEDESEDESE 0 0 0 0 0 0 0 18.6255 18.6255 0 0 0 0 0 0 0 0 0 A0A9Q1HEH7 A0A9Q1HEH7_HOLLE Cytochrome P450 2J2 HOLleu_05400 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) organic acid metabolic process [GO:0006082]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" 3 1.8 0.99751 -48.02 IKPYLIKKRR;IKPYLIKKRRL;PKLIVKLRSKVRAHA 0 20.7202 20.7202 18.2495 19.4791 19.4791 21.1497 20.2613 20.2613 22.5212 21.7278 21.7278 0 18.8801 18.8801 17.1767 0 18.5384 A0A9Q1HEK3 A0A9Q1HEK3_HOLLE SH2B adapter protein 2 HOLleu_10042 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] 1 4.8 1.0206 -5.5496 MEGNWTELCEM 0 0 0 0 0 0 0 0 0 22.8378 22.5997 22.5997 18.4291 18.657 18.657 0 0 0 A0A9Q1HEL1 A0A9Q1HEL1_HOLLE Uncharacterized protein HOLleu_10087 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 9.3 1.0124 -2.6427 TDESHCVLC 0 20.6927 20.6927 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HEL5 A0A9Q1HEL5_HOLLE Transcription elongation factor spt6 HOLleu_10103 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome organization [GO:0034728]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; transcription elongation-coupled chromatin remodeling [GO:0140673] transcription elongation factor complex [GO:0008023] DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; translation elongation factor activity [GO:0003746] 1 0.5 1.0175 -2.6427 YEEDEGEDM 0 0 0 0 0 0 0 0 0 22.9123 0 0 0 0 0 0 0 0 A0A9Q1HEM4 A0A9Q1HEM4_HOLLE Plexin-A4 HOLleu_05568 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] 1 0.4 0.82609 -0.068637 PLKQPKAL 0 22.9401 22.9401 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HEM6 A0A9Q1HEM6_HOLLE Hemicentin-1 HOLleu_13354 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2 1.0112 -5.5027 CTDTCGGGSQTHTRTC 0 24.529 24.529 0 0 0 0 0 0 24.8678 0 0 0 20.7878 20.7878 0 0 0 A0A9Q1HER2 A0A9Q1HER2_HOLLE Neurogenic locus notch-like protein 1 HOLleu_10797 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] 1 0.5 1.0176 -23.777 VSTGVVTT 0 0 0 0 0 0 0 0 0 0 0 0 16.9044 0 0 0 0 0 A0A9Q1HES6 A0A9Q1HES6_HOLLE Uncharacterized protein HOLleu_13526 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.9 1.008 -5.3628 EPSEEEMRHLRKMLVFHLNNEIQ 0 20.4594 20.4594 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HET0 A0A9Q1HET0_HOLLE Fibrillin-1 HOLleu_05858 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 3 4.3 1.0071 -8.2948 CSCDHGFY;DTCTCSDINECEMNNGGCDHT;GCLDINECQEGNGGCQ 25.9661 28.8196 28.8196 0 0 0 23.4459 0 0 0 28.3419 28.3419 23.2828 0 0 0 0 0 A0A9Q1HET2 A0A9Q1HET2_HOLLE Neural-cadherin HOLleu_13543 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] 1 0.5 1.0139 -6.0779 NEETGEITTTTEFD 0 0 0 0 0 0 0 0 0 0 23.0468 23.0468 0 0 0 0 0 0 A0A9Q1HEX7 A0A9Q1HEX7_HOLLE N-lysine methyltransferase KMT5A-A HOLleu_11063 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) methylation [GO:0032259] methyltransferase activity [GO:0008168] 1 0.4 1.0167 -23.777 HGQGHVGD 19.056 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HEY0 A0A9Q1HEY0_HOLLE NTR domain-containing protein HOLleu_06095 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020] 1 3 0.87013 -0.068637 IYQPGYFV 0 22.332 22.332 21.1682 0 0 25.8296 0 0 25.918 26.3429 26.3429 26.3568 25.6585 25.6585 17.6939 0 0 A0A9Q1HEZ3 A0A9Q1HEZ3_HOLLE Cell division cycle protein 123 homolog HOLleu_06163 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] 1 3.4 1.0206 -5.5496 MNCSFSSWYNC 22.173 22.1636 22.1636 0 15.937 0 0 0 0 0 21.7052 21.7052 16.9925 17.2927 17.2927 0 0 0 A0A9Q1HF06 A0A9Q1HF06_HOLLE Acylamino-acid-releasing enzyme (EC 3.4.19.1) HOLleu_06225 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) proteolysis [GO:0006508] cytoplasm [GO:0005737] serine-type endopeptidase activity [GO:0004252] 1 1.1 0.9 -0.068637 ISSDENCC 24.3913 24.4189 24.4189 0 20.9187 20.9187 0 0 0 24.6239 24.2262 24.2262 23.3922 23.2445 23.2445 0 0 0 A0A9Q1HF54 A0A9Q1HF54_HOLLE G-protein coupled receptors family 1 profile domain-containing protein HOLleu_09683 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) melanosome organization [GO:0032438]; regulation of calcium-mediated signaling [GO:0050848] melanosome membrane [GO:0033162]; plasma membrane [GO:0005886] dopamine binding [GO:0035240]; L-DOPA binding [GO:0072544]; L-DOPA receptor activity [GO:0035643]; tyrosine binding [GO:0072545] 1 3.1 1.0269 -23.442 VQIQKKFLRIVV 0 0 0 0 0 0 23.0505 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HF65 A0A9Q1HF65_HOLLE Uncharacterized protein HOLleu_09722 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 4.8 1.0165 -2.6427 DTFFELIKP 0 24.3936 24.3936 0 0 0 0 0 0 0 0 0 20.819 20.5446 20.5446 0 0 0 A0A9Q1HFA5 A0A9Q1HFA5_HOLLE Protein shisa-4 HOLleu_06648 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5.1 1.0158 -22.715 CCDTQSNYFLDGLD 0 0 0 0 0 0 0 20.5405 20.5405 0 0 0 0 0 0 0 0 0 A0A9Q1HFA7 A0A9Q1HFA7_HOLLE Snaclec 6 HOLleu_09878 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) signaling receptor activity [GO:0038023] 1 4.3 1.0093 -6.0779 DCATDETAYAGSCY 0 0 0 0 20.6541 0 0 0 0 25.9151 0 0 0 0 0 0 0 0 A0A9Q1HFB2 A0A9Q1HFB2_HOLLE Ig-like domain-containing protein HOLleu_09896 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.1 1.0174 -23.723 YCEDCCTPD 0 0 0 0 0 0 0 0 0 0 0 0 0 21.8453 21.8453 0 0 0 A0A9Q1HFC6 A0A9Q1HFC6_HOLLE Oligosaccharyltransferase complex subunit HOLleu_11103 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein glycosylation [GO:0006486] oligosaccharyltransferase complex [GO:0008250] 1 8.1 1.0276 -23.442 MAKLNRLLLLMV 0 0 0 0 0 0 0 0 0 22.3742 21.7519 21.7519 0 0 0 0 0 0 A0A9Q1HFC7 A0A9Q1HFC7_HOLLE Collagen alpha-1(XXVI) chain HOLleu_09962 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) collagen trimer [GO:0005581] 1 2 0.88372 -0.068637 PAGPAGPK 21.8125 18.8154 18.8154 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HFD9 A0A9Q1HFD9_HOLLE Galaxin HOLleu_07100 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.8 0.89412 -0.068637 MATGNCEP 19.8907 20.7577 20.7577 0 0 0 0 0 0 0 20.235 20.235 16.8817 17.1327 17.1327 0 0 0 A0A9Q1HFF3 A0A9Q1HFF3_HOLLE DDB1- and CUL4-associated factor 5 HOLleu_07154 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.6 1.0184 -2.6427 YPKAAKVLA 0 0 0 17.8168 0 0 21.0022 21.3302 21.3302 0 0 0 0 20.2196 20.2196 0 0 0 A0A9Q1HFG8 A0A9Q1HFG8_HOLLE Uncharacterized protein HOLleu_11295 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 3 1.0252 -23.675 GYWFNCNFAC 19.9665 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HFI4 A0A9Q1HFI4_HOLLE G/T mismatch-specific thymine DNA glycosylase HOLleu_06981 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "base-excision repair, AP site formation [GO:0006285]" nucleus [GO:0005634] pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; uracil DNA N-glycosylase activity [GO:0004844] 1 1.7 0.91566 -0.068637 PMEYMDMN 0 0 0 0 0 0 0 0 0 20.6244 0 0 0 0 0 0 0 0 A0A9Q1HFK5 A0A9Q1HFK5_HOLLE Uncharacterized protein HOLleu_07362 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 12.9 0.98537 -0.65204 NDNDSDGDGDGDGDGDGDGDGDGD;NNDNDNDNDSDGD 0 18.4911 18.4911 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HFL4 A0A9Q1HFL4_HOLLE Protein ARV HOLleu_07395 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular sterol transport [GO:0032366]; regulation of plasma membrane sterol distribution [GO:0097036]; sphingolipid metabolic process [GO:0006665]; sterol metabolic process [GO:0016125] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] 1 3.3 1.0121 -23.777 SYCDHCNK 0 0 0 0 0 0 0 0 0 0 19.7447 19.7447 0 0 0 0 0 0 A0A9Q1HFQ4 A0A9Q1HFQ4_HOLLE Uncharacterized protein HOLleu_10440 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.9 1.0042 -4.979 KPIGKHKTKI 0 28.3941 28.3941 0 24.9952 24.9952 0 27.755 27.755 0 0 0 0 0 0 0 0 0 A0A9Q1HFR7 A0A9Q1HFR7_HOLLE Uncharacterized protein HOLleu_07644 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 0.7 0.86383 -0.068637 LAMVDYMD 0 0 0 0 0 0 0 0 0 0 21.3844 21.3844 0 0 0 0 0 0 A0A9Q1HFU8 A0A9Q1HFU8_HOLLE Galaxin HOLleu_07101 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 1.8 1.0088 -7.1528 NEWGWRRRCC;VTRTKKKT 22.5759 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HG00 A0A9Q1HG00_HOLLE "Histone H1, gonadal" HOLleu_07291 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; structural constituent of chromatin [GO:0030527] 1 5.3 0.99804 -0.39854 LIKKAIVALK 0 0 0 0 0 0 0 21.7251 21.7251 0 0 0 0 0 0 0 0 0 A0A9Q1HG11 A0A9Q1HG11_HOLLE Tripartite motif-containing protein 2 HOLleu_07331 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] 1 1.3 1.0135 -6.0118 PTTPTAPITPTT 0 0 0 0 0 0 21.1733 0 0 0 0 0 21.0308 0 0 0 0 0 A0A9Q1HG34 A0A9Q1HG34_HOLLE Phospholipid scramblase HOLleu_00873 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] 1 7.4 1.0048 -6.2493 CCSGYYWFAGCCV 0 0 0 0 0 0 0 0 0 20.6324 0 0 0 0 0 0 0 0 A0A9Q1HG60 A0A9Q1HG60_HOLLE RING-type E3 ubiquitin transferase (EC 2.3.2.27) HOLleu_11068 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) ubiquitin-dependent protein catabolic process [GO:0006511] plasma membrane [GO:0005886] ubiquitin protein ligase activity [GO:0061630] 1 1.4 1.0135 -6.0118 DYECSDSSSSQE 25.7566 0 0 0 0 0 0 0 0 0 0 0 0 22.38 22.38 0 0 0 A0A9Q1HG85 A0A9Q1HG85_HOLLE Uncharacterized protein HOLleu_08301 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 17.9 1.0234 -23.675 CCTTTCCYLC 0 20.3823 20.3823 0 0 0 0 0 0 0 0 0 17.8528 0 0 0 0 0 A0A9Q1HGB4 A0A9Q1HGB4_HOLLE Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) HOLleu_07724 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] 1 11.3 1.0045 -2.5328 YYTDESTSDEEGEDCEGEEQLE 0 26.1583 26.1583 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HGC7 A0A9Q1HGC7_HOLLE Estrogen-related receptor gamma HOLleu_07763 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular steroid hormone receptor signaling pathway [GO:0030518] nucleus [GO:0005634] estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; zinc ion binding [GO:0008270] 1 2.3 1.0282 -23.631 NRGLHIVRKMR 0 0 0 0 0 0 0 0 0 0 0 0 19.5755 19.6911 19.6911 0 0 0 A0A9Q1HGC8 A0A9Q1HGC8_HOLLE Aggrecan core protein HOLleu_11293 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] signaling receptor activity [GO:0038023] 1 3.1 1.0174 -2.6427 ECRECSEWN 0 22.3706 22.3706 0 0 0 0 0 0 18.3459 0 0 0 0 0 0 0 0 A0A9Q1HGD0 A0A9Q1HGD0_HOLLE Uncharacterized protein HOLleu_08479 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 26.8 1.0073 -2.5328 NDDDDDYNDNDDDNDNSNDGDK 0 20.8146 20.8146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HGD8 A0A9Q1HGD8_HOLLE Zinc finger C2HC domain-containing protein 1C HOLleu_08514 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0242 -23.723 LKPCQNCGR 0 0 0 0 0 0 18.9062 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HGG0 A0A9Q1HGG0_HOLLE Presenilin (EC 3.4.23.-) HOLleu_07879 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta metabolic process [GO:0050435]; calcium ion transport [GO:0006816]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of apoptotic process [GO:0043066]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485] apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cell surface [GO:0009986]; ciliary rootlet [GO:0035253]; dendritic shaft [GO:0043198]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; lysosomal membrane [GO:0005765]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" 1 2.3 1.0278 -23.631 NEYEDDECAVL 0 0 0 0 0 0 0 18.4145 18.4145 0 0 0 0 0 0 0 0 0 A0A9Q1HGG4 A0A9Q1HGG4_HOLLE Pre-mRNA-processing-splicing factor 8 HOLleu_11432 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) spliceosomal tri-snRNP complex assembly [GO:0000244] catalytic step 2 spliceosome [GO:0071013]; U5 snRNP [GO:0005682] metallopeptidase activity [GO:0008237]; pre-mRNA intronic binding [GO:0097157]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070] 1 0.6 1.0032 -6.2493 DYDSHDVERYCRA 0 25.2159 25.2159 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HGM1 A0A9Q1HGM1_HOLLE Delta-like protein HOLleu_08861 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] 1 1.6 1.0021 -6.2493 CEIVDHCASQPCA 0 0 0 0 0 0 0 21.0281 21.0281 0 0 0 0 0 0 0 0 0 A0A9Q1HGM2 A0A9Q1HGM2_HOLLE Fanconi anemia group J protein HOLleu_11632 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) double-strand break repair involved in meiotic recombination [GO:1990918]; nucleotide-excision repair [GO:0006289] nucleus [GO:0005634] "ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; nucleic acid binding [GO:0003676]" 1 1.2 1.0027 -6.2493 NAHWSDEEGCCFQ 0 0 0 0 0 0 0 0 0 23.9506 0 0 0 0 0 0 0 0 A0A9Q1HGS5 A0A9Q1HGS5_HOLLE Cholesterol 24-hydroxylase HOLleu_07116 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cholesterol catabolic process [GO:0006707] cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506] 1 1.9 0.85417 -0.068637 GMETSSVT 20.0998 21.2768 21.2768 0 0 0 0 0 0 20.2185 19.4319 19.4319 0 0 0 0 0 0 A0A9Q1HGV3 A0A9Q1HGV3_HOLLE "GTP 3',8-cyclase (EC 4.1.99.22)" HOLleu_07235 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] molybdopterin synthase complex [GO:0019008] "4 iron, 4 sulfur cluster binding [GO:0051539]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]" 1 2 0.80645 -0.068637 AVGRKKKQ 0 0 0 0 0 0 0 0 0 0 0 0 21.4086 0 0 0 0 0 A0A9Q1HGX3 A0A9Q1HGX3_HOLLE WAP domain-containing protein HOLleu_09312 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular region [GO:0005576]; membrane [GO:0016020] peptidase inhibitor activity [GO:0030414] 3 2.4 1.0161 -22.795 CFCEEHNC;CFDSPCGFCHTEFYID;CTGHNKCCHEYCGSIC 0 0 0 0 0 0 0 17.2375 17.1747 0 25.2718 25.2718 20.1056 0 0 21.4647 24.0851 24.0851 A0A9Q1HGZ2 A0A9Q1HGZ2_HOLLE Gastrotropin HOLleu_07415 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.8 1.0007 -4.979 VVLRRAIESG 21.5889 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HH02 A0A9Q1HH02_HOLLE Neuromedin-U receptor 2 HOLleu_07448 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] 1 1.8 0.80392 -0.068637 PRGLLLKP 0 0 0 19.7314 20.8476 20.8476 0 0 0 0 0 0 0 0 0 18.9785 0 19.7341 A0A9Q1HH03 A0A9Q1HH03_HOLLE Sushi domain-containing protein HOLleu_04825 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0108 -23.777 GDGEMCEG 0 20.185 20.185 0 0 0 0 0 0 20.1024 0 0 0 0 0 0 0 0 A0A9Q1HH06 A0A9Q1HH06_HOLLE Inter-alpha-trypsin inhibitor heavy chain H3 HOLleu_04842 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) hyaluronan metabolic process [GO:0030212] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] 1 1.6 1.0168 -22.715 QRRLWKGHPAHFDF 0 0 0 0 0 0 0 0 0 0 16.25 16.25 0 0 0 0 0 0 A0A9Q1HH29 A0A9Q1HH29_HOLLE Bifunctional lysine-specific demethylase and histidyl-hydroxylase (EC 1.14.11.-) HOLleu_07560 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleolus [GO:0005730] histone H3K36 demethylase activity [GO:0051864]; histone H3K4 demethylase activity [GO:0032453]; iron ion binding [GO:0005506] 1 1.3 0 -0.068637 KPLLVRRH 28.5987 30.3434 30.3434 25.1296 27.8583 27.8583 28.7696 28.5986 28.5986 30.2815 27.1969 27.1969 27.8113 28.1882 28.1882 26.0877 25.3371 25.3617 A0A9Q1HH55 A0A9Q1HH55_HOLLE Netrin receptor UNC5 HOLleu_08674 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] 1 0.9 0.99929 -4.979 MADCLEQTSD 0 0 0 0 0 0 0 22.1999 22.1999 0 0 0 0 0 0 0 0 0 A0A9Q1HH62 A0A9Q1HH62_HOLLE Protein kinase C (EC 2.7.11.13) HOLleu_05069 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872] 1 1.5 1.0213 -5.5496 REDSDSDEESD 0 21.8184 21.8184 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HH71 A0A9Q1HH71_HOLLE Gamma-aminobutyric acid type B receptor subunit 1 HOLleu_07660 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) gamma-aminobutyric acid signaling pathway [GO:0007214] G protein-coupled receptor heterodimeric complex [GO:0038039] G protein-coupled GABA receptor activity [GO:0004965] 1 0.8 0.83929 -0.068637 SSPPPQTQ 0 0 0 0 0 0 22.928 22.9363 22.9363 0 0 0 20.6634 0 0 0 0 0 A0A9Q1HH96 A0A9Q1HH96_HOLLE Lectin-B HOLleu_02759 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chitin binding [GO:0008061] 2 9.7 1.0066 -6.0804 DYCECNGCVDYR;ECSPDGEYFCCSEYGWCGNGDSYCT 26.3005 26.0941 26.0941 16.7706 17.9233 17.9233 0 0 0 25.1125 24.4085 24.4085 22.1054 20.9059 20.9059 0 0 0 A0A9Q1HHA7 A0A9Q1HHA7_HOLLE General transcription factor 3C polypeptide 1 HOLleu_05263 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription initiation at RNA polymerase III promoter [GO:0006384] nucleus [GO:0005634]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677] 1 0.4 0.99929 -4.979 EEEPEQEEYD 23.8186 23.3484 23.3484 0 15.5335 15.5335 0 0 0 0 0 0 17.7996 17.8083 17.8083 0 0 0 A0A9Q1HHB7 A0A9Q1HHB7_HOLLE "Leucine-rich PPR motif-containing protein, mitochondrial" HOLleu_07899 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of mitochondrial translation [GO:0070129] mitochondrion [GO:0005739]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730] 1 0.8 1.0225 -5.5496 MYASMISMCCN 0 0 0 0 0 0 23.7719 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HHD7 A0A9Q1HHD7_HOLLE BEN domain-containing protein 6 HOLleu_02990 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of neuron differentiation [GO:0045666] nucleus [GO:0005634] DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714] 1 3.4 1.027 -23.723 QVVKRCNTT 0 0 0 0 18.3818 18.3818 0 0 0 20.0327 0 0 0 0 0 0 0 0 A0A9Q1HHE3 A0A9Q1HHE3_HOLLE sphingomyelin phosphodiesterase (EC 3.1.4.12) HOLleu_07913 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) sphingomyelin metabolic process [GO:0006684] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020] sphingomyelin phosphodiesterase activity [GO:0004767] 1 0.9 0.99629 -4.7869 WVDDDPDCQADAFHCARF 0 0 0 0 0 0 23.6456 21.8727 21.8727 0 0 0 0 0 0 0 0 0 A0A9Q1HHF1 A0A9Q1HHF1_HOLLE Fibrillin-3 HOLleu_09033 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix [GO:0031012]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; chitin binding [GO:0008061] 4 2.7 0.99964 -40.553 ACEDIDECTDEDN;ASCVNYEGSYNC;HCACPQGEEYSS;IPVCDEHSSCTNTDGS 21.5251 21.8461 21.8461 0 0 0 0 0 0 22.1298 22.9445 22.9445 0 17.4645 17.4645 0 0 0 A0A9Q1HHG3 A0A9Q1HHG3_HOLLE Endoplasmic reticulum membrane-associated RNA degradation protein HOLleu_09067 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.5 1.0149 -16.819 YDGSWQEEVCFNDHVSR 0 0 0 0 0 0 0 19.5059 19.5059 0 0 0 0 0 0 0 0 0 A0A9Q1HHH7 A0A9Q1HHH7_HOLLE E3 ubiquitin-protein ligase TRIM56 HOLleu_09131 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 2 4.8 1.0008 -4.5526 RKKISKFL;SLQCPICLELLKDPRALSCLHRF 0 0 0 0 0 0 0 0 0 0 0 0 0 24.8055 24.8055 0 0 0 A0A9Q1HHK3 A0A9Q1HHK3_HOLLE Uncharacterized protein HOLleu_08091 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.9 1.0174 -21.924 SKPKPKKADVPLHVA 0 0 0 0 0 0 0 19.9613 19.9613 0 0 0 0 0 0 18.0766 0 18.2036 A0A9Q1HHK7 A0A9Q1HHK7_HOLLE "Dynein heavy chain 6, axonemal" HOLleu_09255 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] 1 0.6 1.0067 -5.3628 LALYQTLMPSFQHLKSVIVYCEA 0 0 0 0 0 0 0 0 0 20.4904 0 0 0 0 0 0 0 0 A0A9Q1HHN6 A0A9Q1HHN6_HOLLE Uncharacterized protein HOLleu_08284 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.4 1.0229 -23.631 VGPSDKIGYSN 0 0 0 0 0 0 0 0 0 18.3436 0 0 0 0 0 0 0 0 A0A9Q1HHP4 A0A9Q1HHP4_HOLLE Uncharacterized protein HOLleu_08223 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5 0.81818 -0.068637 LPKYFRKI 22.7519 23.8334 23.8334 20.7287 21.0042 21.0042 0 0 0 22.9867 23.1259 23.1259 0 20.0359 20.0359 19.1177 0 0 A0A9Q1HHQ9 A0A9Q1HHQ9_HOLLE Solute carrier organic anion transporter family member HOLleu_08261 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252] plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347] 1 1.2 0.87234 -0.068637 TAEDGYSD 0 0 0 0 0 0 0 0 0 21.9318 0 0 0 0 0 0 0 0 A0A9Q1HHS3 A0A9Q1HHS3_HOLLE NTR domain-containing protein HOLleu_06019 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191] 1 4.1 0.88172 -0.068637 PYFDDYTT 22.625 22.9936 22.9936 0 0 0 0 0 0 21.7092 0 0 0 18.4053 18.4053 0 0 0 A0A9Q1HHS8 A0A9Q1HHS8_HOLLE Polynucleotide 5'-hydroxyl-kinase NOL9 HOLleu_06036 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; phosphorylation [GO:0016310]" nucleus [GO:0005634] ATP binding [GO:0005524]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731] 1 1.3 1.0058 -6.2493 VDDDFMYDNEEGT 0 26.5049 26.5049 0 0 0 0 0 0 0 25.4811 25.4811 0 0 0 0 0 0 A0A9Q1HHY4 A0A9Q1HHY4_HOLLE Inactive histone-lysine N-methyltransferase 2E HOLleu_05071 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA-templated transcription [GO:0006355] Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] 1 0.7 1.0048 -6.2493 NIPDNYFCEKCEP 22.876 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HI05 A0A9Q1HI05_HOLLE Uncharacterized protein HOLleu_05148 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.8 1.0021 -4.979 NCNSTCNQPE 21.9271 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HI24 A0A9Q1HI24_HOLLE Orphan steroid hormone receptor 2 HOLleu_06440 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] 1 1.3 1.0125 -23.777 PMLTDTHT 18.4954 19.3949 19.3949 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HI43 A0A9Q1HI43_HOLLE CFA20 domain-containing protein HOLleu_06524 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0007 -4.979 PQDSTDDDEM 21.8257 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HI76 A0A9Q1HI76_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_05403 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154]; phosphorylation [GO:0016310]; regulation of signal transduction [GO:0009966] cytosol [GO:0005829] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein serine/threonine kinase activity [GO:0004674] 2 0.7 1.004 -2.7301 PRLILRLLH;RPSVQLPPK 0 0 0 0 0 0 0 0 0 0 0 0 21.0428 20.8075 20.8075 0 0 0 A0A9Q1HI89 A0A9Q1HI89_HOLLE Gamma-aminobutyric acid type B receptor subunit 2 HOLleu_08896 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) gamma-aminobutyric acid signaling pathway [GO:0007214] G protein-coupled receptor heterodimeric complex [GO:0038039] G protein-coupled GABA receptor activity [GO:0004965] 1 0.8 1.0113 -23.777 CNCSTERW 18.0001 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HIC6 A0A9Q1HIC6_HOLLE F-box/LRR-repeat protein 7 HOLleu_04607 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) SCF ubiquitin ligase complex [GO:0019005] 2 2.6 1.0144 -5.7611 QVRKVKSQLH;STEIDQNTFFTEIPSGIMQNGNN 0 0 0 0 0 0 0 0 0 22.6276 0 0 0 0 0 0 0 0 A0A9Q1HID0 A0A9Q1HID0_HOLLE ERO1-like protein beta HOLleu_09048 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein folding in endoplasmic reticulum [GO:0034975] endoplasmic reticulum membrane [GO:0005789] FAD binding [GO:0071949]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972] 1 2.7 1.0053 -6.2493 DDAQMDFCEPQDE 0 25.5592 25.5592 0 18.9929 0 0 0 0 24.1592 23.9801 23.9801 0 0 0 0 0 0 A0A9Q1HID1 A0A9Q1HID1_HOLLE Uncharacterized protein HOLleu_04626 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 7.3 0.99672 -29.489 RRRRPMSYDMRRRDIRQRVRKYRQ;SGDDGNGSGGHD 0 0 0 17.0829 0 0 0 0 0 0 19.6679 19.6679 0 0 0 0 0 0 A0A9Q1HIF1 A0A9Q1HIF1_HOLLE Protein polybromo-1 HOLleu_06983 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) chromatin remodeling [GO:0006338]; transcription elongation by RNA polymerase II [GO:0006368] RSC-type complex [GO:0016586] chromatin binding [GO:0003682]; DNA binding [GO:0003677] 2 2.3 1.0038 -4.2967 EEDEDEEEEEDEEEEGETMEYEDAD;SDDEEEEEEEDEEEEGEDDD 20.6349 21.1702 21.1702 0 0 0 25.7875 0 0 21.6191 21.0331 21.0331 0 25.3441 25.3441 0 0 0 A0A9Q1HIH5 A0A9Q1HIH5_HOLLE Forkhead box protein N3 HOLleu_09232 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700] 1 1.7 1.0158 -2.6427 IKPEQPHCK 0 0 0 18.6522 19.3037 19.3037 0 20.5053 20.5053 0 21.6838 21.6838 19.761 19.703 19.703 17.811 0 18.3211 A0A9Q1HIJ9 A0A9Q1HIJ9_HOLLE Inter-alpha-trypsin inhibitor heavy chain H3 HOLleu_04844 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) hyaluronan metabolic process [GO:0030212] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] 1 1.3 1.0278 -23.442 IIDDPDTEVRMC 0 0 0 0 0 0 0 0 0 0 23.5831 23.5831 0 0 0 0 0 0 A0A9Q1HIK0 A0A9Q1HIK0_HOLLE Uncharacterized protein HOLleu_05901 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.5 1.0218 -23.723 VDGERQYHA 0 0 0 0 0 0 0 0 0 19.6461 0 0 18.775 19.079 19.079 0 0 0 A0A9Q1HIL1 A0A9Q1HIL1_HOLLE Fibrinogen alpha chain HOLleu_04897 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.5 0.96124 -0.068637 SNSCGSCT 17.5292 22.689 22.689 0 0 0 0 0 0 22.0159 22.2142 22.2142 0 15.6926 15.6926 0 0 0 A0A9Q1HIL2 A0A9Q1HIL2_HOLLE Transporter HOLleu_05964 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; neuron projection [GO:0043005] gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332] 1 1.9 1.016 -6.0118 HCNHEWNSEFCS 0 0 0 0 0 0 0 0 0 0 22.5281 22.5281 0 0 0 0 0 0 A0A9Q1HIL8 A0A9Q1HIL8_HOLLE Sorting nexin HOLleu_00276 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; mitotic cell cycle [GO:0000278]; plasma membrane tubulation [GO:0097320]; protein transport [GO:0015031] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] 1 4.1 1.0094 -5.3628 YFLREQIKFYEAITEKLRIALSR 0 0 0 0 0 0 18.7721 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HIL9 A0A9Q1HIL9_HOLLE Nephronectin HOLleu_04823 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion binding [GO:0005509] 1 1.4 1.0118 -5.5027 NNCVHGTCVGPDMCKC 20.656 22.6798 22.6798 0 0 0 0 0 0 20.7955 20.5211 20.5211 0 0 0 0 0 0 A0A9Q1HIM4 A0A9Q1HIM4_HOLLE Uncharacterized protein HOLleu_04841 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 3.5 1.0244 -23.675 LILRAPLLFC 18.9708 21.0874 21.0874 0 0 0 0 0 0 0 0 0 17.6322 18.5542 18.5542 0 0 0 A0A9Q1HIM8 A0A9Q1HIM8_HOLLE Plexin-A4 HOLleu_04858 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) motor neuron axon guidance [GO:0008045]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sensory neuron axon guidance [GO:0097374] plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] 1 0.6 1.0223 -5.5496 NCSQYETCEEC 0 0 0 0 0 0 0 22.5092 22.5092 0 0 0 0 0 0 17.2018 0 17.5014 A0A9Q1HIP3 A0A9Q1HIP3_HOLLE Uncharacterized protein HOLleu_04909 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] 1 3.8 0.99705 -4.7869 SNCSCCRGSNSGSSRGSG 0 23.5805 23.5805 0 0 0 0 0 0 21.0667 20.8751 20.8751 0 0 0 0 0 0 A0A9Q1HIR2 A0A9Q1HIR2_HOLLE "Inositol 1,4,5-trisphosphate receptor" HOLleu_04993 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) release of sequestered calcium ion into cytosol [GO:0051209] endoplasmic reticulum membrane [GO:0005789] "inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220]" 1 0.3 0.98374 -0.068637 YKKICQIL 0 20.9834 20.9834 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HIV8 A0A9Q1HIV8_HOLLE Synaptotagmin-7 HOLleu_05184 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.2 1.0175 -2.6427 MGSSSSSTA 0 0 0 0 0 0 0 0 0 22.8618 0 0 0 0 0 0 0 0 A0A9Q1HIW4 A0A9Q1HIW4_HOLLE HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HOLleu_05202 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) base-excision repair [GO:0006284]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein polyubiquitination [GO:0000209] Golgi membrane [GO:0000139]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 2 0.6 1.0062 -6.7378 EDDDDSDMEEAEEYDITED;SSRSGTTA 0 0 0 0 0 0 0 0 0 0 22.3968 22.3968 0 0 0 0 0 0 A0A9Q1HIW6 A0A9Q1HIW6_HOLLE Uncharacterized protein HOLleu_05363 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 8.2 1.0191 -17.224 LMAEYFQDQYEMYDYD 0 19.1046 19.1046 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HIY1 A0A9Q1HIY1_HOLLE A disintegrin and metalloproteinase with thrombospondin motifs 9 HOLleu_05427 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] 1 0.7 1.0172 -6.0118 YSDWTTCSRPCN 19.7368 22.5281 22.5281 0 0 0 21.3023 0 0 19.2141 17.983 18.5503 0 0 0 0 0 0 A0A9Q1HJ34 A0A9Q1HJ34_HOLLE "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit)" HOLleu_05533 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) mitochondrial respiratory chain complex I [GO:0005747] 1 15.2 0 -0.068637 GPVYYHYLPDPKNRKWSHQEAHRVL 0 21.9248 21.9248 0 0 0 18.8942 18.9869 18.9869 0 0 0 0 0 0 0 0 0 A0A9Q1HJ43 A0A9Q1HJ43_HOLLE Crystal protein HOLleu_06687 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.1 1.0248 -23.675 WTDEYYMCQG 0 18.6856 18.6856 0 0 0 0 0 0 17.8772 17.0387 17.0387 0 0 0 0 0 0 A0A9Q1HJ53 A0A9Q1HJ53_HOLLE TBC1 domain family member 30 HOLleu_06721 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) endoplasmic reticulum [GO:0005783] 1 1.2 1.0233 -23.631 KRRNRTHINVK 0 0 0 0 0 0 0 0 0 0 0 0 19.8397 0 0 0 0 0 A0A9Q1HJ64 A0A9Q1HJ64_HOLLE Venom prothrombin activator pseutarin-C non-catalytic subunit HOLleu_06758 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023] 3 1.7 1.0106 -16.282 DANNTVYCDTF;NGNLDDCPCG;SDDHGDNWYSINNDY 0 23.2121 23.2121 0 0 0 22.3375 22.0274 22.0274 0 0 0 0 0 0 0 0 0 A0A9Q1HJ72 A0A9Q1HJ72_HOLLE Uncharacterized protein HOLleu_05843 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 15.3 1.0255 -5.5496 EPTEDHEEDYM 22.0655 21.766 21.766 0 0 0 0 0 0 0 0 0 18.2553 18.3005 18.3005 0 0 0 A0A9Q1HJ74 A0A9Q1HJ74_HOLLE Uncharacterized protein HOLleu_05719 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 0.99259 -0.068637 MPKWIIVG 23.1959 0 0 0 20.8853 20.8853 0 0 0 0 22.2348 22.2348 0 0 0 20.6105 0 20.5996 A0A9Q1HJ78 A0A9Q1HJ78_HOLLE Recombining binding protein suppressor of hairless HOLleu_01403 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" 1 1.5 1.0165 -2.6427 GAGAHGDGG 19.2916 21.3817 21.3817 0 0 0 0 0 0 21.4523 21.1469 21.1469 19.1521 18.0706 18.0706 0 0 0 A0A9Q1HJ89 A0A9Q1HJ89_HOLLE High mobility group protein HMGI-C HOLleu_05795 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) positive regulation of macromolecule metabolic process [GO:0010604]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleus [GO:0005634] DNA binding [GO:0003677]; transcription coregulator activity [GO:0003712] 1 4 1.0272 -0.068637 RPRGRPKG 19.4351 20.574 20.574 14.9319 0 0 0 0 0 20.8135 20.002 20.002 16.3787 16.7681 16.7681 0 0 0 A0A9Q1HJA4 A0A9Q1HJA4_HOLLE E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) HOLleu_05878 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631] 1 6.1 1.0263 -5.5496 SQEEQSSDSES 0 22.5304 22.5304 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HJF8 A0A9Q1HJF8_HOLLE B box-type domain-containing protein HOLleu_01827 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] 1 2.5 1.0256 -23.631 CGKHNDIECRF 20.1608 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HJK1 A0A9Q1HJK1_HOLLE Transcription elongation factor SPT5 HOLleu_00278 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation-coupled chromatin remodeling [GO:0140673] DSIF complex [GO:0032044] mRNA binding [GO:0003729]; translation elongation factor activity [GO:0003746] 1 0.9 1.0231 -23.675 IGSPAVDEDD 0 18.5346 18.5346 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HJK2 A0A9Q1HJK2_HOLLE Sulfotransferase HOLleu_06442 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] sulfotransferase activity [GO:0008146] 2 5.7 0.99921 -3.3573 IPKIKTKVLRIGSKL;NEGMCQGHY 0 0 0 0 0 0 0 0 0 24.5795 0 0 0 0 0 0 0 0 A0A9Q1HJM2 A0A9Q1HJM2_HOLLE Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein HOLleu_06421 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 2 2.4 1.0111 -2.2424 LFYKISKV;VFSFLLIV 20.4303 22.5052 22.5052 0 17.4218 17.4218 0 0 0 0 0 0 17.4098 17.5507 17.5507 15.273 0 0 A0A9Q1HJP8 A0A9Q1HJP8_HOLLE Uncharacterized protein HOLleu_06543 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.3 1.0231 -23.723 YTSDEDCEM 0 0 0 0 0 0 0 0 0 0 0 0 17.3071 0 0 0 0 0 A0A9Q1HJQ2 A0A9Q1HJQ2_HOLLE Transient receptor potential cation channel subfamily V member 6 HOLleu_06653 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) calcium ion import across plasma membrane [GO:0098703] plasma membrane [GO:0005886] calcium channel activity [GO:0005262] 1 1 1.0069 -0.068637 LGGRGFLI 0 0 0 0 0 0 0 0 0 21.297 0 0 0 0 0 0 0 0 A0A9Q1HJS1 A0A9Q1HJS1_HOLLE Uncharacterized protein HOLleu_00577 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7 1.0182 -2.6427 LEECDGYCY 20.3382 21.2326 21.2326 0 0 0 0 0 0 20.5053 19.6956 19.6956 17.6198 17.2797 17.2797 0 0 0 A0A9Q1HJS3 A0A9Q1HJS3_HOLLE Calcium-activated chloride channel regulator 1 HOLleu_06743 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.1 1.0027 -4.979 LLQPKDLFSV 0 21.0895 21.0895 0 0 0 0 0 0 0 21.867 21.867 0 0 0 0 0 0 A0A9Q1HJS4 A0A9Q1HJS4_HOLLE non-specific serine/threonine protein kinase (EC 2.7.11.1) HOLleu_06649 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; regulation of mRNA processing [GO:0050684]; spliceosomal complex assembly [GO:0000245] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] 1 0.8 1.0113 -23.777 EHAMNNVN 0 0 0 0 0 0 0 0 0 0 0 0 19.8233 0 0 0 0 0 A0A9Q1HJV8 A0A9Q1HJV8_HOLLE Neuronal acetylcholine receptor subunit alpha-9 HOLleu_06776 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020]; neuron projection [GO:0043005]; synapse [GO:0045202] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] 1 2.5 1.0065 -6.2493 TDGNEQDGEHSEG 0 0 0 0 0 0 0 0 0 0 0 0 22.4847 0 0 0 0 0 A0A9Q1HJX6 A0A9Q1HJX6_HOLLE RNA-directed DNA polymerase from mobile element jockey HOLleu_06861 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell adhesion involved in heart morphogenesis [GO:0061343]; larval heart development [GO:0007508] extracellular matrix [GO:0031012] RNA-directed DNA polymerase activity [GO:0003964] 2 1.6 0.97479 -0.13727 DSGISDHD;FYQMGNHT 21.9198 23.4593 23.4593 0 0 0 0 0 0 20.8378 22.9194 22.9194 0 0 0 0 0 0 A0A9Q1HJY6 A0A9Q1HJY6_HOLLE Methyltransferase type 11 domain-containing protein HOLleu_02784 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.1 1.0147 -6.0118 DFAMGTGVMGEM 19.8256 21.1741 21.1741 0 0 0 0 0 0 0 19.7335 19.7335 0 0 0 0 0 0 A0A9Q1HJZ6 A0A9Q1HJZ6_HOLLE "NACHT, LRR and PYD domains-containing protein 10" HOLleu_00933 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0147 -6.0118 CDSYIMTNEEYE 0 0 0 0 0 0 21.3509 22.7393 22.7393 18.3103 17.7053 17.7053 0 0 0 0 0 0 A0A9Q1HK39 A0A9Q1HK39_HOLLE "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase" HOLleu_00106 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]" 1 17.3 1.017 -23.027 HTDAHDFEEEHTL 0 0 0 0 0 0 22.0782 22.0247 22.0247 0 0 0 0 0 0 0 0 0 A0A9Q1HK91 A0A9Q1HK91_HOLLE Uncharacterized protein HOLleu_01423 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.7 1.0244 -23.723 LFVKLFIRL 0 0 0 0 0 0 0 0 0 0 0 0 0 22.2886 22.2886 0 0 0 A0A9Q1HKD7 A0A9Q1HKD7_HOLLE Uncharacterized protein HOLleu_00517 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 5.2 1.0117 -23.777 DPFFWMCC 0 0 0 0 0 0 0 0 0 18.7855 0 0 0 0 0 0 0 0 A0A9Q1HKI2 A0A9Q1HKI2_HOLLE Uncharacterized protein HOLleu_00729 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 7.9 1 -0.31124 LPDQKHISKRTLKKTRVLEKPINL 0 0 0 0 0 0 0 0 0 0 21.8852 21.8852 0 0 0 0 0 0 A0A9Q1HKJ0 A0A9Q1HKJ0_HOLLE MAM and LDL-receptor class A domain-containing protein 1 HOLleu_03960 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 8 1.6 1.0037 -24.913 CLEFYYHMFGDDS;CTNGFCIPQSMECDFSDDCGDR;DDEVCPYYTRCNFEDGMCE;DDPDDDFD;FPDCPTQSDEEECGYACQ;WRCGDGGC;YMYVDQSQ;YYHMFGDTINT 0 22.7451 22.7451 17.1878 17.7235 17.7235 0 0 0 24.7757 21.4687 21.4687 0 0 0 0 0 0 A0A9Q1HKM1 A0A9Q1HKM1_HOLLE "NACHT, LRR and PYD domains-containing protein 1a" HOLleu_00912 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.1 1.0198 -21.924 NTFCEWYAACYLSRN 0 0 0 0 0 0 0 19.64 19.64 0 0 0 0 0 0 0 0 0 A0A9Q1HKN5 A0A9Q1HKN5_HOLLE Carboxypeptidase N subunit 2 HOLleu_00970 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cell differentiation [GO:0030154] plasma membrane [GO:0005886] carboxypeptidase activity [GO:0004180] 2 1.8 0.99374 -0.35444 ILHGNQIAHLSA;PDACGAHG 20.6547 21.5 21.5 0 16.1426 16.1426 0 0 0 20.7847 20.2885 20.2885 0 0 0 0 0 0 A0A9Q1HKQ4 A0A9Q1HKQ4_HOLLE WD repeat-containing protein 76 HOLleu_02194 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of DNA damage checkpoint [GO:2000001] nucleus [GO:0005634] DNA binding [GO:0003677] 1 2.5 1.0193 -21.924 FYVTEPLEDRQRERH 0 19.3057 19.3057 0 16.5491 16.5491 18.0465 17.491 17.491 0 0 0 0 0 0 0 0 0 A0A9Q1HKR1 A0A9Q1HKR1_HOLLE Uncharacterized protein HOLleu_01098 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 5.6 1.0104 -6.0118 EDEDGDNENETG 20.5087 22.3236 22.3236 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HKR3 A0A9Q1HKR3_HOLLE Insulin-like growth factor-binding protein complex acid labile subunit HOLleu_02232 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 0.8 1.0105 -2.6427 AWMDFFCES 0 0 0 0 0 0 21.6113 21.1637 21.1637 22.6242 22.144 22.144 0 0 0 0 0 0 A0A9Q1HKR4 A0A9Q1HKR4_HOLLE Immunoglobulin subtype domain-containing protein HOLleu_01280 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 1.6 1.0248 -23.631 MDDFGEEEYSF 0 0 0 0 0 0 0 0 0 18.8803 18.4103 18.4103 0 0 0 0 0 0 A0A9Q1HKR6 A0A9Q1HKR6_HOLLE C2H2-type domain-containing protein HOLleu_01125 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1.5 1.0265 -23.027 SSDDKDSVSEDKC 0 0 0 0 0 0 0 0 0 0 0 0 21.3025 0 0 0 0 0 A0A9Q1HKT7 A0A9Q1HKT7_HOLLE protein adenylyltransferase (EC 2.7.7.108) HOLleu_01385 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] AMPylase activity [GO:0070733]; ATP binding [GO:0005524] 1 4.3 1.0109 -11.395 RVFERARQEFYYLQVYHTT 0 0 0 0 0 0 0 0 0 0 19.9686 19.9686 0 0 0 0 0 0 A0A9Q1HKV4 A0A9Q1HKV4_HOLLE Zinc finger CCHC domain-containing protein 3 HOLleu_01464 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) activation of innate immune response [GO:0002218] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] 1 1.4 0.8835 -0.068637 GGVPGGDG 0 0 0 20.3513 20.7024 20.7024 0 0 0 21.5548 0 0 22.3608 0 0 18.5828 0 0 A0A9Q1HKW5 A0A9Q1HKW5_HOLLE Reverse transcriptase domain-containing protein HOLleu_04569 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 2.6 1.0144 -5.5027 YVISCDSCGCHYTGCT 0 0 0 0 0 0 0 0 0 21.3518 0 0 0 0 0 0 0 0 A0A9Q1HL21 A0A9Q1HL21_HOLLE SMB domain-containing protein HOLleu_02765 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) membrane [GO:0016020] 1 2.5 1.0166 -2.6427 SRCSCHPAC 0 0 0 0 0 0 21.0793 20.9295 20.9295 0 0 0 16.5017 0 0 0 0 0 A0A9Q1HL27 A0A9Q1HL27_HOLLE Prolow-density lipoprotein receptor-related protein 1 HOLleu_02804 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) plasma membrane [GO:0005886] 1 20.2 0.99776 -4.564 GDNDCVNGSDEADCGTQLW 0 0 0 0 0 0 0 0 0 23.332 0 0 0 0 0 0 0 0 A0A9Q1HL39 A0A9Q1HL39_HOLLE NACHT domain-containing protein HOLleu_01973 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 2 3.2 1.0093 -7.1528 KDVKILIFLR;VVKTLKGG 0 0 0 0 22.0706 22.0706 23.1872 22.7677 22.7677 0 25.0249 25.0249 0 0 0 0 0 0 A0A9Q1HL80 A0A9Q1HL80_HOLLE Tripartite motif-containing protein 59 HOLleu_02057 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] 1 4.5 1.0015 -4.564 NDEEEIHDNSDEETDDDDE 0 23.0545 23.0545 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HLH0 A0A9Q1HLH0_HOLLE Uncharacterized protein HOLleu_02668 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 3 12.9 1.0042 -23.777 SDSDSGHK;SSSSSSSSD;SSSSSSSSSSSSSSD 0 0 0 0 0 0 0 0 0 0 0 0 0 18.641 18.641 0 0 0 A0A9Q1HLI6 A0A9Q1HLI6_HOLLE Uncharacterized protein HOLleu_02641 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) nucleus [GO:0005634] histone binding [GO:0042393] 1 1.1 0.87368 -0.068637 TNCGGDAD 22.1191 23.1535 23.1535 0 15.8116 0 0 0 0 21.8674 24.8948 24.8948 23.3723 19.0855 19.0855 0 0 0 A0A9Q1HLX0 A0A9Q1HLX0_HOLLE Uncharacterized protein HOLleu_03461 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 4.4 1.012 -2.5328 YESFQDGSFDEEEEDDDEDLNS 24.186 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A9Q1HM02 A0A9Q1HM02_HOLLE ATP-dependent DNA helicase HOLleu_03796 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 1 1.0115 -6.0118 QGDMSCQAQDNN 0 0 0 0 0 0 0 0 0 22.8339 0 0 0 0 0 0 0 0 A0A9Q1HM34 A0A9Q1HM34_HOLLE Tyrosine-protein kinase receptor Tie-1 HOLleu_04004 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] kinase activity [GO:0016301] 2 3.2 1.0108 -7.4296 CDAFCTCNAGYQGEFCEQ;ECQFDCHCD 21.5445 0 0 0 0 0 0 0 0 24.1451 0 0 0 0 0 0 0 0 A0A9Q1HM53 A0A9Q1HM53_HOLLE Leucine-rich repeat-containing G-protein coupled receptor 6 HOLleu_04104 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) 1 6.7 0.99929 -4.979 MNNEMTNLSE 0 0 0 0 0 0 21.2216 0 0 0 0 0 20.0505 19.8532 19.8532 0 0 0 A0A9Q1HMC3 A0A9Q1HMC3_HOLLE Protein NLRC5 HOLleu_04510 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) regulation of apoptotic process [GO:0042981] 1 0.5 1.0021 -4.979 PLKLVKHQTI 0 0 0 17.9625 0 0 0 20.2926 20.2926 22.4252 0 0 0 0 0 0 0 18.4637 A0A9Q1HME6 A0A9Q1HME6_HOLLE Serine/threonine-protein kinase VRK1 HOLleu_04504 Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria leucospilota) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] 1 0.5 1.0239 -23.675 YDDGGGGGGC 0 18.7614 18.7614 0 0 0 0 0 0 18.7753 18.4903 18.4903 0 0 0 0 0 0